Read in Data

read_csv("../output/rev_coral_join.csv") -> rev_coral_join
## Rows: 778 Columns: 5897
## ── Column specification ────────────────────────────────────────────────────────
## Delimiter: ","
## chr    (6): Clade, Majority, sample_id, species, region, reef
## dbl (5891): ITS2_type, its2_count, ASV0001, ASV0002, ASV0003, ASV0004, ASV00...
## 
## ℹ Use `spec()` to retrieve the full column specification for this data.
## ℹ Specify the column types or set `show_col_types = FALSE` to quiet this message.

Clade C and Non-Clade C Label Subsetting

# Assuming 'df' is your data frame with a column 'labels' and you want to balance the labels

# Extract the minority class samples (139 observations)
minority_class <- rev_coral_join[rev_coral_join$Clade == 'C', ]

# Extract the majority class samples (the rest of the dataset)
majority_class <- rev_coral_join[rev_coral_join$Clade != 'C', ]

# Randomly sample from the majority class to match the size of the minority class
set.seed(42)  # Set a seed for reproducibility
balanced_majority <- majority_class[sample(nrow(majority_class), nrow(minority_class)), ]

# Combine the balanced datasets
balanced_df <- rbind(balanced_majority, minority_class)

# Shuffle the rows to randomize the order
balanced_df <- balanced_df[sample(nrow(balanced_df)), ]
dim(balanced_df)
## [1]  278 5897
unique(balanced_df$Clade)
## [1] "C" "A" "G" "D"
length(balanced_df$Clade=="C")
## [1] 278
length(balanced_df$Clade != "C")
## [1] 278

Read in results from PCA Clade C Dim 1 Results

read_csv("../output/clade_c_pca_Ranks.csv") -> clade_c_pca_Ranks
## Rows: 3226 Columns: 1
## ── Column specification ────────────────────────────────────────────────────────
## Delimiter: ","
## chr (1): ASV
## 
## ℹ Use `spec()` to retrieve the full column specification for this data.
## ℹ Specify the column types or set `show_col_types = FALSE` to quiet this message.
# subset ASV columns for Logistic Regression based on clade C PCA results in Dimension 1
balanced_df %>% 
  select(sample_id, Clade, (clade_c_pca_Ranks$ASV)) -> lr_data
#glimpse(lr_data)
head(lr_data)
## # A tibble: 6 × 3,228
##   sample_id  Clade ASV1236 ASV0421 ASV0691 ASV0899 ASV1004 ASV1041 ASV1058
##   <chr>      <chr>   <dbl>   <dbl>   <dbl>   <dbl>   <dbl>   <dbl>   <dbl>
## 1 SKAU-R2-23 C           0       0       0       0       0       0       0
## 2 SWAJ-R4-3  A           0       0       0       0       0       0       0
## 3 SYAN-R3-19 C           0       0       0       0       0       0       0
## 4 PMAQ-R2-19 A           0       0       0       0       0       0       0
## 5 SDOG-R3-6  A           0       0       0       0       0       0       0
## 6 PDOG-R2-22 A         234     147      90     103      60      42      49
## # ℹ 3,219 more variables: ASV12542 <dbl>, ASV1294 <dbl>, ASV13113 <dbl>,
## #   ASV1318 <dbl>, ASV2269 <dbl>, ASV2542 <dbl>, ASV2660 <dbl>, ASV2737 <dbl>,
## #   ASV2840 <dbl>, ASV3053 <dbl>, ASV3077 <dbl>, ASV3134 <dbl>, ASV3140 <dbl>,
## #   ASV3579 <dbl>, ASV6119 <dbl>, ASV7557 <dbl>, ASV8422 <dbl>, ASV1086 <dbl>,
## #   ASV1310 <dbl>, ASV15750 <dbl>, ASV16905 <dbl>, ASV2033 <dbl>,
## #   ASV2089 <dbl>, ASV2127 <dbl>, ASV2725 <dbl>, ASV2804 <dbl>, ASV3075 <dbl>,
## #   ASV3327 <dbl>, ASV3342 <dbl>, ASV3532 <dbl>, ASV3600 <dbl>, …
lr_data %>% 
  mutate(Clade = case_when(Clade=="C" ~ 1, 
                           .default = 0)) -> lr_data

Double-check if any columns sum to 0

# take out sample and clade columns for numeric only
map(lr_data[,-c(1,2)], ~sum(.)) %>% 
  as.data.frame() %>% 
  pivot_longer(cols = everything()) %>% 
  filter(value==0)
## # A tibble: 0 × 2
## # ℹ 2 variables: name <chr>, value <dbl>
dim(lr_data)
## [1]  278 3228

  • No columns sum to 0. This had been taken care of when subsetting for Clade C to have ASVs sequenced in Clade C.

  • There is sequencing data for Clade C and non-Clade C observations that are all non-zero when summing each ASV column.

dim(lr_data)
## [1]  278 3228
  • 1,331 ASV columns
  • 1 sample ID column
  • 1 target label column of Clade

Correlation Matrix on CLR

cor(lr_clr_df[,-c(1,2)]) -> cor_lr_clr

Insert fancy corr plot here - whether on CLR or counts based

t-SNE plot of Clade C and non-Clade C

library(tsne)
library(plotly)
## 
## Attaching package: 'plotly'
## The following object is masked from 'package:ggplot2':
## 
##     last_plot
## The following object is masked from 'package:stats':
## 
##     filter
## The following object is masked from 'package:graphics':
## 
##     layout
data(lr_clr_df)
## Warning in data(lr_clr_df): data set 'lr_clr_df' not found
features <- subset(lr_clr_df, select = -c(1,2)) 

set.seed(0)
tsne <- tsne(features, initial_dims = 2)
## sigma summary: Min. : 0.0678215778208645 |1st Qu. : 0.0916334485210355 |Median : 0.106756334806171 |Mean : 0.145508390913786 |3rd Qu. : 0.136747935696713 |Max. : 1.33140136971437 |
## Epoch: Iteration #100 error is: 11.9931544984992
## Epoch: Iteration #200 error is: 0.176468277811214
## Epoch: Iteration #300 error is: 0.167732330784209
## Epoch: Iteration #400 error is: 0.165431266607314
## Epoch: Iteration #500 error is: 0.16515252252442
## Epoch: Iteration #600 error is: 0.165050262676511
## Epoch: Iteration #700 error is: 0.165008046466993
## Epoch: Iteration #800 error is: 0.164989381654186
## Epoch: Iteration #900 error is: 0.164981014702747
## Epoch: Iteration #1000 error is: 0.164977194945977
tsne <- data.frame(tsne)
pdb <- cbind(tsne,lr_clr_df$Clade)
options(warn = -1)
fig2 <-  plot_ly(data = pdb ,x =  ~X1, y = ~X2, type = 'scatter', mode = 'markers', split = ~lr_clr_df$Clade)

fig2 <- fig2 %>%
  layout(
    plot_bgcolor = "#e5ecf6"
  )

fig2

GGally::ggpairs for Clade C

# quick subset for visualization
subset_lr <- lr_clr_df[,-1] %>% 
  select(1:10)

GGally::ggpairs(subset_lr, aes(color = as.factor(Clade))) -> ggpairs_10_clade_c
## Registered S3 method overwritten by 'GGally':
##   method from   
##   +.gg   ggplot2
ggpairs_10_clade_c

ggsave("../plots/ggpairs_10_clade_c.png", width = 14, height = 12, plot = ggpairs_10_clade_c)

Separate Training and Testing for later after experimenting with whole dataset first

set.seed(1234)
Z <- sample(nrow(lr_clr_df), .85*nrow(lr_clr_df))
lr_train <- lr_clr_df[Z,]
lr_test <- lr_clr_df[-Z,]

# take a peek at training data
head(lr_train, 20)
## # A tibble: 20 × 3,228
##    sample_id  Clade ASV1236 ASV0421 ASV0691 ASV0899 ASV1004 ASV1041 ASV1058
##    <chr>      <dbl>   <dbl>   <dbl>   <dbl>   <dbl>   <dbl>   <dbl>   <dbl>
##  1 PWAJ-R3-8      0 -0.0759  -0.167  -0.135 -0.0486   0.122 -0.0382   0.130
##  2 SYAN-R1-11     1 -0.0759  -0.167  -0.135 -0.0486   0.122 -0.0382   0.130
##  3 SMAQ-R1-5      1 -0.0759  -0.167  -0.135 -0.0486   0.122 -0.0382   0.130
##  4 PWAJ-R3-1      0 -0.0759  -0.167  -0.135 -0.0486   0.122 -0.0382   0.130
##  5 SYAN-R1-16     1 -0.0759  -0.167  -0.135 -0.0486   0.122 -0.0382   0.130
##  6 PMAQ-R2-29     1 -0.0759  -0.167  -0.135 -0.0486   0.122 -0.0382   0.130
##  7 PMAQ-R1-4      1 -0.0759  -0.167  -0.135 -0.0486   0.122 -0.0382   0.130
##  8 PKAU-R3-3      0 -0.0759  -0.167  -0.135 -0.0486   0.122 -0.0382   0.130
##  9 SYAN-R4-3      0 -0.0759  -0.167  -0.135 -0.0486   0.122 -0.0382   0.130
## 10 PKAU-R1-17     0 -0.0759  -0.167  -0.135 -0.0486   0.122 -0.0382   0.130
## 11 SWAJ-R3-23     0 -0.0759  -0.167  -0.135 -0.0486   0.122 -0.0382   0.130
## 12 PMAQ-R2-19     0 -0.0759  -0.167  -0.135 -0.0486   0.122 -0.0382   0.130
## 13 SYAN-R1-12     1 -0.0759  -0.167  -0.135 -0.0486   0.122 -0.0382   0.130
## 14 PDOG-R1-29     0 -0.0759   5.72   -0.135 -7.66     0.122  8.87     0.130
## 15 PMAQ-R2-18     1 -0.0759  -0.167  -0.135 -0.0486   0.122 -0.0382   0.130
## 16 SFAR-R2-25     0 -0.0759  -0.167   4.11  -0.0486   0.122 -0.0382  -1.83 
## 17 SKAU-R2-31     0 -0.0759  -0.167  -0.135 -0.0486   0.122 -0.0382   0.130
## 18 SWAJ-R3-10     0 -0.0759  -0.167  -0.135 -0.0486   0.122 -0.0382   0.130
## 19 SYAN-R1-20     1 -0.0759  -0.167  -0.135 -0.0486   0.122 -0.0382   0.130
## 20 PMAQ-R2-7      0 -0.0759  -0.167  -0.135 -0.0486   0.122 -0.0382   0.130
## # ℹ 3,219 more variables: ASV12542 <dbl>, ASV1294 <dbl>, ASV13113 <dbl>,
## #   ASV1318 <dbl>, ASV2269 <dbl>, ASV2542 <dbl>, ASV2660 <dbl>, ASV2737 <dbl>,
## #   ASV2840 <dbl>, ASV3053 <dbl>, ASV3077 <dbl>, ASV3134 <dbl>, ASV3140 <dbl>,
## #   ASV3579 <dbl>, ASV6119 <dbl>, ASV7557 <dbl>, ASV8422 <dbl>, ASV1086 <dbl>,
## #   ASV1310 <dbl>, ASV15750 <dbl>, ASV16905 <dbl>, ASV2033 <dbl>,
## #   ASV2089 <dbl>, ASV2127 <dbl>, ASV2725 <dbl>, ASV2804 <dbl>, ASV3075 <dbl>,
## #   ASV3327 <dbl>, ASV3342 <dbl>, ASV3532 <dbl>, ASV3600 <dbl>, …
dim(lr_train)
## [1]  236 3228
dim(lr_test)
## [1]   42 3228

check label distribution of CLade C = 1 and Non-Clade-C = 0

ggplot(lr_clr_df, aes( x = Clade)) +
  geom_histogram(stat = 'count') +
  ggtitle("Label Distributions of Clade C = 1 vs. Non-Clade C = 0") +
  theme_bw()

Experiment with whole dataset based on CLR Transformation

glmnet::glmnet

3226

y = as.factor(lr_clr_df$Clade)
x = as.matrix(lr_clr_df[,-c(1,2)])

any(is.na(x))
## [1] FALSE
library(glmnet)
## Loading required package: Matrix
## 
## Attaching package: 'Matrix'
## The following objects are masked from 'package:tidyr':
## 
##     expand, pack, unpack
## Loaded glmnet 4.1-8
## 
## Attaching package: 'glmnet'
## The following object is masked from 'package:compositions':
## 
##     rmult
lr_model <- glmnet(x, y, 
                 family = "binomial", 
                 #alpha = 1 # lasso L1 norm
                 alpha = 0 # ridge L2 norm
                )
plot(lr_model)

summary(lr_model)
##            Length Class     Mode     
## a0            100 -none-    numeric  
## beta       322600 dgCMatrix S4       
## df            100 -none-    numeric  
## dim             2 -none-    numeric  
## lambda        100 -none-    numeric  
## dev.ratio     100 -none-    numeric  
## nulldev         1 -none-    numeric  
## npasses         1 -none-    numeric  
## jerr            1 -none-    numeric  
## offset          1 -none-    logical  
## classnames      2 -none-    character
## call            5 -none-    call     
## nobs            1 -none-    numeric
lr_model
## 
## Call:  glmnet(x = x, y = y, family = "binomial", alpha = 0) 
## 
##       Df  %Dev  Lambda
## 1   3226  0.00 161.800
## 2   3226  3.00 154.400
## 3   3226  3.13 147.400
## 4   3226  3.27 140.700
## 5   3226  3.42 134.300
## 6   3226  3.57 128.200
## 7   3226  3.73 122.400
## 8   3226  3.89 116.800
## 9   3226  4.06 111.500
## 10  3226  4.24 106.500
## 11  3226  4.42 101.600
## 12  3226  4.61  96.990
## 13  3226  4.81  92.590
## 14  3226  5.02  88.380
## 15  3226  5.24  84.360
## 16  3226  5.46  80.530
## 17  3226  5.69  76.870
## 18  3226  5.93  73.370
## 19  3226  6.18  70.040
## 20  3226  6.44  66.850
## 21  3226  6.71  63.820
## 22  3226  6.98  60.920
## 23  3226  7.27  58.150
## 24  3226  7.57  55.500
## 25  3226  7.88  52.980
## 26  3226  8.19  50.570
## 27  3226  8.52  48.270
## 28  3226  8.86  46.080
## 29  3226  9.21  43.990
## 30  3226  9.57  41.990
## 31  3226  9.95  40.080
## 32  3226 10.33  38.260
## 33  3226 10.73  36.520
## 34  3226 11.14  34.860
## 35  3226 11.56  33.270
## 36  3226 11.99  31.760
## 37  3226 12.43  30.320
## 38  3226 12.89  28.940
## 39  3226 13.36  27.620
## 40  3226 13.84  26.370
## 41  3226 14.33  25.170
## 42  3226 14.83  24.030
## 43  3226 15.35  22.930
## 44  3226 15.88  21.890
## 45  3226 16.42  20.900
## 46  3226 16.98  19.950
## 47  3226 17.54  19.040
## 48  3226 18.12  18.180
## 49  3226 18.71  17.350
## 50  3226 19.31  16.560
## 51  3226 19.92  15.810
## 52  3226 20.54  15.090
## 53  3226 21.18  14.400
## 54  3226 21.82  13.750
## 55  3226 22.47  13.120
## 56  3226 23.14  12.530
## 57  3226 23.81  11.960
## 58  3226 24.49  11.410
## 59  3226 25.19  10.900
## 60  3226 25.89  10.400
## 61  3226 26.59   9.928
## 62  3226 27.31   9.476
## 63  3226 28.03   9.046
## 64  3226 28.76   8.635
## 65  3226 29.50   8.242
## 66  3226 30.24   7.868
## 67  3226 30.98   7.510
## 68  3226 31.73   7.169
## 69  3226 32.49   6.843
## 70  3226 33.25   6.532
## 71  3226 34.01   6.235
## 72  3226 34.77   5.952
## 73  3226 35.54   5.681
## 74  3226 36.30   5.423
## 75  3226 37.07   5.176
## 76  3226 37.84   4.941
## 77  3226 38.61   4.716
## 78  3226 39.37   4.502
## 79  3226 40.14   4.297
## 80  3226 40.90   4.102
## 81  3226 41.67   3.916
## 82  3226 42.42   3.738
## 83  3226 43.18   3.568
## 84  3226 43.93   3.406
## 85  3226 44.68   3.251
## 86  3226 45.42   3.103
## 87  3226 46.16   2.962
## 88  3226 46.89   2.827
## 89  3226 47.47   2.699
## 90  3226 48.19   2.576
## 91  3226 48.91   2.459
## 92  3226 49.61   2.347
## 93  3226 50.31   2.241
## 94  3226 51.00   2.139
## 95  3226 51.69   2.042
## 96  3226 52.36   1.949
## 97  3226 53.03   1.860
## 98  3226 53.68   1.776
## 99  3226 54.33   1.695
## 100 3226 54.97   1.618

Cross-Validation

cv_results <- cv.glmnet(x, y,
                        family = "binomial",
                        nfolds = 10)
plot(cv_results)

cv_results
## 
## Call:  cv.glmnet(x = x, y = y, nfolds = 10, family = "binomial") 
## 
## Measure: Binomial Deviance 
## 
##      Lambda Index Measure      SE Nonzero
## min 0.06685    20   1.302 0.02499      18
## 1se 0.08838    14   1.322 0.01970       3
summary(lr_model)
##            Length Class     Mode     
## a0            100 -none-    numeric  
## beta       322600 dgCMatrix S4       
## df            100 -none-    numeric  
## dim             2 -none-    numeric  
## lambda        100 -none-    numeric  
## dev.ratio     100 -none-    numeric  
## nulldev         1 -none-    numeric  
## npasses         1 -none-    numeric  
## jerr            1 -none-    numeric  
## offset          1 -none-    logical  
## classnames      2 -none-    character
## call            5 -none-    call     
## nobs            1 -none-    numeric
best_lambda <- lr_model$lambda.min

# Refit the model with the selected lambda
best_model <- glmnet(x, y, family = "binomial", alpha = 0, lambda = best_lambda)

coefficients(best_model)[,1:12]
## 3227 x 12 sparse Matrix of class "dgCMatrix"
##   [[ suppressing 12 column names 's0', 's1', 's2' ... ]]
##                                                                    
## (Intercept) -1.249001e-16 -1.485397e-06 -1.713617e-06 -1.994138e-06
## ASV1236      3.133071e-38  1.908130e-04  1.998792e-04  2.089003e-04
## ASV0421     -5.547569e-38 -3.350813e-04 -3.510170e-04 -3.666903e-04
## ASV0691     -4.924975e-38 -2.896424e-04 -3.034079e-04 -3.165521e-04
## ASV0899     -1.324028e-39 -1.106490e-06 -1.150181e-06 -8.423284e-07
## ASV1004      6.299724e-38  3.812596e-04  3.993747e-04  4.172514e-04
## ASV1041     -4.258951e-38 -2.601709e-04 -2.725263e-04 -2.848550e-04
## ASV1058      5.855981e-38  3.551137e-04  3.719554e-04  3.886430e-04
## ASV12542     1.842670e-38  1.079264e-04  1.130596e-04  1.179279e-04
## ASV1294      6.764978e-38  4.142677e-04  4.339359e-04  4.536197e-04
## ASV13113     2.351661e-38  1.458535e-04  1.527909e-04  1.598135e-04
## ASV1318      5.929751e-38  3.623411e-04  3.795375e-04  3.967181e-04
## ASV2269     -1.761531e-38 -1.098832e-04 -1.150788e-04 -1.204113e-04
## ASV2542      3.703376e-38  2.338315e-04  2.449298e-04  2.564108e-04
## ASV2660     -3.447239e-38 -2.096052e-04 -2.195201e-04 -2.294065e-04
## ASV2737     -1.456066e-39 -1.367741e-05 -1.428706e-05 -1.518864e-05
## ASV2840      4.606802e-38  2.731776e-04  2.861168e-04  2.986311e-04
## ASV3053      2.609821e-39  1.393020e-05  1.460005e-05  1.514913e-05
## ASV3077      1.430712e-38  8.585485e-05  8.992082e-05  9.390237e-05
## ASV3134      4.753922e-38  2.982834e-04  3.124725e-04  3.270169e-04
## ASV3140      2.100119e-38  1.336623e-04  1.399884e-04  1.466031e-04
## ASV3579      7.918462e-39  5.166155e-05  5.415299e-05  5.676858e-05
## ASV6119     -1.761531e-38 -1.098826e-04 -1.150613e-04 -1.203916e-04
## ASV7557     -1.761531e-38 -1.098825e-04 -1.150525e-04 -1.203821e-04
## ASV8422      1.007031e-38  5.634432e-05  5.906750e-05  6.146692e-05
## ASV1086     -5.080525e-39 -2.910583e-05 -3.048988e-05 -3.176340e-05
## ASV1310      3.341700e-38  2.034198e-04  2.130823e-04  2.226822e-04
## ASV15750    -8.427200e-39 -5.330493e-05 -5.578787e-05 -5.841172e-05
## ASV16905    -1.761531e-38 -1.098822e-04 -1.150488e-04 -1.203771e-04
## ASV2033      3.219968e-38  1.981608e-04  2.076165e-04  2.170776e-04
## ASV2089      1.201683e-38  7.568921e-05  7.924489e-05  8.295371e-05
## ASV2127      4.826544e-38  2.909540e-04  3.047510e-04  3.183362e-04
## ASV2725      5.527505e-38  3.307507e-04  3.464588e-04  3.617712e-04
## ASV2804     -1.761531e-38 -1.098819e-04 -1.150462e-04 -1.203737e-04
## ASV3075      3.447315e-38  2.083974e-04  2.183021e-04  2.280642e-04
## ASV3327      3.161305e-38  1.954205e-04  2.047499e-04  2.141267e-04
## ASV3342      3.467863e-38  2.170442e-04  2.273305e-04  2.378866e-04
## ASV3532     -3.132836e-38 -1.949826e-04 -2.041960e-04 -2.136230e-04
## ASV3600      3.984828e-38  2.436328e-04  2.552341e-04  2.667875e-04
## ASV4013      3.390601e-38  2.047929e-04  2.145219e-04  2.241009e-04
## ASV4136      3.397772e-38  2.063844e-04  2.161372e-04  2.258593e-04
## ASV4195      1.761531e-38  1.098816e-04  1.150333e-04  1.203591e-04
## ASV4407     -1.761531e-38 -1.098815e-04 -1.150246e-04 -1.203496e-04
## ASV4717      1.290371e-39  2.551059e-06  2.738207e-06  2.584375e-06
## ASV6794      1.867634e-38  1.074894e-04  1.126327e-04  1.173874e-04
## ASV8324     -1.761531e-38 -1.098814e-04 -1.150221e-04 -1.203458e-04
## ASV8981     -5.080524e-39 -3.167254e-05 -3.309248e-05 -3.462509e-05
## ASV9859      1.271657e-38  8.098419e-05  8.489415e-05  8.890570e-05
## ASV0936     -2.763764e-38 -1.670378e-04 -1.749991e-04 -1.828183e-04
## ASV12683    -2.597726e-39 -1.968116e-05 -2.056413e-05 -2.169419e-05
## ASV1293      4.103429e-38  2.480806e-04  2.598015e-04  2.714219e-04
## ASV13055    -4.412996e-39 -2.855261e-05 -2.982406e-05 -3.125675e-05
## ASV17063    -1.761531e-38 -1.098810e-04 -1.150065e-04 -1.203283e-04
## ASV2228      1.761531e-38  1.098809e-04  1.149979e-04  1.203189e-04
## ASV2769     -3.595451e-39 -2.294309e-05 -2.394070e-05 -2.507630e-05
## ASV2803      8.703816e-39  4.729126e-05  4.959924e-05  5.153974e-05
## ASV2896      2.186891e-38  1.324738e-04  1.388159e-04  1.450406e-04
## ASV3062      6.184777e-39  3.940477e-05  4.135646e-05  4.330884e-05
## ASV3107      2.630824e-38  1.609503e-04  1.686230e-04  1.762622e-04
## ASV3265      5.341940e-38  3.213072e-04  3.364978e-04  3.514579e-04
## ASV3666     -1.114465e-39 -9.001639e-06 -9.355387e-06 -9.893566e-06
## ASV4497      1.264747e-38  7.556865e-05  7.920834e-05  8.270306e-05
## ASV6914     -6.022177e-39 -4.092110e-05 -4.279554e-05 -4.494452e-05
## ASV0576     -6.389199e-38 -3.785832e-04 -3.965166e-04 -4.138517e-04
## ASV0673      1.553071e-38  1.008247e-04  1.056149e-04  1.106971e-04
## ASV0772      1.888544e-38  1.124757e-04  1.178470e-04  1.230298e-04
## ASV0862     -1.577283e-38 -9.203229e-05 -9.637688e-05 -1.005122e-04
## ASV0898      1.494744e-38  9.645591e-05  1.010492e-04  1.058867e-04
## ASV0910      3.275872e-38  2.084996e-04  2.184185e-04  2.287337e-04
## ASV0964     -2.301490e-38 -1.374197e-04 -1.439205e-04 -1.502662e-04
## ASV10059     1.525478e-38  9.572315e-05  1.003210e-04  1.049947e-04
## ASV10263    -1.761531e-38 -1.098805e-04 -1.150437e-04 -1.203638e-04
## ASV1088      1.737606e-38  1.099024e-04  1.151404e-04  1.205475e-04
## ASV1101      3.039775e-38  1.861197e-04  1.949358e-04  2.037738e-04
## ASV1183      1.927595e-38  1.224131e-04  1.281763e-04  1.342157e-04
## ASV11956     8.034700e-39  4.304382e-05  4.512148e-05  4.685476e-05
## ASV12774    -2.459980e-39 -1.961180e-05 -2.050291e-05 -2.166437e-05
## ASV1321      7.011807e-39  4.626079e-05  4.851095e-05  5.088093e-05
## ASV13793    -1.761531e-38 -1.098803e-04 -1.150331e-04 -1.203513e-04
## ASV14482    -1.373377e-39 -1.250640e-05 -1.306283e-05 -1.386224e-05
## ASV15483     1.217911e-38  7.231745e-05  7.580862e-05  7.913316e-05
## ASV2062      7.731123e-38  4.751823e-04  4.976508e-04  5.203122e-04
## ASV2132      3.470506e-38  2.126693e-04  2.228237e-04  2.329410e-04
## ASV2413      5.051081e-38  3.050367e-04  3.194586e-04  3.337316e-04
## ASV2490      3.356463e-38  2.018648e-04  2.113825e-04  2.207810e-04
## ASV2594      1.808116e-38  1.084470e-04  1.136031e-04  1.186458e-04
## ASV2822     -1.761531e-38 -1.098802e-04 -1.150465e-04 -1.203640e-04
## ASV2863      3.096232e-38  1.890271e-04  1.979086e-04  2.068538e-04
## ASV2910      4.045912e-38  2.405403e-04  2.519731e-04  2.630313e-04
## ASV2980      1.459677e-38  9.109750e-05  9.536405e-05  9.977248e-05
## ASV3307      1.761531e-38  1.098801e-04  1.150317e-04  1.203474e-04
## ASV3474      2.664464e-38  1.679609e-04  1.759765e-04  1.842113e-04
## ASV3502      5.699692e-38  3.475411e-04  3.640307e-04  3.804674e-04
## ASV4236      2.952451e-38  1.762086e-04  1.844724e-04  1.926040e-04
## ASV4842     -9.516024e-39 -6.129490e-05 -6.417784e-05 -6.723812e-05
## ASV4894     -1.761531e-38 -1.098800e-04 -1.150410e-04 -1.203566e-04
## ASV5290      2.150314e-38  1.310240e-04  1.372811e-04  1.434766e-04
## ASV5501      4.076922e-39  2.364198e-05  2.476756e-05  2.582819e-05
## ASV5795      1.425114e-38  8.699871e-05  9.115383e-05  9.527840e-05
## ASV5987     -1.761531e-38 -1.098800e-04 -1.150439e-04 -1.203592e-04
## ASV6267     -1.761531e-38 -1.098799e-04 -1.150352e-04 -1.203498e-04
## ASV6862      3.472093e-38  2.049392e-04  2.146227e-04  2.239674e-04
## ASV7145      6.514140e-39  3.554432e-05  3.722396e-05  3.869644e-05
## ASV7673     -1.761531e-38 -1.098799e-04 -1.150327e-04 -1.203465e-04
## ASV7789      5.781709e-39  3.652998e-05  3.832847e-05  4.012932e-05
## ASV7809     -2.504185e-39 -1.615844e-05 -1.685826e-05 -1.765877e-05
## ASV8002     -1.761531e-38 -1.098798e-04 -1.150255e-04 -1.203385e-04
## ASV8205      1.018531e-38  5.796957e-05  6.078188e-05  6.331894e-05
## ASV9155     -1.330777e-38 -8.336974e-05 -8.725280e-05 -9.129843e-05
## ASV9221     -2.388223e-39 -1.750088e-05 -1.825110e-05 -1.922070e-05
## ASV9311     -1.761531e-38 -1.098798e-04 -1.150130e-04 -1.203241e-04
## ASV9557     -1.761531e-38 -1.098797e-04 -1.150043e-04 -1.203147e-04
## ASV9936     -1.761531e-38 -1.098797e-04 -1.149957e-04 -1.203052e-04
## ASV1445      3.997197e-38  2.472151e-04  2.589931e-04  2.708681e-04
## ASV4232      3.338541e-38  2.066920e-04  2.165692e-04  2.265191e-04
## ASV6479     -8.157800e-40 -2.493097e-06 -2.532985e-06 -2.507023e-06
## ASV0142     -9.010265e-38 -5.403408e-04 -5.658601e-04 -5.909421e-04
## ASV0378     -2.984397e-38 -1.778476e-04 -1.862181e-04 -1.944117e-04
## ASV1122      5.277825e-38  3.255943e-04  3.410660e-04  3.566641e-04
## ASV0123     -8.831622e-38 -5.296978e-04 -5.546679e-04 -5.792579e-04
## ASV2064      9.456684e-39  5.301739e-05  5.548838e-05  5.776865e-05
## ASV4459     -9.719539e-39 -6.191645e-05 -6.481169e-05 -6.786521e-05
## ASV0448      1.423142e-38  9.730411e-05  1.019918e-04  1.071318e-04
## ASV0397      3.967868e-38  2.464117e-04  2.581236e-04  2.699978e-04
## ASV0485      5.602948e-38  3.426509e-04  3.588641e-04  3.751107e-04
## ASV1566      4.654943e-38  2.831909e-04  2.966128e-04  3.099751e-04
## ASV1365      3.010399e-38  1.823497e-04  1.910279e-04  1.995947e-04
## ASV1065      6.170416e-38  3.797311e-04  3.976935e-04  4.158214e-04
## ASV0722     -1.470608e-39 -6.262697e-06 -6.580155e-06 -6.747648e-06
## ASV12660    -2.979446e-38 -1.821147e-04 -1.906855e-04 -1.993044e-04
## ASV0223     -1.235827e-39 -3.031397e-06 -3.188949e-06 -3.106707e-06
## ASV0229      2.730513e-38  1.712747e-04  1.794002e-04  1.877385e-04
## ASV0877     -1.108271e-38 -6.769687e-05 -7.078255e-05 -7.397489e-05
## ASV0983      5.740917e-38  3.500241e-04  3.665447e-04  3.830829e-04
## ASV0626     -1.988713e-38 -1.147856e-04 -1.200539e-04 -1.251382e-04
## ASV4146     -3.218327e-39 -2.169253e-05 -2.261841e-05 -2.373606e-05
## ASV4175     -3.481381e-38 -2.154629e-04 -2.255776e-04 -2.359138e-04
## ASV2082     -2.075558e-39 -1.215953e-05 -1.288176e-05 -1.344948e-05
## ASV2272      2.490583e-38  1.532060e-04  1.605229e-04  1.678489e-04
## ASV2245     -3.017452e-38 -1.869420e-04 -1.957014e-04 -2.046768e-04
## ASV0590     -1.761143e-38 -1.099843e-04 -1.153115e-04 -1.206595e-04
## ASV0217     -3.047970e-38 -1.700610e-04 -1.779596e-04 -1.851798e-04
## ASV0416      2.949399e-38  1.759130e-04  1.841390e-04  1.922388e-04
## ASV1056      3.274151e-38  2.065818e-04  2.165093e-04  2.266467e-04
## ASV7777     -3.002033e-38 -1.881333e-04 -1.969416e-04 -2.060851e-04
## ASV0455      5.747357e-39  3.878293e-05  4.053846e-05  4.255004e-05
## ASV0604      5.799389e-39  4.199783e-05  4.411789e-05  4.645530e-05
## ASV6100     -2.766616e-38 -1.747451e-04 -1.829192e-04 -1.914805e-04
## ASV11359    -3.118370e-38 -1.922464e-04 -2.012274e-04 -2.104055e-04
## ASV6604      2.173846e-38  1.362445e-04  1.427918e-04  1.494398e-04
## ASV5004     -1.832224e-38 -1.147961e-04 -1.201018e-04 -1.256695e-04
## ASV1483     -1.683076e-38 -1.048731e-04 -1.097285e-04 -1.147861e-04
## ASV9773     -3.550227e-38 -2.224048e-04 -2.328051e-04 -2.436099e-04
## ASV4059      2.938087e-39  2.166942e-05  2.278455e-05  2.401895e-05
## ASV1193      5.793652e-38  3.570573e-04  3.740185e-04  3.911103e-04
## ASV4610     -6.006542e-39 -3.358977e-05 -3.507643e-05 -3.649164e-05
## ASV0742     -2.298570e-38 -1.352354e-04 -1.414388e-04 -1.475650e-04
## ASV1502      8.007334e-41 -2.018574e-06 -2.048436e-06 -2.256775e-06
## ASV0195     -5.832160e-39 -3.817775e-05 -4.005520e-05 -4.200836e-05
## ASV1213      1.900259e-38  1.159335e-04  1.212323e-04  1.266999e-04
## ASV1648     -2.634404e-38 -1.651881e-04 -1.728848e-04 -1.809159e-04
## ASV6984     -1.961126e-38 -1.224858e-04 -1.281590e-04 -1.340814e-04
## ASV0396     -1.668481e-38 -8.824550e-05 -9.237634e-05 -9.586264e-05
## ASV4297      3.047471e-38  1.818746e-04  1.905123e-04  1.989174e-04
## ASV2622      6.888392e-38  4.157039e-04  4.353348e-04  4.547717e-04
## ASV3512      9.672295e-39  6.170919e-05  6.476444e-05  6.784317e-05
## ASV2411      2.270339e-38  1.436981e-04  1.504782e-04  1.575400e-04
## ASV2291     -5.441058e-39 -3.259435e-05 -3.430549e-05 -3.583662e-05
## ASV0807      2.604318e-38  1.710813e-04  1.792579e-04  1.879760e-04
## ASV1292      1.555548e-38  9.753626e-05  1.020515e-04  1.067900e-04
## ASV1035      7.560947e-39  4.426924e-05  4.631109e-05  4.829654e-05
## ASV0070     -1.712350e-38 -1.000053e-04 -1.046895e-04 -1.091994e-04
## ASV0255      6.544534e-39  3.876942e-05  4.054103e-05  4.229717e-05
## ASV0057     -7.196267e-38 -4.285801e-04 -4.487127e-04 -4.684465e-04
## ASV0077     -1.116893e-38 -6.375209e-05 -6.671409e-05 -6.951586e-05
## ASV0625      7.103019e-38  4.307026e-04  4.508887e-04  4.711143e-04
## ASV2464      3.477612e-38  2.107082e-04  2.205687e-04  2.304411e-04
## ASV1315      5.946957e-38  3.658819e-04  3.833229e-04  4.008168e-04
## ASV2673      4.308417e-38  2.728501e-04  2.858890e-04  2.993263e-04
## ASV2161      1.768595e-38  1.106146e-04  1.159388e-04  1.213288e-04
## ASV0337     -2.931708e-38 -1.804013e-04 -1.889920e-04 -1.976186e-04
## ASV7680     -3.404884e-38 -2.109050e-04 -2.207863e-04 -2.309086e-04
## ASV0611      7.352171e-38  4.551899e-04  4.768399e-04  4.987329e-04
## ASV3118     -2.500910e-38 -1.563259e-04 -1.636630e-04 -1.712368e-04
## ASV1284      2.644200e-38  1.698133e-04  1.777015e-04  1.861399e-04
## ASV0889      2.055484e-38  1.240192e-04  1.299302e-04  1.357367e-04
## ASV4649     -2.121874e-38 -1.334350e-04 -1.396531e-04 -1.461570e-04
## ASV1108     -2.641951e-38 -1.691723e-04 -1.771590e-04 -1.855655e-04
## ASV0738     -5.908183e-39 -2.232608e-05 -2.328415e-05 -2.363166e-05
## ASV0473      4.155210e-39  2.651319e-05  2.771962e-05  2.902249e-05
## ASV0598     -3.187637e-38 -1.903784e-04 -1.993192e-04 -2.081112e-04
## ASV0429      4.956004e-38  3.021205e-04  3.163934e-04  3.306756e-04
## ASV1549      4.785423e-38  3.029638e-04  3.174044e-04  3.323198e-04
## ASV1203      3.731441e-38  2.270297e-04  2.376808e-04  2.483789e-04
## ASV4532      1.922455e-39  9.742039e-06  1.024191e-05  1.061446e-05
## ASV0274     -3.852814e-38 -2.268601e-04 -2.375678e-04 -2.478942e-04
## ASV0163     -5.515623e-38 -3.265723e-04 -3.417881e-04 -3.567216e-04
## ASV1298      2.242946e-38  1.335094e-04  1.396940e-04  1.458234e-04
## ASV9424     -4.497007e-38 -2.815765e-04 -2.948104e-04 -3.084882e-04
## ASV0412      7.043598e-38  4.306329e-04  4.509837e-04  4.713910e-04
## ASV0284      3.217293e-38  1.916966e-04  2.006555e-04  2.094713e-04
## ASV0620     -2.264305e-38 -1.449064e-04 -1.517342e-04 -1.589238e-04
## ASV0153     -4.777492e-38 -2.976247e-04 -3.118823e-04 -3.262996e-04
## ASV0498      3.908578e-39  3.356086e-05  3.518858e-05  3.726213e-05
## ASV0097      3.406348e-38  2.116342e-04  2.216571e-04  2.318627e-04
## ASV0104     -1.612636e-37 -9.866334e-04 -1.033436e-03 -1.080279e-03
## ASV1282      2.775381e-38  1.740438e-04  1.823287e-04  1.908023e-04
## ASV3883     -1.582262e-38 -9.739174e-05 -1.019674e-04 -1.066007e-04
## ASV0801      1.543506e-38  1.024593e-04  1.072369e-04  1.125044e-04
## ASV1611     -6.138811e-38 -3.785988e-04 -3.964315e-04 -4.145358e-04
## ASV0227     -2.145864e-38 -1.339951e-04 -1.404496e-04 -1.469582e-04
## ASV0833      2.307460e-38  1.483528e-04  1.554610e-04  1.628793e-04
## ASV0718      5.752412e-38  3.576295e-04  3.745335e-04  3.917943e-04
## ASV1139      2.218115e-38  1.345399e-04  1.407152e-04  1.470250e-04
## ASV0766     -1.602961e-38 -9.573937e-05 -1.001708e-04 -1.045799e-04
## ASV2091      7.916680e-38  4.728297e-04  4.950704e-04  5.169244e-04
## ASV1238     -5.836449e-39 -2.519539e-05 -2.627115e-05 -2.693708e-05
## ASV9193     -6.133051e-39 -5.058371e-05 -5.289709e-05 -5.592828e-05
## ASV0290     -5.878822e-39 -3.657106e-05 -3.830559e-05 -4.006726e-05
## ASV0231      6.145335e-38  3.730930e-04  3.906422e-04  4.081818e-04
## ASV0185      8.140561e-39  6.997178e-05  7.346040e-05  7.781979e-05
## ASV2330      1.801334e-38  1.085559e-04  1.136958e-04  1.187700e-04
## ASV3119     -1.890145e-38 -1.245015e-04 -1.304466e-04 -1.368032e-04
## ASV2368     -2.727240e-38 -1.731298e-04 -1.812513e-04 -1.897805e-04
## ASV0122     -2.266189e-38 -1.366210e-04 -1.431297e-04 -1.495280e-04
## ASV1044      3.693122e-38  2.377824e-04  2.491504e-04  2.610585e-04
## ASV0160     -5.622767e-38 -3.319708e-04 -3.474935e-04 -3.626340e-04
## ASV0326      3.500982e-38  2.150877e-04  2.253922e-04  2.356572e-04
## ASV1388      6.164818e-38  3.768329e-04  3.946614e-04  4.125324e-04
## ASV0792      7.055394e-38  4.321274e-04  4.524060e-04  4.729240e-04
## ASV0036     -4.341619e-38 -2.723864e-04 -2.854195e-04 -2.987115e-04
## ASV2125      7.212501e-38  4.432122e-04  4.641907e-04  4.853310e-04
## ASV1075      1.338293e-38  8.438700e-05  8.845959e-05  9.261097e-05
## ASV0390      1.253755e-38  8.649706e-05  9.062149e-05  9.523436e-05
## ASV3790     -5.735622e-38 -3.478524e-04 -3.642354e-04 -3.805749e-04
## ASV1535     -4.340024e-39 -2.934157e-05 -3.072865e-05 -3.224505e-05
## ASV0263      1.187358e-38  7.549861e-05  7.900468e-05  8.272450e-05
## ASV0675      9.307161e-38  5.869000e-04  6.147258e-04  6.434752e-04
## ASV3348      8.656278e-39  5.676206e-05  5.957709e-05  6.248220e-05
## ASV0058     -9.122278e-38 -5.542065e-04 -5.803912e-04 -6.065049e-04
## ASV4142      2.292079e-38  1.369338e-04  1.433300e-04  1.496676e-04
## ASV0059     -7.879787e-38 -4.778106e-04 -5.003371e-04 -5.228036e-04
## ASV0013     -1.637259e-37 -1.000529e-03 -1.047869e-03 -1.095306e-03
## ASV0033     -4.719255e-38 -2.970738e-04 -3.112448e-04 -3.257886e-04
## ASV4354     -2.135964e-38 -1.289855e-04 -1.350251e-04 -1.410479e-04
## ASV0022     -4.986826e-38 -3.137377e-04 -3.286692e-04 -3.440166e-04
## ASV0134     -1.193838e-38 -7.946790e-05 -8.328511e-05 -8.740127e-05
## ASV0415     -1.175890e-38 -6.524544e-05 -6.823674e-05 -7.099703e-05
## ASV10103    -3.511087e-38 -2.175841e-04 -2.277866e-04 -2.382407e-04
## ASV1613      5.799264e-38  3.544322e-04  3.711184e-04  3.879239e-04
## ASV0135     -4.478038e-39 -2.235386e-05 -2.327640e-05 -2.407412e-05
## ASV0469     -7.254312e-38 -4.407074e-04 -4.613551e-04 -4.821060e-04
## ASV0471      4.519901e-38  2.830636e-04  2.964070e-04  3.101684e-04
## ASV0451     -1.173322e-38 -7.552499e-05 -7.920357e-05 -8.299647e-05
## ASV0747      1.684687e-38  1.052262e-04  1.102585e-04  1.153612e-04
## ASV1314     -2.604417e-38 -1.672703e-04 -1.751952e-04 -1.835350e-04
## ASV0425     -8.316441e-38 -4.982203e-04 -5.215712e-04 -5.446734e-04
## ASV0559     -4.740023e-38 -2.809371e-04 -2.940871e-04 -3.069570e-04
## ASV0148     -5.151179e-38 -3.068554e-04 -3.212242e-04 -3.353670e-04
## ASV0129     -2.643876e-38 -1.527733e-04 -1.598546e-04 -1.666589e-04
## ASV1072      2.514587e-38  1.478164e-04  1.547157e-04  1.614246e-04
## ASV2390      1.792174e-38  1.074626e-04  1.125188e-04  1.175095e-04
## ASV0548      5.195657e-38  3.228210e-04  3.381586e-04  3.537505e-04
## ASV0168     -7.970435e-38 -4.809453e-04 -5.035387e-04 -5.260302e-04
## ASV0066     -5.880654e-38 -3.604353e-04 -3.774670e-04 -3.946142e-04
## ASV0468     -2.156339e-38 -1.374983e-04 -1.439289e-04 -1.507360e-04
## ASV0172     -1.376210e-38 -7.536357e-05 -7.876430e-05 -8.189823e-05
## ASV0236     -3.246804e-38 -1.848785e-04 -1.933480e-04 -2.014219e-04
## ASV0250     -7.781599e-40  1.064916e-05  1.140286e-05  1.269085e-05
## ASV0338     -5.609719e-39 -2.150292e-05 -2.234912e-05 -2.272022e-05
## ASV0450     -2.980329e-40  6.505922e-07  6.766473e-07  8.291404e-07
## ASV0377      6.423902e-38  3.962228e-04  4.149100e-04  4.338702e-04
## ASV1022      1.776651e-38  1.123895e-04  1.176451e-04  1.231639e-04
## ASV6174     -4.557312e-39 -2.519413e-05 -2.636194e-05 -2.740783e-05
## ASV0786      7.561788e-39  4.544168e-05  4.753804e-05  4.964216e-05
## ASV0053     -7.710100e-38 -4.754753e-04 -4.979594e-04 -5.207254e-04
## ASV0697     -2.322761e-38 -1.374339e-04 -1.438288e-04 -1.501183e-04
## ASV0785      5.747145e-38  3.534627e-04  3.701702e-04  3.870603e-04
## ASV1967     -3.902972e-38 -2.362602e-04 -2.473833e-04 -2.584532e-04
## ASV0385     -1.854378e-38 -1.077010e-04 -1.127121e-04 -1.175483e-04
## ASV0295     -1.077806e-39 -5.647932e-07 -4.648935e-07 -1.809315e-07
## ASV0072     -6.300848e-38 -3.784808e-04 -3.961695e-04 -4.137835e-04
## ASV0157     -2.674913e-38 -1.542215e-04 -1.613766e-04 -1.682018e-04
## ASV0501      2.719653e-38  1.747943e-04  1.831613e-04  1.918597e-04
## ASV10729    -4.667636e-38 -2.907864e-04 -3.044920e-04 -3.185484e-04
## ASV1470      2.276183e-38  1.302711e-04  1.363659e-04  1.421027e-04
## ASV0050     -1.552864e-37 -9.448499e-04 -9.892959e-04 -1.033872e-03
## ASV0411     -4.571970e-39 -2.609942e-05 -2.726019e-05 -2.841990e-05
## ASV0549      2.846724e-38  1.803219e-04  1.889698e-04  1.978668e-04
## ASV0184      1.803143e-38  1.117796e-04  1.170233e-04  1.223970e-04
## ASV0705      2.127130e-38  1.358633e-04  1.423210e-04  1.490552e-04
## ASV1715      5.451392e-38  3.361116e-04  3.519646e-04  3.680526e-04
## ASV0603      6.303247e-39  4.262458e-05  4.460868e-05  4.683957e-05
## ASV0826      1.883618e-38  1.125511e-04  1.178142e-04  1.230145e-04
## ASV0034     -7.066366e-38 -4.294520e-04 -4.495333e-04 -4.697594e-04
## ASV0838      1.483163e-38  1.002198e-04  1.048840e-04  1.101080e-04
## ASV0614     -4.004712e-38 -2.483288e-04 -2.600223e-04 -2.719717e-04
## ASV0014     -1.504048e-37 -9.164003e-04 -9.594518e-04 -1.002748e-03
## ASV0585     -9.271648e-39 -5.332300e-05 -5.586263e-05 -5.822703e-05
## ASV0016     -1.536910e-37 -9.371017e-04 -9.810617e-04 -1.025367e-03
## ASV5394     -3.851025e-38 -2.406006e-04 -2.519566e-04 -2.636239e-04
## ASV0666      3.316568e-38  2.036369e-04  2.131640e-04  2.228547e-04
## ASV2085      1.443304e-38  8.064250e-05  8.424797e-05  8.768162e-05
## ASV0003     -1.408628e-37 -8.572970e-04 -8.974133e-04 -9.378609e-04
## ASV0346     -4.125123e-39 -1.569904e-05 -1.620287e-05 -1.645486e-05
## ASV0267     -2.302057e-38 -1.395672e-04 -1.459292e-04 -1.524801e-04
## ASV0353      2.834266e-38  1.857057e-04  1.946516e-04  2.040786e-04
## ASV2419      3.995432e-38  2.432256e-04  2.546035e-04  2.660830e-04
## ASV0447      1.710637e-38  1.149951e-04  1.206314e-04  1.266216e-04
## ASV0654      6.042853e-38  3.734896e-04  3.912007e-04  4.091166e-04
## ASV0151      8.512835e-39  5.777364e-05  6.070237e-05  6.374678e-05
## ASV0065     -5.669201e-38 -3.461521e-04 -3.624201e-04 -3.788220e-04
## ASV0527      4.097663e-38  2.533188e-04  2.652083e-04  2.773626e-04
## ASV4055     -1.480477e-38 -9.879033e-05 -1.035023e-04 -1.086177e-04
## ASV0166     -4.804275e-38 -2.823246e-04 -2.954621e-04 -3.082732e-04
## ASV0417     -4.017932e-38 -2.434224e-04 -2.548098e-04 -2.662381e-04
## ASV0078     -3.257390e-38 -1.951716e-04 -2.042386e-04 -2.132946e-04
## ASV0322     -3.965370e-38 -2.336693e-04 -2.445123e-04 -2.551464e-04
## ASV0156     -5.105976e-38 -3.021854e-04 -3.163015e-04 -3.301289e-04
## ASV0648     -4.488601e-38 -2.815331e-04 -2.948211e-04 -3.085289e-04
## ASV0407      3.103441e-39  1.594673e-05  1.675379e-05  1.736664e-05
## ASV2030     -1.031307e-38 -5.908804e-05 -6.186487e-05 -6.445575e-05
## ASV0300      2.546967e-38  1.675588e-04  1.756450e-04  1.841924e-04
## ASV1150     -3.852651e-39 -2.388806e-05 -2.492285e-05 -2.606333e-05
## ASV0958      2.664002e-38  1.720983e-04  1.803443e-04  1.889883e-04
## ASV0216     -4.906846e-38 -2.970148e-04 -3.107864e-04 -3.247076e-04
## ASV0446      6.489840e-38  4.110993e-04  4.306435e-04  4.508679e-04
## ASV0367     -2.295717e-38 -1.401058e-04 -1.466756e-04 -1.533092e-04
## ASV0200     -4.250453e-38 -2.571906e-04 -2.693018e-04 -2.813762e-04
## ASV0334     -2.377183e-38 -1.312540e-04 -1.371040e-04 -1.425932e-04
## ASV1311      3.031849e-38  1.901085e-04  1.989691e-04  2.082250e-04
## ASV0458      3.264472e-38  1.999219e-04  2.093654e-04  2.188590e-04
## ASV1371      9.212320e-40  3.311521e-06  3.485371e-06  3.524488e-06
## ASV0418      3.956423e-38  2.356465e-04  2.467002e-04  2.575574e-04
## ASV0004      4.709975e-38  2.863350e-04  2.998219e-04  3.133206e-04
## ASV1943      3.491045e-38  2.102337e-04  2.201953e-04  2.300059e-04
## ASV1495     -7.505106e-39 -5.146573e-05 -5.406239e-05 -5.680020e-05
## ASV0901     -5.270082e-38 -3.303631e-04 -3.460542e-04 -3.621541e-04
## ASV0628      3.182044e-38  1.948186e-04  2.038882e-04  2.131387e-04
## ASV0400      1.272268e-38  7.663183e-05  8.019290e-05  8.375242e-05
## ASV0116     -4.015755e-38 -2.468226e-04 -2.585522e-04 -2.703340e-04
## ASV0788      3.388298e-38  2.078331e-04  2.176368e-04  2.275228e-04
## ASV0117      2.104939e-38  1.337443e-04  1.401655e-04  1.467727e-04
## ASV3137      6.088051e-39  3.718533e-05  3.894216e-05  4.070913e-05
## ASV0001      5.769339e-38  3.493623e-04  3.656093e-04  3.820059e-04
## ASV1651      3.849282e-38  2.243828e-04  2.347810e-04  2.448570e-04
## ASV1692      3.916604e-38  2.479499e-04  2.597708e-04  2.719704e-04
## ASV0660      2.398237e-38  1.418857e-04  1.483790e-04  1.548412e-04
## ASV0508      3.230712e-39  1.886343e-05  1.973699e-05  2.058756e-05
## ASV1660     -1.583265e-38 -1.002010e-04 -1.050158e-04 -1.099384e-04
## ASV0233      8.806217e-39  5.639613e-05  5.912351e-05  6.193602e-05
## ASV1343     -4.010104e-38 -2.485290e-04 -2.602738e-04 -2.722284e-04
## ASV0209      3.847575e-38  2.347029e-04  2.455844e-04  2.566824e-04
## ASV0193     -4.956363e-38 -2.925623e-04 -3.061270e-04 -3.194692e-04
## ASV0357     -3.708285e-39 -2.267140e-05 -2.360777e-05 -2.467155e-05
## ASV0198      1.029473e-38  6.674760e-05  6.990145e-05  7.325478e-05
## ASV0007      5.469502e-38  3.317701e-04  3.471736e-04  3.627726e-04
## ASV1772     -5.550091e-39 -3.281374e-05 -3.434175e-05 -3.583937e-05
## ASV0009      5.167512e-38  3.133806e-04  3.278948e-04  3.426243e-04
## ASV0006      2.157679e-38  1.261948e-04  1.319045e-04  1.375939e-04
## ASV0011     -5.581552e-38 -3.476957e-04 -3.641205e-04 -3.809398e-04
## ASV0015      3.953436e-38  2.412701e-04  2.526181e-04  2.640382e-04
## ASV0017      4.193162e-38  2.555755e-04  2.675563e-04  2.796364e-04
## ASV0235     -3.262141e-38 -2.010908e-04 -2.105931e-04 -2.202013e-04
## ASV0382      4.625552e-39  3.805427e-05  4.008780e-05  4.239018e-05
## ASV2357      4.986866e-38  3.066749e-04  3.211235e-04  3.357566e-04
## ASV0567     -3.682815e-38 -2.245209e-04 -2.349885e-04 -2.456043e-04
## ASV0165      3.988685e-38  2.466771e-04  2.583012e-04  2.701330e-04
## ASV0005      8.107507e-38  4.899131e-04  5.127984e-04  5.357282e-04
## ASV0384     -4.532717e-39 -2.635055e-05 -2.744689e-05 -2.862139e-05
## ASV0002      1.659396e-38  1.033754e-04  1.083457e-04  1.133524e-04
## ASV3017      4.757079e-38  2.871443e-04  3.004565e-04  3.138786e-04
## ASV0091      1.764900e-38  1.099225e-04  1.151344e-04  1.204472e-04
## ASV0186     -4.797272e-38 -2.936992e-04 -3.075268e-04 -3.214729e-04
## ASV0370      4.710406e-39  3.179425e-05  3.326827e-05  3.493503e-05
## ASV0018      8.430121e-38  5.103113e-04  5.341430e-04  5.580739e-04
## ASV1377      7.378245e-38  4.483244e-04  4.692403e-04  4.903403e-04
## ASV0019      8.439473e-38  5.110415e-04  5.348692e-04  5.588407e-04
## ASV0023      7.066716e-39  3.723640e-05  3.870266e-05  4.015744e-05
## ASV2194      2.682544e-38  1.645285e-04  1.723438e-04  1.801905e-04
## ASV1155     -3.632665e-39 -1.644269e-05 -1.693904e-05 -1.741689e-05
## ASV0510     -3.222010e-38 -1.850802e-04 -1.933826e-04 -2.015493e-04
## ASV2371     -3.120574e-38 -1.855876e-04 -1.943048e-04 -2.028284e-04
## ASV0024      3.056467e-39  1.258259e-05  1.288875e-05  1.316739e-05
## ASV2452      4.023230e-38  2.423734e-04  2.535075e-04  2.648100e-04
## ASV2332      7.898870e-40  4.454049e-06  4.687266e-06  4.896315e-06
## ASV2591      5.921995e-40  9.353665e-06  9.817209e-06  1.056111e-05
## ASV0521      5.271635e-38  3.356814e-04  3.516266e-04  3.682314e-04
## ASV5542      1.600784e-38  1.007314e-04  1.054130e-04  1.103369e-04
## ASV0336     -2.531440e-38 -1.487600e-04 -1.556989e-04 -1.624494e-04
## ASV10102     3.682342e-38  2.273599e-04  2.380547e-04  2.489446e-04
## ASV16823    -3.040027e-38 -1.816058e-04 -1.901545e-04 -1.985402e-04
## ASV3104      3.040027e-38  1.816058e-04  1.901401e-04  1.985254e-04
## ASV0781      1.428856e-38  8.978916e-05  9.392981e-05  9.830947e-05
## ASV10899     1.253085e-38  8.251082e-05  8.648541e-05  9.070610e-05
## ASV11222    -3.040027e-38 -1.816057e-04 -1.901301e-04 -1.985155e-04
## ASV11327    -3.040027e-38 -1.816057e-04 -1.901157e-04 -1.985007e-04
## ASV12458    -3.040027e-38 -1.816057e-04 -1.901014e-04 -1.984859e-04
## ASV1636     -2.490636e-38 -1.473258e-04 -1.541186e-04 -1.608421e-04
## ASV1890     -3.007323e-38 -1.802957e-04 -1.887430e-04 -1.971024e-04
## ASV2898      6.377943e-38  3.901464e-04  4.083080e-04  4.268041e-04
## ASV8328     -6.226076e-39 -3.074176e-05 -3.205837e-05 -3.313068e-05
## ASV0709     -5.198536e-38 -3.162657e-04 -3.309510e-04 -3.458579e-04
## ASV0856      7.771543e-39  5.220046e-05  5.469911e-05  5.741924e-05
## ASV0909     -2.335561e-38 -1.332493e-04 -1.391533e-04 -1.449715e-04
## ASV0937     -4.008191e-38 -2.468551e-04 -2.585640e-04 -2.703633e-04
## ASV11390    -3.040027e-38 -1.816057e-04 -1.900705e-04 -1.984544e-04
## ASV11966     1.420327e-38  8.864796e-05  9.287905e-05  9.717595e-05
## ASV12990     7.819545e-39  4.991026e-05  5.218436e-05  5.465849e-05
## ASV14797     3.089629e-38  1.876378e-04  1.962542e-04  2.050778e-04
## ASV14904    -3.040027e-38 -1.816057e-04 -1.900659e-04 -1.984501e-04
## ASV15304     7.030854e-39  4.543215e-05  4.763947e-05  4.992105e-05
## ASV16696    -3.040027e-38 -1.816057e-04 -1.900538e-04 -1.984376e-04
## ASV1690      1.419706e-38  9.174082e-05  9.617471e-05  1.007830e-04
## ASV2029      8.151639e-38  4.991662e-04  5.224501e-04  5.461442e-04
## ASV2834      4.329441e-38  2.644228e-04  2.768741e-04  2.893921e-04
## ASV4003      1.121142e-38  7.697683e-05  8.073933e-05  8.483649e-05
## ASV4064      2.989265e-38  1.823310e-04  1.909140e-04  1.995361e-04
## ASV4294      9.589711e-39  6.612541e-05  6.935098e-05  7.288309e-05
## ASV4609     -1.530065e-39 -8.970031e-06 -9.447212e-06 -9.848408e-06
## ASV6283     -3.040027e-38 -1.816056e-04 -1.900507e-04 -1.984353e-04
## ASV6491     -3.040027e-38 -1.816056e-04 -1.900364e-04 -1.984205e-04
## ASV7453      1.059821e-38  7.131683e-05  7.478970e-05  7.850883e-05
## ASV7959      1.319226e-39  1.211791e-05  1.278039e-05  1.356726e-05
## ASV8219      3.040027e-38  1.816056e-04  1.900260e-04  1.984100e-04
## ASV8547     -3.040027e-38 -1.816055e-04 -1.900118e-04 -1.983952e-04
## ASV9319      1.938115e-38  1.192701e-04  1.248803e-04  1.305739e-04
## ASV9382     -3.040027e-38 -1.816055e-04 -1.900028e-04 -1.983858e-04
## ASV11516    -3.040027e-38 -1.816055e-04 -1.899886e-04 -1.983710e-04
## ASV14377    -3.040027e-38 -1.816055e-04 -1.899745e-04 -1.983562e-04
## ASV1867      4.243133e-38  2.644953e-04  2.769743e-04  2.897777e-04
## ASV1895     -1.045979e-38 -6.231039e-05 -6.513977e-05 -6.800805e-05
## ASV3168      1.850837e-38  1.116336e-04  1.167676e-04  1.219766e-04
## ASV4449      3.739630e-38  2.256396e-04  2.361050e-04  2.466407e-04
## ASV6596      1.994017e-38  1.316071e-04  1.379751e-04  1.447298e-04
## ASV7492     -1.214220e-38 -6.866030e-05 -7.167701e-05 -7.463527e-05
## ASV9854     -1.586802e-38 -9.325314e-05 -9.752740e-05 -1.017487e-04
## ASV6296      3.040027e-38  1.816054e-04  1.899442e-04  1.983249e-04
## ASV4201      8.213575e-39  5.835409e-05  6.136111e-05  6.456077e-05
## ASV0552      7.091608e-38  4.432578e-04  4.642355e-04  4.857454e-04
## ASV3671     -6.933592e-39 -3.624613e-05 -3.779886e-05 -3.919287e-05
## ASV3529     -7.618069e-39 -4.203533e-05 -4.379078e-05 -4.554131e-05
## ASV1060      1.780419e-38  1.129075e-04  1.182714e-04  1.238409e-04
## ASV0239     -4.212994e-38 -2.473585e-04 -2.586896e-04 -2.698806e-04
## ASV5711     -3.858562e-38 -2.315608e-04 -2.422552e-04 -2.530004e-04
## ASV4152     -5.028716e-38 -3.038987e-04 -3.180465e-04 -3.322610e-04
## ASV1461      4.545945e-38  2.727193e-04  2.852235e-04  2.978739e-04
## ASV2877      3.640261e-38  2.205385e-04  2.308062e-04  2.411530e-04
## ASV0012      2.642182e-38  1.646279e-04  1.725240e-04  1.804946e-04
## ASV9823      1.022522e-38  5.273385e-05  5.510182e-05  5.712244e-05
## ASV0008      2.903262e-38  1.799787e-04  1.885585e-04  1.972246e-04
## ASV7832     -3.117744e-38 -1.892889e-04 -1.980640e-04 -2.069603e-04
## ASV1915      1.884721e-39  1.453690e-05  1.533166e-05  1.617929e-05
## ASV0055      2.110467e-38  1.295340e-04  1.356041e-04  1.417693e-04
## ASV0032      5.174495e-38  3.182277e-04  3.329563e-04  3.481348e-04
## ASV2977     -4.236458e-38 -2.561868e-04 -2.680906e-04 -2.800792e-04
## ASV0466      4.341784e-38  2.584954e-04  2.703848e-04  2.822701e-04
## ASV3866      4.428837e-38  2.757829e-04  2.887837e-04  3.021166e-04
## ASV0040      5.852469e-38  3.618329e-04  3.789791e-04  3.963430e-04
## ASV0496     -2.206917e-39 -2.025217e-05 -2.142206e-05 -2.273831e-05
## ASV0052      7.282631e-38  4.427894e-04  4.634220e-04  4.842789e-04
## ASV3828     -4.522951e-38 -2.767072e-04 -2.895403e-04 -3.026624e-04
## ASV1930      2.768340e-38  1.724932e-04  1.806022e-04  1.889419e-04
## ASV2126      4.533398e-38  2.786916e-04  2.917079e-04  3.049967e-04
## ASV0793      2.607435e-38  1.624860e-04  1.703365e-04  1.782080e-04
## ASV0299     -2.003054e-38 -1.163024e-04 -1.215117e-04 -1.266928e-04
## ASV0208      4.123216e-38  2.638663e-04  2.764347e-04  2.895538e-04
## ASV0511     -2.426196e-38 -1.401264e-04 -1.463814e-04 -1.525897e-04
## ASV1123     -3.131395e-38 -1.832762e-04 -1.916147e-04 -1.998735e-04
## ASV0099     -1.685390e-38 -9.831966e-05 -1.028649e-04 -1.072793e-04
## ASV0752     -2.883957e-39 -2.132435e-05 -2.242819e-05 -2.363655e-05
## ASV0883      1.221272e-40  1.167877e-06  1.268838e-06  1.350132e-06
## ASV0683      3.687287e-38  2.341418e-04  2.452850e-04  2.568434e-04
## ASV4117     -4.545179e-38 -2.736963e-04 -2.863986e-04 -2.991478e-04
## ASV2172      1.665364e-38  1.022156e-04  1.070225e-04  1.118956e-04
## ASV0330     -3.022947e-38 -1.872858e-04 -1.961016e-04 -2.051206e-04
## ASV0728      2.813973e-38  1.682685e-04  1.762921e-04  1.840882e-04
## ASV0499      5.569071e-38  3.540901e-04  3.709364e-04  3.884399e-04
## ASV0120     -6.313502e-38 -3.869041e-04 -4.050074e-04 -4.233847e-04
## ASV1446      6.044190e-39  3.293011e-05  3.431087e-05  3.565411e-05
## ASV17171    -4.305784e-38 -2.631985e-04 -2.754397e-04 -2.879063e-04
## ASV0533      1.169723e-38  7.505609e-05  7.866155e-05  8.240212e-05
## ASV2495     -1.703725e-38 -1.051715e-04 -1.101609e-04 -1.152012e-04
## ASV5582      1.573573e-38  9.156779e-05  9.569328e-05  9.979612e-05
## ASV1488      1.333731e-38  9.229115e-05  9.668644e-05  1.015874e-04
## ASV0682      3.878487e-38  2.469472e-04  2.586897e-04  2.709064e-04
## ASV0068     -1.569197e-39 -1.327735e-05 -1.407600e-05 -1.489705e-05
## ASV1987     -2.040273e-38 -1.306435e-04 -1.369790e-04 -1.434865e-04
## ASV0035      8.741778e-39  4.712766e-05  4.904687e-05  5.093719e-05
## ASV7192     -2.954758e-38 -1.754259e-04 -1.834718e-04 -1.915077e-04
## ASV0873      4.983130e-39  2.665061e-05  2.774500e-05  2.880668e-05
## ASV4749      3.649700e-39  1.724434e-05  1.777253e-05  1.831644e-05
## ASV2174      2.827707e-38  1.612881e-04  1.686144e-04  1.756886e-04
## ASV1476     -2.364743e-38 -1.437480e-04 -1.504985e-04 -1.572720e-04
## ASV0740     -5.655336e-38 -3.553192e-04 -3.721970e-04 -3.895430e-04
## ASV0170      1.225668e-38  7.571096e-05  7.925957e-05  8.288978e-05
## ASV2466     -5.252633e-38 -3.241162e-04 -3.392566e-04 -3.547737e-04
## ASV1709      4.103967e-38  2.498180e-04  2.614230e-04  2.732038e-04
## ASV6170     -3.701779e-38 -2.128933e-04 -2.229287e-04 -2.323773e-04
## ASV3673      4.233390e-38  2.539371e-04  2.659118e-04  2.777301e-04
## ASV1745      3.214905e-39  1.590267e-05  1.665546e-05  1.723721e-05
## ASV0380     -3.001704e-38 -1.700805e-04 -1.780522e-04 -1.854702e-04
## ASV0426     -9.429897e-39 -5.168855e-05 -5.416699e-05 -5.631987e-05
## ASV0202     -1.061039e-38 -5.271781e-05 -5.478559e-05 -5.664562e-05
## ASV6350     -3.682451e-38 -2.137760e-04 -2.238166e-04 -2.334157e-04
## ASV0713     -2.510054e-38 -1.523945e-04 -1.595707e-04 -1.667508e-04
## ASV1822      4.504880e-39  3.015101e-05  3.152317e-05  3.306624e-05
## ASV4569      4.087268e-38  2.466144e-04  2.581365e-04  2.696747e-04
## ASV0030     -8.372670e-39 -5.483193e-05 -5.756273e-05 -6.034441e-05
## ASV0331      1.553491e-38  1.020945e-04  1.070113e-04  1.122253e-04
## ASV2981      3.971736e-38  2.500761e-04  2.618795e-04  2.740955e-04
## ASV0828     -2.616058e-38 -1.666931e-04 -1.746126e-04 -1.828580e-04
## ASV2440      6.289782e-38  3.958041e-04  4.145137e-04  4.338545e-04
## ASV3006     -3.040027e-38 -1.725744e-04 -1.806531e-04 -1.881999e-04
## ASV3875     -3.040027e-38 -1.725743e-04 -1.806396e-04 -1.881867e-04
## ASV4511      1.544893e-38  9.942746e-05  1.041744e-04  1.091458e-04
## ASV4700     -3.040027e-38 -1.725742e-04 -1.806263e-04 -1.881735e-04
## ASV5804     -3.040027e-38 -1.725741e-04 -1.806128e-04 -1.881603e-04
## ASV6826      2.879466e-38  1.833668e-04  1.920604e-04  2.011338e-04
## ASV7280      2.393345e-38  1.516116e-04  1.587731e-04  1.662065e-04
## ASV7535     -3.040027e-38 -1.725739e-04 -1.806052e-04 -1.881535e-04
## ASV0651     -2.961384e-38 -1.785018e-04 -1.866562e-04 -1.949689e-04
## ASV0913      3.794294e-38  2.397244e-04  2.510837e-04  2.628591e-04
## ASV10832    -3.040027e-38 -1.725738e-04 -1.805924e-04 -1.881409e-04
## ASV1117     -5.631066e-38 -3.409692e-04 -3.569841e-04 -3.729978e-04
## ASV11329     1.146426e-38  8.313713e-05  8.723193e-05  9.183052e-05
## ASV13209    -3.629118e-39 -1.101355e-05 -1.144232e-05 -1.143216e-05
## ASV1345      6.318447e-39  4.167074e-05  4.371111e-05  4.581998e-05
## ASV1719     -3.040027e-38 -1.725736e-04 -1.805710e-04 -1.881204e-04
## ASV1886      3.242222e-38  1.968181e-04  2.060046e-04  2.152857e-04
## ASV2158     -9.398753e-39 -4.735831e-05 -4.944854e-05 -5.121795e-05
## ASV2189      3.410635e-38  2.105452e-04  2.204425e-04  2.305358e-04
## ASV2257      2.584074e-38  1.553533e-04  1.627000e-04  1.699519e-04
## ASV2283      3.040027e-38  1.725733e-04  1.805420e-04  1.880912e-04
## ASV2328      3.040027e-38  1.725732e-04  1.805287e-04  1.880780e-04
## ASV2434     -4.282884e-38 -2.544423e-04 -2.663459e-04 -2.780694e-04
## ASV2648      3.040027e-38  1.725730e-04  1.805005e-04  1.880493e-04
## ASV2698      3.969934e-38  2.469916e-04  2.586317e-04  2.705735e-04
## ASV2775      5.017817e-38  2.962196e-04  3.098203e-04  3.233336e-04
## ASV3171      3.040027e-38  1.725728e-04  1.804737e-04  1.880219e-04
## ASV3227      3.740920e-38  2.188728e-04  2.288626e-04  2.387423e-04
## ASV3397      1.862479e-39  1.301832e-05  1.374450e-05  1.442585e-05
## ASV3444      4.180246e-38  2.463463e-04  2.577821e-04  2.690312e-04
## ASV3556      3.040027e-38  1.725725e-04  1.804402e-04  1.879878e-04
## ASV3606     -3.040027e-38 -1.725724e-04 -1.804271e-04 -1.879745e-04
## ASV4190      3.521442e-38  2.170331e-04  2.272747e-04  2.376664e-04
## ASV4197      4.290482e-38  2.516150e-04  2.632849e-04  2.746964e-04
## ASV4722      3.727856e-38  2.263866e-04  2.369751e-04  2.476386e-04
## ASV4765      8.670616e-39  5.698417e-05  5.964630e-05  6.252401e-05
## ASV4809      3.040027e-38  1.725721e-04  1.803952e-04  1.879420e-04
## ASV4846      2.572609e-38  1.608783e-04  1.684186e-04  1.762153e-04
## ASV4903     -9.356722e-39 -4.539714e-05 -4.732798e-05 -4.891844e-05
## ASV4944     -3.040027e-38 -1.725718e-04 -1.803816e-04 -1.879289e-04
## ASV5151     -8.791479e-39 -6.353048e-05 -6.676382e-05 -7.025405e-05
## ASV5413     -3.040027e-38 -1.725717e-04 -1.803715e-04 -1.879190e-04
## ASV5537     -3.040027e-38 -1.725715e-04 -1.803584e-04 -1.879058e-04
## ASV5688      3.040027e-38  1.725714e-04  1.803454e-04  1.878926e-04
## ASV5752      1.243878e-38  8.047345e-05  8.444768e-05  8.846563e-05
## ASV6122     -3.040027e-38 -1.725712e-04 -1.803356e-04 -1.878826e-04
## ASV6135      3.040027e-38  1.725711e-04  1.803226e-04  1.878694e-04
## ASV6188     -3.040027e-38 -1.725709e-04 -1.803096e-04 -1.878562e-04
## ASV6216      4.291012e-38  2.537348e-04  2.653846e-04  2.770036e-04
## ASV6242      3.040027e-38  1.725707e-04  1.802827e-04  1.878284e-04
## ASV6383      3.040027e-38  1.725705e-04  1.802698e-04  1.878152e-04
## ASV6781      3.040027e-38  1.725704e-04  1.802570e-04  1.878019e-04
## ASV6799     -3.040027e-38 -1.725702e-04 -1.802441e-04 -1.877887e-04
## ASV7374     -3.040027e-38 -1.725701e-04 -1.802313e-04 -1.877755e-04
## ASV7539     -3.040027e-38 -1.725699e-04 -1.802185e-04 -1.877623e-04
## ASV8591     -3.040027e-38 -1.725698e-04 -1.802057e-04 -1.877491e-04
## ASV8637      3.040027e-38  1.725696e-04  1.801930e-04  1.877359e-04
## ASV12796    -3.040027e-38 -1.725695e-04 -1.801802e-04 -1.877227e-04
## ASV1934      3.168520e-38  1.970552e-04  2.063213e-04  2.158377e-04
## ASV22549    -2.606906e-40  9.670218e-06  1.051748e-05  1.152407e-05
## ASV29857    -3.040027e-38 -1.725693e-04 -1.801678e-04 -1.877099e-04
## ASV3215      3.810256e-38  2.392691e-04  2.506358e-04  2.623158e-04
## ASV3236     -3.040027e-38 -1.725691e-04 -1.801543e-04 -1.876959e-04
## ASV3954     -3.040027e-38 -1.725690e-04 -1.801416e-04 -1.876827e-04
## ASV4850      3.040027e-38  1.725688e-04  1.801289e-04  1.876694e-04
## ASV5225      3.040027e-38  1.725687e-04  1.801163e-04  1.876562e-04
## ASV5532     -3.040027e-38 -1.725685e-04 -1.801037e-04 -1.876430e-04
## ASV7258      7.356746e-40  1.915640e-05  2.058205e-05  2.222498e-05
## ASV9474     -1.829704e-38 -9.919263e-05 -1.032942e-04 -1.073851e-04
## ASV11857    -3.040027e-38 -1.725682e-04 -1.800863e-04 -1.876251e-04
## ASV1202     -3.040027e-38 -1.725680e-04 -1.800738e-04 -1.876119e-04
## ASV14742     1.797837e-38  1.200694e-04  1.260241e-04  1.322317e-04
## ASV16652     9.184402e-39  6.096820e-05  6.408570e-05  6.719856e-05
## ASV2019      4.207641e-38  2.509927e-04  2.624399e-04  2.740367e-04
## ASV2410     -3.812021e-38 -2.327353e-04 -2.435655e-04 -2.545982e-04
## ASV2718      3.875721e-38  2.468730e-04  2.586857e-04  2.708855e-04
## ASV2738      4.796396e-38  2.820255e-04  2.947610e-04  3.075642e-04
## ASV2876      3.040027e-38  1.725677e-04  1.800462e-04  1.875830e-04
## ASV3177      3.040027e-38  1.725675e-04  1.800337e-04  1.875698e-04
## ASV4367      3.040027e-38  1.725674e-04  1.800212e-04  1.875566e-04
## ASV4635      7.220246e-39  5.694731e-05  6.011270e-05  6.343929e-05
## ASV4896     -4.249857e-40  1.265703e-05  1.383572e-05  1.520452e-05
## ASV4907      1.825889e-38  1.236633e-04  1.299764e-04  1.364454e-04
## ASV5230     -3.040027e-38 -1.725670e-04 -1.800199e-04 -1.875557e-04
## ASV6509     -3.040027e-38 -1.725669e-04 -1.800075e-04 -1.875425e-04
## ASV7376     -3.040027e-38 -1.725668e-04 -1.799950e-04 -1.875293e-04
## ASV8163     -3.040027e-38 -1.725666e-04 -1.799826e-04 -1.875161e-04
## ASV8195     -3.040027e-38 -1.725665e-04 -1.799702e-04 -1.875029e-04
## ASV8923      1.564948e-38  1.032958e-04  1.084568e-04  1.137290e-04
## ASV9666     -2.728745e-38 -1.533035e-04 -1.597881e-04 -1.663947e-04
## ASV1482      2.477237e-38  1.536848e-04  1.610560e-04  1.684482e-04
## ASV2726      3.190156e-38  2.024051e-04  2.121706e-04  2.221352e-04
## ASV3281     -3.040027e-38 -1.725661e-04 -1.799566e-04 -1.874884e-04
## ASV4235     -3.040027e-38 -1.725660e-04 -1.799443e-04 -1.874752e-04
## ASV4808      4.286934e-38  2.531235e-04  2.645285e-04  2.760868e-04
## ASV4861     -4.283689e-38 -2.545215e-04 -2.659620e-04 -2.776749e-04
## ASV5276      4.241240e-38  2.498318e-04  2.610595e-04  2.724293e-04
## ASV5837      3.436592e-38  2.151666e-04  2.253102e-04  2.357860e-04
## ASV7098      3.525946e-38  2.201664e-04  2.304961e-04  2.411844e-04
## ASV8451     -3.040027e-38 -1.725656e-04 -1.798881e-04 -1.874152e-04
## ASV8694     -3.040027e-38 -1.725655e-04 -1.798759e-04 -1.874020e-04
## ASV0905     -1.429364e-38 -9.053140e-05 -9.490064e-05 -9.932495e-05
## ASV2900      3.647573e-38  2.112101e-04  2.203553e-04  2.297881e-04
## ASV3963     -2.964512e-38 -1.678785e-04 -1.749435e-04 -1.822418e-04
## ASV0041     -2.938907e-38 -1.842951e-04 -1.932438e-04 -2.022165e-04
## ASV1865      2.859714e-38  1.874174e-04  1.967012e-04  2.062216e-04
## ASV1140      2.402015e-38  1.505695e-04  1.579443e-04  1.652547e-04
## ASV1179      3.553674e-38  2.225193e-04  2.330878e-04  2.439089e-04
## ASV0279      5.181018e-38  3.145806e-04  3.291163e-04  3.439316e-04
## ASV0043     -3.287927e-39 -2.794899e-05 -2.957691e-05 -3.132549e-05
## ASV2097     -2.989356e-38 -1.770582e-04 -1.849002e-04 -1.930201e-04
## ASV0309     -1.502889e-38 -8.795473e-05 -9.198217e-05 -9.596191e-05
## ASV0607      6.090462e-38  3.829983e-04  4.010643e-04  4.197686e-04
## ASV0025     -6.402158e-38 -4.010868e-04 -4.202133e-04 -4.397201e-04
## ASV2284     -1.239649e-38 -6.460212e-05 -6.744462e-05 -6.995858e-05
## ASV0556      9.864971e-39  6.777759e-05  7.110656e-05  7.469399e-05
## ASV5040      2.597255e-38  1.452080e-04  1.512023e-04  1.574132e-04
## ASV2924     -2.753971e-38 -1.550895e-04 -1.615515e-04 -1.682461e-04
## ASV1331      7.975941e-38  4.873848e-04  5.101771e-04  5.332791e-04
## ASV0506     -3.805681e-38 -2.230897e-04 -2.333538e-04 -2.434482e-04
## ASV1514      5.945817e-38  3.675436e-04  3.847974e-04  4.024206e-04
## ASV2144      5.053533e-38  3.054739e-04  3.197218e-04  3.340268e-04
## ASV2265      6.654328e-38  4.081387e-04  4.272914e-04  4.467073e-04
## ASV5156      1.612468e-38  8.860742e-05  9.255359e-05  9.626218e-05
## ASV5534      1.360131e-38  7.188260e-05  7.499353e-05  7.784243e-05
## ASV5747      1.579865e-53 -1.310712e-05 -1.398069e-05 -1.524880e-05
## ASV6657      3.123704e-38  1.836591e-04  1.921654e-04  2.005127e-04
## ASV0658     -3.561795e-38 -2.093071e-04 -2.188964e-04 -2.283969e-04
## ASV0716      8.915064e-39  5.084476e-05  5.311124e-05  5.533140e-05
## ASV1657      1.640683e-38  8.979463e-05  9.373151e-05  9.746815e-05
## ASV1885      1.244497e-39 -4.139239e-06 -4.594229e-06 -5.369904e-06
## ASV2333      7.434581e-38  4.505179e-04  4.714159e-04  4.925752e-04
## ASV3375      2.871737e-38  1.666158e-04  1.741915e-04  1.816506e-04
## ASV4317      2.845844e-38  1.757865e-04  1.840902e-04  1.925377e-04
## ASV9599      1.711521e-53 -1.310715e-05 -1.402936e-05 -1.529819e-05
## ASV0175     -9.990573e-38 -6.033999e-04 -6.312224e-04 -6.594206e-04
## ASV1032      3.091395e-38  1.796002e-04  1.877159e-04  1.957602e-04
## ASV1235      2.238318e-39  4.954083e-06  4.920541e-06  4.718369e-06
## ASV1262      8.755772e-38  5.319365e-04  5.565925e-04  5.816254e-04
## ASV1320      1.948659e-38  1.306268e-04  1.370525e-04  1.438338e-04
## ASV13797     3.306856e-38  1.978041e-04  2.069209e-04  2.160920e-04
## ASV1491      1.460350e-38  9.973086e-05  1.047230e-04  1.099646e-04
## ASV15014     1.711521e-53 -1.310718e-05 -1.404972e-05 -1.531829e-05
## ASV1510      2.481019e-38  1.621122e-04  1.699291e-04  1.781257e-04
## ASV1551     -1.104080e-38 -6.529902e-05 -6.828828e-05 -7.126945e-05
## ASV1919     -3.858843e-39 -1.031412e-05 -1.048917e-05 -1.032337e-05
## ASV2114      1.713869e-38  9.749063e-05  1.018692e-04  1.061456e-04
## ASV21486     1.711521e-53 -1.310720e-05 -1.404449e-05 -1.531095e-05
## ASV2448      4.569306e-38  2.708204e-04  2.832638e-04  2.956731e-04
## ASV2589      2.237777e-38  1.297648e-04  1.356627e-04  1.414718e-04
## ASV2608      3.614853e-38  2.179384e-04  2.280304e-04  2.382199e-04
## ASV2786      2.875533e-38  1.764020e-04  1.845980e-04  1.930162e-04
## ASV2827      3.773243e-38  2.258882e-04  2.363895e-04  2.468584e-04
## ASV2872      3.188979e-38  1.847219e-04  1.930797e-04  2.013194e-04
## ASV3125      3.747887e-38  2.205167e-04  2.305303e-04  2.405584e-04
## ASV3247      4.057156e-38  2.388180e-04  2.496898e-04  2.605462e-04
## ASV3451      1.711521e-53 -1.310728e-05 -1.411386e-05 -1.538314e-05
## ASV3465     -2.469012e-39 -2.896563e-05 -3.065593e-05 -3.271829e-05
## ASV3809      2.403302e-38  1.394288e-04  1.456320e-04  1.518652e-04
## ASV4006      5.058067e-38  2.963538e-04  3.097826e-04  3.231694e-04
## ASV4046      3.617860e-38  2.128680e-04  2.224716e-04  2.321472e-04
## ASV4938     -2.155665e-40 -1.446025e-05 -1.555416e-05 -1.688957e-05
## ASV5435      1.711521e-53 -1.310736e-05 -1.413582e-05 -1.540482e-05
## ASV5605      1.609979e-38  8.615720e-05  8.986042e-05  9.333540e-05
## ASV5635      1.711521e-53 -1.310739e-05 -1.413939e-05 -1.540779e-05
## ASV5743      4.497092e-38  2.681084e-04  2.804050e-04  2.927829e-04
## ASV6627      1.711521e-53 -1.310742e-05 -1.415149e-05 -1.542016e-05
## ASV6785      1.711521e-53 -1.310743e-05 -1.414972e-05 -1.541792e-05
## ASV7368      4.761317e-38  2.943813e-04  3.081117e-04  3.222544e-04
## ASV9118      1.508129e-38  8.128489e-05  8.476024e-05  8.807566e-05
## ASV9135      1.247077e-38  6.390574e-05  6.651118e-05  6.893045e-05
## ASV9435      2.510395e-38  1.406470e-04  1.467916e-04  1.528111e-04
## ASV9671      1.579865e-53 -1.310751e-05 -1.417183e-05 -1.544031e-05
## ASV0387     -5.040080e-38 -2.975041e-04 -3.110156e-04 -3.245793e-04
## ASV0454     -4.962213e-38 -2.956426e-04 -3.091705e-04 -3.227885e-04
## ASV0751     -3.309851e-38 -1.942836e-04 -2.030193e-04 -2.118193e-04
## ASV1081      1.277394e-38  7.827772e-05  8.199831e-05  8.571127e-05
## ASV1332      2.670614e-38  1.614832e-04  1.689449e-04  1.765023e-04
## ASV2659      4.138730e-38  2.563839e-04  2.684167e-04  2.807160e-04
## ASV2979      4.574727e-38  2.680315e-04  2.800825e-04  2.921911e-04
## ASV4184      2.022738e-38  1.094868e-04  1.140920e-04  1.185696e-04
## ASV6198      1.634206e-38  9.451583e-05  9.873643e-05  1.029584e-04
## ASV7454      2.972525e-38  1.750037e-04  1.828959e-04  1.908489e-04
## ASV8198      1.381746e-38  7.149124e-05  7.432603e-05  7.706595e-05
## ASV0855      6.318760e-38  3.897883e-04  4.079820e-04  4.266415e-04
## ASV10092     2.818463e-38  1.657178e-04  1.731768e-04  1.807122e-04
## ASV1532      3.358332e-38  2.117511e-04  2.218808e-04  2.322576e-04
## ASV2553      8.400286e-38  5.137326e-04  5.376842e-04  5.620489e-04
## ASV2741      3.236422e-38  2.055424e-04  2.154672e-04  2.255918e-04
## ASV4095      1.650114e-38  1.107093e-04  1.163213e-04  1.220521e-04
## ASV5295      2.695222e-38  1.530409e-04  1.596999e-04  1.663644e-04
## ASV5787      1.711521e-53 -1.310768e-05 -1.422215e-05 -1.549236e-05
## ASV9455      3.404879e-38  2.012791e-04  2.103333e-04  2.195355e-04
## ASV10879     3.459155e-38  2.093761e-04  2.189884e-04  2.288242e-04
## ASV3997      2.228766e-38  1.448488e-04  1.518686e-04  1.591544e-04
## ASV6760      9.272111e-39  4.296227e-05  4.442269e-05  4.577634e-05
## ASV6990      2.610804e-38  1.522032e-04  1.589534e-04  1.658058e-04
## ASV9560      1.690264e-38  9.469838e-05  9.875317e-05  1.028203e-04
## ASV0220      1.372524e-38  8.277801e-05  8.674619e-05  9.060814e-05
## ASV2518      3.270863e-38  2.014420e-04  2.109046e-04  2.205352e-04
## ASV3615      5.255024e-38  3.179047e-04  3.325277e-04  3.474303e-04
## ASV0075      1.248383e-38  6.953282e-05  7.265708e-05  7.560168e-05
## ASV8070      8.545617e-39  3.991178e-05  4.125582e-05  4.253385e-05
## ASV1658      2.564588e-38  1.509866e-04  1.578059e-04  1.646790e-04
## ASV0773      4.147203e-38  2.438287e-04  2.549555e-04  2.660261e-04
## ASV0799      1.308621e-39  7.829133e-06  8.168069e-06  8.529415e-06
## ASV1839     -9.031958e-39 -4.862145e-05 -5.075421e-05 -5.270749e-05
## ASV0265      3.621898e-38  2.323905e-04  2.437675e-04  2.553494e-04
## ASV3741      1.552936e-38  9.442072e-05  9.874234e-05  1.031866e-04
## ASV0847      5.380913e-38  3.279087e-04  3.432323e-04  3.587160e-04
## ASV1026      5.791672e-38  3.505819e-04  3.668180e-04  3.832451e-04
## ASV1222     -2.006763e-38 -1.122955e-04 -1.169537e-04 -1.217549e-04
## ASV0729      7.995788e-39  4.789632e-05  5.015811e-05  5.237726e-05
## ASV0143     -4.554584e-38 -2.674544e-04 -2.795297e-04 -2.916425e-04
## ASV1328      1.197601e-38  6.842314e-05  7.183630e-05  7.485240e-05
## ASV9078     -8.638951e-39 -6.724196e-05 -7.097660e-05 -7.488422e-05
## ASV0027     -6.129045e-38 -3.822378e-04 -4.004185e-04 -4.189163e-04
## ASV0546     -2.867009e-38 -1.683360e-04 -1.758638e-04 -1.834892e-04
## ASV1136      7.053137e-38  4.274327e-04  4.471782e-04  4.672605e-04
## ASV3081      3.320036e-38  2.037776e-04  2.132480e-04  2.229718e-04
## ASV0531      1.394782e-38  8.983440e-05  9.428129e-05  9.876279e-05
## ASV2525      1.990986e-38  1.174237e-04  1.226898e-04  1.280404e-04
## ASV1083     -8.493520e-39 -4.519635e-05 -4.694064e-05 -4.875326e-05
## ASV0424      1.227119e-38  7.597790e-05  7.952276e-05  8.317674e-05
## ASV0644     -1.733463e-53  8.944656e-06  9.813264e-06  1.067708e-05
## ASV6007      1.492095e-53 -1.316383e-05 -1.433828e-05 -1.561887e-05
## ASV0564      1.585796e-38  1.042190e-04  1.094131e-04  1.147161e-04
## ASV1938      2.007382e-38  1.145547e-04  1.194600e-04  1.244830e-04
## ASV6516     -4.277777e-38 -2.605948e-04 -2.727075e-04 -2.850054e-04
## ASV0503     -5.241223e-38 -3.071616e-04 -3.208252e-04 -3.346931e-04
## ASV6913     -5.220210e-38 -3.050436e-04 -3.188128e-04 -3.325655e-04
## ASV0164     -3.805648e-38 -2.412070e-04 -2.526404e-04 -2.645213e-04
## ASV1576      4.761563e-38  2.896899e-04  3.030789e-04  3.167547e-04
## ASV1725      2.125365e-38  1.391690e-04  1.461473e-04  1.532099e-04
## ASV4501      2.183865e-38  1.238216e-04  1.290805e-04  1.344576e-04
## ASV10678    -4.213446e-38 -2.544687e-04 -2.662559e-04 -2.781491e-04
## ASV0944      3.325204e-38  2.108598e-04  2.208963e-04  2.312814e-04
## ASV2292      5.476757e-38  3.304445e-04  3.456151e-04  3.610502e-04
## ASV1090      3.521312e-38  2.161516e-04  2.261170e-04  2.364122e-04
## ASV9117     -1.897843e-38 -1.065290e-04 -1.109518e-04 -1.155261e-04
## ASV0285     -1.878554e-38 -1.260999e-04 -1.325612e-04 -1.391144e-04
## ASV0463     -3.568047e-38 -2.117619e-04 -2.212069e-04 -2.309027e-04
## ASV3199      3.134678e-38  1.829364e-04  1.909989e-04  1.992294e-04
## ASV0150     -1.103024e-38 -7.374472e-05 -7.743546e-05 -8.124885e-05
## ASV6583     -1.892061e-38 -1.089354e-04 -1.135044e-04 -1.183361e-04
## ASV0392      2.792587e-38  1.727913e-04  1.807996e-04  1.890945e-04
## ASV14007    -3.459648e-38 -2.094126e-04 -2.190062e-04 -2.288122e-04
## ASV0177     -1.987566e-38 -1.160522e-04 -1.211068e-04 -1.263264e-04
## ASV6448     -1.213724e-38 -8.793902e-05 -9.268934e-05 -9.754719e-05
## ASV5399     -3.657760e-39 -3.557555e-05 -3.782245e-05 -4.017126e-05
## ASV0277     -6.815782e-39 -4.295861e-05 -4.500913e-05 -4.711188e-05
## ASV2599      1.458945e-38  7.306914e-05  7.601113e-05  7.867132e-05
## ASV13465    -1.217653e-38 -5.884158e-05 -6.109988e-05 -6.310488e-05
## ASV2412      1.749340e-38  1.081579e-04  1.132039e-04  1.183881e-04
## ASV0423      3.278161e-38  2.125327e-04  2.228266e-04  2.335446e-04
## ASV5187      2.373825e-38  1.335361e-04  1.391252e-04  1.448774e-04
## ASV0701     -8.100065e-38 -4.975814e-04 -5.210554e-04 -5.447622e-04
## ASV4248      1.808802e-38  1.181978e-04  1.241834e-04  1.301695e-04
## ASV0519      3.303489e-38  2.087612e-04  2.187688e-04  2.290025e-04
## ASV0764      4.817093e-39  3.545405e-05  3.731153e-05  3.929720e-05
## ASV5385     -4.230483e-38 -2.616983e-04 -2.740295e-04 -2.865898e-04
## ASV3021     -2.693519e-38 -1.488176e-04 -1.552319e-04 -1.614949e-04
## ASV4119     -1.533501e-38 -8.315562e-05 -8.659678e-05 -9.001134e-05
## ASV2534      7.307864e-39  4.298602e-05  4.476134e-05  4.671637e-05
## ASV1061      2.986485e-38  2.000454e-04  2.099752e-04  2.203747e-04
## ASV0670      4.508419e-38  2.789715e-04  2.921377e-04  3.055315e-04
## ASV1384      1.797613e-38  1.204297e-04  1.264811e-04  1.327217e-04
## ASV1981      4.151370e-38  2.596336e-04  2.720296e-04  2.846304e-04
## ASV9632     -1.643466e-38 -8.702391e-05 -9.039257e-05 -9.384559e-05
## ASV4564      1.012326e-38  6.395345e-05  6.702284e-05  7.016001e-05
## ASV5289     -9.454109e-39 -5.792748e-05 -6.071311e-05 -6.346663e-05
## ASV0516      8.568451e-38  5.289000e-04  5.537500e-04  5.790678e-04
## ASV1463     -3.200516e-38 -1.909489e-04 -1.997050e-04 -2.085029e-04
## ASV0969      1.511912e-38  8.888331e-05  9.288258e-05  9.690285e-05
## ASV1113     -3.998190e-38 -2.464676e-04 -2.579778e-04 -2.697664e-04
## ASV1234      4.394788e-40 -8.248313e-06 -9.121631e-06 -1.009317e-05
## ASV3814      8.595295e-39  3.828842e-05  3.932805e-05  4.042528e-05
## ASV1000      4.186067e-38  2.521918e-04  2.638128e-04  2.755640e-04
## ASV0079     -2.429104e-39 -2.196674e-05 -2.324387e-05 -2.465783e-05
## ASV0145      1.504519e-38  8.596624e-05  8.964981e-05  9.342236e-05
## ASV0457     -5.317495e-38 -3.176915e-04 -3.322841e-04 -3.469586e-04
## ASV1485      1.628540e-38  1.032176e-04  1.081614e-04  1.132510e-04
## ASV0535     -1.188618e-38 -7.024470e-05 -7.324725e-05 -7.646266e-05
## ASV0259     -3.416494e-38 -2.077307e-04 -2.174331e-04 -2.272085e-04
## ASV0570      1.362727e-39  1.500469e-05  1.593981e-05  1.699075e-05
## ASV0906      4.485730e-38  2.703818e-04  2.827877e-04  2.953964e-04
## ASV1748     -2.368600e-38 -1.585193e-04 -1.664518e-04 -1.746533e-04
## ASV5520     -1.289010e-38 -9.342880e-05 -9.836258e-05 -1.035271e-04
## ASV2288     -5.252116e-38 -3.100395e-04 -3.243658e-04 -3.384920e-04
## ASV1887     -7.553707e-39 -5.789006e-05 -6.114277e-05 -6.446759e-05
## ASV0374     -1.691508e-38 -9.861602e-05 -1.029832e-04 -1.074102e-04
## ASV0823      5.133624e-38  3.056316e-04  3.194256e-04  3.334919e-04
## ASV0717      2.460724e-38  1.532375e-04  1.604718e-04  1.678784e-04
## ASV0431      1.787548e-38  1.059518e-04  1.108300e-04  1.156763e-04
## ASV1030      6.998089e-38  4.429723e-04  4.641764e-04  4.859491e-04
## ASV1082     -1.049765e-38 -6.481477e-05 -6.787919e-05 -7.098440e-05
## ASV2684      4.864533e-39  4.034361e-05  4.269862e-05  4.513582e-05
## ASV0051      6.303534e-38  3.940649e-04  4.126428e-04  4.317829e-04
## ASV0513      2.399094e-39  1.640242e-05  1.732493e-05  1.819872e-05
## ASV0581      8.083178e-38  5.000207e-04  5.236258e-04  5.476298e-04
## ASV7282      1.252159e-38  8.709804e-05  9.148923e-05  9.617276e-05
## ASV3009     -4.453000e-38 -2.742458e-04 -2.871137e-04 -3.002152e-04
## ASV2106     -2.406350e-38 -1.398568e-04 -1.460287e-04 -1.522925e-04
## ASV1012      1.317516e-38  8.750649e-05  9.187733e-05  9.637869e-05
## ASV0921     -1.329964e-39 -6.037004e-06 -6.208335e-06 -6.383627e-06
## ASV0010     -6.226606e-38 -3.907565e-04 -4.093177e-04 -4.283532e-04
## ASV1178      7.543074e-40  7.830310e-06  8.384244e-06  8.911648e-06
## ASV2848     -3.520821e-38 -2.107973e-04 -2.203596e-04 -2.301359e-04
## ASV0586      9.140052e-38  5.671037e-04  5.938730e-04  6.211864e-04
## ASV4225      1.525470e-39  1.592771e-05  1.741642e-05  1.849365e-05
## ASV2156     -3.821022e-38 -2.363908e-04 -2.475686e-04 -2.589250e-04
## ASV9778     -2.456204e-38 -1.492589e-04 -1.561822e-04 -1.632028e-04
## ASV0493     -5.482259e-38 -3.307638e-04 -3.458835e-04 -3.613355e-04
## ASV3770      1.078128e-38  6.123855e-05  6.361122e-05  6.628224e-05
## ASV0470      6.543959e-38  4.029777e-04  4.217837e-04  4.410323e-04
## ASV0262     -2.508091e-38 -1.669824e-04 -1.753633e-04 -1.839821e-04
## ASV0998      3.970297e-38  2.469361e-04  2.585783e-04  2.705038e-04
## ASV7708     -1.132383e-38 -6.771595e-05 -7.070989e-05 -7.383282e-05
## ASV0453     -1.537160e-39 -8.597337e-06 -8.917851e-06 -9.295299e-06
## ASV0044      8.214650e-38  5.077369e-04  5.313921e-04  5.557378e-04
## ASV5490      1.344841e-38  7.981807e-05  8.346625e-05  8.711585e-05
## ASV2638      2.997621e-39  2.140662e-05  2.263759e-05  2.379406e-05
## ASV0829     -8.594898e-39 -4.591937e-05 -4.775810e-05 -4.960997e-05
## ASV0601      1.439565e-38  9.319621e-05  9.767368e-05  1.023637e-04
## ASV0234      3.600485e-38  2.204087e-04  2.307790e-04  2.412414e-04
## ASV0133      4.698288e-38  2.912832e-04  3.049256e-04  3.189431e-04
## ASV0323      4.881431e-38  3.084750e-04  3.231806e-04  3.383393e-04
## ASV0854     -4.381738e-39 -2.368470e-05 -2.470363e-05 -2.566212e-05
## ASV0110      6.238672e-38  3.906244e-04  4.090704e-04  4.280694e-04
## ASV0816      3.647516e-39  2.131369e-05  2.224160e-05  2.320239e-05
## ASV1031     -1.048331e-38 -6.162478e-05 -6.426807e-05 -6.707537e-05
## ASV0144     -2.607409e-38 -1.594319e-04 -1.668913e-04 -1.744508e-04
## ASV0020     -1.028366e-38 -7.229652e-05 -7.599925e-05 -7.993702e-05
## ASV0962     -2.122252e-38 -1.304761e-04 -1.365708e-04 -1.427899e-04
## ASV0794      3.963597e-38  2.565265e-04  2.690079e-04  2.818910e-04
## ASV7117     -2.141849e-38 -1.330556e-04 -1.391574e-04 -1.455696e-04
## ASV1008     -1.467436e-38 -9.458305e-05 -9.914547e-05 -1.038852e-04
## ASV0096      6.715224e-38  4.207864e-04  4.406090e-04  4.610885e-04
## ASV0128     -3.897035e-38 -2.513356e-04 -2.634956e-04 -2.761086e-04
## ASV5232      3.027018e-38  1.905172e-04  1.997426e-04  2.090524e-04
## ASV0031      2.765044e-39  1.238311e-05  1.285817e-05  1.320685e-05
## ASV1744     -4.501257e-39 -2.899387e-05 -3.030765e-05 -3.177946e-05
## ASV0289      3.767706e-38  2.343810e-04  2.453711e-04  2.567016e-04
## ASV7413     -6.380907e-39 -5.167536e-05 -5.465581e-05 -5.774071e-05
## ASV0822     -4.716991e-38 -2.831309e-04 -2.960276e-04 -3.091723e-04
## ASV8111     -4.169062e-38 -2.397472e-04 -2.505946e-04 -2.612070e-04
## ASV0687      2.759518e-38  1.756401e-04  1.841272e-04  1.928026e-04
## ASV0112      1.120695e-38  5.612154e-05  5.858686e-05  6.059212e-05
## ASV0987      2.225322e-38  1.415524e-04  1.483957e-04  1.553982e-04
## ASV5332     -1.411156e-38 -7.879867e-05 -8.192982e-05 -8.530049e-05
## ASV1129     -2.973524e-38 -1.854159e-04 -1.941085e-04 -2.030984e-04
## ASV1274     -9.717767e-39 -6.083293e-05 -6.366813e-05 -6.662352e-05
## ASV0119      5.478743e-38  3.428676e-04  3.589964e-04  3.756585e-04
## ASV0890      1.342358e-38  8.665964e-05  9.076379e-05  9.510379e-05
## ASV0848      7.928293e-38  4.918982e-04  5.150680e-04  5.387547e-04
## ASV5944     -4.378588e-38 -2.575337e-04 -2.694943e-04 -2.811856e-04
## ASV19741    -4.182093e-38 -2.578389e-04 -2.697671e-04 -2.820947e-04
## ASV0504     -4.911402e-38 -2.959993e-04 -3.094858e-04 -3.232954e-04
## ASV2146     -3.209636e-38 -1.942896e-04 -2.029916e-04 -2.121191e-04
## ASV0089     -2.517405e-38 -1.614460e-04 -1.690786e-04 -1.771139e-04
## ASV2301     -2.729800e-38 -1.710809e-04 -1.791937e-04 -1.875238e-04
## ASV2982      7.442762e-39  5.056217e-05  5.362165e-05  5.626445e-05
## ASV0891     -3.502569e-38 -2.167956e-04 -2.269017e-04 -2.373137e-04
## ASV0093      5.691894e-38  3.519390e-04  3.684341e-04  3.853249e-04
## ASV0042      2.755813e-38  1.667474e-04  1.745376e-04  1.823540e-04
## ASV0980      3.856416e-38  2.338034e-04  2.445295e-04  2.555019e-04
## ASV0069     -8.801954e-39 -5.872488e-05 -6.156334e-05 -6.460488e-05
## ASV1364     -6.623203e-39 -4.177961e-05 -4.363625e-05 -4.568022e-05
## ASV0524     -1.027609e-38 -6.777714e-05 -7.104838e-05 -7.452374e-05
## ASV0435      7.471152e-38  4.651475e-04  4.870957e-04  5.095828e-04
## ASV0517     -3.056280e-38 -1.889391e-04 -1.978598e-04 -2.069251e-04
## ASV3167     -1.268383e-38 -8.125344e-05 -8.527669e-05 -8.931771e-05
## ASV4280     -4.995943e-39 -3.421541e-05 -3.571563e-05 -3.752792e-05
## ASV1158      1.708228e-38  1.129040e-04  1.185896e-04  1.243595e-04
## ASV2214      1.425520e-38  8.824133e-05  9.223648e-05  9.649854e-05
## ASV0544     -1.668881e-38 -1.043649e-04 -1.093905e-04 -1.144643e-04
## ASV5326     -3.187033e-39 -1.899559e-05 -1.989385e-05 -2.076995e-05
## ASV3765     -4.494004e-38 -2.717373e-04 -2.844555e-04 -2.971753e-04
## ASV4646      6.121052e-40 -5.882625e-06 -6.528955e-06 -7.287419e-06
## ASV0090      5.184869e-39  2.753818e-05  2.870504e-05  2.979222e-05
## ASV3680      4.341329e-38  2.571004e-04  2.686152e-04  2.803629e-04
## ASV0111      7.565369e-39  4.281703e-05  4.470479e-05  4.655366e-05
## ASV0768      2.548455e-38  1.590531e-04  1.666524e-04  1.743689e-04
## ASV4862     -1.739272e-39 -9.497676e-06 -9.829045e-06 -1.021573e-05
## ASV1742     -3.551583e-38 -2.109998e-04 -2.204405e-04 -2.301326e-04
## ASV3701     -5.809251e-39 -3.709101e-05 -3.857695e-05 -4.041583e-05
## ASV2386     -2.065815e-38 -1.266135e-04 -1.326265e-04 -1.386416e-04
## ASV0375     -4.939936e-38 -2.967005e-04 -3.102367e-04 -3.240284e-04
## ASV2796      1.334889e-38  7.937735e-05  8.285278e-05  8.650780e-05
## ASV1369      3.408110e-38  2.050180e-04  2.143460e-04  2.239043e-04
## ASV10272    -3.040027e-38 -1.853784e-04 -1.940641e-04 -2.028212e-04
## ASV10354    -3.040027e-38 -1.853783e-04 -1.940495e-04 -2.028057e-04
## ASV1067     -2.322149e-39 -1.569491e-05 -1.648584e-05 -1.730845e-05
## ASV1900      6.222341e-38  3.878496e-04  4.061452e-04  4.249160e-04
## ASV4079     -1.036164e-38 -6.630667e-05 -6.955798e-05 -7.285158e-05
## ASV4149      4.409513e-38  2.617254e-04  2.735282e-04  2.855183e-04
## ASV5140     -3.040027e-38 -1.853784e-04 -1.940348e-04 -2.027902e-04
## ASV10782    -1.804520e-39 -8.662818e-06 -8.961098e-06 -9.241919e-06
## ASV4273     -7.479188e-39 -4.281040e-05 -4.472787e-05 -4.659850e-05
## ASV8121      2.868455e-38  1.786944e-04  1.870621e-04  1.957097e-04
## ASV8438     -3.040027e-38 -1.853784e-04 -1.940216e-04 -2.027764e-04
## ASV9390     -3.040027e-38 -1.853784e-04 -1.940070e-04 -2.027609e-04
## ASV1340      4.093787e-38  2.564319e-04  2.685811e-04  2.810551e-04
## ASV2650     -4.569051e-38 -2.756203e-04 -2.882832e-04 -3.011406e-04
## ASV4674      2.278712e-38  1.409291e-04  1.475009e-04  1.542603e-04
## ASV10492    -1.805289e-39 -1.211485e-05 -1.265983e-05 -1.328681e-05
## ASV11430    -3.040027e-38 -1.853783e-04 -1.939853e-04 -2.027379e-04
## ASV12135    -3.040027e-38 -1.853783e-04 -1.939708e-04 -2.027224e-04
## ASV14970    -3.040027e-38 -1.853783e-04 -1.939563e-04 -2.027069e-04
## ASV1954      3.415967e-38  2.112806e-04  2.211984e-04  2.313350e-04
## ASV2613      5.369877e-38  3.303344e-04  3.457179e-04  3.614749e-04
## ASV2757      2.209087e-38  1.309910e-04  1.369119e-04  1.429090e-04
## ASV2909     -3.113541e-38 -1.933122e-04 -2.024786e-04 -2.117968e-04
## ASV2954     -6.464487e-39 -3.740765e-05 -3.910658e-05 -4.076421e-05
## ASV2969      2.886375e-38  1.821552e-04  1.908583e-04  1.997947e-04
## ASV3410      5.666365e-39  3.896485e-05  4.088103e-05  4.295818e-05
## ASV3575      1.564300e-38  9.706354e-05  1.015692e-04  1.062495e-04
## ASV4275      3.536200e-38  2.109238e-04  2.205280e-04  2.302447e-04
## ASV4652      5.307887e-39  3.673501e-05  3.854750e-05  4.051137e-05
## ASV4761      3.526201e-38  2.106995e-04  2.203063e-04  2.300270e-04
## ASV6003      2.522470e-38  1.622834e-04  1.700900e-04  1.782131e-04
## ASV6110     -3.040027e-38 -1.853784e-04 -1.939872e-04 -2.027404e-04
## ASV7427      1.959506e-38  1.212076e-04  1.268232e-04  1.326394e-04
## ASV8092     -3.040027e-38 -1.853784e-04 -1.939778e-04 -2.027304e-04
## ASV8169     -3.040027e-38 -1.853783e-04 -1.939632e-04 -2.027149e-04
## ASV9693      1.301781e-38  8.097959e-05  8.477749e-05  8.868664e-05
## ASV10913     1.384640e-38  8.908529e-05  9.336456e-05  9.782074e-05
## ASV1979     -5.120549e-39 -3.032805e-05 -3.167850e-05 -3.306300e-05
## ASV3772      3.780361e-38  2.300183e-04  2.406049e-04  2.514483e-04
## ASV0113      7.657695e-39  4.353722e-05  4.552389e-05  4.741470e-05
## ASV1800     -2.968267e-39 -1.971279e-05 -2.061949e-05 -2.161922e-05
## ASV2335     -4.067643e-38 -2.341268e-04 -2.447369e-04 -2.551104e-04
## ASV0692      1.261345e-38  7.973656e-05  8.348993e-05  8.739958e-05
## ASV1120      1.632735e-38  1.006886e-04  1.054214e-04  1.102378e-04
## ASV1434     -8.658433e-38 -5.340603e-04 -5.591700e-04 -5.847326e-04
## ASV0076     -9.294980e-39 -6.173762e-05 -6.469961e-05 -6.788244e-05
## ASV0361      6.463148e-38  4.042469e-04  4.232798e-04  4.429121e-04
## ASV2231     -2.017176e-38 -1.352460e-04 -1.419476e-04 -1.489911e-04
## ASV2018     -8.523333e-40 -1.088400e-05 -1.141925e-05 -1.223543e-05
## ASV1529      5.329279e-38  3.352546e-04  3.512153e-04  3.676064e-04
## ASV0841     -3.123463e-39 -1.707194e-05 -1.777216e-05 -1.847247e-05
## ASV2556     -3.299648e-38 -2.019538e-04 -2.113311e-04 -2.209063e-04
## ASV2777      4.323659e-38  2.559220e-04  2.673948e-04  2.790802e-04
## ASV0355      3.338025e-38  2.094970e-04  2.193381e-04  2.295529e-04
## ASV5169     -4.675239e-38 -2.868418e-04 -3.002743e-04 -3.139183e-04
## ASV3091      2.191844e-38  1.403325e-04  1.470333e-04  1.540195e-04
## ASV2435      3.323790e-38  2.025344e-04  2.120003e-04  2.215573e-04
## ASV6822     -2.143986e-38 -1.308626e-04 -1.368838e-04 -1.430648e-04
## ASV12605    -5.095941e-38 -3.131735e-04 -3.278025e-04 -3.427225e-04
## ASV0286     -3.410740e-38 -2.095438e-04 -2.192488e-04 -2.292473e-04
## ASV0074     -4.693796e-40 -1.225887e-05 -1.304667e-05 -1.412293e-05
## ASV2485     -2.061041e-39 -8.558711e-06 -9.067719e-06 -9.282316e-06
## ASV1233     -6.447314e-38 -4.001118e-04 -4.189016e-04 -4.381870e-04
## ASV0356     -3.150438e-38 -1.914448e-04 -2.002177e-04 -2.092372e-04
## ASV2918     -3.966520e-38 -2.318929e-04 -2.426145e-04 -2.530675e-04
## ASV1427      3.429366e-40 -1.453952e-07 -2.040126e-07 -3.313699e-07
## ASV1409      3.677986e-38  2.341008e-04  2.452343e-04  2.568207e-04
## ASV0770      1.280859e-38  7.232359e-05  7.556794e-05  7.866848e-05
## ASV1403     -4.569919e-38 -2.811551e-04 -2.942369e-04 -3.076506e-04
## ASV0314     -2.459058e-38 -1.525190e-04 -1.596627e-04 -1.669987e-04
## ASV0187      1.384455e-39  3.483776e-06  3.439930e-06  3.349875e-06
## ASV0313     -3.380405e-38 -2.041821e-04 -2.136679e-04 -2.232177e-04
## ASV1087      5.713278e-38  3.559093e-04  3.725865e-04  3.897994e-04
## ASV1970      3.456843e-39  1.893373e-05  1.978844e-05  2.057038e-05
## ASV0754      4.598408e-38  2.863718e-04  2.998210e-04  3.136700e-04
## ASV3775     -3.094402e-38 -1.950671e-04 -2.043284e-04 -2.138856e-04
## ASV0132      1.337278e-38  8.005818e-05  8.379955e-05  8.750100e-05
## ASV2329     -7.242003e-39 -5.533575e-05 -5.828220e-05 -6.145910e-05
## ASV0561      4.041917e-38  2.448212e-04  2.561990e-04  2.676759e-04
## ASV0130     -4.822305e-38 -2.993822e-04 -3.135068e-04 -3.279280e-04
## ASV0226      5.486676e-38  3.397569e-04  3.556913e-04  3.720157e-04
## ASV12648    -3.957854e-38 -2.414511e-04 -2.524970e-04 -2.639267e-04
## ASV0204      5.471322e-38  3.387163e-04  3.545740e-04  3.708416e-04
## ASV0767      1.032003e-38  5.672477e-05  5.924659e-05  6.159409e-05
## ASV0335     -2.971859e-38 -1.854707e-04 -1.941800e-04 -2.031592e-04
## ASV5901     -9.805845e-39 -5.565138e-05 -5.807102e-05 -6.049402e-05
## ASV0596     -1.273018e-38 -7.176431e-05 -7.496688e-05 -7.805035e-05
## ASV9271      9.664956e-39  6.875895e-05  7.242608e-05  7.618091e-05
## ASV0904      4.785330e-38  2.983666e-04  3.125018e-04  3.269509e-04
## ASV15270    -1.158588e-38 -7.740359e-05 -8.142323e-05 -8.540665e-05
## ASV0990     -1.337005e-38 -8.619886e-05 -9.029033e-05 -9.460988e-05
## ASV0155     -2.928215e-38 -1.797391e-04 -1.881538e-04 -1.967084e-04
## ASV0086     -3.913130e-40 -8.698698e-07 -9.162412e-07 -8.794055e-07
## ASV2581     -2.542304e-39 -1.112718e-05 -1.161473e-05 -1.190495e-05
## ASV1579     -3.314543e-38 -2.118830e-04 -2.219974e-04 -2.325250e-04
## ASV7730      1.141014e-53 -8.154909e-06 -8.838235e-06 -9.622499e-06
## ASV0897      1.389932e-38  8.681430e-05  9.097490e-05  9.518828e-05
## ASV1975      6.621688e-38  4.084776e-04  4.276123e-04  4.471693e-04
## ASV0759     -1.859264e-39 -9.827593e-06 -1.028934e-05 -1.068082e-05
## ASV3082     -3.988679e-38 -2.478917e-04 -2.595229e-04 -2.714834e-04
## ASV3195     -6.872618e-38 -4.324226e-04 -4.528125e-04 -4.739547e-04
## ASV0427      3.594451e-38  2.268645e-04  2.376343e-04  2.487622e-04
## ASV2674      7.922651e-39  4.704968e-05  4.924716e-05  5.139118e-05
## ASV1500      1.145959e-38  7.074228e-05  7.375281e-05  7.713873e-05
## ASV0102     -4.090128e-38 -2.595440e-04 -2.718991e-04 -2.847036e-04
## ASV1217     -1.111911e-38 -6.551469e-05 -6.863743e-05 -7.161538e-05
## ASV4998     -4.406020e-39 -2.726888e-05 -2.855598e-05 -2.986400e-05
## ASV2890      6.081302e-38  3.709956e-04  3.881982e-04  4.057367e-04
## ASV0672     -2.582478e-38 -1.610085e-04 -1.685837e-04 -1.763805e-04
## ASV6960     -2.210618e-38 -1.451870e-04 -1.524451e-04 -1.598258e-04
## ASV0821      3.996265e-38  2.407687e-04  2.521389e-04  2.633843e-04
## ASV1995     -3.687907e-38 -2.298565e-04 -2.406833e-04 -2.518063e-04
## ASV0211     -1.964535e-38 -1.291309e-04 -1.353524e-04 -1.419396e-04
## ASV0364      2.143964e-38  1.342848e-04  1.405344e-04  1.470656e-04
## ASV3616      4.872433e-38  2.884392e-04  3.017950e-04  3.149867e-04
## ASV1996      5.286083e-38  3.255493e-04  3.406247e-04  3.561859e-04
## ASV1881     -8.359372e-39 -5.277218e-05 -5.530003e-05 -5.789143e-05
## ASV1089      5.144287e-38  3.171041e-04  3.320706e-04  3.472371e-04
## ASV1450     -1.084267e-38 -6.514095e-05 -6.822333e-05 -7.125151e-05
## ASV4643     -2.945056e-38 -1.812655e-04 -1.896623e-04 -1.983074e-04
## ASV3458      1.397648e-38  8.869901e-05  9.345164e-05  9.781187e-05
## ASV2543     -1.230170e-38 -7.932820e-05 -8.312448e-05 -8.710170e-05
## ASV3306     -1.413873e-38 -8.964464e-05 -9.443131e-05 -9.883433e-05
## ASV0218     -2.834117e-38 -1.766800e-04 -1.849562e-04 -1.935124e-04
## ASV3727      1.812312e-38  1.180776e-04  1.237889e-04  1.297695e-04
## ASV4394     -1.988477e-38 -1.275681e-04 -1.336507e-04 -1.400068e-04
## ASV2636     -6.278898e-41  9.435448e-06  1.016854e-05  1.114030e-05
## ASV5116      5.329684e-39  3.207555e-05  3.345365e-05  3.493960e-05
## ASV1394     -5.050616e-38 -3.144608e-04 -3.292468e-04 -3.444505e-04
## ASV0656     -5.034807e-38 -3.087319e-04 -3.230980e-04 -3.377737e-04
## ASV0475      7.493342e-38  4.686907e-04  4.907821e-04  5.135501e-04
## ASV1042      1.880650e-38  1.170809e-04  1.225615e-04  1.282147e-04
## ASV1199     -3.841110e-38 -2.418514e-04 -2.532173e-04 -2.650490e-04
## ASV12962    -2.846091e-39 -1.629290e-05 -1.698912e-05 -1.770156e-05
## ASV0853      3.545569e-38  2.192662e-04  2.296990e-04  2.402064e-04
## ASV5069     -5.753133e-39 -4.901481e-05 -5.189245e-05 -5.492076e-05
## ASV7825     -2.194296e-38 -1.367065e-04 -1.432635e-04 -1.498799e-04
## ASV0339      2.462269e-38  1.533382e-04  1.604879e-04  1.679017e-04
## ASV2965      2.135155e-38  1.334748e-04  1.397661e-04  1.462438e-04
## ASV2347     -2.934600e-38 -1.776150e-04 -1.858545e-04 -1.941794e-04
## ASV0541      1.162348e-38  7.754091e-05  8.122004e-05  8.522479e-05
## ASV0369      3.376901e-38  2.080349e-04  2.177112e-04  2.276479e-04
## ASV0171      1.690821e-38  1.051994e-04  1.101283e-04  1.152208e-04
## ASV2235      4.275898e-38  2.534551e-04  2.648541e-04  2.764562e-04
## ASV5809     -3.870990e-38 -2.372111e-04 -2.482279e-04 -2.594902e-04
## ASV1267      4.844768e-38  2.986127e-04  3.126118e-04  3.268836e-04
## ASV0207     -5.238866e-38 -3.216329e-04 -3.366657e-04 -3.519695e-04
## ASV3126     -6.051393e-38 -3.798356e-04 -3.977731e-04 -4.162918e-04
## ASV0183     -6.769651e-38 -4.191657e-04 -4.387559e-04 -4.588923e-04
## ASV1792      2.376564e-38  1.438487e-04  1.504710e-04  1.572035e-04
## ASV2001     -5.869279e-38 -3.693294e-04 -3.867222e-04 -4.047813e-04
## ASV5732     -5.870030e-38 -3.635224e-04 -3.805740e-04 -3.980390e-04
## ASV2857     -3.676217e-38 -2.301697e-04 -2.409710e-04 -2.521649e-04
## ASV1052     -2.755478e-38 -1.680169e-04 -1.758265e-04 -1.837809e-04
## ASV3226     -1.718414e-38 -1.069126e-04 -1.118537e-04 -1.170112e-04
## ASV3766     -6.278329e-39 -3.945034e-05 -4.132002e-05 -4.324801e-05
## ASV0982     -1.781361e-38 -1.151872e-04 -1.206768e-04 -1.264660e-04
## ASV0489      7.090036e-40 -2.052890e-06 -2.306663e-06 -2.739450e-06
## ASV3990     -6.309199e-38 -3.950771e-04 -4.136828e-04 -4.328984e-04
## ASV0433     -3.856348e-38 -2.350142e-04 -2.459192e-04 -2.570052e-04
## ASV0684     -1.561629e-38 -1.009865e-04 -1.057621e-04 -1.108444e-04
## ASV0063     -4.478383e-38 -2.777049e-04 -2.906906e-04 -3.040404e-04
## ASV1399      8.942694e-39  4.796969e-05  5.004615e-05  5.196131e-05
## ASV3093     -7.475139e-38 -4.705690e-04 -4.927970e-04 -5.158185e-04
## ASV1771      8.795778e-39  5.751478e-05  6.027644e-05  6.319696e-05
## ASV7910     -4.035016e-38 -2.383909e-04 -2.494335e-04 -2.603130e-04
## ASV3718     -5.067986e-38 -3.152380e-04 -3.301011e-04 -3.453263e-04
## ASV0039     -3.880856e-38 -2.477855e-04 -2.594758e-04 -2.717563e-04
## ASV6469     -8.338458e-38 -5.153860e-04 -5.396820e-04 -5.643990e-04
## ASV8186     -5.613175e-38 -3.489533e-04 -3.653773e-04 -3.822199e-04
## ASV1091     -5.390966e-39 -3.542876e-05 -3.710904e-05 -3.891667e-05
## ASV16930    -6.841221e-38 -4.265204e-04 -4.466409e-04 -4.672910e-04
## ASV7234     -5.131346e-38 -3.195124e-04 -3.344869e-04 -3.499293e-04
## ASV1560     -5.975621e-39 -3.830775e-05 -4.014276e-05 -4.205193e-05
## ASV2968      9.829224e-39  6.427221e-05  6.742167e-05  7.069260e-05
## ASV3824     -5.321479e-38 -3.286471e-04 -3.441036e-04 -3.598567e-04
## ASV0442     -3.260640e-38 -2.046845e-04 -2.143548e-04 -2.243371e-04
## ASV0677     -2.648929e-38 -1.567459e-04 -1.637420e-04 -1.708906e-04
## ASV4796     -3.589275e-38 -2.190138e-04 -2.291301e-04 -2.394978e-04
## ASV2206     -5.581201e-38 -3.486656e-04 -3.650319e-04 -3.819448e-04
## ASV2884      1.109874e-38  6.948577e-05  7.272135e-05  7.609651e-05
## ASV0482     -2.012834e-38 -1.265144e-04 -1.324383e-04 -1.386140e-04
## ASV1273      4.594520e-38  2.894120e-04  3.031242e-04  3.172705e-04
## ASV1910      6.965553e-39  3.891661e-05  4.054824e-05  4.219662e-05
## ASV0105      3.648005e-38  2.200631e-04  2.302765e-04  2.405491e-04
## ASV0149      3.739781e-38  2.326461e-04  2.435819e-04  2.548159e-04
## ASV5007     -5.791031e-38 -3.622472e-04 -3.793030e-04 -3.968999e-04
## ASV0757      4.985611e-38  3.127393e-04  3.274737e-04  3.427146e-04
## ASV11952    -4.245817e-38 -2.599075e-04 -2.720462e-04 -2.843750e-04
## ASV4102      3.296684e-38  2.064257e-04  2.162008e-04  2.262385e-04
## ASV1034      4.236239e-38  2.610139e-04  2.731209e-04  2.855940e-04
## ASV0753      3.121908e-38  1.935776e-04  2.027011e-04  2.120227e-04
## ASV2323      1.854846e-38  1.172369e-04  1.227267e-04  1.284798e-04
## ASV0881     -1.514337e-38 -9.169850e-05 -9.605742e-05 -1.003564e-04
## ASV3730     -3.925081e-38 -2.431407e-04 -2.545092e-04 -2.661938e-04
## ASV2685     -1.573644e-38 -9.355514e-05 -9.790698e-05 -1.022003e-04
## ASV3826     -7.386742e-39 -4.607649e-05 -4.815169e-05 -5.038190e-05
## ASV0689      2.754763e-39  2.087786e-05  2.196614e-05  2.316983e-05
## ASV4315     -5.081773e-38 -3.181240e-04 -3.330566e-04 -3.485226e-04
## ASV1239      2.647892e-38  1.548325e-04  1.617174e-04  1.686952e-04
## ASV3147     -8.147667e-39 -5.273082e-05 -5.522120e-05 -5.787259e-05
## ASV3454     -3.840625e-38 -2.376719e-04 -2.487590e-04 -2.601704e-04
## ASV4411     -2.207363e-38 -1.411304e-04 -1.478168e-04 -1.548353e-04
## ASV3007      4.665056e-38  2.846305e-04  2.978846e-04  3.113380e-04
## ASV6151     -3.826260e-38 -2.311648e-04 -2.417682e-04 -2.525848e-04
## ASV0834      3.834181e-38  2.417599e-04  2.531507e-04  2.649866e-04
## ASV1231      5.598695e-38  3.476271e-04  3.638867e-04  3.806329e-04
## ASV0643      4.726539e-38  2.931483e-04  3.068233e-04  3.209251e-04
## ASV0924      1.319149e-39  8.371462e-06  8.880343e-06  9.289912e-06
## ASV3238     -2.383924e-38 -1.450538e-04 -1.518144e-04 -1.586485e-04
## ASV1276     -2.750582e-38 -1.704933e-04 -1.783989e-04 -1.865927e-04
## ASV5503     -7.483618e-38 -4.610935e-04 -4.827858e-04 -5.048215e-04
## ASV0404      2.947214e-38  1.853304e-04  1.940365e-04  2.030864e-04
## ASV3430      2.721993e-39  2.718958e-05  2.858903e-05  3.042962e-05
## ASV5401     -3.145597e-38 -1.968745e-04 -2.060564e-04 -2.156208e-04
## ASV3426     -6.787422e-38 -4.199501e-04 -4.396863e-04 -4.598477e-04
## ASV0777      4.032554e-38  2.498649e-04  2.616390e-04  2.736540e-04
## ASV11093    -2.707956e-38 -1.680200e-04 -1.758582e-04 -1.839485e-04
## ASV2170     -2.409193e-38 -1.464803e-04 -1.533084e-04 -1.602061e-04
## ASV3861      2.234765e-38  1.331626e-04  1.392471e-04  1.453692e-04
## ASV1723     -3.913085e-38 -2.442268e-04 -2.556668e-04 -2.674976e-04
## ASV2460     -2.193632e-38 -1.381850e-04 -1.447009e-04 -1.514602e-04
## ASV1218     -3.292598e-38 -2.010199e-04 -2.103230e-04 -2.198323e-04
## ASV0436      2.946358e-39  1.331743e-05  1.384056e-05  1.422571e-05
## ASV0919      2.787107e-38  1.711740e-04  1.791669e-04  1.873197e-04
## ASV0577      1.197892e-38  7.322037e-05  7.667632e-05  8.014452e-05
## ASV2517      3.185481e-38  1.945977e-04  2.038982e-04  2.131155e-04
## ASV2628     -3.767529e-38 -2.362507e-04 -2.474003e-04 -2.588990e-04
## ASV1743     -3.405990e-38 -2.152824e-04 -2.255242e-04 -2.361009e-04
## ASV1678     -2.915553e-38 -1.856303e-04 -1.944034e-04 -2.035897e-04
## ASV0315      3.877318e-38  2.423240e-04  2.536752e-04  2.654343e-04
## ASV0253      1.830957e-38  1.129617e-04  1.183950e-04  1.238022e-04
## ASV1363      5.068679e-38  3.074871e-04  3.216947e-04  3.361258e-04
## ASV0995     -2.700195e-38 -1.686858e-04 -1.767244e-04 -1.849155e-04
## ASV4185     -1.260804e-38 -7.434328e-05 -7.777642e-05 -8.116074e-05
## ASV0782      2.405638e-38  1.534533e-04  1.607146e-04  1.683273e-04
## ASV3240     -2.904426e-38 -1.828621e-04 -1.914709e-04 -2.004176e-04
## ASV1392     -5.284547e-38 -3.318758e-04 -3.474738e-04 -3.636646e-04
## ASV8488     -1.200352e-38 -7.552078e-05 -7.899822e-05 -8.269069e-05
## ASV2814     -1.966965e-38 -1.231474e-04 -1.288803e-04 -1.348705e-04
## ASV0678     -3.908943e-38 -2.500311e-04 -2.619015e-04 -2.743377e-04
## ASV1295     -2.810054e-38 -1.754134e-04 -1.836099e-04 -1.921113e-04
## ASV7517     -1.780714e-38 -1.069464e-04 -1.119299e-04 -1.168989e-04
## ASV2996     -5.539339e-38 -3.421372e-04 -3.581900e-04 -3.745838e-04
## ASV2882     -5.239294e-38 -3.218551e-04 -3.367257e-04 -3.520480e-04
## ASV1317      3.154422e-38  1.976127e-04  2.069531e-04  2.165638e-04
## ASV9106     -5.235592e-38 -3.267484e-04 -3.420324e-04 -3.578601e-04
## ASV9688     -4.984323e-38 -3.108603e-04 -3.255079e-04 -3.405609e-04
## ASV6181     -4.990943e-38 -3.103362e-04 -3.249440e-04 -3.399245e-04
## ASV2936      1.175422e-39  9.038250e-06  9.512259e-06  1.003781e-05
## ASV0192     -2.128297e-38 -1.287285e-04 -1.344717e-04 -1.404788e-04
## ASV2509     -2.437611e-38 -1.562138e-04 -1.636759e-04 -1.714556e-04
## ASV0863      8.953436e-38  5.448168e-04  5.698605e-04  5.955230e-04
## ASV2762     -2.235036e-38 -1.396823e-04 -1.461929e-04 -1.529726e-04
## ASV4904     -4.781267e-38 -2.973558e-04 -3.113240e-04 -3.256787e-04
## ASV0571      1.671071e-38  1.015318e-04  1.065295e-04  1.113326e-04
## ASV13304    -6.609676e-39 -4.687697e-05 -4.918116e-05 -5.174039e-05
## ASV6863     -1.080011e-38 -6.750041e-05 -7.059813e-05 -7.387617e-05
## ASV4844      3.044650e-39  2.429113e-05  2.560657e-05  2.706548e-05
## ASV10779    -5.275301e-38 -3.265425e-04 -3.419023e-04 -3.575886e-04
## ASV7921     -4.416407e-38 -2.754550e-04 -2.883808e-04 -3.017197e-04
## ASV8458     -4.685252e-38 -2.878524e-04 -3.012329e-04 -3.149376e-04
## ASV2593     -7.190342e-39 -3.940412e-05 -4.114415e-05 -4.276659e-05
## ASV4410     -2.491929e-38 -1.561646e-04 -1.634415e-04 -1.710356e-04
## ASV0593      6.302221e-38  3.999655e-04  4.191121e-04  4.388331e-04
## ASV2669      3.842773e-38  2.344708e-04  2.452955e-04  2.563668e-04
## ASV0868     -4.923435e-38 -3.069522e-04 -3.213245e-04 -3.361777e-04
## ASV3123     -1.659969e-38 -1.074707e-04 -1.129689e-04 -1.183751e-04
## ASV3482     -2.027781e-38 -1.251315e-04 -1.309367e-04 -1.369208e-04
## ASV2552     -5.761207e-38 -3.463159e-04 -3.625599e-04 -3.786735e-04
## ASV0723      6.548178e-38  3.944410e-04  4.127884e-04  4.311765e-04
## ASV0526     -4.197203e-38 -2.611904e-04 -2.734074e-04 -2.860314e-04
## ASV4623     -1.871415e-38 -1.179297e-04 -1.234084e-04 -1.291751e-04
## ASV2070     -5.862263e-38 -3.641165e-04 -3.812087e-04 -3.987617e-04
## ASV1198      1.631923e-39  9.455039e-06  9.760426e-06  1.017174e-05
## ASV3034      2.758890e-39  1.560572e-05  1.603176e-05  1.669333e-05
## ASV1208     -7.021706e-39 -4.319985e-05 -4.525738e-05 -4.732411e-05
## ASV4860      9.235201e-39  5.882940e-05  6.170565e-05  6.461853e-05
## ASV2493     -1.811249e-38 -1.127878e-04 -1.180263e-04 -1.234776e-04
## ASV4217     -1.316017e-38 -7.808744e-05 -8.164926e-05 -8.521696e-05
## ASV1516     -6.710125e-39 -4.869653e-05 -5.115361e-05 -5.387270e-05
## ASV1186      2.158371e-38  1.347539e-04  1.409211e-04  1.474434e-04
## ASV1906     -1.864510e-38 -1.169099e-04 -1.225372e-04 -1.282402e-04
## ASV8220     -2.423491e-39 -1.816533e-05 -1.905412e-05 -2.009312e-05
## ASV4227     -4.296795e-38 -2.670673e-04 -2.795664e-04 -2.924491e-04
## ASV1013      2.595926e-38  1.671806e-04  1.751018e-04  1.834620e-04
## ASV7952     -2.810362e-38 -1.805732e-04 -1.892784e-04 -1.983045e-04
## ASV5923     -3.272647e-38 -2.059624e-04 -2.156447e-04 -2.257127e-04
## ASV0190     -4.176537e-38 -2.561965e-04 -2.681210e-04 -2.802966e-04
## ASV0491     -3.912354e-39 -2.771884e-05 -2.914572e-05 -3.066382e-05
## ASV9535     -1.764986e-38 -1.101035e-04 -1.152035e-04 -1.205276e-04
## ASV9947     -1.220474e-38 -8.190197e-05 -8.593190e-05 -9.020400e-05
## ASV6518     -1.156573e-38 -7.191753e-05 -7.531328e-05 -7.878825e-05
## ASV1741     -1.157422e-38 -7.371356e-05 -7.733438e-05 -8.099079e-05
## ASV1874      2.310758e-38  1.395646e-04  1.460938e-04  1.526138e-04
## ASV2150      6.286211e-39  3.949764e-05  4.140886e-05  4.333946e-05
## ASV5262     -1.199800e-38 -7.337375e-05 -7.676745e-05 -8.024382e-05
## ASV1729     -4.209242e-38 -2.638695e-04 -2.762569e-04 -2.891024e-04
## ASV1522     -7.010623e-39 -5.037918e-05 -5.305546e-05 -5.582639e-05
## ASV3250      9.367271e-39  5.663359e-05  5.919321e-05  6.183842e-05
## ASV4338     -4.281358e-38 -2.666399e-04 -2.791796e-04 -2.920727e-04
## ASV1386      5.091251e-38  3.183220e-04  3.332605e-04  3.487130e-04
## ASV0694     -5.280541e-39 -3.586574e-05 -3.751013e-05 -3.939614e-05
## ASV2026      3.751767e-39  2.822736e-05  2.966371e-05  3.128098e-05
## ASV0191     -3.483525e-38 -2.125785e-04 -2.224075e-04 -2.324476e-04
## ASV1641      1.607065e-38  1.029067e-04  1.079211e-04  1.130391e-04
## ASV1326      8.301652e-38  5.161503e-04  5.404710e-04  5.653833e-04
## ASV4786     -2.230045e-39 -1.536227e-05 -1.609469e-05 -1.691458e-05
## ASV0342      2.034193e-38  1.294865e-04  1.356055e-04  1.420108e-04
## ASV3025     -2.472267e-38 -1.504286e-04 -1.573835e-04 -1.644718e-04
## ASV6533     -4.202969e-38 -2.577286e-04 -2.696907e-04 -2.819370e-04
## ASV1898      4.594799e-38  2.880715e-04  3.016529e-04  3.156658e-04
## ASV1940      2.619137e-38  1.633855e-04  1.711288e-04  1.790393e-04
## ASV4968     -4.764662e-38 -2.983921e-04 -3.123486e-04 -3.268560e-04
## ASV3401     -2.516869e-38 -1.565666e-04 -1.638269e-04 -1.713816e-04
## ASV3211      1.451760e-38  9.371642e-05  9.819609e-05  1.028949e-04
## ASV1489     -6.682710e-38 -4.147101e-04 -4.341770e-04 -4.541449e-04
## ASV4139     -3.900016e-38 -2.430900e-04 -2.544670e-04 -2.662271e-04
## ASV6059     -4.113916e-38 -2.565738e-04 -2.685526e-04 -2.809724e-04
## ASV0918      1.093360e-38  6.510880e-05  6.808357e-05  7.107512e-05
## ASV1449      4.000056e-38  2.492890e-04  2.609644e-04  2.730240e-04
## ASV5652     -2.754336e-38 -1.712626e-04 -1.793864e-04 -1.876569e-04
## ASV4091     -1.943147e-39 -5.982020e-06 -6.134610e-06 -6.105732e-06
## ASV7638     -2.594639e-38 -1.593331e-04 -1.667115e-04 -1.742920e-04
## ASV6525     -3.706829e-38 -2.246156e-04 -2.349504e-04 -2.454935e-04
## ASV8959     -3.700607e-38 -2.315707e-04 -2.424571e-04 -2.537102e-04
## ASV0699      2.844740e-38  1.770863e-04  1.853707e-04  1.939122e-04
## ASV2925      3.452354e-38  2.169426e-04  2.271776e-04  2.377671e-04
## ASV0618      7.219910e-39  4.766619e-05  5.002519e-05  5.246478e-05
## ASV2083      5.018464e-39  3.326083e-05  3.494484e-05  3.666150e-05
## ASV6192     -4.556983e-38 -2.824383e-04 -2.956792e-04 -3.092613e-04
## ASV8640     -5.148762e-38 -3.193229e-04 -3.342709e-04 -3.496390e-04
## ASV1103      2.149890e-38  1.312781e-04  1.373343e-04  1.435463e-04
## ASV4240     -3.353191e-39 -1.598031e-05 -1.667639e-05 -1.720160e-05
## ASV2180      1.344607e-38  8.312271e-05  8.702725e-05  9.101621e-05
## ASV9157     -3.307252e-38 -2.047624e-04 -2.143102e-04 -2.241405e-04
## ASV1307      6.415343e-38  4.015145e-04  4.204117e-04  4.399265e-04
## ASV4960     -1.653270e-38 -1.004238e-04 -1.050491e-04 -1.097706e-04
## ASV3930     -1.406616e-38 -8.547606e-05 -8.941937e-05 -9.344439e-05
## ASV1200     -2.800829e-38 -1.756356e-04 -1.839455e-04 -1.924998e-04
## ASV4676     -1.441961e-38 -8.937840e-05 -9.356162e-05 -9.786067e-05
## ASV6993     -5.412234e-38 -3.323963e-04 -3.479324e-04 -3.637570e-04
## ASV4813     -2.092107e-38 -1.300788e-04 -1.360722e-04 -1.423402e-04
## ASV4364     -6.964206e-38 -4.286380e-04 -4.486678e-04 -4.691250e-04
## ASV0141      2.896778e-38  1.710394e-04  1.787975e-04  1.865853e-04
## ASV3509      1.642973e-38  1.071823e-04  1.124009e-04  1.178456e-04
## ASV2751      2.889865e-38  1.806039e-04  1.890864e-04  1.978511e-04
## ASV4913     -2.998635e-38 -1.852427e-04 -1.939084e-04 -2.027879e-04
## ASV0138      7.386171e-38  4.585610e-04  4.801881e-04  5.022958e-04
## ASV7697     -2.129214e-38 -1.292620e-04 -1.352235e-04 -1.412958e-04
## ASV1602      1.158982e-38  6.661215e-05  6.955973e-05  7.248385e-05
## ASV5976     -4.147301e-38 -2.570973e-04 -2.691043e-04 -2.814711e-04
## ASV7525     -4.279911e-38 -2.648960e-04 -2.772436e-04 -2.899620e-04
## ASV4961      1.936969e-38  1.196536e-04  1.253111e-04  1.310421e-04
## ASV2546      5.361939e-38  3.241216e-04  3.387858e-04  3.539327e-04
## ASV0721     -3.147587e-38 -1.951476e-04 -2.042741e-04 -2.136571e-04
## ASV0542      2.899991e-38  1.792970e-04  1.877279e-04  1.963337e-04
## ASV3865      1.882864e-38  1.149462e-04  1.202859e-04  1.257228e-04
## ASV5571     -3.451819e-38 -2.084702e-04 -2.181820e-04 -2.279241e-04
## ASV6804      3.511144e-39  2.552975e-05  2.682779e-05  2.825637e-05
## ASV4424      3.083974e-38  1.925458e-04  2.016097e-04  2.109376e-04
## ASV3395      2.417530e-38  1.424861e-04  1.488028e-04  1.552699e-04
## ASV2394     -3.040027e-38 -1.898807e-04 -1.987894e-04 -2.079978e-04
## ASV8629     -3.040027e-38 -1.898807e-04 -1.987743e-04 -2.079815e-04
## ASV1018      2.761158e-38  1.720351e-04  1.800355e-04  1.883524e-04
## ASV6139     -6.188109e-38 -3.849586e-04 -4.030683e-04 -4.216570e-04
## ASV10411    -3.161734e-38 -1.973956e-04 -2.066776e-04 -2.162479e-04
## ASV3992     -1.211140e-38 -7.672443e-05 -8.024430e-05 -8.401607e-05
## ASV7131     -2.355819e-39 -1.522148e-05 -1.582255e-05 -1.658133e-05
## ASV3729     -5.786726e-39 -3.274450e-05 -3.417555e-05 -3.558091e-05
## ASV2197     -6.990443e-39 -4.260302e-05 -4.452078e-05 -4.653001e-05
## ASV2426     -3.245921e-38 -1.987067e-04 -2.080004e-04 -2.174311e-04
## ASV3669     -2.919456e-38 -1.853044e-04 -1.940308e-04 -2.031719e-04
## ASV1820      1.591961e-38  9.797021e-05  1.025977e-04  1.072723e-04
## ASV7081     -2.810923e-38 -1.757156e-04 -1.839592e-04 -1.924906e-04
## ASV7872     -3.626603e-38 -2.237161e-04 -2.341177e-04 -2.448172e-04
## ASV1670     -4.820870e-39 -2.732090e-05 -2.849741e-05 -2.967204e-05
## ASV0712      3.344421e-38  2.153280e-04  2.256899e-04  2.364706e-04
## ASV0474      5.580430e-38  3.337950e-04  3.489150e-04  3.643422e-04
## ASV1196      5.269687e-38  3.289256e-04  3.442857e-04  3.602194e-04
## ASV0845      3.361745e-38  2.070936e-04  2.167379e-04  2.266392e-04
## ASV12393    -6.720861e-38 -4.192578e-04 -4.389982e-04 -4.593027e-04
## ASV5867     -2.570070e-38 -1.612027e-04 -1.688450e-04 -1.766980e-04
## ASV17619    -9.217831e-39 -6.059511e-05 -6.349302e-05 -6.659138e-05
## ASV4686     -2.262238e-38 -1.423333e-04 -1.490498e-04 -1.560102e-04
## ASV3520     -3.734315e-38 -2.321342e-04 -2.430046e-04 -2.542051e-04
## ASV10800    -6.063568e-38 -3.791161e-04 -3.969914e-04 -4.154011e-04
## ASV2706      5.356144e-38  3.362639e-04  3.520958e-04  3.684879e-04
## ASV1227     -7.836011e-39 -4.718554e-05 -4.938342e-05 -5.158206e-05
## ASV2621      4.856918e-38  3.082861e-04  3.229571e-04  3.381698e-04
## ASV0460      1.058262e-38  6.867972e-05  7.198703e-05  7.545256e-05
## ASV1069     -4.013579e-38 -2.524820e-04 -2.643826e-04 -2.767205e-04
## ASV6939     -3.781526e-38 -2.335146e-04 -2.444155e-04 -2.555993e-04
## ASV2862     -5.219391e-38 -3.242030e-04 -3.394497e-04 -3.550807e-04
## ASV1021     -3.120917e-38 -1.904943e-04 -1.994085e-04 -2.084198e-04
## ASV3845      2.398763e-38  1.504767e-04  1.575699e-04  1.648957e-04
## ASV0732      2.066603e-38  1.316825e-04  1.378914e-04  1.444111e-04
## ASV10731     1.656501e-38  1.018929e-04  1.066852e-04  1.115452e-04
## ASV3378      2.039950e-38  1.221437e-04  1.276924e-04  1.333376e-04
## ASV7154      2.327404e-39  1.023274e-05  1.065491e-05  1.092536e-05
## ASV9876      8.781653e-39  5.634575e-05  5.905129e-05  6.186114e-05
## ASV0631      4.002639e-38  2.533981e-04  2.653662e-04  2.778343e-04
## ASV13027    -3.040027e-38 -1.917868e-04 -2.007892e-04 -2.101882e-04
## ASV2497     -3.040027e-38 -1.917868e-04 -2.007739e-04 -2.101715e-04
## ASV3966     -4.276501e-38 -2.703421e-04 -2.830596e-04 -2.963365e-04
## ASV2574      2.681653e-38  1.619625e-04  1.695227e-04  1.770925e-04
## ASV0545     -2.358888e-38 -1.499638e-04 -1.570812e-04 -1.644811e-04
## ASV8453     -2.701459e-38 -1.702492e-04 -1.782500e-04 -1.865864e-04
## ASV0221     -1.436321e-38 -9.007618e-05 -9.431342e-05 -9.869976e-05
## ASV3305      1.903450e-38  1.213072e-04  1.271975e-04  1.332174e-04
## ASV2647     -1.382212e-38 -8.420160e-05 -8.807563e-05 -9.204488e-05
## ASV5789     -6.140388e-38 -3.880660e-04 -4.063723e-04 -4.254316e-04
## ASV1731     -2.088928e-38 -1.236289e-04 -1.293682e-04 -1.350188e-04
## ASV3857      8.970316e-39  5.463725e-05  5.716708e-05  5.974511e-05
## ASV0405      3.776918e-38  2.296122e-04  2.402861e-04  2.510931e-04
## ASV0094     -4.463495e-38 -2.639514e-04 -2.757301e-04 -2.877802e-04
## ASV0158     -2.203770e-39 -9.960242e-06 -1.029840e-05 -1.059245e-05
## ASV5507     -3.683166e-38 -2.293418e-04 -2.400269e-04 -2.511083e-04
## ASV1023     -1.262033e-39 -2.657244e-06 -2.657473e-06 -2.508781e-06
## ASV0488     -2.385343e-38 -1.490640e-04 -1.560438e-04 -1.632731e-04
## ASV1459      2.088266e-38  1.258465e-04  1.315737e-04  1.374414e-04
## ASV4349     -6.567031e-39 -3.795884e-05 -3.972643e-05 -4.141334e-05
## ASV1172      6.265962e-38  3.870047e-04  4.050819e-04  4.236188e-04
## ASV10187    -1.584248e-38 -1.012312e-04 -1.059901e-04 -1.110174e-04
## ASV7227      9.469253e-39  5.983662e-05  6.277531e-05  6.572220e-05
## ASV10340     9.107694e-39  5.857218e-05  6.144260e-05  6.437918e-05
## ASV10821    -1.761531e-38 -1.096192e-04 -1.146606e-04 -1.199467e-04
## ASV13810    -1.761531e-38 -1.096192e-04 -1.146521e-04 -1.199373e-04
## ASV3230     -1.410410e-38 -8.802138e-05 -9.204916e-05 -9.630440e-05
## ASV5524      1.733267e-39  9.224622e-06  9.757601e-06  1.013115e-05
## ASV8742     -1.761531e-38 -1.096192e-04 -1.146375e-04 -1.199210e-04
## ASV9188      3.992908e-38  2.424561e-04  2.537867e-04  2.651873e-04
## ASV4658      1.966638e-38  1.224225e-04  1.282782e-04  1.341991e-04
## ASV7889      2.499059e-38  1.499814e-04  1.568040e-04  1.637648e-04
## ASV1466      4.679535e-39  3.395611e-05  3.581877e-05  3.772160e-05
## ASV1424     -1.295084e-38 -7.166497e-05 -7.482777e-05 -7.782212e-05
## ASV0098     -2.976340e-38 -1.881115e-04 -1.970667e-04 -2.063001e-04
## ASV0067     -4.840102e-38 -3.014637e-04 -3.155641e-04 -3.301321e-04
## ASV9434     -2.022495e-38 -1.251776e-04 -1.311026e-04 -1.371173e-04
## ASV3270     -7.643380e-39 -4.919917e-05 -5.160656e-05 -5.406884e-05
## ASV4518     -3.490079e-38 -2.147222e-04 -2.247436e-04 -2.349854e-04
## ASV7661     -3.338061e-38 -2.023259e-04 -2.117491e-04 -2.212434e-04
## ASV4223      3.588748e-39  2.293499e-05  2.406129e-05  2.519858e-05
## ASV3481      2.611052e-38  1.709968e-04  1.792399e-04  1.879513e-04
## ASV7819     -5.088070e-38 -3.165658e-04 -3.314256e-04 -3.467171e-04
## ASV3095     -2.357105e-39 -1.371502e-05 -1.427221e-05 -1.487753e-05
## ASV4476     -1.013193e-38 -6.484205e-05 -6.787450e-05 -7.109885e-05
## ASV1713      3.181440e-38  1.916884e-04  2.005754e-04  2.095131e-04
## ASV11165    -8.468706e-39 -5.027694e-05 -5.252023e-05 -5.481483e-05
## ASV2179      6.285935e-38  3.920582e-04  4.105072e-04  4.294918e-04
## ASV3747      5.393274e-38  3.361877e-04  3.519593e-04  3.682225e-04
## ASV1410      3.553342e-39  1.856253e-05  1.932571e-05  2.003600e-05
## ASV6069     -3.385004e-38 -2.112077e-04 -2.210691e-04 -2.312968e-04
## ASV1939      8.979039e-39  5.826510e-05  6.108210e-05  6.402371e-05
## ASV7865     -5.284404e-38 -3.291990e-04 -3.446387e-04 -3.605537e-04
## ASV4488     -4.805763e-38 -3.021753e-04 -3.164111e-04 -3.311706e-04
## ASV0938      3.858265e-38  2.393716e-04  2.505557e-04  2.620782e-04
## ASV7852     -2.967785e-38 -1.819876e-04 -1.904824e-04 -1.991366e-04
## ASV2503     -2.209837e-39 -1.659019e-05 -1.740378e-05 -1.836021e-05
## ASV2993     -4.122813e-38 -2.588427e-04 -2.710070e-04 -2.836270e-04
## ASV3752     -5.274548e-39 -3.211412e-05 -3.356478e-05 -3.507738e-05
## ASV2557     -4.191849e-38 -2.635474e-04 -2.760664e-04 -2.889319e-04
## ASV6522     -9.007829e-39 -5.477398e-05 -5.730506e-05 -5.988232e-05
## ASV0088     -3.308933e-38 -1.972935e-04 -2.064256e-04 -2.155125e-04
## ASV7935     -2.642181e-38 -1.635758e-04 -1.712604e-04 -1.791202e-04
## ASV0942     -3.308049e-38 -2.079737e-04 -2.176955e-04 -2.278437e-04
## ASV7709     -4.010930e-38 -2.444468e-04 -2.558572e-04 -2.673999e-04
## ASV4588     -2.096652e-38 -1.253618e-04 -1.313071e-04 -1.371097e-04
## ASV5765     -5.601122e-38 -3.476535e-04 -3.639446e-04 -3.806882e-04
## ASV3562     -3.471049e-39 -1.834182e-05 -1.906265e-05 -1.977156e-05
## ASV9076     -4.259211e-38 -2.656545e-04 -2.780984e-04 -2.909613e-04
## ASV4707     -4.738833e-38 -2.962376e-04 -3.101912e-04 -3.245725e-04
## ASV2188      3.330284e-38  2.105652e-04  2.205422e-04  2.308899e-04
## ASV0613      5.627959e-39  3.884251e-05  4.064057e-05  4.270089e-05
## ASV0663     -2.128331e-38 -1.334838e-04 -1.397481e-04 -1.462489e-04
## ASV3361     -4.484393e-38 -2.666744e-04 -2.790375e-04 -2.912924e-04
## ASV1478      4.786493e-38  2.947571e-04  3.085124e-04  3.225855e-04
## ASV0213      2.649891e-38  1.636410e-04  1.713268e-04  1.791670e-04
## ASV7674     -1.468918e-38 -8.974063e-05 -9.387951e-05 -9.812733e-05
## ASV2137     -1.584706e-38 -9.625833e-05 -1.007163e-04 -1.052428e-04
## ASV8246     -1.303075e-38 -8.003929e-05 -8.377837e-05 -8.759305e-05
## ASV0047     -4.150135e-38 -2.538915e-04 -2.657137e-04 -2.777503e-04
## ASV6117      1.039659e-39  8.341143e-06  8.819576e-06  9.319976e-06
## ASV3349     -7.756286e-39 -4.842211e-05 -5.066403e-05 -5.300838e-05
## ASV10881    -2.662156e-38 -1.659203e-04 -1.736899e-04 -1.817129e-04
## ASV6979     -1.776051e-38 -1.119416e-04 -1.172010e-04 -1.226806e-04
## ASV7930     -3.502775e-38 -2.171707e-04 -2.272508e-04 -2.376924e-04
## ASV7322      1.160320e-38  7.268315e-05  7.618500e-05  7.972419e-05
## ASV4927     -5.597831e-39 -3.659796e-05 -3.829264e-05 -4.014876e-05
## ASV9054     -1.974473e-38 -1.213696e-04 -1.270452e-04 -1.328343e-04
## ASV2692     -1.415235e-38 -9.325971e-05 -9.787176e-05 -1.026270e-04
## ASV1666     -1.128303e-38 -6.512005e-05 -6.800987e-05 -7.088612e-05
## ASV4728      2.296259e-38  1.398116e-04  1.461468e-04  1.527348e-04
## ASV3097      1.455704e-38  9.256484e-05  9.695195e-05  1.015279e-04
## ASV4962     -1.109023e-38 -7.394556e-05 -7.757354e-05 -8.140323e-05
## ASV5057      1.774724e-38  1.134256e-04  1.188213e-04  1.244590e-04
## ASV2639      3.221944e-38  2.052521e-04  2.150166e-04  2.251795e-04
## ASV1808     -2.684481e-39 -2.363903e-05 -2.503301e-05 -2.653633e-05
## ASV6333     -5.520018e-39 -3.834703e-05 -4.022320e-05 -4.228480e-05
## ASV4328     -1.484326e-38 -9.219545e-05 -9.651742e-05 -1.009611e-04
## ASV7707     -4.416514e-38 -2.716547e-04 -2.844220e-04 -2.973783e-04
## ASV11022    -4.299931e-38 -2.637218e-04 -2.760366e-04 -2.885750e-04
## ASV1469     -8.052818e-39 -4.942537e-05 -5.161795e-05 -5.396413e-05
## ASV3919     -1.414495e-38 -9.051565e-05 -9.480915e-05 -9.930821e-05
## ASV4038     -2.976963e-38 -1.842646e-04 -1.929572e-04 -2.018117e-04
## ASV4048      9.918914e-39  6.539359e-05  6.858578e-05  7.193452e-05
## ASV0634      1.196956e-38  7.595324e-05  7.953748e-05  8.328684e-05
## ASV1852     -3.229859e-38 -2.067775e-04 -2.166479e-04 -2.269402e-04
## ASV2505      2.518163e-38  1.561750e-04  1.634463e-04  1.709628e-04
## ASV1762     -3.875928e-38 -2.398112e-04 -2.509575e-04 -2.624645e-04
## ASV3761     -3.280191e-38 -2.034671e-04 -2.129224e-04 -2.227104e-04
## ASV0775     -5.573295e-38 -3.450361e-04 -3.611855e-04 -3.777554e-04
## ASV10911    -4.097607e-38 -2.531088e-04 -2.649103e-04 -2.770376e-04
## ASV1339     -7.150682e-39 -4.325532e-05 -4.515354e-05 -4.716675e-05
## ASV5214     -9.525510e-39 -5.784683e-05 -6.046549e-05 -6.317816e-05
## ASV4945      1.063081e-38  6.677125e-05  6.995175e-05  7.320830e-05
## ASV5624     -9.451872e-39 -5.504897e-05 -5.749199e-05 -5.994980e-05
## ASV3429     -5.411225e-39 -3.129353e-05 -3.280992e-05 -3.420863e-05
## ASV8416     -3.964180e-39 -2.866923e-05 -3.015641e-05 -3.175097e-05
## ASV2400     -5.014752e-38 -3.120316e-04 -3.265810e-04 -3.416430e-04
## ASV3388     -1.585134e-38 -1.014405e-04 -1.062274e-04 -1.112690e-04
## ASV7089      1.078438e-38  6.386509e-05  6.675945e-05  6.966978e-05
## ASV3396     -1.706649e-38 -1.041804e-04 -1.090397e-04 -1.139607e-04
## ASV0343      2.253455e-38  1.477895e-04  1.549308e-04  1.624655e-04
## ASV5505     -3.002117e-38 -1.888784e-04 -1.977438e-04 -2.069745e-04
## ASV6721     -1.388994e-38 -8.897990e-05 -9.315621e-05 -9.758549e-05
## ASV0537      1.083073e-38  7.668687e-05  8.060197e-05  8.479140e-05
## ASV7753     -3.924621e-38 -2.452021e-04 -2.566482e-04 -2.685380e-04
## ASV5022     -2.426241e-39 -1.928400e-05 -2.032874e-05 -2.147642e-05
## ASV1073      5.477660e-38  3.424264e-04  3.585078e-04  3.751265e-04
## ASV1347     -1.843176e-53 -7.378587e-07 -7.505202e-07 -8.295470e-07
## ASV15032     1.716686e-38  1.038526e-04  1.086769e-04  1.135331e-04
## ASV18213    -1.843176e-53 -7.378641e-07 -7.572392e-07 -8.365261e-07
## ASV20691     1.380943e-38  8.745635e-05  9.163427e-05  9.593565e-05
## ASV4260     -7.189165e-39 -4.502563e-05 -4.712375e-05 -4.931895e-05
## ASV4923      1.201268e-38  7.597138e-05  7.959908e-05  8.332917e-05
## ASV7995     -1.843176e-53 -7.378612e-07 -7.656641e-07 -8.454530e-07
## ASV8960      2.476201e-38  1.535265e-04  1.607482e-04  1.681293e-04
## ASV10682     1.973690e-38  1.171999e-04  1.225136e-04  1.278740e-04
## ASV11911    -1.843176e-53 -7.378788e-07 -7.817363e-07 -8.625030e-07
## ASV14296     3.029779e-38  1.849851e-04  1.935955e-04  2.023389e-04
## ASV2314      1.571118e-38  1.049800e-04  1.101566e-04  1.156044e-04
## ASV3819      1.953065e-38  1.194147e-04  1.249598e-04  1.306079e-04
## ASV4517     -8.601489e-53 -7.378795e-07 -8.057896e-07 -8.883055e-07
## ASV8941      3.624761e-38  2.277662e-04  2.384662e-04  2.495778e-04
## ASV1444      8.601489e-53  7.378818e-07  8.170046e-07  9.005041e-07
## ASV5959      6.784199e-39  4.167676e-05  4.359344e-05  4.556887e-05
## ASV3623     -1.724633e-38 -1.055589e-04 -1.103678e-04 -1.153716e-04
## ASV0260      2.024028e-38  1.269794e-04  1.329433e-04  1.391305e-04
## ASV4401     -1.204246e-38 -8.304616e-05 -8.737652e-05 -9.178812e-05
## ASV2891     -4.408109e-38 -2.770481e-04 -2.900933e-04 -3.036208e-04
## ASV2778     -9.969306e-39 -6.236515e-05 -6.529702e-05 -6.832813e-05
## ASV8744      2.051786e-38  1.227527e-04  1.282949e-04  1.339719e-04
## ASV1079      4.153702e-38  2.518380e-04  2.632976e-04  2.751136e-04
## ASV19688     2.500328e-39  1.859260e-05  1.959729e-05  2.065919e-05
## ASV4039      4.355508e-39  3.075374e-05  3.236437e-05  3.404862e-05
## ASV4982     -3.040027e-38 -1.885135e-04 -1.972423e-04 -2.063063e-04
## ASV1071     -3.040027e-38 -1.885135e-04 -1.972276e-04 -2.062902e-04
## ASV7666     -3.040027e-38 -1.885135e-04 -1.972128e-04 -2.062741e-04
## ASV0502      4.220335e-38  2.635080e-04  2.758206e-04  2.885891e-04
## ASV3624     -3.040027e-38 -1.887821e-04 -1.974954e-04 -2.065817e-04
## ASV0403      4.682997e-39  2.715393e-05  2.824295e-05  2.944286e-05
## ASV4939     -3.040027e-38 -1.887821e-04 -1.974791e-04 -2.065638e-04
## ASV6297     -3.605016e-38 -2.258223e-04 -2.364340e-04 -2.474168e-04
## ASV6343      3.400843e-38  2.022040e-04  2.113099e-04  2.205898e-04
## ASV0954     -7.556871e-39 -4.281063e-05 -4.472364e-05 -4.656755e-05
## ASV10225    -1.281403e-38 -8.198314e-05 -8.596990e-05 -9.004248e-05
## ASV1584      5.284594e-38  3.280657e-04  3.433894e-04  3.591889e-04
## ASV1803      2.011038e-38  1.208411e-04  1.263472e-04  1.319497e-04
## ASV2576     -5.284594e-38 -3.280657e-04 -3.433562e-04 -3.591531e-04
## ASV3252      3.409593e-38  2.131847e-04  2.232321e-04  2.335818e-04
## ASV3463     -5.284594e-38 -3.280657e-04 -3.433290e-04 -3.591236e-04
## ASV3822     -3.957697e-38 -2.491155e-04 -2.608625e-04 -2.730481e-04
## ASV4926     -2.238915e-38 -1.330036e-04 -1.391014e-04 -1.451965e-04
## ASV5564     -1.365277e-38 -8.479790e-05 -8.874238e-05 -9.282992e-05
## ASV5595     -8.015824e-39 -4.952602e-05 -5.181020e-05 -5.418404e-05
## ASV16463    -3.040027e-38 -1.909549e-04 -1.999117e-04 -2.092282e-04
## ASV6277      2.997969e-38  1.905645e-04  1.996316e-04  2.090419e-04
## ASV1344      3.040027e-38  1.909549e-04  1.999046e-04  2.092204e-04
## ASV1869      2.027390e-38  1.221720e-04  1.278721e-04  1.335651e-04
## ASV8155     -1.751049e-38 -1.048286e-04 -1.096710e-04 -1.145192e-04
## ASV2502     -3.121633e-38 -1.930013e-04 -2.020771e-04 -2.113357e-04
## ASV6742     -1.036673e-38 -6.063499e-05 -6.325798e-05 -6.597718e-05
## ASV3124     -2.035493e-38 -1.253401e-04 -1.312519e-04 -1.372491e-04
## ASV17042    -3.538879e-38 -2.195174e-04 -2.297631e-04 -2.403238e-04
## ASV0248      4.951509e-38  3.044588e-04  3.187058e-04  3.332258e-04
## ASV4557      7.240290e-39  5.129801e-05  5.380679e-05  5.659842e-05
## ASV3507     -5.318894e-38 -3.334160e-04 -3.490772e-04 -3.653067e-04
## ASV1870      3.925686e-39  2.451452e-05  2.565442e-05  2.684114e-05
## ASV2447     -2.538170e-38 -1.605589e-04 -1.681094e-04 -1.760053e-04
## ASV0347      4.138318e-38  2.607439e-04  2.730120e-04  2.857775e-04
## ASV1855     -1.910553e-38 -1.197535e-04 -1.253054e-04 -1.311309e-04
## ASV0568      1.460272e-38  9.006745e-05  9.426803e-05  9.857667e-05
## ASV1620     -2.568366e-38 -1.604123e-04 -1.678007e-04 -1.755654e-04
## ASV0101     -2.210653e-38 -1.302780e-04 -1.360795e-04 -1.419912e-04
## ASV7751      1.844488e-38  1.202780e-04  1.260394e-04  1.321393e-04
## ASV9033     -3.491267e-38 -2.191900e-04 -2.294851e-04 -2.401727e-04
## ASV3438     -9.992641e-39 -6.354684e-05 -6.650713e-05 -6.964670e-05
## ASV0637     -3.283357e-38 -2.047400e-04 -2.143703e-04 -2.242803e-04
## ASV1181     -2.405905e-38 -1.512350e-04 -1.583709e-04 -1.657528e-04
## ASV13480    -3.040027e-38 -1.905209e-04 -1.994803e-04 -2.087521e-04
## ASV14220    -3.040027e-38 -1.905209e-04 -1.994651e-04 -2.087356e-04
## ASV1448     -2.207886e-38 -1.391295e-04 -1.456730e-04 -1.524831e-04
## ASV1457      2.119314e-38  1.284985e-04  1.344113e-04  1.404352e-04
## ASV1645      1.447726e-38  9.222062e-05  9.660243e-05  1.011672e-04
## ASV2300     -2.015774e-38 -1.242406e-04 -1.300007e-04 -1.359325e-04
## ASV2533      3.110348e-38  1.911761e-04  2.001034e-04  2.092099e-04
## ASV5059      8.200787e-39  4.739254e-05  4.941722e-05  5.150959e-05
## ASV8871     -3.040027e-38 -1.905209e-04 -1.994593e-04 -2.087290e-04
## ASV1289     -3.309782e-38 -2.042898e-04 -2.137817e-04 -2.235579e-04
## ASV3983     -1.365234e-38 -8.689047e-05 -9.096320e-05 -9.525713e-05
## ASV10323    -1.041118e-38 -6.874318e-05 -7.202488e-05 -7.554881e-05
## ASV13279    -3.040027e-38 -1.905209e-04 -1.994209e-04 -2.086870e-04
## ASV7149     -3.040027e-38 -1.905209e-04 -1.994058e-04 -2.086706e-04
## ASV1691      5.674663e-39  3.634495e-05  3.797525e-05  3.978105e-05
## ASV1649      1.476393e-38  9.356678e-05  9.797366e-05  1.025752e-04
## ASV10120     4.218114e-39  2.746433e-05  2.876642e-05  3.015625e-05
## ASV8285     -3.811186e-38 -2.425896e-04 -2.541507e-04 -2.661480e-04
## ASV0037     -3.302277e-38 -2.086718e-04 -2.186016e-04 -2.288527e-04
## ASV1770      8.758316e-39  5.461805e-05  5.715598e-05  5.980205e-05
## ASV2252      8.374943e-39  5.226610e-05  5.468663e-05  5.721327e-05
## ASV7580      3.475586e-38  2.115718e-04  2.213089e-04  2.312775e-04
## ASV5643     -3.085640e-38 -1.928210e-04 -2.018508e-04 -2.112061e-04
## ASV2722     -9.384900e-39 -6.168167e-05 -6.465802e-05 -6.781417e-05
## ASV2662     -2.105348e-38 -1.322625e-04 -1.384446e-04 -1.449001e-04
## ASV0479     -4.905052e-38 -3.022591e-04 -3.162551e-04 -3.306940e-04
## ASV2009     -5.226628e-38 -3.183983e-04 -3.331569e-04 -3.481742e-04
## ASV3731     -3.492426e-38 -2.144214e-04 -2.244078e-04 -2.346096e-04
## ASV5497     -4.276841e-38 -2.650976e-04 -2.774693e-04 -2.902182e-04
## ASV6647      2.236488e-39  1.182197e-05  1.238654e-05  1.284745e-05
## ASV8974     -3.166542e-38 -1.954898e-04 -2.045657e-04 -2.139204e-04
## ASV15527     2.932468e-39  1.714342e-05  1.796233e-05  1.873531e-05
## ASV6705     -1.804951e-38 -1.197541e-04 -1.255638e-04 -1.317413e-04
## ASV0354      3.996752e-38  2.497325e-04  2.614194e-04  2.735321e-04
## ASV2707      9.718478e-39  5.743385e-05  5.995803e-05  6.256400e-05
## ASV11167    -5.281250e-38 -3.282342e-04 -3.436250e-04 -3.594538e-04
## ASV6393     -4.189279e-38 -2.611269e-04 -2.733810e-04 -2.860152e-04
## ASV3808     -3.059405e-38 -1.863782e-04 -1.952193e-04 -2.040274e-04
## ASV9337      4.645467e-39  2.605494e-05  2.719232e-05  2.829562e-05
## ASV5043     -4.300017e-38 -2.679127e-04 -2.804645e-04 -2.934193e-04
## ASV4189     -1.703631e-39 -8.022177e-06 -8.292015e-06 -8.540443e-06
## ASV1304     -1.760863e-38 -1.027025e-04 -1.071859e-04 -1.117856e-04
## ASV2105     -2.248068e-38 -1.404589e-04 -1.469656e-04 -1.537739e-04
## ASV2421     -7.654459e-39 -4.881651e-05 -5.106578e-05 -5.348460e-05
## ASV3170      3.558411e-38  2.241943e-04  2.347933e-04  2.457706e-04
## ASV5036      4.836028e-38  3.007073e-04  3.148170e-04  3.293301e-04
## ASV2286      3.040027e-38  1.897510e-04  1.985626e-04  2.077516e-04
## ASV3363      2.977992e-38  1.893119e-04  1.983785e-04  2.077394e-04
## ASV5759     -2.580681e-39 -1.740408e-05 -1.820321e-05 -1.911424e-05
## ASV5440     -2.030115e-38 -1.310067e-04 -1.372696e-04 -1.438424e-04
## ASV2050      3.623413e-38  2.186938e-04  2.287286e-04  2.389201e-04
## ASV4478      2.428010e-38  1.550368e-04  1.624293e-04  1.701267e-04
## ASV5725     -2.724618e-38 -1.677015e-04 -1.754074e-04 -1.834048e-04
## ASV1600     -6.457862e-39 -4.767228e-05 -5.015940e-05 -5.285313e-05
## ASV1654     -4.841405e-38 -2.984656e-04 -3.122540e-04 -3.265165e-04
## ASV3781     -2.119260e-38 -1.289778e-04 -1.348333e-04 -1.409007e-04
## ASV7144     -1.828655e-38 -1.106699e-04 -1.158356e-04 -1.210184e-04
## ASV12710    -7.391208e-39 -4.115443e-05 -4.288777e-05 -4.461537e-05
## ASV3317      2.424066e-38  1.503901e-04  1.573732e-04  1.646155e-04
## ASV3249     -4.736936e-38 -2.945087e-04 -3.082004e-04 -3.223989e-04
## ASV0669     -3.034387e-38 -1.840377e-04 -1.924693e-04 -2.011038e-04
## ASV0893      1.761531e-38  1.086409e-04  1.137095e-04  1.189058e-04
## ASV11060    -1.761531e-38 -1.086409e-04 -1.137009e-04 -1.188966e-04
## ASV3207      5.895205e-38  3.738704e-04  3.915441e-04  4.099673e-04
## ASV3498     -1.761531e-38 -1.086409e-04 -1.136997e-04 -1.188954e-04
## ASV4358      1.109389e-38  6.881146e-05  7.204995e-05  7.536149e-05
## ASV4806      2.999849e-38  1.863527e-04  1.951439e-04  2.041281e-04
## ASV4941      1.761531e-38  1.086409e-04  1.136950e-04  1.188903e-04
## ASV6998      5.234933e-39  3.253659e-05  3.405861e-05  3.562454e-05
## ASV7327     -1.761531e-38 -1.086409e-04 -1.136885e-04 -1.188833e-04
## ASV5112      3.482204e-38  2.192409e-04  2.295998e-04  2.403179e-04
## ASV5345     -1.761531e-38 -1.086409e-04 -1.136728e-04 -1.188664e-04
## ASV8911     -1.761531e-38 -1.086409e-04 -1.136643e-04 -1.188572e-04
## ASV5061      4.085493e-38  2.536328e-04  2.655230e-04  2.777387e-04
## ASV1968     -3.222116e-39 -2.212820e-05 -2.325291e-05 -2.443364e-05
## ASV4669     -1.761531e-38 -1.086409e-04 -1.136485e-04 -1.188401e-04
## ASV6209     -6.915139e-39 -4.043491e-05 -4.220175e-05 -4.401238e-05
## ASV6938      3.517061e-38  2.159300e-04  2.259522e-04  2.362210e-04
## ASV6987      2.003492e-38  1.201685e-04  1.256870e-04  1.312542e-04
## ASV7842     -1.761531e-38 -1.086409e-04 -1.136444e-04 -1.188355e-04
## ASV17950     1.404325e-53  4.153973e-08  7.060140e-08  7.535778e-08
## ASV3380     -5.168331e-38 -3.164074e-04 -3.311699e-04 -3.461813e-04
## ASV13740    -4.294788e-38 -2.693768e-04 -2.820232e-04 -2.951443e-04
## ASV4313     -2.528080e-38 -1.581179e-04 -1.654718e-04 -1.731434e-04
## ASV3891     -2.793767e-38 -1.646700e-04 -1.723195e-04 -1.798107e-04
## ASV3322     -3.070413e-38 -1.913492e-04 -2.002732e-04 -2.095279e-04
## ASV1668     -5.073826e-39 -3.295342e-05 -3.445860e-05 -3.612549e-05
## ASV1739      1.243720e-38  7.424952e-05  7.757296e-05  8.098769e-05
## ASV3194      2.457088e-38  1.525291e-04  1.596033e-04  1.669464e-04
## ASV0071     -3.885679e-38 -2.304160e-04 -2.406914e-04 -2.512234e-04
## ASV0695      1.737182e-38  1.105566e-04  1.157141e-04  1.211627e-04
## ASV3835     -1.421637e-38 -8.662171e-05 -9.066189e-05 -9.474988e-05
## ASV1876      1.410429e-38  8.928754e-05  9.353481e-05  9.792487e-05
## ASV4892     -4.246804e-38 -2.653634e-04 -2.778638e-04 -2.907405e-04
## ASV1212     -1.477617e-38 -9.152865e-05 -9.575942e-05 -1.001579e-04
## ASV2640      3.628634e-40  1.380846e-06  1.346229e-06  1.361058e-06
## ASV7236     -4.178066e-38 -2.623329e-04 -2.746554e-04 -2.874474e-04
## ASV2353     -1.136627e-38 -7.330739e-05 -7.677952e-05 -8.045591e-05
## ASV0276      5.297941e-38  3.195025e-04  3.345086e-04  3.494365e-04
## ASV2262     -1.567746e-38 -9.738002e-05 -1.018208e-04 -1.065136e-04
## ASV11201    -1.012069e-38 -6.505832e-05 -6.812014e-05 -7.136842e-05
## ASV0665      4.368155e-39  2.630232e-05  2.750677e-05  2.873579e-05
## ASV5238      5.689398e-39  2.707901e-05  2.796191e-05  2.882414e-05
## ASV6885     -2.331070e-38 -1.441928e-04 -1.508976e-04 -1.578152e-04
## ASV1844      8.573873e-39  5.835171e-05  6.118078e-05  6.426061e-05
## ASV0379      3.040027e-38  1.881053e-04  1.968199e-04  2.058426e-04
## ASV1040     -9.902104e-39 -5.901721e-05 -6.163289e-05 -6.434318e-05
## ASV7913     -1.752280e-38 -1.091092e-04 -1.141778e-04 -1.194457e-04
## ASV1197     -3.040027e-38 -1.881053e-04 -1.967934e-04 -2.058138e-04
## ASV5918      1.299749e-38  8.135371e-05  8.522954e-05  8.918852e-05
## ASV8045      6.221209e-39  4.193262e-05  4.406153e-05  4.625739e-05
## ASV16458    -3.472051e-39 -1.902343e-05 -1.977009e-05 -2.054654e-05
## ASV10827    -3.040027e-38 -1.881053e-04 -1.967829e-04 -2.058023e-04
## ASV3658     -3.040027e-38 -1.881053e-04 -1.967682e-04 -2.057863e-04
## ASV0073     -6.214215e-38 -3.897822e-04 -4.080578e-04 -4.270334e-04
## ASV1951     -1.155586e-38 -7.843090e-05 -8.238386e-05 -8.651478e-05
## ASV7630     -3.993133e-38 -2.479903e-04 -2.596152e-04 -2.715665e-04
## ASV9449     -2.069183e-38 -1.320937e-04 -1.384554e-04 -1.450124e-04
## ASV3944      4.302148e-38  2.663418e-04  2.787381e-04  2.915314e-04
## ASV1520     -5.841721e-38 -3.603328e-04 -3.770869e-04 -3.943150e-04
## ASV0307      4.418851e-38  2.782776e-04  2.914286e-04  3.050469e-04
## ASV12731    -1.095031e-38 -7.059797e-05 -7.391422e-05 -7.745308e-05
## ASV0282      4.436702e-38  2.794136e-04  2.925968e-04  3.062694e-04
## ASV2646      4.152743e-38  2.509374e-04  2.625104e-04  2.742390e-04
## ASV3536      3.198782e-38  1.993123e-04  2.086419e-04  2.182783e-04
## ASV10089    -3.040027e-38 -1.836718e-04 -1.921487e-04 -2.007331e-04
## ASV1185      3.040027e-38  1.836717e-04  1.921343e-04  2.007179e-04
## ASV1452      3.040027e-38  1.836717e-04  1.921201e-04  2.007027e-04
## ASV1700      3.040027e-38  1.836717e-04  1.921058e-04  2.006875e-04
## ASV6948     -3.040027e-38 -1.836717e-04 -1.920916e-04 -2.006723e-04
## ASV0389     -3.943704e-38 -2.396933e-04 -2.507067e-04 -2.619775e-04
## ASV11884    -5.253884e-40  1.887392e-06  2.177311e-06  2.536095e-06
## ASV23165    -3.040027e-38 -1.836716e-04 -1.920605e-04 -2.006392e-04
## ASV2841      3.040027e-38  1.836716e-04  1.920464e-04  2.006240e-04
## ASV2949      3.040027e-38  1.836716e-04  1.920323e-04  2.006088e-04
## ASV4037      3.040027e-38  1.836716e-04  1.920181e-04  2.005936e-04
## ASV4477      3.040027e-38  1.836715e-04  1.920041e-04  2.005784e-04
## ASV4496      3.040027e-38  1.836715e-04  1.919900e-04  2.005633e-04
## ASV5784     -3.040027e-38 -1.836715e-04 -1.919760e-04 -2.005481e-04
## ASV6035      1.907164e-40  4.395966e-06  4.807635e-06  5.194309e-06
## ASV6232     -3.045296e-38 -1.839988e-04 -1.923052e-04 -2.008920e-04
## ASV1818      3.040027e-38  1.836715e-04  1.919485e-04  2.005183e-04
## ASV2595      3.040027e-38  1.836714e-04  1.919345e-04  2.005031e-04
## ASV2788     -3.942844e-39 -2.394801e-05 -2.519668e-05 -2.633223e-05
## ASV5018      3.040027e-38  1.836714e-04  1.919219e-04  2.004892e-04
## ASV0127      3.946275e-38  2.482308e-04  2.599069e-04  2.720360e-04
## ASV1527      6.855792e-40  5.752538e-06  6.058213e-06  6.411032e-06
## ASV1055      2.270216e-38  1.409741e-04  1.475074e-04  1.542930e-04
## ASV4791      1.644295e-38  9.131001e-05  9.517163e-05  9.900267e-05
## ASV0859      1.646178e-38  1.008136e-04  1.054603e-04  1.102364e-04
## ASV12971    -4.307029e-38 -2.686408e-04 -2.811692e-04 -2.941669e-04
## ASV16856    -4.307029e-38 -2.686408e-04 -2.811480e-04 -2.941438e-04
## ASV7321     -3.513345e-38 -2.194858e-04 -2.296870e-04 -2.403210e-04
## ASV8780     -4.307029e-38 -2.686407e-04 -2.811100e-04 -2.941024e-04
## ASV1569      3.172041e-38  1.968608e-04  2.059894e-04  2.154612e-04
## ASV3696      5.300945e-39  3.170304e-05  3.321207e-05  3.467750e-05
## ASV0624      5.823903e-38  3.601778e-04  3.769539e-04  3.942383e-04
## ASV0495      3.590085e-38  2.196109e-04  2.298681e-04  2.402786e-04
## ASV16971    -1.761531e-38 -1.097604e-04 -1.148405e-04 -1.201437e-04
## ASV6535      9.535005e-39  6.230118e-05  6.536808e-05  6.853862e-05
## ASV1897      4.203325e-38  2.577896e-04  2.697373e-04  2.819901e-04
## ASV2631     -4.658649e-39 -3.305485e-05 -3.476329e-05 -3.657832e-05
## ASV6204      1.368773e-38  8.641016e-05  9.052689e-05  9.476468e-05
## ASV3312     -2.647859e-38 -1.655328e-04 -1.732653e-04 -1.813006e-04
## ASV3360      1.640577e-38  1.046865e-04  1.097151e-04  1.149091e-04
## ASV3907      7.881744e-39  5.085462e-05  5.329517e-05  5.584468e-05
## ASV6090      8.337117e-39  5.234602e-05  5.486479e-05  5.741667e-05
## ASV8652     -1.007941e-38 -6.049137e-05 -6.322716e-05 -6.602966e-05
## ASV11129    -1.761531e-38 -1.086439e-04 -1.136612e-04 -1.188561e-04
## ASV11073    -1.761531e-38 -1.086439e-04 -1.136527e-04 -1.188469e-04
## ASV1840      5.907088e-38  3.635740e-04  3.804621e-04  3.978021e-04
## ASV2298      2.253527e-38  1.373399e-04  1.435990e-04  1.500772e-04
## ASV2420      5.218580e-38  3.255549e-04  3.408462e-04  3.566138e-04
## ASV6474      6.881894e-39  4.447268e-05  4.659975e-05  4.882952e-05
## ASV8475     -1.761531e-38 -1.086439e-04 -1.136414e-04 -1.188346e-04
## ASV8679     -1.761531e-38 -1.086439e-04 -1.136329e-04 -1.188254e-04
## ASV6527      1.636266e-38  1.033785e-04  1.082870e-04  1.133640e-04
## ASV2504     -2.342292e-39 -1.701805e-05 -1.805959e-05 -1.902135e-05
## ASV1093     -1.855121e-38 -1.151657e-04 -1.206555e-04 -1.262068e-04
## ASV0994      2.435005e-38  1.518091e-04  1.588878e-04  1.662320e-04
## ASV0092     -3.956158e-38 -2.502154e-04 -2.620735e-04 -2.743717e-04
## ASV2619      8.953795e-39  5.682656e-05  5.950699e-05  6.230727e-05
## ASV0121      5.274311e-38  3.169921e-04  3.315391e-04  3.462633e-04
## ASV0932      1.695377e-38  1.087630e-04  1.140434e-04  1.194699e-04
## ASV5229      2.968493e-38  1.819664e-04  1.904423e-04  1.990838e-04
## ASV6737      2.965703e-38  1.854651e-04  1.941825e-04  2.031863e-04
## ASV11213    -4.307029e-38 -2.617404e-04 -2.738407e-04 -2.861503e-04
## ASV1151      8.692754e-38  5.397372e-04  5.649492e-04  5.909473e-04
## ASV3813      4.616307e-38  2.819419e-04  2.950099e-04  3.083429e-04
## ASV5566      8.269295e-39  5.835884e-05  6.123636e-05  6.441439e-05
## ASV7529     -4.307029e-38 -2.617404e-04 -2.738094e-04 -2.861171e-04
## ASV2193      5.998846e-38  3.774299e-04  3.951882e-04  4.136305e-04
## ASV2349      5.562478e-38  3.470905e-04  3.633022e-04  3.801135e-04
## ASV2387      5.028924e-38  3.048239e-04  3.188197e-04  3.331089e-04
## ASV2699      3.988293e-38  2.535973e-04  2.656059e-04  2.781403e-04
## ASV3353      5.360171e-38  3.309599e-04  3.463798e-04  3.622217e-04
## ASV3621      2.915574e-38  1.762725e-04  1.843890e-04  1.926314e-04
## ASV3848      4.837844e-39  3.128401e-05  3.276725e-05  3.434004e-05
## ASV4440     -6.352699e-41  4.050718e-06  4.405358e-06  4.837522e-06
## ASV4751      5.590983e-38  3.488976e-04  3.652461e-04  3.821470e-04
## ASV5115      2.366276e-38  1.495516e-04  1.565516e-04  1.638856e-04
## ASV5850     -4.307029e-38 -2.617404e-04 -2.737556e-04 -2.860594e-04
## ASV6293      2.597579e-38  1.618460e-04  1.694300e-04  1.772549e-04
## ASV6513      1.071533e-38  7.121434e-05  7.468335e-05  7.836314e-05
## ASV7628     -4.307029e-38 -2.617403e-04 -2.737388e-04 -2.860415e-04
## ASV7658      2.525182e-38  1.598704e-04  1.674603e-04  1.753190e-04
## ASV0776     -5.032782e-38 -3.078551e-04 -3.221308e-04 -3.367132e-04
## ASV10227    -4.307029e-38 -2.617403e-04 -2.737206e-04 -2.860220e-04
## ASV11965    -4.307029e-38 -2.617403e-04 -2.737004e-04 -2.860002e-04
## ASV1270     -1.490230e-38 -8.860726e-05 -9.257232e-05 -9.662802e-05
## ASV13123    -3.272211e-38 -1.976928e-04 -2.066335e-04 -2.158574e-04
## ASV5828      4.307029e-38  2.617402e-04  2.736608e-04  2.859574e-04
## ASV5920     -4.307029e-38 -2.617402e-04 -2.736406e-04 -2.859357e-04
## ASV6071      3.957039e-38  2.486370e-04  2.603211e-04  2.724560e-04
## ASV6723     -2.495385e-39 -1.253460e-05 -1.295282e-05 -1.339546e-05
## ASV6727     -4.307029e-38 -2.617402e-04 -2.736154e-04 -2.859083e-04
## ASV7759     -4.307029e-38 -2.617402e-04 -2.735954e-04 -2.858865e-04
## ASV0733      2.834952e-39  1.855604e-05  1.931494e-05  2.025628e-05
## ASV1655     -5.682449e-39 -3.967576e-05 -4.158858e-05 -4.372861e-05
## ASV0755     -6.353015e-38 -3.894472e-04 -4.073588e-04 -4.258463e-04
## ASV0796      2.692328e-38  1.585093e-04  1.656820e-04  1.728670e-04
## ASV0878      5.441067e-38  3.375729e-04  3.533016e-04  3.695438e-04
## ASV4988     -3.372883e-38 -2.095773e-04 -2.193236e-04 -2.294220e-04
## ASV0083     -3.793139e-38 -2.393064e-04 -2.504600e-04 -2.621694e-04
## ASV0273      1.920534e-38  1.125401e-04  1.176782e-04  1.227633e-04
## ASV3076      1.240580e-38  7.870319e-05  8.242472e-05  8.630384e-05
## ASV1513      1.050208e-38  6.458104e-05  6.758700e-05  7.066383e-05
## ASV5159     -2.985012e-39 -1.624088e-05 -1.700274e-05 -1.767171e-05
## ASV3422     -2.540820e-38 -1.594330e-04 -1.669272e-04 -1.746972e-04
## ASV12230    -3.949073e-39 -2.278930e-05 -2.378149e-05 -2.478661e-05
## ASV1694      5.402647e-38  3.295663e-04  3.450061e-04  3.605946e-04
## ASV1249      2.316279e-38  1.443687e-04  1.513080e-04  1.583013e-04
## ASV1697     -1.306938e-38 -7.987341e-05 -8.354261e-05 -8.732182e-05
## ASV4408     -3.326927e-38 -1.956375e-04 -2.045538e-04 -2.134221e-04
## ASV0095     -3.882255e-38 -2.467145e-04 -2.584385e-04 -2.706264e-04
## ASV0410      5.776032e-40  7.492326e-07  7.988490e-07  6.887258e-07
## ASV4642     -4.938669e-38 -3.083709e-04 -3.228478e-04 -3.377948e-04
## ASV4560     -6.902655e-40 -1.285875e-06 -1.227690e-06 -1.127655e-06
## ASV7586     -2.315701e-38 -1.453020e-04 -1.521121e-04 -1.591888e-04
## ASV4144     -2.590330e-38 -1.634479e-04 -1.711942e-04 -1.792094e-04
## ASV0327     -2.868261e-38 -1.772832e-04 -1.854689e-04 -1.939592e-04
## ASV0946     -2.519712e-38 -1.495930e-04 -1.562495e-04 -1.630983e-04
## ASV3254     -3.040027e-38 -1.915048e-04 -2.005474e-04 -2.099193e-04
## ASV0349      4.421535e-38  2.765811e-04  2.895279e-04  3.029543e-04
## ASV0472     -2.726909e-38 -1.686451e-04 -1.764404e-04 -1.845216e-04
## ASV1330      2.820047e-38  1.697962e-04  1.775103e-04  1.854038e-04
## ASV2605      2.879268e-38  1.801422e-04  1.886077e-04  1.973548e-04
## ASV2846     -1.596366e-38 -1.028551e-04 -1.078198e-04 -1.129749e-04
## ASV3982     -1.316464e-38 -8.376402e-05 -8.776630e-05 -9.191283e-05
## ASV4116     -3.040027e-38 -1.915048e-04 -2.005206e-04 -2.098901e-04
## ASV6048     -1.771592e-38 -1.121393e-04 -1.174240e-04 -1.229382e-04
## ASV1146      3.722078e-38  2.311775e-04  2.419642e-04  2.530975e-04
## ASV13362     2.410474e-39  1.354106e-05  1.411190e-05  1.468593e-05
## ASV1422     -3.040027e-38 -1.915048e-04 -2.005008e-04 -2.098684e-04
## ASV3640     -3.040027e-38 -1.915048e-04 -2.004855e-04 -2.098518e-04
## ASV5404      2.487178e-38  1.501311e-04  1.569513e-04  1.639555e-04
## ASV6118     -3.040027e-38 -1.915048e-04 -2.004754e-04 -2.098406e-04
## ASV1115     -2.592496e-38 -1.633836e-04 -1.711208e-04 -1.791181e-04
## ASV0888     -5.620737e-38 -3.499158e-04 -3.662958e-04 -3.832004e-04
## ASV4620      9.189096e-39  4.593700e-05  4.765461e-05  4.928630e-05
## ASV3099      1.058778e-38  6.874081e-05  7.207765e-05  7.554987e-05
## ASV7099      4.881364e-39  3.195980e-05  3.349444e-05  3.511961e-05
## ASV5892     -3.530855e-38 -2.203287e-04 -2.306167e-04 -2.412852e-04
## ASV6978     -3.485570e-38 -2.193499e-04 -2.296534e-04 -2.403764e-04
## ASV6555     -1.067276e-38 -7.435287e-05 -7.807952e-05 -8.208802e-05
## ASV0539     -4.482517e-38 -2.765803e-04 -2.894454e-04 -3.026766e-04
## ASV4665      1.324299e-38  7.772118e-05  8.109831e-05  8.459836e-05
## ASV2210      2.825782e-38  1.667676e-04  1.742252e-04  1.818285e-04
## ASV1329      2.770622e-38  1.747183e-04  1.829891e-04  1.915458e-04
## ASV7123     -4.034530e-38 -2.536486e-04 -2.655947e-04 -2.779841e-04
## ASV1260      1.515010e-40  1.602765e-06  1.736959e-06  1.851800e-06
## ASV1011      4.056037e-38  2.587658e-04  2.711650e-04  2.840026e-04
## ASV4233      1.112053e-38  7.075386e-05  7.416436e-05  7.766654e-05
## ASV1475      4.274011e-38  2.634608e-04  2.757043e-04  2.883067e-04
## ASV6099     -4.940898e-38 -3.051499e-04 -3.192425e-04 -3.338461e-04
## ASV1428     -1.827989e-39  1.212189e-06  1.570192e-06  2.284201e-06
## ASV5101     -5.283484e-38 -3.343444e-04 -3.501364e-04 -3.665826e-04
## ASV11827    -2.412558e-38 -1.508786e-04 -1.579247e-04 -1.652479e-04
## ASV13899    -2.744962e-38 -1.715828e-04 -1.795753e-04 -1.878971e-04
## ASV21259    -3.208564e-38 -2.014207e-04 -2.108433e-04 -2.206607e-04
## ASV6635     -1.557054e-38 -9.955787e-05 -1.042202e-04 -1.091644e-04
## ASV9922     -4.307029e-38 -2.700159e-04 -2.826081e-04 -2.957450e-04
## ASV2869      5.465388e-39  3.326308e-05  3.476409e-05  3.632420e-05
## ASV1740      2.859320e-38  1.764195e-04  1.845273e-04  1.929586e-04
## ASV4406     -4.307029e-38 -2.719506e-04 -2.847638e-04 -2.981074e-04
## ASV5586     -3.647324e-38 -2.318716e-04 -2.428273e-04 -2.542855e-04
## ASV3255     -1.485802e-38 -9.211569e-05 -9.636501e-05 -1.007923e-04
## ASV12281    -2.116552e-38 -1.292840e-04 -1.352353e-04 -1.413533e-04
## ASV5388     -4.200144e-38 -2.550696e-04 -2.665704e-04 -2.785347e-04
## ASV17660    -4.183487e-38 -2.614306e-04 -2.737171e-04 -2.864016e-04
## ASV0159      2.400975e-38  1.438752e-04  1.507596e-04  1.574572e-04
## ASV2734     -6.251970e-38 -3.877501e-04 -4.058624e-04 -4.245194e-04
## ASV2049      4.712326e-39  2.943501e-05  3.087015e-05  3.230364e-05
## ASV2465      3.938409e-39  1.907255e-05  1.968556e-05  2.031965e-05
## ASV2147      2.099095e-38  1.210422e-04  1.262450e-04  1.315869e-04
## ASV3113     -6.098769e-39 -3.738119e-05 -3.912354e-05 -4.089480e-05
## ASV0622     -4.377638e-38 -2.747271e-04 -2.877075e-04 -3.010969e-04
## ASV0437     -4.440115e-38 -2.756528e-04 -2.885066e-04 -3.017793e-04
## ASV6385     -4.813332e-38 -3.013249e-04 -3.154880e-04 -3.301351e-04
## ASV3699     -4.307029e-38 -2.733004e-04 -2.862104e-04 -2.996905e-04
## ASV2208      4.307029e-38  2.733004e-04  2.861885e-04  2.996665e-04
## ASV1053      1.007388e-38  6.256372e-05  6.541281e-05  6.842454e-05
## ASV8468     -1.004395e-38 -6.131065e-05 -6.408141e-05 -6.697446e-05
## ASV0951     -3.714148e-38 -2.293420e-04 -2.402073e-04 -2.512004e-04
## ASV0278      5.376201e-38  3.284969e-04  3.435463e-04  3.590807e-04
## ASV0914     -2.767334e-38 -1.715913e-04 -1.796734e-04 -1.879289e-04
## ASV0737      4.307029e-38  2.566249e-04  2.685069e-04  2.803226e-04
## ASV2038      6.043088e-38  3.703824e-04  3.876006e-04  4.051915e-04
## ASV2171      3.803113e-38  2.253047e-04  2.356980e-04  2.460023e-04
## ASV2607      4.307029e-38  2.566248e-04  2.684603e-04  2.802737e-04
## ASV3143      3.311421e-38  1.949402e-04  2.038840e-04  2.127327e-04
## ASV3187     -4.610563e-38 -2.753502e-04 -2.880153e-04 -3.007228e-04
## ASV3810      4.307029e-38  2.566247e-04  2.684046e-04  2.802155e-04
## ASV5060     -2.692454e-38 -1.580480e-04 -1.652757e-04 -1.724264e-04
## ASV5325      4.307029e-38  2.566246e-04  2.683737e-04  2.801831e-04
## ASV6905     -4.307029e-38 -2.566245e-04 -2.683539e-04 -2.801623e-04
## ASV7597     -4.307029e-38 -2.566245e-04 -2.683341e-04 -2.801414e-04
## ASV9652     -4.307029e-38 -2.566244e-04 -2.683144e-04 -2.801205e-04
## ASV2634      4.307029e-38  2.566244e-04  2.682947e-04  2.800997e-04
## ASV3065      4.307029e-38  2.566243e-04  2.682750e-04  2.800788e-04
## ASV3331      4.307029e-38  2.566243e-04  2.682554e-04  2.800580e-04
## ASV7434     -4.307029e-38 -2.566242e-04 -2.682358e-04 -2.800371e-04
## ASV7720      5.262120e-39  4.061806e-05  4.279078e-05  4.516286e-05
## ASV8414     -4.307029e-38 -2.566241e-04 -2.682181e-04 -2.800183e-04
## ASV12139    -4.307029e-38 -2.566241e-04 -2.681985e-04 -2.799975e-04
## ASV1824      4.202166e-38  2.501149e-04  2.613643e-04  2.728484e-04
## ASV2094      4.253947e-38  2.534159e-04  2.648057e-04  2.764522e-04
## ASV2770     -8.408167e-39 -5.783772e-05 -6.073838e-05 -6.381598e-05
## ASV3505     -2.190723e-38 -1.243465e-04 -1.296736e-04 -1.350483e-04
## ASV1935      4.307029e-38  2.566239e-04  2.681353e-04  2.799299e-04
## ASV5764     -4.307029e-38 -2.566238e-04 -2.681159e-04 -2.799091e-04
## ASV6806      2.558184e-38  1.629887e-04  1.707455e-04  1.788156e-04
## ASV6942     -4.307029e-38 -2.566238e-04 -2.680979e-04 -2.798897e-04
## ASV1166      4.710626e-38  2.819594e-04  2.946021e-04  3.076267e-04
## ASV1664      3.290420e-38  2.000743e-04  2.092931e-04  2.187048e-04
## ASV2568      4.307029e-38  2.566237e-04  2.680606e-04  2.798495e-04
## ASV3525      4.307029e-38  2.566236e-04  2.680414e-04  2.798287e-04
## ASV4965     -5.043521e-38 -3.065292e-04 -3.205224e-04 -3.349348e-04
## ASV6607     -2.751995e-38 -1.591944e-04 -1.660156e-04 -1.730600e-04
## ASV7187      1.411339e-38  8.663972e-05  9.075806e-05  9.488278e-05
## ASV0388     -3.960348e-38 -2.526750e-04 -2.646906e-04 -2.772245e-04
## ASV1420      3.510812e-54  1.571938e-06  1.691733e-06  1.848604e-06
## ASV14293     1.257258e-38  8.194753e-05  8.587536e-05  9.002686e-05
## ASV17785     3.510812e-54  1.571939e-06  1.685477e-06  1.841612e-06
## ASV7678      3.797204e-39  1.642073e-05  1.695047e-05  1.736866e-05
## ASV2253      1.063109e-38  6.912819e-05  7.246707e-05  7.596185e-05
## ASV4150      2.316890e-38  1.396698e-04  1.460753e-04  1.525896e-04
## ASV3836     -5.193631e-38 -3.221550e-04 -3.371378e-04 -3.526384e-04
## ASV16231    -4.180607e-38 -2.638532e-04 -2.762759e-04 -2.892153e-04
## ASV2730      8.527633e-40  5.292177e-06  5.574844e-06  5.833435e-06
## ASV2072      2.542236e-38  1.508206e-04  1.574834e-04  1.643750e-04
## ASV2160      5.778867e-39  3.975964e-05  4.175870e-05  4.388312e-05
## ASV5013      8.554903e-39  4.936533e-05  5.156648e-05  5.374217e-05
## ASV2586      1.430819e-38  8.802629e-05  9.213416e-05  9.632767e-05
## ASV1442      1.097388e-38  6.892946e-05  7.218801e-05  7.554119e-05
## ASV3101      1.706056e-38  9.900269e-05  1.033397e-04  1.077368e-04
## ASV3323     -1.268229e-38 -8.179955e-05 -8.572360e-05 -8.978671e-05
## ASV1812      4.250432e-38  2.531091e-04  2.643193e-04  2.759337e-04
## ASV6120     -4.295281e-39 -2.955501e-05 -3.095996e-05 -3.253172e-05
## ASV2565      9.308136e-39  5.521255e-05  5.769090e-05  6.021663e-05
## ASV6687      4.647897e-39  2.823550e-05  2.959676e-05  3.092824e-05
## ASV5357     -3.544703e-38 -2.205527e-04 -2.307887e-04 -2.414284e-04
## ASV9383      1.822722e-38  1.099564e-04  1.149650e-04  1.200939e-04
## ASV11753    -3.040027e-38 -1.888235e-04 -1.975497e-04 -2.066403e-04
## ASV11512    -8.443889e-39 -5.244308e-05 -5.478460e-05 -5.730400e-05
## ASV2791     -1.001107e-39 -8.135342e-06 -8.525973e-06 -9.015298e-06
## ASV0664     -6.462177e-38 -3.993651e-04 -4.179315e-04 -4.370636e-04
## ASV3436      5.808385e-39  4.069525e-05  4.276957e-05  4.498399e-05
## ASV5755      4.420510e-38  2.720176e-04  2.846754e-04  2.976481e-04
## ASV10970    -4.307029e-38 -2.673211e-04 -2.797787e-04 -2.926449e-04
## ASV11798    -2.199585e-38 -1.364456e-04 -1.427585e-04 -1.493189e-04
## ASV18193    -4.307029e-38 -2.673211e-04 -2.797484e-04 -2.926120e-04
## ASV2548      4.604562e-38  2.816031e-04  2.945793e-04  3.079195e-04
## ASV3901      4.976453e-38  3.043360e-04  3.183977e-04  3.328187e-04
## ASV5197      1.984404e-39  6.046621e-06  6.059893e-06  6.028077e-06
## ASV5859      2.205638e-38  1.351086e-04  1.413163e-04  1.477291e-04
## ASV6240     -4.307029e-38 -2.673211e-04 -2.797364e-04 -2.925990e-04
## ASV7281      4.307029e-38  2.673211e-04  2.797154e-04  2.925761e-04
## ASV7635      2.394249e-38  1.499143e-04  1.570449e-04  1.643373e-04
## ASV8822     -4.307029e-38 -2.673211e-04 -2.796986e-04 -2.925578e-04
## ASV4810     -9.716380e-39 -5.718307e-05 -5.967421e-05 -6.225001e-05
## ASV5308      4.502545e-38  2.796865e-04  2.926489e-04  3.061183e-04
## ASV2749     -4.899388e-38 -3.059635e-04 -3.203243e-04 -3.351561e-04
## ASV0298      2.639139e-39  2.279277e-05  2.402761e-05  2.546266e-05
## ASV2597     -4.580768e-38 -2.868280e-04 -3.002843e-04 -3.142269e-04
## ASV5758     -1.920718e-38 -1.195607e-04 -1.251098e-04 -1.308836e-04
## ASV9987     -4.866217e-38 -3.032334e-04 -3.174747e-04 -3.321428e-04
## ASV0971      1.099668e-38  6.205989e-05  6.463759e-05  6.731508e-05
## ASV0627     -4.718140e-38 -2.958515e-04 -3.097660e-04 -3.241716e-04
## ASV1758      4.324426e-38  2.683308e-04  2.808738e-04  2.937922e-04
## ASV4559      3.105208e-41  1.040685e-06  1.142798e-06  1.236422e-06
## ASV11400    -2.171883e-39 -1.139180e-05 -1.181606e-05 -1.224791e-05
## ASV11559    -4.307029e-38 -2.696797e-04 -2.822674e-04 -2.953731e-04
## ASV3943     -4.307029e-38 -2.696797e-04 -2.822461e-04 -2.953498e-04
## ASV10389     8.575378e-39  5.071946e-05  5.301688e-05  5.532375e-05
## ASV5168      3.935741e-38  2.391267e-04  2.500863e-04  2.613262e-04
## ASV5724      2.652547e-38  1.663954e-04  1.742016e-04  1.823027e-04
## ASV6337      9.187161e-39  5.280600e-05  5.515180e-05  5.747095e-05
## ASV11063     2.537146e-38  1.515844e-04  1.583691e-04  1.653541e-04
## ASV4279     -4.630236e-39 -2.878385e-05 -3.012631e-05 -3.151450e-05
## ASV7660     -1.761531e-38 -1.115776e-04 -1.168582e-04 -1.223520e-04
## ASV8218     -1.761531e-38 -1.115776e-04 -1.168492e-04 -1.223422e-04
## ASV3574      6.944116e-38  4.378850e-04  4.585138e-04  4.799633e-04
## ASV12050    -1.761531e-38 -1.115776e-04 -1.168509e-04 -1.223441e-04
## ASV3897      1.656826e-38  1.002116e-04  1.047675e-04  1.094538e-04
## ASV3856     -5.419528e-38 -3.370846e-04 -3.527198e-04 -3.689691e-04
## ASV3024     -1.626094e-38 -1.060031e-04 -1.111534e-04 -1.165177e-04
## ASV8715     -4.213741e-38 -2.620844e-04 -2.743586e-04 -2.870088e-04
## ASV6917     -1.897001e-38 -1.110731e-04 -1.165698e-04 -1.215956e-04
## ASV1132      4.288932e-38  2.709730e-04  2.837071e-04  2.970075e-04
## ASV3583      2.137766e-38  1.361746e-04  1.426156e-04  1.493593e-04
## ASV0328      6.940724e-38  4.328533e-04  4.530647e-04  4.740162e-04
## ASV0915     -2.286033e-38 -1.449221e-04 -1.517378e-04 -1.588775e-04
## ASV2677      2.287369e-38  1.464084e-04  1.534013e-04  1.606870e-04
## ASV0599      2.437626e-38  1.484958e-04  1.555472e-04  1.625706e-04
## ASV0283     -6.365478e-38 -3.948659e-04 -4.132492e-04 -4.322484e-04
## ASV1028      2.574698e-38  1.631557e-04  1.708550e-04  1.788878e-04
## ASV0523      4.734915e-38  2.973444e-04  3.113586e-04  3.258603e-04
## ASV8201     -2.876728e-38 -1.812237e-04 -1.897037e-04 -1.985604e-04
## ASV2795     -9.235616e-39 -5.702945e-05 -5.961095e-05 -6.233767e-05
## ASV3563     -9.221702e-39 -5.694375e-05 -5.951687e-05 -6.223902e-05
## ASV1553     -1.754869e-38 -1.041521e-04 -1.088412e-04 -1.136111e-04
## ASV7155     -3.487376e-39 -2.817697e-05 -2.987657e-05 -3.156561e-05
## ASV0365      6.180454e-38  3.813607e-04  3.988929e-04  4.171273e-04
## ASV8583     -4.243646e-38 -2.619264e-04 -2.742137e-04 -2.867546e-04
## ASV5400      2.085204e-39  1.376740e-05  1.451267e-05  1.521995e-05
## ASV5908      3.356348e-38  2.031431e-04  2.123831e-04  2.218824e-04
## ASV2075      1.818949e-38  1.145834e-04  1.199031e-04  1.255022e-04
## ASV2520     -3.626775e-38 -2.283956e-04 -2.391601e-04 -2.503346e-04
## ASV9596     -1.877930e-38 -1.127992e-04 -1.179923e-04 -1.232304e-04
## ASV1131     -6.844056e-39 -3.793478e-05 -3.964728e-05 -4.124734e-05
## ASV0579     -1.208585e-38 -7.442018e-05 -7.792005e-05 -8.147643e-05
## ASV0288     -5.926669e-38 -3.643685e-04 -3.812712e-04 -3.986319e-04
## ASV4053      1.077875e-38  6.080044e-05  6.327282e-05  6.587280e-05
## ASV1736     -3.131613e-38 -1.944688e-04 -2.034869e-04 -2.128489e-04
## ASV1254      3.310807e-38  2.006146e-04  2.098590e-04  2.192681e-04
## ASV9038     -5.084157e-38 -3.180228e-04 -3.328625e-04 -3.482917e-04
## ASV4746      4.588977e-38  2.897996e-04  3.034826e-04  3.177054e-04
## ASV5803      1.761531e-38  1.100535e-04  1.151690e-04  1.205039e-04
## ASV0525      1.929316e-39  1.258201e-05  1.318450e-05  1.382279e-05
## ASV1974      2.791714e-38  1.682534e-04  1.759421e-04  1.837762e-04
## ASV1827      4.617373e-38  2.816133e-04  2.945775e-04  3.078740e-04
## ASV30780     2.561976e-39  1.396504e-05  1.457628e-05  1.514489e-05
## ASV9342      1.273144e-39  1.014228e-05  1.071326e-05  1.132423e-05
## ASV21626    -4.298399e-38 -2.658886e-04 -2.782786e-04 -2.910282e-04
## ASV1232     -3.066290e-38 -1.881926e-04 -1.969545e-04 -2.059084e-04
## ASV5578     -3.040027e-38 -1.898392e-04 -1.986837e-04 -2.078813e-04
## ASV5868      3.312771e-38  2.000335e-04  2.091247e-04  2.184663e-04
## ASV13625    -1.350441e-38 -8.275524e-05 -8.653603e-05 -9.045893e-05
## ASV3614      5.417200e-39  3.094305e-05  3.227311e-05  3.362155e-05
## ASV2128      2.723657e-38  1.713525e-04  1.794265e-04  1.877972e-04
## ASV5086      6.196260e-39  3.759036e-05  3.933144e-05  4.109395e-05
## ASV6614     -3.040027e-38 -1.898392e-04 -1.986755e-04 -2.078722e-04
## ASV9451     -3.040027e-38 -1.898392e-04 -1.986606e-04 -2.078559e-04
## ASV9533     -3.040027e-38 -1.898392e-04 -1.986457e-04 -2.078396e-04
## ASV10697    -9.830274e-53  2.142690e-06  2.322016e-06  2.539594e-06
## ASV1473     -1.496456e-38 -8.943462e-05 -9.343839e-05 -9.755951e-05
## ASV1414     -8.822413e-39 -5.618440e-05 -5.885656e-05 -6.162953e-05
## ASV1567     -8.185222e-39 -5.485370e-05 -5.749020e-05 -6.034675e-05
## ASV6395     -3.040027e-38 -1.912331e-04 -2.001939e-04 -2.095365e-04
## ASV2366      1.339779e-38  7.753935e-05  8.099022e-05  8.442544e-05
## ASV2537      1.318291e-38  7.725440e-05  8.071067e-05  8.419095e-05
## ASV5378     -3.040027e-38 -1.912332e-04 -2.001870e-04 -2.095286e-04
## ASV5929     -3.202008e-38 -2.012905e-04 -2.106992e-04 -2.205236e-04
## ASV6360      2.635489e-38  1.602062e-04  1.676351e-04  1.751704e-04
## ASV7916     -4.739203e-39 -3.220451e-05 -3.375684e-05 -3.545780e-05
## ASV13322     9.764211e-39  6.323345e-05  6.632212e-05  6.951105e-05
## ASV6207     -3.894442e-38 -2.421832e-04 -2.535072e-04 -2.651914e-04
## ASV8823     -3.083163e-38 -1.926707e-04 -2.016960e-04 -2.110404e-04
## ASV1379      4.307029e-38  2.682660e-04  2.807871e-04  2.937494e-04
## ASV3259     -4.307029e-38 -2.682660e-04 -2.807659e-04 -2.937264e-04
## ASV18748    -2.516290e-40  5.358788e-07  6.188262e-07  7.574088e-07
## ASV3570      9.265570e-39  5.821350e-05  6.099739e-05  6.384047e-05
## ASV0790     -1.112853e-38 -5.917191e-05 -6.149310e-05 -6.382420e-05
## ASV5149     -3.967337e-38 -2.452704e-04 -2.567303e-04 -2.684885e-04
## ASV1730     -4.079650e-38 -2.531622e-04 -2.649017e-04 -2.770802e-04
## ASV3488     -3.569086e-39 -2.091876e-05 -2.182091e-05 -2.276232e-05
## ASV5486     -4.307029e-38 -2.736626e-04 -2.865885e-04 -3.001064e-04
## ASV1319      8.796519e-39  4.441138e-05  4.613950e-05  4.775209e-05
## ASV15328    -3.040027e-38 -1.887361e-04 -1.975018e-04 -2.065888e-04
## ASV5994      4.376886e-38  2.724649e-04  2.851265e-04  2.982794e-04
## ASV4992     -3.727257e-39 -2.199804e-05 -2.298550e-05 -2.398390e-05
## ASV1788     -4.942839e-38 -2.988260e-04 -3.123858e-04 -3.263515e-04
## ASV3264     -1.094285e-39 -3.826389e-06 -3.871103e-06 -3.894058e-06
## ASV4895      2.304876e-39  1.296494e-05  1.352914e-05  1.408196e-05
## ASV9218     -1.341633e-39 -5.197697e-06 -5.277566e-06 -5.356211e-06
## ASV0736     -3.896382e-40 -5.372918e-06 -5.755406e-06 -6.173760e-06
## ASV0916      3.040027e-38  1.887360e-04  1.974657e-04  2.065496e-04
## ASV15761    -3.040027e-38 -1.887360e-04 -1.974509e-04 -2.065335e-04
## ASV4191      3.856746e-38  2.356273e-04  2.464337e-04  2.575757e-04
## ASV3268     -8.218848e-39 -4.852314e-05 -5.070820e-05 -5.291050e-05
## ASV15321    -4.457664e-39 -3.042370e-05 -3.191186e-05 -3.352344e-05
## ASV0708     -2.983608e-38 -1.881266e-04 -1.969934e-04 -2.062095e-04
## ASV4100      4.016963e-39  2.248101e-05  2.350198e-05  2.445891e-05
## ASV1627      2.603563e-38  1.526413e-04  1.593978e-04  1.662919e-04
## ASV7045     -2.671559e-38 -1.667436e-04 -1.746196e-04 -1.826950e-04
## ASV3271      7.978757e-39  4.109493e-05  4.264479e-05  4.420384e-05
## ASV6200     -4.478342e-39 -2.890118e-05 -3.029555e-05 -3.175110e-05
## ASV2727     -3.060995e-38 -1.962402e-04 -2.056570e-04 -2.154359e-04
## ASV3523     -4.219612e-38 -2.609672e-04 -2.731953e-04 -2.857142e-04
## ASV2259      2.832814e-38  1.760919e-04  1.842892e-04  1.927814e-04
## ASV0181      4.209740e-38  2.590859e-04  2.710705e-04  2.834265e-04
## ASV1680      8.363405e-38  5.184930e-04  5.426521e-04  5.675797e-04
## ASV0176      8.920378e-39  5.302650e-05  5.543215e-05  5.785994e-05
## ASV10458    -3.040027e-38 -1.893357e-04 -1.981811e-04 -2.073317e-04
## ASV10658    -3.040027e-38 -1.893357e-04 -1.981661e-04 -2.073155e-04
## ASV16807    -3.040027e-38 -1.893357e-04 -1.981512e-04 -2.072992e-04
## ASV2113     -3.040027e-38 -1.893357e-04 -1.981362e-04 -2.072830e-04
## ASV2403      3.158448e-38  1.944613e-04  2.034296e-04  2.127019e-04
## ASV2484     -3.040027e-38 -1.893357e-04 -1.981301e-04 -2.072763e-04
## ASV8876     -3.040027e-38 -1.893357e-04 -1.981152e-04 -2.072600e-04
## ASV0386      4.388575e-38  2.765242e-04  2.894985e-04  3.030290e-04
## ASV0351      1.266892e-38  7.673294e-05  8.016972e-05  8.375475e-05
## ASV4942     -1.743414e-38 -1.080154e-04 -1.129479e-04 -1.181334e-04
## ASV5128     -1.323837e-38 -8.351455e-05 -8.738527e-05 -9.146967e-05
## ASV3496      1.425058e-38  9.317875e-05  9.774039e-05  1.024865e-04
## ASV3329      4.379282e-38  2.752929e-04  2.882441e-04  3.016823e-04
## ASV7878     -3.040027e-38 -1.887802e-04 -1.975017e-04 -2.065870e-04
## ASV8251     -1.154975e-38 -7.172883e-05 -7.503126e-05 -7.848119e-05
## ASV15958    -9.834646e-39 -6.191819e-05 -6.476432e-05 -6.778501e-05
## ASV7972     -4.307029e-38 -2.695357e-04 -2.821526e-04 -2.952441e-04
## ASV2088      4.307029e-38  2.695357e-04  2.821312e-04  2.952209e-04
## ASV3054     -2.025664e-38 -1.268731e-04 -1.327936e-04 -1.389577e-04
## ASV4494     -4.307029e-38 -2.695356e-04 -2.821014e-04 -2.951884e-04
## ASV0087     -8.251085e-38 -5.114485e-04 -5.351609e-04 -5.597362e-04
## ASV1614     -3.377745e-38 -2.090453e-04 -2.188218e-04 -2.288547e-04
## ASV3037     -1.860880e-38 -1.156838e-04 -1.211680e-04 -1.267522e-04
## ASV6615     -4.386457e-39 -3.000699e-05 -3.150718e-05 -3.309968e-05
## ASV1027      1.283109e-38  7.861818e-05  8.221562e-05  8.594156e-05
## ASV2754     -7.320234e-39 -4.861193e-05 -5.095812e-05 -5.346544e-05
## ASV0536     -5.846963e-39 -3.803016e-05 -3.986596e-05 -4.178872e-05
## ASV2318     -1.270832e-38 -8.081064e-05 -8.461129e-05 -8.860534e-05
## ASV5954      2.687102e-38  1.615541e-04  1.688707e-04  1.763737e-04
## ASV9028      1.812002e-38  1.131930e-04  1.184980e-04  1.239845e-04
## ASV6600     -3.040027e-38 -1.913244e-04 -2.002746e-04 -2.096233e-04
## ASV1923     -8.299008e-39 -5.060743e-05 -5.289302e-05 -5.527586e-05
## ASV4034     -5.193104e-39 -3.659515e-05 -3.837241e-05 -4.036075e-05
## ASV9933     -3.040027e-38 -1.913244e-04 -2.002536e-04 -2.096002e-04
## ASV1575      6.183101e-39  3.617776e-05  3.777376e-05  3.940393e-05
## ASV7812     -5.242834e-38 -3.255313e-04 -3.407992e-04 -3.564817e-04
## ASV0515      3.451993e-38  2.102899e-04  2.198116e-04  2.297123e-04
## ASV1149     -2.771597e-39 -2.305398e-05 -2.433826e-05 -2.575517e-05
## ASV3791      1.368968e-38  8.737430e-05  9.144770e-05  9.577789e-05
## ASV4065     -4.893616e-38 -3.045635e-04 -3.186988e-04 -3.333920e-04
## ASV10631    -2.299719e-39 -1.694528e-05 -1.778915e-05 -1.874780e-05
## ASV2359     -5.026041e-38 -3.022999e-04 -3.159939e-04 -3.300455e-04
## ASV3206     -3.040027e-38 -1.894545e-04 -1.983158e-04 -2.074803e-04
## ASV4415      2.472808e-38  1.542281e-04  1.614286e-04  1.688886e-04
## ASV4467     -2.202237e-38 -1.359572e-04 -1.422701e-04 -1.487774e-04
## ASV5598      3.638726e-38  2.316995e-04  2.426944e-04  2.541673e-04
## ASV5910     -3.348159e-38 -2.089999e-04 -2.187602e-04 -2.288859e-04
## ASV9494     -3.040027e-38 -1.894545e-04 -1.982750e-04 -2.074360e-04
## ASV6548     -2.491846e-38 -1.547976e-04 -1.619703e-04 -1.694279e-04
## ASV8669     -3.040027e-38 -1.894545e-04 -1.982481e-04 -2.074067e-04
## ASV0674      1.962709e-38  1.182687e-04  1.236345e-04  1.291353e-04
## ASV0061     -7.184781e-39 -5.551956e-05 -5.845965e-05 -6.169586e-05
## ASV0310     -1.948525e-38 -1.177283e-04 -1.229651e-04 -1.284775e-04
## ASV0582      6.454997e-39  3.657020e-05  3.815041e-05  3.973084e-05
## ASV0739      5.695466e-38  3.584909e-04  3.753339e-04  3.928513e-04
## ASV1557      2.335143e-38  1.493822e-04  1.565115e-04  1.639436e-04
## ASV0146      5.568066e-38  3.363176e-04  3.517397e-04  3.674502e-04
## ASV3832      5.599303e-38  3.429288e-04  3.587704e-04  3.750328e-04
## ASV0734      1.204715e-38  7.634825e-05  8.001990e-05  8.377865e-05
## ASV3036     -3.978679e-38 -2.504909e-04 -2.623008e-04 -2.745547e-04
## ASV0240      1.104614e-38  6.756115e-05  7.068404e-05  7.388423e-05
## ASV2513     -6.119988e-38 -3.768651e-04 -3.944353e-04 -4.124281e-04
## ASV1118     -1.556208e-38 -9.982888e-05 -1.046814e-04 -1.096613e-04
## ASV7286     -3.040027e-38 -1.889275e-04 -1.977866e-04 -2.068996e-04
## ASV1077      4.127605e-38  2.528604e-04  2.645439e-04  2.765451e-04
## ASV1255     -3.040027e-38 -1.889274e-04 -1.977543e-04 -2.068648e-04
## ASV1794     -1.742954e-39 -1.142341e-05 -1.193942e-05 -1.251656e-05
## ASV2439     -3.040027e-38 -1.889274e-04 -1.977400e-04 -2.068493e-04
## ASV2467     -3.040027e-38 -1.889274e-04 -1.977251e-04 -2.068331e-04
## ASV3346     -3.040027e-38 -1.889274e-04 -1.977102e-04 -2.068170e-04
## ASV3973     -3.040027e-38 -1.889274e-04 -1.976954e-04 -2.068008e-04
## ASV4521      1.367489e-38  8.362637e-05  8.748065e-05  9.143482e-05
## ASV1909     -3.534639e-38 -2.240269e-04 -2.346255e-04 -2.456600e-04
## ASV3855     -2.745899e-38 -1.695082e-04 -1.773081e-04 -1.854133e-04
## ASV0810      3.612395e-38  2.257866e-04  2.363437e-04  2.472942e-04
## ASV1765      4.274591e-38  2.690489e-04  2.816640e-04  2.948134e-04
## ASV0763      2.361034e-38  1.465670e-04  1.533222e-04  1.603741e-04
## ASV0302     -2.606538e-38 -1.600310e-04 -1.673558e-04 -1.749588e-04
## ASV2643     -3.633385e-38 -2.182928e-04 -2.283087e-04 -2.384619e-04
## ASV0440      1.322707e-38  8.422834e-05  8.815537e-05  9.230920e-05
## ASV4899     -2.544501e-38 -1.536627e-04 -1.606494e-04 -1.678162e-04
## ASV0287     -1.478757e-38 -9.292120e-05 -9.725620e-05 -1.017919e-04
## ASV3220      1.836803e-38  1.161241e-04  1.216499e-04  1.273510e-04
## ASV1007     -1.121338e-38 -6.728679e-05 -7.028801e-05 -7.339891e-05
## ASV2929     -7.419660e-39 -4.311374e-05 -4.497698e-05 -4.689418e-05
## ASV1496     -2.526874e-38 -1.600943e-04 -1.675796e-04 -1.754554e-04
## ASV4975      1.115656e-38  7.003101e-05  7.330521e-05  7.671261e-05
## ASV4392     -2.125475e-39 -1.000587e-05 -1.045338e-05 -1.076795e-05
## ASV4653     -3.040027e-38 -1.908378e-04 -1.997428e-04 -2.090413e-04
## ASV0230     -1.538055e-38 -9.753220e-05 -1.021734e-04 -1.069805e-04
## ASV0840      2.197581e-38  1.377267e-04  1.441258e-04  1.508233e-04
## ASV4132     -6.325908e-39 -4.100634e-05 -4.293526e-05 -4.499975e-05
## ASV3344      2.357074e-38  1.439519e-04  1.505178e-04  1.573191e-04
## ASV12096    -3.070205e-38 -1.933406e-04 -2.025245e-04 -2.119806e-04
## ASV1550      1.126883e-38  6.518792e-05  6.805987e-05  7.094823e-05
## ASV3542     -4.516231e-38 -2.865426e-04 -3.001232e-04 -3.142356e-04
## ASV8795     -1.761531e-38 -1.110229e-04 -1.162286e-04 -1.216610e-04
## ASV2532     -7.746705e-40 -5.875546e-06 -6.179098e-06 -6.519181e-06
## ASV3087      7.689922e-39  4.620340e-05  4.831318e-05  5.045706e-05
## ASV9476     -1.761531e-38 -1.110229e-04 -1.162225e-04 -1.216543e-04
## ASV13721    -1.761531e-38 -1.110229e-04 -1.162137e-04 -1.216446e-04
## ASV3842      3.012661e-38  1.834955e-04  1.919608e-04  2.006115e-04
## ASV1663      5.419548e-38  3.303744e-04  3.454982e-04  3.610814e-04
## ASV0432      1.275744e-38  7.761027e-05  8.122731e-05  8.488460e-05
## ASV4356      5.254926e-38  3.261442e-04  3.413207e-04  3.570195e-04
## ASV4524      1.227914e-38  7.898520e-05  8.277556e-05  8.672685e-05
## ASV0169     -2.531687e-38 -1.605636e-04 -1.682030e-04 -1.761170e-04
## ASV0368     -2.177830e-38 -1.380267e-04 -1.445869e-04 -1.513839e-04
## ASV2603     -3.159731e-53  4.204211e-08  6.910920e-08  7.149094e-08
## ASV3777      2.922679e-38  1.824661e-04  1.909655e-04  1.998014e-04
## ASV3978      2.569218e-38  1.586095e-04  1.659648e-04  1.735499e-04
## ASV0413     -2.056321e-38 -1.302726e-04 -1.364414e-04 -1.428516e-04
## ASV0997      2.545339e-53 -4.203807e-08 -4.481703e-08 -4.514101e-08
## ASV1195      2.545339e-53 -4.203875e-08 -4.481233e-08 -4.514043e-08
## ASV2522     -1.383160e-38 -8.592150e-05 -8.992256e-05 -9.406205e-05
## ASV4733      2.505383e-38  1.568063e-04  1.641391e-04  1.717519e-04
## ASV1063      4.307029e-38  2.743104e-04  2.873538e-04  3.009411e-04
## ASV0612     -5.552434e-38 -3.502166e-04 -3.666972e-04 -3.838619e-04
## ASV1903     -4.307029e-38 -2.743104e-04 -2.873057e-04 -3.008885e-04
## ASV3576     -1.197723e-38 -7.951576e-05 -8.341458e-05 -8.752376e-05
## ASV4285     -3.095438e-38 -1.955813e-04 -2.048959e-04 -2.144997e-04
## ASV3406     -1.626288e-38 -1.018944e-04 -1.066345e-04 -1.115894e-04
## ASV2379     -3.192772e-38 -1.902829e-04 -1.989844e-04 -2.077427e-04
## ASV0528      3.816776e-38  2.392023e-04  2.504446e-04  2.620815e-04
## ASV6190     -4.716481e-39 -3.097497e-05 -3.242179e-05 -3.399961e-05
## ASV1537     -6.867209e-40 -2.662551e-06 -2.751168e-06 -2.792222e-06
## ASV16780    -3.435590e-38 -2.129777e-04 -2.229593e-04 -2.332043e-04
## ASV0477      8.478532e-38  5.287614e-04  5.534110e-04  5.789935e-04
## ASV1499      1.818570e-38  1.203455e-04  1.261418e-04  1.323253e-04
## ASV14736     1.488083e-38  9.183241e-05  9.611140e-05  1.005077e-04
## ASV0179     -1.208851e-38 -7.620096e-05 -7.975793e-05 -8.348480e-05
## ASV3153      2.739063e-40  6.048219e-06  6.366185e-06  6.883729e-06
## ASV0266      3.932887e-38  2.468574e-04  2.584722e-04  2.705097e-04
## ASV0761      5.930933e-38  3.661430e-04  3.832390e-04  4.007695e-04
## ASV0269     -5.082833e-39 -3.553890e-05 -3.726639e-05 -3.918982e-05
## ASV7259     -1.025253e-38 -6.873749e-05 -7.215260e-05 -7.572973e-05
## ASV2067     -1.283911e-38 -7.773780e-05 -8.132201e-05 -8.496447e-05
## ASV2985     -3.473450e-38 -2.169699e-04 -2.271261e-04 -2.376335e-04
## ASV0975     -5.235299e-38 -3.287436e-04 -3.441549e-04 -3.601812e-04
## ASV2240      3.222151e-38  1.962929e-04  2.052263e-04  2.144798e-04
## ASV2297      1.107632e-38  6.416032e-05  6.701539e-05  6.986726e-05
## ASV2657      1.373581e-38  8.274745e-05  8.641838e-05  9.026708e-05
## ASV3784      5.617299e-53  2.681556e-06  2.841049e-06  3.107771e-06
## ASV4333      6.319462e-53  2.681555e-06  2.840779e-06  3.107297e-06
## ASV5547      2.851122e-38  1.699012e-04  1.774719e-04  1.852833e-04
## ASV5813      1.148755e-38  6.884235e-05  7.199135e-05  7.517813e-05
## ASV8049      1.342177e-38  8.228931e-05  8.613203e-05  9.004503e-05
## ASV8661     -6.319462e-53 -2.681547e-06 -2.849259e-06 -3.116111e-06
## ASV9510      1.574031e-38  9.621344e-05  1.006788e-04  1.052337e-04
## ASV1401      8.339445e-39  5.054721e-05  5.288269e-05  5.525579e-05
## ASV1417     -1.757340e-38 -1.016218e-04 -1.060072e-04 -1.105069e-04
## ASV2169      5.646140e-38  3.506219e-04  3.668805e-04  3.837656e-04
## ASV5354     -5.617299e-53 -2.681521e-06 -2.859562e-06 -3.127051e-06
## ASV5379     -6.056151e-53 -2.681520e-06 -2.859261e-06 -3.126576e-06
## ASV6078     -6.319462e-53 -2.681519e-06 -2.858960e-06 -3.126101e-06
## ASV6417      3.497862e-38  2.145508e-04  2.244963e-04  2.346929e-04
## ASV8304      2.578021e-38  1.558447e-04  1.629020e-04  1.701831e-04
## ASV8766     -5.617299e-53 -2.681528e-06 -2.876631e-06 -3.145002e-06
## ASV10861     1.088676e-38  6.511431e-05  6.809094e-05  7.109751e-05
## ASV2057      5.574988e-38  3.466268e-04  3.627652e-04  3.794810e-04
## ASV4499      2.060167e-38  1.222621e-04  1.277211e-04  1.333089e-04
## ASV7415      6.084608e-39  3.840131e-05  4.018584e-05  4.206144e-05
## ASV2475     -2.377376e-38 -1.485477e-04 -1.554706e-04 -1.626740e-04
## ASV3517     -3.830651e-38 -2.426190e-04 -2.541041e-04 -2.660502e-04
## ASV1864      2.671838e-38  1.634467e-04  1.709256e-04  1.786618e-04
## ASV2756      3.040027e-38  1.883586e-04  1.971904e-04  2.062460e-04
## ASV0778      3.040027e-38  1.883586e-04  1.971754e-04  2.062300e-04
## ASV3201      6.133857e-39  4.251226e-05  4.462056e-05  4.690409e-05
## ASV3358      3.040027e-38  1.883586e-04  1.971627e-04  2.062163e-04
## ASV5681     -3.040027e-38 -1.883586e-04 -1.971478e-04 -2.062002e-04
## ASV7256      1.456183e-38  9.122436e-05  9.542678e-05  9.986754e-05
## ASV1704     -3.126444e-38 -1.927072e-04 -2.016546e-04 -2.108569e-04
## ASV4445      5.066048e-38  3.041588e-04  3.178662e-04  3.319707e-04
## ASV8649     -3.040027e-38 -1.883585e-04 -1.971172e-04 -2.061673e-04
## ASV0597      3.161529e-38  1.958003e-04  2.048849e-04  2.142866e-04
## ASV0861      4.058681e-38  2.494954e-04  2.610095e-04  2.728904e-04
## ASV2423      4.903294e-38  3.025311e-04  3.165617e-04  3.310244e-04
## ASV1548      2.491950e-38  1.481810e-04  1.547863e-04  1.615726e-04
## ASV2564      4.121197e-38  2.521173e-04  2.636382e-04  2.755653e-04
## ASV2999      6.880709e-38  4.194366e-04  4.386481e-04  4.584310e-04
## ASV4543     -2.380519e-38 -1.506816e-04 -1.577962e-04 -1.652112e-04
## ASV8452      2.390541e-38  1.441865e-04  1.507003e-04  1.574146e-04
## ASV17287    -4.316807e-39 -2.982243e-05 -3.136348e-05 -3.296875e-05
## ASV3503     -3.040027e-38 -1.927941e-04 -2.019007e-04 -2.114054e-04
## ASV4727     -4.615837e-39 -3.273881e-05 -3.442745e-05 -3.622600e-05
## ASV5995     -2.590448e-38 -1.640652e-04 -1.717925e-04 -1.798681e-04
## ASV1665     -8.303436e-39 -5.261825e-05 -5.501886e-05 -5.760279e-05
## ASV2690     -3.943560e-38 -2.458772e-04 -2.573936e-04 -2.692929e-04
## ASV2823     -3.362732e-39 -2.013372e-05 -2.099439e-05 -2.192217e-05
## ASV5241     -5.271523e-38 -3.287219e-04 -3.441766e-04 -3.600854e-04
## ASV5473     -1.473488e-38 -9.420544e-05 -9.870138e-05 -1.033873e-04
## ASV2785      6.525124e-39  4.245505e-05  4.450373e-05  4.665149e-05
## ASV6645     -2.246124e-38 -1.389753e-04 -1.455140e-04 -1.521846e-04
## ASV0562      9.603473e-39  5.658020e-05  5.906063e-05  6.161178e-05
## ASV1163      8.953873e-39  5.670655e-05  5.937215e-05  6.215939e-05
## ASV1825      1.754274e-38  1.073738e-04  1.123263e-04  1.174105e-04
## ASV3795      3.835534e-38  2.369376e-04  2.478590e-04  2.592033e-04
## ASV3869     -8.068118e-39 -5.284172e-05 -5.536171e-05 -5.805357e-05
## ASV4330      2.938276e-38  1.825280e-04  1.910090e-04  1.998000e-04
## ASV6754      1.117095e-38  6.937410e-05  7.261327e-05  7.595290e-05
## ASV4598     -1.263892e-52 -1.673084e-06 -1.792657e-06 -1.964419e-06
## ASV2100      2.317000e-38  1.405966e-04  1.469536e-04  1.535480e-04
## ASV3518      1.152372e-38  6.986669e-05  7.305609e-05  7.632675e-05
## ASV3823      4.697848e-38  2.889604e-04  3.022847e-04  3.160522e-04
## ASV7357      2.864235e-38  1.772832e-04  1.854563e-04  1.939584e-04
## ASV7403     -3.675345e-38 -2.265246e-04 -2.370863e-04 -2.479105e-04
## ASV2934     -1.795432e-39 -9.825731e-06 -1.024419e-05 -1.064685e-05
## ASV5277     -1.913656e-38 -1.178885e-04 -1.234265e-04 -1.290577e-04
## ASV0281     -5.619807e-38 -3.473925e-04 -3.635454e-04 -3.801993e-04
## ASV11181    -2.001933e-38 -1.286404e-04 -1.347825e-04 -1.412177e-04
## ASV0254     -8.439049e-39 -4.575259e-05 -4.769365e-05 -4.954325e-05
## ASV0201     -9.079864e-39 -5.970264e-05 -6.255079e-05 -6.560398e-05
## ASV3656     -2.285292e-38 -1.482619e-04 -1.553453e-04 -1.628276e-04
## ASV7994     -4.302881e-38 -2.682037e-04 -2.807384e-04 -2.937117e-04
## ASV3584     -1.530725e-38 -8.771091e-05 -9.169881e-05 -9.555708e-05
## ASV2157      4.525094e-38  2.764732e-04  2.890633e-04  3.021358e-04
## ASV2935     -5.673941e-39 -3.546228e-05 -3.713342e-05 -3.885551e-05
## ASV9024     -4.094669e-38 -2.515052e-04 -2.632121e-04 -2.751843e-04
## ASV7711      2.358290e-38  1.500354e-04  1.571505e-04  1.645713e-04
## ASV11330    -3.040027e-38 -1.903760e-04 -1.992445e-04 -2.084969e-04
## ASV1875      2.698005e-38  1.678230e-04  1.756431e-04  1.837458e-04
## ASV5861      1.969454e-38  1.254338e-04  1.313962e-04  1.376058e-04
## ASV11562     1.682179e-39  1.091079e-05  1.149189e-05  1.204504e-05
## ASV18559    -3.040027e-38 -1.903760e-04 -1.992397e-04 -2.084915e-04
## ASV4384      2.894791e-38  1.839432e-04  1.926601e-04  2.017450e-04
## ASV1302      6.249360e-38  3.774185e-04  3.944913e-04  4.121201e-04
## ASV4673     -3.963832e-38 -2.497934e-04 -2.615870e-04 -2.738128e-04
## ASV1956      7.443625e-39  4.250821e-05  4.414550e-05  4.600040e-05
## ASV3286      2.736242e-38  1.740384e-04  1.822949e-04  1.908981e-04
## ASV4866     -4.307029e-38 -2.730910e-04 -2.859896e-04 -2.994501e-04
## ASV3129     -2.128138e-38 -1.341073e-04 -1.404031e-04 -1.469693e-04
## ASV4104      4.966319e-38  3.087393e-04  3.231119e-04  3.379973e-04
## ASV8983      4.184759e-40  2.627695e-06  2.636635e-06  2.759437e-06
## ASV2201      1.971777e-38  1.185703e-04  1.239151e-04  1.294181e-04
## ASV3055      1.396143e-38  8.143057e-05  8.501051e-05  8.865840e-05
## ASV0534     -6.525738e-38 -4.027769e-04 -4.213758e-04 -4.406330e-04
## ASV1019      1.676070e-39  1.316611e-05  1.389055e-05  1.467442e-05
## ASV18482    -3.040027e-38 -1.873584e-04 -1.960428e-04 -2.049911e-04
## ASV2694      1.076664e-38  6.297351e-05  6.567858e-05  6.850343e-05
## ASV3412     -9.750170e-39 -5.785566e-05 -6.046107e-05 -6.310247e-05
## ASV4174     -3.040027e-38 -1.873584e-04 -1.960244e-04 -2.049713e-04
## ASV4281     -3.040027e-38 -1.873584e-04 -1.960097e-04 -2.049555e-04
## ASV4949      3.461644e-38  2.105806e-04  2.201724e-04  2.300809e-04
## ASV5881      1.609510e-38  9.887132e-05  1.033845e-04  1.080832e-04
## ASV6299     -1.377015e-38 -8.329750e-05 -8.706562e-05 -9.095657e-05
## ASV0676      3.515408e-38  2.153146e-04  2.251425e-04  2.353515e-04
## ASV1066     -2.409096e-38 -1.468997e-04 -1.536397e-04 -1.605681e-04
## ASV1300     -2.045763e-38 -1.255311e-04 -1.313396e-04 -1.373043e-04
## ASV6455      9.817844e-39  6.113570e-05  6.400646e-05  6.696206e-05
## ASV3455     -3.040027e-38 -1.873584e-04 -1.960054e-04 -2.049507e-04
## ASV6531     -3.040027e-38 -1.873584e-04 -1.959907e-04 -2.049349e-04
## ASV0490      6.166980e-38  3.748416e-04  3.922913e-04  4.099512e-04
## ASV2588      2.239553e-39  1.979382e-05  2.084299e-05  2.210037e-05
## ASV5364      1.922499e-38  1.180640e-04  1.234776e-04  1.290881e-04
## ASV0981     -4.146777e-38 -2.610009e-04 -2.732745e-04 -2.860322e-04
## ASV1563     -8.506239e-39 -5.358210e-05 -5.610453e-05 -5.872911e-05
## ASV0376     -3.978714e-38 -2.504242e-04 -2.622005e-04 -2.744382e-04
## ASV7308     -7.021624e-53 -1.192073e-06 -1.312174e-06 -1.440031e-06
## ASV4817      7.003246e-39  4.058565e-05  4.232463e-05  4.411955e-05
## ASV8716     -4.519475e-38 -2.667619e-04 -2.790389e-04 -2.911944e-04
## ASV1849      5.671268e-38  3.400970e-04  3.553524e-04  3.710876e-04
## ASV9423     -4.263563e-38 -2.618940e-04 -2.741271e-04 -2.866018e-04
## ASV7690      1.464947e-39  9.742676e-06  1.027286e-05  1.077780e-05
## ASV4901      2.303209e-38  1.444036e-04  1.511733e-04  1.582000e-04
## ASV1830     -6.285775e-39 -4.546274e-05 -4.777712e-05 -5.030776e-05
## ASV2316     -3.307379e-38 -1.953075e-04 -2.044091e-04 -2.133314e-04
## ASV0693      4.634568e-38  2.895710e-04  3.030600e-04  3.170948e-04
## ASV1243     -3.231771e-39 -1.625516e-05 -1.702574e-05 -1.761577e-05
## ASV3867      1.200127e-38  7.608015e-05  7.971183e-05  8.346067e-05
## ASV7932      2.631194e-38  1.641844e-04  1.718427e-04  1.797876e-04
## ASV12608     1.835579e-38  1.182940e-04  1.239700e-04  1.299011e-04
## ASV1661      2.779380e-38  1.720062e-04  1.800455e-04  1.883001e-04
## ASV3957      2.882247e-38  1.807181e-04  1.891418e-04  1.979384e-04
## ASV0830     -4.619947e-38 -2.854054e-04 -2.985874e-04 -3.122533e-04
## ASV2078      5.209910e-38  3.238818e-04  3.389656e-04  3.545904e-04
## ASV13932    -3.040027e-38 -1.908956e-04 -1.998331e-04 -2.091406e-04
## ASV5300     -3.040027e-38 -1.908956e-04 -1.998180e-04 -2.091241e-04
## ASV1014     -1.663817e-38 -1.027899e-04 -1.075432e-04 -1.124611e-04
## ASV13059    -8.628727e-39 -5.855153e-05 -6.152166e-05 -6.460745e-05
## ASV4340      6.468906e-39  3.905374e-05  4.075089e-05  4.257039e-05
## ASV5591     -5.155192e-38 -3.181510e-04 -3.330152e-04 -3.482410e-04
## ASV6040     -4.104540e-38 -2.542931e-04 -2.661674e-04 -2.783855e-04
## ASV3904     -1.654864e-38 -1.050748e-04 -1.100335e-04 -1.152175e-04
## ASV2267     -4.739763e-39 -2.972712e-05 -3.109801e-05 -3.254094e-05
## ASV0573     -3.943174e-38 -2.386682e-04 -2.494689e-04 -2.606319e-04
## ASV0851     -4.140501e-38 -2.567189e-04 -2.685510e-04 -2.808799e-04
## ASV7805      1.250375e-38  8.007852e-05  8.388224e-05  8.786956e-05
## ASV3379      5.637508e-38  3.439529e-04  3.596006e-04  3.758394e-04
## ASV0825      2.421932e-38  1.548923e-04  1.623065e-04  1.700071e-04
## ASV2461      2.925304e-38  1.798515e-04  1.881066e-04  1.966712e-04
## ASV2783      4.049980e-38  2.507395e-04  2.624341e-04  2.744731e-04
## ASV0925      4.601356e-38  2.813424e-04  2.942269e-04  3.075364e-04
## ASV7023     -4.265189e-38 -2.673558e-04 -2.799002e-04 -2.929111e-04
## ASV5319      7.620300e-39  4.853832e-05  5.083472e-05  5.323111e-05
## ASV3213      2.656255e-38  1.668734e-04  1.746892e-04  1.828243e-04
## ASV3748     -6.185416e-39 -4.119452e-05 -4.325325e-05 -4.539423e-05
## ASV5491     -9.286837e-39 -6.057396e-05 -6.352451e-05 -6.660451e-05
## ASV7931      1.679205e-38  1.051736e-04  1.100627e-04  1.151692e-04
## ASV12767    -3.040027e-38 -1.916526e-04 -2.006726e-04 -2.100598e-04
## ASV6389      3.072072e-38  1.931572e-04  2.022568e-04  2.116910e-04
## ASV14867    -3.040027e-38 -1.916526e-04 -2.006571e-04 -2.100429e-04
## ASV5105      1.745172e-38  1.114350e-04  1.167591e-04  1.222906e-04
## ASV15927    -3.040027e-38 -1.910954e-04 -2.000476e-04 -2.093741e-04
## ASV2004      1.066040e-38  6.579782e-05  6.879071e-05  7.193700e-05
## ASV5554      6.498068e-40 -2.894872e-06 -3.293912e-06 -3.800176e-06
## ASV10929    -2.126941e-38 -1.337494e-04 -1.399882e-04 -1.465187e-04
## ASV12778    -1.055950e-38 -6.603871e-05 -6.909643e-05 -7.230028e-05
## ASV14006    -3.040027e-38 -1.910954e-04 -2.000139e-04 -2.093370e-04
## ASV1603      2.961751e-38  1.867367e-04  1.955019e-04  2.046465e-04
## ASV11948     1.599421e-38  9.665367e-05  1.010360e-04  1.055455e-04
## ASV12912    -3.040027e-38 -1.917999e-04 -2.008451e-04 -2.102477e-04
## ASV13147    -3.040027e-38 -1.917999e-04 -2.008298e-04 -2.102310e-04
## ASV14761    -3.040027e-38 -1.917999e-04 -2.008145e-04 -2.102143e-04
## ASV8521      2.543542e-38  1.542258e-04  1.612770e-04  1.685027e-04
## ASV8581     -3.040027e-38 -1.917999e-04 -2.008044e-04 -2.102032e-04
## ASV9875     -4.820070e-39 -3.253078e-05 -3.414615e-05 -3.585534e-05
## ASV9986      1.996192e-38  1.270076e-04  1.330085e-04  1.392857e-04
## ASV2376      3.592571e-38  2.229117e-04  2.332582e-04  2.439825e-04
## ASV17535    -3.040027e-38 -1.917999e-04 -2.007937e-04 -2.101914e-04
## ASV14330    -3.040027e-38 -1.861571e-04 -1.946604e-04 -2.034824e-04
## ASV1333     -6.464688e-38 -3.868483e-04 -4.041529e-04 -4.220150e-04
## ASV2498      1.399899e-38  9.132833e-05  9.577494e-05  1.004046e-04
## ASV6352     -1.271937e-38 -7.623985e-05 -7.963501e-05 -8.315930e-05
## ASV8601     -1.560724e-38 -9.525907e-05 -9.957293e-05 -1.040688e-04
## ASV9776     -1.201910e-38 -7.137216e-05 -7.448998e-05 -7.774732e-05
## ASV1916      2.695835e-38  1.650723e-04  1.725745e-04  1.804001e-04
## ASV1555      3.012867e-39  2.055543e-05  2.155867e-05  2.264650e-05
## ASV2499      4.118412e-38  2.590629e-04  2.711912e-04  2.838422e-04
## ASV0703      3.417865e-38  2.136636e-04  2.235686e-04  2.339328e-04
## ASV2047      4.569240e-38  2.833889e-04  2.967019e-04  3.103434e-04
## ASV5492     -3.040027e-38 -1.923284e-04 -2.013906e-04 -2.108471e-04
## ASV6549     -2.922461e-39 -1.951263e-05 -2.045707e-05 -2.147244e-05
## ASV7757     -1.023691e-38 -6.792423e-05 -7.124975e-05 -7.475915e-05
## ASV0173      2.106487e-53 -1.430885e-06 -1.563536e-06 -1.710517e-06
## ASV1248     -9.723342e-39 -5.858917e-05 -6.122150e-05 -6.394305e-05
## ASV6502     -2.106487e-53  1.430888e-06  1.567534e-06  1.714836e-06
## ASV9844     -2.106487e-53  1.430889e-06  1.567302e-06  1.714575e-06
## ASV3903      1.930258e-38  1.224721e-04  1.282841e-04  1.343247e-04
## ASV8199     -9.128111e-53  1.430890e-06  1.559470e-06  1.706024e-06
## ASV3309     -1.497663e-39 -8.716180e-06 -9.095356e-06 -9.481619e-06
## ASV5826     -4.227710e-39 -2.809422e-05 -2.943239e-05 -3.088031e-05
## ASV1480     -4.064236e-38 -2.572699e-04 -2.694254e-04 -2.820821e-04
## ASV3090      8.921726e-39  5.486483e-05  5.739845e-05  6.001150e-05
## ASV0758     -2.629440e-38 -1.572807e-04 -1.644161e-04 -1.716826e-04
## ASV0811     -7.891690e-39 -4.750576e-05 -4.956644e-05 -5.176943e-05
## ASV2653      1.990638e-38  1.273400e-04  1.334063e-04  1.397370e-04
## ASV0978      2.050744e-38  1.315675e-04  1.379013e-04  1.444609e-04
## ASV6640     -4.293631e-38 -2.673489e-04 -2.798504e-04 -2.927682e-04
## ASV3423     -1.489408e-39 -1.190960e-05 -1.253818e-05 -1.325844e-05
## ASV0617      4.515055e-38  2.688460e-04  2.812933e-04  2.936747e-04
## ASV14947    -4.307029e-38 -2.700078e-04 -2.826789e-04 -2.958176e-04
## ASV18367    -2.279611e-38 -1.474061e-04 -1.544992e-04 -1.619066e-04
## ASV4574      3.460524e-38  2.077722e-04  2.171796e-04  2.268073e-04
## ASV10514    -2.275386e-38 -1.439615e-04 -1.507744e-04 -1.578509e-04
## ASV11779    -1.017620e-38 -7.115572e-05 -7.478736e-05 -7.863220e-05
## ASV7528     -3.681356e-38 -2.331148e-04 -2.441242e-04 -2.555861e-04
## ASV13153    -2.102070e-38 -1.340028e-04 -1.403497e-04 -1.469862e-04
## ASV7858     -1.867022e-38 -1.190095e-04 -1.246355e-04 -1.305281e-04
## ASV8722      7.224469e-39  4.121891e-05  4.303585e-05  4.483056e-05
## ASV6585     -4.299129e-38 -2.695078e-04 -2.820834e-04 -2.951905e-04
## ASV3311     -3.911596e-38 -2.360605e-04 -2.466401e-04 -2.576270e-04
## ASV2469      2.834923e-40  3.668478e-06  3.891183e-06  4.160877e-06
## ASV11340    -1.930957e-38 -1.170539e-04 -1.224138e-04 -1.279030e-04
## ASV1718      3.713120e-39  2.219162e-05  2.317936e-05  2.419817e-05
## ASV2117     -4.252638e-38 -2.673006e-04 -2.798353e-04 -2.928771e-04
## ASV8252     -3.040027e-38 -1.900898e-04 -1.989505e-04 -2.081753e-04
## ASV8533      6.014853e-39  3.735595e-05  3.910481e-05  4.090501e-05
## ASV9507      4.979750e-39  2.904895e-05  3.032677e-05  3.162541e-05
## ASV0706      2.094894e-38  1.347501e-04  1.411907e-04  1.479346e-04
## ASV10312    -3.040027e-38 -1.900898e-04 -1.989344e-04 -2.081575e-04
## ASV10696    -3.040027e-38 -1.900898e-04 -1.989194e-04 -2.081412e-04
## ASV11203    -3.040027e-38 -1.900898e-04 -1.989045e-04 -2.081248e-04
## ASV12147    -6.955153e-39 -4.533057e-05 -4.746037e-05 -4.975499e-05
## ASV4602     -1.531212e-39 -1.169241e-05 -1.227984e-05 -1.295966e-05
## ASV5568      1.386763e-39  9.790990e-06  1.034140e-05  1.087923e-05
## ASV6777      3.884789e-38  2.432217e-04  2.546186e-04  2.664409e-04
## ASV8749     -3.461286e-38 -2.144134e-04 -2.243383e-04 -2.346348e-04
## ASV4780      6.329642e-39  3.704349e-05  3.864167e-05  4.029911e-05
## ASV10116    -5.842740e-39 -3.607155e-05 -3.773513e-05 -3.946361e-05
## ASV2907      3.325350e-38  2.073596e-04  2.170021e-04  2.270277e-04
## ASV5165      4.196199e-38  2.689407e-04  2.817466e-04  2.951488e-04
## ASV6061      2.450198e-38  1.509999e-04  1.579597e-04  1.651698e-04
## ASV8082     -1.495458e-38 -9.358009e-05 -9.794880e-05 -1.024963e-04
## ASV7696     -1.520627e-38 -9.526004e-05 -9.974278e-05 -1.043790e-04
## ASV0550      3.310722e-39  1.920290e-05  2.013985e-05  2.100443e-05
## ASV7745      1.883305e-38  1.215187e-04  1.272937e-04  1.333870e-04
## ASV3607     -5.565427e-40 -2.692397e-06 -2.870538e-06 -2.964965e-06
## ASV3877     -3.040027e-38 -1.859760e-04 -1.946099e-04 -2.034280e-04
## ASV7667     -1.404587e-38 -8.486172e-05 -8.881232e-05 -9.278522e-05
## ASV9293     -1.115352e-38 -7.061379e-05 -7.405767e-05 -7.753529e-05
## ASV11653    -3.040027e-38 -1.859760e-04 -1.945843e-04 -2.034007e-04
## ASV12850     4.173417e-39  2.934525e-05  3.081898e-05  3.240380e-05
## ASV13104     6.083174e-39  3.542779e-05  3.692529e-05  3.849870e-05
## ASV14208    -3.040027e-38 -1.859760e-04 -1.945728e-04 -2.033885e-04
## ASV1552      2.661183e-38  1.703319e-04  1.784522e-04  1.869268e-04
## ASV2501      1.929824e-38  1.165097e-04  1.218363e-04  1.272768e-04
## ASV2893      3.675758e-38  2.306292e-04  2.413994e-04  2.526230e-04
## ASV3084      1.440920e-38  8.781109e-05  9.177463e-05  9.591578e-05
## ASV3599      1.944468e-38  1.180177e-04  1.234130e-04  1.289515e-04
## ASV3868     -3.040027e-38 -1.859760e-04 -1.945730e-04 -2.033891e-04
## ASV3917     -4.063152e-38 -2.502195e-04 -2.617966e-04 -2.737405e-04
## ASV5695      7.105051e-39  4.645896e-05  4.866788e-05  5.102526e-05
## ASV0131      4.806333e-39  2.534001e-05  2.643212e-05  2.742289e-05
## ASV2847      3.733878e-38  2.260448e-04  2.362493e-04  2.468228e-04
## ASV6875     -3.004690e-38 -1.855479e-04 -1.942221e-04 -2.031086e-04
## ASV1547     -6.256318e-38 -3.838487e-04 -4.015685e-04 -4.198110e-04
## ASV1501     -3.889959e-38 -2.410032e-04 -2.522380e-04 -2.638227e-04
## ASV3876      4.307029e-38  2.682652e-04  2.808253e-04  2.937909e-04
## ASV3456     -4.307029e-38 -2.682652e-04 -2.808040e-04 -2.937679e-04
## ASV1194      4.063904e-38  2.530032e-04  2.648038e-04  2.770226e-04
## ASV2135     -5.148054e-38 -3.235759e-04 -3.387600e-04 -3.545508e-04
## ASV1352      4.307029e-38  2.682652e-04  2.807453e-04  2.937041e-04
## ASV3208      4.892952e-38  3.051278e-04  3.193189e-04  3.340765e-04
## ASV1164     -8.881616e-42  2.315403e-06  2.353422e-06  2.576720e-06
## ASV3492      1.965333e-38  1.270837e-04  1.331667e-04  1.395557e-04
## ASV1601      2.373118e-38  1.476540e-04  1.545259e-04  1.616518e-04
## ASV5347     -3.102959e-38 -1.898687e-04 -1.985932e-04 -2.075920e-04
## ASV0293      2.284369e-38  1.425695e-04  1.491741e-04  1.560722e-04
## ASV1509      3.955336e-38  2.460291e-04  2.574817e-04  2.693465e-04
## ASV2801      5.911643e-39  3.596324e-05  3.754659e-05  3.923691e-05
## ASV2873     -8.888170e-39 -5.682793e-05 -5.952826e-05 -6.235588e-05
## ASV2162     -6.300125e-39 -3.856482e-05 -4.024332e-05 -4.206748e-05
## ASV0462      2.520726e-38  1.499902e-04  1.566383e-04  1.635211e-04
## ASV5367     -3.698323e-38 -2.322551e-04 -2.432479e-04 -2.545760e-04
## ASV2715      4.718652e-38  2.913497e-04  3.048250e-04  3.187649e-04
## ASV0371      5.916445e-38  3.582895e-04  3.748761e-04  3.916820e-04
## ASV8090     -4.017981e-38 -2.468750e-04 -2.583321e-04 -2.700853e-04
## ASV6320     -3.040027e-38 -1.918999e-04 -2.009150e-04 -2.103265e-04
## ASV2562      3.183314e-38  2.015163e-04  2.109771e-04  2.208834e-04
## ASV1505     -4.497269e-38 -2.829101e-04 -2.961594e-04 -3.099709e-04
## ASV4924     -3.514644e-38 -2.174022e-04 -2.275748e-04 -2.380036e-04
## ASV1437      3.899839e-38  2.427436e-04  2.541160e-04  2.658423e-04
## ASV3816     -3.289596e-39 -1.665658e-05 -1.735130e-05 -1.796610e-05
## ASV1969     -1.781194e-38 -1.166758e-04 -1.223983e-04 -1.283149e-04
## ASV3146      2.141451e-38  1.296606e-04  1.355519e-04  1.416216e-04
## ASV0321     -2.296600e-38 -1.401551e-04 -1.465833e-04 -1.532120e-04
## ASV1020      4.606201e-38  2.823986e-04  2.952382e-04  3.086392e-04
## ASV4138      2.717335e-39  1.939182e-05  2.029818e-05  2.135814e-05
## ASV0329     -2.484861e-38 -1.556872e-04 -1.629488e-04 -1.705129e-04
## ASV10647     4.261014e-39  2.781912e-05  2.915082e-05  3.056265e-05
## ASV3389      3.717957e-38  2.320106e-04  2.428685e-04  2.541028e-04
## ASV6880      2.145815e-38  1.262463e-04  1.317670e-04  1.374693e-04
## ASV2624     -4.081963e-39 -3.043467e-05 -3.208772e-05 -3.382818e-05
## ASV3686     -5.321176e-39 -4.308865e-05 -4.552102e-05 -4.813254e-05
## ASV12302    -3.040027e-38 -1.929840e-04 -2.020966e-04 -2.116192e-04
## ASV1184      3.829904e-38  2.371788e-04  2.482653e-04  2.596541e-04
## ASV3533     -1.727424e-38 -1.022634e-04 -1.069503e-04 -1.116105e-04
## ASV1735      9.671493e-39  5.709977e-05  5.958508e-05  6.216896e-05
## ASV0483     -1.721961e-38 -1.094354e-04 -1.146846e-04 -1.200913e-04
## ASV0928     -3.473252e-38 -2.180650e-04 -2.282966e-04 -2.389278e-04
## ASV12254    -3.040027e-38 -1.913047e-04 -2.002883e-04 -2.096379e-04
## ASV16025    -3.040027e-38 -1.913047e-04 -2.002731e-04 -2.096213e-04
## ASV3070     -3.040027e-38 -1.913047e-04 -2.002580e-04 -2.096047e-04
## ASV1850      6.876401e-39  4.481203e-05  4.690614e-05  4.917041e-05
## ASV8946     -3.040027e-38 -1.881795e-04 -1.969569e-04 -2.059887e-04
## ASV1536      2.557608e-38  1.578365e-04  1.651769e-04  1.727255e-04
## ASV4151      3.870283e-38  2.377255e-04  2.486534e-04  2.599624e-04
## ASV4585      5.197050e-38  3.192318e-04  3.338960e-04  3.490789e-04
## ASV4921     -1.272239e-38 -7.730103e-05 -8.086464e-05 -8.449181e-05
## ASV6172      3.040027e-38  1.881795e-04  1.969160e-04  2.059444e-04
## ASV6375     -3.040027e-38 -1.881795e-04 -1.969012e-04 -2.059284e-04
## ASV6501      3.553280e-38  2.148570e-04  2.245408e-04  2.345829e-04
## ASV17095    -3.040027e-38 -1.881795e-04 -1.968897e-04 -2.059160e-04
## ASV3679     -3.040027e-38 -1.881795e-04 -1.968750e-04 -2.058999e-04
## ASV5750      3.040027e-38  1.881795e-04  1.968603e-04  2.058839e-04
## ASV5922     -3.040027e-38 -1.881795e-04 -1.968456e-04 -2.058679e-04
## ASV7323     -3.040027e-38 -1.881795e-04 -1.968309e-04 -2.058519e-04
## ASV8515     -2.858717e-40 -2.598609e-06 -2.702473e-06 -2.861475e-06
## ASV8753     -3.040027e-38 -1.881794e-04 -1.968162e-04 -2.058357e-04
## ASV9197      2.076763e-38  1.291278e-04  1.351825e-04  1.414097e-04
## ASV1778      5.136227e-39  3.472629e-05  3.646327e-05  3.828883e-05
## ASV1241      3.956938e-38  2.430169e-04  2.541384e-04  2.656919e-04
## ASV1717      3.063194e-38  1.897597e-04  1.984548e-04  2.075613e-04
## ASV1112      3.616744e-38  2.185370e-04  2.284376e-04  2.386396e-04
## ASV3994      4.074550e-38  2.549915e-04  2.669419e-04  2.793187e-04
## ASV5511     -3.040027e-38 -1.889268e-04 -1.977285e-04 -2.068349e-04
## ASV8706      2.142665e-38  1.368746e-04  1.433957e-04  1.501938e-04
## ASV3049     -3.040027e-38 -1.889268e-04 -1.977165e-04 -2.068218e-04
## ASV4332      1.914390e-38  1.211334e-04  1.268165e-04  1.327647e-04
## ASV7411      3.529400e-38  2.148453e-04  2.245984e-04  2.347083e-04
## ASV7475     -3.040027e-38 -1.889268e-04 -1.977103e-04 -2.068152e-04
## ASV8988     -3.040027e-38 -1.889268e-04 -1.976954e-04 -2.067990e-04
## ASV0688     -6.647944e-38 -4.045767e-04 -4.230103e-04 -4.420537e-04
## ASV1946      1.854258e-38  1.096839e-04  1.145261e-04  1.195199e-04
## ASV3150      5.106883e-38  3.143990e-04  3.288784e-04  3.438665e-04
## ASV3508      2.562418e-38  1.541181e-04  1.610609e-04  1.682135e-04
## ASV3863     -3.040027e-38 -1.889268e-04 -1.976850e-04 -2.067876e-04
## ASV4544      2.482682e-38  1.491812e-04  1.558866e-04  1.628017e-04
## ASV4567      5.501723e-38  3.410066e-04  3.567654e-04  3.731471e-04
## ASV4855     -3.040027e-38 -1.889268e-04 -1.976696e-04 -2.067709e-04
## ASV4872      4.113850e-38  2.524147e-04  2.640128e-04  2.760007e-04
## ASV4881      2.854517e-38  1.810449e-04  1.895962e-04  1.985176e-04
## ASV5283      3.040027e-38  1.889268e-04  1.976576e-04  2.067577e-04
## ASV5302      3.622971e-38  2.233181e-04  2.335805e-04  2.442584e-04
## ASV5909      3.061925e-38  1.896020e-04  1.983835e-04  2.074810e-04
## ASV5933      2.277910e-38  1.414703e-04  1.480566e-04  1.548680e-04
## ASV6019      3.497173e-38  2.102741e-04  2.197388e-04  2.295013e-04
## ASV6043      1.313814e-38  8.385867e-05  8.784040e-05  9.199932e-05
## ASV6908      3.824426e-38  2.368505e-04  2.478355e-04  2.592050e-04
## ASV7245     -3.040027e-38 -1.889268e-04 -1.976657e-04 -2.067664e-04
## ASV7249     -3.040027e-38 -1.889268e-04 -1.976509e-04 -2.067503e-04
## ASV8349      1.007799e-38  6.353269e-05  6.651894e-05  6.962854e-05
## ASV7310     -3.040027e-38 -1.889268e-04 -1.976388e-04 -2.067370e-04
## ASV1893      2.391447e-38  1.466960e-04  1.533725e-04  1.603440e-04
## ASV2354      1.911282e-38  1.132842e-04  1.182654e-04  1.234373e-04
## ASV3435     -5.448955e-39 -3.181569e-05 -3.320433e-05 -3.462775e-05
## ASV0480      4.629385e-38  2.928217e-04  3.066051e-04  3.209760e-04
## ASV0955     -1.611560e-38 -1.017329e-04 -1.065078e-04 -1.114966e-04
## ASV10000     1.020886e-38  5.812879e-05  6.049974e-05  6.300982e-05
## ASV7215     -1.919022e-38 -1.218002e-04 -1.276170e-04 -1.336246e-04
## ASV10423    -4.307029e-38 -2.673359e-04 -2.798107e-04 -2.926796e-04
## ASV6008     -2.295054e-38 -1.427712e-04 -1.494599e-04 -1.563504e-04
## ASV9330     -4.307029e-38 -2.673359e-04 -2.797798e-04 -2.926461e-04
## ASV6051      4.307029e-38  2.673359e-04  2.797587e-04  2.926232e-04
## ASV1675      2.850556e-38  1.766986e-04  1.849573e-04  1.934524e-04
## ASV2043      1.796313e-38  1.143165e-04  1.196759e-04  1.253255e-04
## ASV3634      1.657424e-38  1.073097e-04  1.124428e-04  1.178483e-04
## ASV4077     -4.307029e-38 -2.673359e-04 -2.797484e-04 -2.926122e-04
## ASV4754      2.111215e-38  1.295542e-04  1.355087e-04  1.416643e-04
## ASV6095      5.041514e-38  3.074431e-04  3.214455e-04  3.359546e-04
## ASV6288      3.701042e-38  2.272036e-04  2.376571e-04  2.484550e-04
## ASV6507     -4.307029e-38 -2.673359e-04 -2.797356e-04 -2.925982e-04
## ASV8905      2.217060e-38  1.359803e-04  1.422097e-04  1.486680e-04
## ASV9728     -4.307029e-38 -2.673359e-04 -2.797182e-04 -2.925793e-04
## ASV11144    -4.307029e-38 -2.673359e-04 -2.796972e-04 -2.925565e-04
## ASV1615     -1.709114e-38 -1.074288e-04 -1.124152e-04 -1.176496e-04
## ASV2709     -5.265615e-38 -3.261790e-04 -3.412231e-04 -3.568765e-04
## ASV3003      4.124255e-38  2.582661e-04  2.703525e-04  2.829077e-04
## ASV5163     -3.973936e-38 -2.464743e-04 -2.578172e-04 -2.696584e-04
## ASV6622      2.738557e-38  1.727279e-04  1.808500e-04  1.893119e-04
## ASV1076     -4.094550e-38 -2.551633e-04 -2.669443e-04 -2.792684e-04
## ASV7895      1.010756e-38  6.074772e-05  6.343775e-05  6.624779e-05
## ASV10577    -3.040027e-38 -1.928987e-04 -2.020160e-04 -2.115314e-04
## ASV1272      3.040027e-38  1.928987e-04  2.020005e-04  2.115145e-04
## ASV2492     -1.394931e-38 -9.461253e-05 -9.932116e-05 -1.043102e-04
## ASV5195      3.716463e-38  2.321816e-04  2.429891e-04  2.542438e-04
## ASV5267      2.283564e-38  1.401888e-04  1.465987e-04  1.532559e-04
## ASV6317      3.129533e-38  1.974014e-04  2.066831e-04  2.163512e-04
## ASV2296      1.134976e-38  7.105442e-05  7.433086e-05  7.778684e-05
## ASV2290     -2.862878e-38 -1.747503e-04 -1.827382e-04 -1.909943e-04
## ASV3726      2.369877e-38  1.510246e-04  1.581759e-04  1.656546e-04
## ASV1169      2.077988e-38  1.282697e-04  1.342021e-04  1.403385e-04
## ASV0189     -1.913851e-38 -1.222784e-04 -1.280991e-04 -1.341725e-04
## ASV2729      7.315664e-38  4.635352e-04  4.852947e-04  5.080957e-04
## ASV3469      1.681316e-38  1.055506e-04  1.104588e-04  1.156005e-04
## ASV0762     -4.132117e-38 -2.523827e-04 -2.638736e-04 -2.757956e-04
## ASV9001     -3.942320e-38 -2.338743e-04 -2.447174e-04 -2.554491e-04
## ASV14604    -3.040027e-38 -1.875363e-04 -1.962898e-04 -2.052590e-04
## ASV7439      8.355129e-39  5.513076e-05  5.774817e-05  6.057457e-05
## ASV8625     -3.040027e-38 -1.875363e-04 -1.962775e-04 -2.052458e-04
## ASV11553     5.453855e-39  3.649723e-05  3.824553e-05  4.014239e-05
## ASV14440     1.807961e-39  5.557487e-06  5.529468e-06  5.497494e-06
## ASV16106    -3.040027e-38 -1.875363e-04 -1.962645e-04 -2.052319e-04
## ASV16110    -3.040027e-38 -1.875363e-04 -1.962497e-04 -2.052160e-04
## ASV2229      5.454727e-38  3.317481e-04  3.467966e-04  3.623987e-04
## ASV3854     -2.940801e-38 -1.814868e-04 -1.899200e-04 -1.986008e-04
## ASV5512     -3.040027e-38 -1.875363e-04 -1.962298e-04 -2.051947e-04
## ASV5939      4.051032e-38  2.517148e-04  2.633768e-04  2.755003e-04
## ASV6676     -2.099735e-38 -1.296288e-04 -1.356335e-04 -1.418343e-04
## ASV8381     -3.040027e-38 -1.875363e-04 -1.961968e-04 -2.051588e-04
## ASV2735      3.819536e-38  2.383531e-04  2.494871e-04  2.610226e-04
## ASV9816     -3.040027e-38 -1.875363e-04 -1.961870e-04 -2.051481e-04
## ASV1382      1.413492e-38  8.485637e-05  8.849882e-05  9.241991e-05
## ASV1408     -3.040027e-38 -1.880497e-04 -1.968391e-04 -2.058636e-04
## ASV4902      1.822626e-38  1.188619e-04  1.245469e-04  1.305726e-04
## ASV5600      2.358151e-38  1.456094e-04  1.522415e-04  1.592028e-04
## ASV0815     -6.893418e-39 -4.095596e-05 -4.273514e-05 -4.460409e-05
## ASV11867    -3.040027e-38 -1.880497e-04 -1.968314e-04 -2.058555e-04
## ASV16064    -3.040027e-38 -1.880497e-04 -1.968165e-04 -2.058395e-04
## ASV2250      3.778290e-38  2.360710e-04  2.470556e-04  2.584994e-04
## ASV2417      8.393779e-39  5.498759e-05  5.762734e-05  6.042548e-05
## ASV2807      5.078724e-38  3.078239e-04  3.218364e-04  3.362687e-04
## ASV3224     -3.040027e-38 -1.880496e-04 -1.967824e-04 -2.058026e-04
## ASV4115     -3.040027e-38 -1.880496e-04 -1.967676e-04 -2.057866e-04
## ASV4876      5.076969e-39  3.090318e-05  3.228119e-05  3.372790e-05
## ASV5291      3.000267e-38  1.833589e-04  1.917662e-04  2.004362e-04
## ASV5834      1.431891e-38  8.883356e-05  9.290578e-05  9.717113e-05
## ASV6896      3.600296e-39  2.089096e-05  2.175596e-05  2.267752e-05
## ASV7292     -3.040027e-38 -1.880496e-04 -1.967584e-04 -2.057767e-04
## ASV7924      1.717234e-38  1.079163e-04  1.129925e-04  1.182582e-04
## ASV0710      4.053541e-38  2.490368e-04  2.604155e-04  2.722530e-04
## ASV1925      3.557084e-38  2.169160e-04  2.268056e-04  2.370357e-04
## ASV4247     -3.040027e-38 -1.880496e-04 -1.967423e-04 -2.057592e-04
## ASV4549     -3.040027e-38 -1.880496e-04 -1.967276e-04 -2.057432e-04
## ASV4076      2.540680e-38  1.573982e-04  1.646470e-04  1.722062e-04
## ASV7063      2.439439e-38  1.527193e-04  1.598376e-04  1.672491e-04
## ASV1487      2.692193e-38  1.626816e-04  1.700131e-04  1.776056e-04
## ASV1405      1.037653e-38  6.696370e-05  7.020605e-05  7.356742e-05
## ASV3851      2.625913e-38  1.665276e-04  1.743868e-04  1.825837e-04
## ASV0896      8.120745e-39  5.092518e-05  5.324646e-05  5.572062e-05
## ASV5581      3.805940e-38  2.421543e-04  2.536292e-04  2.656057e-04
## ASV7053     -1.285656e-38 -7.996892e-05 -8.369233e-05 -8.755161e-05
## ASV7171     -3.040027e-38 -1.916490e-04 -2.006501e-04 -2.100354e-04
## ASV4017     -4.180093e-38 -2.625097e-04 -2.747755e-04 -2.875725e-04
## ASV5846      4.010423e-39  1.723843e-05  1.770025e-05  1.812655e-05
## ASV0203      7.819022e-40  2.034192e-06  1.951967e-06  1.917056e-06
## ASV13271     5.305006e-39  3.018169e-05  3.141730e-05  3.272029e-05
## ASV9487      2.095671e-38  1.213688e-04  1.265644e-04  1.319491e-04
## ASV2056     -4.300127e-38 -2.690723e-04 -2.816017e-04 -2.946628e-04
## ASV16933    -4.306987e-38 -2.651995e-04 -2.775325e-04 -2.901936e-04
## ASV0360      1.918749e-38  1.155774e-04  1.207641e-04  1.261452e-04
## ASV1798     -2.802420e-38 -1.725057e-04 -1.805041e-04 -1.887340e-04
## ASV17286    -3.040027e-38 -1.914653e-04 -2.004564e-04 -2.098217e-04
## ASV8175     -3.040027e-38 -1.914653e-04 -2.004412e-04 -2.098050e-04
## ASV6679      3.296473e-38  2.032509e-04  2.125905e-04  2.222934e-04
## ASV6776      1.622943e-38  9.825720e-05  1.027215e-04  1.073166e-04
## ASV9062     -3.040027e-38 -1.914653e-04 -2.004275e-04 -2.097900e-04
## ASV9564     -2.383930e-39 -1.677447e-05 -1.760784e-05 -1.852284e-05
## ASV6431     -3.040027e-38 -1.914653e-04 -2.004113e-04 -2.097721e-04
## ASV9940      1.268056e-38  7.828570e-05  8.188743e-05  8.562720e-05
## ASV7001     -4.306965e-38 -2.656047e-04 -2.779110e-04 -2.906028e-04
## ASV3044      4.866605e-38  3.000383e-04  3.138253e-04  3.281566e-04
## ASV6684      1.701217e-38  1.102322e-04  1.155467e-04  1.211028e-04
## ASV12278    -6.143921e-54  1.530461e-06  1.693128e-06  1.849665e-06
## ASV3543     -2.973498e-38 -1.782008e-04 -1.861640e-04 -1.944111e-04
## ASV6397     -6.143921e-54  1.530455e-06  1.690047e-06  1.846338e-06
## ASV9939     -6.143921e-54  1.530455e-06  1.689777e-06  1.846060e-06
## ASV9432      2.421299e-38  1.543643e-04  1.616790e-04  1.693263e-04
## ASV2630     -3.036049e-38 -1.921425e-04 -2.011898e-04 -2.106340e-04
## ASV2175      3.981968e-38  2.521290e-04  2.640616e-04  2.764709e-04
## ASV4107      3.313480e-38  2.081726e-04  2.178987e-04  2.280472e-04
## ASV9172     -3.754861e-39 -2.613361e-05 -2.751212e-05 -2.893022e-05
## ASV3141      3.886221e-38  2.473233e-04  2.590304e-04  2.712651e-04
## ASV9010     -3.040027e-38 -1.918541e-04 -2.008996e-04 -2.103073e-04
## ASV2550      3.065648e-38  1.904841e-04  1.992763e-04  2.084471e-04
## ASV5845     -3.040027e-38 -1.918541e-04 -2.008891e-04 -2.102959e-04
## ASV3998      3.040027e-38  1.918541e-04  2.008738e-04  2.102792e-04
## ASV1389     -3.519234e-38 -2.084464e-04 -2.178756e-04 -2.274081e-04
## ASV0615     -3.494985e-38 -2.170379e-04 -2.270969e-04 -2.375498e-04
## ASV9127     -4.295812e-38 -2.660239e-04 -2.784425e-04 -2.912200e-04
## ASV1190      6.227206e-38  3.791995e-04  3.964633e-04  4.143238e-04
## ASV1211      1.540939e-38  9.543088e-05  9.975473e-05  1.043344e-04
## ASV1766     -4.387851e-38 -2.733618e-04 -2.861759e-04 -2.993903e-04
## ASV2337      3.040027e-38  1.901482e-04  1.991446e-04  2.083800e-04
## ASV2463      6.547162e-39  4.089291e-05  4.288063e-05  4.486720e-05
## ASV2806      2.350639e-38  1.426239e-04  1.489910e-04  1.556859e-04
## ASV0439     -3.933876e-38 -2.450859e-04 -2.565738e-04 -2.684196e-04
## ASV0839      3.657136e-38  2.330023e-04  2.439795e-04  2.555045e-04
## ASV14975    -3.040027e-38 -1.901482e-04 -1.991175e-04 -2.083510e-04
## ASV17712    -3.040027e-38 -1.901482e-04 -1.991023e-04 -2.083347e-04
## ASV2010     -3.617871e-39 -2.172256e-05 -2.274884e-05 -2.375531e-05
## ASV2041      1.522290e-38  9.914111e-05  1.039512e-04  1.089710e-04
## ASV2124     -3.911540e-38 -2.452818e-04 -2.568207e-04 -2.687616e-04
## ASV2585      5.467705e-38  3.399271e-04  3.556852e-04  3.720660e-04
## ASV3314      4.261380e-38  2.685663e-04  2.811930e-04  2.943385e-04
## ASV5051     -4.435826e-39 -2.508472e-05 -2.619652e-05 -2.727019e-05
## ASV10784     1.549939e-38  9.565357e-05  1.000253e-04  1.045960e-04
## ASV3279     -3.040027e-38 -1.901482e-04 -1.990656e-04 -2.082950e-04
## ASV9498      2.517739e-39  1.352281e-05  1.403866e-05  1.457595e-05
## ASV1059     -3.201432e-38 -2.026505e-04 -2.121973e-04 -2.221637e-04
## ASV13008    -3.040027e-38 -1.901482e-04 -1.990501e-04 -2.082783e-04
## ASV15803    -3.040027e-38 -1.901482e-04 -1.990350e-04 -2.082619e-04
## ASV2559     -2.948843e-38 -1.845434e-04 -1.931675e-04 -2.021286e-04
## ASV2623     -3.040027e-38 -1.901482e-04 -1.990204e-04 -2.082459e-04
## ASV2802     -1.729596e-38 -1.069996e-04 -1.119754e-04 -1.171079e-04
## ASV3799      4.722875e-38  2.924438e-04  3.059715e-04  3.200077e-04
## ASV5274      2.926160e-40 -1.213347e-07 -1.623213e-07 -2.675312e-07
## ASV5835      1.840073e-38  1.170396e-04  1.225568e-04  1.283454e-04
## ASV7251     -3.040027e-38 -1.901482e-04 -1.990171e-04 -2.082422e-04
## ASV7616     -3.040027e-38 -1.901482e-04 -1.990020e-04 -2.082258e-04
## ASV9576     -3.040027e-38 -1.901482e-04 -1.989871e-04 -2.082094e-04
## ASV2870      2.222798e-38  1.393236e-04  1.458032e-04  1.525742e-04
## ASV3668     -1.934353e-38 -1.223508e-04 -1.280557e-04 -1.340585e-04
## ASV1633      1.449813e-38  9.240424e-05  9.678811e-05  1.013647e-04
## ASV6060      5.336585e-40 -2.832430e-06 -3.274915e-06 -3.734563e-06
## ASV6305      1.504178e-38  9.556114e-05  1.000784e-04  1.047954e-04
## ASV5164      1.050440e-38  6.259282e-05  6.537352e-05  6.824256e-05
## ASV7252     -3.040027e-38 -1.904667e-04 -1.993953e-04 -2.086594e-04
## ASV9343      2.549441e-38  1.637330e-04  1.715343e-04  1.797115e-04
## ASV6835     -5.243379e-39 -3.195744e-05 -3.342867e-05 -3.493621e-05
## ASV1264      3.746140e-38  2.322761e-04  2.429997e-04  2.541654e-04
## ASV0591      4.302786e-39  2.120185e-05  2.191394e-05  2.264048e-05
## ASV1351      4.271102e-38  2.678640e-04  2.803971e-04  2.934361e-04
## ASV14224    -3.040027e-38 -1.904667e-04 -1.993581e-04 -2.086189e-04
## ASV1432     -3.040027e-38 -1.904667e-04 -1.993430e-04 -2.086024e-04
## ASV1559     -2.528411e-38 -1.594524e-04 -1.669557e-04 -1.747647e-04
## ASV2182      4.778811e-38  2.962242e-04  3.099238e-04  3.241558e-04
## ASV2304     -2.708802e-39 -1.601150e-05 -1.670363e-05 -1.742935e-05
## ASV6838     -3.142838e-40 -1.672932e-06 -1.740085e-06 -1.806565e-06
## ASV1125     -4.350800e-39 -2.838401e-05 -2.976986e-05 -3.121142e-05
## ASV17948    -3.040027e-38 -1.904667e-04 -1.993376e-04 -2.085964e-04
## ASV2609      2.655132e-38  1.677912e-04  1.756864e-04  1.839219e-04
## ASV6128     -2.466133e-38 -1.560803e-04 -1.634252e-04 -1.710617e-04
## ASV1338      6.928014e-39  3.829831e-05  3.985094e-05  4.144080e-05
## ASV2136      1.168449e-38  6.962873e-05  7.270889e-05  7.590550e-05
## ASV0929     -2.820965e-38 -1.741655e-04 -1.821933e-04 -1.905272e-04
## ASV3479      1.970806e-38  1.201861e-04  1.258171e-04  1.314954e-04
## ASV0886      5.136435e-38  3.203104e-04  3.350813e-04  3.505603e-04
## ASV1652      2.340602e-38  1.468980e-04  1.537459e-04  1.609022e-04
## ASV1160      4.237225e-38  2.655264e-04  2.779175e-04  2.908296e-04
## ASV5260     -7.373515e-39 -4.969674e-05 -5.221326e-05 -5.481669e-05
## ASV2352      5.398417e-38  3.273339e-04  3.419761e-04  3.573119e-04
## ASV0986     -2.115293e-38 -1.295719e-04 -1.355023e-04 -1.416486e-04
## ASV2021      3.465695e-38  2.146963e-04  2.245627e-04  2.348670e-04
## ASV16599    -2.647078e-38 -1.746005e-04 -1.831446e-04 -1.920768e-04
## ASV3497      2.586345e-38  1.628295e-04  1.704221e-04  1.783828e-04
## ASV1305      1.673612e-38  1.091381e-04  1.143720e-04  1.198884e-04
## ASV0927     -4.266149e-38 -2.519204e-04 -2.629780e-04 -2.744173e-04
## ASV0647     -1.441760e-38 -8.332916e-05 -8.671363e-05 -9.038312e-05
## ASV1832     -1.733868e-38 -1.067927e-04 -1.116805e-04 -1.167754e-04
## ASV1277      2.048258e-38  1.271360e-04  1.329484e-04  1.390577e-04
## ASV22332    -3.040027e-38 -1.908312e-04 -1.997726e-04 -2.090723e-04
## ASV10080    -2.446061e-39 -2.302014e-05 -2.444863e-05 -2.596897e-05
## ASV14157     3.867611e-39  2.549700e-05  2.673826e-05  2.804568e-05
## ASV15829    -3.040027e-38 -1.908312e-04 -1.997570e-04 -2.090553e-04
## ASV3609     -3.040027e-38 -1.908312e-04 -1.997419e-04 -2.090388e-04
## ASV5737      7.314901e-39  4.282641e-05  4.471077e-05  4.663118e-05
## ASV1474      2.202122e-38  1.390647e-04  1.456286e-04  1.524442e-04
## ASV2028      3.244789e-38  1.915866e-04  2.000299e-04  2.087303e-04
## ASV0818      3.682930e-38  2.295910e-04  2.402419e-04  2.513380e-04
## ASV0505     -3.143796e-38 -1.984266e-04 -2.077189e-04 -2.174329e-04
## ASV1813      1.571428e-38  9.418886e-05  9.837599e-05  1.027263e-04
## ASV0512      3.207171e-38  2.057845e-04  2.154936e-04  2.257230e-04
## ASV5374     -2.330037e-38 -1.459687e-04 -1.528489e-04 -1.599570e-04
## ASV2927     -4.137624e-39 -1.947078e-05 -2.016972e-05 -2.077425e-05
## ASV3596      2.376141e-38  1.437805e-04  1.503764e-04  1.571040e-04
## ASV1137      1.438563e-38  8.598870e-05  8.987838e-05  9.383753e-05
## ASV4541      2.106487e-53  1.952358e-06  2.084692e-06  2.279736e-06
## ASV9872     -2.106487e-53 -1.952358e-06 -2.084468e-06 -2.279389e-06
## ASV0359     -1.119999e-38 -6.740368e-05 -7.046592e-05 -7.359740e-05
## ASV0720     -1.891173e-38 -1.149853e-04 -1.202130e-04 -1.256140e-04
## ASV10545    -2.106487e-53 -1.952360e-06 -2.093533e-06 -2.289060e-06
## ASV13384    -2.106487e-53 -1.952360e-06 -2.093294e-06 -2.288713e-06
## ASV1456      8.683763e-40  5.031627e-06  5.264267e-06  5.488839e-06
## ASV1751     -2.106487e-53 -1.952359e-06 -2.093304e-06 -2.288617e-06
## ASV18419    -2.106487e-53 -1.952359e-06 -2.093065e-06 -2.288270e-06
## ASV2970      2.106487e-53  1.952359e-06  2.092827e-06  2.287924e-06
## ASV4215      2.393974e-38  1.491568e-04  1.560465e-04  1.632469e-04
## ASV4742      4.532485e-39  2.515511e-05  2.623482e-05  2.729110e-05
## ASV5017      7.831685e-39  4.720189e-05  4.934989e-05  5.154769e-05
## ASV5139     -2.106487e-53 -1.952361e-06 -2.090722e-06 -2.285322e-06
## ASV9133     -2.106487e-53 -1.952361e-06 -2.090487e-06 -2.284977e-06
## ASV9447     -2.106487e-53 -1.952361e-06 -2.090254e-06 -2.284631e-06
## ASV0842     -2.413783e-38 -1.426757e-04 -1.489361e-04 -1.554283e-04
## ASV12293     1.725664e-38  1.001882e-04  1.045396e-04  1.090004e-04
## ASV1965      2.844644e-38  1.790447e-04  1.874457e-04  1.961979e-04
## ASV2005      3.328825e-38  1.972640e-04  2.060169e-04  2.150186e-04
## ASV5335      2.442849e-38  1.465528e-04  1.531782e-04  1.599636e-04
## ASV6438     -2.106487e-53 -1.952407e-06 -2.112397e-06 -2.308435e-06
## ASV7798     -2.106487e-53 -1.952406e-06 -2.112127e-06 -2.308087e-06
## ASV2691     -3.211971e-38 -2.017102e-04 -2.110857e-04 -2.209079e-04
## ASV9958      2.687628e-38  1.653211e-04  1.729277e-04  1.808031e-04
## ASV1512      9.289094e-39  5.968118e-05  6.254555e-05  6.553228e-05
## ASV1226      4.374569e-38  2.711604e-04  2.837823e-04  2.968215e-04
## ASV2130     -7.723118e-38 -4.785217e-04 -5.006904e-04 -5.236748e-04
## ASV0874     -2.421411e-38 -1.489597e-04 -1.558948e-04 -1.630141e-04
## ASV5436     -3.400927e-38 -2.127463e-04 -2.226497e-04 -2.329692e-04
## ASV0383     -3.945801e-38 -2.360391e-04 -2.465237e-04 -2.574045e-04
## ASV1882      3.860660e-38  2.307050e-04  2.410792e-04  2.517258e-04
## ASV2471     -2.097231e-38 -1.296294e-04 -1.357571e-04 -1.419774e-04
## ASV4049     -2.992334e-38 -1.844698e-04 -1.929303e-04 -2.017354e-04
## ASV3014     -1.716087e-38 -1.035414e-04 -1.082522e-04 -1.130790e-04
## ASV0316     -5.955330e-38 -3.692079e-04 -3.863331e-04 -4.040803e-04
## ASV1621     -4.188630e-38 -2.565615e-04 -2.683354e-04 -2.805039e-04
## ASV13266    -3.040027e-38 -1.880310e-04 -1.967731e-04 -2.057903e-04
## ASV1635     -3.015365e-38 -1.864703e-04 -1.951243e-04 -2.040637e-04
## ASV2042      2.212274e-38  1.370036e-04  1.433097e-04  1.498845e-04
## ASV2317     -3.625878e-38 -2.236060e-04 -2.339473e-04 -2.446332e-04
## ASV3697      2.775612e-38  1.693528e-04  1.770052e-04  1.849948e-04
## ASV6404      5.135272e-38  3.117925e-04  3.258395e-04  3.404771e-04
## ASV15616     1.598885e-39  1.252583e-05  1.318534e-05  1.392581e-05
## ASV10783    -3.040027e-38 -1.880310e-04 -1.967413e-04 -2.057561e-04
## ASV6912     -2.295194e-38 -1.411980e-04 -1.477063e-04 -1.544343e-04
## ASV1561      6.267759e-38  3.821985e-04  3.995751e-04  4.176061e-04
## ASV4404      4.212588e-38  2.600586e-04  2.720251e-04  2.844630e-04
## ASV1110      3.118002e-38  1.911420e-04  1.999124e-04  2.089835e-04
## ASV2844     -9.956794e-39 -6.424874e-05 -6.732303e-05 -7.054615e-05
## ASV5224      3.087616e-38  1.905833e-04  1.993904e-04  2.085025e-04
## ASV6300     -3.040027e-38 -1.906282e-04 -1.995356e-04 -2.088123e-04
## ASV8078     -3.040027e-38 -1.906282e-04 -1.995205e-04 -2.087959e-04
## ASV9722      7.638763e-40  1.322776e-06  1.273931e-06  1.155460e-06
## ASV6911     -3.040027e-38 -1.906282e-04 -1.995054e-04 -2.087793e-04
## ASV5474     -5.969814e-39 -3.880982e-05 -4.069483e-05 -4.265848e-05
## ASV2761     -7.256661e-38 -4.479138e-04 -4.685483e-04 -4.899670e-04
## ASV5943     -1.912214e-38 -1.236351e-04 -1.295870e-04 -1.358092e-04
## ASV0600     -6.366108e-39 -3.334988e-05 -3.469497e-05 -3.597916e-05
## ASV0608     -6.544018e-38 -4.021406e-04 -4.205838e-04 -4.397245e-04
## ASV1586      1.615427e-38  9.723264e-05  1.015491e-04  1.060698e-04
## ASV0206     -7.391413e-38 -4.478934e-04 -4.679175e-04 -4.888743e-04
## ASV4042     -3.297802e-38 -2.043479e-04 -2.137771e-04 -2.235893e-04
## ASV5304     -7.902358e-40 -5.910096e-06 -6.262520e-06 -6.599728e-06
## ASV0949     -9.954426e-39 -6.976028e-05 -7.336635e-05 -7.714917e-05
## ASV1856      3.790633e-38  2.353501e-04  2.461986e-04  2.575195e-04
## ASV2584      4.811356e-39  2.807272e-05  2.929520e-05  3.054228e-05
## ASV2287     -6.997076e-40 -1.106480e-05 -1.153362e-05 -1.238952e-05
## ASV2364     -5.420195e-38 -3.341246e-04 -3.495929e-04 -3.655579e-04
## ASV11481    -4.194247e-38 -2.653106e-04 -2.778538e-04 -2.908919e-04
## ASV2906     -1.450658e-38 -9.231112e-05 -9.662339e-05 -1.011809e-04
## ASV0161     -1.798367e-38 -1.108666e-04 -1.159217e-04 -1.212094e-04
## ASV0062     -1.180453e-37 -7.282112e-04 -7.617574e-04 -7.965580e-04
## ASV3811     -2.980117e-38 -1.730739e-04 -1.810806e-04 -1.888326e-04
## ASV0225      5.662909e-39  2.937864e-05  3.066917e-05  3.179734e-05
## ASV4672     -3.832617e-38 -2.336203e-04 -2.444883e-04 -2.555206e-04
## ASV1607     -2.685569e-39 -1.764699e-05 -1.850688e-05 -1.939515e-05
## ASV3060      7.063015e-39  4.582185e-05  4.802157e-05  5.033403e-05
## ASV2275     -5.375482e-39 -3.331198e-05 -3.484389e-05 -3.644276e-05
## ASV5375      2.043085e-38  1.299111e-04  1.360118e-04  1.424283e-04
## ASV0352     -6.192788e-38 -3.888798e-04 -4.071128e-04 -4.260695e-04
## ASV1107      1.733099e-38  1.118667e-04  1.170582e-04  1.226487e-04
## ASV4887      1.718053e-38  1.020024e-04  1.065120e-04  1.111718e-04
## ASV2397     -9.028261e-39 -5.176336e-05 -5.392783e-05 -5.618596e-05
## ASV7541     -1.993270e-38 -1.223339e-04 -1.280235e-04 -1.338388e-04
## ASV7387     -4.302709e-38 -2.672686e-04 -2.796719e-04 -2.925400e-04
## ASV1355      3.917059e-38  2.448450e-04  2.562816e-04  2.681627e-04
## ASV1764     -2.085633e-38 -1.280635e-04 -1.339308e-04 -1.400211e-04
## ASV1960     -4.042510e-38 -2.368067e-04 -2.476214e-04 -2.583191e-04
## ASV0484     -7.299950e-39 -4.521144e-05 -4.728820e-05 -4.945939e-05
## ASV2487      1.291002e-38  7.405702e-05  7.712177e-05  8.035695e-05
## ASV0422      3.880713e-38  2.298089e-04  2.403809e-04  2.508994e-04
## ASV0081     -2.232702e-38 -1.425361e-04 -1.492975e-04 -1.563713e-04
## ASV1341     -2.079569e-38 -1.241630e-04 -1.296945e-04 -1.354084e-04
## ASV1001     -4.892692e-38 -2.937031e-04 -3.067659e-04 -3.203586e-04
## ASV0317     -1.068471e-38 -7.039165e-05 -7.359957e-05 -7.717667e-05
## ASV2728     -3.277736e-38 -2.028971e-04 -2.123466e-04 -2.220885e-04
## ASV0884     -4.023153e-38 -2.591340e-04 -2.713716e-04 -2.843340e-04
## ASV0464      7.463143e-39  5.458217e-05  5.746750e-05  6.053813e-05
## ASV2963      2.928852e-38  1.782162e-04  1.862593e-04  1.946485e-04
## ASV4608      1.297067e-38  8.030720e-05  8.400718e-05  8.785700e-05
## ASV3534      3.394669e-38  2.006534e-04  2.094651e-04  2.185853e-04
## ASV0291     -2.814970e-38 -1.719970e-04 -1.798012e-04 -1.879255e-04
## ASV0635     -3.916218e-38 -2.470218e-04 -2.585954e-04 -2.706939e-04
## ASV0867      3.102547e-38  1.984717e-04  2.079015e-04  2.177720e-04
## ASV1206     -4.078787e-39 -2.339819e-05 -2.439738e-05 -2.541795e-05
## ASV1230      1.272669e-53 -1.265535e-06 -1.378581e-06 -1.509575e-06
## ASV1265      8.577871e-39  5.305895e-05  5.550061e-05  5.804528e-05
## ASV1291     -2.585478e-38 -1.633595e-04 -1.710165e-04 -1.790292e-04
## ASV1524      5.610366e-38  3.390966e-04  3.543108e-04  3.701364e-04
## ASV2153     -4.330589e-38 -2.616073e-04 -2.733591e-04 -2.855715e-04
## ASV2714     -1.272669e-53  1.265481e-06  1.356915e-06  1.485953e-06
## ASV4246      1.272669e-53 -1.265481e-06 -1.356760e-06 -1.485724e-06
## ASV0945      2.803351e-38  1.736239e-04  1.816268e-04  1.899554e-04
## ASV2380      6.686867e-38  4.045924e-04  4.227792e-04  4.416956e-04
## ASV0214     -1.148976e-38 -6.178379e-05 -6.418947e-05 -6.666249e-05
## ASV10461     1.228784e-53 -1.265492e-06 -1.380158e-06 -1.511222e-06
## ASV4177      2.024045e-38  1.188520e-04  1.240255e-04  1.293827e-04
## ASV0237     -4.635378e-38 -2.914533e-04 -3.050765e-04 -3.192965e-04
## ASV11323    -5.277895e-38 -3.295087e-04 -3.447907e-04 -3.607485e-04
## ASV2232     -9.531958e-39 -5.722932e-05 -5.976065e-05 -6.240775e-05
## ASV0115     -1.712936e-38 -1.062857e-04 -1.112065e-04 -1.163135e-04
## ASV1171      8.978561e-39  5.014013e-05  5.220358e-05  5.432044e-05
## ASV1942      3.654010e-38  2.282310e-04  2.388342e-04  2.498954e-04
## ASV1889      3.873430e-39  2.303459e-05  2.404969e-05  2.510148e-05
## ASV0920      7.755445e-39  5.042277e-05  5.283401e-05  5.538044e-05
## ASV1805     -4.737769e-38 -2.929627e-04 -3.064761e-04 -3.205148e-04
## ASV1712      2.881460e-38  1.758411e-04  1.838435e-04  1.921369e-04
## ASV1458      4.287325e-38  2.583661e-04  2.703470e-04  2.824047e-04
## ASV1985      4.462910e-38  2.742112e-04  2.867868e-04  2.998383e-04
## ASV2960     -3.040027e-38 -1.761494e-04 -1.842262e-04 -1.920921e-04
## ASV5207     -1.049172e-38 -5.427013e-05 -5.670508e-05 -5.879026e-05
## ASV8548     -3.040027e-38 -1.761493e-04 -1.842092e-04 -1.920751e-04
## ASV0449     -1.610441e-38 -1.045381e-04 -1.093509e-04 -1.145895e-04
## ASV0609     -3.870970e-38 -2.373693e-04 -2.480153e-04 -2.592600e-04
## ASV1038      1.579448e-38  9.187298e-05  9.578931e-05  9.987895e-05
## ASV1145     -9.789054e-39 -5.548431e-05 -5.790054e-05 -6.029985e-05
## ASV15767    -3.040027e-38 -1.761492e-04 -1.842048e-04 -1.920716e-04
## ASV1630      4.151871e-38  2.476836e-04  2.590746e-04  2.705073e-04
## ASV1911      4.951350e-38  3.076403e-04  3.218676e-04  3.366861e-04
## ASV1950      3.783749e-38  2.235603e-04  2.338146e-04  2.440262e-04
## ASV2583      3.040027e-38  1.761490e-04  1.841585e-04  1.920234e-04
## ASV2853     -4.291496e-38 -2.575926e-04 -2.693955e-04 -2.813587e-04
## ASV2948      3.040027e-38  1.761488e-04  1.841310e-04  1.919947e-04
## ASV3116     -4.736171e-38 -2.812277e-04 -2.939794e-04 -3.068783e-04
## ASV3160     -2.650559e-38 -1.517231e-04 -1.585359e-04 -1.652089e-04
## ASV3354      2.960353e-38  1.849327e-04  1.934508e-04  2.023940e-04
## ASV3368      3.040027e-38  1.761486e-04  1.840927e-04  1.919549e-04
## ASV3464     -3.040027e-38 -1.761485e-04 -1.840793e-04 -1.919411e-04
## ASV3577      3.040027e-38  1.761484e-04  1.840660e-04  1.919273e-04
## ASV3746      3.890034e-38  2.300827e-04  2.404311e-04  2.509283e-04
## ASV3942      1.097022e-38  7.473062e-05  7.840444e-05  8.234226e-05
## ASV4000      3.040027e-38  1.761483e-04  1.840441e-04  1.919043e-04
## ASV4207      4.936724e-38  3.119637e-04  3.266051e-04  3.419091e-04
## ASV4261      3.040027e-38  1.761482e-04  1.840325e-04  1.918923e-04
## ASV4466      8.465270e-39  6.272218e-05  6.585510e-05  6.937332e-05
## ASV4487     -3.040027e-38 -1.761481e-04 -1.840230e-04 -1.918829e-04
## ASV4572     -2.258842e-38 -1.329785e-04 -1.390615e-04 -1.451164e-04
## ASV4718      3.040027e-38  1.761479e-04  1.840011e-04  1.918600e-04
## ASV4757     -3.040027e-38 -1.761478e-04 -1.839879e-04 -1.918462e-04
## ASV4929     -3.040027e-38 -1.761477e-04 -1.839748e-04 -1.918323e-04
## ASV5611     -3.040027e-38 -1.761477e-04 -1.839616e-04 -1.918185e-04
## ASV5614     -3.040027e-38 -1.761476e-04 -1.839485e-04 -1.918047e-04
## ASV5898      2.504378e-38  1.519191e-04  1.587267e-04  1.658419e-04
## ASV7627     -7.966931e-39 -3.923632e-05 -4.076888e-05 -4.215458e-05
## ASV3105     -1.724925e-38 -9.717364e-05 -1.014166e-04 -1.056119e-04
## ASV4762     -4.289539e-38 -2.577678e-04 -2.694261e-04 -2.814054e-04
## ASV5622      3.040027e-38  1.761473e-04  1.839151e-04  1.917695e-04
## ASV7129      3.728348e-38  2.277817e-04  2.381587e-04  2.489299e-04
## ASV12138    -3.040027e-38 -1.761472e-04 -1.838974e-04 -1.917507e-04
## ASV1687     -4.283297e-38 -2.610681e-04 -2.730121e-04 -2.853508e-04
## ASV2187      2.278210e-38  1.308611e-04  1.365908e-04  1.423675e-04
## ASV2204      4.347622e-38  2.646242e-04  2.765431e-04  2.889873e-04
## ASV2914      3.508626e-38  2.057955e-04  2.149060e-04  2.242116e-04
## ASV3297     -3.040027e-38 -1.761469e-04 -1.838504e-04 -1.917005e-04
## ASV3310     -3.816497e-38 -2.256207e-04 -2.356465e-04 -2.459396e-04
## ASV3677      2.298936e-40  1.184277e-05  1.277787e-05  1.386708e-05
## ASV4508      3.040027e-38  1.761467e-04  1.838226e-04  1.916708e-04
## ASV6236     -1.593537e-38 -8.649407e-05 -9.001954e-05 -9.356065e-05
## ASV6285      3.040027e-38  1.761466e-04  1.838043e-04  1.916513e-04
## ASV7576     -3.040027e-38 -1.761465e-04 -1.837914e-04 -1.916375e-04
## ASV7917     -3.040027e-38 -1.761464e-04 -1.837786e-04 -1.916237e-04
## ASV9353     -3.040027e-38 -1.761463e-04 -1.837658e-04 -1.916099e-04
## ASV1656      4.798970e-38  2.903588e-04  3.033586e-04  3.169308e-04
## ASV0280     -4.339101e-38 -2.741662e-04 -2.870461e-04 -3.005009e-04
## ASV4747     -1.331073e-41  4.189617e-06  4.482768e-06  4.913869e-06
## ASV2108     -5.359446e-38 -3.364519e-04 -3.522661e-04 -3.686721e-04
## ASV0885      1.812532e-38  1.130426e-04  1.182124e-04  1.236755e-04
## ASV2538     -1.526049e-38 -9.221747e-05 -9.633473e-05 -1.006341e-04
## ASV0968      3.382676e-38  2.083374e-04  2.180551e-04  2.280026e-04
## ASV1229     -3.040027e-38 -1.872186e-04 -1.959140e-04 -2.048459e-04
## ASV13306    -3.040027e-38 -1.872186e-04 -1.958993e-04 -2.048301e-04
## ASV13952     1.945637e-38  1.152503e-04  1.202598e-04  1.255096e-04
## ASV14631     1.562039e-38  1.030440e-04  1.080275e-04  1.133178e-04
## ASV2119      3.764688e-38  2.228659e-04  2.326490e-04  2.427975e-04
## ASV2450      3.124035e-38  1.948286e-04  2.038036e-04  2.132239e-04
## ASV2656     -3.040027e-38 -1.872186e-04 -1.958932e-04 -2.048238e-04
## ASV2942     -2.301131e-39 -1.362149e-05 -1.427558e-05 -1.489746e-05
## ASV3302      2.742672e-38  1.672455e-04  1.749264e-04  1.828162e-04
## ASV6515      1.137735e-38  6.524617e-05  6.796388e-05  7.081758e-05
## ASV6674     -3.040027e-38 -1.872186e-04 -1.958811e-04 -2.048109e-04
## ASV7296     -1.094069e-38 -6.908647e-05 -7.237505e-05 -7.576178e-05
## ASV7903      1.738022e-38  1.034712e-04  1.079785e-04  1.127219e-04
## ASV7943     -3.040027e-38 -1.872186e-04 -1.958658e-04 -2.047944e-04
## ASV8864      2.437797e-38  1.395754e-04  1.454110e-04  1.515022e-04
## ASV9389      4.228958e-39  1.879284e-05  1.923089e-05  1.973785e-05
## ASV9869     -3.040027e-38 -1.872186e-04 -1.958557e-04 -2.047835e-04
## ASV1051      3.040027e-38  1.872186e-04  1.958411e-04  2.047677e-04
## ASV13035    -1.540383e-39 -8.386023e-06 -8.760015e-06 -9.102940e-06
## ASV15744    -1.090322e-40  4.294672e-06  4.691443e-06  5.169661e-06
## ASV2526      3.821323e-39  2.032603e-05  2.106486e-05  2.186400e-05
## ASV1156      1.611748e-38  9.823857e-05  1.026215e-04  1.072468e-04
## ASV13562    -3.040027e-38 -1.872186e-04 -1.958325e-04 -2.047587e-04
## ASV1438      2.593136e-38  1.632678e-04  1.708854e-04  1.788696e-04
## ASV2268     -3.040027e-38 -1.872186e-04 -1.958249e-04 -2.047505e-04
## ASV2797      1.390718e-38  8.938751e-05  9.363221e-05  9.809971e-05
## ASV3744      3.326655e-38  2.082468e-04  2.179017e-04  2.280049e-04
## ASV8076     -3.270340e-38 -2.016943e-04 -2.109717e-04 -2.206024e-04
## ASV7055      1.304288e-38  8.573386e-05  8.992546e-05  9.431274e-05
## ASV7493     -2.756429e-38 -1.707622e-04 -1.787036e-04 -1.869047e-04
## ASV1201      6.774573e-38  4.161725e-04  4.352727e-04  4.550694e-04
## ASV5736     -5.758250e-38 -3.593149e-04 -3.759769e-04 -3.933602e-04
## ASV0558      2.739951e-38  1.734823e-04  1.816549e-04  1.901780e-04
## ASV14399    -4.069046e-38 -2.496102e-04 -2.610126e-04 -2.728660e-04
## ASV2992     -2.339360e-39 -1.416567e-05 -1.478682e-05 -1.544723e-05
## ASV4303     -2.976416e-38 -1.832659e-04 -1.916738e-04 -2.004078e-04
## ASV0565     -3.365717e-38 -2.084965e-04 -2.181042e-04 -2.281200e-04
## ASV0977     -5.261467e-38 -3.126451e-04 -3.263970e-04 -3.407237e-04
## ASV0140      2.546252e-38  1.565631e-04  1.638569e-04  1.713191e-04
## ASV14421    -3.040027e-38 -1.877511e-04 -1.964971e-04 -2.054878e-04
## ASV16909    -6.451075e-39 -4.148159e-05 -4.353518e-05 -4.561340e-05
## ASV3762     -3.040027e-38 -1.877511e-04 -1.964795e-04 -2.054689e-04
## ASV7141     -3.040027e-38 -1.877511e-04 -1.964647e-04 -2.054530e-04
## ASV3291      4.748886e-38  2.977925e-04  3.117067e-04  3.261996e-04
## ASV10440    -3.040027e-38 -1.877511e-04 -1.964477e-04 -2.054345e-04
## ASV10802     9.417493e-39  5.746902e-05  6.003369e-05  6.274165e-05
## ASV1698      4.746417e-39  3.112965e-05  3.258691e-05  3.417182e-05
## ASV2121      3.040027e-38  1.877511e-04  1.964367e-04  2.054227e-04
## ASV3549     -4.279005e-38 -2.650881e-04 -2.773144e-04 -2.900373e-04
## ASV6379      3.677931e-38  2.225829e-04  2.325748e-04  2.429796e-04
## ASV6824     -3.040027e-38 -1.877511e-04 -1.964044e-04 -2.053875e-04
## ASV8254      2.877942e-39  1.930414e-05  2.024266e-05  2.124766e-05
## ASV9951      1.288762e-38  8.227718e-05  8.614090e-05  9.021974e-05
## ASV1515     -1.325853e-38 -7.904900e-05 -8.256602e-05 -8.619237e-05
## ASV4327      9.254372e-39  5.731058e-05  5.990621e-05  6.265412e-05
## ASV0341     -1.357087e-38 -8.671636e-05 -9.082761e-05 -9.513186e-05
## ASV5562     -2.412252e-38 -1.527544e-04 -1.599334e-04 -1.674482e-04
## ASV1412      6.767584e-38  4.201901e-04  4.396075e-04  4.598366e-04
## ASV0154     -5.391687e-38 -3.376522e-04 -3.533809e-04 -3.697903e-04
## ASV3163     -2.556213e-38 -1.567666e-04 -1.639344e-04 -1.713815e-04
## ASV1782     -4.025381e-38 -2.494899e-04 -2.609656e-04 -2.729380e-04
## ASV3993     -4.863140e-39 -2.741528e-05 -2.860255e-05 -2.977603e-05
## ASV3164      1.996896e-38  1.205963e-04  1.259348e-04  1.315465e-04
## ASV1024      2.056696e-39  1.485545e-05  1.568888e-05  1.652481e-05
## ASV0771     -5.626077e-38 -3.421347e-04 -3.575670e-04 -3.736414e-04
## ASV2223     -2.335779e-38 -1.501806e-04 -1.573477e-04 -1.648403e-04
## ASV1638      9.199732e-38  5.650340e-04  5.908374e-04  6.176987e-04
## ASV0232     -2.690318e-38 -1.657767e-04 -1.733601e-04 -1.812697e-04
## ASV6771     -2.883570e-38 -1.826630e-04 -1.913977e-04 -2.003840e-04
## ASV4243     -1.246675e-38 -7.278107e-05 -7.594039e-05 -7.921868e-05
## ASV0162     -5.455773e-38 -3.381678e-04 -3.537863e-04 -3.700166e-04
## ASV0049      3.725044e-39  2.330448e-05  2.440880e-05  2.554330e-05
## ASV4697     -3.040027e-38 -1.885197e-04 -1.972508e-04 -2.063126e-04
## ASV12326     1.025350e-38  6.056248e-05  6.322546e-05  6.597473e-05
## ASV12586    -3.040027e-38 -1.885197e-04 -1.972384e-04 -2.062991e-04
## ASV1879      2.400915e-38  1.492064e-04  1.561267e-04  1.633125e-04
## ASV2864      6.571510e-38  4.109978e-04  4.301091e-04  4.500490e-04
## ASV3111     -1.774514e-38 -1.096790e-04 -1.147406e-04 -1.199933e-04
## ASV5633     -1.712650e-38 -1.053262e-04 -1.101555e-04 -1.151703e-04
## ASV5864      1.157740e-38  6.489453e-05  6.759282e-05  7.034763e-05
## ASV6364      1.407538e-38  9.021596e-05  9.451297e-05  9.900945e-05
## ASV1598      1.872054e-38  1.163842e-04  1.217341e-04  1.273486e-04
## ASV2649     -1.043700e-38 -6.870681e-05 -7.206754e-05 -7.558495e-05
## ASV4664      2.562370e-38  1.557171e-04  1.627113e-04  1.700259e-04
## ASV2654      4.234179e-38  2.616071e-04  2.736195e-04  2.861354e-04
## ASV6636     -2.018176e-39 -1.743894e-05 -1.849033e-05 -1.958542e-05
## ASV3334      3.044128e-38  1.941038e-04  2.032174e-04  2.128255e-04
## ASV0046     -5.457316e-38 -3.460956e-04 -3.623844e-04 -3.794294e-04
## ASV0661      5.768901e-38  3.522135e-04  3.682115e-04  3.848477e-04
## ASV0774      2.536083e-38  1.577446e-04  1.649943e-04  1.725925e-04
## ASV3815      3.076857e-38  1.888117e-04  1.974224e-04  2.063859e-04
## ASV0575      3.177497e-38  1.908170e-04  1.993432e-04  2.081907e-04
## ASV1953     -4.234295e-38 -2.624900e-04 -2.746136e-04 -2.872187e-04
## ASV0610      1.317110e-38  7.929158e-05  8.299858e-05  8.669662e-05
## ASV0245     -1.536988e-38 -9.581752e-05 -1.002526e-04 -1.048840e-04
## ASV3805     -2.469840e-38 -1.404729e-04 -1.464188e-04 -1.525294e-04
## ASV1182      6.198618e-38  3.909835e-04  4.092039e-04  4.283459e-04
## ASV1941     -1.053244e-53  7.998062e-07  8.789480e-07  9.631801e-07
## ASV0080     -7.465377e-38 -4.612773e-04 -4.823802e-04 -5.044451e-04
## ASV1033      2.218680e-38  1.376599e-04  1.440093e-04  1.506284e-04
## ASV5330     -2.696718e-38 -1.654887e-04 -1.732846e-04 -1.811585e-04
## ASV9702     -4.296794e-38 -2.547269e-04 -2.661158e-04 -2.777721e-04
## ASV0358      1.539547e-39  7.152983e-06  7.363360e-06  7.576182e-06
## ASV2225      2.129628e-38  1.310271e-04  1.369992e-04  1.432359e-04
## ASV2606      1.370983e-39  6.313574e-06  6.506393e-06  6.688820e-06
## ASV3510     -3.287515e-38 -2.038272e-04 -2.132088e-04 -2.229995e-04
## ASV3069      1.218600e-38  7.053803e-05  7.355026e-05  7.668391e-05
## ASV3849      2.098387e-38  1.270692e-04  1.327740e-04  1.387127e-04
## ASV1810     -5.357440e-38 -3.204176e-04 -3.346484e-04 -3.494437e-04
## ASV2046      7.494635e-38  4.674087e-04  4.891181e-04  5.117212e-04
## ASV2451     -8.175374e-39 -5.584003e-05 -5.872834e-05 -6.168666e-05
## ASV4047      3.969876e-38  2.446556e-04  2.558134e-04  2.674875e-04
## ASV7402     -3.040027e-38 -1.923314e-04 -2.014830e-04 -2.109300e-04
## ASV8250      3.759591e-38  2.364646e-04  2.474832e-04  2.590239e-04
## ASV3468      3.307445e-38  2.037500e-04  2.130516e-04  2.227689e-04
## ASV3521      6.727842e-38  4.183210e-04  4.376467e-04  4.578104e-04
## ASV6363     -2.217174e-38 -1.414624e-04 -1.482576e-04 -1.552681e-04
## ASV6444      1.488326e-38  9.475712e-05  9.916270e-05  1.038529e-04
## ASV8231      1.808446e-38  1.102774e-04  1.152593e-04  1.204614e-04
## ASV0196     -1.017205e-37 -6.276319e-04 -6.564359e-04 -6.864291e-04
## ASV12801    -3.040027e-38 -1.923315e-04 -2.014903e-04 -2.109384e-04
## ASV12906    -3.040027e-38 -1.923315e-04 -2.014748e-04 -2.109217e-04
## ASV13040    -3.040027e-38 -1.923315e-04 -2.014593e-04 -2.109049e-04
## ASV1313     -2.374210e-39 -1.893803e-05 -2.002594e-05 -2.116128e-05
## ASV14008     8.226650e-39  5.402413e-05  5.660252e-05  5.937026e-05
## ASV1546      1.291952e-38  7.521898e-05  7.844996e-05  8.180452e-05
## ASV1637      5.856290e-38  3.624426e-04  3.791887e-04  3.965670e-04
## ASV17076     2.607171e-38  1.579720e-04  1.650558e-04  1.724456e-04
## ASV2061      8.845169e-38  5.405643e-04  5.651101e-04  5.906629e-04
## ASV2177      3.483571e-38  2.218697e-04  2.323633e-04  2.433425e-04
## ASV2943      5.337967e-38  3.286892e-04  3.437916e-04  3.594599e-04
## ASV3020      4.738565e-38  2.900538e-04  3.032469e-04  3.169797e-04
## ASV30254     3.196384e-39  1.500926e-05  1.541767e-05  1.588383e-05
## ASV3219      6.639039e-38  4.069113e-04  4.254257e-04  4.447222e-04
## ASV3352      5.688884e-38  3.545029e-04  3.709025e-04  3.880320e-04
## ASV3355      2.395848e-38  1.516701e-04  1.588735e-04  1.663248e-04
## ASV3377      4.426499e-38  2.754518e-04  2.881684e-04  3.014596e-04
## ASV3449      2.679313e-38  1.612507e-04  1.684320e-04  1.759183e-04
## ASV3893      3.040027e-38  1.923315e-04  2.014427e-04  2.108872e-04
## ASV4326      1.920208e-38  1.140547e-04  1.190362e-04  1.242475e-04
## ASV5016     -3.040027e-38 -1.923315e-04 -2.014319e-04 -2.108754e-04
## ASV5152      2.590729e-38  1.516365e-04  1.581860e-04  1.649935e-04
## ASV5666     -6.417701e-40 -6.917332e-06 -7.422931e-06 -7.910079e-06
## ASV5802     -3.120044e-38 -1.971133e-04 -2.064103e-04 -2.160731e-04
## ASV6070      2.293484e-38  1.379368e-04  1.441068e-04  1.505075e-04
## ASV6488      1.946783e-38  1.194304e-04  1.248421e-04  1.305094e-04
## ASV6562     -3.040027e-38 -1.923315e-04 -2.014066e-04 -2.108480e-04
## ASV6930      2.350916e-38  1.415457e-04  1.478770e-04  1.544528e-04
## ASV7243      4.189974e-38  2.557308e-04  2.673270e-04  2.793958e-04
## ASV7506      2.687935e-38  1.627575e-04  1.700722e-04  1.776825e-04
## ASV7553     -3.040027e-38 -1.923315e-04 -2.013953e-04 -2.108356e-04
## ASV8064      1.822989e-38  1.105705e-04  1.155371e-04  1.207138e-04
## ASV8434     -1.653849e-38 -1.066008e-04 -1.117210e-04 -1.170547e-04
## ASV8858     -3.040027e-38 -1.923315e-04 -2.013767e-04 -2.108153e-04
## ASV2600      1.748986e-38  1.106879e-04  1.158927e-04  1.213239e-04
## ASV3398      6.696859e-38  4.174286e-04  4.367484e-04  4.569247e-04
## ASV4584     -3.040027e-38 -1.923315e-04 -2.013543e-04 -2.107908e-04
## ASV4864      3.422318e-38  2.115136e-04  2.211929e-04  2.313162e-04
## ASV0082     -1.333591e-37 -8.256505e-04 -8.636055e-04 -9.032077e-04
## ASV9626      2.739491e-38  1.705128e-04  1.782886e-04  1.865042e-04
## ASV1617      1.316185e-38  7.551635e-05  7.867092e-05  8.197510e-05
## ASV2765     -6.442546e-39 -4.344956e-05 -4.569756e-05 -4.797373e-05
## ASV2167     -4.147505e-38 -2.565041e-04 -2.682531e-04 -2.805376e-04
## ASV1628      2.796254e-38  1.638933e-04  1.709436e-04  1.783190e-04
## ASV3260     -6.997128e-39 -4.095827e-05 -4.278322e-05 -4.462361e-05
## ASV3645      3.141325e-39  2.338159e-05  2.451529e-05  2.582178e-05
## ASV6057     -3.956546e-38 -2.447262e-04 -2.559713e-04 -2.676972e-04
## ASV0662     -5.668642e-39 -3.298996e-05 -3.440614e-05 -3.587682e-05
## ASV4267     -4.740777e-39 -3.099248e-05 -3.254683e-05 -3.412001e-05
## ASV1070      4.123518e-38  2.606247e-04  2.728527e-04  2.856466e-04
## ASV0633     -1.133285e-38 -6.802064e-05 -7.106292e-05 -7.421256e-05
## ASV0333      4.292369e-38  2.679762e-04  2.803921e-04  2.933700e-04
## ASV0966      3.269203e-38  2.038554e-04  2.132246e-04  2.230696e-04
## ASV1848      4.620204e-38  2.930367e-04  3.068254e-04  3.212621e-04
## ASV13390    -3.040027e-38 -1.874130e-04 -1.960749e-04 -2.050258e-04
## ASV14901    -3.040027e-38 -1.874130e-04 -1.960602e-04 -2.050099e-04
## ASV1676     -3.575227e-38 -2.162113e-04 -2.259085e-04 -2.360020e-04
## ASV1756     -3.698453e-39 -2.263726e-05 -2.368596e-05 -2.475745e-05
## ASV22537    -4.467302e-39 -2.610804e-05 -2.729454e-05 -2.846886e-05
## ASV3303     -2.381323e-40 -2.829267e-06 -3.082484e-06 -3.291225e-06
## ASV4030     -1.291460e-38 -7.842669e-05 -8.201992e-05 -8.570299e-05
## ASV4871      2.388270e-38  1.495826e-04  1.564909e-04  1.637565e-04
## ASV5536      1.504228e-39  9.314311e-06  9.691860e-06  1.013705e-05
## ASV5700      1.081935e-38  6.711240e-05  7.014893e-05  7.336706e-05
## ASV8957      2.173704e-38  1.256629e-04  1.309829e-04  1.365367e-04
## ASV11210     1.823941e-38  1.188673e-04  1.245885e-04  1.306137e-04
## ASV7585     -3.040027e-38 -1.874130e-04 -1.960541e-04 -2.050039e-04
## ASV8596     -3.040027e-38 -1.874130e-04 -1.960395e-04 -2.049880e-04
## ASV9532     -1.249619e-38 -7.547227e-05 -7.889242e-05 -8.241249e-05
## ASV4254      2.156558e-38  1.354143e-04  1.416887e-04  1.482820e-04
## ASV13299    -3.040027e-38 -1.874130e-04 -1.960264e-04 -2.049739e-04
## ASV15627    -3.040027e-38 -1.874130e-04 -1.960119e-04 -2.049580e-04
## ASV6302     -2.623933e-38 -1.507251e-04 -1.571242e-04 -1.637604e-04
## ASV3040      1.210613e-38  7.535094e-05  7.879265e-05  8.242329e-05
## ASV0632      2.456671e-38  1.532652e-04  1.603883e-04  1.678082e-04
## ASV3694      3.937979e-38  2.440474e-04  2.552869e-04  2.670042e-04
## ASV1592     -8.225889e-39 -4.632693e-05 -4.825360e-05 -5.023747e-05
## ASV0538      1.956246e-38  1.239503e-04  1.298167e-04  1.359266e-04
## ASV0832      4.413547e-38  2.727480e-04  2.852434e-04  2.982982e-04
## ASV0727      3.240024e-38  2.052579e-04  2.149250e-04  2.250274e-04
## ASV1165     -4.243174e-38 -2.643507e-04 -2.765874e-04 -2.893588e-04
## ASV1325      2.978504e-39  2.803269e-05  2.978115e-05  3.165208e-05
## ASV0819      7.624776e-38  4.744835e-04  4.963932e-04  5.192866e-04
## ASV2251      4.388158e-38  2.566459e-04  2.677100e-04  2.792199e-04
## ASV0100     -2.715520e-39 -1.638220e-05 -1.710137e-05 -1.786046e-05
## ASV0444     -2.034690e-38 -1.265031e-04 -1.323313e-04 -1.384380e-04
## ASV0800      1.023374e-37  6.220546e-04  6.500667e-04  6.792950e-04
## ASV2432      3.064522e-39  1.474125e-05  1.520939e-05  1.569978e-05
## ASV2883      3.277645e-39  1.773516e-05  1.842055e-05  1.913062e-05
## ASV3894      4.022887e-39  2.041883e-05  2.113385e-05  2.186825e-05
## ASV2367      7.032013e-38  4.341136e-04  4.539856e-04  4.747399e-04
## ASV3724     -4.210973e-38 -2.582322e-04 -2.701207e-04 -2.823838e-04
## ASV2112     -3.529808e-38 -2.200352e-04 -2.302050e-04 -2.408335e-04
## ASV3661      1.197793e-38  7.595683e-05  7.953518e-05  8.327809e-05
## ASV2096     -2.484148e-38 -1.587756e-04 -1.662946e-04 -1.741611e-04
## ASV3551     -3.048313e-38 -1.851950e-04 -1.935215e-04 -2.022020e-04
## ASV11343    -6.929173e-40 -5.980268e-06 -6.354878e-06 -6.737031e-06
## ASV2051      2.522410e-38  1.579755e-04  1.653165e-04  1.730052e-04
## ASV2617     -3.522060e-38 -2.174484e-04 -2.274342e-04 -2.378318e-04
## ASV0125     -1.539783e-38 -9.611700e-05 -1.005737e-04 -1.052210e-04
## ASV0372      5.367925e-38  3.314375e-04  3.466241e-04  3.624712e-04
## ASV6751     -4.053261e-38 -2.478039e-04 -2.592502e-04 -2.709846e-04
## ASV10810     8.931547e-39  5.541104e-05  5.795288e-05  6.062211e-05
## ASV0461     -2.242560e-38 -1.410224e-04 -1.476074e-04 -1.544898e-04
## ASV1945     -1.310297e-38 -8.348082e-05 -8.743520e-05 -9.156809e-05
## ASV0882     -1.037686e-38 -7.075338e-05 -7.431636e-05 -7.805969e-05
## ASV4040     -5.769967e-39 -3.599195e-05 -3.766859e-05 -3.940140e-05
## ASV0109     -4.721853e-40 -2.523926e-06 -2.615547e-06 -2.712550e-06
## ASV0174      1.933194e-38  1.123340e-04  1.171656e-04  1.221543e-04
## ASV2851      3.199151e-38  1.914681e-04  1.999223e-04  2.087413e-04
## ASV5312      5.312496e-39  3.226341e-05  3.372442e-05  3.525441e-05
## ASV9402     -4.325222e-38 -2.656962e-04 -2.777873e-04 -2.904149e-04
## ASV4870     -3.516589e-38 -2.146671e-04 -2.245437e-04 -2.346891e-04
## ASV0589      4.139692e-38  2.562793e-04  2.680571e-04  2.803480e-04
## ASV1221     -8.777030e-54  5.280853e-07  5.767836e-07  6.286130e-07
## ASV6028     -4.018858e-38 -2.480878e-04 -2.594367e-04 -2.712985e-04
## ASV5106     -1.554329e-38 -9.367488e-05 -9.786305e-05 -1.022199e-04
## ASV4977     -4.326786e-39 -3.279587e-05 -3.459671e-05 -3.648893e-05
## ASV5715     -2.635914e-38 -1.629537e-04 -1.704258e-04 -1.782295e-04
## ASV4182      9.114300e-39  6.084561e-05  6.386204e-05  6.702635e-05
## ASV2383     -1.224025e-39 -1.270653e-05 -1.354493e-05 -1.444057e-05
## ASV3985      4.632261e-38  2.918889e-04  3.055420e-04  3.198213e-04
## ASV2787     -3.657967e-38 -2.204714e-04 -2.305185e-04 -2.407968e-04
## ASV6756     -3.021509e-38 -1.888915e-04 -1.977458e-04 -2.069067e-04
## ASV1634     -4.979796e-38 -3.034941e-04 -3.171843e-04 -3.314799e-04
## ASV0649     -1.484206e-38 -9.262162e-05 -9.692184e-05 -1.014001e-04
## ASV1591     -2.369798e-53 -5.085902e-06 -5.563884e-06 -6.070546e-06
## ASV1854      4.958603e-38  3.134453e-04  3.281545e-04  3.435369e-04
## ASV4205      3.306676e-38  2.090174e-04  2.188216e-04  2.290794e-04
## ASV3293     -1.995820e-38 -1.214188e-04 -1.268846e-04 -1.325933e-04
## ASV1631      2.297533e-38  1.423953e-04  1.489281e-04  1.557697e-04
## ASV1747     -1.242790e-38 -8.049638e-05 -8.436975e-05 -8.842410e-05
## ASV5634      1.045123e-38  6.457672e-05  6.748993e-05  7.058017e-05
## ASV0965     -1.657955e-38 -1.017126e-04 -1.063348e-04 -1.111647e-04
## ASV1094      2.858736e-38  1.754833e-04  1.834833e-04  1.918233e-04
## ASV2744     -1.141014e-53 -5.183182e-06 -5.668809e-06 -6.184766e-06
## ASV7212     -4.215240e-38 -2.651084e-04 -2.774777e-04 -2.904052e-04
## ASV0344     -2.838384e-38 -1.759738e-04 -1.840707e-04 -1.925248e-04
## ASV11812    -3.040027e-38 -1.902559e-04 -1.991710e-04 -2.084081e-04
## ASV7867     -4.133840e-39 -2.735272e-05 -2.875550e-05 -3.016356e-05
## ASV6670      2.913185e-38  1.739218e-04  1.815887e-04  1.895955e-04
## ASV10991     1.901303e-39  4.282246e-06  4.070833e-06  3.875438e-06
## ASV1281      5.335600e-38  3.394320e-04  3.554512e-04  3.722246e-04
## ASV12845    -3.040027e-38 -1.902560e-04 -1.991580e-04 -2.083940e-04
## ASV1833     -3.040027e-38 -1.902560e-04 -1.991429e-04 -2.083776e-04
## ASV2211      2.086413e-38  1.244988e-04  1.299561e-04  1.356765e-04
## ASV3920      4.418922e-38  2.690319e-04  2.811459e-04  2.937978e-04
## ASV4545     -3.448612e-38 -2.161412e-04 -2.262371e-04 -2.367448e-04
## ASV4710     -3.774718e-38 -2.360865e-04 -2.470721e-04 -2.585213e-04
## ASV4978      5.969515e-39  3.759960e-05  3.933642e-05  4.117330e-05
## ASV9630     -9.827452e-40 -6.547209e-06 -6.887962e-06 -7.227387e-06
## ASV9797     -2.502353e-40 -6.088039e-06 -6.609903e-06 -7.146665e-06
## ASV13469    -3.040027e-38 -1.902560e-04 -1.991028e-04 -2.083339e-04
## ASV14961    -1.112200e-38 -6.945500e-05 -7.268035e-05 -7.604133e-05
## ASV6259      1.778413e-38  1.073677e-04  1.121546e-04  1.171544e-04
## ASV6294     -2.162499e-38 -1.354590e-04 -1.417561e-04 -1.483331e-04
## ASV6883     -9.828994e-39 -6.326825e-05 -6.629059e-05 -6.945172e-05
## ASV7041     -2.462302e-38 -1.568967e-04 -1.643071e-04 -1.720637e-04
## ASV4363     -3.040027e-38 -1.849001e-04 -1.934240e-04 -2.021310e-04
## ASV1784     -4.345424e-38 -2.690979e-04 -2.815453e-04 -2.944625e-04
## ASV2140      3.696063e-39  2.398900e-05  2.499772e-05  2.618976e-05
## ASV3202      3.040027e-38  1.849001e-04  1.934005e-04  2.021059e-04
## ASV6017     -3.040027e-38 -1.849001e-04 -1.933862e-04 -2.020905e-04
## ASV9129      1.550687e-38  9.325929e-05  9.734452e-05  1.016606e-04
## ASV0917      3.114227e-38  1.896477e-04  1.983474e-04  2.072871e-04
## ASV10584    -1.190688e-39 -3.106852e-06 -3.148842e-06 -3.084124e-06
## ASV11218     2.001193e-38  1.206135e-04  1.259413e-04  1.315413e-04
## ASV11229     2.084112e-39  1.713119e-05  1.802123e-05  1.905442e-05
## ASV11604    -3.080520e-39 -2.084926e-05 -2.200884e-05 -2.311349e-05
## ASV2103     -3.538295e-38 -2.169844e-04 -2.269763e-04 -2.372863e-04
## ASV2165     -3.040027e-38 -1.849001e-04 -1.933455e-04 -2.020471e-04
## ASV2340      3.467578e-38  2.060139e-04  2.150650e-04  2.244844e-04
## ASV3738     -3.040027e-38 -1.849000e-04 -1.933288e-04 -2.020291e-04
## ASV4012      9.229818e-39  5.621445e-05  5.869138e-05  6.132987e-05
## ASV4094     -3.040027e-38 -1.849000e-04 -1.933168e-04 -2.020162e-04
## ASV4454     -3.040027e-38 -1.849000e-04 -1.933026e-04 -2.020007e-04
## ASV7031      6.628060e-39  4.344030e-05  4.550437e-05  4.771283e-05
## ASV7087     -1.213891e-38 -7.094942e-05 -7.406542e-05 -7.725328e-05
## ASV4159      1.911772e-39  1.101499e-05  1.142154e-05  1.189800e-05
## ASV5084     -3.040027e-38 -1.849000e-04 -1.932864e-04 -2.019833e-04
## ASV6584     -3.040027e-38 -1.849000e-04 -1.932723e-04 -2.019679e-04
## ASV9614     -3.040027e-38 -1.849000e-04 -1.932581e-04 -2.019525e-04
## ASV16068    -3.040027e-38 -1.848999e-04 -1.932440e-04 -2.019371e-04
## ASV2141     -4.170490e-38 -2.466569e-04 -2.574560e-04 -2.686997e-04
## ASV0395     -2.642619e-39 -1.726359e-05 -1.810118e-05 -1.898065e-05
## ASV5640     -6.567418e-39 -4.277969e-05 -4.484505e-05 -4.700632e-05
## ASV2854     -3.441828e-38 -2.080972e-04 -2.174134e-04 -2.271327e-04
## ASV3825     -5.932104e-38 -3.659099e-04 -3.826403e-04 -4.001197e-04
## ASV0481      6.628359e-38  3.997532e-04  4.175919e-04  4.362149e-04
## ASV3304      2.906600e-39  1.854120e-05  1.942008e-05  2.034120e-05
## ASV0445      3.962952e-38  2.428707e-04  2.538954e-04  2.654087e-04
## ASV1845     -2.009961e-38 -1.271652e-04 -1.331353e-04 -1.393782e-04
## ASV3110     -2.302631e-38 -1.407406e-04 -1.471169e-04 -1.537850e-04
##                                                                    
## (Intercept) -2.319684e-06 -2.697601e-06 -3.136104e-06 -3.644604e-06
## ASV1236      2.182917e-04  2.280817e-04  2.382815e-04  2.489060e-04
## ASV0421     -3.830610e-04 -4.001105e-04 -4.178649e-04 -4.363485e-04
## ASV0691     -3.302667e-04 -3.445119e-04 -3.593053e-04 -3.746621e-04
## ASV0899     -5.210495e-07 -1.526746e-07  2.653031e-07  7.376647e-07
## ASV1004      4.359075e-04  4.553409e-04  4.755797e-04  4.966518e-04
## ASV1041     -2.977163e-04 -3.111261e-04 -3.251037e-04 -3.396699e-04
## ASV1058      4.060670e-04  4.242214e-04  4.431340e-04  4.628316e-04
## ASV12542     1.230172e-04  1.283003e-04  1.337850e-04  1.394765e-04
## ASV1294      4.741660e-04  4.955945e-04  5.179381e-04  5.412311e-04
## ASV13113     1.671614e-04  1.748339e-04  1.828456e-04  1.912103e-04
## ASV1318      4.146359e-04  4.333194e-04  4.527948e-04  4.730915e-04
## ASV2269     -1.259508e-04 -1.317380e-04 -1.377790e-04 -1.440839e-04
## ASV2542      2.684095e-04  2.809602e-04  2.940858e-04  3.078117e-04
## ASV2660     -2.396987e-04 -2.504252e-04 -2.615986e-04 -2.732346e-04
## ASV2737     -1.610823e-05 -1.709064e-05 -1.813603e-05 -1.924865e-05
## ASV2840      3.116788e-04  3.252415e-04  3.393360e-04  3.539781e-04
## ASV3053      1.574659e-05  1.635976e-05  1.699213e-05  1.764380e-05
## ASV3077      9.807940e-05  1.024272e-04  1.069548e-04  1.116682e-04
## ASV3134      3.422426e-04  3.581599e-04  3.748007e-04  3.921961e-04
## ASV3140      1.534922e-04  1.607011e-04  1.682405e-04  1.761247e-04
## ASV3579      5.953427e-05  6.243551e-05  6.548196e-05  6.868106e-05
## ASV6119     -1.259295e-04 -1.317147e-04 -1.377535e-04 -1.440559e-04
## ASV7557     -1.259192e-04 -1.317034e-04 -1.377411e-04 -1.440425e-04
## ASV8422      6.398923e-05  6.659433e-05  6.928667e-05  7.206743e-05
## ASV1086     -3.311476e-05 -3.451474e-05 -3.596761e-05 -3.747477e-05
## ASV1310      2.327085e-04  2.431591e-04  2.540504e-04  2.653984e-04
## ASV15750    -6.112393e-05 -6.396011e-05 -6.692201e-05 -7.001470e-05
## ASV16905    -1.259139e-04 -1.316975e-04 -1.377347e-04 -1.440353e-04
## ASV2033      2.269755e-04  2.373029e-04  2.480785e-04  2.593197e-04
## ASV2089      8.680023e-05  9.082145e-05  9.502130e-05  9.940705e-05
## ASV2127      3.325033e-04  3.472551e-04  3.626116e-04  3.785931e-04
## ASV2725      3.777564e-04  3.943899e-04  4.116952e-04  4.296941e-04
## ASV2804     -1.259103e-04 -1.316935e-04 -1.377302e-04 -1.440304e-04
## ASV3075      2.382653e-04  2.488922e-04  2.599615e-04  2.714890e-04
## ASV3327      2.239430e-04  2.341905e-04  2.448886e-04  2.560555e-04
## ASV3342      2.489022e-04  2.604134e-04  2.724392e-04  2.850008e-04
## ASV3532     -2.234480e-04 -2.337091e-04 -2.444217e-04 -2.556036e-04
## ASV3600      2.788692e-04  2.914685e-04  3.046069e-04  3.183050e-04
## ASV4013      2.341051e-04  2.445241e-04  2.553739e-04  2.666693e-04
## ASV4136      2.359898e-04  2.465471e-04  2.575447e-04  2.689985e-04
## ASV4195      1.258945e-04  1.316762e-04  1.377113e-04  1.440097e-04
## ASV4407     -1.258842e-04 -1.316649e-04 -1.376989e-04 -1.439962e-04
## ASV4717      2.439400e-06  2.263318e-06  2.055778e-06  1.813577e-06
## ASV6794      1.223613e-04  1.275167e-04  1.328606e-04  1.383974e-04
## ASV8324     -1.258800e-04 -1.316603e-04 -1.376938e-04 -1.439904e-04
## ASV8981     -3.619920e-05 -3.784221e-05 -3.955418e-05 -4.133747e-05
## ASV9859      9.312318e-05  9.753908e-05  1.021644e-04  1.070089e-04
## ASV0936     -1.909995e-04 -1.995217e-04 -2.083994e-04 -2.176453e-04
## ASV12683    -2.285762e-05 -2.408837e-05 -2.538788e-05 -2.676008e-05
## ASV1293      2.835249e-04  2.961300e-04  3.092530e-04  3.229113e-04
## ASV13055    -3.272844e-05 -3.426895e-05 -3.587879e-05 -3.756073e-05
## ASV17063    -1.258612e-04 -1.316397e-04 -1.376713e-04 -1.439658e-04
## ASV2228      1.258509e-04  1.316284e-04  1.376589e-04  1.439524e-04
## ASV2769     -2.624090e-05 -2.745874e-05 -2.873004e-05 -3.005684e-05
## ASV2803      5.357652e-05  5.567301e-05  5.783156e-05  6.005219e-05
## ASV2896      1.515586e-04  1.583518e-04  1.654323e-04  1.728108e-04
## ASV3062      4.537112e-05  4.753060e-05  4.979347e-05  5.216469e-05
## ASV3107      1.842541e-04  1.925894e-04  2.012828e-04  2.103478e-04
## ASV3265      3.670591e-04  3.833001e-04  4.002029e-04  4.177892e-04
## ASV3666     -1.043790e-05 -1.101496e-05 -1.162473e-05 -1.226906e-05
## ASV4497      8.637092e-05  9.018864e-05  9.416343e-05  9.830078e-05
## ASV6914     -4.717457e-05 -4.951850e-05 -5.198000e-05 -5.456491e-05
## ASV0576     -4.319348e-04 -4.507332e-04 -4.702708e-04 -4.905697e-04
## ASV0673      1.160165e-04  1.215920e-04  1.274356e-04  1.335598e-04
## ASV0772      1.284531e-04  1.340952e-04  1.399653e-04  1.460708e-04
## ASV0862     -1.048332e-04 -1.093180e-04 -1.139726e-04 -1.188014e-04
## ASV0898      1.109390e-04  1.162319e-04  1.217754e-04  1.275811e-04
## ASV0910      2.395352e-04  2.508413e-04  2.626754e-04  2.750615e-04
## ASV0964     -1.568988e-04 -1.637997e-04 -1.709795e-04 -1.784473e-04
## ASV10059     1.099020e-04  1.150343e-04  1.204033e-04  1.260197e-04
## ASV10263    -1.259004e-04 -1.316823e-04 -1.377176e-04 -1.440163e-04
## ASV1088      1.262081e-04  1.321308e-04  1.383274e-04  1.448103e-04
## ASV1101      2.130047e-04  2.226314e-04  2.326694e-04  2.431343e-04
## ASV1183      1.405123e-04  1.470994e-04  1.539881e-04  1.611913e-04
## ASV11956     4.866853e-05  5.053205e-05  5.244656e-05  5.441160e-05
## ASV12774    -2.286932e-05 -2.414649e-05 -2.549865e-05 -2.693028e-05
## ASV1321      5.337510e-05  5.599344e-05  5.874303e-05  6.163056e-05
## ASV13793    -1.258867e-04 -1.316673e-04 -1.377011e-04 -1.439981e-04
## ASV14482    -1.468614e-05 -1.556304e-05 -1.649470e-05 -1.748452e-05
## ASV15483     8.261678e-05  8.624075e-05  9.001111e-05  9.393276e-05
## ASV2062      5.439753e-04  5.686629e-04  5.944148e-04  6.212718e-04
## ASV2132      2.435198e-04  2.545555e-04  2.660667e-04  2.780719e-04
## ASV2413      3.486350e-04  3.641590e-04  3.803267e-04  3.971607e-04
## ASV2490      2.305836e-04  2.407889e-04  2.514106e-04  2.624629e-04
## ASV2594      1.239246e-04  1.294222e-04  1.351476e-04  1.411093e-04
## ASV2822     -1.259008e-04 -1.316825e-04 -1.377177e-04 -1.440161e-04
## ASV2863      2.161760e-04  2.258938e-04  2.360209e-04  2.465720e-04
## ASV2910      2.745737e-04  2.865773e-04  2.990579e-04  3.120305e-04
## ASV2980      1.043596e-04  1.091493e-04  1.141482e-04  1.193645e-04
## ASV3307      1.258827e-04  1.316627e-04  1.376960e-04  1.439923e-04
## ASV3474      1.928365e-04  2.018587e-04  2.112962e-04  2.211675e-04
## ASV3502      3.976312e-04  4.155252e-04  4.341775e-04  4.536160e-04
## ASV4236      2.010881e-04  2.099144e-04  2.190949e-04  2.286408e-04
## ASV4842     -7.042209e-05 -7.375466e-05 -7.724110e-05 -8.088798e-05
## ASV4894     -1.258929e-04 -1.316738e-04 -1.377081e-04 -1.440055e-04
## ASV5290      1.499551e-04  1.567100e-04  1.637526e-04  1.710936e-04
## ASV5501      2.694885e-05  2.811383e-05  2.932575e-05  3.058633e-05
## ASV5795      9.959803e-05  1.041039e-04  1.088041e-04  1.137064e-04
## ASV5987     -1.258958e-04 -1.316770e-04 -1.377115e-04 -1.440093e-04
## ASV6267     -1.258855e-04 -1.316657e-04 -1.376992e-04 -1.439958e-04
## ASV6862      2.337131e-04  2.438409e-04  2.543634e-04  2.652920e-04
## ASV7145      4.023792e-05  4.182716e-05  4.346557e-05  4.515356e-05
## ASV7673     -1.258819e-04 -1.316617e-04 -1.376948e-04 -1.439909e-04
## ASV7789      4.202687e-05  4.401372e-05  4.609482e-05  4.827469e-05
## ASV7809     -1.848065e-05 -1.933905e-05 -2.023451e-05 -2.116828e-05
## ASV8002     -1.258732e-04 -1.316522e-04 -1.376844e-04 -1.439796e-04
## ASV8205      6.597208e-05  6.872000e-05  7.156571e-05  7.451130e-05
## ASV9155     -9.550971e-05 -9.990765e-05 -1.044989e-04 -1.092909e-04
## ASV9221     -2.022522e-05 -2.128453e-05 -2.240081e-05 -2.357710e-05
## ASV9311     -1.258575e-04 -1.316350e-04 -1.376655e-04 -1.439589e-04
## ASV9557     -1.258472e-04 -1.316238e-04 -1.376532e-04 -1.439454e-04
## ASV9936     -1.258369e-04 -1.316125e-04 -1.376409e-04 -1.439319e-04
## ASV1445      2.832820e-04  2.962423e-04  3.097714e-04  3.238922e-04
## ASV4232      2.369284e-04  2.477997e-04  2.591525e-04  2.710069e-04
## ASV6479     -2.458459e-06 -2.391291e-06 -2.302759e-06 -2.190094e-06
## ASV0142     -6.171050e-04 -6.443356e-04 -6.726708e-04 -7.021468e-04
## ASV0378     -2.029552e-04 -2.118412e-04 -2.210810e-04 -2.306854e-04
## ASV1122      3.729635e-04  3.899763e-04  4.077313e-04  4.262578e-04
## ASV0123     -6.049047e-04 -6.315983e-04 -6.593747e-04 -6.882696e-04
## ASV2064      6.015238e-05  6.261891e-05  6.517087e-05  6.781002e-05
## ASV4459     -7.104609e-05 -7.437216e-05 -7.784898e-05 -8.148277e-05
## ASV0448      1.125182e-04  1.181838e-04  1.241428e-04  1.304105e-04
## ASV0397      2.823977e-04  2.953441e-04  3.088587e-04  3.229640e-04
## ASV0485      3.920669e-04  4.097469e-04  4.281777e-04  4.473872e-04
## ASV1566      3.239275e-04  3.384711e-04  3.536281e-04  3.694211e-04
## ASV1365      2.085411e-04  2.178633e-04  2.275753e-04  2.376910e-04
## ASV1065      4.347431e-04  4.544840e-04  4.750755e-04  4.965500e-04
## ASV0722     -6.927010e-06 -7.103724e-06 -7.277438e-06 -7.447330e-06
## ASV12660    -2.082935e-04 -2.176633e-04 -2.274278e-04 -2.376012e-04
## ASV0223     -3.014279e-06 -2.897018e-06 -2.752447e-06 -2.577624e-06
## ASV0229      1.964505e-04  2.055547e-04  2.150674e-04  2.250056e-04
## ASV0877     -7.729602e-05 -8.075619e-05 -8.436001e-05 -8.811237e-05
## ASV0983      4.003367e-04  4.183208e-04  4.370620e-04  4.565876e-04
## ASV0626     -1.304188e-04 -1.358905e-04 -1.415573e-04 -1.474232e-04
## ASV4146     -2.489523e-05 -2.611080e-05 -2.738494e-05 -2.872026e-05
## ASV4175     -2.466988e-04 -2.579545e-04 -2.696989e-04 -2.819510e-04
## ASV2082     -1.405664e-05 -1.469089e-05 -1.535399e-05 -1.604742e-05
## ASV2272      1.755098e-04  1.835059e-04  1.918511e-04  2.005594e-04
## ASV2245     -2.140410e-04 -2.238144e-04 -2.340126e-04 -2.446521e-04
## ASV0590     -1.262572e-04 -1.321080e-04 -1.382230e-04 -1.446133e-04
## ASV0217     -1.926714e-04 -2.004020e-04 -2.083740e-04 -2.165887e-04
## ASV0416      2.006759e-04  2.094491e-04  2.185691e-04  2.280461e-04
## ASV1056      2.372542e-04  2.483487e-04  2.599514e-04  2.720847e-04
## ASV7777     -2.156313e-04 -2.256057e-04 -2.360259e-04 -2.469100e-04
## ASV0455      4.464943e-05  4.685355e-05  4.916723e-05  5.159574e-05
## ASV0604      4.892148e-05  5.152712e-05  5.428049e-05  5.719047e-05
## ASV6100     -2.004239e-04 -2.097752e-04 -2.195518e-04 -2.297718e-04
## ASV11359    -2.199797e-04 -2.299674e-04 -2.403840e-04 -2.512458e-04
## ASV6604      1.564005e-04  1.636790e-04  1.712894e-04  1.792463e-04
## ASV5004     -1.314766e-04 -1.375422e-04 -1.438766e-04 -1.504903e-04
## ASV1483     -1.200611e-04 -1.255684e-04 -1.313168e-04 -1.373159e-04
## ASV9773     -2.548936e-04 -2.666834e-04 -2.790003e-04 -2.918661e-04
## ASV4059      2.532799e-05  2.671508e-05  2.818540e-05  2.974449e-05
## ASV1193      4.089676e-04  4.276056e-04  4.470557e-04  4.673498e-04
## ASV4610     -3.795527e-05 -3.946309e-05 -4.101534e-05 -4.261174e-05
## ASV0742     -1.539368e-04 -1.605530e-04 -1.674204e-04 -1.745456e-04
## ASV1502     -2.473531e-06 -2.708671e-06 -2.963442e-06 -3.239217e-06
## ASV0195     -4.405599e-05 -4.620573e-05 -4.846244e-05 -5.083158e-05
## ASV1213      1.323947e-04  1.383292e-04  1.445118e-04  1.509512e-04
## ASV1648     -1.893023e-04 -1.980655e-04 -2.072212e-04 -2.167856e-04
## ASV6984     -1.402608e-04 -1.467138e-04 -1.534513e-04 -1.604847e-04
## ASV0396     -9.947357e-05 -1.031735e-04 -1.069609e-04 -1.108331e-04
## ASV4297      2.076864e-04  2.168104e-04  2.263015e-04  2.361717e-04
## ASV2622      4.750497e-04  4.961690e-04  5.181597e-04  5.410517e-04
## ASV3512      7.107573e-05  7.446321e-05  7.801330e-05  8.173396e-05
## ASV2411      1.649240e-04  1.726475e-04  1.807255e-04  1.891735e-04
## ASV2291     -3.744527e-05 -3.912270e-05 -4.087186e-05 -4.269563e-05
## ASV0807      1.971101e-04  2.066925e-04  2.167448e-04  2.272901e-04
## ASV1292      1.117384e-04  1.169088e-04  1.223108e-04  1.279537e-04
## ASV1035      5.036177e-05  5.250326e-05  5.472305e-05  5.702276e-05
## ASV0070     -1.138918e-04 -1.187632e-04 -1.238185e-04 -1.290624e-04
## ASV0255      4.412049e-05  4.601178e-05  4.797265e-05  5.000444e-05
## ASV0057     -4.890102e-04 -5.103964e-04 -5.326314e-04 -5.557412e-04
## ASV0077     -7.242739e-05 -7.544363e-05 -7.856678e-05 -8.179908e-05
## ASV0625      4.922102e-04  5.141885e-04  5.370812e-04  5.609203e-04
## ASV2464      2.407406e-04  2.514677e-04  2.626381e-04  2.742670e-04
## ASV1315      4.191005e-04  4.381828e-04  4.580960e-04  4.788731e-04
## ASV2673      3.133837e-04  3.280911e-04  3.434770e-04  3.595718e-04
## ASV2161      1.269694e-04  1.328668e-04  1.390322e-04  1.454772e-04
## ASV0337     -2.066330e-04 -2.160410e-04 -2.258584e-04 -2.361016e-04
## ASV7680     -2.414752e-04 -2.525038e-04 -2.640124e-04 -2.760198e-04
## ASV0611      5.216099e-04  5.454961e-04  5.704327e-04  5.964619e-04
## ASV3118     -1.791460e-04 -1.874075e-04 -1.960355e-04 -2.050449e-04
## ASV1284      1.949473e-04  2.041646e-04  2.138090e-04  2.238988e-04
## ASV0889      1.417984e-04  1.481130e-04  1.546900e-04  1.615385e-04
## ASV4649     -1.529504e-04 -1.600504e-04 -1.674700e-04 -1.752224e-04
## ASV1108     -1.943588e-04 -2.035645e-04 -2.132012e-04 -2.232883e-04
## ASV0738     -2.395171e-05 -2.421644e-05 -2.441782e-05 -2.454670e-05
## ASV0473      3.038503e-05  3.180966e-05  3.329924e-05  3.485651e-05
## ASV0598     -2.172774e-04 -2.268131e-04 -2.367307e-04 -2.470422e-04
## ASV0429      3.455799e-04  3.611171e-04  3.773107e-04  3.941847e-04
## ASV1549      3.479274e-04  3.642571e-04  3.813412e-04  3.992133e-04
## ASV1203      2.595382e-04  2.711674e-04  2.832836e-04  2.959042e-04
## ASV4532      1.100382e-05  1.140281e-05  1.181141e-05  1.222954e-05
## ASV0274     -2.586574e-04 -2.698413e-04 -2.814593e-04 -2.935240e-04
## ASV0163     -3.722728e-04 -3.884363e-04 -4.052310e-04 -4.226751e-04
## ASV1298      1.522088e-04  1.588475e-04  1.657474e-04  1.729162e-04
## ASV9424     -3.227792e-04 -3.377118e-04 -3.533128e-04 -3.696099e-04
## ASV0412      4.926992e-04  5.149168e-04  5.380785e-04  5.622195e-04
## ASV0284      2.186597e-04  2.282138e-04  2.381454e-04  2.484658e-04
## ASV0620     -1.664428e-04 -1.743127e-04 -1.825491e-04 -1.911683e-04
## ASV0153     -3.413759e-04 -3.571274e-04 -3.735827e-04 -3.907713e-04
## ASV0498      3.944744e-05  4.177048e-05  4.423973e-05  4.686462e-05
## ASV0097      2.425326e-04  2.536756e-04  2.653118e-04  2.774611e-04
## ASV0104     -1.129196e-03 -1.180212e-03 -1.233409e-03 -1.288869e-03
## ASV1282      1.996515e-04  2.088987e-04  2.185597e-04  2.286518e-04
## ASV3883     -1.114352e-04 -1.164760e-04 -1.217306e-04 -1.272066e-04
## ASV0801      1.180196e-04  1.238102e-04  1.298894e-04  1.362718e-04
## ASV1611     -4.334412e-04 -4.531687e-04 -4.737505e-04 -4.952196e-04
## ASV0227     -1.537602e-04 -1.608675e-04 -1.682928e-04 -1.760492e-04
## ASV0833      1.706419e-04  1.787733e-04  1.872902e-04  1.962105e-04
## ASV0718      4.098356e-04  4.286785e-04  4.483565e-04  4.689037e-04
## ASV1139      1.535994e-04  1.604479e-04  1.675800e-04  1.750054e-04
## ASV0766     -1.091714e-04 -1.139457e-04 -1.189085e-04 -1.240652e-04
## ASV2091      5.397119e-04  5.634211e-04  5.880834e-04  6.137292e-04
## ASV1238     -2.761769e-05 -2.827988e-05 -2.892023e-05 -2.953379e-05
## ASV9193     -5.910331e-05 -6.246991e-05 -6.603847e-05 -6.982116e-05
## ASV0290     -4.190559e-05 -4.382430e-05 -4.582645e-05 -4.791519e-05
## ASV0231      4.264836e-04  4.455525e-04  4.654165e-04  4.861036e-04
## ASV0185      8.243342e-05  8.734513e-05  9.257475e-05  9.814400e-05
## ASV2330      1.240608e-04  1.295709e-04  1.353082e-04  1.412804e-04
## ASV3119     -1.434664e-04 -1.504577e-04 -1.577933e-04 -1.654901e-04
## ASV2368     -1.986988e-04 -2.080293e-04 -2.177900e-04 -2.280001e-04
## ASV0122     -1.562101e-04 -1.631724e-04 -1.704255e-04 -1.779801e-04
## ASV1044      2.735318e-04  2.866016e-04  3.002961e-04  3.146450e-04
## ASV0160     -3.784025e-04 -3.947886e-04 -4.118111e-04 -4.294885e-04
## ASV0326      2.463787e-04  2.575648e-04  2.692335e-04  2.814034e-04
## ASV1388      4.311879e-04  4.506418e-04  4.709244e-04  4.920666e-04
## ASV0792      4.943390e-04  5.166722e-04  5.399587e-04  5.642340e-04
## ASV0036     -3.126149e-04 -3.271504e-04 -3.423454e-04 -3.582284e-04
## ASV2125      5.074101e-04  5.304463e-04  5.544773e-04  5.795416e-04
## ASV1075      9.695802e-05  1.015071e-04  1.062675e-04  1.112490e-04
## ASV0390      1.000860e-04  1.051964e-04  1.105802e-04  1.162529e-04
## ASV3790     -3.976255e-04 -4.153902e-04 -4.338949e-04 -4.531657e-04
## ASV1535     -3.383239e-05 -3.549750e-05 -3.724404e-05 -3.907568e-05
## ASV0263      8.661457e-05  9.068439e-05  9.494197e-05  9.939556e-05
## ASV0675      6.735378e-04  7.049750e-04  7.378465e-04  7.722142e-04
## ASV3348      6.553131e-05  6.873222e-05  7.209261e-05  7.562065e-05
## ASV0058     -6.337618e-04 -6.621702e-04 -6.917732e-04 -7.226142e-04
## ASV4142      1.562660e-04  1.631320e-04  1.702742e-04  1.777015e-04
## ASV0059     -5.462487e-04 -5.706799e-04 -5.961337e-04 -6.226467e-04
## ASV0013     -1.144833e-03 -1.196479e-03 -1.250326e-03 -1.306456e-03
## ASV0033     -3.410020e-04 -3.569115e-04 -3.735476e-04 -3.909421e-04
## ASV4354     -1.473325e-04 -1.538765e-04 -1.606893e-04 -1.677802e-04
## ASV0022     -3.600688e-04 -3.768544e-04 -3.944053e-04 -4.127547e-04
## ASV0134     -9.171663e-05 -9.625127e-05 -1.010162e-04 -1.060236e-04
## ASV0415     -7.385864e-05 -7.681176e-05 -7.985743e-05 -8.299630e-05
## ASV10103    -2.491589e-04 -2.605566e-04 -2.724532e-04 -2.848683e-04
## ASV1613      4.054657e-04  4.237587e-04  4.428314e-04  4.627131e-04
## ASV0135     -2.487630e-05 -2.568630e-05 -2.650133e-05 -2.731878e-05
## ASV0469     -5.037471e-04 -5.262996e-04 -5.497964e-04 -5.742714e-04
## ASV0471      3.245378e-04  3.395527e-04  3.552392e-04  3.716251e-04
## ASV0451     -8.697313e-05 -9.114166e-05 -9.551140e-05 -1.000922e-04
## ASV0747      1.206897e-04  1.262557e-04  1.320685e-04  1.381382e-04
## ASV1314     -1.922646e-04 -2.014069e-04 -2.109808e-04 -2.210063e-04
## ASV0425     -5.687602e-04 -5.938285e-04 -6.199118e-04 -6.470435e-04
## ASV0559     -3.203629e-04 -3.342994e-04 -3.487829e-04 -3.638299e-04
## ASV0148     -3.501057e-04 -3.654367e-04 -3.813795e-04 -3.979533e-04
## ASV0129     -1.737363e-04 -1.810763e-04 -1.886857e-04 -1.965710e-04
## ASV1072      1.684197e-04  1.756871e-04  1.832355e-04  1.910732e-04
## ASV2390      1.227093e-04  1.281212e-04  1.337522e-04  1.396093e-04
## ASV0548      3.700480e-04  3.870718e-04  4.048523e-04  4.234208e-04
## ASV0168     -5.494889e-04 -5.739226e-04 -5.993659e-04 -6.258541e-04
## ASV0066     -4.125166e-04 -4.311909e-04 -4.506669e-04 -4.709753e-04
## ASV0468     -1.578575e-04 -1.653121e-04 -1.731149e-04 -1.812819e-04
## ASV0172     -8.514247e-05 -8.848510e-05 -9.192662e-05 -9.546704e-05
## ASV0236     -2.098058e-04 -2.184835e-04 -2.274610e-04 -2.367434e-04
## ASV0250      1.408227e-05  1.560642e-05  1.727422e-05  1.909783e-05
## ASV0338     -2.307367e-05 -2.338215e-05 -2.363945e-05 -2.383821e-05
## ASV0450      9.981357e-07  1.186206e-06  1.395265e-06  1.627258e-06
## ASV0377      4.536758e-04  4.743454e-04  4.959136e-04  5.184157e-04
## ASV1022      1.289362e-04  1.349744e-04  1.412901e-04  1.478957e-04
## ASV6174     -2.849229e-05 -2.960781e-05 -3.075436e-05 -3.193147e-05
## ASV0786      5.183651e-05  5.411941e-05  5.649393e-05  5.896291e-05
## ASV0053     -5.445022e-04 -5.693179e-04 -5.952138e-04 -6.222325e-04
## ASV0697     -1.566676e-04 -1.634762e-04 -1.705522e-04 -1.779037e-04
## ASV0785      4.047074e-04  4.231251e-04  4.423445e-04  4.623974e-04
## ASV1967     -2.700081e-04 -2.820443e-04 -2.945795e-04 -3.076311e-04
## ASV0385     -1.225874e-04 -1.278191e-04 -1.332496e-04 -1.388845e-04
## ASV0295      1.396888e-07  5.039558e-07  9.162689e-07  1.381348e-06
## ASV0072     -4.321479e-04 -4.512681e-04 -4.711706e-04 -4.918818e-04
## ASV0157     -1.752872e-04 -1.826266e-04 -1.902252e-04 -1.980875e-04
## ASV0501      2.009594e-04  2.104838e-04  2.204516e-04  2.308823e-04
## ASV10729    -3.332345e-04 -3.485738e-04 -3.645934e-04 -3.813207e-04
## ASV1470      1.480746e-04  1.542621e-04  1.606707e-04  1.673052e-04
## ASV0050     -1.080391e-03 -1.128878e-03 -1.179410e-03 -1.232058e-03
## ASV0411     -2.962727e-05 -3.088136e-05 -3.218379e-05 -3.353624e-05
## ASV0549      2.071825e-04  2.169324e-04  2.271365e-04  2.378156e-04
## ASV0184      1.280127e-04  1.338759e-04  1.399968e-04  1.463859e-04
## ASV0705      1.561034e-04  1.634807e-04  1.712019e-04  1.792824e-04
## ASV1715      3.848537e-04  4.023886e-04  4.206864e-04  4.397773e-04
## ASV0603      4.918044e-05  5.164243e-05  5.423200e-05  5.695606e-05
## ASV0826      1.284344e-04  1.340730e-04  1.399375e-04  1.460351e-04
## ASV0034     -4.908479e-04 -5.128242e-04 -5.357201e-04 -5.595685e-04
## ASV0838      1.155724e-04  1.213136e-04  1.273449e-04  1.336807e-04
## ASV0614     -2.844597e-04 -2.974992e-04 -3.111132e-04 -3.253249e-04
## ASV0014     -1.047930e-03 -1.095032e-03 -1.144125e-03 -1.195283e-03
## ASV0585     -6.068838e-05 -6.323978e-05 -6.588350e-05 -6.862161e-05
## ASV0016     -1.071602e-03 -1.119805e-03 -1.170049e-03 -1.222409e-03
## ASV5394     -2.758174e-04 -2.885570e-04 -3.018656e-04 -3.157667e-04
## ASV0666      2.329695e-04  2.435199e-04  2.545226e-04  2.659947e-04
## ASV2085      9.123468e-05  9.490276e-05  9.868693e-05  1.025880e-04
## ASV0003     -9.800633e-04 -1.024054e-03 -1.069898e-03 -1.117665e-03
## ASV0346     -1.668266e-05 -1.687356e-05 -1.702215e-05 -1.712243e-05
## ASV0267     -1.593004e-04 -1.664062e-04 -1.738071e-04 -1.815136e-04
## ASV0353      2.139515e-04  2.243032e-04  2.351563e-04  2.465344e-04
## ASV2419      2.780585e-04  2.905414e-04  3.035508e-04  3.171057e-04
## ASV0447      1.329120e-04  1.395226e-04  1.464699e-04  1.537713e-04
## ASV0654      4.278313e-04  4.473655e-04  4.677518e-04  4.890236e-04
## ASV0151      6.695693e-05  7.033498e-05  7.389054e-05  7.763341e-05
## ASV0065     -3.959430e-04 -4.137970e-04 -4.324122e-04 -4.518173e-04
## ASV0527      2.900561e-04  3.033068e-04  3.171372e-04  3.315702e-04
## ASV4055     -1.139870e-04 -1.196289e-04 -1.255578e-04 -1.317887e-04
## ASV0166     -3.216133e-04 -3.354706e-04 -3.498606e-04 -3.647982e-04
## ASV0417     -2.781549e-04 -2.905705e-04 -3.035029e-04 -3.169702e-04
## ASV0078     -2.227343e-04 -2.325603e-04 -2.427859e-04 -2.534245e-04
## ASV0322     -2.662265e-04 -2.777399e-04 -2.897005e-04 -3.021213e-04
## ASV0156     -3.445367e-04 -3.595146e-04 -3.750810e-04 -3.912537e-04
## ASV0648     -3.228564e-04 -3.378308e-04 -3.534794e-04 -3.698306e-04
## ASV0407      1.800240e-05  1.865225e-05  1.931582e-05  1.999247e-05
## ASV2030     -6.715396e-05 -6.994706e-05 -7.283736e-05 -7.582649e-05
## ASV0300      1.931530e-04  2.025538e-04  2.124161e-04  2.227624e-04
## ASV1150     -2.725171e-05 -2.849157e-05 -2.978487e-05 -3.113363e-05
## ASV0958      1.980461e-04  2.075392e-04  2.174884e-04  2.279157e-04
## ASV0216     -3.392103e-04 -3.543166e-04 -3.700474e-04 -3.864241e-04
## ASV0446      4.720229e-04  4.941524e-04  5.172993e-04  5.415080e-04
## ASV0367     -1.602296e-04 -1.674452e-04 -1.749672e-04 -1.828068e-04
## ASV0200     -2.939802e-04 -3.071144e-04 -3.207988e-04 -3.350534e-04
## ASV0334     -1.482709e-04 -1.541213e-04 -1.601450e-04 -1.663418e-04
## ASV1311      2.178999e-04  2.280133e-04  2.385843e-04  2.496323e-04
## ASV0458      2.287780e-04  2.391232e-04  2.499116e-04  2.611600e-04
## ASV1371      3.557794e-06  3.580721e-06  3.591808e-06  3.589415e-06
## ASV0418      2.688763e-04  2.806498e-04  2.928934e-04  3.056218e-04
## ASV0004      3.274057e-04  3.420861e-04  3.573840e-04  3.733216e-04
## ASV1943      2.402449e-04  2.509073e-04  2.620084e-04  2.735634e-04
## ASV1495     -5.967808e-05 -6.270760e-05 -6.589689e-05 -6.925470e-05
## ASV0901     -3.789871e-04 -3.965833e-04 -4.149754e-04 -4.341974e-04
## ASV0628      2.227915e-04  2.328593e-04  2.433579e-04  2.543037e-04
## ASV0400      8.745943e-05  9.131641e-05  9.532807e-05  9.949913e-05
## ASV0116     -2.826392e-04 -2.954787e-04 -3.088735e-04 -3.228452e-04
## ASV0788      2.378475e-04  2.486170e-04  2.598486e-04  2.715600e-04
## ASV0117      1.536947e-04  1.609395e-04  1.685219e-04  1.764573e-04
## ASV3137      4.255571e-05  4.448248e-05  4.649271e-05  4.858977e-05
## ASV0001      3.991065e-04  4.169243e-04  4.354857e-04  4.548172e-04
## ASV1651      2.553356e-04  2.662082e-04  2.774853e-04  2.891767e-04
## ASV1692      2.847351e-04  2.980890e-04  3.120581e-04  3.266698e-04
## ASV0660      1.615598e-04  1.685382e-04  1.757837e-04  1.833032e-04
## ASV0508      2.146879e-05  2.238307e-05  2.333113e-05  2.431373e-05
## ASV1660     -1.150889e-04 -1.204753e-04 -1.261079e-04 -1.319973e-04
## ASV0233      6.488785e-05  6.798051e-05  7.122104e-05  7.461656e-05
## ASV1343     -2.847176e-04 -2.977572e-04 -3.113695e-04 -3.255776e-04
## ASV0209      2.682625e-04  2.803365e-04  2.929232e-04  3.060420e-04
## ASV0193     -3.333672e-04 -3.478113e-04 -3.628188e-04 -3.784062e-04
## ASV0357     -2.576605e-05 -2.690465e-05 -2.808799e-05 -2.931718e-05
## ASV0198      7.676214e-05  8.043679e-05  8.428626e-05  8.831864e-05
## ASV0007      3.790424e-04  3.959975e-04  4.136632e-04  4.320652e-04
## ASV1772     -3.739713e-05 -3.901561e-05 -4.069648e-05 -4.244145e-05
## ASV0009      3.579861e-04  3.739947e-04  3.906739e-04  4.080480e-04
## ASV0006      1.435079e-04  1.496478e-04  1.560199e-04  1.626303e-04
## ASV0011     -3.985095e-04 -4.168622e-04 -4.360299e-04 -4.560460e-04
## ASV0015      2.759564e-04  2.883828e-04  3.013366e-04  3.148373e-04
## ASV0017      2.922412e-04  3.053822e-04  3.190793e-04  3.333531e-04
## ASV0235     -2.302313e-04 -2.406955e-04 -2.516106e-04 -2.629936e-04
## ASV0382      4.483035e-05  4.742153e-05  5.017346e-05  5.309647e-05
## ASV2357      3.510328e-04  3.669709e-04  3.835967e-04  4.009365e-04
## ASV0567     -2.566824e-04 -2.682330e-04 -2.802740e-04 -2.928239e-04
## ASV0165      2.824909e-04  2.953896e-04  3.088508e-04  3.228966e-04
## ASV0005      5.596413e-04  5.845493e-04  6.104876e-04  6.374922e-04
## ASV0384     -2.983630e-05 -3.109618e-05 -3.240196e-05 -3.375466e-05
## ASV0002      1.185841e-04  1.240492e-04  1.297574e-04  1.357185e-04
## ASV3017      3.278666e-04  3.424349e-04  3.576037e-04  3.733936e-04
## ASV0091      1.259982e-04  1.317957e-04  1.378497e-04  1.441707e-04
## ASV0186     -3.360265e-04 -3.512038e-04 -3.670285e-04 -3.835247e-04
## ASV0370      3.668371e-05  3.852375e-05  4.045999e-05  4.249781e-05
## ASV0018      5.830333e-04  6.090358e-04  6.361189e-04  6.643206e-04
## ASV1377      5.123445e-04  5.352741e-04  5.591623e-04  5.840434e-04
## ASV0019      5.838414e-04  6.098875e-04  6.370168e-04  6.652674e-04
## ASV0023      4.164852e-05  4.317469e-05  4.473475e-05  4.632731e-05
## ASV2194      1.883935e-04  1.969542e-04  2.058874e-04  2.152082e-04
## ASV1155     -1.788088e-05 -1.833575e-05 -1.877803e-05 -1.920439e-05
## ASV0510     -2.100245e-04 -2.188060e-04 -2.279005e-04 -2.373144e-04
## ASV2371     -2.117179e-04 -2.209612e-04 -2.305699e-04 -2.405552e-04
## ASV0024      1.343038e-05  1.367518e-05  1.389852e-05  1.409683e-05
## ASV2452      2.765858e-04  2.888482e-04  3.016140e-04  3.149003e-04
## ASV2332      5.114138e-06  5.342476e-06  5.581743e-06  5.832650e-06
## ASV2591      1.134690e-05  1.219500e-05  1.310960e-05  1.409590e-05
## ASV0521      3.856004e-04  4.037781e-04  4.228002e-04  4.427046e-04
## ASV5542      1.154753e-04  1.208476e-04  1.264633e-04  1.323327e-04
## ASV0336     -1.694828e-04 -1.767893e-04 -1.843773e-04 -1.922547e-04
## ASV10102     2.603128e-04  2.721769e-04  2.845562e-04  2.974709e-04
## ASV16823    -2.072881e-04 -2.163884e-04 -2.258534e-04 -2.356947e-04
## ASV3104      2.072719e-04  2.163708e-04  2.258342e-04  2.356738e-04
## ASV0781      1.028848e-04  1.076684e-04  1.126689e-04  1.178959e-04
## ASV10899     9.512916e-05  9.977107e-05  1.046425e-04  1.097548e-04
## ASV11222    -2.072611e-04 -2.163591e-04 -2.258215e-04 -2.356600e-04
## ASV11327    -2.072449e-04 -2.163415e-04 -2.258023e-04 -2.356391e-04
## ASV12458    -2.072287e-04 -2.163238e-04 -2.257831e-04 -2.356182e-04
## ASV1636     -1.678410e-04 -1.751142e-04 -1.826698e-04 -1.905161e-04
## ASV1890     -2.058203e-04 -2.148928e-04 -2.243324e-04 -2.341509e-04
## ASV2898      4.461011e-04  4.662233e-04  4.872018e-04  5.090686e-04
## ASV8328     -3.422867e-05 -3.533666e-05 -3.645222e-05 -3.757205e-05
## ASV0709     -3.614010e-04 -3.776005e-04 -3.944801e-04 -4.120644e-04
## ASV0856      6.027581e-05  6.327901e-05  6.643659e-05  6.975680e-05
## ASV0909     -1.509997e-04 -1.572383e-04 -1.636909e-04 -1.703609e-04
## ASV0937     -2.826899e-04 -2.955529e-04 -3.089737e-04 -3.229740e-04
## ASV11390    -2.071943e-04 -2.162864e-04 -2.257424e-04 -2.355740e-04
## ASV11966     1.016641e-04  1.063525e-04  1.112490e-04  1.163622e-04
## ASV12990     5.724110e-05  5.994481e-05  6.277480e-05  6.573682e-05
## ASV14797     2.142728e-04  2.238543e-04  2.338361e-04  2.442323e-04
## ASV14904    -2.071897e-04 -2.162814e-04 -2.257370e-04 -2.355681e-04
## ASV15304     5.230783e-05  5.480820e-05  5.742718e-05  6.017020e-05
## ASV16696    -2.071760e-04 -2.162666e-04 -2.257209e-04 -2.355506e-04
## ASV1690      1.056069e-04  1.106613e-04  1.159567e-04  1.215045e-04
## ASV2029      5.708648e-04  5.966449e-04  6.235245e-04  6.515448e-04
## ASV2834      3.024552e-04  3.160743e-04  3.302702e-04  3.450640e-04
## ASV4003      8.914202e-05  9.367580e-05  9.845023e-05  1.034787e-04
## ASV4064      2.085314e-04  2.179086e-04  2.276819e-04  2.378657e-04
## ASV4294      7.659742e-05  8.051007e-05  8.463202e-05  8.897510e-05
## ASV4609     -1.027039e-05 -1.070755e-05 -1.116042e-05 -1.162924e-05
## ASV6283     -2.071737e-04 -2.162642e-04 -2.257185e-04 -2.355481e-04
## ASV6491     -2.071575e-04 -2.162465e-04 -2.256993e-04 -2.355273e-04
## ASV7453      8.240966e-05  8.650915e-05  9.081732e-05  9.534493e-05
## ASV7959      1.439988e-05  1.528803e-05  1.623528e-05  1.724569e-05
## ASV8219      2.071461e-04  2.162341e-04  2.256859e-04  2.355128e-04
## ASV8547     -2.071299e-04 -2.162165e-04 -2.256667e-04 -2.354919e-04
## ASV9319      1.365146e-04  1.427125e-04  1.491774e-04  1.559192e-04
## ASV9382     -2.071197e-04 -2.162055e-04 -2.256547e-04 -2.354788e-04
## ASV11516    -2.071036e-04 -2.161879e-04 -2.256355e-04 -2.354579e-04
## ASV14377    -2.070874e-04 -2.161703e-04 -2.256163e-04 -2.354371e-04
## ASV1867      3.031573e-04  3.171347e-04  3.317349e-04  3.469837e-04
## ASV1895     -7.099376e-05 -7.409940e-05 -7.732885e-05 -8.068604e-05
## ASV3168      1.274011e-04  1.330492e-04  1.389285e-04  1.450466e-04
## ASV4449      2.576244e-04  2.690625e-04  2.809710e-04  2.933660e-04
## ASV6596      1.518194e-04  1.592637e-04  1.670809e-04  1.752901e-04
## ASV7492     -7.770069e-05 -8.086899e-05 -8.414172e-05 -8.752009e-05
## ASV9854     -1.061408e-04 -1.107016e-04 -1.154359e-04 -1.203483e-04
## ASV6296      2.070533e-04  2.161332e-04  2.255761e-04  2.353934e-04
## ASV4201      6.793306e-05  7.149135e-05  7.524631e-05  7.920938e-05
## ASV0552      5.082262e-04  5.317152e-04  5.562546e-04  5.818879e-04
## ASV3671     -4.062297e-05 -4.208254e-05 -4.356992e-05 -4.508302e-05
## ASV3529     -4.734894e-05 -4.921120e-05 -5.112832e-05 -5.310020e-05
## ASV1060      1.296716e-04  1.357739e-04  1.421602e-04  1.488436e-04
## ASV0239     -2.815177e-04 -2.936007e-04 -3.061421e-04 -3.191538e-04
## ASV5711     -2.641963e-04 -2.758488e-04 -2.879733e-04 -3.005853e-04
## ASV4152     -3.470827e-04 -3.625195e-04 -3.785932e-04 -3.953257e-04
## ASV1461      3.110482e-04  3.247595e-04  3.390258e-04  3.538650e-04
## ASV2877      2.519403e-04  2.631782e-04  2.748827e-04  2.870702e-04
## ASV0012      1.888251e-04  1.975272e-04  2.066161e-04  2.161076e-04
## ASV9823      5.921183e-05  6.134806e-05  6.353013e-05  6.575613e-05
## ASV0008      2.062780e-04  2.157309e-04  2.255994e-04  2.359001e-04
## ASV7832     -2.162382e-04 -2.259053e-04 -2.359758e-04 -2.464641e-04
## ASV1915      1.707366e-05  1.802086e-05  1.902393e-05  2.008629e-05
## ASV0055      1.482018e-04  1.549114e-04  1.619084e-04  1.692038e-04
## ASV0032      3.639723e-04  3.804972e-04  3.977360e-04  4.157166e-04
## ASV2977     -2.925800e-04 -3.056001e-04 -3.191581e-04 -3.332723e-04
## ASV0466      2.946452e-04  3.075141e-04  3.208923e-04  3.347956e-04
## ASV3866      3.160479e-04  3.305999e-04  3.457984e-04  3.616699e-04
## ASV0040      4.144775e-04  4.334065e-04  4.531616e-04  4.737752e-04
## ASV0496     -2.414267e-05 -2.564161e-05 -2.724190e-05 -2.895072e-05
## ASV0052      5.060329e-04  5.287042e-04  5.523264e-04  5.769336e-04
## ASV3828     -3.163543e-04 -3.306331e-04 -3.455214e-04 -3.610420e-04
## ASV1930      1.976510e-04  2.067473e-04  2.162464e-04  2.261646e-04
## ASV2126      3.188671e-04  3.333385e-04  3.484343e-04  3.641786e-04
## ASV0793      1.864487e-04  1.950588e-04  2.040544e-04  2.134517e-04
## ASV0299     -1.320674e-04 -1.376389e-04 -1.434116e-04 -1.493898e-04
## ASV0208      3.032856e-04  3.176636e-04  3.327171e-04  3.484772e-04
## ASV0511     -1.590306e-04 -1.657051e-04 -1.726185e-04 -1.797754e-04
## ASV1123     -2.084592e-04 -2.173711e-04 -2.266179e-04 -2.362082e-04
## ASV0099     -1.118731e-04 -1.166396e-04 -1.215835e-04 -1.267092e-04
## ASV0752     -2.491176e-05 -2.626074e-05 -2.768794e-05 -2.919818e-05
## ASV0883      1.439348e-06  1.535258e-06  1.638436e-06  1.749498e-06
## ASV0683      2.689403e-04  2.815999e-04  2.948475e-04  3.087096e-04
## ASV4117     -3.124358e-04 -3.262699e-04 -3.406691e-04 -3.556520e-04
## ASV2172      1.169819e-04  1.222888e-04  1.278250e-04  1.335992e-04
## ASV0330     -2.145467e-04 -2.243914e-04 -2.346723e-04 -2.454074e-04
## ASV0728      1.922269e-04  2.006973e-04  2.095114e-04  2.186805e-04
## ASV0499      4.067551e-04  4.259239e-04  4.459845e-04  4.669775e-04
## ASV0120     -4.425601e-04 -4.625576e-04 -4.834083e-04 -5.051440e-04
## ASV1446      3.703780e-05  3.845944e-05  3.991857e-05  4.141445e-05
## ASV17171    -3.009125e-04 -3.144738e-04 -3.286111e-04 -3.433459e-04
## ASV0533      8.631854e-05  9.041970e-05  9.471401e-05  9.921031e-05
## ASV2495     -1.204684e-04 -1.259664e-04 -1.317045e-04 -1.376922e-04
## ASV5582      1.040578e-04  1.084796e-04  1.130658e-04  1.178203e-04
## ASV1488      1.067200e-04  1.121187e-04  1.177964e-04  1.237675e-04
## ASV0682      2.836894e-04  2.970682e-04  3.110695e-04  3.257213e-04
## ASV0068     -1.577101e-05 -1.670003e-05 -1.768778e-05 -1.873808e-05
## ASV1987     -1.503022e-04 -1.574395e-04 -1.649133e-04 -1.727391e-04
## ASV0035      5.287748e-05  5.486689e-05  5.690401e-05  5.898715e-05
## ASV7192     -1.998722e-04 -2.085671e-04 -2.176027e-04 -2.269888e-04
## ASV0873      2.990099e-05  3.102346e-05  3.217369e-05  3.335100e-05
## ASV4749      1.885677e-05  1.939393e-05  1.992531e-05  2.044809e-05
## ASV2174      1.830421e-04  1.906596e-04  1.985477e-04  2.067122e-04
## ASV1476     -1.643400e-04 -1.717066e-04 -1.793829e-04 -1.873800e-04
## ASV0740     -4.076822e-04 -4.266457e-04 -4.464691e-04 -4.671893e-04
## ASV0170      8.668391e-05  9.064493e-05  9.477981e-05  9.909556e-05
## ASV2466     -3.709769e-04 -3.878887e-04 -4.055375e-04 -4.239524e-04
## ASV1709      2.854936e-04  2.983036e-04  3.116530e-04  3.255616e-04
## ASV6170     -2.422291e-04 -2.524467e-04 -2.630412e-04 -2.740221e-04
## ASV3673      2.900704e-04  3.029216e-04  3.163030e-04  3.302333e-04
## ASV1745      1.784283e-05  1.846048e-05  1.909007e-05  1.973110e-05
## ASV0380     -1.932004e-04 -2.012058e-04 -2.094941e-04 -2.180715e-04
## ASV0426     -5.855639e-05 -6.086043e-05 -6.323251e-05 -6.567253e-05
## ASV0202     -5.853337e-05 -6.044040e-05 -6.236191e-05 -6.429247e-05
## ASV6350     -2.434282e-04 -2.538245e-04 -2.646171e-04 -2.758174e-04
## ASV0713     -1.742479e-04 -1.820628e-04 -1.902078e-04 -1.986951e-04
## ASV1822      3.467453e-05  3.636012e-05  3.812608e-05  3.997589e-05
## ASV4569      2.817148e-04  2.942579e-04  3.073225e-04  3.209274e-04
## ASV0030     -6.326305e-05 -6.632271e-05 -6.953009e-05 -7.289210e-05
## ASV0331      1.176929e-04  1.234312e-04  1.294535e-04  1.357742e-04
## ASV2981      2.868591e-04  3.002010e-04  3.141453e-04  3.287173e-04
## ASV0828     -1.914811e-04 -2.005047e-04 -2.099465e-04 -2.198249e-04
## ASV2440      4.540739e-04  4.752130e-04  4.973110e-04  5.204090e-04
## ASV3006     -1.960625e-04 -2.042072e-04 -2.126417e-04 -2.213727e-04
## ASV3875     -1.960481e-04 -2.041916e-04 -2.126248e-04 -2.213544e-04
## ASV4511      1.143515e-04  1.198046e-04  1.255166e-04  1.314998e-04
## ASV4700     -1.960338e-04 -2.041761e-04 -2.126080e-04 -2.213362e-04
## ASV5804     -1.960194e-04 -2.041605e-04 -2.125911e-04 -2.213179e-04
## ASV6826      2.106304e-04  2.205705e-04  2.309744e-04  2.418631e-04
## ASV7280      1.739679e-04  1.820808e-04  1.905593e-04  1.994183e-04
## ASV7535     -1.960120e-04 -2.041525e-04 -2.125825e-04 -2.213087e-04
## ASV0651     -2.036260e-04 -2.126382e-04 -2.220174e-04 -2.317756e-04
## ASV0913      2.751789e-04  2.880669e-04  3.015485e-04  3.156500e-04
## ASV10832    -1.959983e-04 -2.041376e-04 -2.125665e-04 -2.212913e-04
## ASV1117     -3.897097e-04 -4.071243e-04 -4.252678e-04 -4.441664e-04
## ASV11329     9.666691e-05  1.017709e-04  1.071575e-04  1.128427e-04
## ASV13209    -1.140288e-05 -1.132700e-05 -1.119998e-05 -1.101635e-05
## ASV1345      4.802232e-05  5.032779e-05  5.274046e-05  5.526466e-05
## ASV1719     -1.959760e-04 -2.041136e-04 -2.125405e-04 -2.212633e-04
## ASV1886      2.249752e-04  2.350781e-04  2.456104e-04  2.565887e-04
## ASV2158     -5.304733e-05 -5.491559e-05 -5.682186e-05 -5.876463e-05
## ASV2189      2.410780e-04  2.520829e-04  2.635691e-04  2.755559e-04
## ASV2257      1.775220e-04  1.854075e-04  1.936201e-04  2.021714e-04
## ASV2283      1.959442e-04  2.040790e-04  2.125030e-04  2.212226e-04
## ASV2328      1.959298e-04  2.040634e-04  2.124861e-04  2.212043e-04
## ASV2434     -2.902941e-04 -3.030142e-04 -3.162468e-04 -3.300092e-04
## ASV2648      1.958985e-04  2.040295e-04  2.124493e-04  2.211643e-04
## ASV2698      2.830558e-04  2.960963e-04  3.097185e-04  3.239468e-04
## ASV2775      3.373979e-04  3.520156e-04  3.672038e-04  3.829795e-04
## ASV3171      1.958687e-04  2.039971e-04  2.124141e-04  2.211261e-04
## ASV3227      2.490165e-04  2.596848e-04  2.707583e-04  2.822480e-04
## ASV3397      1.513911e-05  1.588561e-05  1.666650e-05  1.748289e-05
## ASV3444      2.807521e-04  2.929389e-04  3.056069e-04  3.187714e-04
## ASV3556      1.958315e-04  2.039567e-04  2.123702e-04  2.210785e-04
## ASV3606     -1.958171e-04 -2.039411e-04 -2.123533e-04 -2.210603e-04
## ASV4190      2.485207e-04  2.598504e-04  2.716745e-04  2.840128e-04
## ASV4197      2.865767e-04  2.989193e-04  3.117384e-04  3.250478e-04
## ASV4722      2.587635e-04  2.703588e-04  2.824420e-04  2.950308e-04
## ASV4765      6.553114e-05  6.868070e-05  7.197886e-05  7.543206e-05
## ASV4809      1.957818e-04  2.039027e-04  2.123116e-04  2.210150e-04
## ASV4846      1.843591e-04  1.928661e-04  2.017510e-04  2.110292e-04
## ASV4903     -5.054701e-05 -5.219720e-05 -5.386634e-05 -5.555133e-05
## ASV4944     -1.957675e-04 -2.038873e-04 -2.122951e-04 -2.209972e-04
## ASV5151     -7.392655e-05 -7.779785e-05 -8.187866e-05 -8.618028e-05
## ASV5413     -1.957568e-04 -2.038758e-04 -2.122827e-04 -2.209838e-04
## ASV5537     -1.957424e-04 -2.038602e-04 -2.122658e-04 -2.209656e-04
## ASV5688      1.957281e-04  2.038447e-04  2.122490e-04  2.209473e-04
## ASV5752      9.267199e-05  9.707347e-05  1.016784e-04  1.064954e-04
## ASV6122     -1.957174e-04 -2.038331e-04 -2.122365e-04 -2.209338e-04
## ASV6135      1.957030e-04  2.038175e-04  2.122196e-04  2.209156e-04
## ASV6188     -1.956886e-04 -2.038020e-04 -2.122028e-04 -2.208974e-04
## ASV6216      2.891007e-04  3.016805e-04  3.147586e-04  3.283509e-04
## ASV6242      1.956584e-04  2.037691e-04  2.121670e-04  2.208586e-04
## ASV6383      1.956440e-04  2.037535e-04  2.121502e-04  2.208404e-04
## ASV6781      1.956297e-04  2.037380e-04  2.121334e-04  2.208222e-04
## ASV6799     -1.956153e-04 -2.037225e-04 -2.121165e-04 -2.208039e-04
## ASV7374     -1.956010e-04 -2.037069e-04 -2.120997e-04 -2.207857e-04
## ASV7539     -1.955866e-04 -2.036914e-04 -2.120829e-04 -2.207675e-04
## ASV8591     -1.955723e-04 -2.036758e-04 -2.120660e-04 -2.207493e-04
## ASV8637      1.955580e-04  2.036603e-04  2.120492e-04  2.207311e-04
## ASV12796    -1.955436e-04 -2.036448e-04 -2.120324e-04 -2.207128e-04
## ASV1934      2.257804e-04  2.361657e-04  2.470119e-04  2.583377e-04
## ASV22549     1.261620e-05  1.380239e-05  1.508996e-05  1.648657e-05
## ASV29857    -1.955299e-04 -2.036299e-04 -2.120164e-04 -2.206956e-04
## ASV3215      2.745301e-04  2.873000e-04  3.006496e-04  3.146039e-04
## ASV3236     -1.955146e-04 -2.036134e-04 -2.119984e-04 -2.206761e-04
## ASV3954     -1.955003e-04 -2.035978e-04 -2.119816e-04 -2.206579e-04
## ASV4850      1.954860e-04  2.035823e-04  2.119648e-04  2.206397e-04
## ASV5225      1.954716e-04  2.035668e-04  2.119480e-04  2.206215e-04
## ASV5532     -1.954573e-04 -2.035513e-04 -2.119312e-04 -2.206033e-04
## ASV7258      2.400064e-05  2.591882e-05  2.799063e-05  3.022774e-05
## ASV9474     -1.116032e-04 -1.159500e-04 -1.204263e-04 -1.250329e-04
## ASV11857    -1.954380e-04 -2.035305e-04 -2.119088e-04 -2.205793e-04
## ASV1202     -1.954237e-04 -2.035150e-04 -2.118920e-04 -2.205611e-04
## ASV14742     1.387507e-04  1.455960e-04  1.527841e-04  1.603322e-04
## ASV16652     7.046761e-05  7.389382e-05  7.748445e-05  8.124678e-05
## ASV2019      2.861115e-04  2.986775e-04  3.117512e-04  3.253495e-04
## ASV2410     -2.661096e-04 -2.781154e-04 -2.906347e-04 -3.036872e-04
## ASV2718      2.836523e-04  2.970104e-04  3.109860e-04  3.256061e-04
## ASV2738      3.208756e-04  3.347053e-04  3.490683e-04  3.639802e-04
## ASV2876      1.953923e-04  2.034810e-04  2.118553e-04  2.205214e-04
## ASV3177      1.953780e-04  2.034655e-04  2.118385e-04  2.205032e-04
## ASV4367      1.953637e-04  2.034500e-04  2.118217e-04  2.204850e-04
## ASV4635      6.696100e-05  7.068775e-05  7.463161e-05  7.880518e-05
## ASV4896      1.669783e-05  1.832485e-05  2.009661e-05  2.202480e-05
## ASV4907      1.432490e-04  1.503982e-04  1.579109e-04  1.658054e-04
## ASV5230     -1.953630e-04 -2.034496e-04 -2.118216e-04 -2.204854e-04
## ASV6509     -1.953487e-04 -2.034341e-04 -2.118048e-04 -2.204672e-04
## ASV7376     -1.953344e-04 -2.034186e-04 -2.117880e-04 -2.204490e-04
## ASV8163     -1.953201e-04 -2.034031e-04 -2.117712e-04 -2.204309e-04
## ASV8195     -1.953058e-04 -2.033876e-04 -2.117545e-04 -2.204127e-04
## ASV8923      1.192616e-04  1.250634e-04  1.311472e-04  1.375263e-04
## ASV9666     -1.732302e-04 -1.803021e-04 -1.876147e-04 -1.951727e-04
## ASV1482      1.761719e-04  1.842339e-04  1.926476e-04  2.014265e-04
## ASV2726      2.325623e-04  2.434682e-04  2.548738e-04  2.668004e-04
## ASV3281     -1.952902e-04 -2.033708e-04 -2.117365e-04 -2.203934e-04
## ASV4235     -1.952759e-04 -2.033554e-04 -2.117197e-04 -2.203753e-04
## ASV4808      2.881086e-04  3.006064e-04  3.135954e-04  3.270906e-04
## ASV4861     -2.898640e-04 -3.025462e-04 -3.157381e-04 -3.294566e-04
## ASV5276      2.842510e-04  2.965364e-04  3.092998e-04  3.225554e-04
## ASV5837      2.467389e-04  2.581888e-04  2.701572e-04  2.826665e-04
## ASV7098      2.523565e-04  2.640329e-04  2.762353e-04  2.889861e-04
## ASV8451     -1.952106e-04 -2.032843e-04 -2.116425e-04 -2.202913e-04
## ASV8694     -1.951963e-04 -2.032689e-04 -2.116257e-04 -2.202732e-04
## ASV0905     -1.039508e-04 -1.087834e-04 -1.138309e-04 -1.191017e-04
## ASV2900      2.395770e-04  2.497363e-04  2.602761e-04  2.712069e-04
## ASV3963     -1.897980e-04 -1.976218e-04 -2.057188e-04 -2.140950e-04
## ASV0041     -2.116061e-04 -2.214183e-04 -2.316710e-04 -2.423825e-04
## ASV1865      2.162073e-04  2.266773e-04  2.376545e-04  2.491629e-04
## ASV1140      1.728994e-04  1.808832e-04  1.892197e-04  1.979226e-04
## ASV1179      2.552202e-04  2.670409e-04  2.793923e-04  2.922967e-04
## ASV0279      3.593882e-04  3.755004e-04  3.922930e-04  4.097913e-04
## ASV0043     -3.318809e-05 -3.517191e-05 -3.728550e-05 -3.953790e-05
## ASV2097     -2.014669e-04 -2.102539e-04 -2.193924e-04 -2.288943e-04
## ASV0309     -1.001068e-04 -1.044131e-04 -1.088859e-04 -1.135302e-04
## ASV0607      4.393259e-04  4.597729e-04  4.811481e-04  5.034912e-04
## ASV0025     -4.601162e-04 -4.814301e-04 -5.037004e-04 -5.269669e-04
## ASV2284     -7.255774e-05 -7.521991e-05 -7.794432e-05 -8.072927e-05
## ASV0556      7.845888e-05  8.241868e-05  8.658330e-05  9.096337e-05
## ASV5040      1.638345e-04  1.704736e-04  1.773344e-04  1.844204e-04
## ASV2924     -1.751736e-04 -1.823419e-04 -1.897560e-04 -1.974206e-04
## ASV1331      5.573924e-04  5.825387e-04  6.087578e-04  6.360902e-04
## ASV0506     -2.539551e-04 -2.648676e-04 -2.761976e-04 -2.879568e-04
## ASV1514      4.208209e-04  4.400263e-04  4.600686e-04  4.809807e-04
## ASV2144      3.489447e-04  3.644842e-04  3.806677e-04  3.975177e-04
## ASV2265      4.669744e-04  4.881148e-04  5.101621e-04  5.331509e-04
## ASV5156      1.001079e-04  1.040748e-04  1.081644e-04  1.123777e-04
## ASV5534      8.078612e-05  8.380629e-05  8.690238e-05  9.007298e-05
## ASV5747     -1.660556e-05 -1.807761e-05 -1.967336e-05 -2.140229e-05
## ASV6657      2.092056e-04  2.182382e-04  2.276210e-04  2.373643e-04
## ASV0658     -2.382867e-04 -2.485618e-04 -2.592341e-04 -2.703151e-04
## ASV0716      5.763231e-05  6.001355e-05  6.247655e-05  6.502266e-05
## ASV1657      1.013382e-04  1.053280e-04  1.094388e-04  1.136713e-04
## ASV1885     -6.210507e-06 -7.138151e-06 -8.159772e-06 -9.283214e-06
## ASV2333      5.146420e-04  5.376362e-04  5.615918e-04  5.865435e-04
## ASV3375      1.894093e-04  1.974614e-04  2.058154e-04  2.144794e-04
## ASV4317      2.013671e-04  2.105877e-04  2.202159e-04  2.302685e-04
## ASV9599     -1.665929e-05 -1.813588e-05 -1.973652e-05 -2.147073e-05
## ASV0175     -6.888060e-04 -7.194087e-04 -7.512711e-04 -7.844364e-04
## ASV1032      2.041255e-04  2.128071e-04  2.218137e-04  2.311539e-04
## ASV1235      4.478159e-06  4.188623e-06  3.844878e-06  3.441509e-06
## ASV1262      6.077288e-04  6.349315e-04  6.632734e-04  6.927953e-04
## ASV1320      1.509522e-04  1.584300e-04  1.662857e-04  1.745383e-04
## ASV13797     2.256532e-04  2.356072e-04  2.459678e-04  2.567491e-04
## ASV1491      1.154652e-04  1.212454e-04  1.273192e-04  1.337011e-04
## ASV15014    -1.668101e-05 -1.815923e-05 -1.976160e-05 -2.149764e-05
## ASV1510      1.867088e-04  1.957042e-04  2.051308e-04  2.150085e-04
## ASV1551     -7.437099e-05 -7.759422e-05 -8.094278e-05 -8.442027e-05
## ASV1919     -1.011042e-05 -9.830192e-06 -9.475733e-06 -9.039270e-06
## ASV2114      1.105898e-04  1.151954e-04  1.199669e-04  1.249082e-04
## ASV21486    -1.667277e-05 -1.814989e-05 -1.975102e-05 -2.148566e-05
## ASV2448      3.085923e-04  3.220250e-04  3.359874e-04  3.504957e-04
## ASV2589      1.475119e-04  1.537805e-04  1.602839e-04  1.670285e-04
## ASV2608      2.488452e-04  2.599139e-04  2.714421e-04  2.834464e-04
## ASV2786      2.018104e-04  2.109906e-04  2.205726e-04  2.305730e-04
## ASV2827      2.577667e-04  2.691193e-04  2.809311e-04  2.932172e-04
## ASV2872      2.098814e-04  2.187623e-04  2.279704e-04  2.375136e-04
## ASV3125      2.509926e-04  2.618359e-04  2.731011e-04  2.848007e-04
## ASV3247      2.718394e-04  2.835733e-04  2.957613e-04  3.084163e-04
## ASV3451     -1.675141e-05 -1.823543e-05 -1.984402e-05 -2.158674e-05
## ASV3465     -3.491614e-05 -3.727010e-05 -3.979102e-05 -4.249059e-05
## ASV3809      1.583413e-04  1.650613e-04  1.720319e-04  1.792595e-04
## ASV4006      3.370847e-04  3.515335e-04  3.665306e-04  3.820907e-04
## ASV4046      2.422129e-04  2.526729e-04  2.635393e-04  2.748242e-04
## ASV4938     -1.832866e-05 -1.988668e-05 -2.157266e-05 -2.339629e-05
## ASV5435     -1.677474e-05 -1.826044e-05 -1.987081e-05 -2.161539e-05
## ASV5605      9.691827e-05  1.005995e-04  1.043784e-04  1.082536e-04
## ASV5635     -1.677784e-05 -1.826362e-05 -1.987406e-05 -2.161868e-05
## ASV5743      3.056751e-04  3.190904e-04  3.330464e-04  3.475610e-04
## ASV6627     -1.679125e-05 -1.827811e-05 -1.988971e-05 -2.163559e-05
## ASV6785     -1.678870e-05 -1.827522e-05 -1.988643e-05 -2.163186e-05
## ASV7368      3.370277e-04  3.524543e-04  3.685613e-04  3.853766e-04
## ASV9118      9.149556e-05  9.501391e-05  9.863056e-05  1.023450e-04
## ASV9135      7.140971e-05  7.394067e-05  7.652089e-05  7.914749e-05
## ASV9435      1.590411e-04  1.654785e-04  1.721262e-04  1.789868e-04
## ASV9671     -1.681291e-05 -1.830132e-05 -1.991455e-05 -2.166214e-05
## ASV0387     -3.386890e-04 -3.533531e-04 -3.685885e-04 -3.844121e-04
## ASV0454     -3.369655e-04 -3.517122e-04 -3.670472e-04 -3.829888e-04
## ASV0751     -2.209678e-04 -2.304707e-04 -2.403382e-04 -2.505807e-04
## ASV1081      8.958495e-05  9.362311e-05  9.783173e-05  1.022169e-04
## ASV1332      1.843787e-04  1.925826e-04  2.011254e-04  2.100190e-04
## ASV2659      2.935570e-04  3.069582e-04  3.209415e-04  3.355293e-04
## ASV2979      3.047752e-04  3.178429e-04  3.314076e-04  3.454830e-04
## ASV4184      1.231845e-04  1.279324e-04  1.328130e-04  1.378256e-04
## ASV6198      1.073440e-04  1.118952e-04  1.166167e-04  1.215131e-04
## ASV7454      1.991183e-04  2.077104e-04  2.166348e-04  2.259009e-04
## ASV8198      7.987304e-05  8.274239e-05  8.567159e-05  8.865783e-05
## ASV0855      4.461242e-04  4.664591e-04  4.876801e-04  5.098223e-04
## ASV10092     1.885494e-04  1.966947e-04  2.051576e-04  2.139477e-04
## ASV1532      2.431133e-04  2.544657e-04  2.663366e-04  2.787485e-04
## ASV2553      5.874711e-04  6.139827e-04  6.416252e-04  6.704410e-04
## ASV2741      2.361855e-04  2.472656e-04  2.588531e-04  2.709696e-04
## ASV4095      1.280704e-04  1.343874e-04  1.410180e-04  1.479770e-04
## ASV5295      1.732701e-04  1.804184e-04  1.878143e-04  1.954623e-04
## ASV5787     -1.686916e-05 -1.836204e-05 -1.998003e-05 -2.173269e-05
## ASV9455      2.291084e-04  2.390619e-04  2.494082e-04  2.601595e-04
## ASV10879     2.390803e-04  2.497700e-04  2.609095e-04  2.725155e-04
## ASV3997      1.667878e-04  1.747847e-04  1.831618e-04  1.919365e-04
## ASV6760      4.713360e-05  4.848848e-05  4.983595e-05  5.117052e-05
## ASV6990      1.729259e-04  1.803198e-04  1.879956e-04  1.959612e-04
## ASV9560      1.070299e-04  1.113833e-04  1.158832e-04  1.205320e-04
## ASV0220      9.463765e-05  9.883227e-05  1.031977e-04  1.077393e-04
## ASV2518      2.305896e-04  2.410821e-04  2.520301e-04  2.634514e-04
## ASV3615      3.629653e-04  3.791510e-04  3.960110e-04  4.135693e-04
## ASV0075      7.865112e-05  8.179735e-05  8.504122e-05  8.838313e-05
## ASV8070      4.381730e-05  4.510153e-05  4.638215e-05  4.765438e-05
## ASV1658      1.718255e-04  1.792527e-04  1.869690e-04  1.949833e-04
## ASV0773      2.775403e-04  2.895022e-04  3.019250e-04  3.148218e-04
## ASV0799      8.902972e-06  9.291373e-06  9.694972e-06  1.011420e-05
## ASV1839     -5.471997e-05 -5.678377e-05 -5.889772e-05 -6.106016e-05
## ASV0265      2.674823e-04  2.801859e-04  2.934862e-04  3.074101e-04
## ASV3741      1.078185e-04  1.126455e-04  1.176747e-04  1.229135e-04
## ASV0847      3.748688e-04  3.917060e-04  4.092531e-04  4.275357e-04
## ASV1026      4.003680e-04  4.182041e-04  4.367788e-04  4.561177e-04
## ASV1222     -1.267177e-04 -1.318474e-04 -1.371467e-04 -1.426182e-04
## ASV0729      5.469077e-05  5.709800e-05  5.960209e-05  6.220611e-05
## ASV0143     -3.042335e-04 -3.173106e-04 -3.308875e-04 -3.449781e-04
## ASV1328      7.800525e-05  8.127247e-05  8.465757e-05  8.816324e-05
## ASV9078     -7.902089e-05 -8.339847e-05 -8.803135e-05 -9.293461e-05
## ASV0027     -4.382509e-04 -4.584465e-04 -4.795386e-04 -5.015638e-04
## ASV0546     -1.914154e-04 -1.996488e-04 -2.081983e-04 -2.170730e-04
## ASV1136      4.881987e-04  5.100183e-04  5.327514e-04  5.564313e-04
## ASV3081      2.331209e-04  2.437132e-04  2.547663e-04  2.662988e-04
## ASV0531      1.034588e-04  1.083743e-04  1.135193e-04  1.189036e-04
## ASV2525      1.336030e-04  1.393843e-04  1.453911e-04  1.516300e-04
## ASV1083     -5.061478e-05 -5.252803e-05 -5.449273e-05 -5.650858e-05
## ASV0424      8.699641e-05  9.098569e-05  9.515181e-05  9.950214e-05
## ASV0644      1.161799e-05  1.263697e-05  1.374007e-05  1.493353e-05
## ASV6007     -1.700890e-05 -1.851639e-05 -2.015055e-05 -2.192109e-05
## ASV0564      1.202804e-04  1.261148e-04  1.322321e-04  1.386455e-04
## ASV1938      1.296884e-04  1.350813e-04  1.406660e-04  1.464468e-04
## ASV6516     -2.978332e-04 -3.112042e-04 -3.251387e-04 -3.396570e-04
## ASV0503     -3.490962e-04 -3.640512e-04 -3.795729e-04 -3.956768e-04
## ASV6913     -3.468678e-04 -3.617193e-04 -3.771358e-04 -3.931330e-04
## ASV0164     -2.769508e-04 -2.899555e-04 -3.035611e-04 -3.177943e-04
## ASV1576      3.310182e-04  3.458890e-04  3.613901e-04  3.775452e-04
## ASV1725      1.606185e-04  1.683849e-04  1.765258e-04  1.850588e-04
## ASV4501      1.400248e-04  1.457865e-04  1.517465e-04  1.579085e-04
## ASV10678    -2.905474e-04 -3.034597e-04 -3.169039e-04 -3.308985e-04
## ASV0944      2.421448e-04  2.535097e-04  2.653981e-04  2.778333e-04
## ASV2292      3.771339e-04  3.938847e-04  4.113262e-04  4.294822e-04
## ASV1090      2.471544e-04  2.583626e-04  2.700548e-04  2.822499e-04
## ASV9117     -1.202572e-04 -1.251499e-04 -1.302072e-04 -1.354317e-04
## ASV0285     -1.460038e-04 -1.532398e-04 -1.608400e-04 -1.688226e-04
## ASV0463     -2.409857e-04 -2.514684e-04 -2.623631e-04 -2.736823e-04
## ASV3199      2.077784e-04  2.166544e-04  2.258665e-04  2.354239e-04
## ASV0150     -8.525382e-05 -8.945882e-05 -9.387385e-05 -9.850931e-05
## ASV6583     -1.233459e-04 -1.285431e-04 -1.339331e-04 -1.395210e-04
## ASV0392      1.977553e-04  2.067975e-04  2.162364e-04  2.260880e-04
## ASV14007    -2.390327e-04 -2.496789e-04 -2.607661e-04 -2.723096e-04
## ASV0177     -1.317441e-04 -1.373685e-04 -1.432052e-04 -1.492599e-04
## ASV6448     -1.026734e-04 -1.080795e-04 -1.137813e-04 -1.197949e-04
## ASV5399     -4.267590e-05 -4.534620e-05 -4.819319e-05 -5.122852e-05
## ASV0277     -4.931047e-05 -5.160912e-05 -5.401209e-05 -5.652380e-05
## ASV2599      8.139679e-05  8.416755e-05  8.698011e-05  8.982990e-05
## ASV13465    -6.514746e-05 -6.720748e-05 -6.928049e-05 -7.136090e-05
## ASV2412      1.238009e-04  1.294505e-04  1.353463e-04  1.414979e-04
## ASV0423      2.447836e-04  2.565667e-04  2.689205e-04  2.818728e-04
## ASV5187      1.508292e-04  1.569861e-04  1.633520e-04  1.699306e-04
## ASV0701     -5.695093e-04 -5.953242e-04 -6.222479e-04 -6.503224e-04
## ASV4248      1.364492e-04  1.430303e-04  1.499267e-04  1.571529e-04
## ASV0519      2.397094e-04  2.509046e-04  2.626091e-04  2.748446e-04
## ASV0764      4.139332e-05  4.360714e-05  4.594549e-05  4.841559e-05
## ASV5385     -2.997081e-04 -3.134019e-04 -3.276940e-04 -3.426081e-04
## ASV3021     -1.679823e-04 -1.746781e-04 -1.815853e-04 -1.887062e-04
## ASV4119     -9.353163e-05 -9.715603e-05 -1.008847e-04 -1.047176e-04
## ASV2534      4.874353e-05  5.085138e-05  5.304241e-05  5.531936e-05
## ASV1061      2.313042e-04  2.427897e-04  2.548603e-04  2.675465e-04
## ASV0670      3.195229e-04  3.341284e-04  3.493729e-04  3.652814e-04
## ASV1384      1.392781e-04  1.461630e-04  1.533930e-04  1.609851e-04
## ASV1981      2.978021e-04  3.115629e-04  3.259374e-04  3.409506e-04
## ASV9632     -9.739320e-05 -1.010346e-04 -1.047688e-04 -1.085944e-04
## ASV4564      7.344094e-05  7.687165e-05  8.045854e-05  8.420828e-05
## ASV5289     -6.634349e-05 -6.934378e-05 -7.247228e-05 -7.573378e-05
## ASV0516      6.055030e-04  6.330907e-04  6.618764e-04  6.919067e-04
## ASV1463     -2.176625e-04 -2.271892e-04 -2.370946e-04 -2.473905e-04
## ASV0969      1.010814e-04  1.054198e-04  1.099224e-04  1.145935e-04
## ASV1113     -2.820740e-04 -2.949187e-04 -3.083218e-04 -3.223054e-04
## ASV1234     -1.115916e-05 -1.232602e-05 -1.360257e-05 -1.499821e-05
## ASV3814      4.150791e-05  4.257397e-05  4.361772e-05  4.463295e-05
## ASV1000      2.878089e-04  3.005578e-04  3.138280e-04  3.276372e-04
## ASV0079     -2.616476e-05 -2.777180e-05 -2.948594e-05 -3.131465e-05
## ASV0145      9.733218e-05  1.013829e-04  1.055779e-04  1.099201e-04
## ASV0457     -3.622429e-04 -3.781451e-04 -3.946859e-04 -4.118856e-04
## ASV1485      1.185792e-04  1.241549e-04  1.299895e-04  1.360945e-04
## ASV0535     -7.980585e-05 -8.328450e-05 -8.690330e-05 -9.066718e-05
## ASV0259     -2.373989e-04 -2.480161e-04 -2.590750e-04 -2.705908e-04
## ASV0570      1.811377e-05  1.931595e-05  2.060289e-05  2.198059e-05
## ASV0906      3.085327e-04  3.222113e-04  3.364509e-04  3.512705e-04
## ASV1748     -1.832676e-04 -1.923121e-04 -2.018083e-04 -2.117785e-04
## ASV5520     -1.089768e-04 -1.147261e-04 -1.207919e-04 -1.271919e-04
## ASV2288     -3.532070e-04 -3.684983e-04 -3.843842e-04 -4.008820e-04
## ASV1887     -6.798525e-05 -7.170385e-05 -7.563502e-05 -7.979092e-05
## ASV0374     -1.120071e-04 -1.167780e-04 -1.217273e-04 -1.268598e-04
## ASV0823      3.481289e-04  3.633543e-04  3.791874e-04  3.956475e-04
## ASV0717      1.756203e-04  1.837071e-04  1.921533e-04  2.009735e-04
## ASV0431      1.207225e-04  1.259676e-04  1.314179e-04  1.370793e-04
## ASV1030      5.087301e-04  5.325576e-04  5.574775e-04  5.835375e-04
## ASV1082     -7.422587e-05 -7.760865e-05 -8.113822e-05 -8.482026e-05
## ASV2684      4.771942e-05  5.045878e-05  5.336324e-05  5.644270e-05
## ASV0051      4.517865e-04  4.726910e-04  4.945344e-04  5.173564e-04
## ASV0513      1.912284e-05  2.009569e-05  2.112007e-05  2.219883e-05
## ASV0581      5.726995e-04  5.988690e-04  6.261821e-04  6.546842e-04
## ASV7282      1.011060e-04  1.063042e-04  1.117822e-04  1.175560e-04
## ASV3009     -3.138905e-04 -3.281596e-04 -3.430457e-04 -3.585726e-04
## ASV2106     -1.587969e-04 -1.655471e-04 -1.725499e-04 -1.798118e-04
## ASV1012      1.011051e-04  1.060658e-04  1.112725e-04  1.167373e-04
## ASV0921     -6.554603e-06 -6.722224e-06 -6.885323e-06 -7.042676e-06
## ASV0010     -4.482562e-04 -4.690582e-04 -4.907972e-04 -5.135126e-04
## ASV1178      9.476655e-06  1.007879e-05  1.072048e-05  1.140418e-05
## ASV2848     -2.403169e-04 -2.509159e-04 -2.619472e-04 -2.734258e-04
## ASV0586      6.497186e-04  6.795117e-04  7.106167e-04  7.430864e-04
## ASV4225      1.965897e-05  2.089842e-05  2.221672e-05  2.361839e-05
## ASV2156     -2.707879e-04 -2.831727e-04 -2.961006e-04 -3.095932e-04
## ASV9778     -1.705246e-04 -1.781541e-04 -1.861022e-04 -1.943805e-04
## ASV0493     -3.774351e-04 -3.942035e-04 -4.116644e-04 -4.298419e-04
## ASV3770      6.904283e-05  7.190357e-05  7.486691e-05  7.793544e-05
## ASV0470      4.611258e-04  4.820933e-04  5.039692e-04  5.267888e-04
## ASV0262     -1.930338e-04 -2.025375e-04 -2.125157e-04 -2.229923e-04
## ASV0998      2.829650e-04  2.959807e-04  3.095737e-04  3.237679e-04
## ASV7708     -7.707965e-05 -8.045711e-05 -8.396930e-05 -8.762044e-05
## ASV0453     -9.686506e-06 -1.009342e-05 -1.051671e-05 -1.095714e-05
## ASV0044      5.811575e-04  6.076920e-04  6.353860e-04  6.642856e-04
## ASV5490      9.091268e-05  9.485818e-05  9.895666e-05  1.032123e-04
## ASV2638      2.501649e-05  2.630180e-05  2.765319e-05  2.907374e-05
## ASV0829     -5.151590e-05 -5.347561e-05 -5.548898e-05 -5.755576e-05
## ASV0601      1.072808e-04  1.124350e-04  1.178379e-04  1.235013e-04
## ASV0234      2.521626e-04  2.635518e-04  2.754271e-04  2.878065e-04
## ASV0133      3.335843e-04  3.488727e-04  3.648344e-04  3.814968e-04
## ASV0323      3.542031e-04  3.707988e-04  3.881591e-04  4.063181e-04
## ASV0854     -2.664761e-05 -2.765896e-05 -2.869560e-05 -2.975680e-05
## ASV0110      4.479275e-04  4.686815e-04  4.903695e-04  5.130308e-04
## ASV0816      2.420227e-05  2.524115e-05  2.632033e-05  2.744110e-05
## ASV1031     -6.999291e-05 -7.302749e-05 -7.618306e-05 -7.946382e-05
## ASV0144     -1.823388e-04 -1.905642e-04 -1.991400e-04 -2.080792e-04
## ASV0020     -8.409098e-05 -8.847360e-05 -9.309841e-05 -9.797974e-05
## ASV0962     -1.492790e-04 -1.560484e-04 -1.631087e-04 -1.704711e-04
## ASV0794      2.953915e-04  3.095360e-04  3.243547e-04  3.398787e-04
## ASV7117     -1.522664e-04 -1.592611e-04 -1.665662e-04 -1.741946e-04
## ASV1008     -1.088523e-04 -1.140570e-04 -1.195103e-04 -1.252243e-04
## ASV0096      4.824937e-04  5.048663e-04  5.282472e-04  5.526792e-04
## ASV0128     -2.893292e-04 -3.031841e-04 -3.177038e-04 -3.329202e-04
## ASV5232      2.187935e-04  2.289761e-04  2.396190e-04  2.507416e-04
## ASV0031      1.355034e-05  1.388488e-05  1.420786e-05  1.451644e-05
## ASV1744     -3.332269e-05 -3.494423e-05 -3.664839e-05 -3.843984e-05
## ASV0289      2.685413e-04  2.809106e-04  2.938316e-04  3.073275e-04
## ASV7413     -6.101324e-05 -6.448216e-05 -6.815958e-05 -7.205816e-05
## ASV0822     -3.228597e-04 -3.371072e-04 -3.519338e-04 -3.673588e-04
## ASV8111     -2.722440e-04 -2.836871e-04 -2.955473e-04 -3.078347e-04
## ASV0687      2.018853e-04  2.113883e-04  2.213301e-04  2.317300e-04
## ASV0112      6.263673e-05  6.470312e-05  6.678617e-05  6.887972e-05
## ASV0987      1.627309e-04  1.704054e-04  1.784372e-04  1.868425e-04
## ASV5332     -8.878591e-05 -9.239165e-05 -9.612027e-05 -9.997432e-05
## ASV1129     -2.124931e-04 -2.223107e-04 -2.325692e-04 -2.432874e-04
## ASV1274     -6.971031e-05 -7.293594e-05 -7.630615e-05 -7.982698e-05
## ASV0119      3.930724e-04  4.112707e-04  4.302867e-04  4.501546e-04
## ASV0890      9.964891e-05  1.044107e-04  1.093993e-04  1.146252e-04
## ASV0848      5.634973e-04  5.893329e-04  6.163059e-04  6.444619e-04
## ASV5944     -2.933686e-04 -3.060254e-04 -3.191711e-04 -3.328197e-04
## ASV19741    -2.949629e-04 -3.083927e-04 -3.224065e-04 -3.370272e-04
## ASV0504     -3.376823e-04 -3.526656e-04 -3.682659e-04 -3.845049e-04
## ASV2146     -2.216333e-04 -2.315520e-04 -2.418907e-04 -2.526656e-04
## ASV0089     -1.855213e-04 -1.943242e-04 -2.035406e-04 -2.131893e-04
## ASV2301     -1.962317e-04 -2.053331e-04 -2.148447e-04 -2.247840e-04
## ASV2982      5.905712e-05  6.198665e-05  6.505959e-05  6.828227e-05
## ASV0891     -2.481851e-04 -2.595349e-04 -2.713823e-04 -2.837471e-04
## ASV0093      4.029629e-04  4.213758e-04  4.405946e-04  4.606514e-04
## ASV0042      1.905054e-04  1.989971e-04  2.078411e-04  2.170500e-04
## ASV0980      2.669341e-04  2.788446e-04  2.912502e-04  3.041684e-04
## ASV0069     -6.779994e-05 -7.115731e-05 -7.468555e-05 -7.839365e-05
## ASV1364     -4.781373e-05 -5.004529e-05 -5.237911e-05 -5.481974e-05
## ASV0524     -7.816899e-05 -8.199595e-05 -8.601375e-05 -9.023212e-05
## ASV0435      5.330811e-04  5.576270e-04  5.832637e-04  6.100362e-04
## ASV0517     -2.163915e-04 -2.262727e-04 -2.365850e-04 -2.473456e-04
## ASV3167     -9.355059e-05 -9.798096e-05 -1.026176e-04 -1.074696e-04
## ASV4280     -3.942941e-05 -4.143225e-05 -4.354216e-05 -4.576527e-05
## ASV1158      1.304129e-04  1.367608e-04  1.434172e-04  1.503965e-04
## ASV2214      1.009516e-04  1.056069e-04  1.104737e-04  1.155615e-04
## ASV0544     -1.197701e-04 -1.253145e-04 -1.311078e-04 -1.371603e-04
## ASV5326     -2.168522e-05 -2.263761e-05 -2.362849e-05 -2.465914e-05
## ASV3765     -3.104390e-04 -3.242533e-04 -3.386376e-04 -3.536116e-04
## ASV4646     -8.117708e-06 -9.026301e-06 -1.001967e-05 -1.110471e-05
## ASV0090      3.091015e-05  3.205492e-05  3.322576e-05  3.442159e-05
## ASV3680      2.925803e-04  3.052798e-04  3.184762e-04  3.321842e-04
## ASV0111      4.846846e-05  5.044778e-05  5.249256e-05  5.460355e-05
## ASV0768      1.824395e-04  1.908729e-04  1.996846e-04  2.088906e-04
## ASV4862     -1.061223e-05 -1.101987e-05 -1.143852e-05 -1.186805e-05
## ASV1742     -2.402190e-04 -2.507108e-04 -2.616213e-04 -2.729641e-04
## ASV3701     -4.232646e-05 -4.432785e-05 -4.642381e-05 -4.861885e-05
## ASV2386     -1.449230e-04 -1.514734e-04 -1.583031e-04 -1.654225e-04
## ASV0375     -3.383948e-04 -3.533516e-04 -3.689193e-04 -3.851186e-04
## ASV2796      9.030145e-05  9.424821e-05  9.835276e-05  1.026202e-04
## ASV1369      2.338628e-04  2.442348e-04  2.550352e-04  2.662791e-04
## ASV10272    -2.119592e-04 -2.214845e-04 -2.314116e-04 -2.417550e-04
## ASV10354    -2.119423e-04 -2.214660e-04 -2.313914e-04 -2.417330e-04
## ASV1067     -1.817565e-05 -1.908772e-05 -2.004718e-05 -2.105659e-05
## ASV1900      4.445308e-04  4.650215e-04  4.864245e-04  5.087774e-04
## ASV4079     -7.630415e-05 -7.991807e-05 -8.370075e-05 -8.765970e-05
## ASV4149      2.979896e-04  3.109554e-04  3.244310e-04  3.384316e-04
## ASV5140     -2.119252e-04 -2.214474e-04 -2.313711e-04 -2.417107e-04
## ASV10782    -9.525800e-06 -9.809395e-06 -1.009167e-05 -1.037137e-05
## ASV4273     -4.853930e-05 -5.054741e-05 -5.262404e-05 -5.477015e-05
## ASV8121      2.047454e-04  2.141858e-04  2.240477e-04  2.343489e-04
## ASV8438     -2.119103e-04 -2.214312e-04 -2.313534e-04 -2.416915e-04
## ASV9390     -2.118934e-04 -2.214127e-04 -2.313332e-04 -2.416695e-04
## ASV1340      2.940951e-04  3.077229e-04  3.219636e-04  3.368427e-04
## ASV2650     -3.145371e-04 -3.284861e-04 -3.430069e-04 -3.581185e-04
## ASV4674      1.613173e-04  1.686836e-04  1.763715e-04  1.843936e-04
## ASV10492    -1.394615e-05 -1.463915e-05 -1.536767e-05 -1.613362e-05
## ASV11430    -2.118682e-04 -2.213852e-04 -2.313033e-04 -2.416369e-04
## ASV12135    -2.118512e-04 -2.213667e-04 -2.312831e-04 -2.416149e-04
## ASV14970    -2.118343e-04 -2.213482e-04 -2.312629e-04 -2.415928e-04
## ASV1954      2.419177e-04  2.529639e-04  2.644916e-04  2.765199e-04
## ASV2613      3.779202e-04  3.950784e-04  4.129771e-04  4.316449e-04
## ASV2757      1.491455e-04  1.556288e-04  1.623665e-04  1.693663e-04
## ASV2909     -2.215320e-04 -2.316978e-04 -2.423116e-04 -2.533916e-04
## ASV2954     -4.248567e-05 -4.426914e-05 -4.611594e-05 -4.802723e-05
## ASV2969      2.091422e-04  2.189185e-04  2.291423e-04  2.398331e-04
## ASV3410      4.514280e-05  4.744360e-05  4.986703e-05  5.241998e-05
## ASV3575      1.111376e-04  1.162435e-04  1.215764e-04  1.271457e-04
## ASV4275      2.403563e-04  2.508732e-04  2.618084e-04  2.731747e-04
## ASV4652      4.257514e-05  4.474825e-05  4.703659e-05  4.944646e-05
## ASV4761      2.401430e-04  2.506652e-04  2.616064e-04  2.729796e-04
## ASV6003      1.867243e-04  1.956421e-04  2.049859e-04  2.147758e-04
## ASV6110     -2.118710e-04 -2.213884e-04 -2.313069e-04 -2.416409e-04
## ASV7427      1.387102e-04  1.450478e-04  1.516627e-04  1.585659e-04
## ASV8092     -2.118601e-04 -2.213765e-04 -2.312939e-04 -2.416269e-04
## ASV8169     -2.118432e-04 -2.213580e-04 -2.312738e-04 -2.416048e-04
## ASV9693      9.277024e-05  9.703519e-05  1.014889e-04  1.061391e-04
## ASV10913     1.024880e-04  1.073775e-04  1.124995e-04  1.178649e-04
## ASV1979     -3.450302e-05 -3.599977e-05 -3.755497e-05 -3.917036e-05
## ASV3772      2.627531e-04  2.745363e-04  2.868157e-04  2.996092e-04
## ASV0113      4.937229e-05  5.139594e-05  5.348640e-05  5.564430e-05
## ASV1800     -2.266725e-05 -2.376550e-05 -2.491624e-05 -2.612181e-05
## ASV2335     -2.659000e-04 -2.770873e-04 -2.886832e-04 -3.006976e-04
## ASV0692      9.148860e-05  9.576472e-05  1.002361e-04  1.049111e-04
## ASV1120      1.152667e-04  1.205145e-04  1.259900e-04  1.317018e-04
## ASV1434     -6.114278e-04 -6.392887e-04 -6.683618e-04 -6.986945e-04
## ASV0076     -7.122478e-05 -7.473565e-05 -7.842385e-05 -8.229859e-05
## ASV0361      4.634303e-04  4.848714e-04  5.072743e-04  5.306794e-04
## ASV2231     -1.563942e-04 -1.641756e-04 -1.723554e-04 -1.809545e-04
## ASV2018     -1.310835e-05 -1.404925e-05 -1.506351e-05 -1.615709e-05
## ASV1529      3.847518e-04  4.026792e-04  4.214227e-04  4.410177e-04
## ASV0841     -1.919253e-05 -1.993278e-05 -2.069298e-05 -2.147281e-05
## ASV2556     -2.308958e-04 -2.413123e-04 -2.521718e-04 -2.634909e-04
## ASV2777      2.912301e-04  3.038581e-04  3.169788e-04  3.306066e-04
## ASV0355      2.402323e-04  2.513970e-04  2.630679e-04  2.752669e-04
## ASV5169     -3.281573e-04 -3.430090e-04 -3.584968e-04 -3.746447e-04
## ASV3091      1.613347e-04  1.689955e-04  1.770179e-04  1.854188e-04
## ASV2435      2.315254e-04  2.419143e-04  2.527393e-04  2.640161e-04
## ASV6822     -1.495108e-04 -1.562301e-04 -1.632327e-04 -1.705289e-04
## ASV12605    -3.582967e-04 -3.745438e-04 -3.914899e-04 -4.091617e-04
## ASV0286     -2.396834e-04 -2.505745e-04 -2.619386e-04 -2.737946e-04
## ASV0074     -1.528271e-05 -1.654049e-05 -1.790427e-05 -1.938285e-05
## ASV2485     -9.503865e-06 -9.717723e-06 -9.922535e-06 -1.011652e-05
## ASV1233     -4.583325e-04 -4.793717e-04 -5.013413e-04 -5.242794e-04
## ASV0356     -2.186400e-04 -2.284412e-04 -2.386557e-04 -2.492985e-04
## ASV2918     -2.639547e-04 -2.752582e-04 -2.869907e-04 -2.991638e-04
## ASV1427     -4.731059e-07 -6.328769e-07 -8.124440e-07 -1.013773e-06
## ASV1409      2.689510e-04  2.816490e-04  2.949409e-04  3.088538e-04
## ASV0770      8.187379e-05  8.518200e-05  8.859356e-05  9.210859e-05
## ASV1403     -3.216491e-04 -3.362546e-04 -3.514907e-04 -3.673817e-04
## ASV0314     -1.746592e-04 -1.826569e-04 -1.910051e-04 -1.997180e-04
## ASV0187      3.238396e-06  3.099425e-06  2.930160e-06  2.727493e-06
## ASV0313     -2.331715e-04 -2.435384e-04 -2.543329e-04 -2.655698e-04
## ASV1087      4.077835e-04  4.265707e-04  4.461942e-04  4.666887e-04
## ASV1970      2.137785e-05  2.220839e-05  2.306187e-05  2.393801e-05
## ASV0754      3.281411e-04  3.432584e-04  3.590489e-04  3.755405e-04
## ASV3775     -2.238817e-04 -2.343356e-04 -2.452674e-04 -2.566980e-04
## ASV0132      9.135582e-05  9.536539e-05  9.953455e-05  1.038681e-04
## ASV2329     -6.481532e-05 -6.836504e-05 -7.211964e-05 -7.609117e-05
## ASV0561      2.796433e-04  2.921096e-04  3.050927e-04  3.186103e-04
## ASV0130     -3.429945e-04 -3.587266e-04 -3.751513e-04 -3.922965e-04
## ASV0226      3.890628e-04  4.068595e-04  4.254360e-04  4.448232e-04
## ASV12648    -2.758481e-04 -2.882813e-04 -3.012460e-04 -3.147626e-04
## ASV0204      3.878284e-04  4.055616e-04  4.240711e-04  4.433876e-04
## ASV0767      6.401753e-05  6.651039e-05  6.907213e-05  7.170177e-05
## ASV0335     -2.125420e-04 -2.223436e-04 -2.325815e-04 -2.432736e-04
## ASV5901     -6.300577e-05 -6.560606e-05 -6.829675e-05 -7.107960e-05
## ASV0596     -8.124228e-05 -8.453961e-05 -8.794355e-05 -9.145497e-05
## ASV9271      8.013834e-05  8.430939e-05  8.870579e-05  9.333983e-05
## ASV0904      3.420538e-04  3.578321e-04  3.743143e-04  3.915295e-04
## ASV15270    -8.959143e-05 -9.398043e-05 -9.858321e-05 -1.034096e-04
## ASV0990     -9.913349e-05 -1.038735e-04 -1.088402e-04 -1.140444e-04
## ASV0155     -2.056383e-04 -2.149533e-04 -2.246684e-04 -2.347988e-04
## ASV0086     -8.371201e-07 -7.854451e-07 -7.233996e-07 -6.498595e-07
## ASV2581     -1.219031e-05 -1.246344e-05 -1.272153e-05 -1.296142e-05
## ASV1579     -2.435453e-04 -2.550837e-04 -2.671639e-04 -2.798108e-04
## ASV7730     -1.047150e-05 -1.139126e-05 -1.238714e-05 -1.346481e-05
## ASV0897      9.959441e-05  1.041983e-04  1.090083e-04  1.140330e-04
## ASV1975      4.675894e-04  4.889023e-04  5.111434e-04  5.343493e-04
## ASV0759     -1.108329e-05 -1.149587e-05 -1.191828e-05 -1.235023e-05
## ASV3082     -2.839776e-04 -2.970268e-04 -3.106538e-04 -3.248820e-04
## ASV3195     -4.960637e-04 -5.191826e-04 -5.433552e-04 -5.686276e-04
## ASV0427      2.604027e-04  2.725776e-04  2.853106e-04  2.986260e-04
## ASV2674      5.362090e-05  5.593577e-05  5.833792e-05  6.082935e-05
## ASV1500      8.065648e-05  8.432860e-05  8.816075e-05  9.215929e-05
## ASV0102     -2.981046e-04 -3.121283e-04 -3.268028e-04 -3.421573e-04
## ASV1217     -7.471467e-05 -7.793297e-05 -8.127348e-05 -8.473930e-05
## ASV4998     -3.122944e-05 -3.265445e-05 -3.414131e-05 -3.569240e-05
## ASV2890      4.240303e-04  4.431021e-04  4.629812e-04  4.836974e-04
## ASV0672     -1.845288e-04 -1.930420e-04 -2.019355e-04 -2.112251e-04
## ASV6960     -1.675698e-04 -1.756885e-04 -1.841997e-04 -1.931215e-04
## ASV0821      2.751171e-04  2.873366e-04  3.000603e-04  3.133058e-04
## ASV1995     -2.634285e-04 -2.755696e-04 -2.882511e-04 -3.014952e-04
## ASV0211     -1.488412e-04 -1.560818e-04 -1.636777e-04 -1.716463e-04
## ASV0364      1.538906e-04  1.610243e-04  1.684798e-04  1.762709e-04
## ASV3616      3.287262e-04  3.430085e-04  3.578509e-04  3.732700e-04
## ASV1996      3.724293e-04  3.893823e-04  4.070732e-04  4.255313e-04
## ASV1881     -6.060156e-05 -6.343618e-05 -6.640071e-05 -6.950083e-05
## ASV1089      3.630744e-04  3.796011e-04  3.968445e-04  4.148322e-04
## ASV1450     -7.441057e-05 -7.769884e-05 -8.112077e-05 -8.468076e-05
## ASV4643     -2.073274e-04 -2.167378e-04 -2.265536e-04 -2.367903e-04
## ASV3458      1.023879e-04  1.071690e-04  1.121636e-04  1.173801e-04
## ASV2543     -9.126839e-05 -9.563457e-05 -1.002097e-04 -1.050037e-04
## ASV3306     -1.034537e-04 -1.082799e-04 -1.133212e-04 -1.185861e-04
## ASV0218     -2.024545e-04 -2.117977e-04 -2.215592e-04 -2.317564e-04
## ASV3727      1.360409e-04  1.426181e-04  1.495159e-04  1.567501e-04
## ASV4394     -1.466610e-04 -1.536293e-04 -1.609261e-04 -1.685663e-04
## ASV2636      1.219656e-05  1.334955e-05  1.460764e-05  1.597996e-05
## ASV5116      3.648535e-05  3.809414e-05  3.976803e-05  4.150916e-05
## ASV1394     -3.603366e-04 -3.769316e-04 -3.942648e-04 -4.123669e-04
## ASV0656     -3.530867e-04 -3.690585e-04 -3.857142e-04 -4.030796e-04
## ASV0475      5.373466e-04  5.622144e-04  5.881989e-04  6.153470e-04
## ASV1042      1.341185e-04  1.402841e-04  1.467221e-04  1.534436e-04
## ASV1199     -2.774215e-04 -2.903599e-04 -3.038890e-04 -3.180347e-04
## ASV12962    -1.843943e-05 -1.920321e-05 -1.999337e-05 -2.081035e-05
## ASV0853      2.511804e-04  2.626316e-04  2.745786e-04  2.870402e-04
## ASV5069     -5.813901e-05 -6.155883e-05 -6.519320e-05 -6.905589e-05
## ASV7825     -1.567972e-04 -1.640228e-04 -1.715696e-04 -1.794507e-04
## ASV0339      1.756470e-04  1.837385e-04  1.921904e-04  2.010177e-04
## ASV2965      1.530131e-04  1.600861e-04  1.674756e-04  1.751947e-04
## ASV2347     -2.028631e-04 -2.119099e-04 -2.213331e-04 -2.311460e-04
## ASV0541      8.942692e-05  9.384075e-05  9.847713e-05  1.033475e-04
## ASV0369      2.380198e-04  2.488426e-04  2.601339e-04  2.719119e-04
## ASV0171      1.205415e-04  1.261011e-04  1.319099e-04  1.379783e-04
## ASV2235      2.885262e-04  3.010753e-04  3.141185e-04  3.276710e-04
## ASV5809     -2.712410e-04 -2.834958e-04 -2.962736e-04 -3.095940e-04
## ASV1267      3.417797e-04  3.573227e-04  3.735377e-04  3.904506e-04
## ASV0207     -3.679421e-04 -3.846024e-04 -4.019768e-04 -4.200921e-04
## ASV3126     -4.356532e-04 -4.558927e-04 -4.770478e-04 -4.991577e-04
## ASV0183     -4.799220e-04 -5.018772e-04 -5.247955e-04 -5.487153e-04
## ASV1792      1.642200e-04  1.715277e-04  1.791367e-04  1.870575e-04
## ASV2001     -4.236664e-04 -4.434146e-04 -4.640634e-04 -4.856523e-04
## ASV5732     -4.162793e-04 -4.353217e-04 -4.551983e-04 -4.759425e-04
## ASV2857     -2.638658e-04 -2.760957e-04 -2.888770e-04 -3.022333e-04
## ASV1052     -1.920801e-04 -2.007350e-04 -2.097592e-04 -2.191670e-04
## ASV3226     -1.223972e-04 -1.280224e-04 -1.338967e-04 -1.400301e-04
## ASV3766     -4.526420e-05 -4.737247e-05 -4.957685e-05 -5.188154e-05
## ASV0982     -1.325310e-04 -1.388877e-04 -1.455501e-04 -1.525329e-04
## ASV0489     -3.215186e-06 -3.743575e-06 -4.329428e-06 -4.978046e-06
## ASV3990     -4.529840e-04 -4.739765e-04 -4.959146e-04 -5.188383e-04
## ASV0433     -2.685638e-04 -2.806098e-04 -2.931610e-04 -3.062350e-04
## ASV0684     -1.161707e-04 -1.217552e-04 -1.276107e-04 -1.337505e-04
## ASV0063     -3.179819e-04 -3.325364e-04 -3.477286e-04 -3.635837e-04
## ASV1399      5.392888e-05  5.594452e-05  5.800665e-05  6.011324e-05
## ASV3093     -5.398962e-04 -5.650752e-04 -5.914036e-04 -6.189317e-04
## ASV1771      6.626000e-05  6.947301e-05  7.284340e-05  7.637894e-05
## ASV7910     -2.716424e-04 -2.834171e-04 -2.956511e-04 -3.083579e-04
## ASV3718     -3.612344e-04 -3.778501e-04 -3.952026e-04 -4.133222e-04
## ASV0039     -2.846045e-04 -2.980533e-04 -3.121296e-04 -3.268616e-04
## ASV6469     -5.902116e-04 -6.171542e-04 -6.452719e-04 -6.746109e-04
## ASV8186     -3.998171e-04 -4.181961e-04 -4.373893e-04 -4.574300e-04
## ASV1091     -4.081142e-05 -4.279980e-05 -4.488646e-05 -4.707630e-05
## ASV16930    -4.888708e-04 -5.114153e-04 -5.349649e-04 -5.595612e-04
## ASV7234     -3.660635e-04 -3.829167e-04 -4.005187e-04 -4.189004e-04
## ASV1560     -4.405046e-05 -4.614341e-05 -4.833513e-05 -5.063018e-05
## ASV2968      7.412694e-05  7.773057e-05  8.151207e-05  8.548041e-05
## ASV3824     -3.763088e-04 -3.934817e-04 -4.114041e-04 -4.301058e-04
## ASV0442     -2.347728e-04 -2.456821e-04 -2.570851e-04 -2.690031e-04
## ASV0677     -1.783220e-04 -1.860448e-04 -1.940676e-04 -2.023990e-04
## ASV4796     -2.503128e-04 -2.615908e-04 -2.733495e-04 -2.856071e-04
## ASV2206     -3.996191e-04 -4.180871e-04 -4.373824e-04 -4.575393e-04
## ASV2884      7.962277e-05  8.330764e-05  8.715776e-05  9.118003e-05
## ASV0482     -1.450710e-04 -1.518222e-04 -1.588802e-04 -1.662583e-04
## ASV1273      3.320555e-04  3.475114e-04  3.636663e-04  3.805498e-04
## ASV1910      4.389843e-05  4.565427e-05  4.746446e-05  4.932919e-05
## ASV0105      2.512557e-04  2.624045e-04  2.740107e-04  2.860898e-04
## ASV0149      2.665521e-04  2.788099e-04  2.916109e-04  3.049771e-04
## ASV5007     -4.152913e-04 -4.345107e-04 -4.545930e-04 -4.755746e-04
## ASV0757      3.586484e-04  3.753049e-04  3.927152e-04  4.109116e-04
## ASV11952    -2.972381e-04 -3.106513e-04 -3.246351e-04 -3.392107e-04
## ASV4102      2.367313e-04  2.476968e-04  2.591551e-04  2.711269e-04
## ASV1034      2.986139e-04  3.122011e-04  3.263784e-04  3.411687e-04
## ASV0753      2.217601e-04  2.319282e-04  2.425446e-04  2.536276e-04
## ASV2323      1.344966e-04  1.407901e-04  1.473723e-04  1.542561e-04
## ASV0881     -1.048396e-04 -1.095086e-04 -1.143699e-04 -1.194300e-04
## ASV3730     -2.783955e-04 -2.911344e-04 -3.044318e-04 -3.183102e-04
## ASV2685     -1.066670e-04 -1.113098e-04 -1.161339e-04 -1.211444e-04
## ASV3826     -5.271110e-05 -5.514531e-05 -5.768904e-05 -6.034701e-05
## ASV0689      2.444436e-05  2.579460e-05  2.722539e-05  2.874188e-05
## ASV4315     -3.646890e-04 -3.815853e-04 -3.992425e-04 -4.176930e-04
## ASV1239      1.759447e-04  1.834716e-04  1.912835e-04  1.993882e-04
## ASV3147     -6.064987e-05 -6.356098e-05 -6.661232e-05 -6.981064e-05
## ASV3454     -2.720866e-04 -2.845268e-04 -2.975121e-04 -3.110645e-04
## ASV4411     -1.621854e-04 -1.698832e-04 -1.779452e-04 -1.863884e-04
## ASV3007      3.253706e-04  3.399988e-04  3.552446e-04  3.711305e-04
## ASV6151     -2.638605e-04 -2.756067e-04 -2.878405e-04 -3.005789e-04
## ASV0834      2.773660e-04  2.903114e-04  3.038477e-04  3.180006e-04
## ASV1231      3.981241e-04  4.163891e-04  4.354593e-04  4.553673e-04
## ASV0643      3.356515e-04  3.510273e-04  3.670788e-04  3.838329e-04
## ASV0924      9.720892e-06  1.017024e-05  1.063858e-05  1.112647e-05
## ASV3238     -1.657768e-04 -1.732055e-04 -1.809456e-04 -1.890081e-04
## ASV1276     -1.951464e-04 -2.040765e-04 -2.133981e-04 -2.231268e-04
## ASV5503     -5.278275e-04 -5.518331e-04 -5.768774e-04 -6.030005e-04
## ASV0404      2.125463e-04  2.224364e-04  2.327751e-04  2.435819e-04
## ASV3430      3.238844e-05  3.448537e-05  3.673048e-05  3.913474e-05
## ASV5401     -2.256141e-04 -2.360576e-04 -2.469703e-04 -2.583719e-04
## ASV3426     -4.809037e-04 -5.028844e-04 -5.258268e-04 -5.497692e-04
## ASV0777      2.862061e-04  2.993112e-04  3.129920e-04  3.272714e-04
## ASV11093    -1.923986e-04 -2.012226e-04 -2.104360e-04 -2.200544e-04
## ASV2170     -1.673982e-04 -1.748927e-04 -1.827006e-04 -1.908329e-04
## ASV3861      1.517405e-04  1.583653e-04  1.652515e-04  1.724069e-04
## ASV1723     -2.798588e-04 -2.927731e-04 -3.062637e-04 -3.203544e-04
## ASV2460     -1.585301e-04 -1.659229e-04 -1.736526e-04 -1.817339e-04
## ASV1218     -2.297508e-04 -2.400918e-04 -2.508712e-04 -2.621052e-04
## ASV0436      1.460840e-05  1.498334e-05  1.534804e-05  1.569969e-05
## ASV0919      1.958296e-04  2.047073e-04  2.139672e-04  2.236239e-04
## ASV0577      8.376455e-05  8.753873e-05  9.147284e-05  9.557272e-05
## ASV2517      2.227418e-04  2.327779e-04  2.432395e-04  2.541421e-04
## ASV2628     -2.709189e-04 -2.834810e-04 -2.966084e-04 -3.103247e-04
## ASV1743     -2.471653e-04 -2.587390e-04 -2.708445e-04 -2.835054e-04
## ASV1678     -2.132036e-04 -2.232670e-04 -2.338006e-04 -2.448257e-04
## ASV0315      2.777224e-04  2.905630e-04  3.039792e-04  3.179953e-04
## ASV0253      1.294541e-04  1.353518e-04  1.415053e-04  1.479244e-04
## ASV1363      3.511679e-04  3.668381e-04  3.831583e-04  4.001513e-04
## ASV0995     -1.934800e-04 -2.024300e-04 -2.117817e-04 -2.215521e-04
## ASV4185     -8.468215e-05 -8.834085e-05 -9.214088e-05 -9.608626e-05
## ASV0782      1.762977e-04  1.846433e-04  1.933816e-04  2.025308e-04
## ASV3240     -2.097738e-04 -2.195581e-04 -2.297893e-04 -2.404870e-04
## ASV1392     -3.805920e-04 -3.982891e-04 -4.167891e-04 -4.361268e-04
## ASV8488     -8.654984e-05 -9.058600e-05 -9.480700e-05 -9.922104e-05
## ASV2814     -1.411309e-04 -1.476749e-04 -1.545147e-04 -1.616631e-04
## ASV0678     -2.873592e-04 -3.009961e-04 -3.152769e-04 -3.302317e-04
## ASV1295     -2.009942e-04 -2.102756e-04 -2.199723e-04 -2.301016e-04
## ASV7517     -1.220765e-04 -1.274655e-04 -1.330730e-04 -1.389062e-04
## ASV2996     -3.917015e-04 -4.095676e-04 -4.282118e-04 -4.476647e-04
## ASV2882     -3.680372e-04 -3.847172e-04 -4.021147e-04 -4.202572e-04
## ASV1317      2.266114e-04  2.371119e-04  2.480845e-04  2.595491e-04
## ASV9106     -3.743984e-04 -3.916772e-04 -4.097277e-04 -4.285817e-04
## ASV9688     -3.562899e-04 -3.727221e-04 -3.898866e-04 -4.078137e-04
## ASV6181     -3.555752e-04 -3.719214e-04 -3.889914e-04 -4.068149e-04
## ASV2936      1.059411e-05  1.118363e-05  1.180848e-05  1.247091e-05
## ASV0192     -1.467234e-04 -1.532242e-04 -1.599893e-04 -1.670272e-04
## ASV2509     -1.796028e-04 -1.881349e-04 -1.970697e-04 -2.064259e-04
## ASV0863      6.222772e-04  6.501600e-04  6.792125e-04  7.094768e-04
## ASV2762     -1.600588e-04 -1.674644e-04 -1.752033e-04 -1.832896e-04
## ASV4904     -3.406754e-04 -3.563385e-04 -3.726954e-04 -3.897745e-04
## ASV0571      1.163590e-04  1.216008e-04  1.270667e-04  1.327654e-04
## ASV13304    -5.443625e-05 -5.728038e-05 -6.028133e-05 -6.344821e-05
## ASV6863     -7.730077e-05 -8.088047e-05 -8.462197e-05 -8.853228e-05
## ASV4844      2.861515e-05  3.026207e-05  3.201290e-05  3.387475e-05
## ASV10779    -3.739712e-04 -3.910741e-04 -4.089260e-04 -4.275569e-04
## ASV7921     -3.156582e-04 -3.302205e-04 -3.454327e-04 -3.613219e-04
## ASV8458     -3.292389e-04 -3.441571e-04 -3.597158e-04 -3.759393e-04
## ASV2593     -4.443933e-05 -4.615884e-05 -4.792452e-05 -4.973551e-05
## ASV4410     -1.789707e-04 -1.872638e-04 -1.959299e-04 -2.049849e-04
## ASV0593      4.594720e-04  4.810661e-04  5.036579e-04  5.272916e-04
## ASV2669      2.679113e-04  2.799443e-04  2.924837e-04  3.055476e-04
## ASV0868     -3.516973e-04 -3.679103e-04 -3.848455e-04 -4.025330e-04
## ASV3123     -1.240552e-04 -1.300067e-04 -1.362426e-04 -1.427762e-04
## ASV3482     -1.431660e-04 -1.496830e-04 -1.564824e-04 -1.635750e-04
## ASV2552     -3.954723e-04 -4.129599e-04 -4.311599e-04 -4.500957e-04
## ASV0723      4.503419e-04  4.702968e-04  4.910683e-04  5.126840e-04
## ASV0526     -2.992216e-04 -3.130009e-04 -3.273939e-04 -3.424262e-04
## ASV4623     -1.352024e-04 -1.415049e-04 -1.480944e-04 -1.549832e-04
## ASV2070     -4.170980e-04 -4.362469e-04 -4.562415e-04 -4.771163e-04
## ASV1198      1.059472e-05  1.103229e-05  1.148462e-05  1.195186e-05
## ASV3034      1.736810e-05  1.806492e-05  1.878388e-05  1.952518e-05
## ASV1208     -4.948317e-05 -5.173667e-05 -5.408842e-05 -5.654233e-05
## ASV4860      6.766922e-05  7.086185e-05  7.420279e-05  7.769863e-05
## ASV2493     -1.291720e-04 -1.351206e-04 -1.413341e-04 -1.478233e-04
## ASV4217     -8.892701e-05 -9.278177e-05 -9.678530e-05 -1.009416e-04
## ASV1516     -5.674314e-05 -5.977742e-05 -6.298561e-05 -6.637841e-05
## ASV1186      1.542537e-04  1.613688e-04  1.688014e-04  1.765647e-04
## ASV1906     -1.342075e-04 -1.404460e-04 -1.469674e-04 -1.537841e-04
## ASV8220     -2.119107e-05 -2.235408e-05 -2.358630e-05 -2.489221e-05
## ASV4227     -3.059067e-04 -3.199616e-04 -3.346385e-04 -3.499626e-04
## ASV1013      1.922120e-04  2.013778e-04  2.109785e-04  2.210342e-04
## ASV7952     -2.077605e-04 -2.176665e-04 -2.280438e-04 -2.389145e-04
## ASV5923     -2.362398e-04 -2.472471e-04 -2.587557e-04 -2.707870e-04
## ASV0190     -2.930026e-04 -3.062544e-04 -3.200728e-04 -3.344790e-04
## ASV0491     -3.226593e-05 -3.395678e-05 -3.574162e-05 -3.762605e-05
## ASV9535     -1.260873e-04 -1.318947e-04 -1.379598e-04 -1.442930e-04
## ASV9947     -9.469320e-05 -9.941293e-05 -1.043754e-04 -1.095937e-04
## ASV6518     -8.241895e-05 -8.621151e-05 -9.017262e-05 -9.430925e-05
## ASV1741     -8.482141e-05 -8.883148e-05 -9.302928e-05 -9.742335e-05
## ASV1874      1.594090e-04  1.664841e-04  1.738487e-04  1.815122e-04
## ASV2150      4.535936e-05  4.747120e-05  4.967899e-05  5.198686e-05
## ASV5262     -8.386909e-05 -8.764906e-05 -9.158950e-05 -9.569633e-05
## ASV1729     -3.025304e-04 -3.165661e-04 -3.312355e-04 -3.465655e-04
## ASV1522     -5.874854e-05 -6.183020e-05 -6.508027e-05 -6.850812e-05
## ASV3250      6.459404e-05  6.746378e-05  7.045159e-05  7.356152e-05
## ASV4338     -3.055449e-04 -3.196180e-04 -3.343171e-04 -3.496679e-04
## ASV1386      3.648621e-04  3.817374e-04  3.993696e-04  4.177904e-04
## ASV0694     -4.137662e-05 -4.346090e-05 -4.565468e-05 -4.796402e-05
## ASV2026      3.298965e-05  3.479880e-05  3.671470e-05  3.874408e-05
## ASV0191     -2.429185e-04 -2.538328e-04 -2.652069e-04 -2.770572e-04
## ASV1641      1.183989e-04  1.240099e-04  1.298833e-04  1.360310e-04
## ASV1326      5.914118e-04  6.185961e-04  6.469839e-04  6.766241e-04
## ASV4786     -1.777695e-05 -1.868551e-05 -1.964286e-05 -2.065181e-05
## ASV0342      1.487123e-04  1.557266e-04  1.630678e-04  1.707506e-04
## ASV3025     -1.718633e-04 -1.795669e-04 -1.875940e-04 -1.959562e-04
## ASV6533     -2.947172e-04 -3.080469e-04 -3.219473e-04 -3.364399e-04
## ASV1898      3.303130e-04  3.456201e-04  3.616147e-04  3.783256e-04
## ASV1940      1.873069e-04  1.959434e-04  2.049641e-04  2.143846e-04
## ASV4968     -3.420184e-04 -3.578651e-04 -3.744253e-04 -3.917292e-04
## ASV3401     -1.792725e-04 -1.875141e-04 -1.961209e-04 -2.051079e-04
## ASV3211      1.078174e-04  1.129751e-04  1.183792e-04  1.240412e-04
## ASV1489     -4.750005e-04 -4.967772e-04 -5.195120e-04 -5.432435e-04
## ASV4139     -2.785143e-04 -2.913503e-04 -3.047578e-04 -3.187606e-04
## ASV6059     -2.939501e-04 -3.075085e-04 -3.216720e-04 -3.364658e-04
## ASV0918      7.418791e-05  7.742437e-05  8.078828e-05  8.428343e-05
## ASV1449      2.856241e-04  2.987869e-04  3.125359e-04  3.268952e-04
## ASV5652     -1.962991e-04 -2.053253e-04 -2.147513e-04 -2.245935e-04
## ASV4091     -6.050586e-06 -5.962062e-06 -5.836022e-06 -5.667906e-06
## ASV7638     -1.822010e-04 -1.904508e-04 -1.990541e-04 -2.080245e-04
## ASV6525     -2.564867e-04 -2.679413e-04 -2.798744e-04 -2.923029e-04
## ASV8959     -2.654712e-04 -2.777621e-04 -2.906054e-04 -3.040243e-04
## ASV0699      2.028270e-04  2.121349e-04  2.218513e-04  2.319921e-04
## ASV2925      2.488401e-04  2.604169e-04  2.725190e-04  2.851692e-04
## ASV0618      5.502483e-05  5.771084e-05  6.052896e-05  6.348561e-05
## ASV2083      3.846607e-05  4.036148e-05  4.235245e-05  4.444392e-05
## ASV6192     -3.234459e-04 -3.382555e-04 -3.537153e-04 -3.698512e-04
## ASV8640     -3.656896e-04 -3.824490e-04 -3.999462e-04 -4.182107e-04
## ASV1103      1.500248e-04  1.567797e-04  1.638214e-04  1.711606e-04
## ASV4240     -1.773294e-05 -1.826442e-05 -1.879405e-05 -1.931955e-05
## ASV2180      9.518195e-05  9.953064e-05  1.040697e-04  1.088066e-04
## ASV9157     -2.344043e-04 -2.451187e-04 -2.563015e-04 -2.679713e-04
## ASV1307      4.603258e-04  4.816450e-04  5.039232e-04  5.272009e-04
## ASV4960     -1.146929e-04 -1.198220e-04 -1.251654e-04 -1.307305e-04
## ASV3930     -9.764181e-05 -1.020166e-04 -1.065755e-04 -1.113250e-04
## ASV1200     -2.014429e-04 -2.107905e-04 -2.205598e-04 -2.307687e-04
## ASV4676     -1.023502e-04 -1.070377e-04 -1.119313e-04 -1.170391e-04
## ASV6993     -3.802737e-04 -3.975026e-04 -4.154713e-04 -4.342077e-04
## ASV4813     -1.488843e-04 -1.557181e-04 -1.628534e-04 -1.703022e-04
## ASV4364     -4.904797e-04 -5.127607e-04 -5.360041e-04 -5.602468e-04
## ASV0141      1.946834e-04  2.030973e-04  2.118359e-04  2.209084e-04
## ASV3509      1.235583e-04  1.295519e-04  1.358405e-04  1.424387e-04
## ASV2751      2.070114e-04  2.165836e-04  2.265850e-04  2.370338e-04
## ASV4913     -2.120592e-04 -2.217367e-04 -2.318366e-04 -2.423756e-04
## ASV0138      5.253956e-04  5.495201e-04  5.747113e-04  6.010130e-04
## ASV7697     -1.476246e-04 -1.542182e-04 -1.610860e-04 -1.682376e-04
## ASV1602      7.551537e-05  7.865330e-05  8.189950e-05  8.525559e-05
## ASV5976     -2.943864e-04 -3.078718e-04 -3.219504e-04 -3.366459e-04
## ASV7525     -3.032426e-04 -3.171070e-04 -3.315788e-04 -3.466821e-04
## ASV4961      1.370264e-04  1.432714e-04  1.497871e-04  1.565841e-04
## ASV2546      3.697116e-04  3.861456e-04  4.032575e-04  4.210707e-04
## ASV0721     -2.234561e-04 -2.336865e-04 -2.443656e-04 -2.555113e-04
## ASV0542      2.053217e-04  2.147047e-04  2.244985e-04  2.347196e-04
## ASV3865      1.313919e-04  1.373020e-04  1.434617e-04  1.498803e-04
## ASV5571     -2.380777e-04 -2.486509e-04 -2.596582e-04 -2.711142e-04
## ASV6804      2.976564e-05  3.136141e-05  3.304903e-05  3.483422e-05
## ASV4424      2.206854e-04  2.308689e-04  2.415063e-04  2.526161e-04
## ASV3395      1.619901e-04  1.689709e-04  1.762197e-04  1.837440e-04
## ASV2394     -2.176214e-04 -2.276771e-04 -2.381830e-04 -2.491582e-04
## ASV8629     -2.176035e-04 -2.276575e-04 -2.381616e-04 -2.491347e-04
## ASV1018      1.970420e-04  2.061195e-04  2.156013e-04  2.255039e-04
## ASV6139     -4.410774e-04 -4.613610e-04 -4.825433e-04 -5.046608e-04
## ASV10411    -2.262491e-04 -2.366990e-04 -2.476163e-04 -2.590207e-04
## ASV3992     -8.795934e-05 -9.208502e-05 -9.640124e-05 -1.009165e-04
## ASV7131     -1.737345e-05 -1.820376e-05 -1.907410e-05 -1.998644e-05
## ASV3729     -3.703288e-05 -3.853173e-05 -4.007771e-05 -4.167091e-05
## ASV2197     -4.862328e-05 -5.080525e-05 -5.307917e-05 -5.544840e-05
## ASV2426     -2.272715e-04 -2.375335e-04 -2.482331e-04 -2.593867e-04
## ASV3669     -2.127377e-04 -2.227487e-04 -2.332250e-04 -2.441878e-04
## ASV1820      1.121533e-04  1.172453e-04  1.225565e-04  1.280954e-04
## ASV7081     -2.014078e-04 -2.107267e-04 -2.204644e-04 -2.306386e-04
## ASV7872     -2.559859e-04 -2.676412e-04 -2.798024e-04 -2.924891e-04
## ASV1670     -3.088590e-05 -3.213940e-05 -3.343282e-05 -3.476631e-05
## ASV0712      2.477654e-04  2.595993e-04  2.719976e-04  2.849871e-04
## ASV0474      3.804006e-04  3.971089e-04  4.144884e-04  4.325606e-04
## ASV1196      3.768688e-04  3.942641e-04  4.124364e-04  4.314182e-04
## ASV0845      2.369749e-04  2.477617e-04  2.590175e-04  2.707606e-04
## ASV12393    -4.805201e-04 -5.026863e-04 -5.258408e-04 -5.500244e-04
## ASV5867     -1.849071e-04 -1.934874e-04 -2.024544e-04 -2.118246e-04
## ASV17619    -6.984146e-05 -7.325333e-05 -7.683522e-05 -8.059584e-05
## ASV4686     -1.632888e-04 -1.709001e-04 -1.788586e-04 -1.871794e-04
## ASV3520     -2.659057e-04 -2.781261e-04 -2.908876e-04 -3.042124e-04
## ASV10800    -4.346428e-04 -4.547502e-04 -4.757598e-04 -4.977096e-04
## ASV2706      3.856263e-04  4.035418e-04  4.222677e-04  4.418388e-04
## ASV1227     -5.387275e-05 -5.625747e-05 -5.873939e-05 -6.132172e-05
## ASV2621      3.540920e-04  3.707543e-04  3.881903e-04  4.064348e-04
## ASV0460      7.908488e-05  8.289311e-05  8.688571e-05  9.107162e-05
## ASV1069     -2.896224e-04 -3.031124e-04 -3.172163e-04 -3.319606e-04
## ASV6939     -2.672767e-04 -2.794648e-04 -2.921837e-04 -3.054543e-04
## ASV2862     -3.714104e-04 -3.884638e-04 -4.062706e-04 -4.248613e-04
## ASV1021     -2.178200e-04 -2.276198e-04 -2.378340e-04 -2.484778e-04
## ASV3845      1.725536e-04  1.805573e-04  1.889213e-04  1.976608e-04
## ASV0732      1.512328e-04  1.583736e-04  1.658479e-04  1.736709e-04
## ASV10731     1.166184e-04  1.219111e-04  1.274316e-04  1.331887e-04
## ASV3378      1.392138e-04  1.453270e-04  1.516848e-04  1.582948e-04
## ASV7154      1.118991e-05  1.144368e-05  1.168412e-05  1.190840e-05
## ASV9876      6.480490e-05  6.788811e-05  7.111729e-05  7.449923e-05
## ASV0631      2.908798e-04  3.045288e-04  3.188084e-04  3.337469e-04
## ASV13027    -2.200189e-04 -2.303010e-04 -2.410544e-04 -2.522998e-04
## ASV2497     -2.200006e-04 -2.302809e-04 -2.410324e-04 -2.522757e-04
## ASV3966     -3.102262e-04 -3.247562e-04 -3.399550e-04 -3.558524e-04
## ASV2574      1.849807e-04  1.931947e-04  2.017454e-04  2.106443e-04
## ASV0545     -1.722253e-04 -1.803285e-04 -1.888066e-04 -1.976764e-04
## ASV8453     -1.953052e-04 -2.044237e-04 -2.139595e-04 -2.239310e-04
## ASV0221     -1.032866e-04 -1.080812e-04 -1.130925e-04 -1.183300e-04
## ASV3305      1.395233e-04  1.461256e-04  1.530378e-04  1.602745e-04
## ASV2647     -9.618270e-05 -1.004951e-04 -1.049883e-04 -1.096687e-04
## ASV5789     -4.453702e-04 -4.662280e-04 -4.880459e-04 -5.108665e-04
## ASV1731     -1.409015e-04 -1.470158e-04 -1.533685e-04 -1.599667e-04
## ASV3857      6.243441e-05  6.523770e-05  6.815924e-05  7.120334e-05
## ASV0405      2.623617e-04  2.741039e-04  2.863367e-04  2.990776e-04
## ASV0094     -3.003119e-04 -3.133388e-04 -3.268760e-04 -3.409390e-04
## ASV0158     -1.088521e-05 -1.117418e-05 -1.145785e-05 -1.173453e-05
## ASV5507     -2.626860e-04 -2.747799e-04 -2.874114e-04 -3.006029e-04
## ASV1023     -2.328943e-06 -2.113143e-06 -1.857235e-06 -1.556682e-06
## ASV0488     -1.708276e-04 -1.787210e-04 -1.869675e-04 -1.955819e-04
## ASV1459      1.435521e-04  1.499153e-04  1.565396e-04  1.634341e-04
## ASV4349     -4.316520e-05 -4.498080e-05 -4.686154e-05 -4.880872e-05
## ASV1172      4.429731e-04  4.631733e-04  4.842529e-04  5.062466e-04
## ASV10187    -1.162799e-04 -1.217905e-04 -1.275608e-04 -1.336027e-04
## ASV7227      6.880831e-05  7.203721e-05  7.541538e-05  7.894950e-05
## ASV10340     6.745836e-05  7.068529e-05  7.406713e-05  7.761135e-05
## ASV10821    -1.254660e-04 -1.312301e-04 -1.372490e-04 -1.435329e-04
## ASV13810    -1.254558e-04 -1.312189e-04 -1.372367e-04 -1.435194e-04
## ASV3230     -1.007481e-04 -1.053900e-04 -1.102383e-04 -1.153013e-04
## ASV5524      1.051781e-05  1.091420e-05  1.132008e-05  1.173509e-05
## ASV8742     -1.254379e-04 -1.311993e-04 -1.372153e-04 -1.434960e-04
## ASV9188      2.770735e-04  2.894577e-04  3.023574e-04  3.157907e-04
## ASV4658      1.403870e-04  1.468503e-04  1.536004e-04  1.606491e-04
## ASV7889      1.710130e-04  1.785577e-04  1.864089e-04  1.945769e-04
## ASV1466      3.973366e-05  4.186030e-05  4.410853e-05  4.648578e-05
## ASV1424     -8.091235e-05 -8.409428e-05 -8.736755e-05 -9.073136e-05
## ASV0098     -2.159594e-04 -2.260618e-04 -2.366268e-04 -2.476745e-04
## ASV0067     -3.453522e-04 -3.612501e-04 -3.778538e-04 -3.951924e-04
## ASV9434     -1.433998e-04 -1.499585e-04 -1.568045e-04 -1.639492e-04
## ASV3270     -5.664916e-05 -5.935206e-05 -6.218324e-05 -6.514864e-05
## ASV4518     -2.456747e-04 -2.568269e-04 -2.684597e-04 -2.805918e-04
## ASV7661     -2.311421e-04 -2.414540e-04 -2.521940e-04 -2.633768e-04
## ASV4223      2.638954e-05  2.763579e-05  2.893975e-05  3.030392e-05
## ASV3481      1.970925e-04  2.066856e-04  2.167536e-04  2.273206e-04
## ASV7819     -3.626931e-04 -3.793805e-04 -3.968087e-04 -4.150081e-04
## ASV3095     -1.550249e-05 -1.614924e-05 -1.681805e-05 -1.750911e-05
## ASV4476     -7.447354e-05 -7.800774e-05 -8.170887e-05 -8.558472e-05
## ASV1713      2.188264e-04  2.285234e-04  2.386172e-04  2.491211e-04
## ASV11165    -5.719912e-05 -5.967613e-05 -6.224839e-05 -6.491841e-05
## ASV2179      4.493305e-04  4.700566e-04  4.917069e-04  5.143197e-04
## ASV3747      3.852141e-04  4.029636e-04  4.215025e-04  4.408632e-04
## ASV1410      2.076503e-05  2.150888e-05  2.226667e-05  2.303730e-05
## ASV6069     -2.419838e-04 -2.531494e-04 -2.648136e-04 -2.769970e-04
## ASV1939      6.710804e-05  7.034203e-05  7.373299e-05  7.728858e-05
## ASV7865     -3.771808e-04 -3.945488e-04 -4.126881e-04 -4.316304e-04
## ASV4488     -3.466043e-04 -3.627412e-04 -3.796118e-04 -3.972479e-04
## ASV0938      2.741117e-04  2.866769e-04  2.997952e-04  3.134890e-04
## ASV7852     -2.081687e-04 -2.175901e-04 -2.274157e-04 -2.376609e-04
## ASV2503     -1.937169e-05 -2.044437e-05 -2.158234e-05 -2.279002e-05
## ASV2993     -2.968190e-04 -3.106095e-04 -3.250240e-04 -3.400892e-04
## ASV3752     -3.665321e-05 -3.829555e-05 -4.000677e-05 -4.178937e-05
## ASV2557     -3.023853e-04 -3.164491e-04 -3.311495e-04 -3.465136e-04
## ASV6522     -6.256878e-05 -6.536802e-05 -6.828405e-05 -7.132098e-05
## ASV0088     -2.249750e-04 -2.348161e-04 -2.450476e-04 -2.556815e-04
## ASV7935     -1.873286e-04 -1.958981e-04 -2.048434e-04 -2.141794e-04
## ASV0942     -2.384518e-04 -2.495419e-04 -2.611346e-04 -2.732514e-04
## ASV7709     -2.794388e-04 -2.919876e-04 -3.050649e-04 -3.186899e-04
## ASV4588     -1.431605e-04 -1.494565e-04 -1.560060e-04 -1.628172e-04
## ASV5765     -3.981767e-04 -4.164384e-04 -4.355047e-04 -4.554081e-04
## ASV3562     -2.049483e-05 -2.123260e-05 -2.198377e-05 -2.274707e-05
## ASV9076     -3.044013e-04 -3.184426e-04 -3.331105e-04 -3.484308e-04
## ASV4707     -3.396030e-04 -3.553092e-04 -3.717197e-04 -3.888641e-04
## ASV2188      2.417170e-04  2.530435e-04  2.648920e-04  2.772854e-04
## ASV0613      4.486075e-05  4.713347e-05  4.952487e-05  5.204124e-05
## ASV0663     -1.530449e-04 -1.601487e-04 -1.675735e-04 -1.753331e-04
## ASV3361     -3.040553e-04 -3.173272e-04 -3.311242e-04 -3.454624e-04
## ASV1478      3.372752e-04  3.526024e-04  3.685920e-04  3.852695e-04
## ASV0213      1.873545e-04  1.959001e-04  2.048180e-04  2.141228e-04
## ASV7674     -1.025581e-04 -1.071780e-04 -1.119942e-04 -1.170139e-04
## ASV2137     -1.099607e-04 -1.148765e-04 -1.199970e-04 -1.253296e-04
## ASV8246     -9.157437e-05 -9.572810e-05 -1.000610e-04 -1.045799e-04
## ASV0047     -2.903078e-04 -3.034021e-04 -3.170533e-04 -3.312822e-04
## ASV6117      9.851441e-06  1.041563e-05  1.101467e-05  1.165084e-05
## ASV3349     -5.545730e-05 -5.801578e-05 -6.068837e-05 -6.347980e-05
## ASV10881    -1.900949e-04 -1.988504e-04 -2.079949e-04 -2.175442e-04
## ASV6979     -1.284104e-04 -1.344023e-04 -1.406678e-04 -1.472187e-04
## ASV7930     -2.485964e-04 -2.599815e-04 -2.718669e-04 -2.842728e-04
## ASV7322      8.342640e-05  8.729582e-05  9.133958e-05  9.556505e-05
## ASV4927     -4.209192e-05 -4.413012e-05 -4.626795e-05 -4.851029e-05
## ASV9054     -1.388774e-04 -1.451827e-04 -1.517606e-04 -1.586217e-04
## ASV2692     -1.076142e-04 -1.128443e-04 -1.183287e-04 -1.240795e-04
## ASV1666     -7.386776e-05 -7.695592e-05 -8.015260e-05 -8.345966e-05
## ASV4728      1.596028e-04  1.667617e-04  1.742222e-04  1.819953e-04
## ASV3097      1.063177e-04  1.113312e-04  1.165785e-04  1.220704e-04
## ASV4962     -8.542554e-05 -8.965149e-05 -9.409165e-05 -9.875716e-05
## ASV5057      1.303637e-04  1.365473e-04  1.430229e-04  1.498040e-04
## ASV2639      2.358191e-04  2.469564e-04  2.586143e-04  2.708165e-04
## ASV1808     -2.813742e-05 -2.984351e-05 -3.166183e-05 -3.360012e-05
## ASV6333     -4.445617e-05 -4.674495e-05 -4.915790e-05 -5.170219e-05
## ASV4328     -1.056029e-04 -1.104504e-04 -1.155118e-04 -1.207958e-04
## ASV7707     -3.109029e-04 -3.250125e-04 -3.397296e-04 -3.550775e-04
## ASV11022    -3.016586e-04 -3.153047e-04 -3.295348e-04 -3.443709e-04
## ASV1469     -5.640988e-05 -5.896103e-05 -6.162162e-05 -6.439582e-05
## ASV3919     -1.040182e-04 -1.089498e-04 -1.141132e-04 -1.195191e-04
## ASV4038     -2.110610e-04 -2.207175e-04 -2.307976e-04 -2.413184e-04
## ASV4048      7.545032e-05  7.914076e-05  8.301466e-05  8.708129e-05
## ASV0634      8.721141e-05  9.131922e-05  9.561872e-05  1.001187e-04
## ASV1852     -2.377189e-04 -2.490070e-04 -2.608283e-04 -2.732074e-04
## ASV2505      1.788145e-04  1.870139e-04  1.955753e-04  2.045134e-04
## ASV1762     -2.744788e-04 -2.870207e-04 -3.001112e-04 -3.137721e-04
## ASV3761     -2.329313e-04 -2.436032e-04 -2.547445e-04 -2.663738e-04
## ASV0775     -3.950600e-04 -4.131252e-04 -4.319816e-04 -4.516604e-04
## ASV10911    -2.896992e-04 -3.029150e-04 -3.167070e-04 -3.310980e-04
## ASV1339     -4.926225e-05 -5.144350e-05 -5.371329e-05 -5.607445e-05
## ASV5214     -6.600388e-05 -6.894722e-05 -7.201223e-05 -7.520303e-05
## ASV4945      7.661359e-05  8.017301e-05  8.389312e-05  8.778069e-05
## ASV5624     -6.249920e-05 -6.514229e-05 -6.788112e-05 -7.071763e-05
## ASV3429     -3.566597e-05 -3.717785e-05 -3.874580e-05 -4.037124e-05
## ASV8416     -3.343468e-05 -3.521329e-05 -3.709249e-05 -3.907829e-05
## ASV2400     -3.573774e-04 -3.738113e-04 -3.909734e-04 -4.088935e-04
## ASV3388     -1.165473e-04 -1.220743e-04 -1.278615e-04 -1.339209e-04
## ASV7089      7.269589e-05  7.583946e-05  7.910376e-05  8.249199e-05
## ASV3396     -1.190934e-04 -1.244430e-04 -1.300174e-04 -1.358244e-04
## ASV0343      1.703700e-04  1.786648e-04  1.873693e-04  1.965041e-04
## ASV5505     -2.166264e-04 -2.267189e-04 -2.372711e-04 -2.483029e-04
## ASV6721     -1.022218e-04 -1.070776e-04 -1.121631e-04 -1.174890e-04
## ASV0537      8.921090e-05  9.387365e-05  9.879385e-05  1.039865e-04
## ASV7753     -2.809623e-04 -2.939443e-04 -3.075076e-04 -3.216763e-04
## ASV5022     -2.269384e-05 -2.398585e-05 -2.535729e-05 -2.681332e-05
## ASV1073      3.924964e-04  4.106473e-04  4.296120e-04  4.494248e-04
## ASV1347     -9.151817e-07 -1.009779e-06 -1.114266e-06 -1.229684e-06
## ASV15032     1.185935e-04  1.238627e-04  1.293478e-04  1.350559e-04
## ASV18213    -9.227939e-07 -1.018072e-06 -1.123298e-06 -1.239516e-06
## ASV20691     1.004366e-04  1.051447e-04  1.100693e-04  1.152196e-04
## ASV4260     -5.161412e-05 -5.401423e-05 -5.652396e-05 -5.914820e-05
## ASV4923      8.723170e-05  9.131316e-05  9.558135e-05  1.000444e-04
## ASV7995     -9.325754e-07 -1.028781e-06 -1.135021e-06 -1.252346e-06
## ASV8960      1.758380e-04  1.838853e-04  1.922849e-04  2.010507e-04
## ASV10682     1.334488e-04  1.392422e-04  1.452605e-04  1.515101e-04
## ASV11911    -9.511883e-07 -1.049088e-06 -1.157169e-06 -1.276496e-06
## ASV14296     2.114573e-04  2.209619e-04  2.308667e-04  2.411860e-04
## ASV2314      1.213290e-04  1.273444e-04  1.336661e-04  1.403099e-04
## ASV3819      1.364979e-04  1.426374e-04  1.490352e-04  1.557007e-04
## ASV4517     -9.794186e-07 -1.079962e-06 -1.190930e-06 -1.313407e-06
## ASV8941      2.611958e-04  2.733416e-04  2.860379e-04  2.993084e-04
## ASV1444      9.927711e-07  1.094576e-06  1.206921e-06  1.330903e-06
## ASV5959      4.762853e-05  4.977539e-05  5.201252e-05  5.434306e-05
## ASV3623     -1.205909e-04 -1.260341e-04 -1.317097e-04 -1.376267e-04
## ASV0260      1.455987e-04  1.523602e-04  1.594277e-04  1.668141e-04
## ASV4401     -9.642961e-05 -1.013114e-04 -1.064459e-04 -1.118462e-04
## ASV2891     -3.177653e-04 -3.325539e-04 -3.480146e-04 -3.641765e-04
## ASV2778     -7.149550e-05 -7.480565e-05 -7.826465e-05 -8.187877e-05
## ASV8744      1.398811e-04  1.460304e-04  1.524277e-04  1.590811e-04
## ASV1079      2.874283e-04  3.002592e-04  3.136250e-04  3.275447e-04
## ASV19688     2.178301e-05  2.297280e-05  2.423272e-05  2.556726e-05
## ASV4039      3.582584e-05  3.770157e-05  3.968168e-05  4.177239e-05
## ASV4982     -2.157723e-04 -2.256561e-04 -2.359746e-04 -2.467453e-04
## ASV1071     -2.157548e-04 -2.256369e-04 -2.359536e-04 -2.467223e-04
## ASV7666     -2.157372e-04 -2.256176e-04 -2.359325e-04 -2.466993e-04
## ASV0502      3.019311e-04  3.158710e-04  3.304337e-04  3.456453e-04
## ASV3624     -2.160703e-04 -2.259783e-04 -2.363228e-04 -2.471212e-04
## ASV0403      3.068610e-05  3.197457e-05  3.330925e-05  3.469108e-05
## ASV4939     -2.160507e-04 -2.259569e-04 -2.362994e-04 -2.470956e-04
## ASV6297     -2.588969e-04 -2.708952e-04 -2.834335e-04 -2.965349e-04
## ASV6343      2.302429e-04  2.402804e-04  2.507142e-04  2.615566e-04
## ASV0954     -4.847472e-05 -5.044429e-05 -5.247674e-05 -5.457233e-05
## ASV10225    -9.430660e-05 -9.876981e-05 -1.034410e-04 -1.083294e-04
## ASV1584      3.756906e-04  3.929221e-04  4.109129e-04  4.296937e-04
## ASV1803      1.377818e-04  1.438500e-04  1.501619e-04  1.567250e-04
## ASV2576     -3.756515e-04 -3.928793e-04 -4.108661e-04 -4.296426e-04
## ASV3252      2.443991e-04  2.557028e-04  2.675131e-04  2.798513e-04
## ASV3463     -3.756192e-04 -3.928440e-04 -4.108276e-04 -4.296005e-04
## ASV3822     -2.857919e-04 -2.991185e-04 -3.130534e-04 -3.276233e-04
## ASV4926     -1.515374e-04 -1.581284e-04 -1.649769e-04 -1.720904e-04
## ASV5564     -9.709935e-05 -1.015583e-04 -1.062146e-04 -1.110762e-04
## ASV5595     -5.666227e-05 -5.924936e-05 -6.194970e-05 -6.476783e-05
## ASV16463    -2.189692e-04 -2.291535e-04 -2.398001e-04 -2.509291e-04
## ASV6277      2.188908e-04  2.291974e-04  2.399823e-04  2.512669e-04
## ASV1344      2.189607e-04  2.291442e-04  2.397899e-04  2.509180e-04
## ASV1869      1.394956e-04  1.456687e-04  1.520927e-04  1.587755e-04
## ASV8155     -1.195669e-04 -1.248181e-04 -1.302792e-04 -1.359569e-04
## ASV2502     -2.210039e-04 -2.310957e-04 -2.416280e-04 -2.526182e-04
## ASV6742     -6.879921e-05 -7.172707e-05 -7.476337e-05 -7.791065e-05
## ASV3124     -1.435177e-04 -1.500612e-04 -1.568912e-04 -1.640192e-04
## ASV17042    -2.513536e-04 -2.628699e-04 -2.748925e-04 -2.874417e-04
## ASV0248      3.483838e-04  3.641986e-04  3.806961e-04  3.979025e-04
## ASV4557      5.953031e-05  6.262109e-05  6.587929e-05  6.931425e-05
## ASV3507     -3.822717e-04 -4.000041e-04 -4.185366e-04 -4.379032e-04
## ASV1870      2.808131e-05  2.937694e-05  3.073034e-05  3.214389e-05
## ASV2447     -1.842663e-04 -1.929097e-04 -2.019529e-04 -2.114137e-04
## ASV0347      2.991280e-04  3.130902e-04  3.276910e-04  3.429583e-04
## ASV1855     -1.372192e-04 -1.435831e-04 -1.502342e-04 -1.571848e-04
## ASV0568      1.030752e-04  1.077701e-04  1.126691e-04  1.177803e-04
## ASV1620     -1.836777e-04 -1.921530e-04 -2.010064e-04 -2.102534e-04
## ASV0101     -1.481351e-04 -1.545167e-04 -1.611427e-04 -1.680197e-04
## ASV7751      1.385375e-04  1.452494e-04  1.522907e-04  1.596780e-04
## ASV9033     -2.513462e-04 -2.630270e-04 -2.752370e-04 -2.879990e-04
## ASV3438     -7.293228e-05 -7.637146e-05 -7.997130e-05 -8.373916e-05
## ASV0637     -2.346366e-04 -2.454558e-04 -2.567569e-04 -2.685601e-04
## ASV1181     -1.734726e-04 -1.815435e-04 -1.899806e-04 -1.987995e-04
## ASV13480    -2.184439e-04 -2.285738e-04 -2.391604e-04 -2.502230e-04
## ASV14220    -2.184259e-04 -2.285541e-04 -2.391388e-04 -2.501993e-04
## ASV1448     -1.596051e-04 -1.670529e-04 -1.748409e-04 -1.829839e-04
## ASV1457      1.467128e-04  1.532518e-04  1.600611e-04  1.671501e-04
## ASV1645      1.059462e-04  1.109487e-04  1.161849e-04  1.216653e-04
## ASV2300     -1.421231e-04 -1.485822e-04 -1.553200e-04 -1.623473e-04
## ASV2533      2.187140e-04  2.286281e-04  2.389679e-04  2.497497e-04
## ASV5059      5.367872e-05  5.592586e-05  5.825259e-05  6.066041e-05
## ASV8871     -2.184187e-04 -2.285461e-04 -2.391299e-04 -2.501896e-04
## ASV1289     -2.337633e-04 -2.444141e-04 -2.555280e-04 -2.671230e-04
## ASV3983     -9.975073e-05 -1.044539e-04 -1.093762e-04 -1.145275e-04
## ASV10323    -7.924720e-05 -8.313017e-05 -8.720716e-05 -9.148806e-05
## ASV13279    -2.183726e-04 -2.284957e-04 -2.390747e-04 -2.501291e-04
## ASV7149     -2.183546e-04 -2.284760e-04 -2.390532e-04 -2.501055e-04
## ASV1691      4.167195e-05  4.365288e-05  4.572818e-05  4.790238e-05
## ASV1649      1.073824e-04  1.124102e-04  1.176679e-04  1.231653e-04
## ASV10120     3.161457e-05  3.314430e-05  3.474903e-05  3.643253e-05
## ASV8285     -2.787051e-04 -2.918473e-04 -3.056009e-04 -3.199934e-04
## ASV0037     -2.395787e-04 -2.507989e-04 -2.625353e-04 -2.748107e-04
## ASV1770      6.256696e-05  6.545615e-05  6.847492e-05  7.162875e-05
## ASV2252      5.985308e-05  6.261042e-05  6.549011e-05  6.849713e-05
## ASV7580      2.416702e-04  2.525012e-04  2.637865e-04  2.755422e-04
## ASV5643     -2.209828e-04 -2.311989e-04 -2.418730e-04 -2.530243e-04
## ASV2722     -7.112626e-05 -7.460357e-05 -7.825459e-05 -8.208828e-05
## ASV2662     -1.516499e-04 -1.587074e-04 -1.660861e-04 -1.738002e-04
## ASV0479     -3.457647e-04 -3.614911e-04 -3.778991e-04 -3.950151e-04
## ASV2009     -3.638335e-04 -3.801542e-04 -3.971603e-04 -4.148764e-04
## ASV3731     -2.452561e-04 -2.563612e-04 -2.679424e-04 -2.800177e-04
## ASV5497     -3.035320e-04 -3.174331e-04 -3.319452e-04 -3.470930e-04
## ASV6647      1.332071e-05  1.380352e-05  1.429522e-05  1.479493e-05
## ASV8974     -2.236851e-04 -2.338757e-04 -2.445088e-04 -2.556018e-04
## ASV15527     1.954098e-05  2.037728e-05  2.124509e-05  2.214522e-05
## ASV6705     -1.382285e-04 -1.450432e-04 -1.522025e-04 -1.597245e-04
## ASV0354      2.861897e-04  2.994157e-04  3.132340e-04  3.276693e-04
## ASV2707      6.527255e-05  6.808551e-05  7.100577e-05  7.403613e-05
## ASV11167    -3.759879e-04 -3.932548e-04 -4.112843e-04 -4.301072e-04
## ASV6393     -2.992156e-04 -3.130052e-04 -3.274086e-04 -3.424510e-04
## ASV3808     -2.132275e-04 -2.228192e-04 -2.328175e-04 -2.432375e-04
## ASV9337      2.943479e-05  3.060893e-05  3.181798e-05  3.306174e-05
## ASV5043     -3.069538e-04 -3.210917e-04 -3.358581e-04 -3.512788e-04
## ASV4189     -8.786702e-06 -9.030161e-06 -9.269400e-06 -9.502847e-06
## ASV1304     -1.165595e-04 -1.215124e-04 -1.266487e-04 -1.319728e-04
## ASV2105     -1.608876e-04 -1.683207e-04 -1.760867e-04 -1.841995e-04
## ASV2421     -5.601614e-05 -5.866703e-05 -6.144284e-05 -6.434943e-05
## ASV3170      2.572533e-04  2.692622e-04  2.818203e-04  2.949517e-04
## ASV5036      3.444923e-04  3.603282e-04  3.768655e-04  3.941328e-04
## ASV2286      2.173529e-04  2.273844e-04  2.378641e-04  2.488107e-04
## ASV3363      2.175398e-04  2.277976e-04  2.385337e-04  2.497700e-04
## ASV5759     -2.007216e-05 -2.108032e-05 -2.214154e-05 -2.325881e-05
## ASV5440     -1.507293e-04 -1.579466e-04 -1.655101e-04 -1.734363e-04
## ASV2050      2.495358e-04  2.605865e-04  2.720865e-04  2.840505e-04
## ASV4478      1.781872e-04  1.866269e-04  1.954636e-04  2.047155e-04
## ASV5725     -1.917497e-04 -2.004565e-04 -2.095393e-04 -2.190126e-04
## ASV1600     -5.570025e-05 -5.871135e-05 -6.189650e-05 -6.526636e-05
## ASV1654     -3.414023e-04 -3.569365e-04 -3.731445e-04 -3.900526e-04
## ASV3781     -1.472239e-04 -1.538127e-04 -1.606767e-04 -1.678255e-04
## ASV7144     -1.264204e-04 -1.320465e-04 -1.379043e-04 -1.440017e-04
## ASV12710    -4.639870e-05 -4.823623e-05 -5.012793e-05 -5.207354e-05
## ASV3317      1.721806e-04  1.800815e-04  1.883319e-04  1.969464e-04
## ASV3249     -3.372290e-04 -3.527164e-04 -3.688879e-04 -3.857713e-04
## ASV0669     -2.101025e-04 -2.194774e-04 -2.292418e-04 -2.394094e-04
## ASV0893      1.243298e-04  1.299900e-04  1.358958e-04  1.420568e-04
## ASV11060    -1.243197e-04 -1.299790e-04 -1.358838e-04 -1.420436e-04
## ASV3207      4.292463e-04  4.494193e-04  4.705266e-04  4.926100e-04
## ASV3498     -1.243184e-04 -1.299776e-04 -1.358823e-04 -1.420420e-04
## ASV4358      7.882095e-05  8.243304e-05  8.620394e-05  9.014001e-05
## ASV4806      2.135136e-04  2.233145e-04  2.335477e-04  2.442305e-04
## ASV4941      1.243129e-04  1.299716e-04  1.358757e-04  1.420348e-04
## ASV6998      3.726053e-05  3.896852e-05  4.075139e-05  4.261209e-05
## ASV7327     -1.243051e-04 -1.299631e-04 -1.358665e-04 -1.420247e-04
## ASV5112      2.515255e-04  2.632436e-04  2.754942e-04  2.883003e-04
## ASV5345     -1.242867e-04 -1.299429e-04 -1.358443e-04 -1.420005e-04
## ASV8911     -1.242766e-04 -1.299319e-04 -1.358323e-04 -1.419873e-04
## ASV5061      2.904980e-04  3.038211e-04  3.177309e-04  3.322511e-04
## ASV1968     -2.567790e-05 -2.698857e-05 -2.836943e-05 -2.982447e-05
## ASV4669     -1.242579e-04 -1.299115e-04 -1.358100e-04 -1.419630e-04
## ASV6209     -4.589020e-05 -4.783750e-05 -4.985580e-05 -5.194658e-05
## ASV6938      2.469355e-04  2.581106e-04  2.697638e-04  2.819132e-04
## ASV6987      1.370505e-04  1.430816e-04  1.493550e-04  1.558783e-04
## ASV7842     -1.242529e-04 -1.299061e-04 -1.358041e-04 -1.419566e-04
## ASV17950     8.153309e-08  8.813670e-08  9.520396e-08  1.027570e-07
## ASV3380     -3.618455e-04 -3.781804e-04 -3.952112e-04 -4.129641e-04
## ASV13740    -3.088607e-04 -3.231985e-04 -3.381844e-04 -3.538461e-04
## ASV4313     -1.811592e-04 -1.895350e-04 -1.982859e-04 -2.074277e-04
## ASV3891     -1.876085e-04 -1.957096e-04 -2.041231e-04 -2.128576e-04
## ASV3322     -2.191970e-04 -2.292979e-04 -2.398488e-04 -2.508683e-04
## ASV1668     -3.787285e-05 -3.970659e-05 -4.163114e-05 -4.365124e-05
## ASV1739      8.454008e-05  8.823408e-05  9.207405e-05  9.606436e-05
## ASV3194      1.746149e-04  1.826225e-04  1.909831e-04  1.997109e-04
## ASV0071     -2.621748e-04 -2.735579e-04 -2.853855e-04 -2.976706e-04
## ASV0695      1.268568e-04  1.328130e-04  1.390425e-04  1.455569e-04
## ASV3835     -9.901417e-05 -1.034588e-04 -1.080905e-04 -1.129158e-04
## ASV1876      1.025190e-04  1.073249e-04  1.123518e-04  1.176096e-04
## ASV4892     -3.041991e-04 -3.182626e-04 -3.329562e-04 -3.483066e-04
## ASV1212     -1.047508e-04 -1.095465e-04 -1.145532e-04 -1.197795e-04
## ASV2640      1.371752e-06  1.378158e-06  1.379685e-06  1.375668e-06
## ASV7236     -3.008216e-04 -3.148031e-04 -3.294182e-04 -3.446940e-04
## ASV2353     -8.430709e-05 -8.834323e-05 -9.257319e-05 -9.700631e-05
## ASV0276      3.650089e-04  3.812272e-04  3.981145e-04  4.156941e-04
## ASV2262     -1.114148e-04 -1.165343e-04 -1.218813e-04 -1.274654e-04
## ASV11201    -7.476945e-05 -7.833220e-05 -8.206425e-05 -8.597357e-05
## ASV0665      3.001667e-05  3.135114e-05  3.274116e-05  3.418876e-05
## ASV5238      2.968563e-05  3.054292e-05  3.139204e-05  3.222855e-05
## ASV6885     -1.650379e-04 -1.725776e-04 -1.804471e-04 -1.886594e-04
## ASV1844      6.749533e-05  7.089927e-05  7.448154e-05  7.825188e-05
## ASV0379      2.152622e-04  2.250949e-04  2.353572e-04  2.460660e-04
## ASV1040     -6.716210e-05 -7.009331e-05 -7.314028e-05 -7.630650e-05
## ASV7913     -1.249481e-04 -1.306950e-04 -1.366964e-04 -1.429628e-04
## ASV1197     -2.152307e-04 -2.250605e-04 -2.353195e-04 -2.460249e-04
## ASV5918      9.332830e-05  9.765524e-05  1.021774e-04  1.069030e-04
## ASV8045      4.856595e-05  5.099307e-05  5.354502e-05  5.622839e-05
## ASV16458    -2.134418e-05 -2.216342e-05 -2.300386e-05 -2.386497e-05
## ASV10827    -2.152181e-04 -2.250468e-04 -2.353046e-04 -2.460087e-04
## ASV3658     -2.152006e-04 -2.250277e-04 -2.352837e-04 -2.459858e-04
## ASV0073     -4.468692e-04 -4.676017e-04 -4.892693e-04 -5.119115e-04
## ASV1951     -9.086056e-05 -9.543210e-05 -1.002416e-04 -1.053017e-04
## ASV7630     -2.840503e-04 -2.970869e-04 -3.106988e-04 -3.249093e-04
## ASV9449     -1.518777e-04 -1.590650e-04 -1.665890e-04 -1.744651e-04
## ASV3944      3.048916e-04  3.188404e-04  3.334016e-04  3.485999e-04
## ASV1520     -4.122983e-04 -4.310644e-04 -4.506440e-04 -4.710686e-04
## ASV0307      3.192887e-04  3.341819e-04  3.497548e-04  3.660371e-04
## ASV12731    -8.116024e-05 -8.504563e-05 -8.911784e-05 -9.338591e-05
## ASV0282      3.205679e-04  3.355201e-04  3.511548e-04  3.675016e-04
## ASV2646      2.864596e-04  2.991859e-04  3.124354e-04  3.262256e-04
## ASV3536      2.283468e-04  2.388642e-04  2.498491e-04  2.613206e-04
## ASV10089    -2.096780e-04 -2.189930e-04 -2.286910e-04 -2.387850e-04
## ASV1185      2.096614e-04  2.189749e-04  2.286713e-04  2.387635e-04
## ASV1452      2.096448e-04  2.189569e-04  2.286516e-04  2.387421e-04
## ASV1700      2.096282e-04  2.189388e-04  2.286319e-04  2.387206e-04
## ASV6948     -2.096117e-04 -2.189207e-04 -2.286122e-04 -2.386991e-04
## ASV0389     -2.737253e-04 -2.859661e-04 -2.987175e-04 -3.119974e-04
## ASV11884     2.933775e-06  3.374165e-06  3.861198e-06  4.399101e-06
## ASV23165    -2.095755e-04 -2.188813e-04 -2.285692e-04 -2.386523e-04
## ASV2841      2.095589e-04  2.188632e-04  2.285496e-04  2.386309e-04
## ASV2949      2.095423e-04  2.188452e-04  2.285299e-04  2.386094e-04
## ASV4037      2.095258e-04  2.188271e-04  2.285102e-04  2.385879e-04
## ASV4477      2.095092e-04  2.188090e-04  2.284905e-04  2.385665e-04
## ASV4496      2.094927e-04  2.187910e-04  2.284708e-04  2.385450e-04
## ASV5784     -2.094761e-04 -2.187729e-04 -2.284511e-04 -2.385236e-04
## ASV6035      5.614743e-06  6.070210e-06  6.563608e-06  7.098034e-06
## ASV6232     -2.098352e-04 -2.191478e-04 -2.288424e-04 -2.389320e-04
## ASV1818      2.094436e-04  2.187375e-04  2.284126e-04  2.384816e-04
## ASV2595      2.094271e-04  2.187195e-04  2.283929e-04  2.384602e-04
## ASV2788     -2.751845e-05 -2.875480e-05 -3.004309e-05 -3.138515e-05
## ASV5018      2.094120e-04  2.187030e-04  2.283749e-04  2.384406e-04
## ASV0127      2.847183e-04  2.979789e-04  3.118428e-04  3.263363e-04
## ASV1527      6.785642e-06  7.183961e-06  7.607542e-06  8.058062e-06
## ASV1055      1.613784e-04  1.687767e-04  1.765004e-04  1.845626e-04
## ASV4791      1.029554e-04  1.070290e-04  1.112234e-04  1.155384e-04
## ASV0859      1.152164e-04  1.204082e-04  1.258195e-04  1.314583e-04
## ASV12971    -3.077462e-04 -3.219318e-04 -3.367488e-04 -3.522231e-04
## ASV16856    -3.077210e-04 -3.219042e-04 -3.367186e-04 -3.521900e-04
## ASV7321     -2.514318e-04 -2.630403e-04 -2.751672e-04 -2.878339e-04
## ASV8780     -3.076756e-04 -3.218546e-04 -3.366642e-04 -3.521306e-04
## ASV1569      2.253539e-04  2.356835e-04  2.464678e-04  2.577252e-04
## ASV3696      3.620413e-05  3.779187e-05  3.944261e-05  4.115823e-05
## ASV0624      4.122908e-04  4.311375e-04  4.508108e-04  4.713437e-04
## ASV0495      2.511391e-04  2.624632e-04  2.742684e-04  2.865723e-04
## ASV16971    -1.256833e-04 -1.314698e-04 -1.375133e-04 -1.438244e-04
## ASV6535      7.186608e-05  7.535739e-05  7.902077e-05  8.286486e-05
## ASV1897      2.947739e-04  3.081077e-04  3.220124e-04  3.365095e-04
## ASV2631     -3.849426e-05 -4.051694e-05 -4.265276e-05 -4.490853e-05
## ASV6204      9.919791e-05  1.038343e-04  1.086827e-04  1.137523e-04
## ASV3312     -1.896987e-04 -1.984751e-04 -2.076459e-04 -2.172278e-04
## ASV3360      1.203480e-04  1.260421e-04  1.320030e-04  1.382430e-04
## ASV3907      5.851653e-05  6.131621e-05  6.424979e-05  6.732361e-05
## ASV6090      6.008524e-05  6.287418e-05  6.578855e-05  6.883358e-05
## ASV8652     -6.894675e-05 -7.198216e-05 -7.513975e-05 -7.842338e-05
## ASV11129    -1.242785e-04 -1.299375e-04 -1.358424e-04 -1.420029e-04
## ASV11073    -1.242684e-04 -1.299264e-04 -1.358303e-04 -1.419897e-04
## ASV1840      4.158979e-04  4.347768e-04  4.544691e-04  4.750057e-04
## ASV2298      1.568312e-04  1.638715e-04  1.712086e-04  1.788533e-04
## ASV2420      3.730912e-04  3.903062e-04  4.082898e-04  4.270738e-04
## ASV6474      5.116589e-05  5.361374e-05  5.617830e-05  5.886502e-05
## ASV8475     -1.242550e-04 -1.299118e-04 -1.358144e-04 -1.419723e-04
## ASV8679     -1.242449e-04 -1.299008e-04 -1.358023e-04 -1.419591e-04
## ASV6527      1.186768e-04  1.242344e-04  1.300478e-04  1.361283e-04
## ASV2504     -2.004183e-05 -2.112087e-05 -2.226215e-05 -2.346949e-05
## ASV1093     -1.320069e-04 -1.380632e-04 -1.443863e-04 -1.509867e-04
## ASV0994      1.739048e-04  1.819204e-04  1.902929e-04  1.990372e-04
## ASV0092     -2.872395e-04 -3.007009e-04 -3.147822e-04 -3.295111e-04
## ASV2619      6.523701e-05  6.830239e-05  7.150947e-05  7.486454e-05
## ASV0121      3.615989e-04  3.775606e-04  3.941689e-04  4.114451e-04
## ASV0932      1.251544e-04  1.311079e-04  1.373428e-04  1.438723e-04
## ASV5229      2.080995e-04  2.175015e-04  2.273043e-04  2.375228e-04
## ASV6737      2.125968e-04  2.224304e-04  2.327048e-04  2.434386e-04
## ASV11213    -2.989830e-04 -3.123540e-04 -3.262828e-04 -3.407889e-04
## ASV1151      6.181024e-04  6.464590e-04  6.760659e-04  7.069736e-04
## ASV3813      3.222481e-04  3.367438e-04  3.518518e-04  3.675944e-04
## ASV5566      6.776522e-05  7.130057e-05  7.503131e-05  7.896893e-05
## ASV7529     -2.989467e-04 -3.123145e-04 -3.262398e-04 -3.407420e-04
## ASV2193      4.329164e-04  4.530816e-04  4.741644e-04  4.962045e-04
## ASV2349      3.976812e-04  4.160362e-04  4.352116e-04  4.552417e-04
## ASV2387      3.479992e-04  3.635098e-04  3.796624e-04  3.964792e-04
## ASV2699      2.912608e-04  3.049939e-04  3.193675e-04  3.344109e-04
## ASV3353      3.787601e-04  3.960201e-04  4.140301e-04  4.328193e-04
## ASV3621      2.012193e-04  2.101630e-04  2.194745e-04  2.291665e-04
## ASV3848      3.598797e-05  3.771536e-05  3.952605e-05  4.142407e-05
## ASV4440      5.309432e-06  5.825202e-06  6.388698e-06  7.004097e-06
## ASV4751      3.998081e-04  4.182603e-04  4.375366e-04  4.576714e-04
## ASV5115      1.715569e-04  1.795802e-04  1.879711e-04  1.967455e-04
## ASV5850     -2.988837e-04 -3.122457e-04 -3.261647e-04 -3.406602e-04
## ASV6293      1.854308e-04  1.939711e-04  2.028910e-04  2.122060e-04
## ASV6513      8.222879e-05  8.629018e-05  9.055756e-05  9.504175e-05
## ASV7628     -2.988642e-04 -3.122245e-04 -3.261415e-04 -3.406349e-04
## ASV7658      1.835404e-04  1.921399e-04  2.011342e-04  2.105405e-04
## ASV0776     -3.519231e-04 -3.677811e-04 -3.843113e-04 -4.015383e-04
## ASV10227    -2.988429e-04 -3.122013e-04 -3.261162e-04 -3.406073e-04
## ASV11965    -2.988191e-04 -3.121753e-04 -3.260879e-04 -3.405765e-04
## ASV1270     -1.008446e-04 -1.052270e-04 -1.097800e-04 -1.145085e-04
## ASV13123    -2.254640e-04 -2.354669e-04 -2.458797e-04 -2.567159e-04
## ASV5828      2.987725e-04  3.121244e-04  3.260324e-04  3.405160e-04
## ASV5920     -2.987487e-04 -3.120985e-04 -3.260041e-04 -3.404852e-04
## ASV6071      2.851447e-04  2.984108e-04  3.122796e-04  3.267769e-04
## ASV6723     -1.384333e-05 -1.429574e-05 -1.475151e-05 -1.520933e-05
## ASV6727     -2.987188e-04 -3.120659e-04 -3.259686e-04 -3.404463e-04
## ASV7759     -2.986950e-04 -3.120399e-04 -3.259403e-04 -3.404155e-04
## ASV0733      2.123990e-05  2.227260e-05  2.335686e-05  2.449540e-05
## ASV1655     -4.598186e-05 -4.835757e-05 -5.086281e-05 -5.350511e-05
## ASV0755     -4.451319e-04 -4.652449e-04 -4.862168e-04 -5.080797e-04
## ASV0796      1.803373e-04  1.880951e-04  1.961484e-04  2.045049e-04
## ASV0878      3.865071e-04  4.042192e-04  4.227105e-04  4.420121e-04
## ASV4988     -2.399690e-04 -2.509828e-04 -2.624825e-04 -2.744877e-04
## ASV0083     -2.744089e-04 -2.872067e-04 -3.005868e-04 -3.145742e-04
## ASV0273      1.280534e-04  1.335468e-04  1.392494e-04  1.451668e-04
## ASV3076      9.036367e-05  9.461187e-05  9.905692e-05  1.037077e-04
## ASV1513      7.387459e-05  7.722389e-05  8.071703e-05  8.435945e-05
## ASV5159     -1.836242e-05 -1.907276e-05 -1.980256e-05 -2.055160e-05
## ASV3422     -1.828211e-04 -1.913135e-04 -2.001904e-04 -2.094683e-04
## ASV12230    -2.582776e-05 -2.690591e-05 -2.802172e-05 -2.917580e-05
## ASV1694      3.768618e-04  3.938219e-04  4.115013e-04  4.299266e-04
## ASV1249      1.656124e-04  1.732499e-04  1.812275e-04  1.895593e-04
## ASV1697     -9.126324e-05 -9.537258e-05 -9.965610e-05 -1.041202e-04
## ASV4408     -2.226537e-04 -2.322429e-04 -2.422004e-04 -2.525366e-04
## ASV0095     -2.833836e-04 -2.967353e-04 -3.107085e-04 -3.253313e-04
## ASV0410      5.632164e-07  4.172285e-07  2.485695e-07  5.478846e-08
## ASV4642     -3.534144e-04 -3.697340e-04 -3.867830e-04 -4.045917e-04
## ASV4560     -1.008669e-06 -8.684571e-07 -7.046617e-07 -5.147125e-07
## ASV7586     -1.665856e-04 -1.743171e-04 -1.823976e-04 -1.908418e-04
## ASV4144     -1.875932e-04 -1.963619e-04 -2.055322e-04 -2.151218e-04
## ASV0327     -2.028227e-04 -2.120737e-04 -2.217275e-04 -2.318002e-04
## ASV0946     -1.702201e-04 -1.776241e-04 -1.853191e-04 -1.933139e-04
## ASV3254     -2.197206e-04 -2.299699e-04 -2.406868e-04 -2.518916e-04
## ASV0349      3.169863e-04  3.316492e-04  3.469695e-04  3.629748e-04
## ASV0472     -1.929583e-04 -2.017643e-04 -2.109540e-04 -2.205427e-04
## ASV1330      1.936226e-04  2.021771e-04  2.110785e-04  2.203379e-04
## ASV2605      2.064976e-04  2.160515e-04  2.260338e-04  2.364624e-04
## ASV2846     -1.183764e-04 -1.240363e-04 -1.299666e-04 -1.361804e-04
## ASV3982     -9.625340e-05 -1.007971e-04 -1.055531e-04 -1.105312e-04
## ASV4116     -2.196885e-04 -2.299347e-04 -2.406482e-04 -2.518493e-04
## ASV6048     -1.287070e-04 -1.347423e-04 -1.410557e-04 -1.476598e-04
## ASV1146      2.647260e-04  2.768683e-04  2.895453e-04  3.027784e-04
## ASV13362     1.527905e-05  1.589074e-05  1.652108e-05  1.717004e-05
## ASV1422     -2.196647e-04 -2.299086e-04 -2.406196e-04 -2.518179e-04
## ASV3640     -2.196465e-04 -2.298887e-04 -2.405977e-04 -2.517939e-04
## ASV5404      1.712517e-04  1.788493e-04  1.867586e-04  1.949903e-04
## ASV6118     -2.196343e-04 -2.298752e-04 -2.405830e-04 -2.517777e-04
## ASV1115     -1.874809e-04 -1.962255e-04 -2.053684e-04 -2.149269e-04
## ASV0888     -4.008622e-04 -4.193104e-04 -4.385776e-04 -4.586973e-04
## ASV4620      5.094057e-05  5.261312e-05  5.429988e-05  5.599625e-05
## ASV3099      7.919073e-05  8.300829e-05  8.701118e-05  9.120843e-05
## ASV7099      3.682481e-05  3.861385e-05  4.049092e-05  4.246040e-05
## ASV5892     -2.524320e-04 -2.640774e-04 -2.762422e-04 -2.889480e-04
## ASV6978     -2.515890e-04 -2.633136e-04 -2.755725e-04 -2.883889e-04
## ASV6555     -8.631179e-05 -9.076407e-05 -9.545797e-05 -1.004074e-04
## ASV0539     -3.164880e-04 -3.309016e-04 -3.459410e-04 -3.616306e-04
## ASV4665      8.822985e-05  9.199869e-05  9.590831e-05  9.996215e-05
## ASV2210      1.897358e-04  1.979550e-04  2.064959e-04  2.153683e-04
## ASV1329      2.004952e-04  2.098538e-04  2.196395e-04  2.298707e-04
## ASV7123     -2.909402e-04 -3.044870e-04 -3.186503e-04 -3.334567e-04
## ASV1260      1.975609e-06  2.108432e-06  2.250976e-06  2.403980e-06
## ASV1011      2.974450e-04  3.115183e-04  3.262516e-04  3.416752e-04
## ASV4233      8.133426e-05  8.517344e-05  8.919194e-05  9.339793e-05
## ASV1475      3.014639e-04  3.151963e-04  3.295268e-04  3.444791e-04
## ASV6099     -3.490897e-04 -3.649989e-04 -3.815997e-04 -3.989194e-04
## ASV1428      3.082865e-06  3.980597e-06  4.987127e-06  6.113078e-06
## ASV5101     -3.837903e-04 -4.017940e-04 -4.206295e-04 -4.403339e-04
## ASV11827    -1.729008e-04 -1.808978e-04 -1.892534e-04 -1.979828e-04
## ASV13899    -1.965929e-04 -2.056793e-04 -2.151726e-04 -2.250898e-04
## ASV21259    -2.309240e-04 -2.416531e-04 -2.528681e-04 -2.645898e-04
## ASV6635     -1.143411e-04 -1.197620e-04 -1.254385e-04 -1.313824e-04
## ASV9922     -3.094769e-04 -3.238296e-04 -3.388297e-04 -3.545047e-04
## ASV2869      3.795056e-05  3.964455e-05  4.140849e-05  4.324472e-05
## ASV1740      2.017572e-04  2.109387e-04  2.205182e-04  2.305109e-04
## ASV4406     -3.120653e-04 -3.266656e-04 -3.419367e-04 -3.579082e-04
## ASV5586     -2.662782e-04 -2.788308e-04 -2.919688e-04 -3.057187e-04
## ASV3255     -1.054147e-04 -1.102409e-04 -1.152791e-04 -1.205378e-04
## ASV12281    -1.477345e-04 -1.543880e-04 -1.613240e-04 -1.685532e-04
## ASV5388     -2.910013e-04 -3.039888e-04 -3.175155e-04 -3.316002e-04
## ASV17660    -2.996603e-04 -3.135149e-04 -3.279906e-04 -3.431136e-04
## ASV0159      1.644496e-04  1.717314e-04  1.793132e-04  1.872058e-04
## ASV2734     -4.440054e-04 -4.643518e-04 -4.855935e-04 -5.077665e-04
## ASV2049      3.380387e-05  3.537221e-05  3.701166e-05  3.872533e-05
## ASV2465      2.095579e-05  2.159344e-05  2.223031e-05  2.286386e-05
## ASV2147      1.371226e-04  1.428576e-04  1.487962e-04  1.549423e-04
## ASV3113     -4.274168e-05 -4.466677e-05 -4.667283e-05 -4.876270e-05
## ASV0622     -3.150939e-04 -3.297247e-04 -3.450162e-04 -3.609964e-04
## ASV0437     -3.156412e-04 -3.301157e-04 -3.452278e-04 -3.610030e-04
## ASV6385     -3.454444e-04 -3.614439e-04 -3.781629e-04 -3.956318e-04
## ASV3699     -3.137975e-04 -3.285607e-04 -3.440096e-04 -3.601754e-04
## ASV2208      3.137713e-04  3.285319e-04  3.439781e-04  3.601409e-04
## ASV1053      7.156961e-05  7.485428e-05  7.828433e-05  8.186572e-05
## ASV8468     -6.998984e-05 -7.313288e-05 -7.640822e-05 -7.982063e-05
## ASV0951     -2.626844e-04 -2.746711e-04 -2.871807e-04 -3.002338e-04
## ASV0278      3.752796e-04  3.921677e-04  4.097703e-04  4.281137e-04
## ASV0914     -1.965518e-04 -2.055547e-04 -2.149529e-04 -2.247622e-04
## ASV0737      2.926272e-04  3.054243e-04  3.187296e-04  3.325588e-04
## ASV2038      4.235467e-04  4.426898e-04  4.626507e-04  4.834603e-04
## ASV2171      2.567268e-04  2.678737e-04  2.794558e-04  2.914856e-04
## ASV2607      2.925739e-04  3.053662e-04  3.186664e-04  3.324899e-04
## ASV3143      2.219357e-04  2.314944e-04  2.414190e-04  2.517194e-04
## ASV3187     -3.139546e-04 -3.277190e-04 -3.420334e-04 -3.569150e-04
## ASV3810      2.925105e-04  3.052972e-04  3.185912e-04  3.324081e-04
## ASV5060     -1.798605e-04 -1.875798e-04 -1.955921e-04 -2.039051e-04
## ASV5325      2.924752e-04  3.052588e-04  3.185494e-04  3.323627e-04
## ASV6905     -2.924524e-04 -3.052340e-04 -3.185224e-04 -3.323333e-04
## ASV7597     -2.924297e-04 -3.052092e-04 -3.184955e-04 -3.323040e-04
## ASV9652     -2.924070e-04 -3.051845e-04 -3.184685e-04 -3.322747e-04
## ASV2634      2.923842e-04  3.051597e-04  3.184416e-04  3.322454e-04
## ASV3065      2.923615e-04  3.051350e-04  3.184147e-04  3.322161e-04
## ASV3331      2.923388e-04  3.051102e-04  3.183877e-04  3.321868e-04
## ASV7434     -2.923161e-04 -3.050855e-04 -3.183608e-04 -3.321575e-04
## ASV7720      4.767597e-05  5.033993e-05  5.316440e-05  5.615965e-05
## ASV8414     -2.922956e-04 -3.050633e-04 -3.183367e-04 -3.321313e-04
## ASV12139    -2.922729e-04 -3.050386e-04 -3.183098e-04 -3.321020e-04
## ASV1824      2.847946e-04  2.972164e-04  3.101285e-04  3.235458e-04
## ASV2094      2.885679e-04  3.011670e-04  3.142647e-04  3.278762e-04
## ASV2770     -6.705610e-05 -7.046713e-05 -7.405846e-05 -7.783995e-05
## ASV3505     -1.406079e-04 -1.463552e-04 -1.522925e-04 -1.584219e-04
## ASV1935      2.921994e-04  3.049587e-04  3.182229e-04  3.320076e-04
## ASV5764     -2.921767e-04 -3.049340e-04 -3.181960e-04 -3.319784e-04
## ASV6806      1.872637e-04  1.961068e-04  2.053630e-04  2.150508e-04
## ASV6942     -2.921557e-04 -3.049110e-04 -3.181711e-04 -3.319512e-04
## ASV1166      3.211811e-04  3.352833e-04  3.499509e-04  3.652019e-04
## ASV1664      2.285158e-04  2.387385e-04  2.493878e-04  2.604785e-04
## ASV2568      2.921118e-04  3.048633e-04  3.181191e-04  3.318947e-04
## ASV3525      2.920892e-04  3.048386e-04  3.180922e-04  3.318654e-04
## ASV4965     -3.499571e-04 -3.656108e-04 -3.819186e-04 -3.989039e-04
## ASV6607     -1.803621e-04 -1.879287e-04 -1.957655e-04 -2.038778e-04
## ASV7187      9.918722e-05  1.036764e-04  1.083574e-04  1.132371e-04
## ASV0388     -2.903483e-04 -3.040889e-04 -3.184748e-04 -3.335358e-04
## ASV1420      2.019304e-06  2.205302e-06  2.407906e-06  2.628528e-06
## ASV14293     9.438104e-05  9.894808e-05  1.037385e-04  1.087634e-04
## ASV17785     2.011610e-06  2.196833e-06  2.398586e-06  2.618268e-06
## ASV7678      1.777269e-05  1.815887e-05  1.852330e-05  1.886167e-05
## ASV2253      7.962693e-05  8.347025e-05  8.750053e-05  9.172693e-05
## ASV4150      1.593754e-04  1.664413e-04  1.737971e-04  1.814524e-04
## ASV3836     -3.688273e-04 -3.857316e-04 -4.033803e-04 -4.218035e-04
## ASV16231    -3.027502e-04 -3.169073e-04 -3.317141e-04 -3.471993e-04
## ASV2730      6.105486e-06  6.390151e-06  6.688047e-06  6.999806e-06
## ASV2072      1.715401e-04  1.789876e-04  1.867259e-04  1.947635e-04
## ASV2160      4.612110e-05  4.847891e-05  5.096340e-05  5.358183e-05
## ASV5013      5.599727e-05  5.833181e-05  6.074712e-05  6.324434e-05
## ASV2586      1.007043e-04  1.052694e-04  1.100302e-04  1.149940e-04
## ASV1442      7.904493e-05  8.270551e-05  8.652932e-05  9.052291e-05
## ASV3101      1.122964e-04  1.170215e-04  1.219155e-04  1.269817e-04
## ASV3323     -9.403827e-05 -9.848568e-05 -1.031371e-04 -1.080011e-04
## ASV1812      2.880131e-04  3.005733e-04  3.136292e-04  3.271958e-04
## ASV6120     -3.418354e-05 -3.592291e-05 -3.775464e-05 -3.968386e-05
## ASV2565      6.284246e-05  6.557179e-05  6.840771e-05  7.135332e-05
## ASV6687      3.231742e-05  3.376505e-05  3.527326e-05  3.684419e-05
## ASV5357     -2.525414e-04 -2.641477e-04 -2.762673e-04 -2.889211e-04
## ASV9383      1.254366e-04  1.309998e-04  1.367913e-04  1.428188e-04
## ASV11753    -2.161338e-04 -2.260470e-04 -2.363971e-04 -2.472016e-04
## ASV11512    -5.993396e-05 -6.268011e-05 -6.554718e-05 -6.854006e-05
## ASV2791     -9.534625e-06 -1.008665e-05 -1.067357e-05 -1.129776e-05
## ASV0664     -4.570367e-04 -4.778829e-04 -4.996366e-04 -5.223334e-04
## ASV3436      4.732036e-05  4.978582e-05  5.238812e-05  5.513549e-05
## ASV5755      3.111866e-04  3.253110e-04  3.400438e-04  3.554083e-04
## ASV10970    -3.060811e-04 -3.201105e-04 -3.347568e-04 -3.500448e-04
## ASV11798    -1.561686e-04 -1.633203e-04 -1.707859e-04 -1.785781e-04
## ASV18193    -3.060452e-04 -3.200711e-04 -3.347138e-04 -3.499978e-04
## ASV2548      3.218342e-04  3.363435e-04  3.514700e-04  3.672366e-04
## ASV3901      3.478602e-04  3.635448e-04  3.798967e-04  3.969407e-04
## ASV5197      5.967454e-06  5.874549e-06  5.745555e-06  5.576355e-06
## ASV5859      1.544191e-04  1.613966e-04  1.686727e-04  1.762586e-04
## ASV6240     -3.060309e-04 -3.200554e-04 -3.346966e-04 -3.499789e-04
## ASV7281      3.060059e-04  3.200281e-04  3.346667e-04  3.499463e-04
## ASV7635      1.719610e-04  1.799285e-04  1.882541e-04  1.969531e-04
## ASV8822     -3.059858e-04 -3.200062e-04 -3.346427e-04 -3.499201e-04
## ASV4810     -6.492337e-05 -6.769708e-05 -7.057347e-05 -7.355480e-05
## ASV5308      3.201859e-04  3.348759e-04  3.502137e-04  3.662254e-04
## ASV2749     -3.506555e-04 -3.668497e-04 -3.837678e-04 -4.014399e-04
## ASV0298      2.699140e-05  2.862106e-05  3.035878e-05  3.221224e-05
## ASV2597     -3.287999e-04 -3.440299e-04 -3.599450e-04 -3.765739e-04
## ASV5758     -1.369156e-04 -1.432163e-04 -1.497971e-04 -1.566693e-04
## ASV9987     -3.474685e-04 -3.634782e-04 -3.802002e-04 -3.976638e-04
## ASV0971      7.008575e-05  7.295190e-05  7.591530e-05  7.897759e-05
## ASV0627     -3.392315e-04 -3.549729e-04 -3.714250e-04 -3.886180e-04
## ASV1758      3.072860e-04  3.213763e-04  3.360875e-04  3.514447e-04
## ASV4559      1.338287e-06  1.448447e-06  1.567542e-06  1.696243e-06
## ASV11400    -1.268730e-05 -1.313431e-05 -1.358811e-05 -1.404771e-05
## ASV11559    -3.090710e-04 -3.233868e-04 -3.383467e-04 -3.539780e-04
## ASV3943     -3.090455e-04 -3.233589e-04 -3.383161e-04 -3.539445e-04
## ASV10389     5.772135e-05  6.021129e-05  6.279605e-05  6.547803e-05
## ASV5168      2.730412e-04  2.852477e-04  2.979633e-04  3.112058e-04
## ASV5724      1.907715e-04  1.996233e-04  2.088743e-04  2.185415e-04
## ASV6337      5.987427e-05  6.236185e-05  6.493509e-05  6.759526e-05
## ASV11063     1.726222e-04  1.801821e-04  1.880430e-04  1.962144e-04
## ASV4279     -3.296388e-05 -3.447745e-05 -3.605780e-05 -3.770762e-05
## ASV7660     -1.281001e-04 -1.341144e-04 -1.404069e-04 -1.469900e-04
## ASV8218     -1.280894e-04 -1.341027e-04 -1.403941e-04 -1.469759e-04
## ASV3574      5.023989e-04  5.258629e-04  5.504006e-04  5.760589e-04
## ASV12050    -1.280914e-04 -1.341049e-04 -1.403965e-04 -1.469785e-04
## ASV3897      1.143365e-04  1.194219e-04  1.247172e-04  1.302297e-04
## ASV3856     -3.859403e-04 -4.036632e-04 -4.221682e-04 -4.414868e-04
## ASV3024     -1.221441e-04 -1.280434e-04 -1.342288e-04 -1.407140e-04
## ASV8715     -3.002245e-04 -3.140275e-04 -3.284419e-04 -3.434928e-04
## ASV6917     -1.268433e-04 -1.322920e-04 -1.379480e-04 -1.438169e-04
## ASV1132      3.109208e-04  3.254751e-04  3.406986e-04  3.566212e-04
## ASV3583      1.564198e-04  1.638115e-04  1.715497e-04  1.796503e-04
## ASV0328      4.959076e-04  5.187784e-04  5.426695e-04  5.676232e-04
## ASV0915     -1.663486e-04 -1.741665e-04 -1.823470e-04 -1.909064e-04
## ASV2677      1.683179e-04  1.763093e-04  1.846780e-04  1.934415e-04
## ASV0599      1.699061e-04  1.775548e-04  1.855287e-04  1.938400e-04
## ASV0283     -4.520910e-04 -4.728100e-04 -4.944409e-04 -5.170205e-04
## ASV1028      1.872927e-04  1.960867e-04  2.052873e-04  2.149126e-04
## ASV0523      3.410221e-04  3.568722e-04  3.734399e-04  3.907561e-04
## ASV8201     -2.078217e-04 -2.175050e-04 -2.276284e-04 -2.382109e-04
## ASV2795     -6.518221e-05 -6.815090e-05 -7.124862e-05 -7.448043e-05
## ASV3563     -6.507884e-05 -6.804258e-05 -7.113511e-05 -7.436148e-05
## ASV1553     -1.185712e-04 -1.237277e-04 -1.290866e-04 -1.346537e-04
## ASV7155     -3.336035e-05 -3.526366e-05 -3.728236e-05 -3.942361e-05
## ASV0365      4.361607e-04  4.560246e-04  4.767521e-04  4.983768e-04
## ASV8583     -2.998483e-04 -3.135134e-04 -3.277726e-04 -3.426490e-04
## ASV5400      1.596257e-05  1.674144e-05  1.755825e-05  1.841478e-05
## ASV5908      2.317788e-04  2.420853e-04  2.528160e-04  2.639852e-04
## ASV2075      1.313550e-04  1.374746e-04  1.438724e-04  1.505604e-04
## ASV2520     -2.620208e-04 -2.742414e-04 -2.870196e-04 -3.003797e-04
## ASV9596     -1.286866e-04 -1.343655e-04 -1.402744e-04 -1.464209e-04
## ASV1131     -4.290695e-05 -4.461936e-05 -4.638522e-05 -4.820489e-05
## ASV0579     -8.519127e-05 -8.906803e-05 -9.311320e-05 -9.733340e-05
## ASV0288     -4.167540e-04 -4.356602e-04 -4.553812e-04 -4.759481e-04
## ASV4053      6.855895e-05  7.133343e-05  7.419716e-05  7.715089e-05
## ASV1736     -2.226258e-04 -2.328347e-04 -2.434931e-04 -2.546191e-04
## ASV1254      2.290761e-04  2.392940e-04  2.499365e-04  2.610184e-04
## ASV9038     -3.644162e-04 -3.812645e-04 -3.988669e-04 -4.172550e-04
## ASV4746      3.325850e-04  3.481497e-04  3.644299e-04  3.814574e-04
## ASV5803      1.260783e-04  1.319028e-04  1.379880e-04  1.443448e-04
## ASV0525      1.449175e-05  1.519347e-05  1.592956e-05  1.670173e-05
## ASV1974      1.919345e-04  2.004271e-04  2.092653e-04  2.184603e-04
## ASV1827      3.217389e-04  3.361914e-04  3.512532e-04  3.669464e-04
## ASV30780     1.573000e-05  1.633046e-05  1.694592e-05  1.757587e-05
## ASV9342      1.197407e-05  1.266492e-05  1.339963e-05  1.418125e-05
## ASV21626    -3.043411e-04 -3.182369e-04 -3.327389e-04 -3.478708e-04
## ASV1232     -2.152511e-04 -2.249962e-04 -2.351593e-04 -2.457560e-04
## ASV5578     -2.174915e-04 -2.275323e-04 -2.380216e-04 -2.489781e-04
## ASV5868      2.281972e-04  2.383312e-04  2.488826e-04  2.598657e-04
## ASV13625    -9.454965e-05 -9.881505e-05 -1.032616e-04 -1.078960e-04
## ASV3614      3.501787e-05  3.646253e-05  3.795632e-05  3.949994e-05
## ASV2128      1.965507e-04  2.057028e-04  2.152707e-04  2.252724e-04
## ASV5086      4.293105e-05  4.484446e-05  4.683680e-05  4.891073e-05
## ASV6614     -2.174816e-04 -2.275214e-04 -2.380097e-04 -2.489650e-04
## ASV9451     -2.174637e-04 -2.275019e-04 -2.379883e-04 -2.489416e-04
## ASV9533     -2.174459e-04 -2.274823e-04 -2.379669e-04 -2.489182e-04
## ASV10697     2.777381e-06  3.036951e-06  3.320245e-06  3.629357e-06
## ASV1473     -1.018469e-04 -1.063062e-04 -1.109426e-04 -1.157616e-04
## ASV1414     -6.453091e-05 -6.756617e-05 -7.074113e-05 -7.406185e-05
## ASV1567     -6.334805e-05 -6.650379e-05 -6.982227e-05 -7.331231e-05
## ASV6395     -2.193053e-04 -2.295196e-04 -2.401989e-04 -2.513633e-04
## ASV2366      8.798756e-05  9.167781e-05  9.549870e-05  9.945257e-05
## ASV2537      8.780565e-05  9.155720e-05  9.544911e-05  9.948486e-05
## ASV5378     -2.192965e-04 -2.295099e-04 -2.401882e-04 -2.513515e-04
## ASV5929     -2.307958e-04 -2.415356e-04 -2.527633e-04 -2.645000e-04
## ASV6360      1.830254e-04  1.912094e-04  1.997341e-04  2.086113e-04
## ASV7916     -3.724763e-05 -3.913213e-05 -4.111667e-05 -4.320693e-05
## ASV13322     7.285497e-05  7.636082e-05  8.003651e-05  8.389030e-05
## ASV6207     -2.773961e-04 -2.901423e-04 -3.034521e-04 -3.173485e-04
## ASV8823     -2.208054e-04 -2.310086e-04 -2.416683e-04 -2.528037e-04
## ASV1379      3.072908e-04  3.214351e-04  3.362072e-04  3.516327e-04
## ASV3259     -3.072656e-04 -3.214076e-04 -3.361771e-04 -3.515998e-04
## ASV18748     9.128712e-07  1.086713e-06  1.280800e-06  1.497158e-06
## ASV3570      6.681406e-05  6.992285e-05  7.317270e-05  7.656964e-05
## ASV0790     -6.621389e-05 -6.866087e-05 -7.116328e-05 -7.371885e-05
## ASV5149     -2.807646e-04 -2.935779e-04 -3.069496e-04 -3.209016e-04
## ASV1730     -2.897976e-04 -3.030760e-04 -3.169380e-04 -3.314072e-04
## ASV3488     -2.373928e-05 -2.475331e-05 -2.580536e-05 -2.689640e-05
## ASV5486     -3.142552e-04 -3.290645e-04 -3.445642e-04 -3.607859e-04
## ASV1319      4.939116e-05  5.105313e-05  5.273460e-05  5.443174e-05
## ASV15328    -2.160792e-04 -2.259894e-04 -2.363363e-04 -2.471377e-04
## ASV5994      3.120189e-04  3.263692e-04  3.413553e-04  3.570032e-04
## ASV4992     -2.502138e-05 -2.609875e-05 -2.721707e-05 -2.837738e-05
## ASV1788     -3.409000e-04 -3.560519e-04 -3.718283e-04 -3.882506e-04
## ASV3264     -3.903322e-06 -3.897141e-06 -3.873412e-06 -3.829819e-06
## ASV4895      1.465304e-05  1.524230e-05  1.584980e-05  1.647558e-05
## ASV9218     -5.422797e-06 -5.475606e-06 -5.512530e-06 -5.531245e-06
## ASV0736     -6.625248e-06 -7.112301e-06 -7.637806e-06 -8.204881e-06
## ASV0916      2.160365e-04  2.259428e-04  2.362856e-04  2.470824e-04
## ASV15761    -2.160189e-04 -2.259235e-04 -2.362645e-04 -2.470593e-04
## ASV4191      2.691943e-04  2.813070e-04  2.939320e-04  3.070881e-04
## ASV3268     -5.519900e-05 -5.757530e-05 -6.004173e-05 -6.260054e-05
## ASV15321    -3.521935e-05 -3.700494e-05 -3.888522e-05 -4.086552e-05
## ASV0708     -2.158488e-04 -2.259301e-04 -2.364728e-04 -2.474971e-04
## ASV4100      2.544791e-05  2.646818e-05  2.751989e-05  2.860305e-05
## ASV1627      1.734535e-04  1.808903e-04  1.886100e-04  1.966202e-04
## ASV7045     -1.911357e-04 -1.999534e-04 -2.091639e-04 -2.187832e-04
## ASV3271      4.579711e-05  4.742381e-05  4.908234e-05  5.077085e-05
## ASV6200     -3.327681e-05 -3.487668e-05 -3.655438e-05 -3.831381e-05
## ASV2727     -2.256776e-04 -2.364034e-04 -2.476358e-04 -2.593981e-04
## ASV3523     -2.987854e-04 -3.124293e-04 -3.266685e-04 -3.415265e-04
## ASV2259      2.016515e-04  2.109154e-04  2.205891e-04  2.306894e-04
## ASV0181      2.963201e-04  3.097721e-04  3.238043e-04  3.384389e-04
## ASV1680      5.936118e-04  6.207908e-04  6.491630e-04  6.787760e-04
## ASV0176      6.038365e-05  6.300624e-05  6.573048e-05  6.855917e-05
## ASV10458    -2.168912e-04 -2.268767e-04 -2.373059e-04 -2.481969e-04
## ASV10658    -2.168734e-04 -2.268573e-04 -2.372846e-04 -2.481736e-04
## ASV16807    -2.168557e-04 -2.268378e-04 -2.372633e-04 -2.481503e-04
## ASV2113     -2.168379e-04 -2.268184e-04 -2.372421e-04 -2.481271e-04
## ASV2403      2.223782e-04  2.324734e-04  2.430036e-04  2.539855e-04
## ASV2484     -2.168305e-04 -2.268103e-04 -2.372332e-04 -2.481173e-04
## ASV8876     -2.168128e-04 -2.267909e-04 -2.372119e-04 -2.480941e-04
## ASV0386      3.171797e-04  3.319777e-04  3.474515e-04  3.636304e-04
## ASV0351      8.748836e-05  9.137627e-05  9.542369e-05  9.963595e-05
## ASV4942     -1.235476e-04 -1.292004e-04 -1.351015e-04 -1.412609e-04
## ASV5128     -9.574047e-05 -1.002063e-04 -1.048755e-04 -1.097570e-04
## ASV3496      1.074671e-04  1.126936e-04  1.181785e-04  1.239348e-04
## ASV3329      3.157341e-04  3.304250e-04  3.457828e-04  3.618361e-04
## ASV7878     -2.160744e-04 -2.259810e-04 -2.363235e-04 -2.471196e-04
## ASV8251     -8.208324e-05 -8.584403e-05 -8.976991e-05 -9.386743e-05
## ASV15958    -7.094251e-05 -7.424353e-05 -7.769423e-05 -8.130101e-05
## ASV7972     -3.089266e-04 -3.232252e-04 -3.381657e-04 -3.537753e-04
## ASV2088      3.089012e-04  3.231973e-04  3.381352e-04  3.537419e-04
## ASV3054     -1.453998e-04 -1.521319e-04 -1.591662e-04 -1.665154e-04
## ASV4494     -3.088656e-04 -3.231583e-04 -3.380926e-04 -3.536952e-04
## ASV0087     -5.853982e-04 -6.121899e-04 -6.401566e-04 -6.693454e-04
## ASV1614     -2.393311e-04 -2.502669e-04 -2.616805e-04 -2.735908e-04
## ASV3037     -1.325881e-04 -1.386830e-04 -1.450479e-04 -1.516935e-04
## ASV6615     -3.477589e-05 -3.654059e-05 -3.839868e-05 -4.035535e-05
## ASV1027      8.982694e-05  9.387807e-05  9.810108e-05  1.025023e-04
## ASV2754     -5.609802e-05 -5.886336e-05 -6.176835e-05 -6.482023e-05
## ASV0536     -4.380565e-05 -4.592073e-05 -4.813880e-05 -5.046491e-05
## ASV2318     -9.278519e-05 -9.716034e-05 -1.017397e-04 -1.065326e-04
## ASV5954      1.841865e-04  1.923187e-04  2.007808e-04  2.095839e-04
## ASV9028      1.297182e-04  1.357088e-04  1.419670e-04  1.485039e-04
## ASV6600     -2.193987e-04 -2.296201e-04 -2.403069e-04 -2.514792e-04
## ASV1923     -5.775855e-05 -6.034548e-05 -6.304030e-05 -6.584676e-05
## ASV4034     -4.245669e-05 -4.466780e-05 -4.700084e-05 -4.946296e-05
## ASV9933     -2.193734e-04 -2.295924e-04 -2.402764e-04 -2.514458e-04
## ASV1575      4.109726e-05  4.285539e-05  4.468015e-05  4.657335e-05
## ASV7812     -3.728618e-04 -3.899662e-04 -4.078241e-04 -4.264661e-04
## ASV0515      2.400316e-04  2.507856e-04  2.619899e-04  2.736605e-04
## ASV1149     -2.726083e-05 -2.886231e-05 -3.056608e-05 -3.237908e-05
## ASV3791      1.003106e-04  1.050563e-04  1.100249e-04  1.152265e-04
## ASV4065     -3.487396e-04 -3.647681e-04 -3.815055e-04 -3.989804e-04
## ASV10631    -1.976150e-05 -2.083456e-05 -2.197076e-05 -2.317418e-05
## ASV2359     -3.446772e-04 -3.599085e-04 -3.757598e-04 -3.922518e-04
## ASV3206     -2.170558e-04 -2.270590e-04 -2.375079e-04 -2.484207e-04
## ASV4415      1.766828e-04  1.848245e-04  1.933281e-04  2.022085e-04
## ASV4467     -1.555702e-04 -1.626596e-04 -1.700572e-04 -1.777751e-04
## ASV5598      2.661789e-04  2.787537e-04  2.919175e-04  3.056975e-04
## ASV5910     -2.394672e-04 -2.505227e-04 -2.620724e-04 -2.741371e-04
## ASV9494     -2.170073e-04 -2.270060e-04 -2.374498e-04 -2.483571e-04
## ASV6548     -1.772171e-04 -1.853514e-04 -1.938451e-04 -2.027127e-04
## ASV8669     -2.169752e-04 -2.269709e-04 -2.374114e-04 -2.483151e-04
## ASV0674      1.348631e-04  1.408250e-04  1.470287e-04  1.534820e-04
## ASV0061     -6.512211e-05 -6.875295e-05 -7.260130e-05 -7.668092e-05
## ASV0310     -1.342222e-04 -1.402090e-04 -1.464471e-04 -1.529457e-04
## ASV0582      4.136624e-05  4.305699e-05  4.480386e-05  4.660753e-05
## ASV0739      4.111674e-04  4.303180e-04  4.503391e-04  4.712682e-04
## ASV1557      1.717273e-04  1.798789e-04  1.884155e-04  1.973551e-04
## ASV0146      3.838193e-04  4.008658e-04  4.186131e-04  4.370851e-04
## ASV3832      3.919962e-04  4.096847e-04  4.281257e-04  4.473468e-04
## ASV0734      8.771187e-05  9.182628e-05  9.612983e-05  1.006308e-04
## ASV3036     -2.873700e-04 -3.007713e-04 -3.147841e-04 -3.294353e-04
## ASV0240      7.722173e-05  8.070154e-05  8.432896e-05  8.810940e-05
## ASV2513     -4.312087e-04 -4.508043e-04 -4.712468e-04 -4.925689e-04
## ASV1118     -1.148773e-04 -1.203397e-04 -1.260599e-04 -1.320498e-04
## ASV7286     -2.164182e-04 -2.263591e-04 -2.367394e-04 -2.475771e-04
## ASV1077      2.890636e-04  3.021189e-04  3.157312e-04  3.299215e-04
## ASV1255     -2.163802e-04 -2.263175e-04 -2.366939e-04 -2.475274e-04
## ASV1794     -1.312261e-05 -1.375821e-05 -1.442484e-05 -1.512400e-05
## ASV2439     -2.163632e-04 -2.262990e-04 -2.366737e-04 -2.475053e-04
## ASV2467     -2.163455e-04 -2.262796e-04 -2.366525e-04 -2.474821e-04
## ASV3346     -2.163279e-04 -2.262603e-04 -2.366314e-04 -2.474590e-04
## ASV3973     -2.163102e-04 -2.262409e-04 -2.366102e-04 -2.474359e-04
## ASV4521      9.555845e-05  9.985678e-05  1.043362e-04  1.090031e-04
## ASV1909     -2.572070e-04 -2.692891e-04 -2.819304e-04 -2.951560e-04
## ASV3855     -1.938723e-04 -2.026998e-04 -2.119102e-04 -2.215184e-04
## ASV0810      2.587382e-04  2.706958e-04  2.831886e-04  2.962388e-04
## ASV1765      3.085636e-04  3.229413e-04  3.379738e-04  3.536894e-04
## ASV0763      1.677375e-04  1.754263e-04  1.834534e-04  1.918326e-04
## ASV0302     -1.828900e-04 -1.911619e-04 -1.997875e-04 -2.087798e-04
## ASV2643     -2.490409e-04 -2.600552e-04 -2.715200e-04 -2.834507e-04
## ASV0440      9.665448e-05  1.012008e-04  1.059569e-04  1.109320e-04
## ASV4899     -1.752809e-04 -1.830528e-04 -1.911423e-04 -1.995599e-04
## ASV0287     -1.065346e-04 -1.114938e-04 -1.166788e-04 -1.220995e-04
## ASV3220      1.333151e-04  1.395529e-04  1.460764e-04  1.528980e-04
## ASV1007     -7.663603e-05 -8.000368e-05 -8.350600e-05 -8.714712e-05
## ASV2929     -4.888220e-05 -5.094287e-05 -5.307777e-05 -5.528839e-05
## ASV1496     -1.836953e-04 -1.923164e-04 -2.013358e-04 -2.107714e-04
## ASV4975      8.027407e-05  8.399596e-05  8.788503e-05  9.194822e-05
## ASV4392     -1.108204e-05 -1.139273e-05 -1.169820e-05 -1.199640e-05
## ASV4653     -2.187620e-04 -2.289237e-04 -2.395452e-04 -2.506463e-04
## ASV0230     -1.120112e-04 -1.172751e-04 -1.227826e-04 -1.285447e-04
## ASV0840      1.578238e-04  1.651406e-04  1.727873e-04  1.807780e-04
## ASV4132     -4.716355e-05 -4.943207e-05 -5.181042e-05 -5.430394e-05
## ASV3344      1.644107e-04  1.718034e-04  1.795084e-04  1.875370e-04
## ASV12096    -2.218696e-04 -2.322092e-04 -2.430187e-04 -2.543185e-04
## ASV1550      7.394453e-05  7.704941e-05  8.026519e-05  8.359404e-05
## ASV3542     -3.290008e-04 -3.444479e-04 -3.606071e-04 -3.775099e-04
## ASV8795     -1.273413e-04 -1.332812e-04 -1.394919e-04 -1.459852e-04
## ASV2532     -6.878543e-06 -7.259396e-06 -7.663104e-06 -8.091149e-06
## ASV3087      5.268986e-05  5.501354e-05  5.743112e-05  5.994560e-05
## ASV9476     -1.273339e-04 -1.332730e-04 -1.394830e-04 -1.459754e-04
## ASV13721    -1.273233e-04 -1.332615e-04 -1.394703e-04 -1.459615e-04
## ASV3842      2.096309e-04  2.190310e-04  2.288255e-04  2.390285e-04
## ASV1663      3.773275e-04  3.942607e-04  4.119060e-04  4.302892e-04
## ASV0432      8.869790e-05  9.267186e-05  9.681227e-05  1.011251e-04
## ASV4356      3.734149e-04  3.905348e-04  4.084085e-04  4.270664e-04
## ASV4524      9.086743e-05  9.520565e-05  9.975093e-05  1.045131e-04
## ASV0169     -1.843994e-04 -1.930656e-04 -2.021331e-04 -2.116195e-04
## ASV0368     -1.584968e-04 -1.659386e-04 -1.737242e-04 -1.818687e-04
## ASV2603      7.424987e-08  7.668190e-08  7.869425e-08  8.015904e-08
## ASV3777      2.090340e-04  2.186798e-04  2.287559e-04  2.392801e-04
## ASV3978      1.814672e-04  1.897291e-04  1.983489e-04  2.073404e-04
## ASV0413     -1.495591e-04 -1.565764e-04 -1.639173e-04 -1.715962e-04
## ASV0997     -4.540442e-08 -4.511248e-08 -4.414819e-08 -4.236102e-08
## ASV1195     -4.540393e-08 -4.511305e-08 -4.415016e-08 -4.236484e-08
## ASV2522     -9.838588e-05 -1.029011e-04 -1.076157e-04 -1.125375e-04
## ASV4733      1.797086e-04  1.880229e-04  1.967099e-04  2.057851e-04
## ASV1063      3.151654e-04  3.300566e-04  3.456453e-04  3.619636e-04
## ASV0612     -4.018157e-04 -4.205941e-04 -4.402335e-04 -4.607719e-04
## ASV1903     -3.151078e-04 -3.299934e-04 -3.455761e-04 -3.618877e-04
## ASV3576     -9.184047e-05 -9.637599e-05 -1.011419e-04 -1.061502e-04
## ASV4285     -2.245470e-04 -2.350562e-04 -2.460478e-04 -2.575429e-04
## ASV3406     -1.167680e-04 -1.221807e-04 -1.278374e-04 -1.337485e-04
## ASV2379     -2.168643e-04 -2.263515e-04 -2.362162e-04 -2.464703e-04
## ASV0528      2.742453e-04  2.869582e-04  3.002434e-04  3.141251e-04
## ASV6190     -3.565360e-05 -3.738923e-05 -3.921060e-05 -4.112199e-05
## ASV1537     -2.826926e-06 -2.854085e-06 -2.872475e-06 -2.880761e-06
## ASV16780    -2.439048e-04 -2.550773e-04 -2.667410e-04 -2.789156e-04
## ASV0477      6.057235e-04  6.336477e-04  6.628158e-04  6.932790e-04
## ASV1499      1.388124e-04  1.456236e-04  1.527755e-04  1.602853e-04
## ASV14736     1.050981e-04  1.098892e-04  1.148890e-04  1.201059e-04
## ASV0179     -8.738256e-05 -9.145842e-05 -9.572015e-05 -1.001758e-04
## ASV3153      7.443626e-06  8.051342e-06  8.710997e-06  9.427066e-06
## ASV0266      2.830959e-04  2.962541e-04  3.100090e-04  3.243863e-04
## ASV0761      4.190754e-04  4.381816e-04  4.581197e-04  4.789226e-04
## ASV0269     -4.121738e-05 -4.335629e-05 -4.561314e-05 -4.799497e-05
## ASV7259     -7.948813e-05 -8.343780e-05 -8.758867e-05 -9.195122e-05
## ASV2067     -8.876022e-05 -9.271402e-05 -9.683140e-05 -1.011180e-04
## ASV2985     -2.486124e-04 -2.600812e-04 -2.720602e-04 -2.845702e-04
## ASV0975     -3.769367e-04 -3.944525e-04 -4.127614e-04 -4.318973e-04
## ASV2240      2.241273e-04  2.341833e-04  2.446626e-04  2.555807e-04
## ASV2297      7.282725e-05  7.589568e-05  7.907503e-05  8.236769e-05
## ASV2657      9.427290e-05  9.844347e-05  1.027844e-04  1.073014e-04
## ASV3784      3.396406e-06  3.711185e-06  4.054329e-06  4.428280e-06
## ASV4333      3.395869e-06  3.710571e-06  4.053628e-06  4.427480e-06
## ASV5547      1.934092e-04  2.018605e-04  2.106474e-04  2.197805e-04
## ASV5813      7.849665e-05  8.194960e-05  8.554137e-05  8.927637e-05
## ASV8049      9.412908e-05  9.838913e-05  1.028320e-04  1.074646e-04
## ASV8661     -3.405481e-06 -3.721040e-06 -4.065027e-06 -4.439887e-06
## ASV9510      1.099853e-04  1.149394e-04  1.201035e-04  1.254853e-04
## ASV1401      5.772964e-05  6.030717e-05  6.299211e-05  6.578827e-05
## ASV1417     -1.151711e-04 -1.200047e-04 -1.250113e-04 -1.301944e-04
## ASV2169      4.014016e-04  4.198185e-04  4.390481e-04  4.591235e-04
## ASV5354     -3.417451e-06 -3.734128e-06 -4.079334e-06 -4.455525e-06
## ASV5379     -3.416911e-06 -3.733511e-06 -4.078630e-06 -4.454721e-06
## ASV6078     -3.416371e-06 -3.732894e-06 -4.077925e-06 -4.453916e-06
## ASV6417      2.453316e-04  2.564275e-04  2.679981e-04  2.800613e-04
## ASV8304      1.777684e-04  1.856680e-04  1.938931e-04  2.024546e-04
## ASV8766     -3.436996e-06 -3.755391e-06 -4.102457e-06 -4.480660e-06
## ASV10861     7.422667e-05  7.748155e-05  8.086610e-05  8.438432e-05
## ASV2057      3.969419e-04  4.151773e-04  4.342192e-04  4.541002e-04
## ASV4499      1.391186e-04  1.451565e-04  1.514294e-04  1.579439e-04
## ASV7415      4.402138e-05  4.606996e-05  4.821088e-05  5.044795e-05
## ASV2475     -1.702020e-04 -1.780682e-04 -1.862869e-04 -1.948729e-04
## ASV3517     -2.785502e-04 -2.916295e-04 -3.053139e-04 -3.196308e-04
## ASV1864      1.867291e-04  1.951400e-04  2.039073e-04  2.130440e-04
## ASV2756      2.157039e-04  2.255784e-04  2.358863e-04  2.466451e-04
## ASV0778      2.156863e-04  2.255591e-04  2.358653e-04  2.466222e-04
## ASV3201      4.930993e-05  5.184574e-05  5.451901e-05  5.733771e-05
## ASV3358      2.156714e-04  2.255429e-04  2.358476e-04  2.466028e-04
## ASV5681     -2.156538e-04 -2.255237e-04 -2.358266e-04 -2.465798e-04
## ASV7256      1.045103e-04  1.093647e-04  1.144400e-04  1.197461e-04
## ASV1704     -2.204610e-04 -2.304817e-04 -2.409350e-04 -2.518375e-04
## ASV4445      3.466542e-04  3.619365e-04  3.778374e-04  3.943773e-04
## ASV8649     -2.156178e-04 -2.254844e-04 -2.357837e-04 -2.465330e-04
## ASV0597      2.241034e-04  2.343519e-04  2.450493e-04  2.562135e-04
## ASV0861      2.852874e-04  2.982197e-04  3.117080e-04  3.257734e-04
## ASV2423      3.461197e-04  3.618715e-04  3.783055e-04  3.954481e-04
## ASV1548      1.686288e-04  1.759634e-04  1.835849e-04  1.915014e-04
## ASV2564      2.880030e-04  3.009695e-04  3.144843e-04  3.285673e-04
## ASV2999      4.790563e-04  5.005537e-04  5.229551e-04  5.462928e-04
## ASV4543     -1.729691e-04 -1.810863e-04 -1.895788e-04 -1.984635e-04
## ASV8452      1.644071e-04  1.716867e-04  1.792631e-04  1.871460e-04
## ASV17287    -3.466006e-05 -3.644297e-05 -3.832279e-05 -4.030518e-05
## ASV3503     -2.213515e-04 -2.317598e-04 -2.426511e-04 -2.540474e-04
## ASV4727     -3.812395e-05 -4.012779e-05 -4.224389e-05 -4.447902e-05
## ASV5995     -1.883175e-04 -1.971584e-04 -2.064084e-04 -2.160857e-04
## ASV1665     -6.030534e-05 -6.313267e-05 -6.609033e-05 -6.918412e-05
## ASV2690     -2.817268e-04 -2.947166e-04 -3.082854e-04 -3.224571e-04
## ASV2823     -2.288704e-05 -2.389088e-05 -2.493492e-05 -2.602047e-05
## ASV5241     -3.767085e-04 -3.940736e-04 -4.122116e-04 -4.311541e-04
## ASV5473     -1.082944e-04 -1.134334e-04 -1.188152e-04 -1.244511e-04
## ASV2785      4.890403e-05  5.126628e-05  5.374364e-05  5.634175e-05
## ASV6645     -1.591512e-04 -1.664233e-04 -1.740132e-04 -1.819334e-04
## ASV0562      6.426067e-05  6.700917e-05  6.985964e-05  7.281435e-05
## ASV1163      6.507429e-05  6.812335e-05  7.131245e-05  7.464771e-05
## ASV1825      1.227133e-04  1.282417e-04  1.340040e-04  1.400086e-04
## ASV3795      2.710459e-04  2.834065e-04  2.963059e-04  3.097652e-04
## ASV3869     -6.087778e-05 -6.384186e-05 -6.695290e-05 -7.021840e-05
## ASV4330      2.089820e-04  2.185701e-04  2.285809e-04  2.390315e-04
## ASV6754      7.944125e-05  8.308354e-05  8.688600e-05  9.085502e-05
## ASV4598     -2.151652e-06 -2.356496e-06 -2.580559e-06 -2.825600e-06
## ASV2100      1.604196e-04  1.675785e-04  1.750349e-04  1.827994e-04
## ASV3518      7.973426e-05  8.328289e-05  8.697746e-05  9.082282e-05
## ASV3823      3.304184e-04  3.454056e-04  3.610381e-04  3.773403e-04
## ASV7357      2.028351e-04  2.121012e-04  2.217723e-04  2.318643e-04
## ASV7403     -2.592090e-04 -2.709987e-04 -2.832987e-04 -2.961287e-04
## ASV2934     -1.106058e-05 -1.148548e-05 -1.192132e-05 -1.236779e-05
## ASV5277     -1.349364e-04 -1.410702e-04 -1.474689e-04 -1.541427e-04
## ASV0281     -3.975871e-04 -4.157371e-04 -4.346796e-04 -4.544460e-04
## ASV11181    -1.479608e-04 -1.550268e-04 -1.624312e-04 -1.701904e-04
## ASV0254     -5.144325e-05 -5.339195e-05 -5.538803e-05 -5.742980e-05
## ASV0201     -6.880843e-05 -7.217283e-05 -7.570541e-05 -7.941489e-05
## ASV3656     -1.706728e-04 -1.788996e-04 -1.875267e-04 -1.965738e-04
## ASV7994     -3.072664e-04 -3.214262e-04 -3.362165e-04 -3.516631e-04
## ASV3584     -9.956505e-05 -1.037166e-04 -1.080151e-04 -1.124633e-04
## ASV2157      3.157679e-04  3.299807e-04  3.447960e-04  3.602361e-04
## ASV2935     -4.065484e-05 -4.253509e-05 -4.449965e-05 -4.655204e-05
## ASV9024     -2.876784e-04 -3.007112e-04 -3.143035e-04 -3.284764e-04
## ASV7711      1.723401e-04  1.804721e-04  1.889841e-04  1.978933e-04
## ASV11330    -2.181673e-04 -2.282742e-04 -2.388360e-04 -2.498721e-04
## ASV1875      1.922110e-04  2.010534e-04  2.102888e-04  2.199332e-04
## ASV5861      1.441065e-04  1.509113e-04  1.580341e-04  1.654895e-04
## ASV11562     1.262558e-05  1.323411e-05  1.387198e-05  1.454057e-05
## ASV18559    -2.181615e-04 -2.282678e-04 -2.388290e-04 -2.498645e-04
## ASV4384      2.112543e-04  2.212067e-04  2.316225e-04  2.425226e-04
## ASV1302      4.304862e-04  4.496150e-04  4.695333e-04  4.902685e-04
## ASV4673     -2.865981e-04 -2.999676e-04 -3.139466e-04 -3.285616e-04
## ASV1956      4.791898e-05  4.990657e-05  5.196474e-05  5.409510e-05
## ASV3286      1.999035e-04  2.093292e-04  2.191941e-04  2.295183e-04
## ASV4866     -3.135365e-04 -3.282773e-04 -3.437022e-04 -3.598420e-04
## ASV3129     -1.538366e-04 -1.610187e-04 -1.685296e-04 -1.763837e-04
## ASV4104      3.535456e-04  3.697834e-04  3.867386e-04  4.044405e-04
## ASV8983      2.885218e-06  3.016821e-06  3.154520e-06  3.298640e-06
## ASV2201      1.351473e-04  1.411100e-04  1.473139e-04  1.537669e-04
## ASV3055      9.244486e-05  9.637315e-05  1.004468e-04  1.046693e-04
## ASV0534     -4.607325e-04 -4.817069e-04 -5.035904e-04 -5.264184e-04
## ASV1019      1.550666e-05  1.639052e-05  1.732952e-05  1.832739e-05
## ASV18482    -2.143304e-04 -2.240754e-04 -2.342419e-04 -2.448460e-04
## ASV2694      7.143481e-05  7.447648e-05  7.763117e-05  8.090162e-05
## ASV3412     -6.584816e-05 -6.870079e-05 -7.166335e-05 -7.473878e-05
## ASV4174     -2.143088e-04 -2.240518e-04 -2.342161e-04 -2.448179e-04
## ASV4281     -2.142914e-04 -2.240328e-04 -2.341953e-04 -2.447953e-04
## ASV4949      2.404089e-04  2.511717e-04  2.623849e-04  2.740648e-04
## ASV5881      1.129847e-04  1.180969e-04  1.234277e-04  1.289854e-04
## ASV6299     -9.500936e-05 -9.922966e-05 -1.036232e-04 -1.081957e-04
## ASV0676      2.459997e-04  2.571043e-04  2.686825e-04  2.807521e-04
## ASV1066     -1.677910e-04 -1.753188e-04 -1.831624e-04 -1.913332e-04
## ASV1300     -1.435270e-04 -1.500168e-04 -1.567838e-04 -1.638382e-04
## ASV6455      7.005032e-05  7.327632e-05  7.664580e-05  8.016467e-05
## ASV3455     -2.142863e-04 -2.240272e-04 -2.341892e-04 -2.447886e-04
## ASV6531     -2.142690e-04 -2.240083e-04 -2.341685e-04 -2.447660e-04
## ASV0490      4.283822e-04  4.475938e-04  4.676154e-04  4.884768e-04
## ASV2588      2.343976e-05  2.486813e-05  2.639180e-05  2.801754e-05
## ASV5364      1.349411e-04  1.410454e-04  1.474107e-04  1.540466e-04
## ASV0981     -2.993739e-04 -3.133244e-04 -3.279102e-04 -3.431588e-04
## ASV1563     -6.147401e-05 -6.434499e-05 -6.734762e-05 -7.048776e-05
## ASV0376     -2.872353e-04 -3.006156e-04 -3.146045e-04 -3.292281e-04
## ASV7308     -1.579799e-06 -1.733090e-06 -1.901190e-06 -2.085517e-06
## ASV4817      4.598019e-05  4.790762e-05  4.990311e-05  5.196785e-05
## ASV8716     -3.038543e-04 -3.170108e-04 -3.306796e-04 -3.448757e-04
## ASV1849      3.874649e-04  4.045055e-04  4.222310e-04  4.406631e-04
## ASV9423     -2.996219e-04 -3.132046e-04 -3.273717e-04 -3.421455e-04
## ASV7690      1.130848e-05  1.186557e-05  1.245036e-05  1.306422e-05
## ASV4901      1.655454e-04  1.732227e-04  1.812460e-04  1.896299e-04
## ASV1830     -5.298129e-05 -5.580674e-05 -5.879340e-05 -6.195116e-05
## ASV2316     -2.226306e-04 -2.322981e-04 -2.423461e-04 -2.527863e-04
## ASV0693      3.317602e-04  3.470831e-04  3.630909e-04  3.798120e-04
## ASV1243     -1.822045e-05 -1.883297e-05 -1.945206e-05 -2.007615e-05
## ASV3867      8.738413e-05  9.148927e-05  9.578421e-05  1.002774e-04
## ASV7932      1.880890e-04  1.967610e-04  2.058190e-04  2.152787e-04
## ASV12608     1.361176e-04  1.426324e-04  1.494599e-04  1.566151e-04
## ASV1661      1.969194e-04  2.059168e-04  2.153071e-04  2.251061e-04
## ASV3957      2.071346e-04  2.167475e-04  2.267951e-04  2.372959e-04
## ASV0830     -3.265190e-04 -3.414085e-04 -3.569467e-04 -3.731590e-04
## ASV2078      3.709123e-04  3.879597e-04  4.057626e-04  4.243520e-04
## ASV13932    -2.188716e-04 -2.290446e-04 -2.396786e-04 -2.507935e-04
## ASV5300     -2.188535e-04 -2.290248e-04 -2.396569e-04 -2.507698e-04
## ASV1014     -1.175944e-04 -1.229512e-04 -1.285403e-04 -1.343707e-04
## ASV13059    -6.785500e-05 -7.127168e-05 -7.486667e-05 -7.864966e-05
## ASV4340      4.446510e-05  4.643846e-05  4.849325e-05  5.063232e-05
## ASV5591     -3.641365e-04 -3.807253e-04 -3.980346e-04 -4.160926e-04
## ASV6040     -2.911441e-04 -3.044637e-04 -3.183670e-04 -3.328769e-04
## ASV3904     -1.206413e-04 -1.263171e-04 -1.322562e-04 -1.384704e-04
## ASV2267     -3.404808e-05 -3.562267e-05 -3.726749e-05 -3.898539e-05
## ASV0573     -2.722604e-04 -2.843718e-04 -2.969827e-04 -3.101104e-04
## ASV0851     -2.937525e-04 -3.071909e-04 -3.212177e-04 -3.358561e-04
## ASV7805      9.204629e-05  9.642095e-05  1.010029e-04  1.058017e-04
## ASV3379      3.927708e-04  4.104212e-04  4.288173e-04  4.479866e-04
## ASV0825      1.780715e-04  1.865158e-04  1.953576e-04  2.046152e-04
## ASV2461      2.056079e-04  2.149311e-04  2.246558e-04  2.347972e-04
## ASV2783      2.870449e-04  3.001691e-04  3.138679e-04  3.281640e-04
## ASV0925      3.214162e-04  3.358867e-04  3.509696e-04  3.666874e-04
## ASV7023     -3.065115e-04 -3.207268e-04 -3.355830e-04 -3.511075e-04
## ASV5319      5.573913e-05  5.836327e-05  6.110867e-05  6.398064e-05
## ASV3213      1.913284e-04  2.002179e-04  2.095092e-04  2.192195e-04
## ASV3748     -4.764450e-05 -5.001007e-05 -5.249714e-05 -5.511227e-05
## ASV5491     -6.983584e-05 -7.322653e-05 -7.678463e-05 -8.051862e-05
## ASV7931      1.205063e-04  1.260832e-04  1.319102e-04  1.379976e-04
## ASV12767    -2.198780e-04 -2.301462e-04 -2.408844e-04 -2.521132e-04
## ASV6389      2.215563e-04  2.318710e-04  2.426548e-04  2.539278e-04
## ASV14867    -2.198594e-04 -2.301259e-04 -2.408622e-04 -2.520888e-04
## ASV5105      1.280826e-04  1.341468e-04  1.404957e-04  1.471423e-04
## ASV15927    -2.191257e-04 -2.293211e-04 -2.399794e-04 -2.511205e-04
## ASV2004      7.522092e-05  7.864849e-05  8.222544e-05  8.595771e-05
## ASV5554     -4.361420e-06 -4.982856e-06 -5.670126e-06 -6.429324e-06
## ASV10929    -1.533474e-04 -1.604875e-04 -1.679527e-04 -1.757570e-04
## ASV12778    -7.564865e-05 -7.914771e-05 -8.280386e-05 -8.662373e-05
## ASV14006    -2.190851e-04 -2.292766e-04 -2.399306e-04 -2.510671e-04
## ASV1603      2.142113e-04  2.242145e-04  2.346755e-04  2.456144e-04
## ASV11948     1.102426e-04  1.151331e-04  1.202237e-04  1.255209e-04
## ASV12912    -2.200824e-04 -2.303687e-04 -2.411265e-04 -2.523764e-04
## ASV13147    -2.200642e-04 -2.303487e-04 -2.411045e-04 -2.523523e-04
## ASV14761    -2.200459e-04 -2.303287e-04 -2.410826e-04 -2.523283e-04
## ASV8521      1.760315e-04  1.838732e-04  1.920386e-04  2.005386e-04
## ASV8581     -2.200337e-04 -2.303153e-04 -2.410679e-04 -2.523121e-04
## ASV9875     -3.765349e-05 -3.954552e-05 -4.153660e-05 -4.363223e-05
## ASV9986      1.458564e-04  1.527337e-04  1.599313e-04  1.674640e-04
## ASV2376      2.551825e-04  2.668770e-04  2.790861e-04  2.918303e-04
## ASV17535    -2.200208e-04 -2.303011e-04 -2.410524e-04 -2.522951e-04
## ASV14330    -2.126832e-04 -2.222774e-04 -2.322798e-04 -2.427055e-04
## ASV1333     -4.406027e-04 -4.599409e-04 -4.800538e-04 -5.009661e-04
## ASV2498      1.052601e-04  1.103520e-04  1.156920e-04  1.212921e-04
## ASV6352     -8.682678e-05 -9.064262e-05 -9.461163e-05 -9.873866e-05
## ASV8601     -1.087560e-04 -1.136420e-04 -1.187340e-04 -1.240396e-04
## ASV9776     -8.113297e-05 -8.465122e-05 -8.830590e-05 -9.210082e-05
## ASV1916      1.885619e-04  1.970737e-04  2.059489e-04  2.152012e-04
## ASV1555      2.379120e-05  2.499629e-05  2.626514e-05  2.760132e-05
## ASV2499      2.970704e-04  3.109011e-04  3.253605e-04  3.404757e-04
## ASV0703      2.447608e-04  2.560755e-04  2.678975e-04  2.802479e-04
## ASV2047      3.245928e-04  3.394718e-04  3.550058e-04  3.712214e-04
## ASV5492     -2.207409e-04 -2.310920e-04 -2.419209e-04 -2.532491e-04
## ASV6549     -2.253960e-05 -2.366184e-05 -2.484218e-05 -2.608383e-05
## ASV7757     -7.844590e-05 -8.231964e-05 -8.639024e-05 -9.066814e-05
## ASV0173     -1.871545e-06 -2.047432e-06 -2.239528e-06 -2.449280e-06
## ASV1248     -6.677588e-05 -6.972401e-05 -7.279115e-05 -7.598105e-05
## ASV6502      1.876239e-06  2.052534e-06  2.245070e-06  2.455297e-06
## ASV9844      1.875939e-06  2.052191e-06  2.244677e-06  2.454848e-06
## ASV3903      1.406469e-04  1.472630e-04  1.541861e-04  1.614302e-04
## ASV8199      1.866550e-06  2.041883e-06  2.233361e-06  2.442425e-06
## ASV3309     -9.881329e-06 -1.029513e-05 -1.072323e-05 -1.116579e-05
## ASV5826     -3.239963e-05 -3.399535e-05 -3.567138e-05 -3.743186e-05
## ASV1480     -2.953247e-04 -3.091798e-04 -3.236747e-04 -3.388381e-04
## ASV3090      6.273859e-05  6.558347e-05  6.855070e-05  7.164492e-05
## ASV0758     -1.792458e-04 -1.871145e-04 -1.952986e-04 -2.038079e-04
## ASV0811     -5.406127e-05 -5.644669e-05 -5.892878e-05 -6.151070e-05
## ASV2653      1.463671e-04  1.533097e-04  1.605794e-04  1.681913e-04
## ASV0978      1.513313e-04  1.585263e-04  1.660610e-04  1.739509e-04
## ASV6640     -3.062651e-04 -3.203633e-04 -3.350877e-04 -3.504642e-04
## ASV3423     -1.402374e-05 -1.483806e-05 -1.570487e-05 -1.662792e-05
## ASV0617      3.065795e-04  3.200039e-04  3.339654e-04  3.484811e-04
## ASV14947    -3.095509e-04 -3.239044e-04 -3.389045e-04 -3.545785e-04
## ASV18367    -1.696694e-04 -1.778049e-04 -1.863309e-04 -1.952658e-04
## ASV4574      2.368296e-04  2.472585e-04  2.581071e-04  2.693887e-04
## ASV10514    -1.652537e-04 -1.729978e-04 -1.810983e-04 -1.895708e-04
## ASV11779    -8.268433e-05 -8.695529e-05 -9.145747e-05 -9.620395e-05
## ASV7528     -2.675770e-04 -2.801205e-04 -2.932411e-04 -3.069641e-04
## ASV13153    -1.539330e-04 -1.612049e-04 -1.688166e-04 -1.767836e-04
## ASV7858     -1.366960e-04 -1.431524e-04 -1.499105e-04 -1.569839e-04
## ASV8722      4.668870e-05  4.861050e-05  5.059688e-05  5.264863e-05
## ASV6585     -3.088904e-04 -3.232086e-04 -3.381713e-04 -3.538057e-04
## ASV3311     -2.690664e-04 -2.809747e-04 -2.933676e-04 -3.062608e-04
## ASV2469      4.450082e-06  4.760361e-06  5.093246e-06  5.450342e-06
## ASV11340    -1.336232e-04 -1.395823e-04 -1.457886e-04 -1.522507e-04
## ASV1718      2.525816e-05  2.636001e-05  2.750493e-05  2.869414e-05
## ASV2117     -3.065123e-04 -3.207669e-04 -3.356676e-04 -3.512421e-04
## ASV8252     -2.178154e-04 -2.278891e-04 -2.384147e-04 -2.494113e-04
## ASV8533      4.278595e-05  4.475027e-05  4.680139e-05  4.894285e-05
## ASV9507      3.297324e-05  3.437096e-05  3.581973e-05  3.732064e-05
## ASV0706      1.550014e-04  1.624065e-04  1.701660e-04  1.782969e-04
## ASV10312    -2.177959e-04 -2.278678e-04 -2.383914e-04 -2.493857e-04
## ASV10696    -2.177780e-04 -2.278482e-04 -2.383699e-04 -2.493622e-04
## ASV11203    -2.177601e-04 -2.278286e-04 -2.383484e-04 -2.493387e-04
## ASV12147    -5.216137e-05 -5.468559e-05 -5.733349e-05 -6.011124e-05
## ASV4602     -1.368014e-05 -1.444441e-05 -1.525542e-05 -1.611628e-05
## ASV5568      1.144707e-05  1.204621e-05  1.267849e-05  1.334585e-05
## ASV6777      2.787980e-04  2.917125e-04  3.052082e-04  3.193096e-04
## ASV8749     -2.453856e-04 -2.566094e-04 -2.683250e-04 -2.805521e-04
## ASV4780      4.201906e-05  4.380267e-05  4.565137e-05  4.756651e-05
## ASV10116    -4.126801e-05 -4.315173e-05 -4.511799e-05 -4.717013e-05
## ASV2907      2.375019e-04  2.484429e-04  2.598700e-04  2.718032e-04
## ASV5165      3.091872e-04  3.238914e-04  3.392927e-04  3.554239e-04
## ASV6061      1.726948e-04  1.805469e-04  1.887389e-04  1.972840e-04
## ASV8082     -1.072493e-04 -1.122170e-04 -1.174086e-04 -1.228335e-04
## ASV7696     -1.092262e-04 -1.142927e-04 -1.195882e-04 -1.251223e-04
## ASV0550      2.190446e-05  2.283888e-05  2.380869e-05  2.481490e-05
## ASV7745      1.397721e-04  1.464635e-04  1.534758e-04  1.608245e-04
## ASV3607     -3.061958e-06 -3.159568e-06 -3.257500e-06 -3.355402e-06
## ASV3877     -2.126277e-04 -2.222212e-04 -2.322236e-04 -2.426499e-04
## ASV7667     -9.692659e-05 -1.012405e-04 -1.057329e-04 -1.104103e-04
## ASV9293     -8.117553e-05 -8.498358e-05 -8.896685e-05 -9.313302e-05
## ASV11653    -2.125978e-04 -2.221886e-04 -2.321879e-04 -2.426110e-04
## ASV12850     3.407293e-05  3.583148e-05  3.768436e-05  3.963675e-05
## ASV13104     4.012899e-05  4.181829e-05  4.356779e-05  4.537856e-05
## ASV14208    -2.125845e-04 -2.221741e-04 -2.321721e-04 -2.425938e-04
## ASV1552      1.958015e-04  2.050952e-04  2.148273e-04  2.250182e-04
## ASV2501      1.329448e-04  1.388475e-04  1.449929e-04  1.513893e-04
## ASV2893      2.643546e-04  2.766160e-04  2.894296e-04  3.028187e-04
## ASV3084      1.002327e-04  1.047329e-04  1.094233e-04  1.143108e-04
## ASV3599      1.347227e-04  1.407350e-04  1.469968e-04  1.535168e-04
## ASV3868     -2.125852e-04 -2.221750e-04 -2.321731e-04 -2.425950e-04
## ASV3917     -2.862063e-04 -2.992136e-04 -3.127836e-04 -3.269382e-04
## ASV5695      5.349756e-05  5.609085e-05  5.881112e-05  6.166460e-05
## ASV0131      2.843974e-05  2.947963e-05  3.054157e-05  3.162437e-05
## ASV2847      2.578374e-04  2.693097e-04  2.812555e-04  2.936912e-04
## ASV6875     -2.123868e-04 -2.220704e-04 -2.321754e-04 -2.427184e-04
## ASV1547     -4.388431e-04 -4.586935e-04 -4.793935e-04 -5.009749e-04
## ASV1501     -2.759199e-04 -2.885504e-04 -3.017355e-04 -3.154977e-04
## ASV3876      3.073360e-04  3.214843e-04  3.362608e-04  3.516911e-04
## ASV3456     -3.073108e-04 -3.214568e-04 -3.362307e-04 -3.516581e-04
## ASV1194      2.897865e-04  3.031182e-04  3.170410e-04  3.315790e-04
## ASV2135     -3.710614e-04 -3.883227e-04 -4.063672e-04 -4.252287e-04
## ASV1352      3.072410e-04  3.213804e-04  3.361470e-04  3.515666e-04
## ASV3208      3.494944e-04  3.656004e-04  3.824229e-04  3.999916e-04
## ASV1164      2.816526e-06  3.077843e-06  3.362458e-06  3.672331e-06
## ASV3492      1.462533e-04  1.532737e-04  1.606327e-04  1.683465e-04
## ASV1601      1.690951e-04  1.768691e-04  1.849874e-04  1.934640e-04
## ASV5347     -2.169777e-04 -2.267651e-04 -2.369693e-04 -2.476059e-04
## ASV0293      1.632784e-04  1.708065e-04  1.786697e-04  1.868819e-04
## ASV1509      2.817382e-04  2.946789e-04  3.081909e-04  3.222972e-04
## ASV2801      4.099837e-05  4.283426e-05  4.474735e-05  4.674045e-05
## ASV2873     -6.531694e-05 -6.841826e-05 -7.166645e-05 -7.506843e-05
## ASV2162     -4.396592e-05 -4.594545e-05 -4.800903e-05 -5.015980e-05
## ASV0462      1.706805e-04  1.781254e-04  1.858649e-04  1.939081e-04
## ASV5367     -2.664213e-04 -2.788040e-04 -2.917471e-04 -3.052747e-04
## ASV2715      3.333161e-04  3.485021e-04  3.643479e-04  3.808792e-04
## ASV0371      4.092125e-04  4.274779e-04  4.465053e-04  4.663219e-04
## ASV8090     -2.823505e-04 -2.951448e-04 -3.084885e-04 -3.224026e-04
## ASV6320     -2.201712e-04 -2.304688e-04 -2.412392e-04 -2.525035e-04
## ASV2562      2.312476e-04  2.420903e-04  2.534329e-04  2.652975e-04
## ASV1505     -3.244115e-04 -3.395089e-04 -3.552912e-04 -3.717879e-04
## ASV4924     -2.488926e-04 -2.602586e-04 -2.721206e-04 -2.844980e-04
## ASV1437      2.780934e-04  2.908899e-04  3.042544e-04  3.182100e-04
## ASV3816     -1.859274e-05 -1.922965e-05 -1.987578e-05 -2.052993e-05
## ASV1969     -1.345179e-04 -1.410206e-04 -1.478370e-04 -1.549817e-04
## ASV3146      1.479452e-04  1.545320e-04  1.613910e-04  1.685318e-04
## ASV0321     -1.601262e-04 -1.673358e-04 -1.748520e-04 -1.826862e-04
## ASV1020      3.226165e-04  3.371940e-04  3.523946e-04  3.682417e-04
## ASV4138      2.247501e-05  2.365366e-05  2.489770e-05  2.621096e-05
## ASV0329     -1.784185e-04 -1.866798e-04 -1.953119e-04 -2.043300e-04
## ASV10647     3.204399e-05  3.359811e-05  3.522866e-05  3.693946e-05
## ASV3389      2.658415e-04  2.781051e-04  2.909155e-04  3.042953e-04
## ASV6880      1.433916e-04  1.495397e-04  1.559197e-04  1.625374e-04
## ASV2624     -3.567066e-05 -3.762129e-05 -3.968692e-05 -4.187487e-05
## ASV3686     -5.090753e-05 -5.385689e-05 -5.699237e-05 -6.032652e-05
## ASV12302    -2.215852e-04 -2.320153e-04 -2.429304e-04 -2.543525e-04
## ASV1184      2.715480e-04  2.839643e-04  2.969237e-04  3.104478e-04
## ASV3533     -1.164560e-04 -1.214891e-04 -1.267147e-04 -1.321379e-04
## ASV1735      6.485283e-05  6.763921e-05  7.053076e-05  7.353008e-05
## ASV0483     -1.257499e-04 -1.316715e-04 -1.378680e-04 -1.443516e-04
## ASV0928     -2.500426e-04 -2.616619e-04 -2.738075e-04 -2.865019e-04
## ASV12254    -2.194149e-04 -2.296380e-04 -2.403266e-04 -2.515010e-04
## ASV16025    -2.193967e-04 -2.296180e-04 -2.403048e-04 -2.514771e-04
## ASV3070     -2.193785e-04 -2.295981e-04 -2.402830e-04 -2.514532e-04
## ASV1850      5.154287e-05  5.403056e-05  5.663909e-05  5.937431e-05
## ASV8946     -2.154186e-04 -2.252622e-04 -2.355358e-04 -2.462565e-04
## ASV1536      1.806043e-04  1.888259e-04  1.974037e-04  2.063514e-04
## ASV4151      2.717614e-04  2.840690e-04  2.969049e-04  3.102890e-04
## ASV4585      3.649186e-04  3.814405e-04  3.986707e-04  4.166358e-04
## ASV4921     -8.827068e-05 -9.220630e-05 -9.630396e-05 -1.005690e-04
## ASV6172      2.153703e-04  2.252094e-04  2.354781e-04  2.461934e-04
## ASV6375     -2.153528e-04 -2.251902e-04 -2.354572e-04 -2.461706e-04
## ASV6501      2.450444e-04  2.559407e-04  2.672869e-04  2.790988e-04
## ASV17095    -2.153391e-04 -2.251753e-04 -2.354408e-04 -2.461527e-04
## ASV3679     -2.153216e-04 -2.251561e-04 -2.354199e-04 -2.461298e-04
## ASV5750      2.153041e-04  2.251370e-04  2.353990e-04  2.461069e-04
## ASV5922     -2.152866e-04 -2.251179e-04 -2.353781e-04 -2.460841e-04
## ASV7323     -2.152691e-04 -2.250987e-04 -2.353572e-04 -2.460612e-04
## ASV8515     -3.029757e-06 -3.208246e-06 -3.397529e-06 -3.598210e-06
## ASV8753     -2.152514e-04 -2.250794e-04 -2.353360e-04 -2.460381e-04
## ASV9197      1.479143e-04  1.547068e-04  1.617989e-04  1.692028e-04
## ASV1778      4.020945e-05  4.223005e-05  4.435610e-05  4.659336e-05
## ASV1241      2.777449e-04  2.903168e-04  3.034274e-04  3.170971e-04
## ASV1717      2.170687e-04  2.269942e-04  2.373546e-04  2.481671e-04
## ASV1112      2.492661e-04  2.603317e-04  2.718516e-04  2.838411e-04
## ASV3994      2.922535e-04  3.057686e-04  3.198885e-04  3.346382e-04
## ASV5511     -2.163460e-04 -2.262785e-04 -2.366494e-04 -2.474765e-04
## ASV8706      1.573124e-04  1.647663e-04  1.725708e-04  1.807424e-04
## ASV3049     -2.163318e-04 -2.262629e-04 -2.366323e-04 -2.474578e-04
## ASV4332      1.389872e-04  1.454961e-04  1.523039e-04  1.594237e-04
## ASV7411      2.452459e-04  2.562269e-04  2.676672e-04  2.795832e-04
## ASV7475     -2.163245e-04 -2.262549e-04 -2.366236e-04 -2.474483e-04
## ASV8988     -2.163068e-04 -2.262355e-04 -2.366024e-04 -2.474252e-04
## ASV0688     -4.619038e-04 -4.825900e-04 -5.041425e-04 -5.265922e-04
## ASV1946      1.247107e-04  1.301040e-04  1.357059e-04  1.415221e-04
## ASV3150      3.595062e-04  3.758225e-04  3.928415e-04  4.105900e-04
## ASV3508      1.756596e-04  1.834089e-04  1.914715e-04  1.998574e-04
## ASV3863     -2.162943e-04 -2.262218e-04 -2.365874e-04 -2.474087e-04
## ASV4544      1.699995e-04  1.774897e-04  1.852818e-04  1.933854e-04
## ASV4567      3.902525e-04  4.081109e-04  4.267526e-04  4.462088e-04
## ASV4855     -2.162759e-04 -2.262018e-04 -2.365655e-04 -2.473847e-04
## ASV4872      2.885060e-04  3.015479e-04  3.151465e-04  3.293228e-04
## ASV4881      2.078536e-04  2.176226e-04  2.278440e-04  2.385383e-04
## ASV5283      2.162615e-04  2.261860e-04  2.365482e-04  2.473659e-04
## ASV5302      2.554049e-04  2.670393e-04  2.791813e-04  2.918511e-04
## ASV5909      2.169794e-04  2.268944e-04  2.372425e-04  2.480408e-04
## ASV5933      1.619817e-04  1.694094e-04  1.771640e-04  1.852585e-04
## ASV6019      2.396653e-04  2.502446e-04  2.612532e-04  2.727050e-04
## ASV6043      9.635397e-05  1.009130e-04  1.056859e-04  1.106823e-04
## ASV6908      2.710760e-04  2.834683e-04  2.964027e-04  3.099006e-04
## ASV7245     -2.162711e-04 -2.261965e-04 -2.365597e-04 -2.473784e-04
## ASV7249     -2.162534e-04 -2.261772e-04 -2.365385e-04 -2.473552e-04
## ASV8349      7.288087e-05  7.628194e-05  7.983826e-05  8.355656e-05
## ASV7310     -2.162389e-04 -2.261613e-04 -2.365212e-04 -2.473363e-04
## ASV1893      1.676163e-04  1.752025e-04  1.831148e-04  1.913658e-04
## ASV2354      1.288137e-04  1.344019e-04  1.402082e-04  1.462391e-04
## ASV3435     -3.610447e-05 -3.763596e-05 -3.922346e-05 -4.086818e-05
## ASV0480      3.360087e-04  3.517316e-04  3.681749e-04  3.853700e-04
## ASV0955     -1.167153e-04 -1.221740e-04 -1.278834e-04 -1.338545e-04
## ASV10000     6.560541e-05  6.828848e-05  7.106013e-05  7.392131e-05
## ASV7215     -1.399114e-04 -1.464896e-04 -1.533721e-04 -1.605725e-04
## ASV10423    -3.061192e-04 -3.201521e-04 -3.348024e-04 -3.500949e-04
## ASV6008     -1.635480e-04 -1.710650e-04 -1.789144e-04 -1.871098e-04
## ASV9330     -3.060825e-04 -3.201120e-04 -3.347586e-04 -3.500469e-04
## ASV6051      3.060575e-04  3.200847e-04  3.347287e-04  3.500142e-04
## ASV1675      2.023236e-04  2.115853e-04  2.212532e-04  2.313435e-04
## ASV2043      1.312393e-04  1.374293e-04  1.439081e-04  1.506888e-04
## ASV3634      1.235159e-04  1.294583e-04  1.356888e-04  1.422217e-04
## ASV4077     -3.060455e-04 -3.200716e-04 -3.347144e-04 -3.499986e-04
## ASV4754      1.480862e-04  1.547842e-04  1.617686e-04  1.690504e-04
## ASV6095      3.510822e-04  3.668517e-04  3.832868e-04  4.004118e-04
## ASV6288      2.597196e-04  2.714681e-04  2.837190e-04  2.964910e-04
## ASV6507     -3.060302e-04 -3.200548e-04 -3.346961e-04 -3.499786e-04
## ASV8905      1.554055e-04  1.624326e-04  1.697606e-04  1.774006e-04
## ASV9728     -3.060095e-04 -3.200322e-04 -3.346713e-04 -3.499515e-04
## ASV11144    -3.059845e-04 -3.200049e-04 -3.346415e-04 -3.499189e-04
## ASV1615     -1.231216e-04 -1.288413e-04 -1.348195e-04 -1.410669e-04
## ASV2709     -3.732192e-04 -3.902793e-04 -4.080855e-04 -4.266671e-04
## ASV3003      2.960313e-04  3.097472e-04  3.240809e-04  3.390583e-04
## ASV5163     -2.820220e-04 -2.949297e-04 -3.084033e-04 -3.224652e-04
## ASV6622      1.981629e-04  2.074198e-04  2.171005e-04  2.272235e-04
## ASV1076     -2.921426e-04 -3.055900e-04 -3.196342e-04 -3.342998e-04
## ASV7895      6.917238e-05  7.221503e-05  7.537946e-05  7.866941e-05
## ASV10577    -2.214897e-04 -2.319113e-04 -2.428173e-04 -2.542296e-04
## ASV1272      2.214711e-04  2.318910e-04  2.427950e-04  2.542052e-04
## ASV2492     -1.095601e-04 -1.150851e-04 -1.209004e-04 -1.270222e-04
## ASV5195      2.660050e-04  2.782941e-04  2.911332e-04  3.045453e-04
## ASV5267      1.602000e-04  1.674419e-04  1.749926e-04  1.828637e-04
## ASV6317      2.264629e-04  2.370378e-04  2.480959e-04  2.596584e-04
## ASV2296      8.139850e-05  8.517411e-05  8.912081e-05  9.324603e-05
## ASV2290     -1.996027e-04 -2.085768e-04 -2.179301e-04 -2.276766e-04
## ASV3726      1.734843e-04  1.816807e-04  1.902607e-04  1.992417e-04
## ASV1169      1.467445e-04  1.534301e-04  1.604064e-04  1.676847e-04
## ASV0189     -1.405326e-04 -1.471923e-04 -1.541654e-04 -1.614665e-04
## ASV2729      5.319466e-04  5.568986e-04  5.830006e-04  6.103035e-04
## ASV3469      1.209760e-04  1.265955e-04  1.324694e-04  1.386085e-04
## ASV0762     -2.882260e-04 -3.011838e-04 -3.146886e-04 -3.287601e-04
## ASV9001     -2.666337e-04 -2.782655e-04 -2.903593e-04 -3.029297e-04
## ASV14604    -2.146222e-04 -2.243931e-04 -2.345877e-04 -2.452224e-04
## ASV7439      6.354142e-05  6.665689e-05  6.992867e-05  7.336486e-05
## ASV8625     -2.146078e-04 -2.243774e-04 -2.345706e-04 -2.452037e-04
## ASV11553     4.213573e-05  4.423132e-05  4.643465e-05  4.875152e-05
## ASV14440     5.436836e-06  5.345510e-06  5.219814e-06  5.055756e-06
## ASV16106    -2.145926e-04 -2.243608e-04 -2.345524e-04 -2.451838e-04
## ASV16110    -2.145752e-04 -2.243418e-04 -2.345316e-04 -2.451611e-04
## ASV2229      3.786603e-04  3.956060e-04  4.132606e-04  4.316492e-04
## ASV3854     -2.076622e-04 -2.171184e-04 -2.269848e-04 -2.372773e-04
## ASV5512     -2.145519e-04 -2.243162e-04 -2.345037e-04 -2.451305e-04
## ASV5939      2.881621e-04  3.013840e-04  3.151888e-04  3.295999e-04
## ASV6676     -1.483068e-04 -1.550614e-04 -1.621091e-04 -1.694612e-04
## ASV8381     -2.145127e-04 -2.242734e-04 -2.344568e-04 -2.450794e-04
## ASV2735      2.730752e-04  2.856658e-04  2.988167e-04  3.125508e-04
## ASV9816     -2.145010e-04 -2.242606e-04 -2.344429e-04 -2.450642e-04
## ASV1382      9.649822e-05  1.007420e-04  1.051567e-04  1.097478e-04
## ASV1408     -2.152873e-04 -2.251248e-04 -2.353926e-04 -2.461080e-04
## ASV4902      1.368931e-04  1.435233e-04  1.504786e-04  1.577752e-04
## ASV5600      1.664685e-04  1.740514e-04  1.819639e-04  1.902190e-04
## ASV0815     -4.654674e-05 -4.856547e-05 -5.066247e-05 -5.283992e-05
## ASV11867    -2.152784e-04 -2.251151e-04 -2.353821e-04 -2.460965e-04
## ASV16064    -2.152609e-04 -2.250960e-04 -2.353612e-04 -2.460736e-04
## ASV2250      2.704582e-04  2.829536e-04  2.960084e-04  3.096458e-04
## ASV2417      6.336086e-05  6.644068e-05  6.967215e-05  7.306284e-05
## ASV2807      3.513081e-04  3.669761e-04  3.832951e-04  4.002880e-04
## ASV3224     -2.152207e-04 -2.250520e-04 -2.353132e-04 -2.460213e-04
## ASV4115     -2.152032e-04 -2.250329e-04 -2.352923e-04 -2.459984e-04
## ASV4876      3.523454e-05  3.680328e-05  3.843616e-05  4.013520e-05
## ASV5291      2.094771e-04  2.189021e-04  2.287253e-04  2.389612e-04
## ASV5834      1.016242e-04  1.062727e-04  1.111245e-04  1.161876e-04
## ASV6896      2.363203e-05  2.462046e-05  2.564340e-05  2.670138e-05
## ASV7292     -2.151923e-04 -2.250209e-04 -2.352792e-04 -2.459841e-04
## ASV7924      1.237640e-04  1.295201e-04  1.355370e-04  1.418261e-04
## ASV0710      2.846017e-04  2.974813e-04  3.109120e-04  3.249144e-04
## ASV1925      2.477007e-04  2.588165e-04  2.703996e-04  2.824668e-04
## ASV4247     -2.151732e-04 -2.250002e-04 -2.352565e-04 -2.459593e-04
## ASV4549     -2.151557e-04 -2.249810e-04 -2.352356e-04 -2.459364e-04
## ASV4076      1.800996e-04  1.883409e-04  1.969442e-04  2.059239e-04
## ASV7063      1.749943e-04  1.830869e-04  1.915415e-04  2.003730e-04
## ASV1487      1.855140e-04  1.937493e-04  2.023227e-04  2.112457e-04
## ASV1405      7.709101e-05  8.078369e-05  8.465355e-05  8.870905e-05
## ASV3851      1.911600e-04  2.001324e-04  2.095183e-04  2.193360e-04
## ASV0896      5.830647e-05  6.100920e-05  6.383380e-05  6.678546e-05
## ASV5581      2.781426e-04  2.912655e-04  3.050011e-04  3.193775e-04
## ASV7053     -9.158270e-05 -9.579296e-05 -1.001898e-04 -1.047807e-04
## ASV7171     -2.198515e-04 -2.301175e-04 -2.408533e-04 -2.520796e-04
## ASV4017     -3.009519e-04 -3.149388e-04 -3.295594e-04 -3.448410e-04
## ASV5846      1.853635e-05  1.892617e-05  1.929185e-05  1.962881e-05
## ASV0203      1.870791e-06  1.812521e-06  1.741171e-06  1.655620e-06
## ASV13271     3.406787e-05  3.546091e-05  3.690003e-05  3.838571e-05
## ASV9487      1.375324e-04  1.433203e-04  1.493175e-04  1.555285e-04
## ASV2056     -3.083129e-04 -3.225771e-04 -3.374813e-04 -3.530522e-04
## ASV16933    -3.034104e-04 -3.172016e-04 -3.315897e-04 -3.465977e-04
## ASV0360      1.317491e-04  1.375842e-04  1.436585e-04  1.499802e-04
## ASV1798     -1.973238e-04 -2.062861e-04 -2.156355e-04 -2.253867e-04
## ASV17286    -2.196155e-04 -2.298569e-04 -2.405655e-04 -2.517616e-04
## ASV8175     -2.195973e-04 -2.298370e-04 -2.405437e-04 -2.517377e-04
## ASV6679      2.324195e-04  2.429851e-04  2.540073e-04  2.655036e-04
## ASV6776      1.121038e-04  1.170892e-04  1.222798e-04  1.276825e-04
## ASV9062     -2.195807e-04 -2.298189e-04 -2.405238e-04 -2.517160e-04
## ASV9564     -1.948819e-05 -2.050722e-05 -2.158318e-05 -2.271953e-05
## ASV6431     -2.195612e-04 -2.297974e-04 -2.405003e-04 -2.516902e-04
## ASV9940      8.953010e-05  9.360229e-05  9.785030e-05  1.022808e-04
## ASV7001     -3.038506e-04 -3.176744e-04 -3.320969e-04 -3.471412e-04
## ASV3044      3.431141e-04  3.587228e-04  3.750080e-04  3.919963e-04
## ASV6684      1.269279e-04  1.330349e-04  1.394376e-04  1.461504e-04
## ASV12278     2.020225e-06  2.206052e-06  2.408435e-06  2.628775e-06
## ASV3543     -2.029955e-04 -2.119291e-04 -2.212237e-04 -2.308910e-04
## ASV6397      2.016583e-06  2.202065e-06  2.404071e-06  2.623999e-06
## ASV9939      2.016266e-06  2.201703e-06  2.403658e-06  2.623528e-06
## ASV9432      1.773326e-04  1.857141e-04  1.944881e-04  2.036724e-04
## ASV2630     -2.205144e-04 -2.308506e-04 -2.416629e-04 -2.529724e-04
## ASV2175      2.894555e-04  3.030411e-04  3.172547e-04  3.321245e-04
## ASV4107      2.386574e-04  2.497489e-04  2.613426e-04  2.734598e-04
## ASV9172     -3.042577e-05 -3.200334e-05 -3.366776e-05 -3.542421e-05
## ASV3141      2.840726e-04  2.974792e-04  3.115122e-04  3.262003e-04
## ASV9010     -2.201479e-04 -2.304406e-04 -2.412054e-04 -2.524631e-04
## ASV2550      2.180251e-04  2.280265e-04  2.384686e-04  2.493691e-04
## ASV5845     -2.201354e-04 -2.304269e-04 -2.411903e-04 -2.524465e-04
## ASV3998      2.201171e-04  2.304068e-04  2.411684e-04  2.524225e-04
## ASV1389     -2.373311e-04 -2.476475e-04 -2.583698e-04 -2.695105e-04
## ASV0615     -2.484669e-04 -2.598675e-04 -2.717713e-04 -2.841988e-04
## ASV9127     -3.045625e-04 -3.184917e-04 -3.330310e-04 -3.482047e-04
## ASV1190      4.329422e-04  4.523464e-04  4.725647e-04  4.936264e-04
## ASV1211      1.091160e-04  1.141086e-04  1.193210e-04  1.247621e-04
## ASV1766     -3.131966e-04 -3.276179e-04 -3.426796e-04 -3.584079e-04
## ASV2337      2.180333e-04  2.281206e-04  2.386601e-04  2.496707e-04
## ASV2463      4.694385e-05  4.911359e-05  5.138028e-05  5.374792e-05
## ASV2806      1.626634e-04  1.699351e-04  1.775120e-04  1.854052e-04
## ASV0439     -2.807955e-04 -2.937222e-04 -3.072224e-04 -3.213196e-04
## ASV0839      2.675680e-04  2.801947e-04  2.934101e-04  3.072408e-04
## ASV14975    -2.180016e-04 -2.280858e-04 -2.386220e-04 -2.496290e-04
## ASV17712    -2.179836e-04 -2.280662e-04 -2.386005e-04 -2.496055e-04
## ASV2010     -2.480247e-05 -2.589144e-05 -2.702342e-05 -2.819964e-05
## ASV2041      1.142353e-04  1.197560e-04  1.255455e-04  1.316170e-04
## ASV2124     -2.812440e-04 -2.942906e-04 -3.079256e-04 -3.221737e-04
## ASV2585      3.891746e-04  4.070408e-04  4.256951e-04  4.451696e-04
## ASV3314      3.080873e-04  3.224654e-04  3.375002e-04  3.532206e-04
## ASV5051     -2.837866e-05 -2.952206e-05 -3.070038e-05 -3.191350e-05
## ASV10784     1.093667e-04  1.143452e-04  1.195397e-04  1.249587e-04
## ASV3279     -2.179403e-04 -2.280187e-04 -2.385486e-04 -2.495487e-04
## ASV9498      1.512735e-05  1.569238e-05  1.627064e-05  1.686162e-05
## ASV1059     -2.325915e-04 -2.435014e-04 -2.549149e-04 -2.668545e-04
## ASV13008    -2.179219e-04 -2.279986e-04 -2.385265e-04 -2.495245e-04
## ASV15803    -2.179039e-04 -2.279789e-04 -2.385050e-04 -2.495010e-04
## ASV2559     -2.114945e-04 -2.212817e-04 -2.315082e-04 -2.421923e-04
## ASV2623     -2.178865e-04 -2.279598e-04 -2.384841e-04 -2.494781e-04
## ASV2802     -1.224668e-04 -1.280608e-04 -1.338991e-04 -1.399916e-04
## ASV3799      3.346632e-04  3.499627e-04  3.659319e-04  3.825976e-04
## ASV5274     -3.861119e-07 -5.197016e-07 -6.697946e-07 -8.380166e-07
## ASV5835      1.344055e-04  1.407495e-04  1.473905e-04  1.543423e-04
## ASV7251     -2.178824e-04 -2.279553e-04 -2.384792e-04 -2.494727e-04
## ASV7616     -2.178645e-04 -2.279357e-04 -2.384577e-04 -2.494492e-04
## ASV9576     -2.178465e-04 -2.279161e-04 -2.384362e-04 -2.494257e-04
## ASV2870      1.596508e-04  1.670462e-04  1.747738e-04  1.828476e-04
## ASV3668     -1.403372e-04 -1.469044e-04 -1.537727e-04 -1.609554e-04
## ASV1633      1.061562e-04  1.111720e-04  1.164225e-04  1.219184e-04
## ASV6060     -4.242554e-06 -4.802858e-06 -5.420161e-06 -6.099509e-06
## ASV6305      1.097325e-04  1.148994e-04  1.203064e-04  1.259644e-04
## ASV5164      7.122610e-05  7.432736e-05  7.754981e-05  8.089688e-05
## ASV7252     -2.183428e-04 -2.284635e-04 -2.390401e-04 -2.500919e-04
## ASV9343      1.882788e-04  1.972543e-04  2.066574e-04  2.165084e-04
## ASV6835     -3.650751e-05 -3.814515e-05 -3.985153e-05 -4.162908e-05
## ASV1264      2.658255e-04  2.780000e-04  2.907101e-04  3.039772e-04
## ASV0591      2.337366e-05  2.411149e-05  2.485172e-05  2.559179e-05
## ASV1351      3.070664e-04  3.213135e-04  3.362034e-04  3.517637e-04
## ASV14224    -2.182984e-04 -2.284149e-04 -2.389869e-04 -2.500337e-04
## ASV1432     -2.182804e-04 -2.283952e-04 -2.389654e-04 -2.500101e-04
## ASV1559     -1.829324e-04 -1.914743e-04 -2.004066e-04 -2.097464e-04
## ASV2182      3.390168e-04  3.545321e-04  3.707281e-04  3.876318e-04
## ASV2304     -1.818293e-05 -1.896542e-05 -1.977759e-05 -2.062017e-05
## ASV6838     -1.874373e-06 -1.943827e-06 -2.014863e-06 -2.087417e-06
## ASV1125     -3.272394e-05 -3.431070e-05 -3.597539e-05 -3.772191e-05
## ASV17948    -2.182739e-04 -2.283880e-04 -2.389575e-04 -2.500015e-04
## ASV2609      1.925371e-04  2.015487e-04  2.109743e-04  2.208322e-04
## ASV6128     -1.790450e-04 -1.873894e-04 -1.961100e-04 -2.052221e-04
## ASV1338      4.307877e-05  4.476483e-05  4.649873e-05  4.828003e-05
## ASV2136      7.923055e-05  8.268808e-05  8.628219e-05  9.001703e-05
## ASV0929     -1.992268e-04 -2.083065e-04 -2.177815e-04 -2.276673e-04
## ASV3479      1.374176e-04  1.435905e-04  1.500232e-04  1.567250e-04
## ASV0886      3.667310e-04  3.836225e-04  4.012646e-04  4.196881e-04
## ASV1652      1.683834e-04  1.762041e-04  1.843787e-04  1.929226e-04
## ASV1160      3.043260e-04  3.184318e-04  3.331730e-04  3.485764e-04
## ASV5260     -5.755526e-05 -6.043503e-05 -6.346356e-05 -6.664881e-05
## ASV2352      3.732904e-04  3.899370e-04  4.072755e-04  4.253304e-04
## ASV0986     -1.480595e-04 -1.547455e-04 -1.617169e-04 -1.689844e-04
## ASV2021      2.456261e-04  2.568582e-04  2.685823e-04  2.808180e-04
## ASV16599    -2.014503e-04 -2.112867e-04 -2.216090e-04 -2.324412e-04
## ASV3497      1.867079e-04  1.954139e-04  2.045174e-04  2.140358e-04
## ASV1305      1.256721e-04  1.317357e-04  1.380927e-04  1.447569e-04
## ASV0927     -2.863010e-04 -2.986450e-04 -3.114620e-04 -3.247652e-04
## ASV0647     -9.417666e-05 -9.810533e-05 -1.021715e-04 -1.063775e-04
## ASV1832     -1.220917e-04 -1.276389e-04 -1.334260e-04 -1.394623e-04
## ASV1277      1.454371e-04  1.520976e-04  1.590507e-04  1.663078e-04
## ASV22332    -2.187946e-04 -2.289576e-04 -2.395805e-04 -2.506828e-04
## ASV10080    -2.759264e-05 -2.932664e-05 -3.117883e-05 -3.315757e-05
## ASV14157     2.941869e-05  3.086035e-05  3.237419e-05  3.396394e-05
## ASV15829    -2.187759e-04 -2.289371e-04 -2.395580e-04 -2.506581e-04
## ASV3609     -2.187578e-04 -2.289173e-04 -2.395363e-04 -2.506343e-04
## ASV5737      4.862428e-05  5.069145e-05  5.283440e-05  5.505473e-05
## ASV1474      1.595729e-04  1.670278e-04  1.748230e-04  1.829734e-04
## ASV2028      2.177712e-04  2.271623e-04  2.369136e-04  2.470349e-04
## ASV0818      2.629295e-04  2.750375e-04  2.876831e-04  3.008884e-04
## ASV0505     -2.275919e-04 -2.382151e-04 -2.493225e-04 -2.609350e-04
## ASV1813      1.072531e-04  1.119624e-04  1.168599e-04  1.219515e-04
## ASV0512      2.364287e-04  2.476362e-04  2.593678e-04  2.716470e-04
## ASV5374     -1.673890e-04 -1.751582e-04 -1.832791e-04 -1.917670e-04
## ASV2927     -2.137604e-05 -2.197142e-05 -2.255701e-05 -2.312906e-05
## ASV3596      1.641129e-04  1.714125e-04  1.790128e-04  1.869240e-04
## ASV1137      9.795614e-05  1.022386e-04  1.066897e-04  1.113144e-04
## ASV4541      2.491424e-06  2.722248e-06  2.973869e-06  3.248077e-06
## ASV9872     -2.491030e-06 -2.721798e-06 -2.973355e-06 -3.247491e-06
## ASV0359     -7.685836e-05 -8.025237e-05 -8.378382e-05 -8.745713e-05
## ASV0720     -1.312428e-04 -1.371071e-04 -1.432150e-04 -1.495752e-04
## ASV10545    -2.501567e-06 -2.733273e-06 -2.985846e-06 -3.261082e-06
## ASV13384    -2.501172e-06 -2.732821e-06 -2.985330e-06 -3.260493e-06
## ASV1456      5.722253e-06  5.964343e-06  6.215310e-06  6.475361e-06
## ASV1751     -2.501050e-06 -2.732667e-06 -2.985138e-06 -3.260255e-06
## ASV18419    -2.500655e-06 -2.732216e-06 -2.984622e-06 -3.259667e-06
## ASV2970      2.500260e-06  2.731764e-06  2.984107e-06  3.259078e-06
## ASV4215      1.707680e-04  1.786233e-04  1.868264e-04  1.953916e-04
## ASV4742      2.838079e-05  2.950378e-05  3.066007e-05  3.184958e-05
## ASV5017      5.383657e-05  5.621939e-05  5.869929e-05  6.127948e-05
## ASV5139     -2.497359e-06 -2.728528e-06 -2.980495e-06 -3.255047e-06
## ASV9133     -2.496965e-06 -2.728078e-06 -2.979980e-06 -3.254459e-06
## ASV9447     -2.496570e-06 -2.727627e-06 -2.979466e-06 -3.253872e-06
## ASV0842     -1.621757e-04 -1.691868e-04 -1.764693e-04 -1.840311e-04
## ASV12293     1.136274e-04  1.184250e-04  1.233973e-04  1.285482e-04
## ASV1965      2.053506e-04  2.149213e-04  2.249283e-04  2.353904e-04
## ASV2005      2.243758e-04  2.340999e-04  2.442016e-04  2.546918e-04
## ASV5335      1.670261e-04  1.743746e-04  1.820184e-04  1.899668e-04
## ASV6438     -2.522504e-06 -2.755874e-06 -3.010222e-06 -3.287348e-06
## ASV7798     -2.522106e-06 -2.755419e-06 -3.009702e-06 -3.286755e-06
## ASV2691     -2.311759e-04 -2.419086e-04 -2.531257e-04 -2.648478e-04
## ASV9958      1.890201e-04  1.975922e-04  2.065329e-04  2.158565e-04
## ASV1512      6.866250e-05  7.194275e-05  7.538027e-05  7.898267e-05
## ASV1226      3.104388e-04  3.246570e-04  3.395005e-04  3.549946e-04
## ASV2130     -5.476751e-04 -5.727315e-04 -5.988865e-04 -6.261838e-04
## ASV0874     -1.704468e-04 -1.782046e-04 -1.863006e-04 -1.947482e-04
## ASV5436     -2.437531e-04 -2.550209e-04 -2.667929e-04 -2.790900e-04
## ASV0383     -2.687252e-04 -2.805007e-04 -2.927453e-04 -3.054738e-04
## ASV1882      2.628096e-04  2.743416e-04  2.863364e-04  2.988090e-04
## ASV2471     -1.484745e-04 -1.552566e-04 -1.623351e-04 -1.697219e-04
## ASV4049     -2.109240e-04 -2.205115e-04 -2.305135e-04 -2.409458e-04
## ASV3014     -1.181075e-04 -1.233433e-04 -1.287933e-04 -1.344648e-04
## ASV0316     -4.226124e-04 -4.419611e-04 -4.621594e-04 -4.832412e-04
## ASV1621     -2.931967e-04 -3.064334e-04 -3.202345e-04 -3.346212e-04
## ASV13266    -2.152050e-04 -2.250324e-04 -2.352889e-04 -2.459915e-04
## ASV1635     -2.133967e-04 -2.231386e-04 -2.333057e-04 -2.439146e-04
## ASV2042      1.567492e-04  1.639156e-04  1.713960e-04  1.792027e-04
## ASV2317     -2.557863e-04 -2.674248e-04 -2.795676e-04 -2.922343e-04
## ASV3697      1.933247e-04  2.020078e-04  2.110570e-04  2.204858e-04
## ASV6404      3.557320e-04  3.716276e-04  3.881872e-04  4.054344e-04
## ASV15616     1.471149e-05  1.554546e-05  1.643093e-05  1.737135e-05
## ASV10783    -2.151676e-04 -2.249915e-04 -2.352442e-04 -2.459426e-04
## ASV6912     -1.614545e-04 -1.687783e-04 -1.764171e-04 -1.843832e-04
## ASV1561      4.364048e-04  4.560003e-04  4.764220e-04  4.976999e-04
## ASV4404      2.974455e-04  3.109944e-04  3.251319e-04  3.398811e-04
## ASV1110      2.184453e-04  2.283126e-04  2.386008e-04  2.493255e-04
## ASV2844     -7.392366e-05 -7.746319e-05 -8.117248e-05 -8.505965e-05
## ASV5224      2.180135e-04  2.279386e-04  2.382938e-04  2.490957e-04
## ASV6300     -2.185094e-04 -2.286450e-04 -2.392377e-04 -2.503069e-04
## ASV8078     -2.184914e-04 -2.286252e-04 -2.392160e-04 -2.502832e-04
## ASV9722      1.015510e-06  8.513735e-07  6.604026e-07  4.397029e-07
## ASV6911     -2.184732e-04 -2.286053e-04 -2.391942e-04 -2.502592e-04
## ASV5474     -4.471748e-05 -4.687674e-05 -4.914118e-05 -5.151595e-05
## ASV2761     -5.123231e-04 -5.356537e-04 -5.599972e-04 -5.853929e-04
## ASV5943     -1.423322e-04 -1.491705e-04 -1.563394e-04 -1.638552e-04
## ASV0600     -3.729299e-05 -3.863422e-05 -4.000127e-05 -4.139225e-05
## ASV0608     -4.596956e-04 -4.805294e-04 -5.022594e-04 -5.249199e-04
## ASV1586      1.107765e-04  1.156770e-04  1.207779e-04  1.260860e-04
## ASV0206     -5.107018e-04 -5.334371e-04 -5.571121e-04 -5.817589e-04
## ASV4042     -2.338344e-04 -2.445300e-04 -2.556942e-04 -2.673457e-04
## ASV5304     -6.956317e-06 -7.333134e-06 -7.731340e-06 -8.152156e-06
## ASV0949     -8.113769e-05 -8.534301e-05 -8.977759e-05 -9.445458e-05
## ASV1856      2.693416e-04  2.816855e-04  2.945722e-04  3.080233e-04
## ASV2584      3.183467e-05  3.317314e-05  3.455842e-05  3.599114e-05
## ASV2287     -1.329848e-05 -1.427720e-05 -1.533065e-05 -1.646441e-05
## ASV2364     -3.822223e-04 -3.996122e-04 -4.177560e-04 -4.366831e-04
## ASV11481    -3.045333e-04 -3.188037e-04 -3.337312e-04 -3.493449e-04
## ASV2906     -1.059508e-04 -1.109428e-04 -1.161668e-04 -1.216333e-04
## ASV0161     -1.267269e-04 -1.324835e-04 -1.384884e-04 -1.447511e-04
## ASV0062     -8.328797e-04 -8.707823e-04 -9.103279e-04 -9.515801e-04
## ASV3811     -1.969001e-04 -2.052718e-04 -2.139562e-04 -2.229616e-04
## ASV0225      3.295846e-05  3.414475e-05  3.535521e-05  3.658853e-05
## ASV4672     -2.670309e-04 -2.790297e-04 -2.915350e-04 -3.045655e-04
## ASV1607     -2.032511e-05 -2.129849e-05 -2.231709e-05 -2.338276e-05
## ASV3060      5.275905e-05  5.530193e-05  5.796848e-05  6.076477e-05
## ASV2275     -3.811152e-05 -3.985348e-05 -4.167156e-05 -4.356873e-05
## ASV5375      1.491433e-04  1.561714e-04  1.635268e-04  1.712244e-04
## ASV0352     -4.458897e-04 -4.666092e-04 -4.882668e-04 -5.109025e-04
## ASV1107      1.284986e-04  1.346258e-04  1.410429e-04  1.477633e-04
## ASV4887      1.160149e-04  1.210480e-04  1.262766e-04  1.317062e-04
## ASV2397     -5.852251e-05 -6.093993e-05 -6.343947e-05 -6.602225e-05
## ASV7541     -1.399072e-04 -1.462362e-04 -1.528357e-04 -1.597159e-04
## ASV7387     -3.059791e-04 -3.200121e-04 -3.346628e-04 -3.499560e-04
## ASV1355      2.805798e-04  2.935556e-04  3.071138e-04  3.212789e-04
## ASV1764     -1.463750e-04 -1.530030e-04 -1.599156e-04 -1.671236e-04
## ASV1960     -2.694491e-04 -2.810067e-04 -2.930044e-04 -3.054541e-04
## ASV0484     -5.172640e-05 -5.409339e-05 -5.656442e-05 -5.914368e-05
## ASV2487      8.370591e-05  8.717208e-05  9.075751e-05  9.446409e-05
## ASV0422      2.618547e-04  2.732450e-04  2.850843e-04  2.973864e-04
## ASV0081     -1.637787e-04 -1.715348e-04 -1.796557e-04 -1.881583e-04
## ASV1341     -1.413523e-04 -1.475339e-04 -1.539606e-04 -1.606400e-04
## ASV1001     -3.345058e-04 -3.492267e-04 -3.645402e-04 -3.804652e-04
## ASV0317     -8.091936e-05 -8.484415e-05 -8.895954e-05 -9.327457e-05
## ASV2728     -2.322615e-04 -2.428819e-04 -2.539676e-04 -2.655374e-04
## ASV0884     -2.979099e-04 -3.121335e-04 -3.270351e-04 -3.426469e-04
## ASV0464      6.378469e-05  6.721782e-05  7.084906e-05  7.469066e-05
## ASV2963      2.033931e-04  2.125073e-04  2.220048e-04  2.318994e-04
## ASV4608      9.187654e-05  9.607203e-05  1.004505e-04  1.050190e-04
## ASV3534      2.280629e-04  2.379087e-04  2.481331e-04  2.587465e-04
## ASV0291     -1.963962e-04 -2.052262e-04 -2.144288e-04 -2.240175e-04
## ASV0635     -2.833483e-04 -2.965828e-04 -3.104230e-04 -3.248955e-04
## ASV0867      2.281087e-04  2.389338e-04  2.502698e-04  2.621408e-04
## ASV1206     -2.647460e-05 -2.756754e-05 -2.869728e-05 -2.986425e-05
## ASV1230     -1.652324e-06 -1.808350e-06 -1.978836e-06 -2.165083e-06
## ASV1265      6.070155e-05  6.347452e-05  6.636886e-05  6.938943e-05
## ASV1291     -1.874112e-04 -1.961785e-04 -2.053481e-04 -2.149377e-04
## ASV1524      3.866199e-04  4.037853e-04  4.216560e-04  4.402559e-04
## ASV2153     -2.982921e-04 -3.115402e-04 -3.253340e-04 -3.396925e-04
## ASV2714      1.626562e-06  1.780256e-06  1.948209e-06  2.131702e-06
## ASV4246     -1.626300e-06 -1.779957e-06 -1.947866e-06 -2.131309e-06
## ASV0945      1.986507e-04  2.077273e-04  2.172003e-04  2.270853e-04
## ASV2380      4.614023e-04  4.819285e-04  5.033032e-04  5.255556e-04
## ASV0214     -6.920130e-05 -7.180585e-05 -7.447479e-05 -7.720645e-05
## ASV10461    -1.654166e-06 -1.810403e-06 -1.981126e-06 -2.167636e-06
## ASV4177      1.349456e-04  1.407200e-04  1.467115e-04  1.529256e-04
## ASV0237     -3.341642e-04 -3.497075e-04 -3.659555e-04 -3.829385e-04
## ASV11323    -3.774228e-04 -3.948444e-04 -4.130445e-04 -4.320556e-04
## ASV2232     -6.516298e-05 -6.802980e-05 -7.101182e-05 -7.411267e-05
## ASV0115     -1.216454e-04 -1.272114e-04 -1.330209e-04 -1.390834e-04
## ASV1171      5.650526e-05  5.875872e-05  6.108116e-05  6.347272e-05
## ASV1942      2.614545e-04  2.735326e-04  2.861516e-04  2.993341e-04
## ASV1889      2.619466e-05  2.733046e-05  2.851004e-05  2.973458e-05
## ASV0920      5.805068e-05  6.085058e-05  6.378649e-05  6.686501e-05
## ASV1805     -3.351709e-04 -3.504689e-04 -3.664345e-04 -3.830940e-04
## ASV1712      2.007825e-04  2.097931e-04  2.191818e-04  2.289622e-04
## ASV1458      2.949781e-04  3.080727e-04  3.217072e-04  3.359001e-04
## ASV1985      3.134572e-04  3.276648e-04  3.424841e-04  3.579385e-04
## ASV2960     -2.002722e-04 -2.087584e-04 -2.175588e-04 -2.266814e-04
## ASV5207     -6.093747e-05 -6.313201e-05 -6.537223e-05 -6.765590e-05
## ASV8548     -2.002538e-04 -2.087384e-04 -2.175372e-04 -2.266580e-04
## ASV0449     -1.200702e-04 -1.258108e-04 -1.318229e-04 -1.381188e-04
## ASV0609     -2.709821e-04 -2.832046e-04 -2.959462e-04 -3.092258e-04
## ASV1038      1.041186e-04  1.085141e-04  1.130689e-04  1.177865e-04
## ASV1145     -6.278539e-05 -6.535557e-05 -6.801173e-05 -7.075504e-05
## ASV15767    -2.002500e-04 -2.087344e-04 -2.175330e-04 -2.266535e-04
## ASV1630      2.824176e-04  2.948103e-04  3.077013e-04  3.211072e-04
## ASV1911      3.521629e-04  3.683250e-04  3.852004e-04  4.028181e-04
## ASV1950      2.546571e-04  2.657085e-04  2.771936e-04  2.891257e-04
## ASV2583      2.001975e-04  2.086773e-04  2.174709e-04  2.265860e-04
## ASV2853     -2.938241e-04 -3.068009e-04 -3.203066e-04 -3.343591e-04
## ASV2948      2.001662e-04  2.086432e-04  2.174338e-04  2.265457e-04
## ASV3116     -3.203038e-04 -3.342644e-04 -3.487773e-04 -3.638595e-04
## ASV3160     -1.721344e-04 -1.793088e-04 -1.867377e-04 -1.944265e-04
## ASV3354      2.117336e-04  2.214887e-04  2.316762e-04  2.423134e-04
## ASV3368      2.001230e-04  2.085963e-04  2.173829e-04  2.264905e-04
## ASV3464     -2.001079e-04 -2.085800e-04 -2.173652e-04 -2.264713e-04
## ASV3577      2.000929e-04  2.085637e-04  2.173475e-04  2.264521e-04
## ASV3746      2.618458e-04  2.731923e-04  2.849809e-04  2.972243e-04
## ASV3942      8.648225e-05  9.083721e-05  9.541863e-05  1.002386e-04
## ASV4000      2.000680e-04  2.085366e-04  2.173181e-04  2.264203e-04
## ASV4207      3.579170e-04  3.746604e-04  3.921716e-04  4.104844e-04
## ASV4261      2.000549e-04  2.085224e-04  2.173028e-04  2.264037e-04
## ASV4466      7.308501e-05  7.700582e-05  8.114786e-05  8.552393e-05
## ASV4487     -2.000448e-04 -2.085115e-04 -2.172910e-04 -2.263910e-04
## ASV4572     -1.514157e-04 -1.579625e-04 -1.647646e-04 -1.718295e-04
## ASV4718      2.000199e-04  2.084845e-04  2.172616e-04  2.263591e-04
## ASV4757     -2.000048e-04 -2.084682e-04 -2.172439e-04 -2.263399e-04
## ASV4929     -1.999898e-04 -2.084518e-04 -2.172262e-04 -2.263208e-04
## ASV5611     -1.999748e-04 -2.084355e-04 -2.172085e-04 -2.263016e-04
## ASV5614     -1.999598e-04 -2.084192e-04 -2.171909e-04 -2.262824e-04
## ASV5898      1.732545e-04  1.809760e-04  1.890172e-04  1.973891e-04
## ASV7627     -4.356172e-05 -4.498595e-05 -4.642429e-05 -4.787347e-05
## ASV3105     -1.099555e-04 -1.144484e-04 -1.190931e-04 -1.238922e-04
## ASV4762     -2.938815e-04 -3.068702e-04 -3.203893e-04 -3.344568e-04
## ASV5622      1.999216e-04  2.083778e-04  2.171459e-04  2.262337e-04
## ASV7129      2.601626e-04  2.718741e-04  2.840824e-04  2.968057e-04
## ASV12138    -1.999011e-04 -2.083555e-04 -2.171217e-04 -2.262074e-04
## ASV1687     -2.982200e-04 -3.116393e-04 -3.256298e-04 -3.402132e-04
## ASV2187      1.483578e-04  1.545662e-04  1.609977e-04  1.676573e-04
## ASV2204      3.019566e-04  3.154713e-04  3.295509e-04  3.442155e-04
## ASV2914      2.338801e-04  2.439220e-04  2.543482e-04  2.651693e-04
## ASV3297     -1.998466e-04 -2.082962e-04 -2.170573e-04 -2.261374e-04
## ASV3310     -2.566417e-04 -2.677659e-04 -2.793253e-04 -2.913329e-04
## ASV3677      1.504764e-05  1.632678e-05  1.771226e-05  1.921234e-05
## ASV4508      1.998143e-04  2.082613e-04  2.170194e-04  2.260963e-04
## ASV6236     -9.720674e-05 -1.009583e-04 -1.048152e-04 -1.087768e-04
## ASV6285      1.997932e-04  2.082383e-04  2.169946e-04  2.260695e-04
## ASV7576     -1.997782e-04 -2.082221e-04 -2.169769e-04 -2.260503e-04
## ASV7917     -1.997632e-04 -2.082058e-04 -2.169593e-04 -2.260312e-04
## ASV9353     -1.997482e-04 -2.081896e-04 -2.169416e-04 -2.260121e-04
## ASV1656      3.310690e-04  3.457951e-04  3.611298e-04  3.770942e-04
## ASV0280     -3.145760e-04 -3.292991e-04 -3.446987e-04 -3.608048e-04
## ASV4747      5.383847e-06  5.897856e-06  6.459893e-06  7.074312e-06
## ASV2108     -3.858263e-04 -4.037599e-04 -4.225066e-04 -4.421015e-04
## ASV0885      1.293817e-04  1.353426e-04  1.415689e-04  1.480715e-04
## ASV2538     -1.051119e-04 -1.097742e-04 -1.146274e-04 -1.196779e-04
## ASV0968      2.383856e-04  2.492193e-04  2.605210e-04  2.723089e-04
## ASV1229     -2.141683e-04 -2.238943e-04 -2.340396e-04 -2.446201e-04
## ASV13306    -2.141510e-04 -2.238754e-04 -2.340189e-04 -2.445975e-04
## ASV13952     1.309652e-04  1.366343e-04  1.425231e-04  1.486379e-04
## ASV14631     1.188727e-04  1.247064e-04  1.308336e-04  1.372695e-04
## ASV2119      2.533456e-04  2.643056e-04  2.756895e-04  2.875093e-04
## ASV2450      2.230655e-04  2.333469e-04  2.440865e-04  2.553031e-04
## ASV2656     -2.141441e-04 -2.238680e-04 -2.340108e-04 -2.445887e-04
## ASV2942     -1.554458e-05 -1.621667e-05 -1.691439e-05 -1.763839e-05
## ASV3302      1.910413e-04  1.996138e-04  2.085463e-04  2.178516e-04
## ASV6515      7.377221e-05  7.683090e-05  7.999558e-05  8.326806e-05
## ASV6674     -2.141300e-04 -2.238525e-04 -2.339939e-04 -2.445702e-04
## ASV7296     -7.930468e-05 -8.300960e-05 -8.688357e-05 -9.093387e-05
## ASV7903      1.176547e-04  1.227839e-04  1.281157e-04  1.336563e-04
## ASV7943     -2.141120e-04 -2.238328e-04 -2.339723e-04 -2.445466e-04
## ASV8864      1.578085e-04  1.643352e-04  1.710862e-04  1.780653e-04
## ASV9389      2.023261e-05  2.071273e-05  2.117451e-05  2.161387e-05
## ASV9869     -2.141000e-04 -2.238196e-04 -2.339578e-04 -2.445306e-04
## ASV1051      2.140827e-04  2.238007e-04  2.339372e-04  2.445081e-04
## ASV13035    -9.455675e-06 -9.817909e-06 -1.018946e-05 -1.057008e-05
## ASV15744     5.693780e-06  6.268183e-06  6.897489e-06  7.586712e-06
## ASV2526      2.268316e-05  2.352233e-05  2.438097e-05  2.525841e-05
## ASV1156      1.120679e-04  1.170929e-04  1.223289e-04  1.277838e-04
## ASV13562    -2.140728e-04 -2.237899e-04 -2.339254e-04 -2.444953e-04
## ASV1438      1.872198e-04  1.959524e-04  2.050843e-04  2.146329e-04
## ASV2268     -2.140639e-04 -2.237802e-04 -2.339149e-04 -2.444838e-04
## ASV2797      1.027806e-04  1.076849e-04  1.128234e-04  1.182072e-04
## ASV3744      2.385628e-04  2.495946e-04  2.611201e-04  2.731597e-04
## ASV8076     -2.306527e-04 -2.411392e-04 -2.520788e-04 -2.634888e-04
## ASV7055      9.891845e-05  1.037535e-04  1.088295e-04  1.141590e-04
## ASV7493     -1.954691e-04 -2.044099e-04 -2.137424e-04 -2.234820e-04
## ASV1201      4.757234e-04  4.972677e-04  5.197364e-04  5.431645e-04
## ASV5736     -4.115221e-04 -4.304951e-04 -4.503129e-04 -4.710104e-04
## ASV0558      1.990946e-04  2.084215e-04  2.181766e-04  2.283788e-04
## ASV14399    -2.852307e-04 -2.981269e-04 -3.115747e-04 -3.255949e-04
## ASV2992     -1.613504e-05 -1.685122e-05 -1.759672e-05 -1.837254e-05
## ASV4303     -2.095209e-04 -2.190279e-04 -2.289440e-04 -2.392847e-04
## ASV0565     -2.385789e-04 -2.494992e-04 -2.608998e-04 -2.727999e-04
## ASV0977     -3.556242e-04 -3.711186e-04 -3.872257e-04 -4.039643e-04
## ASV0140      1.791065e-04  1.872306e-04  1.957044e-04  2.045410e-04
## ASV14421    -2.148740e-04 -2.246702e-04 -2.348927e-04 -2.455581e-04
## ASV16909    -4.779177e-05 -5.007401e-05 -5.246506e-05 -5.497002e-05
## ASV3762     -2.148533e-04 -2.246476e-04 -2.348679e-04 -2.455310e-04
## ASV7141     -2.148359e-04 -2.246285e-04 -2.348471e-04 -2.455082e-04
## ASV3291      3.413499e-04  3.571855e-04  3.737356e-04  3.910308e-04
## ASV10440    -2.148157e-04 -2.246064e-04 -2.348229e-04 -2.454818e-04
## ASV10802     6.556423e-05  6.850611e-05  7.157163e-05  7.476522e-05
## ASV1698      3.583478e-05  3.758009e-05  3.941196e-05  4.133476e-05
## ASV2121      2.148028e-04  2.245923e-04  2.348075e-04  2.454650e-04
## ASV3549     -3.033212e-04 -3.171885e-04 -3.316625e-04 -3.467672e-04
## ASV6379      2.538189e-04  2.651085e-04  2.768641e-04  2.891018e-04
## ASV6824     -2.147643e-04 -2.245503e-04 -2.347616e-04 -2.454148e-04
## ASV8254      2.230395e-05  2.341436e-05  2.458176e-05  2.580918e-05
## ASV9951      9.449028e-05  9.896140e-05  1.036424e-04  1.085428e-04
## ASV1515     -8.996334e-05 -9.388336e-05 -9.795682e-05 -1.021881e-04
## ASV4327      6.552318e-05  6.851844e-05  7.164499e-05  7.490809e-05
## ASV0341     -9.963865e-05 -1.043572e-04 -1.092974e-04 -1.144692e-04
## ASV5562     -1.753112e-04 -1.835381e-04 -1.921452e-04 -2.011496e-04
## ASV1412      4.809637e-04  5.030260e-04  5.260618e-04  5.501104e-04
## ASV0154     -3.869418e-04 -4.048674e-04 -4.235999e-04 -4.431736e-04
## ASV3163     -1.791504e-04 -1.872538e-04 -1.957047e-04 -2.045163e-04
## ASV1782     -2.854375e-04 -2.984853e-04 -3.121032e-04 -3.263135e-04
## ASV3993     -3.098936e-05 -3.224215e-05 -3.353470e-05 -3.486723e-05
## ASV3164      1.373883e-04  1.434696e-04  1.497983e-04  1.563825e-04
## ASV1024      1.740900e-05  1.834426e-05  1.933381e-05  2.038110e-05
## ASV0771     -3.903935e-04 -4.078484e-04 -4.260311e-04 -4.449674e-04
## ASV2223     -1.726879e-04 -1.809066e-04 -1.895134e-04 -1.985262e-04
## ASV1638      6.457218e-04  6.749518e-04  7.054348e-04  7.372185e-04
## ASV0232     -1.895240e-04 -1.981366e-04 -2.071216e-04 -2.164933e-04
## ASV6771     -2.097877e-04 -2.196244e-04 -2.299133e-04 -2.406741e-04
## ASV4243     -8.262401e-05 -8.616092e-05 -8.983334e-05 -9.364528e-05
## ASV0162     -3.869614e-04 -4.046490e-04 -4.231089e-04 -4.423713e-04
## ASV0049      2.672946e-05  2.796944e-05  2.926557e-05  3.062027e-05
## ASV4697     -2.157753e-04 -2.256549e-04 -2.359682e-04 -2.467326e-04
## ASV12326     6.883093e-05  7.179745e-05  7.487732e-05  7.807355e-05
## ASV12586    -2.157605e-04 -2.256386e-04 -2.359504e-04 -2.467131e-04
## ASV1879      1.708171e-04  1.786533e-04  1.868344e-04  1.953744e-04
## ASV2864      4.708878e-04  4.926634e-04  5.154152e-04  5.391841e-04
## ASV3111     -1.254766e-04 -1.311997e-04 -1.371721e-04 -1.434035e-04
## ASV5633     -1.204026e-04 -1.258608e-04 -1.315536e-04 -1.374899e-04
## ASV5864      7.319206e-05  7.612732e-05  7.915402e-05  8.227252e-05
## ASV6364      1.037194e-04  1.086529e-04  1.138203e-04  1.192328e-04
## ASV1598      1.332140e-04  1.393411e-04  1.457410e-04  1.524249e-04
## ASV2649     -7.927729e-05 -8.315313e-05 -8.722178e-05 -9.149300e-05
## ASV4664      1.776495e-04  1.855936e-04  1.938700e-04  2.024904e-04
## ASV2654      2.991994e-04  3.128333e-04  3.270595e-04  3.419010e-04
## ASV6636     -2.075109e-05 -2.199166e-05 -2.331214e-05 -2.471787e-05
## ASV3334      2.228819e-04  2.334088e-04  2.444273e-04  2.559601e-04
## ASV0046     -3.972653e-04 -4.159274e-04 -4.354528e-04 -4.558800e-04
## ASV0661      4.021939e-04  4.202773e-04  4.391252e-04  4.587656e-04
## ASV0774      1.805278e-04  1.888142e-04  1.974658e-04  2.064974e-04
## ASV3815      2.157354e-04  2.254861e-04  2.356528e-04  2.462513e-04
## ASV0575      2.174012e-04  2.269875e-04  2.369623e-04  2.473384e-04
## ASV1953     -3.003801e-04 -3.141198e-04 -3.284609e-04 -3.434271e-04
## ASV0610      9.055083e-05  9.456406e-05  9.874183e-05  1.030897e-04
## ASV0245     -1.097225e-04 -1.147769e-04 -1.200561e-04 -1.255694e-04
## ASV3805     -1.588558e-04 -1.654034e-04 -1.721766e-04 -1.791792e-04
## ASV1182      4.483650e-04  4.693014e-04  4.911956e-04  5.140893e-04
## ASV1941      1.055174e-06  1.155843e-06  1.265980e-06  1.386455e-06
## ASV0080     -5.274757e-04 -5.515111e-04 -5.765908e-04 -6.027555e-04
## ASV1033      1.575404e-04  1.647574e-04  1.722916e-04  1.801558e-04
## ASV5330     -1.893765e-04 -1.979480e-04 -2.068863e-04 -2.162052e-04
## ASV9702     -2.898958e-04 -3.025006e-04 -3.156013e-04 -3.292131e-04
## ASV0358      7.786725e-06  7.993816e-06  8.196143e-06  8.392238e-06
## ASV2225      1.497430e-04  1.565308e-04  1.636101e-04  1.709920e-04
## ASV2606      6.868220e-06  7.043421e-06  7.213101e-06  7.375780e-06
## ASV3510     -2.332225e-04 -2.438955e-04 -2.550366e-04 -2.666643e-04
## ASV3069      7.993445e-05  8.330522e-05  8.679914e-05  9.041910e-05
## ASV3849      1.448988e-04  1.513411e-04  1.580486e-04  1.650300e-04
## ASV1810     -3.648415e-04 -3.808634e-04 -3.975302e-04 -4.148628e-04
## ASV2046      5.353367e-04  5.600059e-04  5.857726e-04  6.126817e-04
## ASV2451     -6.480151e-05 -6.807914e-05 -7.152838e-05 -7.515849e-05
## ASV4047      2.796700e-04  2.923819e-04  3.056438e-04  3.194770e-04
## ASV7402     -2.208141e-04 -2.311522e-04 -2.419641e-04 -2.532706e-04
## ASV8250      2.710905e-04  2.837063e-04  2.968949e-04  3.106811e-04
## ASV3468      2.329085e-04  2.434879e-04  2.545242e-04  2.660349e-04
## ASV3521      4.788713e-04  5.008664e-04  5.238341e-04  5.478140e-04
## ASV6363     -1.626084e-04 -1.702916e-04 -1.783331e-04 -1.867490e-04
## ASV6444      1.087627e-04  1.139034e-04  1.192858e-04  1.249214e-04
## ASV8231      1.258845e-04  1.315375e-04  1.374292e-04  1.435681e-04
## ASV0196     -7.177327e-04 -7.503994e-04 -7.844827e-04 -8.200377e-04
## ASV12801    -2.208233e-04 -2.311621e-04 -2.419749e-04 -2.532822e-04
## ASV12906    -2.208049e-04 -2.311420e-04 -2.419528e-04 -2.532581e-04
## ASV13040    -2.207865e-04 -2.311218e-04 -2.419307e-04 -2.532339e-04
## ASV1313     -2.236729e-05 -2.364784e-05 -2.500785e-05 -2.645256e-05
## ASV14008     6.227647e-05  6.532915e-05  6.853611e-05  7.190561e-05
## ASV1546      8.528393e-05  8.889202e-05  9.263179e-05  9.650615e-05
## ASV1637      4.147096e-04  4.336470e-04  4.534105e-04  4.740327e-04
## ASV17076     1.801438e-04  1.881618e-04  1.965108e-04  2.052021e-04
## ASV2061      6.173076e-04  6.450861e-04  6.740405e-04  7.042138e-04
## ASV2177      2.548361e-04  2.668672e-04  2.794605e-04  2.926415e-04
## ASV2943      3.758092e-04  3.928656e-04  4.106564e-04  4.292097e-04
## ASV3020      3.313008e-04  3.462328e-04  3.617986e-04  3.780215e-04
## ASV30254     1.634810e-05  1.680945e-05  1.726574e-05  1.771463e-05
## ASV3219      4.648487e-04  4.858376e-04  5.077215e-04  5.305337e-04
## ASV3352      4.059274e-04  4.246208e-04  4.441454e-04  4.645354e-04
## ASV3355      1.741198e-04  1.822727e-04  1.907991e-04  1.997151e-04
## ASV3377      3.153434e-04  3.298449e-04  3.449896e-04  3.608039e-04
## ASV3449      1.837120e-04  1.918242e-04  2.002654e-04  2.090465e-04
## ASV3893      2.207669e-04  2.311002e-04  2.419070e-04  2.532077e-04
## ASV4326      1.296653e-04  1.352964e-04  1.411473e-04  1.472242e-04
## ASV5016     -2.207540e-04 -2.310861e-04 -2.418914e-04 -2.531906e-04
## ASV5152      1.720597e-04  1.793921e-04  1.869977e-04  1.948829e-04
## ASV5666     -8.432208e-06 -8.991209e-06 -9.589731e-06 -1.023059e-05
## ASV5802     -2.261795e-04 -2.367484e-04 -2.478000e-04 -2.593551e-04
## ASV6070      1.571708e-04  1.641059e-04  1.713218e-04  1.788277e-04
## ASV6488      1.364209e-04  1.425861e-04  1.490147e-04  1.557165e-04
## ASV6562     -2.207239e-04 -2.310531e-04 -2.418552e-04 -2.531508e-04
## ASV6930      1.612993e-04  1.684257e-04  1.758416e-04  1.835564e-04
## ASV7243      2.919784e-04  3.050942e-04  3.187629e-04  3.330045e-04
## ASV7506      1.856105e-04  1.938675e-04  2.024652e-04  2.114150e-04
## ASV7553     -2.207104e-04 -2.310381e-04 -2.418388e-04 -2.531328e-04
## ASV8064      1.261068e-04  1.317239e-04  1.375731e-04  1.436621e-04
## ASV8434     -1.226425e-04 -1.284958e-04 -1.346271e-04 -1.410492e-04
## ASV8858     -2.206880e-04 -2.310137e-04 -2.418119e-04 -2.531033e-04
## ASV2600      1.270046e-04  1.329457e-04  1.391582e-04  1.456541e-04
## ASV3398      4.780038e-04  5.000234e-04  5.230228e-04  5.470422e-04
## ASV4584     -2.206612e-04 -2.309842e-04 -2.417797e-04 -2.530680e-04
## ASV4864      2.418836e-04  2.529130e-04  2.644226e-04  2.764314e-04
## ASV0082     -9.445543e-04 -9.877160e-04 -1.032766e-03 -1.079778e-03
## ASV9626      1.950834e-04  2.040427e-04  2.133975e-04  2.231638e-04
## ASV1617      8.539668e-05  8.893879e-05  9.260362e-05  9.639326e-05
## ASV2765     -5.036788e-05 -5.288469e-05 -5.553058e-05 -5.831229e-05
## ASV2167     -2.933610e-04 -3.067453e-04 -3.207130e-04 -3.352868e-04
## ASV1628      1.859770e-04  1.939266e-04  2.021755e-04  2.107315e-04
## ASV3260     -4.653397e-05 -4.851586e-05 -5.057099e-05 -5.270102e-05
## ASV3645      2.720005e-05  2.865510e-05  3.019124e-05  3.181299e-05
## ASV6057     -2.799384e-04 -2.927157e-04 -3.060505e-04 -3.199647e-04
## ASV0662     -3.740247e-05 -3.898455e-05 -4.062439e-05 -4.232327e-05
## ASV4267     -3.577000e-05 -3.749990e-05 -3.931347e-05 -4.121467e-05
## ASV1070      2.990308e-04  3.130316e-04  3.276765e-04  3.429939e-04
## ASV0633     -7.749089e-05 -8.090229e-05 -8.445113e-05 -8.814179e-05
## ASV0333      3.069312e-04  3.211005e-04  3.359034e-04  3.513664e-04
## ASV0966      2.333534e-04  2.440946e-04  2.553121e-04  2.670253e-04
## ASV1848      3.363690e-04  3.521766e-04  3.687163e-04  3.860210e-04
## ASV13390    -2.143685e-04 -2.241172e-04 -2.342877e-04 -2.448964e-04
## ASV14901    -2.143511e-04 -2.240982e-04 -2.342670e-04 -2.448737e-04
## ASV1676     -2.465153e-04 -2.574635e-04 -2.688614e-04 -2.807244e-04
## ASV1756     -2.587506e-05 -2.704013e-05 -2.825439e-05 -2.951963e-05
## ASV22537    -2.968866e-05 -3.095443e-05 -3.226734e-05 -3.362854e-05
## ASV3303     -3.516106e-06 -3.757195e-06 -4.015676e-06 -4.292789e-06
## ASV4030     -8.954173e-05 -9.354110e-05 -9.770680e-05 -1.020446e-04
## ASV4871      1.713502e-04  1.792864e-04  1.875798e-04  1.962455e-04
## ASV5536      1.060136e-05  1.108632e-05  1.159281e-05  1.212175e-05
## ASV5700      7.672643e-05  8.023301e-05  8.389262e-05  8.771124e-05
## ASV8957      1.422932e-04  1.482581e-04  1.544359e-04  1.608309e-04
## ASV11210     1.369337e-04  1.435631e-04  1.505173e-04  1.578125e-04
## ASV7585     -2.143445e-04 -2.240910e-04 -2.342591e-04 -2.448651e-04
## ASV8596     -2.143272e-04 -2.240720e-04 -2.342383e-04 -2.448425e-04
## ASV9532     -8.607876e-05 -8.989607e-05 -9.386952e-05 -9.800432e-05
## ASV4254      1.551744e-04  1.623788e-04  1.699087e-04  1.777779e-04
## ASV13299    -2.143118e-04 -2.240552e-04 -2.342200e-04 -2.448225e-04
## ASV15627    -2.142944e-04 -2.240362e-04 -2.341993e-04 -2.447998e-04
## ASV6302     -1.706384e-04 -1.777654e-04 -1.851469e-04 -1.927885e-04
## ASV3040      8.621529e-05  9.017534e-05  9.431027e-05  9.862717e-05
## ASV0632      1.755613e-04  1.836617e-04  1.921239e-04  2.009632e-04
## ASV3694      2.792384e-04  2.920105e-04  3.053421e-04  3.192553e-04
## ASV1592     -5.228777e-05 -5.440599e-05 -5.659293e-05 -5.884927e-05
## ASV0538      1.423214e-04  1.490137e-04  1.560172e-04  1.633461e-04
## ASV0832      3.119256e-04  3.261488e-04  3.409915e-04  3.564780e-04
## ASV0727      2.355983e-04  2.466585e-04  2.582302e-04  2.703361e-04
## ASV1165     -3.027012e-04 -3.166384e-04 -3.311952e-04 -3.463970e-04
## ASV1325      3.365340e-05  3.579442e-05  3.808560e-05  4.053821e-05
## ASV0819      5.432013e-04  5.681795e-04  5.942654e-04  6.215042e-04
## ASV2251      2.911663e-04  3.035616e-04  3.164168e-04  3.297431e-04
## ASV0100     -1.865057e-05 -1.947259e-05 -2.032754e-05 -2.121641e-05
## ASV0444     -1.448180e-04 -1.514833e-04 -1.584456e-04 -1.657177e-04
## ASV0800      7.097577e-04  7.415013e-04  7.745721e-04  8.090174e-04
## ASV2432      1.619345e-05  1.668948e-05  1.718641e-05  1.768260e-05
## ASV2883      1.985932e-05  2.060627e-05  2.137094e-05  2.215263e-05
## ASV3894      2.261309e-05  2.336691e-05  2.412791e-05  2.489401e-05
## ASV2367      4.964026e-04  5.190101e-04  5.425997e-04  5.672097e-04
## ASV3724     -2.951776e-04 -3.085208e-04 -3.224343e-04 -3.369394e-04
## ASV2112     -2.519363e-04 -2.635332e-04 -2.756444e-04 -2.882910e-04
## ASV3661      8.719495e-05  9.129367e-05  9.558247e-05  1.000699e-04
## ASV2096     -1.823951e-04 -1.910131e-04 -2.000323e-04 -2.094705e-04
## ASV3551     -2.112460e-04 -2.206668e-04 -2.304773e-04 -2.406909e-04
## ASV11343    -7.144555e-06 -7.579348e-06 -8.043385e-06 -8.538796e-06
## ASV2051      1.810439e-04  1.894480e-04  1.982335e-04  2.074170e-04
## ASV2617     -2.486843e-04 -2.600098e-04 -2.718270e-04 -2.841550e-04
## ASV0125     -1.100759e-04 -1.151468e-04 -1.204425e-04 -1.259723e-04
## ASV0372      3.790115e-04  3.962731e-04  4.142842e-04  4.330740e-04
## ASV6751     -2.832249e-04 -2.959877e-04 -3.092924e-04 -3.231592e-04
## ASV10810     6.341061e-05  6.632343e-05  6.936580e-05  7.254317e-05
## ASV0461     -1.616860e-04 -1.692096e-04 -1.770747e-04 -1.852961e-04
## ASV1945     -9.589435e-05 -1.004230e-04 -1.051633e-04 -1.101250e-04
## ASV0882     -8.199896e-05 -8.614468e-05 -9.050815e-05 -9.510130e-05
## ASV4040     -4.121012e-05 -4.309774e-05 -4.506726e-05 -4.712170e-05
## ASV0109     -2.811642e-06 -2.912568e-06 -3.015152e-06 -3.119180e-06
## ASV0174      1.273266e-04  1.326869e-04  1.382391e-04  1.439869e-04
## ASV2851      2.179159e-04  2.274577e-04  2.373784e-04  2.476893e-04
## ASV5312      3.685147e-05  3.851870e-05  4.025912e-05  4.207591e-05
## ASV9402     -3.035879e-04 -3.173279e-04 -3.316563e-04 -3.465955e-04
## ASV4870     -2.452698e-04 -2.563002e-04 -2.677969e-04 -2.797770e-04
## ASV0589      2.931800e-04  3.065751e-04  3.205558e-04  3.351454e-04
## ASV1221      6.849615e-07  7.461240e-07  8.124809e-07  8.844373e-07
## ASV6028     -2.836794e-04 -2.966007e-04 -3.100838e-04 -3.241506e-04
## ASV5106     -1.067563e-04 -1.114789e-04 -1.163939e-04 -1.215076e-04
## ASV4977     -3.849248e-05 -4.061403e-05 -4.286095e-05 -4.524107e-05
## ASV5715     -1.863759e-04 -1.948789e-04 -2.037527e-04 -2.130119e-04
## ASV4182      7.035262e-05  7.384942e-05  7.752589e-05  8.139173e-05
## ASV2383     -1.540181e-05 -1.643382e-05 -1.754215e-05 -1.873280e-05
## ASV3985      3.347550e-04  3.503717e-04  3.667015e-04  3.837753e-04
## ASV2787     -2.515044e-04 -2.626543e-04 -2.742618e-04 -2.863424e-04
## ASV6756     -2.164802e-04 -2.264829e-04 -2.369326e-04 -2.478479e-04
## ASV1634     -3.463818e-04 -3.619130e-04 -3.780963e-04 -3.949552e-04
## ASV0649     -1.060782e-04 -1.109645e-04 -1.160675e-04 -1.213960e-04
## ASV1591     -6.622112e-06 -7.221900e-06 -7.873878e-06 -8.582301e-06
## ASV1854      3.596279e-04  3.764589e-04  3.940627e-04  4.124731e-04
## ASV4205      2.398101e-04  2.510345e-04  2.627746e-04  2.750530e-04
## ASV3293     -1.385431e-04 -1.447434e-04 -1.512031e-04 -1.579314e-04
## ASV1631      1.629145e-04  1.703748e-04  1.781634e-04  1.862938e-04
## ASV1747     -9.267427e-05 -9.712972e-05 -1.018004e-04 -1.066966e-04
## ASV5634      7.380603e-05  7.717347e-05  8.068819e-05  8.435612e-05
## ASV0965     -1.162031e-04 -1.214583e-04 -1.269387e-04 -1.326528e-04
## ASV1094      2.005242e-04  2.096002e-04  2.190657e-04  2.289355e-04
## ASV2744     -6.746395e-06 -7.357082e-06 -8.020859e-06 -8.742048e-06
## ASV7212     -3.039200e-04 -3.180473e-04 -3.328133e-04 -3.482449e-04
## ASV0344     -2.013527e-04 -2.105696e-04 -2.201912e-04 -2.302337e-04
## ASV11812    -2.180619e-04 -2.281494e-04 -2.386888e-04 -2.496990e-04
## ASV7867     -3.164203e-05 -3.319395e-05 -3.482297e-05 -3.653291e-05
## ASV6670      1.979261e-04  2.065919e-04  2.156036e-04  2.249723e-04
## ASV10991     3.636133e-06  3.348887e-06  3.008503e-06  2.609351e-06
## ASV1281      3.897812e-04  4.081566e-04  4.273879e-04  4.475139e-04
## ASV12845    -2.180464e-04 -2.281324e-04 -2.386702e-04 -2.496785e-04
## ASV1833     -2.180285e-04 -2.281128e-04 -2.386487e-04 -2.496550e-04
## ASV2211      1.416269e-04  1.478152e-04  1.542487e-04  1.609350e-04
## ASV3920      3.069843e-04  3.207252e-04  3.350403e-04  3.499499e-04
## ASV4545     -2.477275e-04 -2.592053e-04 -2.711990e-04 -2.837303e-04
## ASV4710     -2.704857e-04 -2.829867e-04 -2.960468e-04 -3.096892e-04
## ASV4978      4.309424e-05  4.510291e-05  4.720315e-05  4.939893e-05
## ASV9630     -7.583905e-06 -7.958315e-06 -8.351523e-06 -8.764475e-06
## ASV9797     -7.728571e-06 -8.359181e-06 -9.042506e-06 -9.782869e-06
## ASV13469    -2.179805e-04 -2.280602e-04 -2.385911e-04 -2.495918e-04
## ASV14961    -7.955266e-05 -8.322061e-05 -8.705163e-05 -9.105238e-05
## ASV6259      1.223613e-04  1.277823e-04  1.334246e-04  1.392957e-04
## ASV6294     -1.552065e-04 -1.623887e-04 -1.698928e-04 -1.777321e-04
## ASV6883     -7.276309e-05 -7.623158e-05 -7.986450e-05 -8.366948e-05
## ASV7041     -1.801818e-04 -1.886776e-04 -1.975682e-04 -2.068712e-04
## ASV4363     -2.112092e-04 -2.206702e-04 -2.305278e-04 -2.407963e-04
## ASV1784     -3.079506e-04 -3.220316e-04 -3.367295e-04 -3.520687e-04
## ASV2140      2.743622e-05  2.874110e-05  3.010698e-05  3.153651e-05
## ASV3202      2.111818e-04  2.206403e-04  2.304951e-04  2.407607e-04
## ASV6017     -2.111650e-04 -2.206219e-04 -2.304751e-04 -2.407388e-04
## ASV9129      1.061521e-04  1.108255e-04  1.156867e-04  1.207416e-04
## ASV0917      2.166079e-04  2.263226e-04  2.364458e-04  2.469922e-04
## ASV10584    -2.998924e-06 -2.890014e-06 -2.754740e-06 -2.590234e-06
## ASV11218     1.373710e-04  1.434388e-04  1.497524e-04  1.563198e-04
## ASV11229     2.015075e-05  2.131494e-05  2.255136e-05  2.386468e-05
## ASV11604    -2.427651e-05 -2.550009e-05 -2.678748e-05 -2.814210e-05
## ASV2103     -2.480425e-04 -2.592617e-04 -2.709615e-04 -2.831603e-04
## ASV2165     -2.111176e-04 -2.205702e-04 -2.304187e-04 -2.406773e-04
## ASV2340      2.342780e-04  2.444580e-04  2.550359e-04  2.660234e-04
## ASV3738     -2.110979e-04 -2.205487e-04 -2.303953e-04 -2.406518e-04
## ASV4012      6.407923e-05  6.694370e-05  6.992736e-05  7.303436e-05
## ASV4094     -2.110839e-04 -2.205334e-04 -2.303785e-04 -2.406335e-04
## ASV4454     -2.110670e-04 -2.205150e-04 -2.303585e-04 -2.406116e-04
## ASV7031      5.002966e-05  5.246030e-05  5.501042e-05  5.768593e-05
## ASV7087     -8.056285e-05 -8.399756e-05 -8.756067e-05 -9.125541e-05
## ASV4159      1.239085e-05  1.290041e-05  1.342688e-05  1.397044e-05
## ASV5084     -2.110481e-04 -2.204944e-04 -2.303360e-04 -2.405871e-04
## ASV6584     -2.110313e-04 -2.204760e-04 -2.303160e-04 -2.405653e-04
## ASV9614     -2.110144e-04 -2.204577e-04 -2.302960e-04 -2.405434e-04
## ASV16068    -2.109976e-04 -2.204393e-04 -2.302759e-04 -2.405216e-04
## ASV2141     -2.803886e-04 -2.925381e-04 -3.051622e-04 -3.182753e-04
## ASV0395     -1.990368e-05 -2.087250e-05 -2.188949e-05 -2.295713e-05
## ASV5640     -4.927217e-05 -5.164747e-05 -5.413746e-05 -5.674757e-05
## ASV2854     -2.372572e-04 -2.478020e-04 -2.587818e-04 -2.702115e-04
## ASV3825     -4.183630e-04 -4.374008e-04 -4.572645e-04 -4.779863e-04
## ASV0481      4.556109e-04  4.758083e-04  4.968350e-04  5.187194e-04
## ASV3304      2.130589e-05  2.231625e-05  2.337444e-05  2.448274e-05
## ASV0445      2.774170e-04  2.899395e-04  3.029956e-04  3.166052e-04
## ASV1845     -1.459088e-04 -1.527397e-04 -1.598840e-04 -1.673554e-04
## ASV3110     -1.607408e-04 -1.679960e-04 -1.755625e-04 -1.834522e-04
##                                                                    
## (Intercept) -4.233900e-06 -4.916363e-06 -5.706143e-06 -6.619401e-06
## ASV1236      2.599698e-04  2.714880e-04  2.834758e-04  2.959488e-04
## ASV0421     -4.555862e-04 -4.756031e-04 -4.964248e-04 -5.180772e-04
## ASV0691     -3.905978e-04 -4.071273e-04 -4.242658e-04 -4.420281e-04
## ASV0899      1.269440e-06  1.866026e-06  2.533200e-06  3.277139e-06
## ASV1004      5.185855e-04  5.414099e-04  5.651540e-04  5.898476e-04
## ASV1041     -3.548459e-04 -3.706534e-04 -3.871144e-04 -4.042514e-04
## ASV1058      4.833417e-04  5.046924e-04  5.269121e-04  5.500298e-04
## ASV12542     1.453804e-04  1.515020e-04  1.578467e-04  1.644196e-04
## ASV1294      5.655086e-04  5.908067e-04  6.171622e-04  6.446128e-04
## ASV13113     1.999424e-04  2.090565e-04  2.185679e-04  2.284924e-04
## ASV1318      4.942390e-04  5.162679e-04  5.392091e-04  5.630942e-04
## ASV2269     -1.506629e-04 -1.575263e-04 -1.646848e-04 -1.721494e-04
## ASV2542      3.221639e-04  3.371697e-04  3.528572e-04  3.692559e-04
## ASV2660     -2.853490e-04 -2.979580e-04 -3.110778e-04 -3.247250e-04
## ASV2737     -2.043277e-05 -2.169288e-05 -2.303373e-05 -2.446031e-05
## ASV2840      3.691833e-04  3.849673e-04  4.013458e-04  4.183340e-04
## ASV3053      1.831506e-05  1.900617e-05  1.971741e-05  2.044906e-05
## ASV3077      1.165741e-04  1.216791e-04  1.269899e-04  1.325137e-04
## ASV3134      4.103789e-04  4.293829e-04  4.492433e-04  4.699966e-04
## ASV3140      1.843684e-04  1.929867e-04  2.019954e-04  2.114106e-04
## ASV3579      7.204083e-05  7.556974e-05  7.927673e-05  8.317122e-05
## ASV6119     -1.506322e-04 -1.574928e-04 -1.646481e-04 -1.721093e-04
## ASV7557     -1.506175e-04 -1.574767e-04 -1.646305e-04 -1.720900e-04
## ASV8422      7.493782e-05  7.789895e-05  8.095176e-05  8.409704e-05
## ASV1086     -3.903780e-05 -4.065832e-05 -4.233795e-05 -4.407834e-05
## ASV1310      2.772197e-04  2.895308e-04  3.023491e-04  3.156919e-04
## ASV15750    -7.324321e-05 -7.661265e-05 -8.012824e-05 -8.379528e-05
## ASV16905    -1.506096e-04 -1.574679e-04 -1.646209e-04 -1.720794e-04
## ASV2033      2.710445e-04  2.832715e-04  2.960196e-04  3.093085e-04
## ASV2089      1.039860e-04  1.087656e-04  1.137535e-04  1.189576e-04
## ASV2127      3.952202e-04  4.125138e-04  4.304951e-04  4.491853e-04
## ASV2725      4.484086e-04  4.678611e-04  4.880742e-04  5.090704e-04
## ASV2804     -1.506042e-04 -1.574620e-04 -1.646144e-04 -1.720722e-04
## ASV3075      2.834908e-04  2.959833e-04  3.089833e-04  3.225077e-04
## ASV3327      2.677099e-04  2.798712e-04  2.925595e-04  3.057953e-04
## ASV3342      2.981203e-04  3.118201e-04  3.261237e-04  3.410552e-04
## ASV3532     -2.672734e-04 -2.794499e-04 -2.921526e-04 -3.054016e-04
## ASV3600      3.325838e-04  3.474647e-04  3.629701e-04  3.791225e-04
## ASV4013      2.784254e-04  2.906576e-04  3.033815e-04  3.166130e-04
## ASV4136      2.809241e-04  2.933378e-04  3.062558e-04  3.196948e-04
## ASV4195      1.505815e-04  1.574371e-04  1.645872e-04  1.720425e-04
## ASV4407     -1.505668e-04 -1.574210e-04 -1.645696e-04 -1.720232e-04
## ASV4717      1.533400e-06  1.211703e-06  8.446941e-07  4.283361e-07
## ASV6794      1.441315e-04  1.500671e-04  1.562084e-04  1.625596e-04
## ASV8324     -1.505604e-04 -1.574139e-04 -1.645616e-04 -1.720144e-04
## ASV8981     -4.319437e-05 -4.512716e-05 -4.713807e-05 -4.922935e-05
## ASV9859      1.120831e-04  1.173979e-04  1.229647e-04  1.287956e-04
## ASV0936     -2.272722e-04 -2.372936e-04 -2.477228e-04 -2.585738e-04
## ASV12683    -2.820900e-05 -2.973886e-05 -3.135406e-05 -3.305923e-05
## ASV1293      3.371226e-04  3.519047e-04  3.672756e-04  3.832533e-04
## ASV13055    -3.931751e-05 -4.115189e-05 -4.306668e-05 -4.506471e-05
## ASV17063    -1.505335e-04 -1.573846e-04 -1.645297e-04 -1.719796e-04
## ASV2228      1.505188e-04  1.573685e-04  1.645121e-04  1.719604e-04
## ASV2769     -3.144116e-05 -3.288503e-05 -3.439049e-05 -3.595962e-05
## ASV2803      6.233483e-05  6.467921e-05  6.708489e-05  6.955118e-05
## ASV2896      1.804983e-04  1.885063e-04  1.968465e-04  2.055310e-04
## ASV3062      5.464953e-05  5.725348e-05  5.998234e-05  6.284217e-05
## ASV3107      2.197987e-04  2.296501e-04  2.399167e-04  2.506140e-04
## ASV3265      4.360813e-04  4.551016e-04  4.748727e-04  4.954173e-04
## ASV3666     -1.294981e-05 -1.366893e-05 -1.442843e-05 -1.523041e-05
## ASV4497      1.026064e-04  1.070860e-04  1.117457e-04  1.165914e-04
## ASV6914     -5.727926e-05 -6.012929e-05 -6.312154e-05 -6.626277e-05
## ASV0576     -5.116522e-04 -5.335407e-04 -5.562576e-04 -5.798251e-04
## ASV0673      1.399781e-04  1.467041e-04  1.537523e-04  1.611377e-04
## ASV0772      1.524196e-04  1.590193e-04  1.658779e-04  1.730036e-04
## ASV0862     -1.238090e-04 -1.289999e-04 -1.343783e-04 -1.399486e-04
## ASV0898      1.336611e-04  1.400277e-04  1.466941e-04  1.536736e-04
## ASV0910      2.880248e-04  3.015913e-04  3.157882e-04  3.306438e-04
## ASV0964     -1.862125e-04 -1.942844e-04 -2.026726e-04 -2.113867e-04
## ASV10059     1.318945e-04  1.380397e-04  1.444673e-04  1.511902e-04
## ASV10263    -1.505883e-04 -1.574442e-04 -1.645944e-04 -1.720498e-04
## ASV1088      1.515924e-04  1.586870e-04  1.661081e-04  1.738701e-04
## ASV1101      2.540419e-04  2.654083e-04  2.772502e-04  2.895847e-04
## ASV1183      1.687225e-04  1.765957e-04  1.848252e-04  1.934259e-04
## ASV11956     5.642655e-05  5.849059e-05  6.060267e-05  6.276150e-05
## ASV12774    -2.844606e-05 -3.005092e-05 -3.175005e-05 -3.354888e-05
## ASV1321      6.466310e-05  6.784808e-05  7.119330e-05  7.470694e-05
## ASV13793    -1.505684e-04 -1.574222e-04 -1.645703e-04 -1.720233e-04
## ASV14482    -1.853604e-05 -1.965295e-05 -2.083916e-05 -2.209873e-05
## ASV15483     9.801069e-05  1.022500e-04  1.066559e-04  1.112337e-04
## ASV2062      6.492759e-04  6.784702e-04  7.088990e-04  7.406074e-04
## ASV2132      2.905900e-04  3.036405e-04  3.172435e-04  3.314193e-04
## ASV2413      4.146842e-04  4.329207e-04  4.518942e-04  4.716290e-04
## ASV2490      2.739596e-04  2.859153e-04  2.983442e-04  3.112610e-04
## ASV2594      1.473156e-04  1.537753e-04  1.604973e-04  1.674907e-04
## ASV2822     -1.505879e-04 -1.574435e-04 -1.645934e-04 -1.720484e-04
## ASV2863      2.575621e-04  2.690066e-04  2.809209e-04  2.933209e-04
## ASV2910      3.255099e-04  3.395113e-04  3.540497e-04  3.691401e-04
## ASV2980      1.248064e-04  1.304822e-04  1.364006e-04  1.425704e-04
## ASV3307      1.505619e-04  1.574149e-04  1.645621e-04  1.720142e-04
## ASV3474      2.314920e-04  2.422898e-04  2.535818e-04  2.653897e-04
## ASV3502      4.738694e-04  4.949670e-04  5.169390e-04  5.398158e-04
## ASV4236      2.385638e-04  2.488753e-04  2.595871e-04  2.707107e-04
## ASV4842     -8.470206e-05 -8.869028e-05 -9.285980e-05 -9.721798e-05
## ASV4894     -1.505762e-04 -1.574306e-04 -1.645792e-04 -1.720327e-04
## ASV5290      1.787441e-04  1.867156e-04  1.950199e-04  2.036688e-04
## ASV5501      3.189740e-05  3.326085e-05  3.467867e-05  3.615294e-05
## ASV5795      1.188186e-04  1.241489e-04  1.297056e-04  1.354974e-04
## ASV5987     -1.505803e-04 -1.574350e-04 -1.645840e-04 -1.720380e-04
## ASV6267     -1.505656e-04 -1.574189e-04 -1.645664e-04 -1.720188e-04
## ASV6862      2.766384e-04  2.884142e-04  3.006309e-04  3.133000e-04
## ASV7145      4.689147e-05  4.867955e-05  5.051797e-05  5.240676e-05
## ASV7673     -1.505602e-04 -1.574129e-04 -1.645597e-04 -1.720114e-04
## ASV7789      5.055811e-05  5.295007e-05  5.545584e-05  5.808092e-05
## ASV7809     -2.214155e-05 -2.315552e-05 -2.421138e-05 -2.531025e-05
## ASV8002     -1.505478e-04 -1.573995e-04 -1.645451e-04 -1.719954e-04
## ASV8205      7.755883e-05  8.071025e-05  8.396744e-05  8.733217e-05
## ASV9155     -1.142914e-04 -1.195083e-04 -1.249495e-04 -1.306232e-04
## ASV9221     -2.481654e-05 -2.612243e-05 -2.749821e-05 -2.894745e-05
## ASV9311     -1.505251e-04 -1.573746e-04 -1.645178e-04 -1.719655e-04
## ASV9557     -1.505104e-04 -1.573585e-04 -1.645002e-04 -1.719463e-04
## ASV9936     -1.504957e-04 -1.573424e-04 -1.644826e-04 -1.719271e-04
## ASV1445      3.386281e-04  3.540035e-04  3.700434e-04  3.867733e-04
## ASV4232      2.833835e-04  2.963036e-04  3.097894e-04  3.238638e-04
## ASV6479     -2.050248e-06 -1.879856e-06 -1.675214e-06 -1.432243e-06
## ASV0142     -7.328006e-04 -7.646692e-04 -7.977904e-04 -8.322019e-04
## ASV0378     -2.406657e-04 -2.510328e-04 -2.617978e-04 -2.729717e-04
## ASV1122      4.455861e-04  4.657474e-04  4.867738e-04  5.086982e-04
## ASV0123     -7.183192e-04 -7.495597e-04 -7.820282e-04 -8.157617e-04
## ASV2064      7.053810e-05  7.335681e-05  7.626780e-05  7.927266e-05
## ASV4459     -8.527991e-05 -8.924701e-05 -9.339080e-05 -9.771824e-05
## ASV0448      1.370033e-04  1.439381e-04  1.512327e-04  1.589060e-04
## ASV0397      3.376831e-04  3.530399e-04  3.690588e-04  3.857649e-04
## ASV0485      4.674036e-04  4.882560e-04  5.099740e-04  5.325877e-04
## ASV1566      3.858729e-04  4.030071e-04  4.208476e-04  4.394188e-04
## ASV1365      2.482248e-04  2.591912e-04  2.706050e-04  2.824814e-04
## ASV1065      5.189407e-04  5.422817e-04  5.666081e-04  5.919555e-04
## ASV0722     -7.612510e-06 -7.772032e-06 -7.924889e-06 -8.070018e-06
## ASV12660    -2.481977e-04 -2.592320e-04 -2.707190e-04 -2.826738e-04
## ASV0223     -2.369348e-06 -2.124156e-06 -1.838304e-06 -1.507749e-06
## ASV0229      2.353869e-04  2.462294e-04  2.575519e-04  2.693737e-04
## ASV0877     -9.201825e-05 -9.608268e-05 -1.003107e-04 -1.047075e-04
## ASV0983      4.769254e-04  4.981037e-04  5.201515e-04  5.430980e-04
## ASV0626     -1.534918e-04 -1.597666e-04 -1.662506e-04 -1.729466e-04
## ASV4146     -3.011944e-05 -3.158524e-05 -3.312051e-05 -3.472817e-05
## ASV4175     -2.947300e-04 -3.080559e-04 -3.219488e-04 -3.364297e-04
## ASV2082     -1.677275e-05 -1.753166e-05 -1.832594e-05 -1.915753e-05
## ASV2272      2.096453e-04  2.191236e-04  2.290098e-04  2.393199e-04
## ASV2245     -2.557497e-04 -2.673227e-04 -2.793887e-04 -2.919658e-04
## ASV0590     -1.512909e-04 -1.582678e-04 -1.655566e-04 -1.731705e-04
## ASV0217     -2.250464e-04 -2.337466e-04 -2.426881e-04 -2.518686e-04
## ASV0416      2.378906e-04  2.481129e-04  2.587234e-04  2.697321e-04
## ASV1056      2.847715e-04  2.980357e-04  3.119023e-04  3.263969e-04
## ASV7777     -2.582771e-04 -2.701467e-04 -2.825389e-04 -2.954745e-04
## ASV0455      5.414463e-05  5.681962e-05  5.962669e-05  6.257203e-05
## ASV0604      6.026647e-05  6.351845e-05  6.695696e-05  7.059318e-05
## ASV6100     -2.404542e-04 -2.516184e-04 -2.632847e-04 -2.754740e-04
## ASV11359    -2.625691e-04 -2.743709e-04 -2.866684e-04 -2.994790e-04
## ASV6604      1.875649e-04  1.962610e-04  2.053511e-04  2.148523e-04
## ASV5004     -1.573945e-04 -1.646006e-04 -1.721201e-04 -1.799651e-04
## ASV1483     -1.435753e-04 -1.501049e-04 -1.569149e-04 -1.640156e-04
## ASV9773     -3.053033e-04 -3.193350e-04 -3.339853e-04 -3.492787e-04
## ASV4059      3.139831e-05  3.315323e-05  3.501606e-05  3.699414e-05
## ASV1193      4.885211e-04  5.106037e-04  5.336327e-04  5.576444e-04
## ASV4610     -4.425184e-05 -4.593495e-05 -4.766016e-05 -4.942628e-05
## ASV0742     -1.819351e-04 -1.895952e-04 -1.975321e-04 -2.057519e-04
## ASV1502     -3.537446e-06 -3.859649e-06 -4.207409e-06 -4.582373e-06
## ASV0195     -5.331887e-05 -5.593031e-05 -5.867223e-05 -6.155122e-05
## ASV1213      1.576561e-04  1.646357e-04  1.718990e-04  1.794552e-04
## ASV1648     -2.267755e-04 -2.372084e-04 -2.481020e-04 -2.594750e-04
## ASV6984     -1.678255e-04 -1.754856e-04 -1.834773e-04 -1.918131e-04
## ASV0396     -1.147865e-04 -1.188171e-04 -1.229202e-04 -1.270901e-04
## ASV4297      2.464330e-04  2.570976e-04  2.681777e-04  2.796859e-04
## ASV2622      5.648756e-04  5.896626e-04  6.154442e-04  6.422524e-04
## ASV3512      8.563357e-05  8.972093e-05  9.400532e-05  9.849647e-05
## ASV2411      1.980075e-04  2.072444e-04  2.169015e-04  2.269967e-04
## ASV2291     -4.459700e-05 -4.657905e-05 -4.864499e-05 -5.079817e-05
## ASV0807      2.383525e-04  2.499571e-04  2.621302e-04  2.748994e-04
## ASV1292      1.338477e-04  1.400030e-04  1.464301e-04  1.531401e-04
## ASV1035      5.940395e-05  6.186805e-05  6.441637e-05  6.705010e-05
## ASV0070     -1.344996e-04 -1.401350e-04 -1.459729e-04 -1.520179e-04
## ASV0255      5.210840e-05  5.428562e-05  5.653706e-05  5.886350e-05
## ASV0057     -5.797521e-04 -6.046902e-04 -6.305817e-04 -6.574528e-04
## ASV0077     -8.514269e-05 -8.859965e-05 -9.217191e-05 -9.586129e-05
## ASV0625      5.857385e-04  6.115690e-04  6.384456e-04  6.664026e-04
## ASV2464      2.863698e-04  2.989621e-04  3.120596e-04  3.256784e-04
## ASV1315      5.005482e-04  5.231564e-04  5.467338e-04  5.713176e-04
## ASV2673      3.764067e-04  3.940142e-04  4.124282e-04  4.316840e-04
## ASV2161      1.522142e-04  1.592558e-04  1.666152e-04  1.743061e-04
## ASV0337     -2.467871e-04 -2.579322e-04 -2.695547e-04 -2.816728e-04
## ASV7680     -2.885450e-04 -3.016077e-04 -3.152280e-04 -3.294264e-04
## ASV0611      6.236275e-04  6.519745e-04  6.815494e-04  7.124001e-04
## ASV3118     -2.144510e-04 -2.242694e-04 -2.345165e-04 -2.452088e-04
## ASV1284      2.344534e-04  2.454925e-04  2.570366e-04  2.691068e-04
## ASV0889      1.686681e-04  1.760885e-04  1.838096e-04  1.918415e-04
## ASV4649     -1.833215e-04 -1.917815e-04 -2.006171e-04 -2.098436e-04
## ASV1108     -2.338461e-04 -2.448956e-04 -2.564588e-04 -2.685585e-04
## ASV0738     -2.459308e-05 -2.454601e-05 -2.439355e-05 -2.412270e-05
## ASV0473      3.648428e-05  3.818548e-05  3.996311e-05  4.182029e-05
## ASV0598     -2.577597e-04 -2.688957e-04 -2.804624e-04 -2.924722e-04
## ASV0429      4.117636e-04  4.300724e-04  4.491368e-04  4.689826e-04
## ASV1549      4.179087e-04  4.374636e-04  4.579160e-04  4.793055e-04
## ASV1203      3.090467e-04  3.227292e-04  3.369700e-04  3.517876e-04
## ASV4532      1.265705e-05  1.309381e-05  1.353964e-05  1.399436e-05
## ASV0274     -3.060479e-04 -3.190438e-04 -3.325243e-04 -3.465019e-04
## ASV0163     -4.407872e-04 -4.595857e-04 -4.790889e-04 -4.993148e-04
## ASV1298      1.803618e-04  1.880919e-04  1.961142e-04  2.044363e-04
## ASV9424     -3.866317e-04 -4.044078e-04 -4.229687e-04 -4.423461e-04
## ASV0412      5.873754e-04  6.135829e-04  6.408794e-04  6.693031e-04
## ASV0284      2.591864e-04  2.703185e-04  2.818732e-04  2.938619e-04
## ASV0620     -2.001871e-04 -2.096232e-04 -2.194947e-04 -2.298206e-04
## ASV0153     -4.087235e-04 -4.274709e-04 -4.470460e-04 -4.674826e-04
## ASV0498      4.965512e-05  5.262180e-05  5.577584e-05  5.912904e-05
## ASV0097      2.901444e-04  3.033832e-04  3.171996e-04  3.316164e-04
## ASV0104     -1.346676e-03 -1.406917e-03 -1.469681e-03 -1.535058e-03
## ASV1282      2.391925e-04  2.501999e-04  2.616928e-04  2.736904e-04
## ASV3883     -1.329119e-04 -1.388542e-04 -1.450415e-04 -1.514819e-04
## ASV0801      1.429726e-04  1.500079e-04  1.573944e-04  1.651496e-04
## ASV1611     -5.176100e-04 -5.409564e-04 -5.652944e-04 -5.906607e-04
## ASV0227     -1.841502e-04 -1.926101e-04 -2.014432e-04 -2.106646e-04
## ASV0833      2.055528e-04  2.153366e-04  2.255820e-04  2.363102e-04
## ASV0718      4.903555e-04  5.127484e-04  5.361201e-04  5.605096e-04
## ASV1139      1.827342e-04  1.907764e-04  1.991422e-04  2.078422e-04
## ASV0766     -1.294213e-04 -1.349825e-04 -1.407540e-04 -1.467413e-04
## ASV2091      6.403898e-04  6.680962e-04  6.968802e-04  7.267734e-04
## ASV1238     -3.011519e-05 -3.065859e-05 -3.115761e-05 -3.160539e-05
## ASV9193     -7.383082e-05 -7.808091e-05 -8.258562e-05 -8.735984e-05
## ASV0290     -5.009374e-05 -5.236539e-05 -5.473346e-05 -5.720134e-05
## ASV0231      5.076424e-04  5.300619e-04  5.533915e-04  5.776611e-04
## ASV0185      1.040761e-04  1.103956e-04  1.171292e-04  1.243047e-04
## ASV2330      1.474956e-04  1.539618e-04  1.606874e-04  1.676806e-04
## ASV3119     -1.735659e-04 -1.820392e-04 -1.909295e-04 -2.002571e-04
## ASV2368     -2.386791e-04 -2.498476e-04 -2.615269e-04 -2.737390e-04
## ASV0122     -1.858471e-04 -1.940377e-04 -2.025633e-04 -2.114357e-04
## ASV1044      3.296795e-04  3.454320e-04  3.619366e-04  3.792288e-04
## ASV0160     -4.478390e-04 -4.668811e-04 -4.866327e-04 -5.071120e-04
## ASV0326      2.940936e-04  3.073236e-04  3.211134e-04  3.354837e-04
## ASV1388      5.141002e-04  5.370578e-04  5.609726e-04  5.858787e-04
## ASV0792      5.895348e-04  6.158985e-04  6.433636e-04  6.719690e-04
## ASV0036     -3.748288e-04 -3.921773e-04 -4.103056e-04 -4.292467e-04
## ASV2125      6.056789e-04  6.329296e-04  6.613357e-04  6.909399e-04
## ASV1075      1.164616e-04  1.219160e-04  1.276234e-04  1.335952e-04
## ASV0390      1.222308e-04  1.285312e-04  1.351725e-04  1.421742e-04
## ASV3790     -4.732294e-04 -4.941128e-04 -5.158435e-04 -5.384494e-04
## ASV1535     -4.099625e-05 -4.300971e-05 -4.512010e-05 -4.733160e-05
## ASV0263      1.040538e-04  1.089255e-04  1.140201e-04  1.193471e-04
## ASV0675      8.081427e-04  8.456989e-04  8.849521e-04  9.259742e-04
## ASV3348      7.932490e-05  8.321437e-05  8.729854e-05  9.158734e-05
## ASV0058     -7.547377e-04 -7.881890e-04 -8.230144e-04 -8.592614e-04
## ASV4142      1.854230e-04  1.934477e-04  2.017850e-04  2.104440e-04
## ASV0059     -6.502566e-04 -6.790015e-04 -7.089207e-04 -7.400540e-04
## ASV0013     -1.364953e-03 -1.425903e-03 -1.489396e-03 -1.555523e-03
## ASV0033     -4.091278e-04 -4.281391e-04 -4.480115e-04 -4.687818e-04
## ASV4354     -1.751582e-04 -1.828329e-04 -1.908136e-04 -1.991099e-04
## ASV0022     -4.319374e-04 -4.519891e-04 -4.729471e-04 -4.948500e-04
## ASV0134     -1.112862e-04 -1.168174e-04 -1.226313e-04 -1.287428e-04
## ASV0415     -8.622878e-05 -8.955506e-05 -9.297505e-05 -9.648840e-05
## ASV10103    -2.978222e-04 -3.113359e-04 -3.254307e-04 -3.401289e-04
## ASV1613      4.834340e-04  5.050247e-04  5.275168e-04  5.509426e-04
## ASV0135     -2.813572e-05 -2.894883e-05 -2.975438e-05 -3.054821e-05
## ASV0469     -5.997591e-04 -6.262946e-04 -6.539138e-04 -6.826532e-04
## ASV0471      3.887391e-04  4.066107e-04  4.252705e-04  4.447498e-04
## ASV0451     -1.048943e-04 -1.099286e-04 -1.152065e-04 -1.207399e-04
## ASV0747      1.444749e-04  1.510892e-04  1.579919e-04  1.651940e-04
## ASV1314     -2.315041e-04 -2.424958e-04 -2.540040e-04 -2.660522e-04
## ASV0425     -6.752572e-04 -7.045872e-04 -7.350679e-04 -7.667341e-04
## ASV0559     -3.794568e-04 -3.956799e-04 -4.125156e-04 -4.299802e-04
## ASV0148     -4.151776e-04 -4.330719e-04 -4.516560e-04 -4.709495e-04
## ASV0129     -2.047385e-04 -2.131944e-04 -2.219446e-04 -2.309948e-04
## ASV1072      1.992082e-04  2.076489e-04  2.164032e-04  2.254793e-04
## ASV2390      1.456997e-04  1.520308e-04  1.586098e-04  1.654440e-04
## ASV0548      4.428096e-04  4.630524e-04  4.841838e-04  5.062397e-04
## ASV0168     -6.534228e-04 -6.821086e-04 -7.119484e-04 -7.429799e-04
## ASV0066     -4.921475e-04 -5.142158e-04 -5.372133e-04 -5.611741e-04
## ASV0468     -1.898296e-04 -1.987752e-04 -2.081367e-04 -2.179328e-04
## ASV0172     -9.910610e-05 -1.028432e-04 -1.066773e-04 -1.106071e-04
## ASV0236     -2.463354e-04 -2.562414e-04 -2.664651e-04 -2.770098e-04
## ASV0250      2.109034e-05  2.326577e-05  2.563918e-05  2.822666e-05
## ASV0338     -2.397040e-05 -2.402736e-05 -2.399966e-05 -2.387717e-05
## ASV0450      1.884299e-06  2.168669e-06  2.482828e-06  2.829432e-06
## ASV0377      5.418877e-04  5.663671e-04  5.918922e-04  6.185024e-04
## ASV1022      1.548040e-04  1.620283e-04  1.695822e-04  1.774802e-04
## ASV6174     -3.313851e-05 -3.437465e-05 -3.563884e-05 -3.692979e-05
## ASV0786      6.152919e-05  6.419564e-05  6.696510e-05  6.984042e-05
## ASV0053     -6.504178e-04 -6.798147e-04 -7.104697e-04 -7.424305e-04
## ASV0697     -1.855389e-04 -1.934659e-04 -2.016930e-04 -2.102283e-04
## ASV0785      4.833170e-04  5.051369e-04  5.278924e-04  5.516195e-04
## ASV1967     -3.212167e-04 -3.353543e-04 -3.500622e-04 -3.653590e-04
## ASV0385     -1.447294e-04 -1.507901e-04 -1.570723e-04 -1.635819e-04
## ASV0295      1.904308e-06  2.490682e-06  3.146450e-06  3.878063e-06
## ASV0072     -5.134290e-04 -5.358395e-04 -5.591414e-04 -5.833628e-04
## ASV0157     -2.062177e-04 -2.146197e-04 -2.232966e-04 -2.322511e-04
## ASV0501      2.417959e-04  2.532133e-04  2.651560e-04  2.776463e-04
## ASV10729    -3.987844e-04 -4.170140e-04 -4.360399e-04 -4.558934e-04
## ASV1470      1.741702e-04  1.812701e-04  1.886091e-04  1.961910e-04
## ASV0050     -1.286901e-03 -1.344016e-03 -1.403482e-03 -1.465380e-03
## ASV0411     -3.494043e-05 -3.639818e-05 -3.791140e-05 -3.948207e-05
## ASV0549      2.489915e-04  2.606867e-04  2.729249e-04  2.857308e-04
## ASV0184      1.530539e-04  1.600118e-04  1.672709e-04  1.748432e-04
## ASV0705      1.877384e-04  1.965865e-04  2.058440e-04  2.155288e-04
## ASV1715      4.596922e-04  4.804628e-04  5.021220e-04  5.247034e-04
## ASV0603      5.982190e-05  6.283723e-05  6.601019e-05  6.934938e-05
## ASV0826      1.523731e-04  1.589587e-04  1.657992e-04  1.729020e-04
## ASV0034     -5.844027e-04 -6.102567e-04 -6.371651e-04 -6.651631e-04
## ASV0838      1.403364e-04  1.473279e-04  1.546719e-04  1.623858e-04
## ASV0614     -3.401582e-04 -3.556380e-04 -3.717896e-04 -3.886396e-04
## ASV0014     -1.248581e-03 -1.304094e-03 -1.361902e-03 -1.422084e-03
## ASV0585     -7.145607e-05 -7.438880e-05 -7.742158e-05 -8.055611e-05
## ASV0016     -1.276963e-03 -1.333790e-03 -1.392971e-03 -1.454587e-03
## ASV5394     -3.302848e-04 -3.454449e-04 -3.612730e-04 -3.777961e-04
## ASV0666      2.779536e-04  2.904173e-04  3.034042e-04  3.169328e-04
## ASV2085      1.066065e-04  1.107426e-04  1.149963e-04  1.193668e-04
## ASV0003     -1.167424e-03 -1.219245e-03 -1.273202e-03 -1.329366e-03
## ASV0346     -1.716780e-05 -1.715111e-05 -1.706457e-05 -1.689973e-05
## ASV0267     -1.895362e-04 -1.978857e-04 -2.065730e-04 -2.156092e-04
## ASV0353      2.584623e-04  2.709658e-04  2.840717e-04  2.978080e-04
## ASV2419      3.312260e-04  3.459316e-04  3.612433e-04  3.771819e-04
## ASV0447      1.614452e-04  1.695107e-04  1.779881e-04  1.868983e-04
## ASV0654      5.112155e-04  5.343629e-04  5.585021e-04  5.836705e-04
## ASV0151      8.157401e-05  8.572332e-05  9.009299e-05  9.469533e-05
## ASV0065     -4.720418e-04 -4.931159e-04 -5.150707e-04 -5.379380e-04
## ASV0527      3.466297e-04  3.623402e-04  3.787268e-04  3.958156e-04
## ASV4055     -1.383376e-04 -1.452212e-04 -1.524572e-04 -1.600643e-04
## ASV0166     -3.802986e-04 -3.963763e-04 -4.130462e-04 -4.303226e-04
## ASV0417     -3.309910e-04 -3.455842e-04 -3.607691e-04 -3.765652e-04
## ASV0078     -2.644897e-04 -2.759955e-04 -2.879558e-04 -3.003847e-04
## ASV0322     -3.150153e-04 -3.283956e-04 -3.422753e-04 -3.566674e-04
## ASV0156     -4.080504e-04 -4.254892e-04 -4.435879e-04 -4.623645e-04
## ASV0648     -3.869138e-04 -4.047593e-04 -4.233985e-04 -4.428639e-04
## ASV0407      2.068143e-05  2.138179e-05  2.209251e-05  2.281240e-05
## ASV2030     -7.891595e-05 -8.210709e-05 -8.540107e-05 -8.879884e-05
## ASV0300      2.336165e-04  2.450030e-04  2.569477e-04  2.694776e-04
## ASV1150     -3.253992e-05 -3.400585e-05 -3.553359e-05 -3.712534e-05
## ASV0958      2.388439e-04  2.502970e-04  2.623000e-04  2.748792e-04
## ASV0216     -4.034685e-04 -4.212029e-04 -4.396496e-04 -4.588314e-04
## ASV0446      5.668248e-04  5.932979e-04  6.209770e-04  6.499139e-04
## ASV0367     -1.909759e-04 -1.994862e-04 -2.083500e-04 -2.175798e-04
## ASV0200     -3.498988e-04 -3.653561e-04 -3.814469e-04 -3.981932e-04
## ASV0334     -1.727107e-04 -1.792502e-04 -1.859580e-04 -1.928311e-04
## ASV1311      2.611778e-04  2.732419e-04  2.858467e-04  2.990150e-04
## ASV0458      2.728857e-04  2.851066e-04  2.978407e-04  3.111069e-04
## ASV1371      3.571739e-06  3.536804e-06  3.482451e-06  3.406319e-06
## ASV0418      3.188499e-04  3.325930e-04  3.468662e-04  3.616848e-04
## ASV0004      3.899220e-04  4.072084e-04  4.252050e-04  4.439359e-04
## ASV1943      2.855876e-04  2.980968e-04  3.111066e-04  3.246333e-04
## ASV1495     -7.279023e-05 -7.651322e-05 -8.043389e-05 -8.456303e-05
## ASV0901     -4.542847e-04 -4.752740e-04 -4.972033e-04 -5.201119e-04
## ASV0628      2.657135e-04  2.776045e-04  2.899945e-04  3.029015e-04
## ASV0400      1.038343e-04  1.083383e-04  1.130157e-04  1.178713e-04
## ASV0116     -3.374160e-04 -3.526086e-04 -3.684465e-04 -3.849537e-04
## ASV0788      2.837693e-04  2.964948e-04  3.097557e-04  3.235714e-04
## ASV0117      1.847618e-04  1.934519e-04  2.025452e-04  2.120597e-04
## ASV3137      5.077713e-05  5.305840e-05  5.543730e-05  5.791774e-05
## ASV0001      4.749460e-04  4.958999e-04  5.177073e-04  5.403970e-04
## ASV1651      3.012920e-04  3.138406e-04  3.268315e-04  3.402733e-04
## ASV1692      3.419523e-04  3.579351e-04  3.746488e-04  3.921250e-04
## ASV0660      1.911035e-04  1.991914e-04  2.075733e-04  2.162554e-04
## ASV0508      2.533160e-05  2.638541e-05  2.747579e-05  2.860331e-05
## ASV1660     -1.381544e-04 -1.445905e-04 -1.513175e-04 -1.583473e-04
## ASV0233      7.817455e-05  8.190288e-05  8.580978e-05  8.990390e-05
## ASV1343     -3.404049e-04 -3.558759e-04 -3.720156e-04 -3.888498e-04
## ASV0209      3.197124e-04  3.339546e-04  3.487895e-04  3.642382e-04
## ASV0193     -3.945904e-04 -4.113881e-04 -4.288160e-04 -4.468908e-04
## ASV0357     -3.059327e-05 -3.191726e-05 -3.329004e-05 -3.471241e-05
## ASV0198      9.254232e-05  9.696606e-05  1.015989e-04  1.064504e-04
## ASV0007      4.512299e-04  4.711843e-04  4.919557e-04  5.135724e-04
## ASV1772     -4.425218e-05 -4.613030e-05 -4.807741e-05 -5.009505e-05
## ASV0009      4.261419e-04  4.449810e-04  4.645912e-04  4.849991e-04
## ASV0006      1.694851e-04  1.765904e-04  1.839521e-04  1.915761e-04
## ASV0011     -4.769450e-04 -4.987623e-04 -5.215347e-04 -5.453000e-04
## ASV0015      3.289050e-04  3.435602e-04  3.588239e-04  3.747175e-04
## ASV0017      3.482247e-04  3.637156e-04  3.798478e-04  3.966439e-04
## ASV0235     -2.748621e-04 -2.872338e-04 -3.001271e-04 -3.135607e-04
## ASV0382      5.620156e-05  5.950041e-05  6.300536e-05  6.672954e-05
## ASV2357      4.190176e-04  4.378678e-04  4.575157e-04  4.779905e-04
## ASV0567     -3.059014e-04 -3.195259e-04 -3.337173e-04 -3.484959e-04
## ASV0165      3.375495e-04  3.528330e-04  3.687711e-04  3.853882e-04
## ASV0005      6.655995e-04  6.948465e-04  7.252709e-04  7.569110e-04
## ASV0384     -3.515528e-05 -3.660474e-05 -3.810395e-05 -3.965374e-05
## ASV0002      1.419429e-04  1.484411e-04  1.552242e-04  1.623034e-04
## ASV3017      3.898256e-04  4.069212e-04  4.247021e-04  4.431901e-04
## ASV0091      1.507692e-04  1.576563e-04  1.648432e-04  1.723416e-04
## ASV0186     -4.007172e-04 -4.186313e-04 -4.372929e-04 -4.567284e-04
## ASV0370      4.464285e-05  4.690114e-05  4.927903e-05  5.178327e-05
## ASV0018      6.936797e-04  7.242358e-04  7.560288e-04  7.890997e-04
## ASV1377      6.099521e-04  6.369237e-04  6.649943e-04  6.942005e-04
## ASV0019      6.946782e-04  7.252889e-04  7.571399e-04  7.902720e-04
## ASV0023      4.795071e-05  4.960300e-05  5.128193e-05  5.298492e-05
## ASV2194      2.249318e-04  2.350744e-04  2.456524e-04  2.566830e-04
## ASV1155     -1.961116e-05 -1.999429e-05 -2.034935e-05 -2.067145e-05
## ASV0510     -2.470542e-04 -2.571255e-04 -2.675340e-04 -2.782847e-04
## ASV2371     -2.509283e-04 -2.617003e-04 -2.728824e-04 -2.844857e-04
## ASV0024      1.426626e-05  1.440259e-05  1.450124e-05  1.455722e-05
## ASV2452      3.287247e-04  3.431048e-04  3.580587e-04  3.736046e-04
## ASV2332      6.095954e-06  6.372481e-06  6.663135e-06  6.968904e-06
## ASV2591      1.515945e-05  1.630619e-05  1.754249e-05  1.887513e-05
## ASV0521      4.635306e-04  4.853190e-04  5.081122e-04  5.319544e-04
## ASV5542      1.384668e-04  1.448765e-04  1.515733e-04  1.585694e-04
## ASV0336     -2.004297e-04 -2.089100e-04 -2.177037e-04 -2.268184e-04
## ASV10102     3.109415e-04  3.249890e-04  3.396351e-04  3.549021e-04
## ASV16823    -2.459238e-04 -2.565525e-04 -2.675926e-04 -2.790559e-04
## ASV3104      2.459010e-04  2.565277e-04  2.675656e-04  2.790267e-04
## ASV0781      1.233589e-04  1.290681e-04  1.350339e-04  1.412672e-04
## ASV10899     1.151201e-04  1.207508e-04  1.266601e-04  1.328617e-04
## ASV11222    -2.458861e-04 -2.565116e-04 -2.675482e-04 -2.790078e-04
## ASV11327    -2.458633e-04 -2.564868e-04 -2.675213e-04 -2.789785e-04
## ASV12458    -2.458406e-04 -2.564621e-04 -2.674944e-04 -2.789493e-04
## ASV1636     -1.986610e-04 -2.071127e-04 -2.158790e-04 -2.249679e-04
## ASV1890     -2.443605e-04 -2.549733e-04 -2.660018e-04 -2.774582e-04
## ASV2898      5.318561e-04  5.555980e-04  5.803284e-04  6.060822e-04
## ASV8328     -3.869250e-05 -3.980945e-05 -4.091832e-05 -4.201404e-05
## ASV0709     -4.303785e-04 -4.494478e-04 -4.692984e-04 -4.899568e-04
## ASV0856      7.324832e-05  7.692030e-05  8.078240e-05  8.484479e-05
## ASV0909     -1.772514e-04 -1.843651e-04 -1.917043e-04 -1.992709e-04
## ASV0937     -3.375761e-04 -3.528031e-04 -3.686786e-04 -3.852269e-04
## ASV11390    -2.457925e-04 -2.564099e-04 -2.674377e-04 -2.788878e-04
## ASV11966     1.217007e-04  1.272735e-04  1.330898e-04  1.391590e-04
## ASV12990     6.883681e-05  7.208100e-05  7.547582e-05  7.902800e-05
## ASV14797     2.550576e-04  2.663267e-04  2.780548e-04  2.902570e-04
## ASV14904    -2.457862e-04 -2.564031e-04 -2.674304e-04 -2.788799e-04
## ASV15304     6.304289e-05  6.605110e-05  6.920088e-05  7.249852e-05
## ASV16696    -2.457672e-04 -2.563824e-04 -2.674080e-04 -2.788556e-04
## ASV1690      1.273162e-04  1.334042e-04  1.397811e-04  1.464600e-04
## ASV2029      6.807479e-04  7.111768e-04  7.428758e-04  7.758899e-04
## ASV2834      3.604772e-04  3.765319e-04  3.932507e-04  4.106565e-04
## ASV4003      1.087754e-04  1.143553e-04  1.202343e-04  1.264289e-04
## ASV4064      2.484746e-04  2.595238e-04  2.710286e-04  2.830045e-04
## ASV4294      9.355181e-05  9.837537e-05  1.034598e-04  1.088198e-04
## ASV4609     -1.211425e-05 -1.261562e-05 -1.313350e-05 -1.366797e-05
## ASV6283     -2.457648e-04 -2.563801e-04 -2.674057e-04 -2.788535e-04
## ASV6491     -2.457421e-04 -2.563553e-04 -2.673788e-04 -2.788243e-04
## ASV7453      1.001033e-04  1.051042e-04  1.103602e-04  1.158841e-04
## ASV7959      1.832358e-05  1.947353e-05  2.070042e-05  2.200941e-05
## ASV8219      2.457264e-04  2.563384e-04  2.673605e-04  2.788046e-04
## ASV8547     -2.457037e-04 -2.563137e-04 -2.673337e-04 -2.787754e-04
## ASV9319      1.629486e-04  1.702762e-04  1.779127e-04  1.858695e-04
## ASV9382     -2.456895e-04 -2.562983e-04 -2.673170e-04 -2.787572e-04
## ASV11516    -2.456667e-04 -2.562736e-04 -2.672901e-04 -2.787280e-04
## ASV14377    -2.456440e-04 -2.562489e-04 -2.672632e-04 -2.786989e-04
## ASV1867      3.629077e-04  3.795343e-04  3.968921e-04  4.150103e-04
## ASV1895     -8.417493e-05 -8.779950e-05 -9.156379e-05 -9.547185e-05
## ASV3168      1.514115e-04  1.580310e-04  1.649132e-04  1.720662e-04
## ASV4449      3.062638e-04  3.196810e-04  3.336344e-04  3.481412e-04
## ASV6596      1.839117e-04  1.929668e-04  2.024778e-04  2.124682e-04
## ASV7492     -9.100506e-05 -9.459738e-05 -9.829753e-05 -1.021057e-04
## ASV9854     -1.254434e-04 -1.307258e-04 -1.361998e-04 -1.418697e-04
## ASV6296      2.455967e-04  2.561975e-04  2.672076e-04  2.786386e-04
## ASV4201      8.339265e-05  8.780893e-05  9.247174e-05  9.739541e-05
## ASV0552      6.086601e-04  6.366180e-04  6.658095e-04  6.962842e-04
## ASV3671     -4.661938e-05 -4.817618e-05 -4.975019e-05 -5.133773e-05
## ASV3529     -5.512660e-05 -5.720703e-05 -5.934083e-05 -6.152707e-05
## ASV1060      1.558375e-04  1.631561e-04  1.708142e-04  1.788272e-04
## ASV0239     -3.326478e-04 -3.466357e-04 -3.611290e-04 -3.761386e-04
## ASV5711     -3.137004e-04 -3.273345e-04 -3.415034e-04 -3.562233e-04
## ASV4152     -4.127393e-04 -4.308565e-04 -4.497004e-04 -4.692941e-04
## ASV1461      3.692956e-04  3.853362e-04  4.020055e-04  4.193222e-04
## ASV2877      2.997573e-04  3.129608e-04  3.266979e-04  3.409861e-04
## ASV0012      2.260182e-04  2.363647e-04  2.471644e-04  2.584354e-04
## ASV9823      6.802383e-05  7.033065e-05  7.267364e-05  7.504947e-05
## ASV0008      2.466502e-04  2.578673e-04  2.695698e-04  2.817762e-04
## ASV7832     -2.573847e-04 -2.687524e-04 -2.805824e-04 -2.928901e-04
## ASV1915      2.121152e-05  2.240343e-05  2.366602e-05  2.500350e-05
## ASV0055      1.768086e-04  1.847341e-04  1.929921e-04  2.015945e-04
## ASV0032      4.344675e-04  4.540179e-04  4.743979e-04  4.956386e-04
## ASV2977     -3.479616e-04 -3.632452e-04 -3.791426e-04 -3.956733e-04
## ASV0466      3.492394e-04  3.642394e-04  3.798114e-04  3.959708e-04
## ASV3866      3.782417e-04  3.955422e-04  4.136007e-04  4.324472e-04
## ASV0040      4.952809e-04  5.177130e-04  5.411067e-04  5.654985e-04
## ASV0496     -3.077577e-05 -3.272526e-05 -3.480798e-05 -3.703330e-05
## ASV0052      6.025607e-04  6.292432e-04  6.570173e-04  6.859200e-04
## ASV3828     -3.772188e-04 -3.940757e-04 -4.116378e-04 -4.299305e-04
## ASV1930      2.365186e-04  2.473258e-04  2.586039e-04  2.703713e-04
## ASV2126      3.805961e-04  3.977123e-04  4.155534e-04  4.341461e-04
## ASV0793      2.232673e-04  2.335187e-04  2.442238e-04  2.554012e-04
## ASV0299     -1.555773e-04 -1.619780e-04 -1.685951e-04 -1.754319e-04
## ASV0208      3.649762e-04  3.822476e-04  4.003264e-04  4.192492e-04
## ASV0511     -1.871806e-04 -1.948383e-04 -2.027524e-04 -2.109267e-04
## ASV1123     -2.461504e-04 -2.564527e-04 -2.671232e-04 -2.781695e-04
## ASV0099     -1.320206e-04 -1.375220e-04 -1.432172e-04 -1.491099e-04
## ASV0752     -3.079659e-05 -3.248863e-05 -3.428006e-05 -3.617705e-05
## ASV0883      1.869112e-06  1.998008e-06  2.136981e-06  2.286901e-06
## ASV0683      3.232138e-04  3.383889e-04  3.542649e-04  3.708728e-04
## ASV4117     -3.712380e-04 -3.874464e-04 -4.042968e-04 -4.218088e-04
## ASV2172      1.396209e-04  1.458993e-04  1.524442e-04  1.592657e-04
## ASV0330     -2.566154e-04 -2.683156e-04 -2.805282e-04 -2.932738e-04
## ASV0728      2.282164e-04  2.381307e-04  2.484355e-04  2.591429e-04
## ASV0499      4.889446e-04  5.119295e-04  5.359779e-04  5.611369e-04
## ASV0120     -5.277973e-04 -5.514014e-04 -5.759904e-04 -6.015991e-04
## ASV1446      4.294616e-05  4.451250e-05  4.611202e-05  4.774299e-05
## ASV17171    -3.587000e-04 -3.746957e-04 -3.913560e-04 -4.087043e-04
## ASV0533      1.039178e-04  1.088461e-04  1.140051e-04  1.194052e-04
## ASV2495     -1.439394e-04 -1.504563e-04 -1.572533e-04 -1.643411e-04
## ASV5582      1.227473e-04  1.278507e-04  1.331342e-04  1.386016e-04
## ASV1488      1.300470e-04  1.366506e-04  1.435945e-04  1.508958e-04
## ASV0682      3.410528e-04  3.570942e-04  3.738772e-04  3.914343e-04
## ASV0068     -1.985500e-05 -2.104284e-05 -2.230618e-05 -2.364985e-05
## ASV1987     -1.809329e-04 -1.895117e-04 -1.984929e-04 -2.078948e-04
## ASV0035      6.111423e-05  6.328276e-05  6.548978e-05  6.773182e-05
## ASV7192     -2.367356e-04 -2.468528e-04 -2.573504e-04 -2.682383e-04
## ASV0873      3.455454e-05  3.578331e-05  3.703609e-05  3.831148e-05
## ASV4749      2.095915e-05  2.145505e-05  2.193195e-05  2.238566e-05
## ASV2174      2.151588e-04  2.238930e-04  2.329200e-04  2.422448e-04
## ASV1476     -1.957095e-04 -2.043831e-04 -2.134128e-04 -2.228108e-04
## ASV0740     -4.888445e-04 -5.114743e-04 -5.351198e-04 -5.598236e-04
## ASV0170      1.035995e-04  1.082991e-04  1.132022e-04  1.183167e-04
## ASV2466     -4.431635e-04 -4.632017e-04 -4.840989e-04 -5.058879e-04
## ASV1709      3.400495e-04  3.551372e-04  3.708457e-04  3.871964e-04
## ASV6170     -2.853991e-04 -2.971817e-04 -3.093791e-04 -3.220008e-04
## ASV3673      3.447318e-04  3.598181e-04  3.755125e-04  3.918354e-04
## ASV1745      2.038299e-05  2.104513e-05  2.171684e-05  2.239737e-05
## ASV0380     -2.269439e-04 -2.361172e-04 -2.455972e-04 -2.553894e-04
## ASV0426     -6.818015e-05 -7.075475e-05 -7.339544e-05 -7.610099e-05
## ASV0202     -6.622592e-05 -6.815538e-05 -7.007317e-05 -7.197076e-05
## ASV6350     -2.874372e-04 -2.994880e-04 -3.119817e-04 -3.249301e-04
## ASV0713     -2.075373e-04 -2.167474e-04 -2.263386e-04 -2.363245e-04
## ASV1822      4.191307e-05  4.394127e-05  4.606417e-05  4.828555e-05
## ASV4569      3.350918e-04  3.498350e-04  3.651772e-04  3.811387e-04
## ASV0030     -7.641593e-05 -8.010906e-05 -8.397928e-05 -8.803465e-05
## ASV0331      1.424084e-04  1.493718e-04  1.566810e-04  1.643534e-04
## ASV2981      3.439432e-04  3.598500e-04  3.764655e-04  3.938185e-04
## ASV0828     -2.301592e-04 -2.409693e-04 -2.522759e-04 -2.641003e-04
## ASV2440      5.445496e-04  5.697766e-04  5.961357e-04  6.236740e-04
## ASV3006     -2.304065e-04 -2.397494e-04 -2.494076e-04 -2.593871e-04
## ASV3875     -2.303866e-04 -2.397280e-04 -2.493844e-04 -2.593621e-04
## ASV4511      1.377665e-04  1.443300e-04  1.512041e-04  1.584028e-04
## ASV4700     -2.303670e-04 -2.397067e-04 -2.493615e-04 -2.593372e-04
## ASV5804     -2.303472e-04 -2.396853e-04 -2.493383e-04 -2.593122e-04
## ASV6826      2.532586e-04  2.651837e-04  2.776623e-04  2.907190e-04
## ASV7280      2.086733e-04  2.183400e-04  2.284345e-04  2.389736e-04
## ASV7535     -2.303373e-04 -2.396747e-04 -2.493270e-04 -2.593002e-04
## ASV0651     -2.419251e-04 -2.524780e-04 -2.634469e-04 -2.748441e-04
## ASV0913      3.303991e-04  3.458242e-04  3.619553e-04  3.788234e-04
## ASV10832    -2.303185e-04 -2.396544e-04 -2.493050e-04 -2.592764e-04
## ASV1117     -4.638473e-04 -4.843378e-04 -5.056663e-04 -5.278615e-04
## ASV11329     1.188435e-04  1.251779e-04  1.318647e-04  1.389239e-04
## ASV13209    -1.077028e-05 -1.045556e-05 -1.006558e-05 -9.593342e-06
## ASV1345      5.790483e-05  6.066545e-05  6.355107e-05  6.656629e-05
## ASV1719     -2.302883e-04 -2.396218e-04 -2.492700e-04 -2.592388e-04
## ASV1886      2.680298e-04  2.799512e-04  2.923710e-04  3.053076e-04
## ASV2158     -6.074219e-05 -6.275258e-05 -6.479368e-05 -6.686309e-05
## ASV2189      2.880630e-04  3.011110e-04  3.147209e-04  3.289144e-04
## ASV2257      2.110736e-04  2.203389e-04  2.299800e-04  2.400098e-04
## ASV2283      2.302442e-04  2.395740e-04  2.492183e-04  2.591827e-04
## ASV2328      2.302244e-04  2.395526e-04  2.491951e-04  2.591577e-04
## ASV2434     -3.443189e-04 -3.591938e-04 -3.746519e-04 -3.907117e-04
## ASV2648      2.301810e-04  2.395056e-04  2.491441e-04  2.591025e-04
## ASV2698      3.388063e-04  3.543233e-04  3.705246e-04  3.874385e-04
## ASV2775      3.993596e-04  4.163615e-04  4.340021e-04  4.522986e-04
## ASV3171      2.301396e-04  2.394607e-04  2.490954e-04  2.590497e-04
## ASV3227      2.941649e-04  3.065198e-04  3.193237e-04  3.325870e-04
## ASV3397      1.833585e-05  1.922638e-05  2.015544e-05  2.112389e-05
## ASV3444      3.324480e-04  3.466525e-04  3.614009e-04  3.767093e-04
## ASV3556      2.300879e-04  2.394047e-04  2.490348e-04  2.589841e-04
## ASV3606     -2.300682e-04 -2.393833e-04 -2.490117e-04 -2.589591e-04
## ASV4190      2.968856e-04  3.103139e-04  3.243192e-04  3.389238e-04
## ASV4197      3.388615e-04  3.531934e-04  3.680576e-04  3.834679e-04
## ASV4722      3.081434e-04  3.217987e-04  3.360155e-04  3.508135e-04
## ASV4765      7.904696e-05  8.283041e-05  8.678946e-05  9.093133e-05
## ASV4809      2.300191e-04  2.393301e-04  2.489540e-04  2.588967e-04
## ASV4846      2.207164e-04  2.308289e-04  2.413834e-04  2.523969e-04
## ASV4903     -5.724870e-05 -5.895465e-05 -6.066501e-05 -6.237525e-05
## ASV4944     -2.299999e-04 -2.393095e-04 -2.489319e-04 -2.588730e-04
## ASV5151     -9.071453e-05 -9.549381e-05 -1.005311e-04 -1.058398e-04
## ASV5413     -2.299856e-04 -2.392941e-04 -2.489154e-04 -2.588553e-04
## ASV5537     -2.299659e-04 -2.392728e-04 -2.488924e-04 -2.588304e-04
## ASV5688      2.299461e-04  2.392514e-04  2.488693e-04  2.588055e-04
## ASV5752      1.115331e-04  1.168005e-04  1.223068e-04  1.280614e-04
## ASV6122     -2.299316e-04 -2.392358e-04 -2.488524e-04 -2.587873e-04
## ASV6135      2.299118e-04  2.392144e-04  2.488293e-04  2.587624e-04
## ASV6188     -2.298921e-04 -2.391931e-04 -2.488063e-04 -2.587375e-04
## ASV6216      3.424734e-04  3.571425e-04  3.723746e-04  3.881863e-04
## ASV6242      2.298501e-04  2.391475e-04  2.487569e-04  2.586840e-04
## ASV6383      2.298303e-04  2.391262e-04  2.487339e-04  2.586591e-04
## ASV6781      2.298106e-04  2.391049e-04  2.487108e-04  2.586342e-04
## ASV6799     -2.297909e-04 -2.390835e-04 -2.486878e-04 -2.586093e-04
## ASV7374     -2.297712e-04 -2.390622e-04 -2.486647e-04 -2.585845e-04
## ASV7539     -2.297515e-04 -2.390409e-04 -2.486417e-04 -2.585596e-04
## ASV8591     -2.297318e-04 -2.390196e-04 -2.486187e-04 -2.585347e-04
## ASV8637      2.297120e-04  2.389983e-04  2.485956e-04  2.585098e-04
## ASV12796    -2.296923e-04 -2.389770e-04 -2.485726e-04 -2.584850e-04
## ASV1934      2.701629e-04  2.825076e-04  2.953927e-04  3.088398e-04
## ASV22549     1.800037e-05  1.963998e-05  2.141452e-05  2.333361e-05
## ASV29857    -2.296738e-04 -2.389570e-04 -2.485511e-04 -2.584619e-04
## ASV3215      3.291888e-04  3.444312e-04  3.603591e-04  3.770014e-04
## ASV3236     -2.296527e-04 -2.389342e-04 -2.485265e-04 -2.584353e-04
## ASV3954     -2.296330e-04 -2.389129e-04 -2.485035e-04 -2.584104e-04
## ASV4850      2.296133e-04  2.388916e-04  2.484805e-04  2.583856e-04
## ASV5225      2.295936e-04  2.388703e-04  2.484575e-04  2.583607e-04
## ASV5532     -2.295740e-04 -2.388490e-04 -2.484345e-04 -2.583359e-04
## ASV7258      3.264265e-05  3.524866e-05  3.805994e-05  4.109157e-05
## ASV9474     -1.297702e-04 -1.346385e-04 -1.396377e-04 -1.447676e-04
## ASV11857    -2.295482e-04 -2.388214e-04 -2.484049e-04 -2.583042e-04
## ASV1202     -2.295285e-04 -2.388001e-04 -2.483819e-04 -2.582794e-04
## ASV14742     1.682582e-04  1.765810e-04  1.853203e-04  1.944965e-04
## ASV16652     8.518832e-05  8.931680e-05  9.364018e-05  9.816660e-05
## ASV2019      3.394897e-04  3.541893e-04  3.694661e-04  3.853382e-04
## ASV2410     -3.172931e-04 -3.314733e-04 -3.462489e-04 -3.616422e-04
## ASV2718      3.408990e-04  3.568937e-04  3.736205e-04  3.911105e-04
## ASV2738      3.794561e-04  3.955116e-04  4.121619e-04  4.294221e-04
## ASV2876      2.294855e-04  2.387537e-04  2.483318e-04  2.582253e-04
## ASV3177      2.294659e-04  2.387324e-04  2.483088e-04  2.582005e-04
## ASV4367      2.294462e-04  2.387112e-04  2.482858e-04  2.581757e-04
## ASV4635      8.322170e-05  8.789505e-05  9.283980e-05  9.807119e-05
## ASV4896      2.412192e-05  2.640136e-05  2.887737e-05  3.156520e-05
## ASV4907      1.741010e-04  1.828178e-04  1.919771e-04  2.016007e-04
## ASV5230     -2.294471e-04 -2.387126e-04 -2.482880e-04 -2.581787e-04
## ASV6509     -2.294274e-04 -2.386914e-04 -2.482650e-04 -2.581539e-04
## ASV7376     -2.294077e-04 -2.386701e-04 -2.482420e-04 -2.581291e-04
## ASV8163     -2.293881e-04 -2.386489e-04 -2.482191e-04 -2.581043e-04
## ASV8195     -2.293684e-04 -2.386276e-04 -2.481961e-04 -2.580795e-04
## ASV8923      1.442144e-04  1.512258e-04  1.585754e-04  1.662784e-04
## ASV9666     -2.029804e-04 -2.110418e-04 -2.193609e-04 -2.279412e-04
## ASV1482      2.105848e-04  2.201365e-04  2.300965e-04  2.404795e-04
## ASV2726      2.792703e-04  2.923066e-04  3.059330e-04  3.201741e-04
## ASV3281     -2.293478e-04 -2.386055e-04 -2.481725e-04 -2.580543e-04
## ASV4235     -2.293281e-04 -2.385843e-04 -2.481495e-04 -2.580295e-04
## ASV4808      3.411074e-04  3.556612e-04  3.707678e-04  3.864426e-04
## ASV4861     -3.437191e-04 -3.585432e-04 -3.739469e-04 -3.899484e-04
## ASV5276      3.363173e-04  3.506001e-04  3.654181e-04  3.807857e-04
## ASV5837      2.957400e-04  3.094019e-04  3.236773e-04  3.385922e-04
## ASV7098      3.023087e-04  3.162273e-04  3.307673e-04  3.459547e-04
## ASV8451     -2.292370e-04 -2.384853e-04 -2.480421e-04 -2.579130e-04
## ASV8694     -2.292174e-04 -2.384641e-04 -2.480192e-04 -2.578882e-04
## ASV0905     -1.246042e-04 -1.303472e-04 -1.363393e-04 -1.425897e-04
## ASV2900      2.825392e-04  2.942833e-04  3.064498e-04  3.190490e-04
## ASV3963     -2.227559e-04 -2.317069e-04 -2.409533e-04 -2.505002e-04
## ASV0041     -2.535717e-04 -2.652582e-04 -2.774620e-04 -2.902038e-04
## ASV1865      2.612276e-04  2.738744e-04  2.871306e-04  3.010242e-04
## ASV1140      2.070061e-04  2.164846e-04  2.263728e-04  2.366859e-04
## ASV1179      3.057770e-04  3.198570e-04  3.345612e-04  3.499149e-04
## ASV0279      4.280213e-04  4.470098e-04  4.667842e-04  4.873725e-04
## ASV0043     -4.193883e-05 -4.449866e-05 -4.722852e-05 -5.014026e-05
## ASV2097     -2.387714e-04 -2.490360e-04 -2.597005e-04 -2.707776e-04
## ASV0309     -1.183511e-04 -1.233537e-04 -1.285432e-04 -1.339246e-04
## ASV0607      5.268438e-04  5.512485e-04  5.767498e-04  6.033938e-04
## ASV0025     -5.512709e-04 -5.766548e-04 -6.031626e-04 -6.308396e-04
## ASV2284     -8.357272e-05 -8.647226e-05 -8.942510e-05 -9.242804e-05
## ASV0556      9.557004e-05  1.004150e-04  1.055103e-04  1.108689e-04
## ASV5040      1.917354e-04  1.992825e-04  2.070647e-04  2.150849e-04
## ASV2924     -2.053404e-04 -2.135197e-04 -2.219627e-04 -2.306735e-04
## ASV1331      6.645774e-04  6.942620e-04  7.251878e-04  7.573994e-04
## ASV0506     -3.001568e-04 -3.128092e-04 -3.259254e-04 -3.395167e-04
## ASV1514      5.027962e-04  5.255499e-04  5.492775e-04  5.740155e-04
## ASV2144      4.150570e-04  4.333090e-04  4.522974e-04  4.720463e-04
## ASV2265      5.571163e-04  5.820948e-04  6.081235e-04  6.352404e-04
## ASV5156      1.167153e-04  1.211776e-04  1.257646e-04  1.304761e-04
## ASV5534      9.331636e-05  9.663039e-05  1.000125e-04  1.034598e-04
## ASV5747     -2.327453e-05 -2.530080e-05 -2.749253e-05 -2.986180e-05
## ASV6657      2.474785e-04  2.579738e-04  2.688606e-04  2.801493e-04
## ASV0658     -2.818163e-04 -2.937493e-04 -3.061257e-04 -3.189570e-04
## ASV0716      6.765309e-05  7.036893e-05  7.317110e-05  7.606039e-05
## ASV1657      1.180257e-04  1.225022e-04  1.271004e-04  1.318199e-04
## ASV1885     -1.051684e-05 -1.186958e-05 -1.335091e-05 -1.497090e-05
## ASV2333      6.125267e-04  6.395775e-04  6.677331e-04  6.970311e-04
## ASV3375      2.234613e-04  2.327692e-04  2.424110e-04  2.523945e-04
## ASV4317      2.407631e-04  2.517178e-04  2.631515e-04  2.750836e-04
## ASV9599     -2.334863e-05 -2.538101e-05 -2.757930e-05 -2.995561e-05
## ASV0175     -8.189482e-04 -8.548509e-04 -8.921895e-04 -9.310096e-04
## ASV1032      2.408363e-04  2.508691e-04  2.612607e-04  2.720192e-04
## ASV1235      2.972703e-06  2.432226e-06  1.813406e-06  1.109121e-06
## ASV1262      7.235390e-04  7.555469e-04  7.888625e-04  8.235298e-04
## ASV1320      1.832081e-04  1.923163e-04  2.018850e-04  2.119377e-04
## ASV13797     2.679655e-04  2.796315e-04  2.917623e-04  3.043730e-04
## ASV1491      1.404063e-04  1.474508e-04  1.548511e-04  1.626244e-04
## ASV15014    -2.337749e-05 -2.541191e-05 -2.761234e-05 -2.999090e-05
## ASV1510      2.253580e-04  2.362008e-04  2.475592e-04  2.594564e-04
## ASV1551     -8.803029e-05 -9.177640e-05 -9.566214e-05 -9.969099e-05
## ASV1919     -8.512447e-06 -7.886298e-06 -7.151221e-06 -6.296949e-06
## ASV2114      1.300233e-04  1.353163e-04  1.407911e-04  1.464516e-04
## ASV21486    -2.336392e-05 -2.539657e-05 -2.759500e-05 -2.997131e-05
## ASV2448      3.655663e-04  3.812156e-04  3.974602e-04  4.143164e-04
## ASV2589      1.740204e-04  1.812659e-04  1.887712e-04  1.965422e-04
## ASV2608      2.959435e-04  3.089505e-04  3.224851e-04  3.365652e-04
## ASV2786      2.410090e-04  2.518984e-04  2.632597e-04  2.751121e-04
## ASV2827      3.059929e-04  3.192736e-04  3.330749e-04  3.474126e-04
## ASV2872      2.473998e-04  2.576365e-04  2.682310e-04  2.791906e-04
## ASV3125      2.969475e-04  3.095543e-04  3.226339e-04  3.361993e-04
## ASV3247      3.215517e-04  3.351805e-04  3.493158e-04  3.639708e-04
## ASV3451     -2.347374e-05 -2.551582e-05 -2.772446e-05 -3.011179e-05
## ASV3465     -4.538125e-05 -4.847620e-05 -5.178941e-05 -5.533571e-05
## ASV3809      1.867506e-04  1.945115e-04  2.025487e-04  2.108681e-04
## ASV4006      3.982285e-04  4.149583e-04  4.322943e-04  4.502503e-04
## ASV4046      2.865397e-04  2.986982e-04  3.113118e-04  3.243929e-04
## ASV4938     -2.536786e-05 -2.749834e-05 -2.979933e-05 -3.228316e-05
## ASV5435     -2.350435e-05 -2.554847e-05 -2.775923e-05 -3.014877e-05
## ASV5605      1.122238e-04  1.162866e-04  1.204397e-04  1.246799e-04
## ASV5635     -2.350765e-05 -2.555175e-05 -2.776245e-05 -3.015187e-05
## ASV5743      3.626525e-04  3.783393e-04  3.946402e-04  4.115741e-04
## ASV6627     -2.352589e-05 -2.557143e-05 -2.778364e-05 -3.017469e-05
## ASV6785     -2.352167e-05 -2.556664e-05 -2.777823e-05 -3.016856e-05
## ASV7368      4.029291e-04  4.212488e-04  4.403666e-04  4.603146e-04
## ASV9118      1.061566e-04  1.100639e-04  1.140656e-04  1.181596e-04
## ASV9135      8.181717e-05  8.452614e-05  8.727011e-05  9.004428e-05
## ASV9435      1.860624e-04  1.933549e-04  2.008656e-04  2.085953e-04
## ASV9671     -2.355423e-05 -2.560164e-05 -2.781580e-05 -3.020886e-05
## ASV0387     -4.008407e-04 -4.178914e-04 -4.355811e-04 -4.539266e-04
## ASV0454     -3.995559e-04 -4.167674e-04 -4.346422e-04 -4.531995e-04
## ASV0751     -2.612084e-04 -2.722315e-04 -2.836604e-04 -2.955049e-04
## ASV1081      1.067848e-04  1.115417e-04  1.164941e-04  1.216484e-04
## ASV1332      2.192752e-04  2.289062e-04  2.389243e-04  2.493420e-04
## ASV2659      3.507445e-04  3.666108e-04  3.831520e-04  4.003929e-04
## ASV2979      3.600826e-04  3.752198e-04  3.909077e-04  4.071594e-04
## ASV4184      1.429688e-04  1.482411e-04  1.536400e-04  1.591627e-04
## ASV6198      1.265890e-04  1.318490e-04  1.372978e-04  1.429399e-04
## ASV7454      2.355186e-04  2.454974e-04  2.558469e-04  2.665768e-04
## ASV8198      9.169784e-05  9.478786e-05  9.792359e-05  1.011002e-04
## ASV0855      5.329219e-04  5.570160e-04  5.821431e-04  6.083425e-04
## ASV10092     2.230750e-04  2.325491e-04  2.423801e-04  2.525779e-04
## ASV1532      2.917248e-04  3.052899e-04  3.194688e-04  3.342877e-04
## ASV2553      7.004738e-04  7.317683e-04  7.643703e-04  7.983268e-04
## ASV2741      2.836378e-04  2.968808e-04  3.107226e-04  3.251880e-04
## ASV4095      1.552802e-04  1.629440e-04  1.709853e-04  1.794218e-04
## ASV5295      2.033668e-04  2.115318e-04  2.199612e-04  2.286583e-04
## ASV5787     -2.363019e-05 -2.568335e-05 -2.790363e-05 -3.030318e-05
## ASV9455      2.713283e-04  2.829274e-04  2.949694e-04  3.074674e-04
## ASV10879     2.846054e-04  2.971969e-04  3.103080e-04  3.239575e-04
## ASV3997      2.011267e-04  2.107512e-04  2.208293e-04  2.313812e-04
## ASV6760      5.248619e-05  5.377637e-05  5.503389e-05  5.625095e-05
## ASV6990      2.042249e-04  2.127947e-04  2.216787e-04  2.308852e-04
## ASV9560      1.253321e-04  1.302856e-04  1.353948e-04  1.406613e-04
## ASV0220      1.124628e-04  1.173737e-04  1.224777e-04  1.277802e-04
## ASV2518      2.753644e-04  2.877880e-04  3.007417e-04  3.142454e-04
## ASV3615      4.318507e-04  4.508803e-04  4.706837e-04  4.912871e-04
## ASV0075      9.182317e-05  9.536114e-05  9.899645e-05  1.027282e-04
## ASV8070      4.891296e-05  5.015214e-05  5.136563e-05  5.254660e-05
## ASV1658      2.033041e-04  2.119402e-04  2.209005e-04  2.301936e-04
## ASV0773      3.282058e-04  3.420900e-04  3.564875e-04  3.714111e-04
## ASV0799      1.054948e-05  1.100122e-05  1.146986e-05  1.195577e-05
## ASV1839     -6.326906e-05 -6.552197e-05 -6.781597e-05 -7.014763e-05
## ASV0265      3.219856e-04  3.372421e-04  3.532098e-04  3.699201e-04
## ASV3741      1.283691e-04  1.340493e-04  1.399616e-04  1.461141e-04
## ASV0847      4.465803e-04  4.664138e-04  4.870636e-04  5.085577e-04
## ASV1026      4.762467e-04  4.971925e-04  5.189818e-04  5.416420e-04
## ASV1222     -1.482640e-04 -1.540862e-04 -1.600866e-04 -1.662667e-04
## ASV0729      6.491319e-05  6.772644e-05  7.064902e-05  7.368406e-05
## ASV0143     -3.595960e-04 -3.747548e-04 -3.904680e-04 -4.067488e-04
## ASV1328      9.179215e-05  9.554686e-05  9.942989e-05  1.034436e-04
## ASV9078     -9.812415e-05 -1.036167e-04 -1.094298e-04 -1.155820e-04
## ASV0027     -5.245595e-04 -5.485647e-04 -5.736192e-04 -5.997641e-04
## ASV0546     -2.262817e-04 -2.358334e-04 -2.457370e-04 -2.560013e-04
## ASV1136      5.810917e-04  6.067675e-04  6.334939e-04  6.613073e-04
## ASV3081      2.783298e-04  2.908790e-04  3.039669e-04  3.176146e-04
## ASV0531      1.245379e-04  1.304326e-04  1.365991e-04  1.430486e-04
## ASV2525      1.581078e-04  1.648313e-04  1.718073e-04  1.790427e-04
## ASV1083     -5.857512e-05 -6.069173e-05 -6.285762e-05 -6.507183e-05
## ASV0424      1.040444e-04  1.087865e-04  1.137367e-04  1.189037e-04
## ASV0644      1.622399e-05  1.761845e-05  1.912433e-05  2.074944e-05
## ASV6007     -2.383838e-05 -2.591340e-05 -2.815787e-05 -3.058417e-05
## ASV0564      1.453691e-04  1.524172e-04  1.598048e-04  1.675475e-04
## ASV1938      1.524280e-04  1.586134e-04  1.650071e-04  1.716127e-04
## ASV6516     -3.547802e-04 -3.705296e-04 -3.869271e-04 -4.039949e-04
## ASV0503     -4.123776e-04 -4.296904e-04 -4.476297e-04 -4.662097e-04
## ASV6913     -4.097268e-04 -4.269327e-04 -4.447662e-04 -4.632427e-04
## ASV0164     -3.326829e-04 -3.482560e-04 -3.645436e-04 -3.815770e-04
## ASV1576      3.943784e-04  4.119147e-04  4.301797e-04  4.491994e-04
## ASV1725      1.940020e-04  2.033745e-04  2.131957e-04  2.234863e-04
## ASV4501      1.642759e-04  1.708519e-04  1.776393e-04  1.846409e-04
## ASV10678    -3.454619e-04 -3.606129e-04 -3.763708e-04 -3.927548e-04
## ASV0944      2.908390e-04  3.044403e-04  3.186630e-04  3.335339e-04
## ASV2292      4.483771e-04  4.680356e-04  4.884828e-04  5.097444e-04
## ASV1090      2.949674e-04  3.082273e-04  3.220502e-04  3.364572e-04
## ASV9117     -1.408261e-04 -1.463929e-04 -1.521342e-04 -1.580521e-04
## ASV0285     -1.772068e-04 -1.860125e-04 -1.952605e-04 -2.049726e-04
## ASV0463     -2.854383e-04 -2.976438e-04 -3.103110e-04 -3.234526e-04
## ASV3199      2.453357e-04  2.556113e-04  2.662595e-04  2.772894e-04
## ASV0150     -1.033761e-04 -1.084856e-04 -1.138498e-04 -1.194810e-04
## ASV6583     -1.453121e-04 -1.513117e-04 -1.575251e-04 -1.639576e-04
## ASV0392      2.363688e-04  2.470959e-04  2.582868e-04  2.699597e-04
## ASV14007    -2.843250e-04 -2.968283e-04 -3.098357e-04 -3.233636e-04
## ASV0177     -1.555384e-04 -1.620462e-04 -1.687890e-04 -1.757723e-04
## ASV6448     -1.261374e-04 -1.328268e-04 -1.398817e-04 -1.473218e-04
## ASV5399     -5.446451e-05 -5.791419e-05 -6.159135e-05 -6.551049e-05
## ASV0277     -5.914881e-05 -6.189185e-05 -6.475780e-05 -6.775167e-05
## ASV2599      9.271181e-05  9.562009e-05  9.854836e-05  1.014895e-04
## ASV13465    -7.344255e-05 -7.551860e-05 -7.758155e-05 -7.962317e-05
## ASV2412      1.479153e-04  1.546086e-04  1.615884e-04  1.688655e-04
## ASV0423      2.954526e-04  3.096904e-04  3.246181e-04  3.402691e-04
## ASV5187      1.767254e-04  1.837398e-04  1.909769e-04  1.984395e-04
## ASV0701     -6.795908e-04 -7.100973e-04 -7.418870e-04 -7.750061e-04
## ASV4248      1.647239e-04  1.726553e-04  1.809632e-04  1.896643e-04
## ASV0519      2.876335e-04  3.009991e-04  3.149652e-04  3.295567e-04
## ASV0764      5.102503e-05  5.378182e-05  5.669440e-05  5.977166e-05
## ASV5385     -3.581686e-04 -3.744006e-04 -3.913298e-04 -4.089827e-04
## ASV3021     -1.960424e-04 -2.035953e-04 -2.113659e-04 -2.193546e-04
## ASV4119     -1.086542e-04 -1.126939e-04 -1.168356e-04 -1.210778e-04
## ASV2534      5.768499e-05  6.014216e-05  6.269377e-05  6.534276e-05
## ASV1061      2.808804e-04  2.948960e-04  3.096288e-04  3.251161e-04
## ASV0670      3.818803e-04  3.991962e-04  4.172567e-04  4.360903e-04
## ASV1384      1.689575e-04  1.773288e-04  1.861187e-04  1.953476e-04
## ASV1981      3.566285e-04  3.729977e-04  3.900858e-04  4.079211e-04
## ASV9632     -1.125099e-04 -1.165129e-04 -1.206011e-04 -1.247715e-04
## ASV4564      8.812772e-05  9.222398e-05  9.650440e-05  1.009765e-04
## ASV5289     -7.913321e-05 -8.267561e-05 -8.636612e-05 -9.021001e-05
## ASV0516      7.232294e-04  7.558939e-04  7.899506e-04  8.254515e-04
## ASV1463     -2.580885e-04 -2.692004e-04 -2.807381e-04 -2.927131e-04
## ASV0969      1.194371e-04  1.244574e-04  1.296582e-04  1.350433e-04
## ASV1113     -3.368920e-04 -3.521050e-04 -3.679683e-04 -3.845067e-04
## ASV1234     -1.652310e-05 -1.818811e-05 -2.000495e-05 -2.198616e-05
## ASV3814      4.561291e-05  4.655020e-05  4.743685e-05  4.826420e-05
## ASV1000      3.420029e-04  3.569434e-04  3.724766e-04  3.886211e-04
## ASV0079     -3.326592e-05 -3.534825e-05 -3.757075e-05 -3.994310e-05
## ASV0145      1.144128e-04  1.190589e-04  1.238612e-04  1.288226e-04
## ASV0457     -4.297652e-04 -4.483455e-04 -4.676479e-04 -4.876935e-04
## ASV1485      1.424821e-04  1.491652e-04  1.561569e-04  1.634710e-04
## ASV0535     -9.458121e-05 -9.865062e-05 -1.028808e-04 -1.072773e-04
## ASV0259     -2.825791e-04 -2.950555e-04 -3.080358e-04 -3.215361e-04
## ASV0570      2.345542e-05  2.503417e-05  2.672407e-05  2.853277e-05
## ASV0906      3.666895e-04  3.827276e-04  3.994046e-04  4.167409e-04
## ASV1748     -2.222460e-04 -2.332352e-04 -2.447715e-04 -2.568813e-04
## ASV5520     -1.339450e-04 -1.410706e-04 -1.485895e-04 -1.565234e-04
## ASV2288     -4.180091e-04 -4.357828e-04 -4.542206e-04 -4.733397e-04
## ASV1887     -8.418435e-05 -8.882873e-05 -9.373816e-05 -9.892740e-05
## ASV0374     -1.321799e-04 -1.376920e-04 -1.434005e-04 -1.493096e-04
## ASV0823      4.127542e-04  4.305274e-04  4.489871e-04  4.681534e-04
## ASV0717      2.101832e-04  2.197981e-04  2.298345e-04  2.403091e-04
## ASV0431      1.429580e-04  1.490598e-04  1.553909e-04  1.619572e-04
## ASV1030      6.107868e-04  6.392766e-04  6.690599e-04  7.001917e-04
## ASV1082     -8.866059e-05 -9.266516e-05 -9.684010e-05 -1.011916e-04
## ASV2684      5.970753e-05  6.316865e-05  6.683752e-05  7.072612e-05
## ASV0051      5.411980e-04  5.661016e-04  5.921114e-04  6.192727e-04
## ASV0513      2.333499e-05  2.453172e-05  2.579237e-05  2.712049e-05
## ASV0581      6.844217e-04  7.154424e-04  7.477956e-04  7.815318e-04
## ASV7282      1.236421e-04  1.300584e-04  1.368235e-04  1.439572e-04
## ASV3009     -3.747646e-04 -3.916469e-04 -4.092451e-04 -4.275858e-04
## ASV2106     -1.873394e-04 -1.951393e-04 -2.032178e-04 -2.115811e-04
## ASV1012      1.224728e-04  1.284923e-04  1.348097e-04  1.414392e-04
## ASV0921     -7.192927e-06 -7.334583e-06 -7.465997e-06 -7.585362e-06
## ASV0010     -5.372451e-04 -5.620370e-04 -5.879317e-04 -6.149743e-04
## ASV1178      1.213248e-05  1.290810e-05  1.373384e-05  1.461267e-05
## ASV2848     -2.853668e-04 -2.977856e-04 -3.106979e-04 -3.241197e-04
## ASV0586      7.769753e-04  8.123395e-04  8.492367e-04  8.877265e-04
## ASV4225      2.510813e-05  2.669080e-05  2.837141e-05  3.015512e-05
## ASV2156     -3.236729e-04 -3.383629e-04 -3.536869e-04 -3.696693e-04
## ASV9778     -2.030002e-04 -2.119733e-04 -2.213116e-04 -2.310272e-04
## ASV0493     -4.487606e-04 -4.684457e-04 -4.889226e-04 -5.102173e-04
## ASV3770      8.111175e-05  8.439847e-05  8.779820e-05  9.131359e-05
## ASV0470      5.505886e-04  5.754060e-04  6.012797e-04  6.282490e-04
## ASV0262     -2.339920e-04 -2.455407e-04 -2.576658e-04 -2.703955e-04
## ASV0998      3.385876e-04  3.540582e-04  3.702058e-04  3.870574e-04
## ASV7708     -9.141477e-05 -9.535656e-05 -9.945011e-05 -1.036997e-04
## ASV0453     -1.141553e-05 -1.189279e-05 -1.238988e-05 -1.290786e-05
## ASV0044      6.944381e-04  7.258926e-04  7.586994e-04  7.929103e-04
## ASV5490      1.076294e-04  1.122120e-04  1.169642e-04  1.218897e-04
## ASV2638      3.056667e-05  3.213523e-05  3.378278e-05  3.551274e-05
## ASV0829     -5.967557e-05 -6.184781e-05 -6.407174e-05 -6.634643e-05
## ASV0601      1.294379e-04  1.356607e-04  1.421836e-04  1.490207e-04
## ASV0234      3.007088e-04  3.141530e-04  3.281588e-04  3.427461e-04
## ASV0133      3.988880e-04  4.170369e-04  4.359737e-04  4.557290e-04
## ASV0323      4.253112e-04  4.451754e-04  4.659489e-04  4.876717e-04
## ASV0854     -3.084166e-05 -3.194908e-05 -3.307773e-05 -3.422604e-05
## ASV0110      5.367064e-04  5.614385e-04  5.872710e-04  6.142490e-04
## ASV0816      2.860478e-05  2.981271e-05  3.106630e-05  3.236698e-05
## ASV1031     -8.287405e-05 -8.641820e-05 -9.010082e-05 -9.392664e-05
## ASV0144     -2.173951e-04 -2.271015e-04 -2.372126e-04 -2.477425e-04
## ASV0020     -1.031328e-04 -1.085737e-04 -1.143197e-04 -1.203888e-04
## ASV0962     -1.781467e-04 -1.861472e-04 -1.944845e-04 -2.031706e-04
## ASV0794      3.561408e-04  3.731749e-04  3.910163e-04  4.097017e-04
## ASV7117     -1.821595e-04 -1.904748e-04 -1.991549e-04 -2.082146e-04
## ASV1008     -1.312111e-04 -1.374837e-04 -1.440554e-04 -1.509405e-04
## ASV0096      5.782066e-04  6.048752e-04  6.327326e-04  6.618279e-04
## ASV0128     -3.488666e-04 -3.655777e-04 -3.830900e-04 -4.014418e-04
## ASV5232      2.623640e-04  2.745067e-04  2.871912e-04  3.004395e-04
## ASV0031      1.480747e-05  1.507746e-05  1.532256e-05  1.553855e-05
## ASV1744     -4.032354e-05 -4.230480e-05 -4.438925e-05 -4.658294e-05
## ASV0289      3.214222e-04  3.361404e-04  3.515081e-04  3.675517e-04
## ASV7413     -7.619130e-05 -8.057309e-05 -8.521841e-05 -9.014289e-05
## ASV0822     -3.834018e-04 -4.000827e-04 -4.174216e-04 -4.354390e-04
## ASV8111     -3.205592e-04 -3.337305e-04 -3.473582e-04 -3.614515e-04
## ASV0687      2.426080e-04  2.539847e-04  2.658816e-04  2.783209e-04
## ASV0112      7.097683e-05  7.306965e-05  7.514933e-05  7.720598e-05
## ASV0987      1.956379e-04  2.048410e-04  2.144699e-04  2.245436e-04
## ASV5332     -1.039563e-04 -1.080687e-04 -1.123140e-04 -1.166945e-04
## ASV1129     -2.544849e-04 -2.661817e-04 -2.783990e-04 -2.911583e-04
## ASV1274     -8.350465e-05 -8.734561e-05 -9.135649e-05 -9.554415e-05
## ASV0119      4.709103e-04  4.925904e-04  5.152332e-04  5.388781e-04
## ASV0890      1.200997e-04  1.258341e-04  1.318406e-04  1.381317e-04
## ASV0848      6.738483e-04  7.045135e-04  7.365076e-04  7.698822e-04
## ASV5944     -3.469852e-04 -3.616818e-04 -3.769235e-04 -3.927241e-04
## ASV19741    -3.522785e-04 -3.681849e-04 -3.847715e-04 -4.020643e-04
## ASV0504     -4.014043e-04 -4.189863e-04 -4.372737e-04 -4.562892e-04
## ASV2146     -2.638933e-04 -2.755910e-04 -2.877764e-04 -3.004679e-04
## ASV0089     -2.232898e-04 -2.338624e-04 -2.449283e-04 -2.565095e-04
## ASV2301     -2.351690e-04 -2.460181e-04 -2.573508e-04 -2.691870e-04
## ASV2982      7.166119e-05  7.520303e-05  7.891458e-05  8.280279e-05
## ASV0891     -2.966499e-04 -3.101119e-04 -3.241548e-04 -3.388010e-04
## ASV0093      4.815794e-04  5.034127e-04  5.261864e-04  5.499367e-04
## ASV0042      2.266363e-04  2.366128e-04  2.469925e-04  2.577886e-04
## ASV0980      3.176167e-04  3.316134e-04  3.461767e-04  3.613252e-04
## ASV0069     -8.229109e-05 -8.638787e-05 -9.069452e-05 -9.522212e-05
## ASV1364     -5.737190e-05 -6.004052e-05 -6.283073e-05 -6.574786e-05
## ASV0524     -9.466125e-05 -9.931184e-05 -1.041951e-04 -1.093230e-04
## ASV0435      6.379909e-04  6.671757e-04  6.976403e-04  7.294357e-04
## ASV0517     -2.585718e-04 -2.702816e-04 -2.824935e-04 -2.952265e-04
## ASV3167     -1.125464e-04 -1.178578e-04 -1.234138e-04 -1.292248e-04
## ASV4280     -4.810811e-05 -5.057763e-05 -5.318119e-05 -5.592661e-05
## ASV1158      1.577136e-04  1.653840e-04  1.734241e-04  1.818504e-04
## ASV2214      1.208805e-04  1.264413e-04  1.322549e-04  1.383331e-04
## ASV0544     -1.434827e-04 -1.500863e-04 -1.569825e-04 -1.641832e-04
## ASV5326     -2.573089e-05 -2.684508e-05 -2.800309e-05 -2.920632e-05
## ASV3765     -3.691949e-04 -3.854078e-04 -4.022705e-04 -4.198038e-04
## ASV4646     -1.228879e-05 -1.357978e-05 -1.498604e-05 -1.651648e-05
## ASV0090      3.564113e-05  3.688286e-05  3.814499e-05  3.942548e-05
## ASV3680      3.464188e-04  3.611947e-04  3.765268e-04  3.924298e-04
## ASV0111      5.678135e-05  5.902641e-05  6.133902e-05  6.371925e-05
## ASV0768      2.185074e-04  2.285521e-04  2.390426e-04  2.499972e-04
## ASV4862     -1.230824e-05 -1.275886e-05 -1.321958e-05 -1.369002e-05
## ASV1742     -2.847529e-04 -2.970017e-04 -3.097246e-04 -3.229358e-04
## ASV3701     -5.091764e-05 -5.332511e-05 -5.584639e-05 -5.848686e-05
## ASV2386     -1.728421e-04 -1.805729e-04 -1.886257e-04 -1.970120e-04
## ASV0375     -4.019704e-04 -4.194962e-04 -4.377178e-04 -4.566570e-04
## ASV2796      1.070557e-04  1.116646e-04  1.164521e-04  1.214235e-04
## ASV1369      2.779820e-04  2.901597e-04  3.028285e-04  3.160047e-04
## ASV10272    -2.525297e-04 -2.637508e-04 -2.754338e-04 -2.875945e-04
## ASV10354    -2.525056e-04 -2.637245e-04 -2.754052e-04 -2.875633e-04
## ASV1067     -2.211866e-05 -2.323625e-05 -2.441236e-05 -2.565018e-05
## ASV1900      5.321189e-04  5.564894e-04  5.819303e-04  6.084843e-04
## ASV4079     -9.180275e-05 -9.613799e-05 -1.006738e-04 -1.054190e-04
## ASV4149      3.529728e-04  3.680701e-04  3.837388e-04  3.999944e-04
## ASV5140     -2.524813e-04 -2.636979e-04 -2.753761e-04 -2.875316e-04
## ASV10782    -1.064707e-05 -1.091722e-05 -1.118007e-05 -1.143374e-05
## ASV4273     -5.698658e-05 -5.927402e-05 -6.163298e-05 -6.406381e-05
## ASV8121      2.451077e-04  2.563429e-04  2.680743e-04  2.803222e-04
## ASV8438     -2.524604e-04 -2.636752e-04 -2.753515e-04 -2.875048e-04
## ASV9390     -2.524364e-04 -2.636490e-04 -2.753229e-04 -2.874737e-04
## ASV1340      3.523871e-04  3.686242e-04  3.855826e-04  4.032916e-04
## ASV2650     -3.738406e-04 -3.901930e-04 -4.071958e-04 -4.248692e-04
## ASV4674      1.927629e-04  2.014928e-04  2.105972e-04  2.200901e-04
## ASV10492    -1.693898e-05 -1.778586e-05 -1.867650e-05 -1.961322e-05
## ASV11430    -2.524009e-04 -2.636104e-04 -2.752809e-04 -2.874280e-04
## ASV12135    -2.523769e-04 -2.635842e-04 -2.752523e-04 -2.873968e-04
## ASV14970    -2.523528e-04 -2.635580e-04 -2.752237e-04 -2.873657e-04
## ASV1954      2.890681e-04  3.021562e-04  3.158047e-04  3.300345e-04
## ASV2613      4.511111e-04  4.714058e-04  4.925600e-04  5.146053e-04
## ASV2757      1.766357e-04  1.841824e-04  1.920142e-04  2.001387e-04
## ASV2909     -2.649563e-04 -2.770248e-04 -2.896170e-04 -3.027531e-04
## ASV2954     -5.000410e-05 -5.204750e-05 -5.415829e-05 -5.633720e-05
## ASV2969      2.510113e-04  2.626978e-04  2.749147e-04  2.876845e-04
## ASV3410      5.510971e-05  5.794393e-05  6.093076e-05  6.407881e-05
## ASV3575      1.329613e-04  1.390334e-04  1.453726e-04  1.519898e-04
## ASV4275      2.849853e-04  2.972532e-04  3.099915e-04  3.232134e-04
## ASV4652      5.198448e-05  5.465766e-05  5.747332e-05  6.043921e-05
## ASV4761      2.847977e-04  2.970740e-04  3.098212e-04  3.230525e-04
## ASV6003      2.250331e-04  2.357799e-04  2.470394e-04  2.588357e-04
## ASV6110     -2.524055e-04 -2.636156e-04 -2.752867e-04 -2.874346e-04
## ASV7427      1.657689e-04  1.732834e-04  1.811214e-04  1.892954e-04
## ASV8092     -2.523901e-04 -2.635989e-04 -2.752685e-04 -2.874148e-04
## ASV8169     -2.523661e-04 -2.635727e-04 -2.752399e-04 -2.873836e-04
## ASV9693      1.109935e-04  1.160605e-04  1.213484e-04  1.268659e-04
## ASV10913     1.234852e-04  1.293721e-04  1.355380e-04  1.419959e-04
## ASV1979     -4.084768e-05 -4.258866e-05 -4.439504e-05 -4.626855e-05
## ASV3772      3.129354e-04  3.268134e-04  3.412624e-04  3.563023e-04
## ASV0113      5.787011e-05  6.016406e-05  6.252618e-05  6.495626e-05
## ASV1800     -2.738462e-05 -2.870715e-05 -3.009196e-05 -3.154169e-05
## ASV2335     -3.131403e-04 -3.260208e-04 -3.393485e-04 -3.531325e-04
## ASV0692      1.097985e-04  1.149073e-04  1.202469e-04  1.258269e-04
## ASV1120      1.376592e-04  1.438714e-04  1.503479e-04  1.570987e-04
## ASV1434     -7.303360e-04 -7.633368e-04 -7.977487e-04 -8.336250e-04
## ASV0076     -8.636962e-05 -9.064715e-05 -9.514198e-05 -9.986544e-05
## ASV0361      5.551282e-04  5.806641e-04  6.073316e-04  6.351769e-04
## ASV2231     -1.899951e-04 -1.995004e-04 -2.094951e-04 -2.200049e-04
## ASV2018     -1.733641e-05 -1.860842e-05 -1.998061e-05 -2.146105e-05
## ASV1529      4.615008e-04  4.829101e-04  5.052852e-04  5.286669e-04
## ASV0841     -2.227184e-05 -2.308953e-05 -2.392518e-05 -2.477800e-05
## ASV2556     -2.752863e-04 -2.875752e-04 -3.003753e-04 -3.137043e-04
## ASV2777      3.447560e-04  3.594417e-04  3.746780e-04  3.904795e-04
## ASV0355      2.880167e-04  3.013408e-04  3.152635e-04  3.298104e-04
## ASV5169     -3.914774e-04 -4.090199e-04 -4.272981e-04 -4.463384e-04
## ASV3091      1.942156e-04  2.034266e-04  2.130708e-04  2.231682e-04
## ASV2435      2.757604e-04  2.879884e-04  3.007164e-04  3.139611e-04
## ASV6822     -1.781293e-04 -1.860445e-04 -1.942854e-04 -2.028632e-04
## ASV12605    -4.275867e-04 -4.467928e-04 -4.668089e-04 -4.876646e-04
## ASV0286     -2.861620e-04 -2.990606e-04 -3.125111e-04 -3.265348e-04
## ASV0074     -2.098570e-05 -2.272303e-05 -2.460583e-05 -2.664591e-05
## ASV2485     -1.029773e-05 -1.046408e-05 -1.061330e-05 -1.074295e-05
## ASV1233     -5.482252e-04 -5.732194e-04 -5.993039e-04 -6.265221e-04
## ASV0356     -2.603853e-04 -2.719322e-04 -2.839556e-04 -2.964720e-04
## ASV2918     -3.117891e-04 -3.248781e-04 -3.384420e-04 -3.524923e-04
## ASV1427     -1.238999e-06 -1.490441e-06 -1.770616e-06 -2.082249e-06
## ASV1409      3.234161e-04  3.386575e-04  3.546088e-04  3.713023e-04
## ASV0770      9.572683e-05  9.944756e-05  1.032696e-04  1.071911e-04
## ASV1403     -3.839526e-04 -4.012292e-04 -4.192377e-04 -4.380051e-04
## ASV0314     -2.088096e-04 -2.182948e-04 -2.281887e-04 -2.385067e-04
## ASV0187      2.488085e-06  2.208358e-06  1.884481e-06  1.512367e-06
## ASV0313     -2.772640e-04 -2.894307e-04 -3.020854e-04 -3.152437e-04
## ASV1087      4.880899e-04  5.104349e-04  5.337619e-04  5.581105e-04
## ASV1970      2.483639e-05  2.575647e-05  2.669758e-05  2.765890e-05
## ASV0754      3.927620e-04  4.107434e-04  4.295154e-04  4.491101e-04
## ASV3775     -2.686490e-04 -2.811431e-04 -2.942035e-04 -3.078546e-04
## ASV0132      1.083709e-04  1.130476e-04  1.179031e-04  1.229419e-04
## ASV2329     -8.029237e-05 -8.473666e-05 -8.943817e-05 -9.441177e-05
## ASV0561      3.326808e-04  3.473227e-04  3.625548e-04  3.783960e-04
## ASV0130     -4.101906e-04 -4.288634e-04 -4.483450e-04 -4.686668e-04
## ASV0226      4.650530e-04  4.861585e-04  5.081734e-04  5.311325e-04
## ASV12648    -3.288522e-04 -3.435364e-04 -3.588376e-04 -3.747787e-04
## ASV0204      4.635429e-04  4.845697e-04  5.065016e-04  5.293732e-04
## ASV0767      7.439796e-05  7.715891e-05  7.998239e-05  8.286565e-05
## ASV0335     -2.544382e-04 -2.660945e-04 -2.782621e-04 -2.909614e-04
## ASV5901     -7.395629e-05 -7.692843e-05 -7.999751e-05 -8.316493e-05
## ASV0596     -9.507448e-05 -9.880239e-05 -1.026387e-04 -1.065829e-04
## ASV9271      9.822449e-05  1.033733e-04  1.088006e-04  1.145212e-04
## ASV0904      4.095079e-04  4.282808e-04  4.478804e-04  4.683400e-04
## ASV15270    -1.084696e-04 -1.137739e-04 -1.193330e-04 -1.251583e-04
## ASV0990     -1.194971e-04 -1.252103e-04 -1.311962e-04 -1.374676e-04
## ASV0155     -2.453602e-04 -2.563684e-04 -2.678401e-04 -2.797920e-04
## ASV0086     -5.636050e-07 -4.633141e-07 -3.475560e-07 -2.147845e-07
## ASV2581     -1.317958e-05 -1.337212e-05 -1.353472e-05 -1.366263e-05
## ASV1579     -2.930503e-04 -3.069093e-04 -3.214159e-04 -3.365995e-04
## ASV7730     -1.463029e-05 -1.588998e-05 -1.725060e-05 -1.871929e-05
## ASV0897      1.192812e-04  1.247623e-04  1.304857e-04  1.364612e-04
## ASV1975      5.585578e-04  5.838077e-04  6.101389e-04  6.375924e-04
## ASV0759     -1.279135e-05 -1.324121e-05 -1.369931e-05 -1.416505e-05
## ASV3082     -3.397360e-04 -3.552409e-04 -3.714227e-04 -3.883082e-04
## ASV3195     -5.950474e-04 -6.226641e-04 -6.515292e-04 -6.816961e-04
## ASV0427      3.125494e-04  3.271071e-04  3.423267e-04  3.582366e-04
## ASV2674      6.341197e-05  6.608756e-05  6.885779e-05  7.172415e-05
## ASV1500      9.633076e-05  1.006819e-04  1.052197e-04  1.099512e-04
## ASV0102     -3.582224e-04 -3.750299e-04 -3.926128e-04 -4.110056e-04
## ASV1217     -8.833342e-05 -9.205873e-05 -9.591803e-05 -9.991393e-05
## ASV4998     -3.731017e-05 -3.899709e-05 -4.075573e-05 -4.258869e-05
## ASV2890      5.052812e-04  5.277638e-04  5.511770e-04  5.755535e-04
## ASV0672     -2.209273e-04 -2.310590e-04 -2.416379e-04 -2.526823e-04
## ASV6960     -2.024731e-04 -2.122742e-04 -2.225454e-04 -2.333079e-04
## ASV0821      3.270909e-04  3.414338e-04  3.563531e-04  3.718677e-04
## ASV1995     -3.153251e-04 -3.297644e-04 -3.448377e-04 -3.605704e-04
## ASV0211     -1.800056e-04 -1.887748e-04 -1.979736e-04 -2.076227e-04
## ASV0364      1.844119e-04  1.929174e-04  2.018029e-04  2.110843e-04
## ASV3616      3.892828e-04  4.059061e-04  4.231569e-04  4.410519e-04
## ASV1996      4.447866e-04  4.648704e-04  4.858147e-04  5.076526e-04
## ASV1881     -7.274246e-05 -7.613170e-05 -7.967492e-05 -8.337869e-05
## ASV1089      4.335930e-04  4.531563e-04  4.735521e-04  4.948114e-04
## ASV1450     -8.838329e-05 -9.223286e-05 -9.623405e-05 -1.003914e-04
## ASV4643     -2.474638e-04 -2.585903e-04 -2.701866e-04 -2.822698e-04
## ASV3458      1.228268e-04  1.285123e-04  1.344453e-04  1.406347e-04
## ASV2543     -1.100270e-04 -1.152904e-04 -1.208053e-04 -1.265835e-04
## ASV3306     -1.240830e-04 -1.298204e-04 -1.358072e-04 -1.420522e-04
## ASV0218     -2.424077e-04 -2.535319e-04 -2.651488e-04 -2.772786e-04
## ASV3727      1.643372e-04  1.722942e-04  1.806394e-04  1.893916e-04
## ASV4394     -1.765659e-04 -1.849410e-04 -1.937087e-04 -2.028867e-04
## ASV2636      1.747637e-05  1.910753e-05  2.088492e-05  2.282094e-05
## ASV5116      4.331967e-05  4.520172e-05  4.715751e-05  4.918922e-05
## ASV1394     -4.312693e-04 -4.510047e-04 -4.716068e-04 -4.931106e-04
## ASV0656     -4.211813e-04 -4.400466e-04 -4.597031e-04 -4.801796e-04
## ASV0475      6.437073e-04  6.733302e-04  7.042677e-04  7.365738e-04
## ASV1042      1.604599e-04  1.677825e-04  1.754236e-04  1.833953e-04
## ASV1199     -3.328238e-04 -3.482842e-04 -3.644448e-04 -3.813358e-04
## ASV12962    -2.165454e-05 -2.252630e-05 -2.342594e-05 -2.435370e-05
## ASV0853      3.000358e-04  3.135851e-04  3.277083e-04  3.424261e-04
## ASV5069     -7.316144e-05 -7.752529e-05 -8.216373e-05 -8.709401e-05
## ASV7825     -1.876796e-04 -1.962705e-04 -2.052376e-04 -2.145960e-04
## ASV0339      2.102360e-04  2.198614e-04  2.299103e-04  2.404001e-04
## ASV2965      1.832569e-04  1.916764e-04  2.004675e-04  2.096453e-04
## ASV2347     -2.413623e-04 -2.519958e-04 -2.630608e-04 -2.745717e-04
## ASV0541      1.084639e-04  1.138390e-04  1.194860e-04  1.254189e-04
## ASV0369      2.841952e-04  2.970030e-04  3.103550e-04  3.242714e-04
## ASV0171      1.443173e-04  1.509384e-04  1.578533e-04  1.650742e-04
## ASV2235      3.417480e-04  3.563649e-04  3.715368e-04  3.872794e-04
## ASV5809     -3.234772e-04 -3.379435e-04 -3.530141e-04 -3.687104e-04
## ASV1267      4.080877e-04  4.264764e-04  4.456445e-04  4.656206e-04
## ASV0207     -4.389761e-04 -4.586571e-04 -4.791638e-04 -5.005260e-04
## ASV3126     -5.222630e-04 -5.464056e-04 -5.716291e-04 -5.979785e-04
## ASV0183     -5.736763e-04 -5.997196e-04 -6.268873e-04 -6.552229e-04
## ASV1792      1.953003e-04  2.038758e-04  2.127948e-04  2.220679e-04
## ASV2001     -5.082219e-04 -5.318149e-04 -5.564751e-04 -5.822485e-04
## ASV5732     -4.975883e-04 -5.201709e-04 -5.437266e-04 -5.682925e-04
## ASV2857     -3.161891e-04 -3.307695e-04 -3.460008e-04 -3.619101e-04
## ASV1052     -2.289727e-04 -2.391913e-04 -2.498381e-04 -2.609290e-04
## ASV3226     -1.464332e-04 -1.531168e-04 -1.600920e-04 -1.673705e-04
## ASV3766     -5.429090e-05 -5.680948e-05 -5.944201e-05 -6.219339e-05
## ASV0982     -1.598513e-04 -1.675214e-04 -1.755599e-04 -1.839844e-04
## ASV0489     -5.695156e-06 -6.486937e-06 -7.360053e-06 -8.321675e-06
## ASV3990     -5.427890e-04 -5.678099e-04 -5.939455e-04 -6.212419e-04
## ASV0433     -3.198502e-04 -3.340252e-04 -3.487786e-04 -3.641296e-04
## ASV0684     -1.401887e-04 -1.469399e-04 -1.540198e-04 -1.614446e-04
## ASV0063     -3.801278e-04 -3.973874e-04 -4.153902e-04 -4.341643e-04
## ASV1399      6.226187e-05  6.444963e-05  6.667313e-05  6.892837e-05
## ASV3093     -6.477116e-04 -6.777976e-04 -7.092461e-04 -7.421156e-04
## ASV1771      8.008772e-05  8.397828e-05  8.805952e-05  9.234078e-05
## ASV7910     -3.215510e-04 -3.352440e-04 -3.494505e-04 -3.641840e-04
## ASV3718     -4.322401e-04 -4.519883e-04 -4.726002e-04 -4.941101e-04
## ASV0039     -3.422787e-04 -3.584116e-04 -3.752919e-04 -3.929528e-04
## ASV6469     -7.052186e-04 -7.371440e-04 -7.704374e-04 -8.051504e-04
## ASV8186     -4.783525e-04 -5.001924e-04 -5.229862e-04 -5.467719e-04
## ASV1091     -4.937449e-05 -5.178645e-05 -5.431786e-05 -5.697469e-05
## ASV16930    -5.852471e-04 -6.120673e-04 -6.400676e-04 -6.692957e-04
## ASV7234     -4.380936e-04 -4.581312e-04 -4.790472e-04 -5.008766e-04
## ASV1560     -5.303329e-05 -5.554945e-05 -5.818379e-05 -6.094172e-05
## ASV2968      8.964498e-05  9.401568e-05  9.860290e-05  1.034176e-04
## ASV3824     -4.496174e-04 -4.699704e-04 -4.911972e-04 -5.133313e-04
## ASV0442     -2.814578e-04 -2.944720e-04 -3.080693e-04 -3.222738e-04
## ASV0677     -2.110477e-04 -2.200223e-04 -2.293315e-04 -2.389835e-04
## ASV4796     -2.983822e-04 -3.116942e-04 -3.255627e-04 -3.400080e-04
## ASV2206     -4.785939e-04 -5.005833e-04 -5.235457e-04 -5.475210e-04
## ASV2884      9.538158e-05  9.976977e-05  1.043522e-04  1.091368e-04
## ASV0482     -1.739704e-04 -1.820307e-04 -1.904541e-04 -1.992561e-04
## ASV1273      3.981922e-04  4.166251e-04  4.358809e-04  4.559932e-04
## ASV1910      5.124847e-05  5.322213e-05  5.524979e-05  5.733085e-05
## ASV0105      2.986574e-04  3.117296e-04  3.253223e-04  3.394519e-04
## ASV0149      3.189315e-04  3.334977e-04  3.487000e-04  3.645636e-04
## ASV5007     -4.974929e-04 -5.203869e-04 -5.442967e-04 -5.692641e-04
## ASV0757      4.299277e-04  4.497981e-04  4.705590e-04  4.922478e-04
## ASV11952    -3.543998e-04 -3.702245e-04 -3.867073e-04 -4.038714e-04
## ASV4102      2.836334e-04  2.966970e-04  3.103404e-04  3.245874e-04
## ASV1034      3.565959e-04  3.726847e-04  3.894603e-04  4.069487e-04
## ASV0753      2.651958e-04  2.772687e-04  2.898664e-04  3.030093e-04
## ASV2323      1.614547e-04  1.689816e-04  1.768512e-04  1.850782e-04
## ASV0881     -1.246953e-04 -1.301725e-04 -1.358682e-04 -1.417891e-04
## ASV3730     -3.327926e-04 -3.479024e-04 -3.636642e-04 -3.801030e-04
## ASV2685     -1.263464e-04 -1.317449e-04 -1.373449e-04 -1.431511e-04
## ASV3826     -6.312413e-05 -6.602554e-05 -6.905656e-05 -7.222275e-05
## ASV0689      3.034958e-05  3.205434e-05  3.386240e-05  3.578041e-05
## ASV4315     -4.369702e-04 -4.571089e-04 -4.781449e-04 -5.001156e-04
## ASV1239      2.077933e-04  2.165064e-04  2.255349e-04  2.348862e-04
## ASV3147     -7.316300e-05 -7.667680e-05 -8.035977e-05 -8.421999e-05
## ASV3454     -3.252062e-04 -3.399606e-04 -3.553514e-04 -3.714034e-04
## ASV4411     -1.952307e-04 -2.044908e-04 -2.141883e-04 -2.243436e-04
## ASV3007      3.876795e-04  4.049149e-04  4.228607e-04  4.415413e-04
## ASV6151     -3.138396e-04 -3.276406e-04 -3.420001e-04 -3.569369e-04
## ASV0834      3.327965e-04  3.482633e-04  3.644294e-04  3.813247e-04
## ASV1231      4.761466e-04  4.978317e-04  5.204583e-04  5.440630e-04
## ASV0643      4.013175e-04  4.195613e-04  4.385940e-04  4.584459e-04
## ASV0924      1.163443e-05  1.216297e-05  1.271255e-05  1.328359e-05
## ASV3238     -1.974043e-04 -2.061460e-04 -2.152447e-04 -2.247124e-04
## ASV1276     -2.332785e-04 -2.438698e-04 -2.549178e-04 -2.664398e-04
## ASV5503     -6.302436e-04 -6.586488e-04 -6.882598e-04 -7.191207e-04
## ASV0404      2.548765e-04  2.666797e-04  2.790130e-04  2.918984e-04
## ASV3430      4.170990e-05  4.446858e-05  4.742429e-05  5.059148e-05
## ASV5401     -2.702829e-04 -2.827245e-04 -2.957186e-04 -3.092878e-04
## ASV3426     -5.747508e-04 -6.008121e-04 -6.279949e-04 -6.563421e-04
## ASV0777      3.421732e-04  3.577218e-04  3.739426e-04  3.908614e-04
## ASV11093    -2.300942e-04 -2.405723e-04 -2.515060e-04 -2.629133e-04
## ASV2170     -1.993009e-04 -2.081162e-04 -2.172904e-04 -2.268353e-04
## ASV3861      1.798393e-04  1.875564e-04  1.955661e-04  2.038759e-04
## ASV1723     -3.350700e-04 -3.504358e-04 -3.664784e-04 -3.832248e-04
## ASV2460     -1.901820e-04 -1.990124e-04 -2.082416e-04 -2.178865e-04
## ASV1218     -2.738104e-04 -2.860038e-04 -2.987028e-04 -3.119252e-04
## ASV0436      1.603521e-05  1.635116e-05  1.664378e-05  1.690893e-05
## ASV0919      2.336926e-04  2.441885e-04  2.551278e-04  2.665266e-04
## ASV0577      9.984433e-05  1.042938e-04  1.089273e-04  1.137512e-04
## ASV2517      2.655017e-04  2.773346e-04  2.896576e-04  3.024875e-04
## ASV2628     -3.246544e-04 -3.396230e-04 -3.552566e-04 -3.715822e-04
## ASV1743     -2.967459e-04 -3.105914e-04 -3.250681e-04 -3.402034e-04
## ASV1678     -2.563646e-04 -2.684408e-04 -2.810784e-04 -2.943028e-04
## ASV0315      3.326363e-04  3.479282e-04  3.638976e-04  3.805725e-04
## ASV0253      1.546192e-04  1.616002e-04  1.688779e-04  1.764634e-04
## ASV1363      4.178400e-04  4.362475e-04  4.553975e-04  4.753137e-04
## ASV0995     -2.317588e-04 -2.424199e-04 -2.535542e-04 -2.651812e-04
## ASV4185     -1.001810e-04 -1.044291e-04 -1.088344e-04 -1.134009e-04
## ASV0782      2.121100e-04  2.221391e-04  2.326390e-04  2.436313e-04
## ASV3240     -2.516714e-04 -2.633638e-04 -2.755860e-04 -2.883610e-04
## ASV1392     -4.563379e-04 -4.774598e-04 -4.995312e-04 -5.225923e-04
## ASV8488     -1.038367e-04 -1.086628e-04 -1.137087e-04 -1.189841e-04
## ASV2814     -1.691333e-04 -1.769389e-04 -1.850944e-04 -1.936144e-04
## ASV0678     -3.458919e-04 -3.622901e-04 -3.794608e-04 -3.974395e-04
## ASV1295     -2.406815e-04 -2.517307e-04 -2.632684e-04 -2.753145e-04
## ASV7517     -1.449723e-04 -1.512787e-04 -1.578326e-04 -1.646414e-04
## ASV2996     -4.679576e-04 -4.891228e-04 -5.111936e-04 -5.342040e-04
## ASV2882     -4.391730e-04 -4.588909e-04 -4.794408e-04 -5.008531e-04
## ASV1317      2.715263e-04  2.840372e-04  2.971039e-04  3.107490e-04
## ASV9106     -4.482726e-04 -4.688347e-04 -4.903035e-04 -5.127155e-04
## ASV9688     -4.265347e-04 -4.460818e-04 -4.664886e-04 -4.877894e-04
## ASV6181     -4.254223e-04 -4.448451e-04 -4.651159e-04 -4.862680e-04
## ASV2936      1.317332e-05  1.391826e-05  1.470843e-05  1.554673e-05
## ASV0192     -1.743465e-04 -1.819557e-04 -1.898633e-04 -1.980780e-04
## ASV2509     -2.162228e-04 -2.264808e-04 -2.372209e-04 -2.484652e-04
## ASV0863      7.409957e-04  7.738131e-04  8.079738e-04  8.435230e-04
## ASV2762     -1.917380e-04 -2.005638e-04 -2.097828e-04 -2.194116e-04
## ASV4904     -4.076051e-04 -4.262172e-04 -4.456422e-04 -4.659121e-04
## ASV0571      1.387058e-04  1.448972e-04  1.513491e-04  1.580713e-04
## ASV13304    -6.679067e-05 -7.031892e-05 -7.404375e-05 -7.797659e-05
## ASV6863     -9.261872e-05 -9.688888e-05 -1.013507e-04 -1.060123e-04
## ASV4844      3.585526e-05  3.796260e-05  4.020554e-05  4.259345e-05
## ASV10779    -4.469975e-04 -4.672794e-04 -4.884350e-04 -5.104980e-04
## ASV7921     -3.779160e-04 -3.952439e-04 -4.133356e-04 -4.322219e-04
## ASV8458     -3.928526e-04 -4.104812e-04 -4.288513e-04 -4.479896e-04
## ASV2593     -5.159069e-05 -5.348861e-05 -5.542747e-05 -5.740512e-05
## ASV4410     -2.144450e-04 -2.243271e-04 -2.346485e-04 -2.454273e-04
## ASV0593      5.520133e-04  5.778706e-04  6.049131e-04  6.331925e-04
## ASV2669      3.191546e-04  3.333237e-04  3.480741e-04  3.634253e-04
## ASV0868     -4.210035e-04 -4.402890e-04 -4.604226e-04 -4.814382e-04
## ASV3123     -1.496213e-04 -1.567924e-04 -1.643045e-04 -1.721733e-04
## ASV3482     -1.709721e-04 -1.786852e-04 -1.867261e-04 -1.951068e-04
## ASV2552     -4.697916e-04 -4.902717e-04 -5.115606e-04 -5.336829e-04
## ASV0723      5.351718e-04  5.585599e-04  5.828770e-04  6.081520e-04
## ASV0526     -3.581242e-04 -3.745153e-04 -3.916279e-04 -4.094912e-04
## ASV4623     -1.621843e-04 -1.697111e-04 -1.775773e-04 -1.857974e-04
## ASV2070     -4.989066e-04 -5.216491e-04 -5.453814e-04 -5.701424e-04
## ASV1198      1.243415e-05  1.293158e-05  1.344421e-05  1.397202e-05
## ASV3034      2.028896e-05  2.107535e-05  2.188439e-05  2.271607e-05
## ASV1208     -5.910246e-05 -6.177299e-05 -6.455824e-05 -6.746267e-05
## ASV4860      8.135622e-05  8.518267e-05  8.918538e-05  9.337198e-05
## ASV2493     -1.545997e-04 -1.616751e-04 -1.690617e-04 -1.767719e-04
## ASV4217     -1.052547e-04 -1.097283e-04 -1.143663e-04 -1.191723e-04
## ASV1516     -6.996724e-05 -7.376428e-05 -7.778244e-05 -8.203551e-05
## ASV1186      1.846724e-04  1.931385e-04  2.019778e-04  2.112052e-04
## ASV1906     -1.609086e-04 -1.683542e-04 -1.761346e-04 -1.842638e-04
## ASV8220     -2.627660e-05 -2.774459e-05 -2.930162e-05 -3.095353e-05
## ASV4227     -3.659602e-04 -3.826584e-04 -4.000849e-04 -4.182686e-04
## ASV1013      2.315661e-04  2.425960e-04  2.541468e-04  2.662423e-04
## ASV7952     -2.503018e-04 -2.622300e-04 -2.747242e-04 -2.878108e-04
## ASV5923     -2.833638e-04 -2.965094e-04 -3.102480e-04 -3.246049e-04
## ASV0190     -3.494950e-04 -3.651429e-04 -3.814456e-04 -3.984264e-04
## ASV0491     -3.961597e-05 -4.171768e-05 -4.393784e-05 -4.628353e-05
## ASV9535     -1.509053e-04 -1.578078e-04 -1.650120e-04 -1.725297e-04
## ASV9947     -1.150815e-04 -1.208531e-04 -1.269238e-04 -1.333096e-04
## ASV6518     -9.862862e-05 -1.031382e-04 -1.078457e-04 -1.127590e-04
## ASV1741     -1.020226e-04 -1.068364e-04 -1.118745e-04 -1.171468e-04
## ASV1874      1.894843e-04  1.977747e-04  2.063932e-04  2.153496e-04
## ASV2150      5.439908e-05  5.692012e-05  5.955459e-05  6.230725e-05
## ASV5262     -9.997560e-05 -1.044335e-04 -1.090763e-04 -1.139106e-04
## ASV1729     -3.625842e-04 -3.793206e-04 -3.968048e-04 -4.150678e-04
## ASV1522     -7.212360e-05 -7.593709e-05 -7.995946e-05 -8.420216e-05
## ASV3250      7.679764e-05  8.016410e-05  8.366512e-05  8.730494e-05
## ASV4338     -3.656972e-04 -3.824325e-04 -3.999023e-04 -4.181361e-04
## ASV1386      4.370328e-04  4.571307e-04  4.781194e-04  5.000353e-04
## ASV0694     -5.039538e-05 -5.295556e-05 -5.565178e-05 -5.849166e-05
## ASV2026      4.089411e-05  4.317240e-05  4.558706e-05  4.814673e-05
## ASV0191     -2.894007e-04 -3.022546e-04 -3.156365e-04 -3.295641e-04
## ASV1641      1.424651e-04  1.491985e-04  1.562443e-04  1.636162e-04
## ASV1326      7.075674e-04  7.398660e-04  7.735738e-04  8.087464e-04
## ASV4786     -2.171530e-05 -2.283645e-05 -2.401859e-05 -2.526521e-05
## ASV0342      1.787905e-04  1.872035e-04  1.960064e-04  2.052165e-04
## ASV3025     -2.046656e-04 -2.137342e-04 -2.231746e-04 -2.329992e-04
## ASV6533     -3.515469e-04 -3.672909e-04 -3.836951e-04 -4.007834e-04
## ASV1898      3.957825e-04  4.140161e-04  4.330582e-04  4.529414e-04
## ASV1940      2.242213e-04  2.344908e-04  2.452105e-04  2.563982e-04
## ASV4968     -4.098080e-04 -4.286941e-04 -4.484213e-04 -4.690241e-04
## ASV3401     -2.144906e-04 -2.242847e-04 -2.345069e-04 -2.451742e-04
## ASV3211      1.299733e-04  1.361881e-04  1.426988e-04  1.495191e-04
## ASV1489     -5.680113e-04 -5.938562e-04 -6.208202e-04 -6.489466e-04
## ASV4139     -3.333830e-04 -3.486502e-04 -3.645885e-04 -3.812248e-04
## ASV6059     -3.519158e-04 -3.680490e-04 -3.848934e-04 -4.024777e-04
## ASV0918      8.791358e-05  9.168250e-05  9.559393e-05  9.965157e-05
## ASV1449      3.418898e-04  3.575458e-04  3.738898e-04  3.909496e-04
## ASV5652     -2.348687e-04 -2.455942e-04 -2.567880e-04 -2.684685e-04
## ASV4091     -5.452733e-06 -5.185064e-06 -4.858975e-06 -4.468014e-06
## ASV7638     -2.173756e-04 -2.271215e-04 -2.372765e-04 -2.478553e-04
## ASV6525     -3.052445e-04 -3.187169e-04 -3.327386e-04 -3.473280e-04
## ASV8959     -3.180431e-04 -3.326867e-04 -3.479809e-04 -3.639525e-04
## ASV0699      2.425738e-04  2.536132e-04  2.651276e-04  2.771346e-04
## ASV2925      2.983908e-04  3.122083e-04  3.266469e-04  3.417326e-04
## ASV0618      6.658748e-05  6.984154e-05  7.325508e-05  7.683566e-05
## ASV2083      4.664111e-05  4.894949e-05  5.137482e-05  5.392316e-05
## ASV6192     -3.866901e-04 -4.042595e-04 -4.225878e-04 -4.417044e-04
## ASV8640     -4.372732e-04 -4.571653e-04 -4.779197e-04 -4.995698e-04
## ASV1103      1.788081e-04  1.867753e-04  1.950735e-04  2.037146e-04
## ASV4240     -1.983841e-05 -2.034779e-05 -2.084460e-05 -2.132540e-05
## ASV2180      1.137493e-04  1.189057e-04  1.242843e-04  1.298936e-04
## ASV9157     -2.801472e-04 -2.928488e-04 -3.060963e-04 -3.199103e-04
## ASV1307      5.515201e-04  5.769243e-04  6.034585e-04  6.311695e-04
## ASV4960     -1.365253e-04 -1.425575e-04 -1.488353e-04 -1.553669e-04
## ASV3930     -1.162721e-04 -1.214239e-04 -1.267875e-04 -1.323703e-04
## ASV1200     -2.414359e-04 -2.525804e-04 -2.642221e-04 -2.763816e-04
## ASV4676     -1.223697e-04 -1.279319e-04 -1.337348e-04 -1.397876e-04
## ASV6993     -4.537406e-04 -4.740995e-04 -4.953147e-04 -5.174171e-04
## ASV4813     -1.780771e-04 -1.861911e-04 -1.946573e-04 -2.034896e-04
## ASV4364     -5.855272e-04 -6.118842e-04 -6.393581e-04 -6.679899e-04
## ASV0141      2.303239e-04  2.400913e-04  2.502195e-04  2.607173e-04
## ASV3509      1.493622e-04  1.566273e-04  1.642513e-04  1.722521e-04
## ASV2751      2.479486e-04  2.593488e-04  2.712543e-04  2.836860e-04
## ASV4913     -2.533709e-04 -2.648403e-04 -2.768020e-04 -2.892748e-04
## ASV0138      6.284700e-04  6.571289e-04  6.870377e-04  7.182459e-04
## ASV7697     -1.756826e-04 -1.834310e-04 -1.914927e-04 -1.998779e-04
## ASV1602      8.872302e-05  9.230299e-05  9.599646e-05  9.980408e-05
## ASV5976     -3.519832e-04 -3.679875e-04 -3.846851e-04 -4.021030e-04
## ASV7525     -3.624419e-04 -3.788840e-04 -3.960349e-04 -4.139218e-04
## ASV4961      1.636729e-04  1.710646e-04  1.787704e-04  1.868017e-04
## ASV2546      4.396092e-04  4.588971e-04  4.789590e-04  4.998199e-04
## ASV0721     -2.671420e-04 -2.792765e-04 -2.919343e-04 -3.051355e-04
## ASV0542      2.453850e-04  2.565120e-04  2.681186e-04  2.802233e-04
## ASV3865      1.565670e-04  1.635312e-04  1.707826e-04  1.783312e-04
## ASV5571     -2.830337e-04 -2.954316e-04 -3.083233e-04 -3.217238e-04
## ASV6804      3.672304e-05  3.872197e-05  4.083788e-05  4.307811e-05
## ASV4424      2.642176e-04  2.763309e-04  2.889763e-04  3.021751e-04
## ASV3395      1.915512e-04  1.996487e-04  2.080436e-04  2.167432e-04
## ASV2394     -2.606220e-04 -2.725947e-04 -2.850973e-04 -2.981513e-04
## ASV8629     -2.605963e-04 -2.725667e-04 -2.850666e-04 -2.981178e-04
## ASV1018      2.358448e-04  2.466419e-04  2.579137e-04  2.696794e-04
## ASV6139     -5.277515e-04 -5.518544e-04 -5.770098e-04 -6.032592e-04
## ASV10411    -2.709323e-04 -2.833720e-04 -2.963615e-04 -3.099232e-04
## ASV3992     -1.056398e-04 -1.105802e-04 -1.157474e-04 -1.211515e-04
## ASV7131     -2.094287e-05 -2.194556e-05 -2.299681e-05 -2.409905e-05
## ASV3729     -4.331126e-05 -4.499849e-05 -4.673214e-05 -4.851147e-05
## ASV2197     -5.791635e-05 -6.048655e-05 -6.316258e-05 -6.594809e-05
## ASV2426     -2.710109e-04 -2.831230e-04 -2.957404e-04 -3.088812e-04
## ASV3669     -2.556590e-04 -2.676615e-04 -2.802193e-04 -2.933572e-04
## ASV1820      1.338704e-04  1.398902e-04  1.461639e-04  1.527005e-04
## ASV7081     -2.412677e-04 -2.523706e-04 -2.639672e-04 -2.760779e-04
## ASV7872     -3.057216e-04 -3.195207e-04 -3.339079e-04 -3.489051e-04
## ASV1670     -3.613993e-05 -3.755356e-05 -3.900691e-05 -4.049952e-05
## ASV0712      2.985954e-04  3.128519e-04  3.277867e-04  3.434317e-04
## ASV0474      4.513472e-04  4.708702e-04  4.911517e-04  5.122137e-04
## ASV1196      4.512428e-04  4.719450e-04  4.935605e-04  5.161262e-04
## ASV0845      2.830103e-04  2.957859e-04  3.091079e-04  3.229968e-04
## ASV12393    -5.752795e-04 -6.016496e-04 -6.291800e-04 -6.579170e-04
## ASV5867     -2.216148e-04 -2.318426e-04 -2.425260e-04 -2.536837e-04
## ASV17619    -8.454437e-05 -8.869045e-05 -9.304424e-05 -9.761644e-05
## ASV4686     -1.958783e-04 -2.049716e-04 -2.144763e-04 -2.244102e-04
## ASV3520     -3.181233e-04 -3.326440e-04 -3.477987e-04 -3.636127e-04
## ASV10800    -5.206388e-04 -5.445880e-04 -5.695993e-04 -5.957161e-04
## ASV2706      4.622908e-04  4.836610e-04  5.059879e-04  5.293114e-04
## ASV1227     -6.400770e-05 -6.680063e-05 -6.970379e-05 -7.272050e-05
## ASV2621      4.255242e-04  4.454963e-04  4.663906e-04  4.882480e-04
## ASV0460      9.546020e-05  1.000612e-04  1.048849e-04  1.099421e-04
## ASV1069     -3.473728e-04 -3.634816e-04 -3.803167e-04 -3.979088e-04
## ASV6939     -3.192981e-04 -3.337372e-04 -3.487944e-04 -3.644931e-04
## ASV2862     -4.442675e-04 -4.645218e-04 -4.856578e-04 -5.077101e-04
## ASV1021     -2.595666e-04 -2.711163e-04 -2.831429e-04 -2.956630e-04
## ASV3845      2.067915e-04  2.163296e-04  2.262918e-04  2.366955e-04
## ASV0732      1.818585e-04  1.904270e-04  1.993938e-04  2.087766e-04
## ASV10731     1.391912e-04  1.454483e-04  1.519692e-04  1.587636e-04
## ASV3378      1.651647e-04  1.723022e-04  1.797149e-04  1.874107e-04
## ASV7154      1.211333e-05  1.229540e-05  1.245073e-05  1.257503e-05
## ASV9876      7.804100e-05  8.175001e-05  8.563398e-05  8.970094e-05
## ASV0631      3.493736e-04  3.657192e-04  3.828154e-04  4.006954e-04
## ASV13027    -2.640588e-04 -2.763540e-04 -2.892085e-04 -3.026467e-04
## ASV2497     -2.640325e-04 -2.763251e-04 -2.891769e-04 -3.026120e-04
## ASV3966     -3.724792e-04 -3.898675e-04 -4.080508e-04 -4.270639e-04
## ASV2574      2.199026e-04  2.295318e-04  2.395437e-04  2.499497e-04
## ASV0545     -2.069551e-04 -2.166607e-04 -2.268120e-04 -2.374283e-04
## ASV8453     -2.343571e-04 -2.452577e-04 -2.566535e-04 -2.685658e-04
## ASV0221     -1.238030e-04 -1.295217e-04 -1.354964e-04 -1.417379e-04
## ASV3305      1.678504e-04  1.757812e-04  1.840832e-04  1.927734e-04
## ASV2647     -1.145430e-04 -1.196179e-04 -1.249000e-04 -1.303964e-04
## ASV5789     -5.347342e-04 -5.596952e-04 -5.857974e-04 -6.130909e-04
## ASV1731     -1.668173e-04 -1.739274e-04 -1.813038e-04 -1.889535e-04
## ASV3857      7.437443e-05  7.767703e-05  8.111576e-05  8.469532e-05
## ASV0405      3.123441e-04  3.261543e-04  3.405265e-04  3.554792e-04
## ASV0094     -3.555436e-04 -3.707053e-04 -3.864398e-04 -4.027629e-04
## ASV0158     -1.200236e-05 -1.225928e-05 -1.250306e-05 -1.273123e-05
## ASV5507     -3.143771e-04 -3.287580e-04 -3.437699e-04 -3.594382e-04
## ASV1023     -1.206518e-06 -8.013023e-07 -3.350883e-07  1.986228e-07
## ASV0488     -2.045794e-04 -2.139756e-04 -2.237869e-04 -2.340301e-04
## ASV1459      1.706078e-04  1.780699e-04  1.858300e-04  1.938975e-04
## ASV4349     -5.082359e-05 -5.290730e-05 -5.506090e-05 -5.728535e-05
## ASV1172      5.291896e-04  5.531187e-04  5.780714e-04  6.040861e-04
## ASV10187    -1.399289e-04 -1.465524e-04 -1.534871e-04 -1.607473e-04
## ASV7227      8.264654e-05  8.651376e-05  9.055872e-05  9.478929e-05
## ASV10340     8.132576e-05  8.521858e-05  8.929840e-05  9.357424e-05
## ASV10821    -1.500924e-04 -1.569386e-04 -1.640828e-04 -1.715366e-04
## ASV13810    -1.500777e-04 -1.569226e-04 -1.640652e-04 -1.715174e-04
## ASV3230     -1.205878e-04 -1.261069e-04 -1.318679e-04 -1.378802e-04
## ASV5524      1.215881e-05  1.259073e-05  1.303022e-05  1.347658e-05
## ASV8742     -1.500520e-04 -1.568945e-04 -1.640345e-04 -1.714838e-04
## ASV9188      3.297759e-04  3.443317e-04  3.594769e-04  3.752306e-04
## ASV4658      1.680083e-04  1.756907e-04  1.837089e-04  1.920763e-04
## ASV7889      2.030721e-04  2.119051e-04  2.210866e-04  2.306274e-04
## ASV1466      4.899993e-05  5.165937e-05  5.447298e-05  5.745023e-05
## ASV1424     -9.418450e-05 -9.772525e-05 -1.013514e-04 -1.050600e-04
## ASV0098     -2.592257e-04 -2.713022e-04 -2.839265e-04 -2.971218e-04
## ASV0067     -4.132955e-04 -4.321942e-04 -4.519202e-04 -4.725065e-04
## ASV9434     -1.714045e-04 -1.791823e-04 -1.872953e-04 -1.957561e-04
## ASV3270     -6.825446e-05 -7.150714e-05 -7.491341e-05 -7.848024e-05
## ASV4518     -2.932418e-04 -3.064292e-04 -3.201739e-04 -3.344962e-04
## ASV7661     -2.750176e-04 -2.871319e-04 -2.997352e-04 -3.128434e-04
## ASV4223      3.173092e-05  3.322343e-05  3.478423e-05  3.641617e-05
## ASV3481      2.384118e-04  2.500538e-04  2.622748e-04  2.751040e-04
## ASV7819     -4.340103e-04 -4.538477e-04 -4.745540e-04 -4.961640e-04
## ASV3095     -1.822259e-05 -1.895856e-05 -1.971700e-05 -2.049779e-05
## ASV4476     -8.964344e-05 -9.389353e-05 -9.834388e-05 -1.030038e-04
## ASV1713      2.600486e-04  2.714134e-04  2.832294e-04  2.955105e-04
## ASV11165    -6.768867e-05 -7.056156e-05 -7.353940e-05 -7.662442e-05
## ASV2179      5.379348e-04  5.625930e-04  5.883366e-04  6.152093e-04
## ASV3747      4.610792e-04  4.821851e-04  5.042166e-04  5.272106e-04
## ASV1410      2.381950e-05  2.461177e-05  2.541244e-05  2.621956e-05
## ASV6069     -2.897213e-04 -3.030085e-04 -3.168816e-04 -3.313645e-04
## ASV1939      8.101681e-05  8.492609e-05  8.902522e-05  9.332340e-05
## ASV7865     -4.514083e-04 -4.720556e-04 -4.936071e-04 -5.160986e-04
## ASV4488     -4.156823e-04 -4.349493e-04 -4.550844e-04 -4.761243e-04
## ASV0938      3.277812e-04  3.426954e-04  3.582562e-04  3.744886e-04
## ASV7852     -2.483417e-04 -2.594743e-04 -2.710754e-04 -2.831621e-04
## ASV2503     -2.407215e-05 -2.543383e-05 -2.688053e-05 -2.841813e-05
## ASV2993     -3.558328e-04 -3.722834e-04 -3.894707e-04 -4.074255e-04
## ASV3752     -4.364586e-05 -4.557882e-05 -4.759086e-05 -4.968467e-05
## ASV2557     -3.625694e-04 -3.793459e-04 -3.968731e-04 -4.151821e-04
## ASV6522     -7.448300e-05 -7.777436e-05 -8.119937e-05 -8.476242e-05
## ASV0088     -2.667298e-04 -2.782044e-04 -2.901173e-04 -3.024805e-04
## ASV7935     -2.239216e-04 -2.340859e-04 -2.446888e-04 -2.557472e-04
## ASV0942     -2.859148e-04 -2.991477e-04 -3.129741e-04 -3.274188e-04
## ASV7709     -3.328821e-04 -3.476614e-04 -3.630481e-04 -3.790629e-04
## ASV4588     -1.698984e-04 -1.772579e-04 -1.849041e-04 -1.928456e-04
## ASV5765     -4.761820e-04 -4.978610e-04 -5.204805e-04 -5.440772e-04
## ASV3562     -2.352099e-05 -2.430381e-05 -2.509352e-05 -2.588783e-05
## ASV9076     -3.644306e-04 -3.811377e-04 -3.985808e-04 -4.167898e-04
## ASV4707     -4.067729e-04 -4.254777e-04 -4.450114e-04 -4.654077e-04
## ASV2188      2.902479e-04  3.038047e-04  3.179820e-04  3.328068e-04
## ASV0613      5.468921e-05  5.747572e-05  6.040806e-05  6.349388e-05
## ASV0663     -1.834415e-04 -1.919135e-04 -2.007645e-04 -2.100101e-04
## ASV3361     -3.603580e-04 -3.758271e-04 -3.918862e-04 -4.085512e-04
## ASV1478      4.026612e-04  4.207939e-04  4.396953e-04  4.593938e-04
## ASV0213      2.238297e-04  2.339542e-04  2.445122e-04  2.555201e-04
## ASV7674     -1.222447e-04 -1.276942e-04 -1.333702e-04 -1.392808e-04
## ASV2137     -1.308814e-04 -1.366600e-04 -1.426728e-04 -1.489275e-04
## ASV8246     -1.092920e-04 -1.142046e-04 -1.193252e-04 -1.246615e-04
## ASV0047     -3.461099e-04 -3.615582e-04 -3.776490e-04 -3.944052e-04
## ASV6117      1.232655e-05  1.304436e-05  1.380701e-05  1.461739e-05
## ASV3349     -6.639494e-05 -6.943886e-05 -7.261677e-05 -7.593405e-05
## ASV10881    -2.275148e-04 -2.379237e-04 -2.487885e-04 -2.601271e-04
## ASV6979     -1.540674e-04 -1.612269e-04 -1.687103e-04 -1.765315e-04
## ASV7930     -2.972200e-04 -3.107297e-04 -3.248241e-04 -3.395257e-04
## ASV7322      9.997986e-05  1.045919e-04  1.094093e-04  1.144406e-04
## ASV4927     -5.086230e-05 -5.332932e-05 -5.591700e-05 -5.863121e-05
## ASV9054     -1.657768e-04 -1.732372e-04 -1.810145e-04 -1.891205e-04
## ASV2692     -1.301092e-04 -1.364308e-04 -1.430579e-04 -1.500045e-04
## ASV1666     -8.687881e-05 -9.041156e-05 -9.405922e-05 -9.782282e-05
## ASV4728      1.900925e-04  1.985251e-04  2.073051e-04  2.164446e-04
## ASV3097      1.278179e-04  1.338327e-04  1.401269e-04  1.467130e-04
## ASV4962     -1.036597e-04 -1.088116e-04 -1.142258e-04 -1.199159e-04
## ASV5057      1.569049e-04  1.643405e-04  1.721263e-04  1.802786e-04
## ASV2639      2.835877e-04  2.969536e-04  3.109412e-04  3.255784e-04
## ASV1808     -3.566662e-05 -3.787011e-05 -4.021995e-05 -4.272613e-05
## ASV6333     -5.438541e-05 -5.721563e-05 -6.020139e-05 -6.335175e-05
## ASV4328     -1.263113e-04 -1.320677e-04 -1.380742e-04 -1.443409e-04
## ASV7707     -3.710798e-04 -3.877610e-04 -4.051459e-04 -4.232602e-04
## ASV11022    -3.598355e-04 -3.759517e-04 -3.927432e-04 -4.102341e-04
## ASV1469     -6.728794e-05 -7.030242e-05 -7.344378e-05 -7.671671e-05
## ASV3919     -1.251785e-04 -1.311029e-04 -1.373043e-04 -1.437953e-04
## ASV4038     -2.522972e-04 -2.637522e-04 -2.757018e-04 -2.881653e-04
## ASV4048      9.135034e-05  9.583200e-05  1.005370e-04  1.054764e-04
## ASV0634      1.048284e-04  1.097573e-04  1.149156e-04  1.203136e-04
## ASV1852     -2.861702e-04 -2.997438e-04 -3.139563e-04 -3.288371e-04
## ASV2505      2.138435e-04  2.235815e-04  2.337436e-04  2.443468e-04
## ASV1762     -3.280259e-04 -3.428957e-04 -3.584054e-04 -3.745794e-04
## ASV3761     -2.785107e-04 -2.911752e-04 -3.043879e-04 -3.181701e-04
## ASV0775     -4.721942e-04 -4.936164e-04 -5.159612e-04 -5.392640e-04
## ASV10911    -3.461114e-04 -3.617713e-04 -3.781025e-04 -3.951306e-04
## ASV1339     -5.852982e-05 -6.108223e-05 -6.373453e-05 -6.648954e-05
## ASV5214     -7.852380e-05 -8.197877e-05 -8.557220e-05 -8.930836e-05
## ASV4945      9.184276e-05  9.608656e-05  1.005196e-04  1.051496e-04
## ASV5624     -7.365364e-05 -7.669086e-05 -7.983081e-05 -8.307484e-05
## ASV3429     -4.205559e-05 -4.380024e-05 -4.560657e-05 -4.747592e-05
## ASV8416     -4.117707e-05 -4.339560e-05 -4.574105e-05 -4.822099e-05
## ASV2400     -4.276023e-04 -4.471317e-04 -4.675143e-04 -4.887839e-04
## ASV3388     -1.402649e-04 -1.469067e-04 -1.538599e-04 -1.611385e-04
## ASV7089      8.600733e-05  8.965286e-05  9.343159e-05  9.734642e-05
## ASV3396     -1.418722e-04 -1.481692e-04 -1.547236e-04 -1.615439e-04
## ASV0343      2.060907e-04  2.161518e-04  2.267112e-04  2.377936e-04
## ASV5505     -2.598352e-04 -2.718895e-04 -2.844881e-04 -2.976543e-04
## ASV6721     -1.230665e-04 -1.289073e-04 -1.350237e-04 -1.414285e-04
## ASV0537      1.094676e-04  1.152540e-04  1.213635e-04  1.278150e-04
## ASV7753     -3.364756e-04 -3.519316e-04 -3.680713e-04 -3.849224e-04
## ASV5022     -2.835944e-05 -3.000148e-05 -3.174565e-05 -3.359854e-05
## ASV1073      4.701208e-04  4.917369e-04  5.143107e-04  5.378814e-04
## ASV1347     -1.357179e-06 -1.498020e-06 -1.653603e-06 -1.825471e-06
## ASV15032     1.409942e-04  1.471700e-04  1.535905e-04  1.602631e-04
## ASV18213    -1.367878e-06 -1.509657e-06 -1.666254e-06 -1.839219e-06
## ASV20691     1.206056e-04  1.262374e-04  1.321256e-04  1.382813e-04
## ASV4260     -6.189205e-05 -6.476083e-05 -6.776010e-05 -7.089567e-05
## ASV4923      1.047106e-04  1.095887e-04  1.146876e-04  1.200168e-04
## ASV7995     -1.381918e-06 -1.525017e-06 -1.683055e-06 -1.857591e-06
## ASV8960      2.101968e-04  2.197381e-04  2.296894e-04  2.400664e-04
## ASV10682     1.579972e-04  1.647279e-04  1.717083e-04  1.789443e-04
## ASV11911    -1.408242e-06 -1.553701e-06 -1.714301e-06 -1.891615e-06
## ASV14296     2.519345e-04  2.631271e-04  2.747788e-04  2.869051e-04
## ASV2314      1.472928e-04  1.546325e-04  1.623476e-04  1.704579e-04
## ASV3819      1.626432e-04  1.698721e-04  1.773971e-04  1.852279e-04
## ASV4517     -1.448588e-06 -1.597793e-06 -1.762477e-06 -1.944242e-06
## ASV8941      3.131776e-04  3.276708e-04  3.428144e-04  3.586356e-04
## ASV1444      1.467727e-06  1.618728e-06  1.785371e-06  1.969273e-06
## ASV5959      5.677017e-05  5.929703e-05  6.192688e-05  6.466291e-05
## ASV3623     -1.437939e-04 -1.502206e-04 -1.569164e-04 -1.638911e-04
## ASV0260      1.745333e-04  1.825991e-04  1.910264e-04  1.998302e-04
## ASV4401     -1.175259e-04 -1.234992e-04 -1.297810e-04 -1.363868e-04
## ASV2891     -3.810696e-04 -3.987253e-04 -4.171761e-04 -4.364558e-04
## ASV2778     -8.565453e-05 -8.959867e-05 -9.371816e-05 -9.802024e-05
## ASV8744      1.659990e-04  1.731896e-04  1.806615e-04  1.884232e-04
## ASV1079      3.420378e-04  3.571241e-04  3.728239e-04  3.891579e-04
## ASV19688     2.698117e-05  2.847952e-05  3.006774e-05  3.175160e-05
## ASV4039      4.398032e-05  4.631251e-05  4.877645e-05  5.138009e-05
## ASV4982     -2.579863e-04 -2.697162e-04 -2.819542e-04 -2.947200e-04
## ASV1071     -2.579612e-04 -2.696887e-04 -2.819241e-04 -2.946872e-04
## ASV7666     -2.579360e-04 -2.696612e-04 -2.818941e-04 -2.946544e-04
## ASV0502      3.615326e-04  3.781232e-04  3.954459e-04  4.135303e-04
## ASV3624     -2.583918e-04 -2.701532e-04 -2.824247e-04 -2.952262e-04
## ASV0403      3.612098e-05  3.759979e-05  3.912831e-05  4.070724e-05
## ASV4939     -2.583639e-04 -2.701227e-04 -2.823914e-04 -2.951898e-04
## ASV6297     -3.102228e-04 -3.245217e-04 -3.394570e-04 -3.550550e-04
## ASV6343      2.728195e-04  2.845154e-04  2.966564e-04  3.092548e-04
## ASV0954     -5.673115e-05 -5.895303e-05 -6.123753e-05 -6.358394e-05
## ASV10225    -1.134446e-04 -1.187964e-04 -1.243952e-04 -1.302515e-04
## ASV1584      4.492961e-04  4.697527e-04  4.910970e-04  5.133635e-04
## ASV1803      1.635469e-04  1.706352e-04  1.779974e-04  1.856410e-04
## ASV2576     -4.492403e-04 -4.696917e-04 -4.910304e-04 -5.132909e-04
## ASV3252      2.927393e-04  3.061999e-04  3.202566e-04  3.349335e-04
## ASV3463     -4.491942e-04 -4.696413e-04 -4.909754e-04 -5.132308e-04
## ASV3822     -3.428556e-04 -3.587792e-04 -3.754239e-04 -3.928208e-04
## ASV4926     -1.794761e-04 -1.871415e-04 -1.950938e-04 -2.033400e-04
## ASV5564     -1.161517e-04 -1.214495e-04 -1.269785e-04 -1.327481e-04
## ASV5595     -6.770845e-05 -7.077639e-05 -7.397665e-05 -7.731438e-05
## ASV16463    -2.625612e-04 -2.747180e-04 -2.874218e-04 -3.006957e-04
## ASV6277      2.630735e-04  2.754253e-04  2.883464e-04  3.018618e-04
## ASV1344      2.625491e-04  2.747047e-04  2.874072e-04  3.006798e-04
## ASV1869      1.657254e-04  1.729505e-04  1.804590e-04  1.882592e-04
## ASV8155     -1.418576e-04 -1.479880e-04 -1.543545e-04 -1.609638e-04
## ASV2502     -2.640842e-04 -2.760443e-04 -2.885176e-04 -3.015234e-04
## ASV6742     -8.117139e-05 -8.454796e-05 -8.804263e-05 -9.165753e-05
## ASV3124     -1.714572e-04 -1.792177e-04 -1.873134e-04 -1.957577e-04
## ASV17042    -3.005382e-04 -3.142038e-04 -3.284605e-04 -3.433312e-04
## ASV0248      4.158448e-04  4.345510e-04  4.540496e-04  4.743698e-04
## ASV4557      7.293579e-05  7.675426e-05  8.078054e-05  8.502605e-05
## ASV3507     -4.581391e-04 -4.792810e-04 -5.013665e-04 -5.244350e-04
## ASV1870      3.362008e-05  3.516145e-05  3.677065e-05  3.845039e-05
## ASV2447     -2.213109e-04 -2.316642e-04 -2.424938e-04 -2.538211e-04
## ASV0347      3.589213e-04  3.756103e-04  3.930566e-04  4.112931e-04
## ASV1855     -1.644477e-04 -1.720362e-04 -1.799637e-04 -1.882446e-04
## ASV0568      1.231118e-04  1.286723e-04  1.344705e-04  1.405153e-04
## ASV1620     -2.199105e-04 -2.299941e-04 -2.405217e-04 -2.515111e-04
## ASV0101     -1.751545e-04 -1.825534e-04 -1.902228e-04 -1.981690e-04
## ASV7751      1.674284e-04  1.755601e-04  1.840922e-04  1.930446e-04
## ASV9033     -3.013364e-04 -3.152737e-04 -3.298362e-04 -3.450504e-04
## ASV3438     -8.768273e-05 -9.181004e-05 -9.612945e-05 -1.006497e-04
## ASV0637     -2.808859e-04 -2.937556e-04 -3.071911e-04 -3.212153e-04
## ASV1181     -2.080166e-04 -2.176489e-04 -2.277139e-04 -2.382296e-04
## ASV13480    -2.617817e-04 -2.738572e-04 -2.864712e-04 -2.996457e-04
## ASV14220    -2.617558e-04 -2.738289e-04 -2.864402e-04 -2.996118e-04
## ASV1448     -1.914973e-04 -2.003970e-04 -2.096998e-04 -2.194229e-04
## ASV1457      1.745281e-04  1.822045e-04  1.901892e-04  1.984916e-04
## ASV1645      1.274012e-04  1.334040e-04  1.396857e-04  1.462590e-04
## ASV2300     -1.696750e-04 -1.773143e-04 -1.852767e-04 -1.935741e-04
## ASV2533      2.609898e-04  2.727053e-04  2.849135e-04  2.976320e-04
## ASV5059      6.315069e-05  6.572472e-05  6.838363e-05  7.112840e-05
## ASV8871     -2.617450e-04 -2.738170e-04 -2.864270e-04 -2.995973e-04
## ASV1289     -2.792177e-04 -2.918314e-04 -3.049838e-04 -3.186951e-04
## ASV3983     -1.199181e-04 -1.255588e-04 -1.314609e-04 -1.376358e-04
## ASV10323    -9.598329e-05 -1.007038e-04 -1.056610e-04 -1.108671e-04
## ASV13279    -2.616788e-04 -2.737445e-04 -2.863477e-04 -2.995105e-04
## ASV7149     -2.616530e-04 -2.737162e-04 -2.863167e-04 -2.994766e-04
## ASV1691      5.018027e-05  5.256685e-05  5.506737e-05  5.768737e-05
## ASV1649      1.289127e-04  1.349207e-04  1.412002e-04  1.477625e-04
## ASV10120     3.819873e-05  4.005177e-05  4.199600e-05  4.403600e-05
## ASV8285     -3.350533e-04 -3.508105e-04 -3.672959e-04 -3.845416e-04
## ASV0037     -2.876489e-04 -3.010747e-04 -3.151138e-04 -3.297928e-04
## ASV1770      7.492332e-05  7.836455e-05  8.195855e-05  8.571167e-05
## ASV2252      7.163661e-05  7.491382e-05  7.833421e-05  8.190337e-05
## ASV7580      2.877850e-04  3.005319e-04  3.137999e-04  3.276067e-04
## ASV5643     -2.646728e-04 -2.768390e-04 -2.895444e-04 -3.028109e-04
## ASV2722     -8.611408e-05 -9.034195e-05 -9.478236e-05 -9.944636e-05
## ASV2662     -1.818640e-04 -1.902928e-04 -1.991023e-04 -2.083090e-04
## ASV0479     -4.128664e-04 -4.314811e-04 -4.508881e-04 -4.711169e-04
## ASV2009     -4.333276e-04 -4.525394e-04 -4.725379e-04 -4.933494e-04
## ASV3731     -2.926055e-04 -3.057247e-04 -3.193947e-04 -3.336352e-04
## ASV5497     -3.629017e-04 -3.793974e-04 -3.966072e-04 -4.145586e-04
## ASV6647      1.530165e-05  1.581420e-05  1.633124e-05  1.685119e-05
## ASV8974     -2.671724e-04 -2.792387e-04 -2.918195e-04 -3.049340e-04
## ASV15527     2.307848e-05  2.404563e-05  2.504745e-05  2.608467e-05
## ASV6705     -1.676281e-04 -1.759332e-04 -1.846611e-04 -1.938337e-04
## ASV0354      3.427474e-04  3.584947e-04  3.749387e-04  3.921078e-04
## ASV2707      7.717935e-05  8.043813e-05  8.381507e-05  8.731270e-05
## ASV11167    -4.497554e-04 -4.702618e-04 -4.916602e-04 -5.139855e-04
## ASV6393     -3.581586e-04 -3.745584e-04 -3.916783e-04 -4.095472e-04
## ASV3808     -2.540947e-04 -2.654050e-04 -2.771846e-04 -2.894502e-04
## ASV9337      3.433980e-05  3.565161e-05  3.699636e-05  3.837304e-05
## ASV5043     -3.673805e-04 -3.841907e-04 -4.017380e-04 -4.200517e-04
## ASV4189     -9.728749e-06 -9.945148e-06 -1.014987e-05 -1.034050e-05
## ASV1304     -1.374892e-04 -1.432019e-04 -1.491149e-04 -1.552323e-04
## ASV2105     -1.926735e-04 -2.015238e-04 -2.107657e-04 -2.204153e-04
## ASV2421     -6.739292e-05 -7.057974e-05 -7.391660e-05 -7.741053e-05
## ASV3170      3.086816e-04  3.230359e-04  3.380418e-04  3.537273e-04
## ASV5036      4.121598e-04  4.309769e-04  4.506157e-04  4.711088e-04
## ASV2286      2.602435e-04  2.721826e-04  2.846487e-04  2.976632e-04
## ASV3363      2.615290e-04  2.738344e-04  2.867109e-04  3.001842e-04
## ASV5759     -2.443532e-05 -2.567447e-05 -2.697986e-05 -2.835530e-05
## ASV5440     -1.817426e-04 -1.904470e-04 -1.995684e-04 -2.091268e-04
## ASV2050      2.964930e-04  3.094288e-04  3.228727e-04  3.368393e-04
## ASV4478      2.144016e-04  2.245421e-04  2.351577e-04  2.462702e-04
## ASV5725     -2.288914e-04 -2.391911e-04 -2.499274e-04 -2.611164e-04
## ASV1600     -6.883227e-05 -7.260626e-05 -7.660111e-05 -8.083037e-05
## ASV1654     -4.076878e-04 -4.260780e-04 -4.452519e-04 -4.652388e-04
## ASV3781     -1.752691e-04 -1.830175e-04 -1.910808e-04 -1.994693e-04
## ASV7144     -1.503466e-04 -1.569472e-04 -1.638113e-04 -1.709473e-04
## ASV12710    -5.407254e-05 -5.612419e-05 -5.822742e-05 -6.038084e-05
## ASV3317      2.059398e-04  2.153275e-04  2.251256e-04  2.353506e-04
## ASV3249     -4.033951e-04 -4.217889e-04 -4.409829e-04 -4.610085e-04
## ASV0669     -2.499939e-04 -2.610095e-04 -2.724707e-04 -2.843919e-04
## ASV0893      1.484826e-04  1.551835e-04  1.621699e-04  1.694522e-04
## ASV11060    -1.484682e-04 -1.551678e-04 -1.621527e-04 -1.694334e-04
## ASV3207      5.157131e-04  5.398814e-04  5.651622e-04  5.916045e-04
## ASV3498     -1.484666e-04 -1.551660e-04 -1.621508e-04 -1.694314e-04
## ASV4358      9.424782e-05  9.853410e-05  1.030058e-04  1.076701e-04
## ASV4806      2.553810e-04  2.670176e-04  2.791594e-04  2.918261e-04
## ASV4941      1.484587e-04  1.551574e-04  1.621414e-04  1.694212e-04
## ASV6998      4.455364e-05  4.657916e-05  4.869182e-05  5.089489e-05
## ASV7327     -1.484477e-04 -1.551454e-04 -1.621282e-04 -1.694068e-04
## ASV5112      3.016855e-04  3.156743e-04  3.302924e-04  3.455659e-04
## ASV5345     -1.484212e-04 -1.551164e-04 -1.620966e-04 -1.693722e-04
## ASV8911     -1.484068e-04 -1.551007e-04 -1.620794e-04 -1.693535e-04
## ASV5061      3.474058e-04  3.632202e-04  3.797201e-04  3.969320e-04
## ASV1968     -3.135791e-05 -3.297425e-05 -3.467821e-05 -3.647482e-05
## ASV4669     -1.483803e-04 -1.550717e-04 -1.620478e-04 -1.693190e-04
## ASV6209     -5.411121e-05 -5.635097e-05 -5.866702e-05 -6.106036e-05
## ASV6938      2.945771e-04  3.077742e-04  3.215239e-04  3.358456e-04
## ASV6987      1.626593e-04  1.697057e-04  1.770252e-04  1.846255e-04
## ASV7842     -1.483732e-04 -1.550640e-04 -1.620394e-04 -1.693098e-04
## ASV17950     1.108171e-07  1.194041e-07  1.285367e-07  1.382309e-07
## ASV3380     -4.314654e-04 -4.507424e-04 -4.708230e-04 -4.917354e-04
## ASV13740    -3.702122e-04 -3.873126e-04 -4.051782e-04 -4.238408e-04
## ASV4313     -2.169765e-04 -2.269491e-04 -2.373628e-04 -2.482355e-04
## ASV3891     -2.219220e-04 -2.313250e-04 -2.410752e-04 -2.511810e-04
## ASV3322     -2.623756e-04 -2.743907e-04 -2.869342e-04 -3.000275e-04
## ASV1668     -4.577187e-05 -4.799834e-05 -5.033623e-05 -5.279148e-05
## ASV1739      1.002094e-04  1.045135e-04  1.089811e-04  1.136165e-04
## ASV3194      2.088206e-04  2.183274e-04  2.282469e-04  2.385953e-04
## ASV0071     -3.104263e-04 -3.236655e-04 -3.374011e-04 -3.516456e-04
## ASV0695      1.523686e-04  1.594900e-04  1.669342e-04  1.747146e-04
## ASV3835     -1.179418e-04 -1.231754e-04 -1.286237e-04 -1.342940e-04
## ASV1876      1.231084e-04  1.288586e-04  1.348712e-04  1.411575e-04
## ASV4892     -3.643410e-04 -3.810877e-04 -3.985761e-04 -4.168364e-04
## ASV1212     -1.252341e-04 -1.309263e-04 -1.368654e-04 -1.430612e-04
## ASV2640      1.365381e-06  1.348027e-06  1.322735e-06  1.288554e-06
## ASV7236     -3.606588e-04 -3.773417e-04 -3.947733e-04 -4.129849e-04
## ASV2353     -1.016523e-04 -1.065215e-04 -1.116246e-04 -1.169727e-04
## ASV0276      4.339895e-04  4.530249e-04  4.728245e-04  4.934133e-04
## ASV2262     -1.332963e-04 -1.393844e-04 -1.457401e-04 -1.523745e-04
## ASV11201    -9.006844e-05 -9.435756e-05 -9.884999e-05 -1.035552e-04
## ASV0665      3.569605e-05  3.726516e-05  3.889830e-05  4.059776e-05
## ASV5238      3.304750e-05  3.384342e-05  3.461021e-05  3.534117e-05
## ASV6885     -1.972280e-04 -2.061668e-04 -2.154901e-04 -2.252127e-04
## ASV1844      8.222061e-05  8.639863e-05  9.079744e-05  9.542916e-05
## ASV0379      2.572389e-04  2.688938e-04  2.810493e-04  2.937244e-04
## ASV1040     -7.959548e-05 -8.301072e-05 -8.655570e-05 -9.023389e-05
## ASV7913     -1.495048e-04 -1.563335e-04 -1.634602e-04 -1.708966e-04
## ASV1197     -2.571940e-04 -2.688448e-04 -2.809958e-04 -2.936660e-04
## ASV5918      1.118408e-04  1.169997e-04  1.223890e-04  1.280182e-04
## ASV8045      5.905012e-05  6.201749e-05  6.513819e-05  6.842025e-05
## ASV16458    -2.474605e-05 -2.564628e-05 -2.656462e-05 -2.749984e-05
## ASV10827    -2.571763e-04 -2.688256e-04 -2.809749e-04 -2.936432e-04
## ASV3658     -2.571513e-04 -2.687983e-04 -2.809451e-04 -2.936107e-04
## ASV0073     -5.355694e-04 -5.602855e-04 -5.861037e-04 -6.130694e-04
## ASV1951     -1.106261e-04 -1.162289e-04 -1.221250e-04 -1.283303e-04
## ASV7630     -3.397423e-04 -3.552228e-04 -3.713761e-04 -3.882287e-04
## ASV9449     -1.827092e-04 -1.913380e-04 -2.003689e-04 -2.098198e-04
## ASV3944      3.644606e-04  3.810101e-04  3.982754e-04  4.162843e-04
## ASV1520     -4.923707e-04 -5.145836e-04 -5.377415e-04 -5.618794e-04
## ASV0307      3.830595e-04  4.008541e-04  4.194540e-04  4.388936e-04
## ASV12731    -9.785932e-05 -1.025480e-04 -1.074624e-04 -1.126133e-04
## ASV0282      3.845914e-04  4.024563e-04  4.211297e-04  4.406460e-04
## ASV2646      3.405746e-04  3.555006e-04  3.710220e-04  3.871573e-04
## ASV3536      2.732988e-04  2.858039e-04  2.988573e-04  3.124807e-04
## ASV10089    -2.492882e-04 -2.602138e-04 -2.715754e-04 -2.833867e-04
## ASV1185      2.492648e-04  2.601883e-04  2.715477e-04  2.833565e-04
## ASV1452      2.492413e-04  2.601628e-04  2.715199e-04  2.833263e-04
## ASV1700      2.492179e-04  2.601373e-04  2.714922e-04  2.832961e-04
## ASV6948     -2.491945e-04 -2.601118e-04 -2.714644e-04 -2.832659e-04
## ASV0389     -3.258242e-04 -3.402165e-04 -3.551932e-04 -3.707735e-04
## ASV11884     4.992430e-06  5.646094e-06  6.365373e-06  7.155942e-06
## ASV23165    -2.491436e-04 -2.600564e-04 -2.714041e-04 -2.832003e-04
## ASV2841      2.491202e-04  2.600309e-04  2.713764e-04  2.831701e-04
## ASV2949      2.490968e-04  2.600055e-04  2.713486e-04  2.831399e-04
## ASV4037      2.490735e-04  2.599800e-04  2.713209e-04  2.831098e-04
## ASV4477      2.490501e-04  2.599545e-04  2.712932e-04  2.830796e-04
## ASV4496      2.490267e-04  2.599291e-04  2.712655e-04  2.830495e-04
## ASV5784     -2.490034e-04 -2.599036e-04 -2.712378e-04 -2.830193e-04
## ASV6035      7.676818e-06  8.303539e-06  8.982040e-06  9.716441e-06
## ASV6232     -2.494295e-04 -2.603483e-04 -2.717017e-04 -2.835032e-04
## ASV1818      2.489577e-04  2.598539e-04  2.711837e-04  2.829605e-04
## ASV2595      2.489343e-04  2.598285e-04  2.711560e-04  2.829304e-04
## ASV2788     -3.278286e-05 -3.423811e-05 -3.575283e-05 -3.732896e-05
## ASV5018      2.489130e-04  2.598052e-04  2.711307e-04  2.829028e-04
## ASV0127      3.414864e-04  3.573213e-04  3.738703e-04  3.911636e-04
## ASV1527      8.537306e-06  9.047174e-06  9.589685e-06  1.016698e-05
## ASV1055      1.929767e-04  2.017565e-04  2.109163e-04  2.204707e-04
## ASV4791      1.199733e-04  1.245268e-04  1.291970e-04  1.339816e-04
## ASV0859      1.373327e-04  1.434507e-04  1.498208e-04  1.564514e-04
## ASV12971    -3.683815e-04 -3.852519e-04 -4.028629e-04 -4.212439e-04
## ASV16856    -3.683454e-04 -3.852124e-04 -4.028196e-04 -4.211966e-04
## ASV7321     -3.010628e-04 -3.148767e-04 -3.292994e-04 -3.443554e-04
## ASV8780     -3.682804e-04 -3.851413e-04 -4.027419e-04 -4.211116e-04
## ASV1569      2.694745e-04  2.817352e-04  2.945274e-04  3.078718e-04
## ASV3696      4.294057e-05  4.479151e-05  4.671285e-05  4.870639e-05
## ASV0624      4.927705e-04  5.151268e-04  5.384488e-04  5.627743e-04
## ASV0495      2.993931e-04  3.127495e-04  3.266602e-04  3.411447e-04
## ASV16971    -1.504140e-04 -1.572933e-04 -1.644741e-04 -1.719683e-04
## ASV6535      8.689873e-05  9.113193e-05  9.557446e-05  1.002369e-04
## ASV1897      3.516213e-04  3.673704e-04  3.837800e-04  4.008738e-04
## ASV2631     -4.729147e-05 -4.980927e-05 -5.247011e-05 -5.528269e-05
## ASV6204      1.190528e-04  1.245939e-04  1.303861e-04  1.364400e-04
## ASV3312     -2.272380e-04 -2.376946e-04 -2.486162e-04 -2.600219e-04
## ASV3360      1.447747e-04  1.516115e-04  1.587671e-04  1.662559e-04
## ASV3907      7.054429e-05  7.391877e-05  7.745426e-05  8.115834e-05
## ASV6090      7.201465e-05  7.533732e-05  7.880733e-05  8.243058e-05
## ASV8652     -8.183698e-05 -8.538445e-05 -8.906975e-05 -9.289680e-05
## ASV11129    -1.484289e-04 -1.551308e-04 -1.621189e-04 -1.694041e-04
## ASV11073    -1.484145e-04 -1.551150e-04 -1.621017e-04 -1.693854e-04
## ASV1840      4.964186e-04  5.187403e-04  5.420044e-04  5.662450e-04
## ASV2298      1.868169e-04  1.951105e-04  2.037458e-04  2.127346e-04
## ASV2420      4.466913e-04  4.671765e-04  4.885648e-04  5.108927e-04
## ASV6474      6.167957e-05  6.462787e-05  6.771607e-05  7.095060e-05
## ASV8475     -1.483956e-04 -1.550944e-04 -1.620792e-04 -1.693609e-04
## ASV8679     -1.483812e-04 -1.550787e-04 -1.620620e-04 -1.693421e-04
## ASV6527      1.424878e-04  1.491385e-04  1.560933e-04  1.633654e-04
## ASV2504     -2.474699e-05 -2.609899e-05 -2.753010e-05 -2.904524e-05
## ASV1093     -1.578754e-04 -1.650638e-04 -1.725636e-04 -1.803867e-04
## ASV0994      2.081685e-04  2.177026e-04  2.276558e-04  2.380449e-04
## ASV0092     -3.449160e-04 -3.610269e-04 -3.778745e-04 -3.954911e-04
## ASV2619      7.837414e-05  8.204510e-05  8.588448e-05  8.989964e-05
## ASV0121      4.294104e-04  4.480861e-04  4.674940e-04  4.876555e-04
## ASV0932      1.507098e-04  1.578696e-04  1.653663e-04  1.732153e-04
## ASV5229      2.481722e-04  2.592682e-04  2.708266e-04  2.828637e-04
## ASV6737      2.546508e-04  2.663613e-04  2.785904e-04  2.913593e-04
## ASV11213    -3.558924e-04 -3.716136e-04 -3.879731e-04 -4.049918e-04
## ASV1151      7.392344e-04  7.729018e-04  8.080314e-04  8.446802e-04
## ASV3813      3.839941e-04  4.010742e-04  4.188583e-04  4.373705e-04
## ASV5566      8.312565e-05  8.751443e-05  9.214901e-05  9.704397e-05
## ASV7529     -3.558413e-04 -3.715579e-04 -3.879125e-04 -4.049260e-04
## ASV2193      5.192430e-04  5.433228e-04  5.684881e-04  5.947852e-04
## ASV2349      4.761618e-04  4.980088e-04  5.208207e-04  5.446367e-04
## ASV2387      4.139827e-04  4.321956e-04  4.511412e-04  4.708427e-04
## ASV2699      3.501544e-04  3.666298e-04  3.838703e-04  4.019102e-04
## ASV3353      4.524179e-04  4.728567e-04  4.941674e-04  5.163827e-04
## ASV3621      2.392515e-04  2.497423e-04  2.606520e-04  2.719935e-04
## ASV3848      4.341363e-05  4.549914e-05  4.768522e-05  4.997670e-05
## ASV4440      7.675916e-06  8.409028e-06  9.208689e-06  1.008056e-05
## ASV4751      4.787001e-04  5.006595e-04  5.235875e-04  5.475234e-04
## ASV5115      2.059201e-04  2.155123e-04  2.255399e-04  2.360215e-04
## ASV5850     -3.557520e-04 -3.714606e-04 -3.878064e-04 -4.048103e-04
## ASV6293      2.219322e-04  2.320862e-04  2.426853e-04  2.537470e-04
## ASV6513      9.975413e-05  1.047067e-04  1.099121e-04  1.153836e-04
## ASV7628     -3.557246e-04 -3.714307e-04 -3.877739e-04 -4.047750e-04
## ASV7658      2.203767e-04  2.306613e-04  2.414136e-04  2.526534e-04
## ASV0776     -4.194871e-04 -4.381836e-04 -4.576537e-04 -4.779242e-04
## ASV10227    -3.556945e-04 -3.713980e-04 -3.877383e-04 -4.047362e-04
## ASV11965    -3.556609e-04 -3.713613e-04 -3.876983e-04 -4.046927e-04
## ASV1270     -1.194172e-04 -1.245110e-04 -1.297945e-04 -1.352723e-04
## ASV13123    -2.679896e-04 -2.797148e-04 -2.919058e-04 -3.045768e-04
## ASV5828      3.555950e-04  3.712895e-04  3.876202e-04  4.046077e-04
## ASV5920     -3.555613e-04 -3.712529e-04 -3.875802e-04 -4.045641e-04
## ASV6071      3.419299e-04  3.577667e-04  3.743162e-04  3.916089e-04
## ASV6723     -1.566768e-05 -1.612491e-05 -1.657913e-05 -1.702826e-05
## ASV6727     -3.555190e-04 -3.712067e-04 -3.875299e-04 -4.045094e-04
## ASV7759     -3.554854e-04 -3.711701e-04 -3.874900e-04 -4.044659e-04
## ASV0733      2.569111e-05  2.694702e-05  2.826635e-05  2.965253e-05
## ASV1655     -5.629243e-05 -5.923326e-05 -6.233656e-05 -6.561186e-05
## ASV0755     -5.308668e-04 -5.546118e-04 -5.793493e-04 -6.051147e-04
## ASV0796      2.131725e-04  2.221586e-04  2.314706e-04  2.411157e-04
## ASV0878      4.621566e-04  4.831770e-04  5.051078e-04  5.279843e-04
## ASV4988     -2.870187e-04 -3.000963e-04 -3.137421e-04 -3.279782e-04
## ASV0083     -3.291949e-04 -3.444757e-04 -3.604444e-04 -3.771297e-04
## ASV0273      1.513047e-04  1.576688e-04  1.642647e-04  1.710979e-04
## ASV3076      1.085733e-04  1.136634e-04  1.189879e-04  1.245572e-04
## ASV1513      8.815672e-05  9.211455e-05  9.623879e-05  1.005354e-04
## ASV5159     -2.131952e-05 -2.210589e-05 -2.291013e-05 -2.373157e-05
## ASV3422     -2.191642e-04 -2.292959e-04 -2.398819e-04 -2.509411e-04
## ASV12230    -3.036870e-05 -3.160089e-05 -3.287275e-05 -3.418456e-05
## ASV1694      4.491252e-04  4.691250e-04  4.899549e-04  5.116442e-04
## ASV1249      1.982596e-04  2.073434e-04  2.168260e-04  2.267235e-04
## ASV1697     -1.087715e-04 -1.136167e-04 -1.186626e-04 -1.239162e-04
## ASV4408     -2.632617e-04 -2.743860e-04 -2.859197e-04 -2.978727e-04
## ASV0095     -3.406331e-04 -3.566445e-04 -3.733974e-04 -3.909248e-04
## ASV0410     -1.667925e-07 -4.190971e-07 -7.053149e-07 -1.028922e-06
## ASV4642     -4.231914e-04 -4.426148e-04 -4.628953e-04 -4.840677e-04
## ASV4560     -2.958025e-07 -4.486976e-08  2.414232e-07  5.667102e-07
## ASV7586     -1.996650e-04 -2.088832e-04 -2.185127e-04 -2.285706e-04
## ASV4144     -2.251491e-04 -2.356330e-04 -2.465933e-04 -2.580505e-04
## ASV0327     -2.423078e-04 -2.532672e-04 -2.646956e-04 -2.766106e-04
## ASV0946     -2.016171e-04 -2.102378e-04 -2.191846e-04 -2.284666e-04
## ASV3254     -2.636054e-04 -2.758502e-04 -2.886486e-04 -3.020242e-04
## ASV0349      3.796935e-04  3.971552e-04  4.153902e-04  4.344300e-04
## ASV0472     -2.305458e-04 -2.409792e-04 -2.518595e-04 -2.632033e-04
## ASV1330      2.299666e-04  2.399761e-04  2.503778e-04  2.611831e-04
## ASV2605      2.473559e-04  2.587333e-04  2.706146e-04  2.830202e-04
## ASV2846     -1.426909e-04 -1.495122e-04 -1.566589e-04 -1.641463e-04
## ASV3982     -1.157415e-04 -1.211945e-04 -1.269014e-04 -1.328734e-04
## ASV4116     -2.635590e-04 -2.757992e-04 -2.885926e-04 -3.019628e-04
## ASV6048     -1.545673e-04 -1.617916e-04 -1.693466e-04 -1.772467e-04
## ASV1146      3.165897e-04  3.310020e-04  3.460388e-04  3.617241e-04
## ASV13362     1.783752e-05  1.852337e-05  1.922731e-05  1.994897e-05
## ASV1422     -2.635246e-04 -2.757615e-04 -2.885513e-04 -3.019175e-04
## ASV3640     -2.634983e-04 -2.757328e-04 -2.885198e-04 -3.018831e-04
## ASV5404      2.035549e-04  2.124633e-04  2.217267e-04  2.313559e-04
## ASV6118     -2.634806e-04 -2.757133e-04 -2.884984e-04 -3.018596e-04
## ASV1115     -2.249186e-04 -2.353623e-04 -2.462768e-04 -2.576822e-04
## ASV0888     -4.797043e-04 -5.016344e-04 -5.245246e-04 -5.484132e-04
## ASV4620      5.769705e-05  5.939646e-05  6.108796e-05  6.276434e-05
## ASV3099      9.560950e-05  1.002243e-04  1.050633e-04  1.101372e-04
## ASV7099      4.452688e-05  4.669518e-05  4.897038e-05  5.135776e-05
## ASV5892     -3.022170e-04 -3.160721e-04 -3.305373e-04 -3.456370e-04
## ASV6978     -3.017871e-04 -3.157920e-04 -3.304297e-04 -3.457271e-04
## ASV6555     -1.056269e-04 -1.111322e-04 -1.169397e-04 -1.230668e-04
## ASV0539     -3.779955e-04 -3.950616e-04 -4.128552e-04 -4.314037e-04
## ASV4665      1.041636e-04  1.085158e-04  1.130219e-04  1.176850e-04
## ASV2210      2.245821e-04  2.341473e-04  2.440738e-04  2.543719e-04
## ASV1329      2.405666e-04  2.517472e-04  2.634330e-04  2.756456e-04
## ASV7123     -3.489341e-04 -3.651113e-04 -3.820184e-04 -3.996863e-04
## ASV1260      2.568242e-06  2.744617e-06  2.934026e-06  3.137455e-06
## ASV1011      3.578206e-04  3.747207e-04  3.924100e-04  4.109241e-04
## ASV4233      9.779993e-05  1.024068e-04  1.072279e-04  1.122727e-04
## ASV1475      3.600778e-04  3.763480e-04  3.933157e-04  4.110077e-04
## ASV6099     -4.169858e-04 -4.358274e-04 -4.554739e-04 -4.759552e-04
## ASV1428      7.369974e-06  8.770309e-06  1.032761e-05  1.205651e-05
## ASV5101     -4.609461e-04 -4.825064e-04 -5.050571e-04 -5.286418e-04
## ASV11827    -2.071015e-04 -2.166257e-04 -2.265719e-04 -2.369576e-04
## ASV13899    -2.354485e-04 -2.462669e-04 -2.575640e-04 -2.693592e-04
## ASV21259    -2.768399e-04 -2.896408e-04 -3.030158e-04 -3.169889e-04
## ASV6635     -1.376061e-04 -1.441226e-04 -1.509455e-04 -1.580888e-04
## ASV9922     -3.708831e-04 -3.879944e-04 -4.058693e-04 -4.245393e-04
## ASV2869      4.515559e-05  4.714348e-05  4.921075e-05  5.135977e-05
## ASV1740      2.409329e-04  2.518004e-04  2.631302e-04  2.749393e-04
## ASV4406     -3.746111e-04 -3.920775e-04 -4.103409e-04 -4.294359e-04
## ASV5586     -3.201085e-04 -3.351672e-04 -3.509249e-04 -3.674133e-04
## ASV3255     -1.260257e-04 -1.317520e-04 -1.377258e-04 -1.439569e-04
## ASV12281    -1.760863e-04 -1.839343e-04 -1.921086e-04 -2.006207e-04
## ASV5388     -3.462620e-04 -3.615202e-04 -3.773946e-04 -3.939051e-04
## ASV17660    -3.589107e-04 -3.754100e-04 -3.926404e-04 -4.106318e-04
## ASV0159      1.954201e-04  2.039671e-04  2.128584e-04  2.221057e-04
## ASV2734     -5.309079e-04 -5.550562e-04 -5.802507e-04 -6.065323e-04
## ASV2049      4.051643e-05  4.238832e-05  4.434451e-05  4.638863e-05
## ASV2465      2.349126e-05  2.410939e-05  2.471475e-05  2.530352e-05
## ASV2147      1.612996e-04  1.678717e-04  1.746618e-04  1.816729e-04
## ASV3113     -5.093925e-05 -5.320538e-05 -5.556400e-05 -5.801806e-05
## ASV0622     -3.776946e-04 -3.951406e-04 -4.133657e-04 -4.324020e-04
## ASV0437     -3.774678e-04 -3.946495e-04 -4.125763e-04 -4.312770e-04
## ASV6385     -4.138820e-04 -4.329460e-04 -4.528575e-04 -4.736514e-04
## ASV3699     -3.770904e-04 -3.947884e-04 -4.133044e-04 -4.326750e-04
## ASV2208      3.770525e-04  3.947468e-04  4.132588e-04  4.326251e-04
## ASV1053      8.560464e-05  8.950752e-05  9.358096e-05  9.783183e-05
## ASV8468     -8.337497e-05 -8.707619e-05 -9.092936e-05 -9.493959e-05
## ASV0951     -3.138517e-04 -3.280562e-04 -3.428699e-04 -3.583159e-04
## ASV0278      4.472247e-04  4.671305e-04  4.878592e-04  5.094391e-04
## ASV0914     -2.349988e-04 -2.456795e-04 -2.568214e-04 -2.684423e-04
## ASV0737      3.469276e-04  3.618518e-04  3.773475e-04  3.934303e-04
## ASV2038      5.051499e-04  5.277517e-04  5.512989e-04  5.758250e-04
## ASV2171      3.039760e-04  3.169397e-04  3.303891e-04  3.443368e-04
## ASV2607      3.468526e-04  3.617703e-04  3.772588e-04  3.933339e-04
## ASV3143      2.624054e-04  2.734869e-04  2.849734e-04  2.968744e-04
## ASV3187     -3.723812e-04 -3.884497e-04 -4.051379e-04 -4.224636e-04
## ASV3810      3.467637e-04  3.616736e-04  3.771538e-04  3.932198e-04
## ASV5060     -2.125266e-04 -2.214641e-04 -2.307251e-04 -2.403167e-04
## ASV5325      3.467143e-04  3.616200e-04  3.770955e-04  3.931566e-04
## ASV6905     -3.466824e-04 -3.615853e-04 -3.770578e-04 -3.931156e-04
## ASV7597     -3.466505e-04 -3.615506e-04 -3.770201e-04 -3.930747e-04
## ASV9652     -3.466186e-04 -3.615159e-04 -3.769824e-04 -3.930338e-04
## ASV2634      3.465867e-04  3.614813e-04  3.769448e-04  3.929928e-04
## ASV3065      3.465548e-04  3.614466e-04  3.769071e-04  3.929519e-04
## ASV3331      3.465230e-04  3.614120e-04  3.768694e-04  3.929110e-04
## ASV7434     -3.464911e-04 -3.613773e-04 -3.768318e-04 -3.928701e-04
## ASV7720      5.933662e-05  6.270693e-05  6.628295e-05  7.007781e-05
## ASV8414     -3.464627e-04 -3.613465e-04 -3.767984e-04 -3.928340e-04
## ASV12139    -3.464308e-04 -3.613119e-04 -3.767608e-04 -3.927931e-04
## ASV1824      3.374832e-04  3.519557e-04  3.669783e-04  3.825658e-04
## ASV2094      3.420168e-04  3.567018e-04  3.719466e-04  3.877666e-04
## ASV2770     -8.182199e-05 -8.601553e-05 -9.043210e-05 -9.508383e-05
## ASV3505     -1.647452e-04 -1.712636e-04 -1.779778e-04 -1.848880e-04
## ASV1935      3.463283e-04  3.612006e-04  3.766400e-04  3.926621e-04
## ASV5764     -3.462965e-04 -3.611660e-04 -3.766024e-04 -3.926213e-04
## ASV6806      2.251900e-04  2.358009e-04  2.469046e-04  2.585232e-04
## ASV6942     -3.462670e-04 -3.611339e-04 -3.765676e-04 -3.925835e-04
## ASV1166      3.810546e-04  3.975271e-04  4.146380e-04  4.324057e-04
## ASV1664      2.720260e-04  2.840457e-04  2.965534e-04  3.095650e-04
## ASV2568      3.462055e-04  3.610671e-04  3.764949e-04  3.925046e-04
## ASV3525      3.461737e-04  3.610325e-04  3.764574e-04  3.924637e-04
## ASV4965     -4.165904e-04 -4.350024e-04 -4.541644e-04 -4.741015e-04
## ASV6607     -2.122708e-04 -2.209491e-04 -2.299172e-04 -2.391789e-04
## ASV7187      1.183229e-04  1.236221e-04  1.291423e-04  1.348911e-04
## ASV0388     -3.493029e-04 -3.658086e-04 -3.830866e-04 -4.011724e-04
## ASV1420      2.868685e-06  3.130016e-06  3.414280e-06  3.723369e-06
## ASV14293     1.140344e-04  1.195635e-04  1.253637e-04  1.314483e-04
## ASV17785     2.857392e-06  3.117583e-06  3.400592e-06  3.708299e-06
## ASV7678      1.916924e-05  1.944083e-05  1.967072e-05  1.985269e-05
## ASV2253      9.615901e-05  1.008068e-04  1.056809e-04  1.107923e-04
## ASV4150      1.894174e-04  1.977023e-04  2.063173e-04  2.152729e-04
## ASV3836     -4.410321e-04 -4.610984e-04 -4.820352e-04 -5.038765e-04
## ASV16231    -3.633929e-04 -3.803257e-04 -3.980302e-04 -4.165398e-04
## ASV2730      7.326097e-06  7.667626e-06  8.025137e-06  8.399420e-06
## ASV2072      2.031090e-04  2.117708e-04  2.207574e-04  2.300770e-04
## ASV2160      5.634187e-05  5.925169e-05  6.231993e-05  6.555576e-05
## ASV5013      6.582447e-05  6.848832e-05  7.123645e-05  7.406919e-05
## ASV2586      1.201683e-04  1.255608e-04  1.311791e-04  1.370314e-04
## ASV1442      9.469305e-05  9.904665e-05  1.035908e-04  1.083328e-04
## ASV3101      1.322231e-04  1.376423e-04  1.432418e-04  1.490236e-04
## ASV3323     -1.130861e-04 -1.184011e-04 -1.239552e-04 -1.297576e-04
## ASV1812      3.412882e-04  3.559215e-04  3.711108e-04  3.868712e-04
## ASV6120     -4.171602e-05 -4.385685e-05 -4.611242e-05 -4.848915e-05
## ASV2565      7.441172e-05  7.758600e-05  8.087921e-05  8.429438e-05
## ASV6687      3.848002e-05  4.018298e-05  4.195534e-05  4.379937e-05
## ASV5357     -3.021306e-04 -3.159180e-04 -3.303062e-04 -3.453188e-04
## ASV9383      1.490901e-04  1.556133e-04  1.623963e-04  1.694474e-04
## ASV11753    -2.584787e-04 -2.702471e-04 -2.825260e-04 -2.953354e-04
## ASV11512    -7.166379e-05 -7.492358e-05 -7.832481e-05 -8.187301e-05
## ASV2791     -1.196175e-05 -1.266824e-05 -1.342012e-05 -1.422046e-05
## ASV0664     -5.460098e-04 -5.707035e-04 -5.964530e-04 -6.232980e-04
## ASV3436      5.803669e-05  6.110106e-05  6.433853e-05  6.775971e-05
## ASV5755      3.714283e-04  3.881282e-04  4.055331e-04  4.236685e-04
## ASV10970    -3.660001e-04 -3.826488e-04 -4.000180e-04 -4.181355e-04
## ASV11798    -1.867097e-04 -1.951940e-04 -2.040449e-04 -2.132762e-04
## ASV18193    -3.659487e-04 -3.825926e-04 -3.999566e-04 -4.180684e-04
## ASV2548      3.836668e-04  4.007848e-04  4.186154e-04  4.371837e-04
## ASV3901      4.147025e-04  4.332082e-04  4.524845e-04  4.725587e-04
## ASV5197      5.362489e-06  5.099137e-06  4.781095e-06  4.402760e-06
## ASV5859      1.841660e-04  1.924068e-04  2.009933e-04  2.099380e-04
## ASV6240     -3.659280e-04 -3.825699e-04 -3.999317e-04 -4.180412e-04
## ASV7281      3.658923e-04  3.825309e-04  3.998891e-04  4.179946e-04
## ASV7635      2.060411e-04  2.155341e-04  2.254488e-04  2.358025e-04
## ASV8822     -3.658637e-04 -3.824996e-04 -3.998549e-04 -4.179572e-04
## ASV4810     -7.664323e-05 -7.984074e-05 -8.314917e-05 -8.657018e-05
## ASV5308      3.829381e-04  4.003796e-04  4.185785e-04  4.375644e-04
## ASV2749     -4.198972e-04 -4.391719e-04 -4.592974e-04 -4.803079e-04
## ASV0298      3.418967e-05  3.629986e-05  3.855226e-05  4.095696e-05
## ASV2597     -3.939467e-04 -4.120942e-04 -4.310486e-04 -4.508430e-04
## ASV5758     -1.638449e-04 -1.713362e-04 -1.791561e-04 -1.873177e-04
## ASV9987     -4.158994e-04 -4.349383e-04 -4.548130e-04 -4.755568e-04
## ASV0971      8.214034e-05  8.540496e-05  8.877274e-05  9.224483e-05
## ASV0627     -4.065832e-04 -4.253532e-04 -4.449616e-04 -4.654432e-04
## ASV1758      3.674737e-04  3.842013e-04  4.016548e-04  4.198627e-04
## ASV4559      1.835260e-06  1.985346e-06  2.147296e-06  2.321947e-06
## ASV11400    -1.451197e-05 -1.497959e-05 -1.544907e-05 -1.591868e-05
## ASV11559    -3.703088e-04 -3.873686e-04 -4.051874e-04 -4.237967e-04
## ASV3943     -3.702723e-04 -3.873286e-04 -4.051436e-04 -4.237488e-04
## ASV10389     6.825957e-05  7.114294e-05  7.413032e-05  7.722376e-05
## ASV5168      3.249936e-04  3.393453e-04  3.542798e-04  3.698163e-04
## ASV5724      2.286425e-04  2.391952e-04  2.502186e-04  2.617319e-04
## ASV6337      7.034343e-05  7.318053e-05  7.610723e-05  7.912399e-05
## ASV11063     2.047056e-04  2.135261e-04  2.226853e-04  2.321927e-04
## ASV4279     -3.942968e-05 -4.122685e-05 -4.310205e-05 -4.505831e-05
## ASV7660     -1.538766e-04 -1.610804e-04 -1.686152e-04 -1.764959e-04
## ASV8218     -1.538612e-04 -1.610635e-04 -1.685967e-04 -1.764756e-04
## ASV3574      6.028867e-04  6.309349e-04  6.602563e-04  6.909055e-04
## ASV12050    -1.538641e-04 -1.610666e-04 -1.686001e-04 -1.764793e-04
## ASV3897      1.359667e-04  1.419356e-04  1.481439e-04  1.545995e-04
## ASV3856     -4.616516e-04 -4.826961e-04 -5.046548e-04 -5.275632e-04
## ASV3024     -1.475135e-04 -1.546422e-04 -1.621157e-04 -1.699504e-04
## ASV8715     -3.592058e-04 -3.756077e-04 -3.927260e-04 -4.105888e-04
## ASV6917     -1.499041e-04 -1.562152e-04 -1.627553e-04 -1.695299e-04
## ASV1132      3.732736e-04  3.906881e-04  4.088980e-04  4.279381e-04
## ASV3583      1.881301e-04  1.970065e-04  2.062976e-04  2.160223e-04
## ASV0328      5.936835e-04  6.208956e-04  6.493066e-04  6.789650e-04
## ASV0915     -1.998618e-04 -2.092309e-04 -2.190322e-04 -2.292852e-04
## ASV2677      2.026183e-04  2.122273e-04  2.222886e-04  2.328229e-04
## ASV0599      2.025014e-04  2.115258e-04  2.209263e-04  2.307166e-04
## ASV0283     -5.405867e-04 -5.651786e-04 -5.908364e-04 -6.176017e-04
## ASV1028      2.249815e-04  2.355137e-04  2.465296e-04  2.580506e-04
## ASV0523      4.088525e-04  4.277622e-04  4.475194e-04  4.681594e-04
## ASV8201     -2.492721e-04 -2.608324e-04 -2.729127e-04 -2.855349e-04
## ASV2795     -7.785153e-05 -8.136728e-05 -8.503318e-05 -8.885490e-05
## ASV3563     -7.772688e-05 -8.123666e-05 -8.489631e-05 -8.871147e-05
## ASV1553     -1.404353e-04 -1.464374e-04 -1.526660e-04 -1.591271e-04
## ASV7155     -4.169495e-05 -4.410438e-05 -4.666033e-05 -4.937168e-05
## ASV0365      5.209339e-04  5.444591e-04  5.689894e-04  5.945629e-04
## ASV8583     -3.581666e-04 -3.743499e-04 -3.912240e-04 -4.088149e-04
## ASV5400      1.931284e-05  2.025435e-05  2.124125e-05  2.227555e-05
## ASV5908      2.756075e-04  2.876976e-04  3.002705e-04  3.133411e-04
## ASV2075      1.575511e-04  1.648573e-04  1.724924e-04  1.804701e-04
## ASV2520     -3.143471e-04 -3.289480e-04 -3.442094e-04 -3.601599e-04
## ASV9596     -1.528127e-04 -1.594572e-04 -1.663623e-04 -1.735357e-04
## ASV1131     -5.007862e-05 -5.200649e-05 -5.398845e-05 -5.602429e-05
## ASV0579     -1.017355e-04 -1.063264e-04 -1.111135e-04 -1.161041e-04
## ASV0288     -4.973931e-04 -5.197492e-04 -5.430502e-04 -5.673308e-04
## ASV4053      8.019513e-05  8.333017e-05  8.655600e-05  8.987233e-05
## ASV1736     -2.662313e-04 -2.783489e-04 -2.909917e-04 -3.041799e-04
## ASV1254      2.725549e-04  2.845616e-04  2.970541e-04  3.100485e-04
## ASV9038     -4.364611e-04 -4.565188e-04 -4.774628e-04 -4.993289e-04
## ASV4746      3.992651e-04  4.178874e-04  4.373600e-04  4.577201e-04
## ASV5803      1.509845e-04  1.579187e-04  1.651595e-04  1.727194e-04
## ASV0525      1.751176e-05  1.836153e-05  1.925302e-05  2.018828e-05
## ASV1974      2.280235e-04  2.379664e-04  2.483006e-04  2.590377e-04
## ASV1827      3.832936e-04  4.003179e-04  4.180428e-04  4.364923e-04
## ASV30780     1.821973e-05  1.887675e-05  1.954604e-05  2.022657e-05
## ASV9342      1.501305e-05  1.589854e-05  1.684149e-05  1.784595e-05
## ASV21626    -3.636571e-04 -3.801231e-04 -3.972946e-04 -4.151982e-04
## ASV1232     -2.568028e-04 -2.683161e-04 -2.803130e-04 -2.928110e-04
## ASV5578     -2.604211e-04 -2.723705e-04 -2.848470e-04 -2.978718e-04
## ASV5868      2.712950e-04  2.831855e-04  2.955522e-04  3.084104e-04
## ASV13625    -1.127250e-04 -1.177555e-04 -1.229946e-04 -1.284495e-04
## ASV3614      4.109399e-05  4.273899e-05  4.443534e-05  4.618330e-05
## ASV2128      2.357264e-04  2.466520e-04  2.580690e-04  2.699983e-04
## ASV5086      5.106894e-05  5.331414e-05  5.564905e-05  5.807644e-05
## ASV6614     -2.604068e-04 -2.723548e-04 -2.848298e-04 -2.978529e-04
## ASV9451     -2.603812e-04 -2.723268e-04 -2.847991e-04 -2.978194e-04
## ASV9533     -2.603555e-04 -2.722988e-04 -2.847685e-04 -2.977859e-04
## ASV10697     3.966554e-06  4.334292e-06  4.735231e-06  5.172244e-06
## ASV1473     -1.207687e-04 -1.259692e-04 -1.313685e-04 -1.369720e-04
## ASV1414     -7.753455e-05 -8.116569e-05 -8.496193e-05 -8.893016e-05
## ASV1567     -7.698320e-05 -8.084480e-05 -8.490750e-05 -8.918230e-05
## ASV6395     -2.630338e-04 -2.752322e-04 -2.879810e-04 -3.013036e-04
## ASV2366      1.035416e-04  1.077676e-04  1.121323e-04  1.166371e-04
## ASV2537      1.036678e-04  1.080013e-04  1.124884e-04  1.171322e-04
## ASV5378     -2.630208e-04 -2.752177e-04 -2.879650e-04 -3.012859e-04
## ASV5929     -2.767677e-04 -2.895889e-04 -3.029874e-04 -3.169874e-04
## ASV6360      2.178532e-04  2.274718e-04  2.374797e-04  2.478891e-04
## ASV7916     -4.540893e-05 -4.772909e-05 -5.017420e-05 -5.275148e-05
## ASV13322     8.793088e-05  9.216736e-05  9.660926e-05  1.012666e-04
## ASV6207     -3.318550e-04 -3.469960e-04 -3.627966e-04 -3.792828e-04
## ASV8823     -2.644342e-04 -2.765805e-04 -2.892634e-04 -3.025047e-04
## ASV1379      3.677383e-04  3.845513e-04  4.021000e-04  4.204136e-04
## ASV3259     -3.677023e-04 -3.845119e-04 -4.020569e-04 -4.203665e-04
## ASV18748     1.737997e-06  2.005727e-06  2.302977e-06  2.632610e-06
## ASV3570      8.011996e-05  8.383016e-05  8.770698e-05  9.175741e-05
## ASV0790     -7.632487e-05 -7.897815e-05 -8.167496e-05 -8.441102e-05
## ASV5149     -3.354564e-04 -3.506372e-04 -3.664678e-04 -3.829726e-04
## ASV1730     -3.465074e-04 -3.622637e-04 -3.787014e-04 -3.958469e-04
## ASV3488     -2.802737e-05 -2.919918e-05 -3.041272e-05 -3.166885e-05
## ASV5486     -3.777626e-04 -3.955284e-04 -4.141193e-04 -4.335725e-04
## ASV1319      5.614022e-05  5.785514e-05  5.957104e-05  6.128182e-05
## ASV15328    -2.584118e-04 -2.701773e-04 -2.824535e-04 -2.952604e-04
## ASV5994      3.733398e-04  3.903926e-04  4.081903e-04  4.267621e-04
## ASV4992     -2.958072e-05 -3.082808e-05 -3.212041e-05 -3.345863e-05
## ASV1788     -4.053406e-04 -4.231204e-04 -4.416126e-04 -4.608398e-04
## ASV3264     -3.763820e-06 -3.672628e-06 -3.553189e-06 -3.402162e-06
## ASV4895      1.711959e-05  1.778171e-05  1.846173e-05  1.915935e-05
## ASV9218     -5.529190e-06 -5.503550e-06 -5.451237e-06 -5.368869e-06
## ASV0736     -8.816889e-06 -9.477459e-06 -1.019050e-05 -1.096024e-05
## ASV0916      2.583514e-04  2.701115e-04  2.823819e-04  2.951824e-04
## ASV15761    -2.583262e-04 -2.700839e-04 -2.823517e-04 -2.951495e-04
## ASV4191      3.207945e-04  3.350708e-04  3.499368e-04  3.654130e-04
## ASV3268     -6.525393e-05 -6.800403e-05 -7.085286e-05 -7.380236e-05
## ASV15321    -4.295147e-05 -4.514903e-05 -4.746454e-05 -4.990468e-05
## ASV0708     -2.590240e-04 -2.710754e-04 -2.836740e-04 -2.968434e-04
## ASV4100      2.971760e-05  3.086334e-05  3.203991e-05  3.324681e-05
## ASV1627      2.049288e-04  2.135431e-04  2.224709e-04  2.317194e-04
## ASV7045     -2.288281e-04 -2.393157e-04 -2.502637e-04 -2.616905e-04
## ASV3271      5.248719e-05  5.422892e-05  5.599325e-05  5.777708e-05
## ASV6200     -4.015904e-05 -4.209439e-05 -4.412440e-05 -4.625385e-05
## ASV2727     -2.717148e-04 -2.846114e-04 -2.981144e-04 -3.122514e-04
## ASV3523     -3.570274e-04 -3.731959e-04 -3.900576e-04 -4.076385e-04
## ASV2259      2.412335e-04  2.522392e-04  2.637250e-04  2.757097e-04
## ASV0181      3.536988e-04  3.696074e-04  3.861888e-04  4.034677e-04
## ASV1680      7.096790e-04  7.419226e-04  7.755589e-04  8.106416e-04
## ASV0176      7.149503e-05  7.454075e-05  7.769893e-05  8.097207e-05
## ASV10458    -2.595685e-04 -2.714404e-04 -2.838325e-04 -2.967656e-04
## ASV10658    -2.595431e-04 -2.714125e-04 -2.838020e-04 -2.967323e-04
## ASV16807    -2.595176e-04 -2.713847e-04 -2.837716e-04 -2.966991e-04
## ASV2113     -2.594922e-04 -2.713569e-04 -2.837412e-04 -2.966658e-04
## ASV2403      2.654362e-04  2.773730e-04  2.898140e-04  3.027774e-04
## ASV2484     -2.594816e-04 -2.713452e-04 -2.837284e-04 -2.966518e-04
## ASV8876     -2.594561e-04 -2.713174e-04 -2.836980e-04 -2.966186e-04
## ASV0386      3.805451e-04  3.982275e-04  4.167104e-04  4.360283e-04
## ASV0351      1.040184e-04  1.085765e-04  1.133156e-04  1.182413e-04
## ASV4942     -1.476889e-04 -1.543962e-04 -1.613937e-04 -1.686929e-04
## ASV5128     -1.148598e-04 -1.201934e-04 -1.257676e-04 -1.315925e-04
## ASV3496      1.299762e-04  1.363173e-04  1.429731e-04  1.499598e-04
## ASV3329      3.786147e-04  3.961494e-04  4.144722e-04  4.336164e-04
## ASV7878     -2.583872e-04 -2.701450e-04 -2.824121e-04 -2.952083e-04
## ASV8251     -9.814334e-05 -1.026046e-04 -1.072584e-04 -1.121119e-04
## ASV15958    -8.507051e-05 -8.900960e-05 -9.312539e-05 -9.742527e-05
## ASV7972     -3.700818e-04 -3.871142e-04 -4.049023e-04 -4.234772e-04
## ASV2088      3.700453e-04  3.870742e-04  4.048586e-04  4.234294e-04
## ASV3054     -1.741925e-04 -1.822112e-04 -1.905854e-04 -1.993296e-04
## ASV4494     -3.699942e-04 -3.870183e-04 -4.047975e-04 -4.233625e-04
## ASV0087     -6.998044e-04 -7.315834e-04 -7.647336e-04 -7.993077e-04
## ASV1614     -2.860171e-04 -2.989795e-04 -3.124983e-04 -3.265947e-04
## ASV3037     -1.586314e-04 -1.658731e-04 -1.734308e-04 -1.813170e-04
## ASV6615     -4.241608e-05 -4.458668e-05 -4.687327e-05 -4.928232e-05
## ASV1027      1.070881e-04  1.118650e-04  1.168397e-04  1.220191e-04
## ASV2754     -6.802665e-05 -7.139566e-05 -7.493572e-05 -7.865574e-05
## ASV0536     -5.290435e-05 -5.546267e-05 -5.814568e-05 -6.095948e-05
## ASV2318     -1.115488e-04 -1.167984e-04 -1.222921e-04 -1.280408e-04
## ASV5954      2.187387e-04  2.282565e-04  2.381483e-04  2.484254e-04
## ASV9028      1.553311e-04  1.624603e-04  1.699038e-04  1.776743e-04
## ASV6600     -2.631580e-04 -2.753650e-04 -2.881229e-04 -3.014550e-04
## ASV1923     -6.876866e-05 -7.180982e-05 -7.497413e-05 -7.826550e-05
## ASV4034     -5.206179e-05 -5.480540e-05 -5.770234e-05 -6.076172e-05
## ASV9933     -2.631214e-04 -2.753250e-04 -2.880790e-04 -3.014070e-04
## ASV1575      4.853680e-05  5.057231e-05  5.268166e-05  5.486663e-05
## ASV7812     -4.459233e-04 -4.662279e-04 -4.874133e-04 -5.095136e-04
## ASV0515      2.858137e-04  2.984663e-04  3.116350e-04  3.253370e-04
## ASV1149     -3.430869e-05 -3.636279e-05 -3.854977e-05 -4.087860e-05
## ASV3791      1.206720e-04  1.263726e-04  1.323399e-04  1.385861e-04
## ASV4065     -4.172224e-04 -4.362622e-04 -4.561311e-04 -4.768618e-04
## ASV10631    -2.444915e-05 -2.580030e-05 -2.723260e-05 -2.875133e-05
## ASV2359     -4.094052e-04 -4.272414e-04 -4.457816e-04 -4.650476e-04
## ASV3206     -2.598166e-04 -2.717153e-04 -2.841373e-04 -2.971036e-04
## ASV4415      2.114809e-04  2.211611e-04  2.312655e-04  2.418109e-04
## ASV4467     -1.858257e-04 -1.942217e-04 -2.029763e-04 -2.121030e-04
## ASV5598      3.201220e-04  3.352206e-04  3.510241e-04  3.675647e-04
## ASV5910     -2.867379e-04 -2.998970e-04 -3.136373e-04 -3.279823e-04
## ASV9494     -2.597471e-04 -2.716393e-04 -2.840542e-04 -2.970127e-04
## ASV6548     -2.119692e-04 -2.216304e-04 -2.317121e-04 -2.422311e-04
## ASV8669     -2.597012e-04 -2.715891e-04 -2.839993e-04 -2.969527e-04
## ASV0674      1.601929e-04  1.671692e-04  1.744188e-04  1.819496e-04
## ASV0061     -8.100645e-05 -8.559345e-05 -9.045845e-05 -9.561897e-05
## ASV0310     -1.597146e-04 -1.667637e-04 -1.741032e-04 -1.817436e-04
## ASV0582      4.846855e-05  5.038734e-05  5.236419e-05  5.439920e-05
## ASV0739      4.931443e-04  5.160078e-04  5.399005e-04  5.648657e-04
## ASV1557      2.067165e-04  2.165192e-04  2.267836e-04  2.375312e-04
## ASV0146      4.563059e-04  4.763000e-04  4.970923e-04  5.187078e-04
## ASV3832      4.673766e-04  4.882441e-04  5.099791e-04  5.326119e-04
## ASV0734      1.053377e-04  1.102595e-04  1.154053e-04  1.207848e-04
## ASV3036     -3.447524e-04 -3.607645e-04 -3.775013e-04 -3.949940e-04
## ASV0240      9.204842e-05  9.615168e-05  1.004250e-04  1.048741e-04
## ASV2513     -5.148040e-04 -5.379866e-04 -5.621521e-04 -5.873366e-04
## ASV1118     -1.383217e-04 -1.448885e-04 -1.517636e-04 -1.589609e-04
## ASV7286     -2.588905e-04 -2.706987e-04 -2.830213e-04 -2.958785e-04
## ASV1077      3.447110e-04  3.601217e-04  3.761761e-04  3.928969e-04
## ASV1255     -2.588362e-04 -2.706394e-04 -2.829566e-04 -2.958079e-04
## ASV1794     -1.585729e-05 -1.662636e-05 -1.743293e-05 -1.827882e-05
## ASV2439     -2.588120e-04 -2.706130e-04 -2.829277e-04 -2.957763e-04
## ASV2467     -2.587867e-04 -2.705853e-04 -2.828974e-04 -2.957432e-04
## ASV3346     -2.587614e-04 -2.705577e-04 -2.828672e-04 -2.957102e-04
## ASV3973     -2.587361e-04 -2.705300e-04 -2.828370e-04 -2.956772e-04
## ASV4521      1.138641e-04  1.189259e-04  1.241953e-04  1.296791e-04
## ASV1909     -3.089920e-04 -3.234656e-04 -3.386051e-04 -3.544399e-04
## ASV3855     -2.315396e-04 -2.419895e-04 -2.528842e-04 -2.642403e-04
## ASV0810      3.098697e-04  3.241050e-04  3.389696e-04  3.544887e-04
## ASV1765      3.701177e-04  3.872892e-04  4.052358e-04  4.239905e-04
## ASV0763      2.005779e-04  2.097039e-04  2.192253e-04  2.291576e-04
## ASV0302     -2.181526e-04 -2.279196e-04 -2.380950e-04 -2.486935e-04
## ASV2643     -2.958627e-04 -3.087721e-04 -3.221948e-04 -3.361473e-04
## ASV0440      1.161358e-04  1.215781e-04  1.272692e-04  1.332198e-04
## ASV4899     -2.083163e-04 -2.174221e-04 -2.268882e-04 -2.367253e-04
## ASV0287     -1.277662e-04 -1.336896e-04 -1.398808e-04 -1.463513e-04
## ASV3220      1.600306e-04  1.674876e-04  1.752828e-04  1.834305e-04
## ASV1007     -9.093122e-05 -9.486246e-05 -9.894497e-05 -1.031829e-04
## ASV2929     -5.757614e-05 -5.994233e-05 -6.238815e-05 -6.491464e-05
## ASV1496     -2.206416e-04 -2.309657e-04 -2.417638e-04 -2.530568e-04
## ASV4975      9.619271e-05  1.006259e-04  1.052555e-04  1.100892e-04
## ASV4392     -1.228506e-05 -1.256162e-05 -1.282321e-05 -1.306668e-05
## ASV4653     -2.622475e-04 -2.743698e-04 -2.870352e-04 -3.002666e-04
## ASV0230     -1.345726e-04 -1.408782e-04 -1.474738e-04 -1.543720e-04
## ASV0840      1.891271e-04  1.978497e-04  2.069614e-04  2.164785e-04
## ASV4132     -5.691821e-05 -5.965912e-05 -6.253281e-05 -6.554571e-05
## ASV3344      1.959009e-04  2.046119e-04  2.136821e-04  2.231240e-04
## ASV12096    -2.661294e-04 -2.784730e-04 -2.913719e-04 -3.048492e-04
## ASV1550      8.703802e-05  9.059900e-05  9.427872e-05  9.807867e-05
## ASV3542     -3.951888e-04 -4.136776e-04 -4.330117e-04 -4.532273e-04
## ASV8795     -1.527733e-04 -1.598688e-04 -1.672848e-04 -1.750350e-04
## ASV2532     -8.545113e-06 -9.026684e-06 -9.537662e-06 -1.007997e-05
## ASV3087      6.256004e-05  6.527749e-05  6.810103e-05  7.103375e-05
## ASV9476     -1.527625e-04 -1.598569e-04 -1.672717e-04 -1.750206e-04
## ASV13721    -1.527472e-04 -1.598402e-04 -1.672535e-04 -1.750006e-04
## ASV3842      2.496545e-04  2.607182e-04  2.722343e-04  2.842182e-04
## ASV1663      4.494363e-04  4.693741e-04  4.901298e-04  5.117311e-04
## ASV0432      1.056163e-04  1.102920e-04  1.151586e-04  1.202223e-04
## ASV4356      4.465398e-04  4.668611e-04  4.880634e-04  5.101811e-04
## ASV4524      1.095024e-04  1.147296e-04  1.202060e-04  1.259433e-04
## ASV0169     -2.215437e-04 -2.319250e-04 -2.427836e-04 -2.541405e-04
## ASV0368     -1.903881e-04 -1.992989e-04 -2.086182e-04 -2.183640e-04
## ASV2603      8.092536e-08  8.081551e-08  7.962100e-08  7.709809e-08
## ASV3777      2.502708e-04  2.617471e-04  2.737287e-04  2.862357e-04
## ASV3978      2.167177e-04  2.264955e-04  2.366886e-04  2.473122e-04
## ASV0413     -1.796279e-04 -1.880279e-04 -1.968123e-04 -2.059979e-04
## ASV0997     -3.957536e-08 -3.558674e-08 -3.015765e-08 -2.301290e-08
## ASV1195     -3.958160e-08 -3.559610e-08 -3.017100e-08 -2.303130e-08
## ASV2522     -1.176749e-04 -1.230366e-04 -1.286314e-04 -1.344683e-04
## ASV4733      2.152645e-04  2.251649e-04  2.355035e-04  2.462979e-04
## ASV1063      3.790450e-04  3.969244e-04  4.156383e-04  4.352247e-04
## ASV0612     -4.822489e-04 -5.047054e-04 -5.281843e-04 -5.527300e-04
## ASV1903     -3.789618e-04 -3.968332e-04 -4.155384e-04 -4.351152e-04
## ASV3576     -1.114140e-04 -1.169466e-04 -1.227625e-04 -1.288766e-04
## ASV4285     -2.695634e-04 -2.821323e-04 -2.952734e-04 -3.090111e-04
## ASV3406     -1.399247e-04 -1.463773e-04 -1.531177e-04 -1.601579e-04
## ASV2379     -2.571257e-04 -2.681941e-04 -2.796877e-04 -2.916184e-04
## ASV0528      3.286281e-04  3.437785e-04  3.596029e-04  3.761289e-04
## ASV6190     -4.312793e-05 -4.523315e-05 -4.744262e-05 -4.976156e-05
## ASV1537     -2.877462e-06 -2.860944e-06 -2.829398e-06 -2.780830e-06
## ASV16780    -2.916215e-04 -3.048795e-04 -3.187114e-04 -3.331394e-04
## ASV0477      7.250907e-04  7.583057e-04  7.929808e-04  8.291745e-04
## ASV1499      1.681712e-04  1.764525e-04  1.851492e-04  1.942824e-04
## ASV14736     1.255483e-04  1.312249e-04  1.371448e-04  1.433172e-04
## ASV0179     -1.048338e-04 -1.097027e-04 -1.147917e-04 -1.201101e-04
## ASV3153      1.020440e-05  1.104824e-05  1.196429e-05  1.295870e-05
## ASV0266      3.394128e-04  3.551162e-04  3.715253e-04  3.886700e-04
## ASV0761      5.006239e-04  5.232585e-04  5.468621e-04  5.714712e-04
## ASV0269     -5.050925e-05 -5.316395e-05 -5.596752e-05 -5.892899e-05
## ASV7259     -9.653645e-05 -1.013559e-04 -1.064217e-04 -1.117466e-04
## ASV2067     -1.055796e-04 -1.102220e-04 -1.150511e-04 -1.200730e-04
## ASV2985     -2.976327e-04 -3.112698e-04 -3.255043e-04 -3.403596e-04
## ASV0975     -4.518953e-04 -4.727921e-04 -4.946253e-04 -5.174342e-04
## ASV2240      2.669534e-04  2.787967e-04  2.911270e-04  3.039611e-04
## ASV2297      8.577590e-05  8.930181e-05  9.294742e-05  9.671457e-05
## ASV2657      1.120004e-04  1.168872e-04  1.219679e-04  1.272487e-04
## ASV3784      4.835676e-06  5.279361e-06  5.762400e-06  6.288096e-06
## ASV4333      4.834763e-06  5.278319e-06  5.761212e-06  6.286741e-06
## ASV5547      2.292702e-04  2.391271e-04  2.493620e-04  2.599855e-04
## ASV5813      9.315907e-05  9.719392e-05  1.013854e-04  1.057381e-04
## ASV8049      1.122942e-04  1.173281e-04  1.225738e-04  1.280392e-04
## ASV8661     -4.848262e-06 -5.293000e-06 -5.777172e-06 -6.304086e-06
## ASV9510      1.310927e-04  1.369337e-04  1.430166e-04  1.493498e-04
## ASV1401      6.869954e-05  7.172989e-05  7.488334e-05  7.816401e-05
## ASV1417     -1.355573e-04 -1.411034e-04 -1.468354e-04 -1.527560e-04
## ASV2169      4.800787e-04  5.019489e-04  5.247702e-04  5.485801e-04
## ASV5354     -4.865351e-06 -5.311672e-06 -5.797569e-06 -6.326362e-06
## ASV5379     -4.864433e-06 -5.310624e-06 -5.796374e-06 -6.324999e-06
## ASV6078     -4.863515e-06 -5.309577e-06 -5.795180e-06 -6.323638e-06
## ASV6417      2.926353e-04  3.057391e-04  3.193917e-04  3.336127e-04
## ASV8304      2.113639e-04  2.206325e-04  2.302720e-04  2.402941e-04
## ASV8766     -4.892661e-06 -5.341331e-06 -5.829764e-06 -6.361293e-06
## ASV10861     8.804018e-05  9.183770e-05  9.578084e-05  9.987357e-05
## ASV2057      4.748542e-04  4.965162e-04  5.191221e-04  5.427091e-04
## ASV4499      1.647067e-04  1.717244e-04  1.790036e-04  1.865507e-04
## ASV7415      5.278510e-05  5.522638e-05  5.777595e-05  6.043808e-05
## ASV2475     -2.038415e-04 -2.132085e-04 -2.229905e-04 -2.332044e-04
## ASV3517     -3.346083e-04 -3.502760e-04 -3.666646e-04 -3.838060e-04
## ASV1864      2.225635e-04  2.324794e-04  2.428055e-04  2.535560e-04
## ASV2756      2.578726e-04  2.695873e-04  2.818080e-04  2.945543e-04
## ASV0778      2.578475e-04  2.695598e-04  2.817780e-04  2.945216e-04
## ASV3201      6.031026e-05  6.344564e-05  6.675333e-05  7.024342e-05
## ASV3358      2.578264e-04  2.695368e-04  2.817529e-04  2.944942e-04
## ASV5681     -2.578013e-04 -2.695093e-04 -2.817229e-04 -2.944614e-04
## ASV7256      1.252930e-04  1.310915e-04  1.371526e-04  1.434878e-04
## ASV1704     -2.632062e-04 -2.750585e-04 -2.874122e-04 -3.002854e-04
## ASV4445      4.115766e-04  4.294562e-04  4.480369e-04  4.673399e-04
## ASV8649     -2.577502e-04 -2.694536e-04 -2.816621e-04 -2.943951e-04
## ASV0597      2.678628e-04  2.800164e-04  2.926936e-04  3.059146e-04
## ASV0861      3.404376e-04  3.557230e-04  3.716524e-04  3.882491e-04
## ASV2423      4.133261e-04  4.319676e-04  4.514008e-04  4.716550e-04
## ASV1548      1.997214e-04  2.082531e-04  2.171046e-04  2.262839e-04
## ASV2564      3.432388e-04  3.585195e-04  3.744305e-04  3.909933e-04
## ASV2999      5.706002e-04  5.959111e-04  6.222601e-04  6.496821e-04
## ASV4543     -2.077580e-04 -2.174805e-04 -2.276501e-04 -2.382866e-04
## ASV8452      1.953454e-04  2.038712e-04  2.127335e-04  2.219424e-04
## ASV17287    -4.239615e-05 -4.460209e-05 -4.692978e-05 -4.938644e-05
## ASV3503     -2.659713e-04 -2.784466e-04 -2.914979e-04 -3.051511e-04
## ASV4727     -4.684038e-05 -4.933564e-05 -5.197296e-05 -5.476100e-05
## ASV5995     -2.262096e-04 -2.367999e-04 -2.478775e-04 -2.594639e-04
## ASV1665     -7.242006e-05 -7.580441e-05 -7.934368e-05 -8.304466e-05
## ASV2690     -3.372567e-04 -3.527098e-04 -3.688429e-04 -3.856835e-04
## ASV2823     -2.714881e-05 -2.832125e-05 -2.953910e-05 -3.080370e-05
## ASV5241     -4.509341e-04 -4.715854e-04 -4.931430e-04 -5.156431e-04
## ASV5473     -1.303529e-04 -1.365330e-04 -1.430044e-04 -1.497805e-04
## ASV2785      5.906653e-05  6.192417e-05  6.492119e-05  6.806438e-05
## ASV6645     -1.901967e-04 -1.988165e-04 -2.078064e-04 -2.171803e-04
## ASV0562      7.587543e-05  7.904491e-05  8.232463e-05  8.571627e-05
## ASV1163      7.813550e-05  8.178240e-05  8.559529e-05  8.958124e-05
## ASV1825      1.462643e-04  1.527799e-04  1.595642e-04  1.666265e-04
## ASV3795      3.238064e-04  3.384520e-04  3.537251e-04  3.696497e-04
## ASV3869     -7.364623e-05 -7.724470e-05 -8.102251e-05 -8.498887e-05
## ASV4330      2.499393e-04  2.613226e-04  2.731999e-04  2.855906e-04
## ASV6754      9.499719e-05  9.931931e-05  1.038284e-04  1.085315e-04
## ASV4598     -3.093533e-06 -3.386439e-06 -3.706577e-06 -4.056405e-06
## ASV2100      1.908824e-04  1.992947e-04  2.080474e-04  2.171515e-04
## ASV3518      9.482390e-05  9.898566e-05  1.033131e-04  1.078112e-04
## ASV3823      3.943376e-04  4.120559e-04  4.305220e-04  4.497630e-04
## ASV7357      2.423939e-04  2.533779e-04  2.648339e-04  2.767798e-04
## ASV7403     -3.095090e-04 -3.234604e-04 -3.380043e-04 -3.531625e-04
## ASV2934     -1.282452e-05 -1.329102e-05 -1.376673e-05 -1.425096e-05
## ASV5277     -1.611021e-04 -1.683578e-04 -1.759206e-04 -1.838018e-04
## ASV0281     -4.750687e-04 -4.965809e-04 -5.190170e-04 -5.424122e-04
## ASV11181    -1.783215e-04 -1.868423e-04 -1.957717e-04 -2.051294e-04
## ASV0254     -5.951516e-05 -6.164157e-05 -6.380603e-05 -6.600497e-05
## ASV0201     -8.331043e-05 -8.740172e-05 -9.169894e-05 -9.621285e-05
## ASV3656     -2.060618e-04 -2.160124e-04 -2.264483e-04 -2.373936e-04
## ASV7994     -3.677930e-04 -3.846340e-04 -4.022150e-04 -4.205654e-04
## ASV3584     -1.170642e-04 -1.218202e-04 -1.267339e-04 -1.318074e-04
## ASV2157      3.763239e-04  3.930825e-04  4.105361e-04  4.287089e-04
## ASV2935     -4.869591e-05 -5.093505e-05 -5.327334e-05 -5.571482e-05
## ASV9024     -3.432517e-04 -3.586518e-04 -3.746994e-04 -3.914179e-04
## ASV7711      2.072180e-04  2.169769e-04  2.271900e-04  2.378776e-04
## ASV11330    -2.614025e-04 -2.734478e-04 -2.860294e-04 -2.991697e-04
## ASV1875      2.300037e-04  2.405176e-04  2.514929e-04  2.629484e-04
## ASV5861      1.732926e-04  1.814591e-04  1.900054e-04  1.989488e-04
## ASV11562     1.524131e-05  1.597573e-05  1.674537e-05  1.755187e-05
## ASV18559    -2.613941e-04 -2.734386e-04 -2.860194e-04 -2.991587e-04
## ASV4384      2.539290e-04  2.658644e-04  2.783528e-04  2.914189e-04
## ASV1302      5.118487e-04  5.343022e-04  5.576580e-04  5.819454e-04
## ASV4673     -3.438398e-04 -3.598098e-04 -3.765010e-04 -3.939439e-04
## ASV1956      5.629923e-05  5.857870e-05  6.093504e-05  6.336974e-05
## ASV3286      2.403225e-04  2.516285e-04  2.634587e-04  2.758366e-04
## ASV4866     -3.767292e-04 -3.943971e-04 -4.128810e-04 -4.322172e-04
## ASV3129     -1.845960e-04 -1.931822e-04 -2.021586e-04 -2.115421e-04
## ASV4104      4.229191e-04  4.422055e-04  4.623315e-04  4.833302e-04
## ASV8983      3.449534e-06  3.607582e-06  3.773195e-06  3.946821e-06
## ASV2201      1.604767e-04  1.674513e-04  1.746987e-04  1.822269e-04
## ASV3055      1.090440e-04  1.135742e-04  1.182630e-04  1.231134e-04
## ASV0534     -5.502268e-04 -5.750530e-04 -6.009349e-04 -6.279117e-04
## ASV1019      1.938814e-05  2.051603e-05  2.171566e-05  2.299194e-05
## ASV18482    -2.559047e-04 -2.674349e-04 -2.794543e-04 -2.919810e-04
## ASV2694      8.429048e-05  8.780032e-05  9.143361e-05  9.519268e-05
## ASV3412     -7.792997e-05 -8.123975e-05 -8.467088e-05 -8.822598e-05
## ASV4174     -2.558740e-04 -2.674014e-04 -2.794178e-04 -2.919411e-04
## ASV4281     -2.558492e-04 -2.673744e-04 -2.793883e-04 -2.919089e-04
## ASV4949      2.862277e-04  2.988902e-04  3.120695e-04  3.257828e-04
## ASV5881      1.347783e-04  1.408150e-04  1.471043e-04  1.536552e-04
## ASV6299     -1.129532e-04 -1.179016e-04 -1.230468e-04 -1.283948e-04
## ASV0676      2.933313e-04  3.064387e-04  3.200935e-04  3.343153e-04
## ASV1066     -1.998426e-04 -2.087021e-04 -2.179238e-04 -2.275195e-04
## ASV1300     -1.711906e-04 -1.788519e-04 -1.868331e-04 -1.951454e-04
## ASV6455      8.383905e-05  8.767528e-05  9.167989e-05  9.585964e-05
## ASV3455     -2.558420e-04 -2.673665e-04 -2.793797e-04 -2.918996e-04
## ASV6531     -2.558173e-04 -2.673395e-04 -2.793502e-04 -2.918674e-04
## ASV0490      5.102087e-04  5.328424e-04  5.564099e-04  5.809441e-04
## ASV2588      2.975259e-05  3.160472e-05  3.358223e-05  3.569402e-05
## ASV5364      1.609630e-04  1.681702e-04  1.756786e-04  1.834987e-04
## ASV0981     -3.590989e-04 -3.757601e-04 -3.931731e-04 -4.113699e-04
## ASV1563     -7.377148e-05 -7.720513e-05 -8.079530e-05 -8.454886e-05
## ASV0376     -3.445136e-04 -3.604895e-04 -3.771848e-04 -3.946299e-04
## ASV7308     -2.287623e-06 -2.509207e-06 -2.752125e-06 -3.018409e-06
## ASV4817      5.410291e-05  5.630925e-05  5.858767e-05  6.093880e-05
## ASV8716     -3.596143e-04 -3.749105e-04 -3.907794e-04 -4.072362e-04
## ASV1849      4.598239e-04  4.797354e-04  5.004198e-04  5.218994e-04
## ASV9423     -3.575489e-04 -3.736054e-04 -3.903394e-04 -4.077754e-04
## ASV7690      1.370854e-05  1.438478e-05  1.509447e-05  1.583919e-05
## ASV4901      1.983897e-04  2.075409e-04  2.170999e-04  2.270835e-04
## ASV1830     -6.529053e-05 -6.882267e-05 -7.255949e-05 -7.651361e-05
## ASV2316     -2.636308e-04 -2.748914e-04 -2.865805e-04 -2.987102e-04
## ASV0693      3.972760e-04  4.155134e-04  4.345555e-04  4.544350e-04
## ASV1243     -2.070343e-05 -2.133188e-05 -2.195919e-05 -2.258279e-05
## ASV3867      1.049777e-04  1.098942e-04  1.150365e-04  1.204144e-04
## ASV7932      2.251567e-04  2.354698e-04  2.462354e-04  2.574716e-04
## ASV12608     1.641138e-04  1.719725e-04  1.802084e-04  1.888397e-04
## ASV1661      2.353295e-04  2.459938e-04  2.571159e-04  2.687131e-04
## ASV3957      2.482694e-04  2.597355e-04  2.717151e-04  2.842297e-04
## ASV0830     -3.900718e-04 -4.077122e-04 -4.261079e-04 -4.452877e-04
## ASV2078      4.437601e-04  4.640199e-04  4.851657e-04  5.072329e-04
## ASV13932    -2.624099e-04 -2.745491e-04 -2.872332e-04 -3.004851e-04
## ASV5300     -2.623839e-04 -2.745206e-04 -2.872020e-04 -3.004510e-04
## ASV1014     -1.404515e-04 -1.467923e-04 -1.534027e-04 -1.602925e-04
## ASV13059    -8.263087e-05 -8.682107e-05 -9.123164e-05 -9.587455e-05
## ASV4340      5.285861e-05  5.517507e-05  5.758476e-05  6.009076e-05
## ASV5591     -4.349280e-04 -4.545707e-04 -4.750511e-04 -4.964005e-04
## ASV6040     -3.480175e-04 -3.638134e-04 -3.802897e-04 -3.974726e-04
## ASV3904     -1.449721e-04 -1.517740e-04 -1.588895e-04 -1.663324e-04
## ASV2267     -4.077931e-05 -4.265228e-05 -4.460742e-05 -4.664791e-05
## ASV0573     -3.237723e-04 -3.379859e-04 -3.527693e-04 -3.681404e-04
## ASV0851     -3.511302e-04 -3.670647e-04 -3.836849e-04 -4.010168e-04
## ASV7805      1.108277e-04  1.160915e-04  1.216042e-04  1.273774e-04
## ASV3379      4.679570e-04  4.887571e-04  5.104165e-04  5.329648e-04
## ASV0825      2.143076e-04  2.244547e-04  2.350773e-04  2.461970e-04
## ASV2461      2.453713e-04  2.563943e-04  2.678827e-04  2.798539e-04
## ASV2783      3.430811e-04  3.586433e-04  3.748755e-04  3.918033e-04
## ASV0925      3.830629e-04  4.001196e-04  4.178812e-04  4.363721e-04
## ASV7023     -3.673283e-04 -3.842746e-04 -4.019768e-04 -4.204660e-04
## ASV5319      6.698469e-05  7.012653e-05  7.341208e-05  7.684745e-05
## ASV3213      2.293665e-04  2.399684e-04  2.510443e-04  2.626137e-04
## ASV3748     -5.786239e-05 -6.075484e-05 -6.379738e-05 -6.699819e-05
## ASV5491     -8.443744e-05 -8.855049e-05 -9.286767e-05 -9.739939e-05
## ASV7931      1.443562e-04  1.509971e-04  1.579319e-04  1.651724e-04
## ASV12767    -2.638540e-04 -2.761291e-04 -2.889616e-04 -3.023756e-04
## ASV6389      2.657111e-04  2.780266e-04  2.908969e-04  3.043455e-04
## ASV14867    -2.638273e-04 -2.760998e-04 -2.889296e-04 -3.023406e-04
## ASV5105      1.541002e-04  1.613837e-04  1.690076e-04  1.769873e-04
## ASV15927    -2.627653e-04 -2.749351e-04 -2.876523e-04 -3.009399e-04
## ASV2004      8.985142e-05  9.391289e-05  9.814861e-05  1.025653e-04
## ASV5554     -7.267048e-06 -8.190430e-06 -9.207176e-06 -1.032560e-05
## ASV10929    -1.839152e-04 -1.924424e-04 -2.013545e-04 -2.106680e-04
## ASV12778    -9.061418e-05 -9.478232e-05 -9.913551e-05 -1.036814e-04
## ASV14006    -2.627067e-04 -2.748709e-04 -2.875819e-04 -3.008628e-04
## ASV1603      2.570519e-04  2.690100e-04  2.815109e-04  2.945783e-04
## ASV11948     1.310314e-04  1.367621e-04  1.427196e-04  1.489107e-04
## ASV12912    -2.641401e-04 -2.764399e-04 -2.892991e-04 -3.027420e-04
## ASV13147    -2.641137e-04 -2.764110e-04 -2.892675e-04 -3.027074e-04
## ASV14761    -2.640874e-04 -2.763821e-04 -2.892359e-04 -3.026727e-04
## ASV8521      2.093843e-04  2.185870e-04  2.281581e-04  2.381090e-04
## ASV8581     -2.640696e-04 -2.763627e-04 -2.892145e-04 -3.026493e-04
## ASV9875     -4.583821e-05 -4.816071e-05 -5.060625e-05 -5.318171e-05
## ASV9986      1.753467e-04  1.835952e-04  1.922261e-04  2.012563e-04
## ASV2376      3.051311e-04  3.190105e-04  3.334911e-04  3.485962e-04
## ASV17535    -2.640510e-04 -2.763422e-04 -2.891920e-04 -3.026246e-04
## ASV14330    -2.535700e-04 -2.648893e-04 -2.766795e-04 -2.889572e-04
## ASV1333     -5.227025e-04 -5.452881e-04 -5.687480e-04 -5.931073e-04
## ASV2498      1.271649e-04  1.333236e-04  1.397820e-04  1.465546e-04
## ASV6352     -1.030286e-04 -1.074864e-04 -1.121171e-04 -1.169255e-04
## ASV8601     -1.295665e-04 -1.353224e-04 -1.413153e-04 -1.475534e-04
## ASV9776     -9.603979e-05 -1.001265e-04 -1.043647e-04 -1.087580e-04
## ASV1916      2.248446e-04  2.348937e-04  2.453631e-04  2.562681e-04
## ASV1555      2.900861e-05  3.049099e-05  3.205269e-05  3.369819e-05
## ASV2499      3.562749e-04  3.727874e-04  3.900435e-04  4.080747e-04
## ASV0703      2.931490e-04  3.066234e-04  3.206949e-04  3.353879e-04
## ASV2047      3.881458e-04  4.058070e-04  4.242341e-04  4.434568e-04
## ASV5492     -2.650987e-04 -2.774930e-04 -2.904560e-04 -3.040129e-04
## ASV6549     -2.739016e-05 -2.876478e-05 -3.021150e-05 -3.173436e-05
## ASV7757     -9.516433e-05 -9.989045e-05 -1.048587e-04 -1.100822e-04
## ASV0173     -2.678260e-06 -2.928170e-06 -3.200859e-06 -3.498325e-06
## ASV1248     -7.929750e-05 -8.274428e-05 -8.632514e-05 -9.004384e-05
## ASV6502      2.684789e-06  2.935251e-06  3.208533e-06  3.506637e-06
## ASV9844      2.684275e-06  2.934663e-06  3.207861e-06  3.505869e-06
## ASV3903      1.690097e-04  1.769396e-04  1.852356e-04  1.939140e-04
## ASV8199      2.670637e-06  2.919692e-06  3.191425e-06  3.487826e-06
## ASV3309     -1.162294e-05 -1.209478e-05 -1.258135e-05 -1.308262e-05
## ASV5826     -3.928115e-05 -4.122380e-05 -4.326463e-05 -4.540868e-05
## ASV1480     -3.546996e-04 -3.712904e-04 -3.886426e-04 -4.067899e-04
## ASV3090      7.487091e-05  7.823358e-05  8.173795e-05  8.538913e-05
## ASV0758     -2.126528e-04 -2.218433e-04 -2.313896e-04 -2.413020e-04
## ASV0811     -6.419565e-05 -6.698685e-05 -6.988755e-05 -7.290102e-05
## ASV2653      1.761613e-04  1.845057e-04  1.932418e-04  2.023875e-04
## ASV0978      1.822125e-04  1.908626e-04  1.999189e-04  2.093998e-04
## ASV6640     -3.665192e-04 -3.832804e-04 -4.007761e-04 -4.190356e-04
## ASV3423     -1.761126e-05 -1.865922e-05 -1.977648e-05 -2.096808e-05
## ASV0617      3.635687e-04  3.792457e-04  3.955301e-04  4.124398e-04
## ASV14947    -3.709547e-04 -3.880624e-04 -4.059317e-04 -4.245942e-04
## ASV18367    -2.046290e-04 -2.144409e-04 -2.247226e-04 -2.354961e-04
## ASV4574      2.811168e-04  2.933049e-04  3.059665e-04  3.191150e-04
## ASV10514    -1.984319e-04 -2.076984e-04 -2.173880e-04 -2.275191e-04
## ASV11779    -1.012085e-04 -1.064858e-04 -1.120512e-04 -1.179209e-04
## ASV7528     -3.213160e-04 -3.363241e-04 -3.520168e-04 -3.684237e-04
## ASV13153    -1.851221e-04 -1.938487e-04 -2.029810e-04 -2.125371e-04
## ASV7858     -1.643869e-04 -1.721344e-04 -1.802420e-04 -1.887257e-04
## ASV8722      5.476640e-05  5.695068e-05  5.920180e-05  6.151986e-05
## ASV6585     -3.701399e-04 -3.872031e-04 -4.050254e-04 -4.236380e-04
## ASV3311     -3.196704e-04 -3.336125e-04 -3.481034e-04 -3.631595e-04
## ASV2469      5.833357e-06  6.244097e-06  6.684477e-06  7.156520e-06
## ASV11340    -1.589775e-04 -1.659778e-04 -1.732607e-04 -1.808353e-04
## ASV1718      2.992880e-05  3.121010e-05  3.253915e-05  3.391707e-05
## ASV2117     -3.675190e-04 -3.845280e-04 -4.023001e-04 -4.208670e-04
## ASV8252     -2.608984e-04 -2.728965e-04 -2.854267e-04 -2.985106e-04
## ASV8533      5.117828e-05  5.351145e-05  5.594624e-05  5.848666e-05
## ASV9507      3.887473e-05  4.048298e-05  4.214631e-05  4.386551e-05
## ASV0706      1.868170e-04  1.957450e-04  2.051003e-04  2.149034e-04
## ASV10312    -2.608704e-04 -2.728658e-04 -2.853930e-04 -2.984737e-04
## ASV10696    -2.608446e-04 -2.728376e-04 -2.853622e-04 -2.984400e-04
## ASV11203    -2.608189e-04 -2.728095e-04 -2.853314e-04 -2.984064e-04
## ASV12147    -6.302531e-05 -6.608251e-05 -6.928997e-05 -7.265520e-05
## ASV4602     -1.703036e-05 -1.800125e-05 -1.903279e-05 -2.012910e-05
## ASV5568      1.405034e-05  1.479412e-05  1.557951e-05  1.640893e-05
## ASV6777      3.340422e-04  3.494323e-04  3.655073e-04  3.822955e-04
## ASV8749     -2.933109e-04 -3.066221e-04 -3.205073e-04 -3.349885e-04
## ASV4780      4.954937e-05  5.160111e-05  5.372281e-05  5.591541e-05
## ASV10116    -4.931161e-05 -5.154600e-05 -5.387699e-05 -5.630841e-05
## ASV2907      2.842631e-04  2.972708e-04  3.108483e-04  3.250182e-04
## ASV5165      3.723190e-04  3.900140e-04  4.085461e-04  4.279545e-04
## ASV6061      2.061959e-04  2.154884e-04  2.251760e-04  2.352733e-04
## ASV8082     -1.285017e-04 -1.344234e-04 -1.406093e-04 -1.470705e-04
## ASV7696     -1.309053e-04 -1.369476e-04 -1.432603e-04 -1.498547e-04
## ASV0550      2.585851e-05  2.694053e-05  2.806198e-05  2.922389e-05
## ASV7745      1.685256e-04  1.765959e-04  1.850530e-04  1.939154e-04
## ASV3607     -3.452879e-06 -3.549485e-06 -3.644723e-06 -3.738040e-06
## ASV3877     -2.535161e-04 -2.648380e-04 -2.766322e-04 -2.889155e-04
## ASV7667     -1.152788e-04 -1.203451e-04 -1.256158e-04 -1.310975e-04
## ASV9293     -9.749007e-05 -1.020463e-04 -1.068102e-04 -1.117908e-04
## ASV11653    -2.534736e-04 -2.647916e-04 -2.765816e-04 -2.888603e-04
## ASV12850     4.169410e-05  4.386211e-05  4.614679e-05  4.855445e-05
## ASV13104     4.725160e-05  4.918780e-05  5.118793e-05  5.325261e-05
## ASV14208    -2.534547e-04 -2.647711e-04 -2.765592e-04 -2.888359e-04
## ASV1552      2.356891e-04  2.468620e-04  2.585600e-04  2.708073e-04
## ASV2501      1.580452e-04  1.649691e-04  1.721696e-04  1.796556e-04
## ASV2893      3.168074e-04  3.314205e-04  3.466838e-04  3.626239e-04
## ASV3084      1.194027e-04  1.247063e-04  1.302294e-04  1.359796e-04
## ASV3599      1.603037e-04  1.673665e-04  1.747142e-04  1.823560e-04
## ASV3868     -2.534561e-04 -2.647727e-04 -2.765612e-04 -2.888382e-04
## ASV3917     -3.416997e-04 -3.570912e-04 -3.731363e-04 -3.898595e-04
## ASV5695      6.465785e-05  6.779773e-05  7.109141e-05  7.454642e-05
## ASV0131      3.272660e-05  3.384663e-05  3.498254e-05  3.613214e-05
## ASV2847      3.066332e-04  3.200983e-04  3.341035e-04  3.486661e-04
## ASV6875     -2.537164e-04 -2.651869e-04 -2.771478e-04 -2.896177e-04
## ASV1547     -5.234707e-04 -5.469145e-04 -5.713406e-04 -5.967843e-04
## ASV1501     -3.298598e-04 -3.448456e-04 -3.604794e-04 -3.767864e-04
## ASV3876      3.678018e-04  3.846204e-04  4.021751e-04  4.204951e-04
## ASV3456     -3.677657e-04 -3.845809e-04 -4.021320e-04 -4.204480e-04
## ASV1194      3.467573e-04  3.626015e-04  3.791382e-04  3.963949e-04
## ASV2135     -4.449420e-04 -4.655435e-04 -4.870706e-04 -5.095625e-04
## ASV1352      3.676656e-04  3.844714e-04  4.020122e-04  4.203170e-04
## ASV3208      4.183369e-04  4.374902e-04  4.574841e-04  4.783522e-04
## ASV1164      4.009567e-06  4.376430e-06  4.775352e-06  5.208939e-06
## ASV3492      1.764324e-04  1.849083e-04  1.937929e-04  2.031060e-04
## ASV1601      2.023134e-04  2.115505e-04  2.211908e-04  2.312502e-04
## ASV5347     -2.586908e-04 -2.702404e-04 -2.822715e-04 -2.948011e-04
## ASV0293      1.954572e-04  2.044104e-04  2.137567e-04  2.235118e-04
## ASV1509      3.370216e-04  3.523886e-04  3.684234e-04  3.851518e-04
## ASV2801      4.881645e-05  5.097834e-05  5.322914e-05  5.557197e-05
## ASV2873     -7.863145e-05 -8.236309e-05 -8.627129e-05 -9.036437e-05
## ASV2162     -5.240097e-05 -5.473584e-05 -5.716781e-05 -5.970033e-05
## ASV0462      2.022640e-04  2.109419e-04  2.199509e-04  2.293003e-04
## ASV5367     -3.194114e-04 -3.341830e-04 -3.496161e-04 -3.657383e-04
## ASV2715      3.981226e-04  4.161051e-04  4.348549e-04  4.544005e-04
## ASV0371      4.869555e-04  5.084347e-04  5.307885e-04  5.540466e-04
## ASV8090     -3.369083e-04 -3.520277e-04 -3.677832e-04 -3.841978e-04
## ASV6320     -2.642835e-04 -2.766017e-04 -2.894817e-04 -3.029481e-04
## ASV2562      2.777073e-04  2.906863e-04  3.042595e-04  3.184529e-04
## ASV1505     -3.890295e-04 -4.070475e-04 -4.258746e-04 -4.455448e-04
## ASV4924     -2.974110e-04 -3.108802e-04 -3.249267e-04 -3.395724e-04
## ASV1437      3.327809e-04  3.479919e-04  3.638688e-04  3.804379e-04
## ASV3816     -2.119073e-05 -2.185665e-05 -2.252596e-05 -2.319676e-05
## ASV1969     -1.624702e-04 -1.703182e-04 -1.785422e-04 -1.871595e-04
## ASV3146      1.759639e-04  1.836969e-04  1.917408e-04  2.001054e-04
## ASV0321     -1.908504e-04 -1.993566e-04 -2.082173e-04 -2.174452e-04
## ASV1020      3.847596e-04  4.019730e-04  4.199071e-04  4.385879e-04
## ASV4138      2.759750e-05  2.906162e-05  3.060788e-05  3.224108e-05
## ASV0329     -2.137502e-04 -2.235891e-04 -2.338637e-04 -2.445915e-04
## ASV10647     3.873455e-05  4.061814e-05  4.259468e-05  4.466884e-05
## ASV3389      3.182678e-04  3.328574e-04  3.480888e-04  3.639879e-04
## ASV6880      1.693984e-04  1.765083e-04  1.838725e-04  1.914960e-04
## ASV2624     -4.419292e-05 -4.664937e-05 -4.925307e-05 -5.201344e-05
## ASV3686     -6.387274e-05 -6.764534e-05 -7.165958e-05 -7.593176e-05
## ASV12302    -2.663047e-04 -2.788108e-04 -2.918958e-04 -3.055856e-04
## ASV1184      3.245588e-04  3.392793e-04  3.546329e-04  3.706434e-04
## ASV3533     -1.377636e-04 -1.435964e-04 -1.496411e-04 -1.559019e-04
## ASV1735      7.663971e-05  7.986210e-05  8.319959e-05  8.665439e-05
## ASV0483     -1.511351e-04 -1.582319e-04 -1.656558e-04 -1.734213e-04
## ASV0928     -2.997686e-04 -3.136318e-04 -3.281167e-04 -3.432494e-04
## ASV12254    -2.631821e-04 -2.753918e-04 -2.881526e-04 -3.014880e-04
## ASV16025    -2.631560e-04 -2.753632e-04 -2.881212e-04 -3.014537e-04
## ASV3070     -2.631298e-04 -2.753345e-04 -2.880899e-04 -3.014193e-04
## ASV1850      6.224236e-05  6.524968e-05  6.840300e-05  7.170933e-05
## ASV8946     -2.574416e-04 -2.691092e-04 -2.812776e-04 -2.939658e-04
## ASV1536      2.156833e-04  2.254137e-04  2.355575e-04  2.461301e-04
## ASV4151      3.242420e-04  3.387849e-04  3.539394e-04  3.697276e-04
## ASV4585      4.353633e-04  4.548813e-04  4.752186e-04  4.964045e-04
## ASV4921     -1.050068e-04 -1.096229e-04 -1.144226e-04 -1.194114e-04
## ASV6172      2.573728e-04  2.690340e-04  2.811955e-04  2.938763e-04
## ASV6375     -2.573477e-04 -2.690067e-04 -2.811657e-04 -2.938437e-04
## ASV6501      2.913922e-04  3.041832e-04  3.174884e-04  3.313243e-04
## ASV17095    -2.573282e-04 -2.689853e-04 -2.811424e-04 -2.938182e-04
## ASV3679     -2.573032e-04 -2.689580e-04 -2.811125e-04 -2.937856e-04
## ASV5750      2.572782e-04  2.689307e-04  2.810827e-04  2.937531e-04
## ASV5922     -2.572532e-04 -2.689034e-04 -2.810529e-04 -2.937205e-04
## ASV7323     -2.572283e-04 -2.688761e-04 -2.810231e-04 -2.936879e-04
## ASV8515     -3.810914e-06 -4.036289e-06 -4.275000e-06 -4.527731e-06
## ASV8753     -2.572029e-04 -2.688484e-04 -2.809928e-04 -2.936549e-04
## ASV9197      1.769308e-04  1.849957e-04  1.934107e-04  2.021893e-04
## ASV1778      4.894792e-05  5.142623e-05  5.403507e-05  5.678163e-05
## ASV1241      3.313468e-04  3.461979e-04  3.616723e-04  3.777924e-04
## ASV1717      2.594496e-04  2.712207e-04  2.834992e-04  2.963047e-04
## ASV1112      2.963158e-04  3.092915e-04  3.227841e-04  3.368098e-04
## ASV3994      3.500434e-04  3.661311e-04  3.829288e-04  4.004649e-04
## ASV5511     -2.587781e-04 -2.705731e-04 -2.828809e-04 -2.957216e-04
## ASV8706      1.892977e-04  1.982546e-04  2.076315e-04  2.174475e-04
## ASV3049     -2.587577e-04 -2.705509e-04 -2.828566e-04 -2.956951e-04
## ASV4332      1.668693e-04  1.746547e-04  1.827947e-04  1.913044e-04
## ASV7411      2.919915e-04  3.049090e-04  3.183528e-04  3.323405e-04
## ASV7475     -2.587473e-04 -2.705394e-04 -2.828442e-04 -2.956815e-04
## ASV8988     -2.587220e-04 -2.705118e-04 -2.828140e-04 -2.956485e-04
## ASV0688     -5.499707e-04 -5.743102e-04 -5.996434e-04 -6.260035e-04
## ASV1946      1.475586e-04  1.538212e-04  1.603155e-04  1.670473e-04
## ASV3150      4.290954e-04  4.483859e-04  4.684904e-04  4.894383e-04
## ASV3508      2.085769e-04  2.176400e-04  2.270573e-04  2.368388e-04
## ASV3863     -2.587040e-04 -2.704920e-04 -2.827923e-04 -2.956248e-04
## ASV4544      2.018103e-04  2.105661e-04  2.196627e-04  2.291098e-04
## ASV4567      4.665119e-04  4.876949e-04  5.097922e-04  5.328388e-04
## ASV4855     -2.586777e-04 -2.704633e-04 -2.827609e-04 -2.955905e-04
## ASV4872      3.440980e-04  3.594937e-04  3.755324e-04  3.922366e-04
## ASV4881      2.497265e-04  2.614306e-04  2.736736e-04  2.864792e-04
## ASV5283      2.586571e-04  2.704408e-04  2.827363e-04  2.955636e-04
## ASV5302      3.050697e-04  3.188589e-04  3.332409e-04  3.482390e-04
## ASV5909      2.593068e-04  2.710586e-04  2.833148e-04  2.960944e-04
## ASV5933      1.937065e-04  2.025217e-04  2.117185e-04  2.213116e-04
## ASV6019      2.846144e-04  2.969958e-04  3.098637e-04  3.232328e-04
## ASV6043      1.159125e-04  1.213872e-04  1.271175e-04  1.331149e-04
## ASV6908      3.239842e-04  3.386761e-04  3.539999e-04  3.699794e-04
## ASV7245     -2.586708e-04 -2.704557e-04 -2.827526e-04 -2.955813e-04
## ASV7249     -2.586455e-04 -2.704281e-04 -2.827224e-04 -2.955484e-04
## ASV8349      8.744386e-05  9.150743e-05  9.575481e-05  1.001938e-04
## ASV7310     -2.586248e-04 -2.704054e-04 -2.826976e-04 -2.955213e-04
## ASV1893      1.999684e-04  2.089359e-04  2.182821e-04  2.280210e-04
## ASV2354      1.525009e-04  1.590002e-04  1.657433e-04  1.727366e-04
## ASV3435     -4.257127e-05 -4.433381e-05 -4.615680e-05 -4.804115e-05
## ASV0480      4.033496e-04  4.221474e-04  4.417987e-04  4.623399e-04
## ASV0955     -1.400988e-04 -1.466285e-04 -1.534559e-04 -1.605940e-04
## ASV10000     7.687273e-05  7.991489e-05  8.304803e-05  8.627211e-05
## ASV7215     -1.681049e-04 -1.759839e-04 -1.842247e-04 -1.928430e-04
## ASV10423    -3.660549e-04 -3.827089e-04 -4.000838e-04 -4.182075e-04
## ASV6008     -1.956651e-04 -2.045946e-04 -2.139130e-04 -2.236357e-04
## ASV9330     -3.660025e-04 -3.826515e-04 -4.000211e-04 -4.181391e-04
## ASV6051      3.659668e-04  3.826125e-04  3.999785e-04  4.180925e-04
## ASV1675      2.418729e-04  2.528586e-04  2.643181e-04  2.762696e-04
## ASV2043      1.577853e-04  1.652117e-04  1.729831e-04  1.811148e-04
## ASV3634      1.490717e-04  1.562545e-04  1.637862e-04  1.716842e-04
## ASV4077     -3.659498e-04 -3.825940e-04 -3.999583e-04 -4.180706e-04
## ASV4754      1.766404e-04  1.845501e-04  1.927910e-04  2.013749e-04
## ASV6095      4.182518e-04  4.368322e-04  4.561792e-04  4.763193e-04
## ASV6288      3.098034e-04  3.236760e-04  3.381288e-04  3.531825e-04
## ASV6507     -3.659278e-04 -3.825700e-04 -3.999321e-04 -4.180419e-04
## ASV8905      1.853643e-04  1.936638e-04  2.023112e-04  2.113190e-04
## ASV9728     -3.658982e-04 -3.825376e-04 -3.998967e-04 -4.180032e-04
## ASV11144    -3.658625e-04 -3.824986e-04 -3.998541e-04 -4.179566e-04
## ASV1615     -1.475950e-04 -1.544154e-04 -1.615403e-04 -1.689823e-04
## ASV2709     -4.460547e-04 -4.662793e-04 -4.873733e-04 -5.093694e-04
## ASV3003      3.547066e-04  3.710540e-04  3.881295e-04  4.059634e-04
## ASV5163     -3.371388e-04 -3.524477e-04 -3.684167e-04 -3.850708e-04
## ASV6622      2.378082e-04  2.488748e-04  2.604439e-04  2.725373e-04
## ASV1076     -3.496119e-04 -3.655967e-04 -3.822810e-04 -3.996926e-04
## ASV7895      8.208864e-05  8.564088e-05  8.932985e-05  9.315921e-05
## ASV10577    -2.661712e-04 -2.786658e-04 -2.917383e-04 -3.054148e-04
## ASV1272      2.661444e-04  2.786364e-04  2.917062e-04  3.053795e-04
## ASV2492     -1.334675e-04 -1.402543e-04 -1.474016e-04 -1.549296e-04
## ASV5195      3.185543e-04  3.331847e-04  3.484621e-04  3.644129e-04
## ASV5267      1.910668e-04  1.996140e-04  2.085174e-04  2.177895e-04
## ASV6317      2.717471e-04  2.843848e-04  2.975949e-04  3.114021e-04
## ASV2296      9.755750e-05  1.020633e-04  1.067717e-04  1.116916e-04
## ASV2290     -2.378304e-04 -2.484060e-04 -2.594183e-04 -2.708823e-04
## ASV3726      2.086420e-04  2.184809e-04  2.287780e-04  2.395542e-04
## ASV1169      1.752768e-04  1.831946e-04  1.914506e-04  2.000575e-04
## ASV0189     -1.691106e-04 -1.771137e-04 -1.854921e-04 -1.942631e-04
## ASV2729      6.388601e-04  6.687254e-04  6.999565e-04  7.326128e-04
## ASV3469      1.450244e-04  1.517286e-04  1.587334e-04  1.660514e-04
## ASV0762     -3.434188e-04 -3.586852e-04 -3.745806e-04 -3.911264e-04
## ASV9001     -3.159915e-04 -3.295598e-04 -3.436496e-04 -3.582762e-04
## ASV14604    -2.563141e-04 -2.678801e-04 -2.799383e-04 -2.925068e-04
## ASV7439      7.697399e-05  8.076507e-05  8.474756e-05  8.893144e-05
## ASV8625     -2.562937e-04 -2.678579e-04 -2.799141e-04 -2.924805e-04
## ASV11553     5.118805e-05  5.375070e-05  5.644632e-05  5.928210e-05
## ASV14440     4.848999e-06  4.594840e-06  4.288188e-06  3.923538e-06
## ASV16106    -2.562720e-04 -2.678341e-04 -2.798881e-04 -2.924520e-04
## ASV16110    -2.562472e-04 -2.678070e-04 -2.798585e-04 -2.924198e-04
## ASV2229      4.507978e-04  4.707326e-04  4.914803e-04  5.130681e-04
## ASV3854     -2.480124e-04 -2.592068e-04 -2.708777e-04 -2.830430e-04
## ASV5512     -2.562137e-04 -2.677705e-04 -2.798186e-04 -2.923761e-04
## ASV5939      3.446415e-04  3.603387e-04  3.767172e-04  3.938033e-04
## ASV6676     -1.771295e-04 -1.851260e-04 -1.934631e-04 -2.021533e-04
## ASV8381     -2.561578e-04 -2.677094e-04 -2.797518e-04 -2.923033e-04
## ASV2735      3.268919e-04  3.418645e-04  3.574940e-04  3.738063e-04
## ASV9816     -2.561412e-04 -2.676913e-04 -2.797321e-04 -2.922817e-04
## ASV1382      1.145209e-04  1.194816e-04  1.246356e-04  1.299887e-04
## ASV1408     -2.572885e-04 -2.689522e-04 -2.811179e-04 -2.938049e-04
## ASV4902      1.654301e-04  1.734612e-04  1.818872e-04  1.907277e-04
## ASV5600      1.988299e-04  2.078103e-04  2.171744e-04  2.269365e-04
## ASV0815     -5.510000e-05 -5.744484e-05 -5.987653e-05 -6.239714e-05
## ASV11867    -2.572759e-04 -2.689386e-04 -2.811030e-04 -2.937886e-04
## ASV16064    -2.572509e-04 -2.689112e-04 -2.810732e-04 -2.937560e-04
## ASV2250      3.238901e-04  3.387664e-04  3.543005e-04  3.705192e-04
## ASV2417      7.662066e-05  8.035394e-05  8.427139e-05  8.838216e-05
## ASV2807      4.179782e-04  4.363894e-04  4.555457e-04  4.754719e-04
## ASV3224     -2.571938e-04 -2.688489e-04 -2.810052e-04 -2.936819e-04
## ASV4115     -2.571688e-04 -2.688216e-04 -2.809754e-04 -2.936493e-04
## ASV4876      4.190247e-05  4.374000e-05  4.564981e-05  4.763391e-05
## ASV5291      2.496247e-04  2.607308e-04  2.722948e-04  2.843324e-04
## ASV5834      1.214701e-04  1.269806e-04  1.327277e-04  1.387203e-04
## ASV6896      2.779485e-05  2.892422e-05  3.008977e-05  3.129170e-05
## ASV7292     -2.571531e-04 -2.688044e-04 -2.809566e-04 -2.936288e-04
## ASV7924      1.483990e-04  1.552676e-04  1.624445e-04  1.699425e-04
## ASV0710      3.395098e-04  3.547197e-04  3.705662e-04  3.870720e-04
## ASV1925      2.950353e-04  3.081224e-04  3.217460e-04  3.359242e-04
## ASV4247     -2.571261e-04 -2.687749e-04 -2.809244e-04 -2.935937e-04
## ASV4549     -2.571011e-04 -2.687476e-04 -2.808946e-04 -2.935611e-04
## ASV4076      2.152951e-04  2.250733e-04  2.352745e-04  2.459151e-04
## ASV7063      2.095970e-04  2.192295e-04  2.292868e-04  2.397860e-04
## ASV1487      2.205299e-04  2.301872e-04  2.402293e-04  2.506684e-04
## ASV1405      9.295904e-05  9.741280e-05  1.020800e-04  1.069708e-04
## ASV3851      2.296045e-04  2.403434e-04  2.515732e-04  2.633150e-04
## ASV0896      6.986957e-05  7.309171e-05  7.645767e-05  7.997346e-05
## ASV5581      3.344237e-04  3.501702e-04  3.666488e-04  3.838925e-04
## ASV7053     -1.095738e-04 -1.145770e-04 -1.197988e-04 -1.252479e-04
## ASV7171     -2.638177e-04 -2.760899e-04 -2.889195e-04 -3.023305e-04
## ASV4017     -3.608117e-04 -3.775009e-04 -3.949390e-04 -4.131573e-04
## ASV5846      1.993200e-05  2.019589e-05  2.041442e-05  2.058097e-05
## ASV0203      1.554701e-06  1.437209e-06  1.301901e-06  1.147507e-06
## ASV13271     3.991838e-05  4.149831e-05  4.312567e-05  4.480047e-05
## ASV9487      1.619577e-04  1.686094e-04  1.754875e-04  1.825957e-04
## ASV2056     -3.693177e-04 -3.863066e-04 -4.040485e-04 -4.225743e-04
## ASV16933    -3.622497e-04 -3.785699e-04 -3.955837e-04 -4.133168e-04
## ASV0360      1.565576e-04  1.633993e-04  1.705139e-04  1.779101e-04
## ASV1798     -2.355553e-04 -2.461568e-04 -2.572075e-04 -2.687239e-04
## ASV17286    -2.634664e-04 -2.757017e-04 -2.884904e-04 -3.018560e-04
## ASV8175     -2.634402e-04 -2.756730e-04 -2.884589e-04 -3.018216e-04
## ASV6679      2.774922e-04  2.899914e-04  3.030202e-04  3.165981e-04
## ASV6776      1.333042e-04  1.391521e-04  1.452333e-04  1.515551e-04
## ASV9062     -2.634163e-04 -2.756469e-04 -2.884303e-04 -3.017902e-04
## ASV9564     -2.391995e-05 -2.518839e-05 -2.652901e-05 -2.794630e-05
## ASV6431     -2.633881e-04 -2.756160e-04 -2.883964e-04 -3.017531e-04
## ASV9940      1.069007e-04  1.117170e-04  1.167368e-04  1.219675e-04
## ASV7001     -3.628312e-04 -3.791912e-04 -3.962463e-04 -4.140222e-04
## ASV3044      4.097146e-04  4.281910e-04  4.474540e-04  4.675330e-04
## ASV6684      1.531884e-04  1.605672e-04  1.683036e-04  1.764148e-04
## ASV12278     2.868581e-06  3.129478e-06  3.413213e-06  3.721661e-06
## ASV3543     -2.409430e-04 -2.513920e-04 -2.622501e-04 -2.735299e-04
## ASV6397      2.863355e-06  3.123759e-06  3.406955e-06  3.714816e-06
## ASV9939      2.862818e-06  3.123148e-06  3.406259e-06  3.714023e-06
## ASV9432      2.132859e-04  2.233481e-04  2.338793e-04  2.449008e-04
## ASV2630     -2.648011e-04 -2.771717e-04 -2.901080e-04 -3.036348e-04
## ASV2175      3.476797e-04  3.639508e-04  3.809696e-04  3.987691e-04
## ASV4107      2.861227e-04  2.993545e-04  3.131789e-04  3.276207e-04
## ASV9172     -3.727817e-05 -3.923551e-05 -4.130243e-05 -4.348557e-05
## ASV3141      3.415733e-04  3.576625e-04  3.745004e-04  3.921208e-04
## ASV9010     -2.642352e-04 -2.765443e-04 -2.894138e-04 -3.028680e-04
## ASV2550      2.607462e-04  2.726189e-04  2.850065e-04  2.979290e-04
## ASV5845     -2.642171e-04 -2.765245e-04 -2.893920e-04 -3.028441e-04
## ASV3998      2.641907e-04  2.764956e-04  2.893604e-04  3.028094e-04
## ASV1389     -2.810822e-04 -2.930975e-04 -3.055690e-04 -3.185096e-04
## ASV0615     -2.971710e-04 -3.107097e-04 -3.248375e-04 -3.395774e-04
## ASV9127     -3.640378e-04 -3.805560e-04 -3.977859e-04 -4.157546e-04
## ASV1190      5.155615e-04  5.384002e-04  5.621737e-04  5.869135e-04
## ASV1211      1.304412e-04  1.363679e-04  1.425521e-04  1.490042e-04
## ASV1766     -3.748300e-04 -3.919737e-04 -4.098681e-04 -4.285427e-04
## ASV2337      2.611719e-04  2.731840e-04  2.857280e-04  2.988252e-04
## ASV2463      5.622065e-05  5.880274e-05  6.149861e-05  6.431281e-05
## ASV2806      1.936262e-04  2.021869e-04  2.110993e-04  2.203758e-04
## ASV0439     -3.360379e-04 -3.514023e-04 -3.674385e-04 -3.841729e-04
## ASV0839      3.217146e-04  3.368603e-04  3.527081e-04  3.692891e-04
## ASV14975    -2.611263e-04 -2.731342e-04 -2.856734e-04 -2.987656e-04
## ASV17712    -2.611006e-04 -2.731060e-04 -2.856426e-04 -2.987319e-04
## ASV2010     -2.942129e-05 -3.068955e-05 -3.200555e-05 -3.337039e-05
## ASV2041      1.379843e-04  1.446617e-04  1.516644e-04  1.590080e-04
## ASV2124     -3.370607e-04 -3.526135e-04 -3.688596e-04 -3.858277e-04
## ASV2585      4.654969e-04  4.867109e-04  5.088465e-04  5.319394e-04
## ASV3314      3.696561e-04  3.868379e-04  4.047979e-04  4.235696e-04
## ASV5051     -3.316112e-05 -3.444279e-05 -3.575780e-05 -3.710526e-05
## ASV10784     1.306108e-04  1.365049e-04  1.426502e-04  1.490560e-04
## ASV3279     -2.610384e-04 -2.730380e-04 -2.855682e-04 -2.986505e-04
## ASV9498      1.746470e-05  1.807916e-05  1.870412e-05  1.933858e-05
## ASV1059     -2.793436e-04 -2.924066e-04 -3.060688e-04 -3.203565e-04
## ASV13008    -2.610120e-04 -2.730090e-04 -2.855365e-04 -2.986158e-04
## ASV15803    -2.609862e-04 -2.729809e-04 -2.855057e-04 -2.985821e-04
## ASV2559     -2.533531e-04 -2.650104e-04 -2.771844e-04 -2.898964e-04
## ASV2623     -2.609612e-04 -2.729535e-04 -2.854757e-04 -2.985493e-04
## ASV2802     -1.463480e-04 -1.529786e-04 -1.598941e-04 -1.671051e-04
## ASV3799      3.999870e-04  4.181285e-04  4.370512e-04  4.567850e-04
## ASV5274     -1.026133e-06 -1.236060e-06 -1.469872e-06 -1.729819e-06
## ASV5835      1.616190e-04  1.692358e-04  1.772081e-04  1.855523e-04
## ASV7251     -2.609553e-04 -2.729470e-04 -2.854686e-04 -2.985416e-04
## ASV7616     -2.609296e-04 -2.729189e-04 -2.854379e-04 -2.985079e-04
## ASV9576     -2.609039e-04 -2.728908e-04 -2.854071e-04 -2.984743e-04
## ASV2870      1.912820e-04  2.000918e-04  2.092924e-04  2.188999e-04
## ASV3668     -1.684661e-04 -1.763191e-04 -1.845291e-04 -1.931114e-04
## ASV1633      1.276709e-04  1.336915e-04  1.399925e-04  1.465865e-04
## ASV6060     -6.846333e-06 -7.666478e-06 -8.566220e-06 -9.552292e-06
## ASV6305      1.318848e-04  1.380793e-04  1.445601e-04  1.513400e-04
## ASV5164      8.437200e-05  8.797854e-05  9.171982e-05  9.559908e-05
## ASV7252     -2.616389e-04 -2.737018e-04 -2.863020e-04 -2.994618e-04
## ASV9343      2.268284e-04  2.376397e-04  2.489655e-04  2.608301e-04
## ASV6835     -4.348031e-05 -4.540776e-05 -4.741401e-05 -4.950170e-05
## ASV1264      3.178236e-04  3.322724e-04  3.473472e-04  3.630725e-04
## ASV0591      2.632884e-05  2.705967e-05  2.778072e-05  2.848802e-05
## ASV1351      3.680226e-04  3.850094e-04  4.027546e-04  4.212896e-04
## ASV14224    -2.615752e-04 -2.736321e-04 -2.862258e-04 -2.993784e-04
## ASV1432     -2.615493e-04 -2.736038e-04 -2.861948e-04 -2.993445e-04
## ASV1559     -2.195114e-04 -2.297201e-04 -2.403914e-04 -2.515452e-04
## ASV2182      4.052713e-04  4.236754e-04  4.428738e-04  4.628970e-04
## ASV2304     -2.149390e-05 -2.239948e-05 -2.333759e-05 -2.430888e-05
## ASV6838     -2.161411e-06 -2.236751e-06 -2.313330e-06 -2.391023e-06
## ASV1125     -3.955434e-05 -4.147696e-05 -4.349427e-05 -4.561099e-05
## ASV17948    -2.615400e-04 -2.735936e-04 -2.861837e-04 -2.993324e-04
## ASV2609      2.311412e-04  2.419212e-04  2.531927e-04  2.649769e-04
## ASV6128     -2.147418e-04 -2.246854e-04 -2.350698e-04 -2.459121e-04
## ASV1338      5.010806e-05  5.198192e-05  5.390041e-05  5.586204e-05
## ASV2136      9.389675e-05  9.792550e-05  1.021074e-04  1.064467e-04
## ASV0929     -2.379800e-04 -2.487361e-04 -2.599526e-04 -2.716469e-04
## ASV3479      1.637055e-04  1.709743e-04  1.785414e-04  1.864166e-04
## ASV0886      4.389246e-04  4.590072e-04  4.799697e-04  5.018469e-04
## ASV1652      2.018513e-04  2.111812e-04  2.209294e-04  2.311133e-04
## ASV1160      3.646699e-04  3.814825e-04  3.990439e-04  4.173851e-04
## ASV5260     -6.999917e-05 -7.352348e-05 -7.723106e-05 -8.113172e-05
## ASV2352      4.441266e-04  4.636893e-04  4.840445e-04  5.052184e-04
## ASV0986     -1.765592e-04 -1.844524e-04 -1.926757e-04 -2.012410e-04
## ASV2021      2.935855e-04  3.069056e-04  3.207996e-04  3.352896e-04
## ASV16599    -2.438086e-04 -2.557375e-04 -2.682556e-04 -2.813917e-04
## ASV3497      2.239874e-04  2.343909e-04  2.452658e-04  2.566326e-04
## ASV1305      1.517431e-04  1.590666e-04  1.667433e-04  1.747898e-04
## ASV0927     -3.385671e-04 -3.528805e-04 -3.677177e-04 -3.830909e-04
## ASV0647     -1.107256e-04 -1.152177e-04 -1.198554e-04 -1.246401e-04
## ASV1832     -1.457573e-04 -1.523209e-04 -1.591631e-04 -1.662944e-04
## ASV1277      1.738813e-04  1.817833e-04  1.900268e-04  1.986249e-04
## ASV22332    -2.622849e-04 -2.744079e-04 -2.870738e-04 -3.003052e-04
## ASV10080    -3.527180e-05 -3.753107e-05 -3.994556e-05 -4.252612e-05
## ASV14157     3.563352e-05  3.738705e-05  3.922888e-05  4.116358e-05
## ASV15829    -2.622578e-04 -2.743782e-04 -2.870411e-04 -3.002693e-04
## ASV3609     -2.622318e-04 -2.743497e-04 -2.870100e-04 -3.002353e-04
## ASV5737      5.735398e-05  5.973357e-05  6.219481e-05  6.473887e-05
## ASV1474      1.914941e-04  2.004011e-04  2.097106e-04  2.194398e-04
## ASV2028      2.575359e-04  2.684263e-04  2.797155e-04  2.914128e-04
## ASV0818      3.146761e-04  3.290697e-04  3.440933e-04  3.597718e-04
## ASV0505     -2.730743e-04 -2.857629e-04 -2.990239e-04 -3.128814e-04
## ASV1813      1.272432e-04  1.327407e-04  1.384501e-04  1.443770e-04
## ASV0512      2.844982e-04  2.979468e-04  3.120189e-04  3.267417e-04
## ASV5374     -2.006376e-04 -2.099073e-04 -2.195932e-04 -2.297130e-04
## ASV2927     -2.368336e-05 -2.421523e-05 -2.471944e-05 -2.519022e-05
## ASV3596      1.951564e-04  2.037207e-04  2.126273e-04  2.218870e-04
## ASV1137      1.161176e-04  1.211041e-04  1.262786e-04  1.316458e-04
## ASV4541      3.546806e-06  3.872144e-06  4.226340e-06  4.611820e-06
## ASV9872     -3.546137e-06 -3.871380e-06 -4.225469e-06 -4.610827e-06
## ASV0359     -9.127678e-05 -9.524725e-05 -9.937305e-05 -1.036587e-04
## ASV0720     -1.561960e-04 -1.630863e-04 -1.702547e-04 -1.777102e-04
## ASV10545    -3.560921e-06 -3.887454e-06 -4.242938e-06 -4.629802e-06
## ASV13384    -3.560249e-06 -3.886687e-06 -4.242064e-06 -4.628806e-06
## ASV1456      6.744695e-06  7.023505e-06  7.311973e-06  7.610274e-06
## ASV1751     -3.559957e-06 -3.886333e-06 -4.241637e-06 -4.628294e-06
## ASV18419    -3.559286e-06 -3.885567e-06 -4.240763e-06 -4.627297e-06
## ASV2970      3.558614e-06  3.884801e-06  4.239889e-06  4.626302e-06
## ASV4215      2.043332e-04  2.136665e-04  2.234068e-04  2.335701e-04
## ASV4742      3.307208e-05  3.432721e-05  3.561445e-05  3.693311e-05
## ASV5017      6.396319e-05  6.675369e-05  6.965425e-05  7.266819e-05
## ASV5139     -3.554113e-06 -3.879774e-06 -4.234275e-06 -4.620030e-06
## ASV9133     -3.553443e-06 -3.879010e-06 -4.233403e-06 -4.619036e-06
## ASV9447     -3.552773e-06 -3.878245e-06 -4.232531e-06 -4.618042e-06
## ASV0842     -1.918798e-04 -2.000232e-04 -2.084691e-04 -2.172250e-04
## ASV12293     1.338814e-04  1.394005e-04  1.451089e-04  1.510098e-04
## ASV1965      2.463275e-04  2.577600e-04  2.697091e-04  2.821970e-04
## ASV2005      2.655812e-04  2.768806e-04  2.886005e-04  3.007514e-04
## ASV5335      1.982291e-04  2.068149e-04  2.157335e-04  2.249945e-04
## ASV6438     -3.589196e-06 -3.917862e-06 -4.275603e-06 -4.664853e-06
## ASV7798     -3.588520e-06 -3.917090e-06 -4.274724e-06 -4.663850e-06
## ASV2691     -2.770962e-04 -2.898929e-04 -3.032606e-04 -3.172230e-04
## ASV9958      2.255772e-04  2.357098e-04  2.462695e-04  2.572717e-04
## ASV1512      8.275790e-05  8.671431e-05  9.086066e-05  9.520614e-05
## ASV1226      3.711651e-04  3.880389e-04  4.056437e-04  4.240079e-04
## ASV2130     -6.546687e-04 -6.843876e-04 -7.153885e-04 -7.477207e-04
## ASV0874     -2.035616e-04 -2.127550e-04 -2.223435e-04 -2.323424e-04
## ASV5436     -2.919338e-04 -3.053468e-04 -3.193520e-04 -3.339734e-04
## ASV0383     -3.187006e-04 -3.324406e-04 -3.467085e-04 -3.615189e-04
## ASV1882      3.117745e-04  3.252482e-04  3.392455e-04  3.537818e-04
## ASV2471     -1.774289e-04 -1.854688e-04 -1.938544e-04 -2.025987e-04
## ASV4049     -2.518250e-04 -2.631678e-04 -2.749916e-04 -2.873140e-04
## ASV3014     -1.403650e-04 -1.465013e-04 -1.528812e-04 -1.595120e-04
## ASV0316     -5.052417e-04 -5.281970e-04 -5.521442e-04 -5.771216e-04
## ASV1621     -3.496152e-04 -3.652385e-04 -3.815140e-04 -3.984649e-04
## ASV13266    -2.571576e-04 -2.688051e-04 -2.809527e-04 -2.936192e-04
## ASV1635     -2.549826e-04 -2.665276e-04 -2.785678e-04 -2.911220e-04
## ASV2042      1.873486e-04  1.958471e-04  2.047117e-04  2.139566e-04
## ASV2317     -3.054451e-04 -3.192205e-04 -3.335819e-04 -3.485510e-04
## ASV3697      2.303077e-04  2.405367e-04  2.511871e-04  2.622732e-04
## ASV6404      4.233936e-04  4.420895e-04  4.615474e-04  4.817931e-04
## ASV15616     1.837037e-05  1.943191e-05  2.056016e-05  2.175958e-05
## ASV10783    -2.571042e-04 -2.687468e-04 -2.808890e-04 -2.935496e-04
## ASV6912     -1.926889e-04 -2.013467e-04 -2.103698e-04 -2.197712e-04
## ASV1561      5.198649e-04  5.429485e-04  5.669828e-04  5.920005e-04
## ASV4404      3.552657e-04  3.713099e-04  3.880387e-04  4.054779e-04
## ASV1110      2.605030e-04  2.721496e-04  2.842823e-04  2.969181e-04
## ASV2844     -8.913319e-05 -9.340197e-05 -9.787528e-05 -1.025629e-04
## ASV5224      2.603616e-04  2.721089e-04  2.843557e-04  2.971203e-04
## ASV6300     -2.618728e-04 -2.739561e-04 -2.865786e-04 -2.997623e-04
## ASV8078     -2.618469e-04 -2.739278e-04 -2.865475e-04 -2.997284e-04
## ASV9722      1.861176e-07 -1.037935e-07 -4.337755e-07 -8.079016e-07
## ASV6911     -2.618206e-04 -2.738990e-04 -2.865160e-04 -2.996938e-04
## ASV5474     -5.400646e-05 -5.661838e-05 -5.935766e-05 -6.223052e-05
## ASV2761     -6.118816e-04 -6.395049e-04 -6.683058e-04 -6.983282e-04
## ASV5943     -1.717347e-04 -1.799956e-04 -1.886565e-04 -1.977370e-04
## ASV0600     -4.280498e-05 -4.423689e-05 -4.568508e-05 -4.714625e-05
## ASV0608     -5.485460e-04 -5.731740e-04 -5.988411e-04 -6.255853e-04
## ASV1586      1.316083e-04  1.373518e-04  1.433237e-04  1.495312e-04
## ASV0206     -6.074107e-04 -6.341008e-04 -6.618632e-04 -6.907322e-04
## ASV4042     -2.795036e-04 -2.921877e-04 -3.054185e-04 -3.192167e-04
## ASV5304     -8.596866e-06 -9.066816e-06 -9.563414e-06 -1.008813e-05
## ASV0949     -9.938789e-05 -1.045923e-04 -1.100832e-04 -1.158773e-04
## ASV1856      3.220613e-04  3.367094e-04  3.519912e-04  3.679311e-04
## ASV2584      3.747184e-05  3.900090e-05  4.057855e-05  4.220486e-05
## ASV2287     -1.768440e-05 -1.899696e-05 -2.040882e-05 -2.192711e-05
## ASV2364     -4.564236e-04 -4.770087e-04 -4.984703e-04 -5.208410e-04
## ASV11481    -3.656749e-04 -3.827529e-04 -4.006115e-04 -4.192848e-04
## ASV2906     -1.273532e-04 -1.333378e-04 -1.395989e-04 -1.461487e-04
## ASV0161     -1.512813e-04 -1.580891e-04 -1.651848e-04 -1.725787e-04
## ASV0062     -9.946046e-04 -1.039469e-03 -1.086242e-03 -1.134994e-03
## ASV3811     -2.322958e-04 -2.419670e-04 -2.519829e-04 -2.623512e-04
## ASV0225      3.784315e-05  3.911729e-05  4.040892e-05  4.171574e-05
## ASV4672     -3.181401e-04 -3.322781e-04 -3.469994e-04 -3.623241e-04
## ASV1607     -2.449741e-05 -2.566298e-05 -2.688143e-05 -2.815475e-05
## ASV3060      6.369720e-05  6.677246e-05  6.999758e-05  7.337994e-05
## ASV2275     -4.554810e-05 -4.761283e-05 -4.976618e-05 -5.201149e-05
## ASV5375      1.792797e-04  1.877088e-04  1.965286e-04  2.057565e-04
## ASV0352     -5.345579e-04 -5.592763e-04 -5.851024e-04 -6.120825e-04
## ASV1107      1.548007e-04  1.621697e-04  1.698851e-04  1.779626e-04
## ASV4887      1.373422e-04  1.431901e-04  1.492552e-04  1.555428e-04
## ASV2397     -6.868922e-05 -7.144117e-05 -7.427868e-05 -7.720210e-05
## ASV7541     -1.668871e-04 -1.743598e-04 -1.821450e-04 -1.902536e-04
## ASV7387     -3.659175e-04 -3.825733e-04 -3.999508e-04 -4.180776e-04
## ASV1355      3.360763e-04  3.515325e-04  3.676747e-04  3.845312e-04
## ASV1764     -1.746383e-04 -1.824709e-04 -1.906333e-04 -1.991374e-04
## ASV1960     -3.183679e-04 -3.317577e-04 -3.456352e-04 -3.600121e-04
## ASV0484     -6.183553e-05 -6.464445e-05 -6.757505e-05 -7.063211e-05
## ASV2487      9.829349e-05  1.022472e-04  1.063265e-04  1.105323e-04
## ASV0422      3.101654e-04  3.234352e-04  3.372101e-04  3.515042e-04
## ASV0081     -1.970602e-04 -2.063799e-04 -2.161366e-04 -2.263503e-04
## ASV1341     -1.675794e-04 -1.747864e-04 -1.822686e-04 -1.900333e-04
## ASV1001     -3.970208e-04 -4.142262e-04 -4.321009e-04 -4.506643e-04
## ASV0317     -9.779862e-05 -1.025415e-04 -1.075133e-04 -1.127247e-04
## ASV2728     -2.776103e-04 -2.902060e-04 -3.033450e-04 -3.170482e-04
## ASV0884     -3.590023e-04 -3.761362e-04 -3.940851e-04 -4.128871e-04
## ASV0464      7.875567e-05  8.305798e-05  8.761234e-05  9.243447e-05
## ASV2963      2.422055e-04  2.529377e-04  2.641109e-04  2.757404e-04
## ASV4608      1.097850e-04  1.147560e-04  1.199398e-04  1.253444e-04
## ASV3534      2.697595e-04  2.811820e-04  2.930244e-04  3.052964e-04
## ASV0291     -2.340061e-04 -2.444085e-04 -2.552392e-04 -2.665126e-04
## ASV0635     -3.400278e-04 -3.558487e-04 -3.723879e-04 -3.896764e-04
## ASV0867      2.745714e-04  2.875876e-04  3.012166e-04  3.154867e-04
## ASV1206     -3.106879e-05 -3.231115e-05 -3.359144e-05 -3.490969e-05
## ASV1230     -2.368500e-06 -2.590619e-06 -2.833097e-06 -3.097731e-06
## ASV1265      7.254124e-05  7.582944e-05  7.925935e-05  8.283647e-05
## ASV1291     -2.249657e-04 -2.354511e-04 -2.464139e-04 -2.578747e-04
## ASV1524      4.596095e-04  4.797414e-04  5.006766e-04  5.224404e-04
## ASV2153     -3.546348e-04 -3.701804e-04 -3.863491e-04 -4.031610e-04
## ASV2714      2.332129e-06  2.551002e-06  2.789958e-06  3.050772e-06
## ASV4246     -2.331680e-06 -2.550488e-06 -2.789370e-06 -3.050100e-06
## ASV0945      2.373984e-04  2.481561e-04  2.593753e-04  2.710736e-04
## ASV2380      5.487158e-04  5.728143e-04  5.978821e-04  6.239506e-04
## ASV0214     -7.999871e-05 -8.284905e-05 -8.575445e-05 -8.871140e-05
## ASV10461    -2.371347e-06 -2.593793e-06 -2.836635e-06 -3.101675e-06
## ASV4177      1.593676e-04  1.660428e-04  1.729562e-04  1.801127e-04
## ASV0237     -4.006878e-04 -4.192357e-04 -4.386160e-04 -4.588635e-04
## ASV11323    -4.519114e-04 -4.726467e-04 -4.942975e-04 -5.169010e-04
## ASV2232     -7.733605e-05 -8.068562e-05 -8.416508e-05 -8.777813e-05
## ASV0115     -1.454087e-04 -1.520069e-04 -1.588885e-04 -1.660640e-04
## ASV1171      6.593332e-05  6.846263e-05  7.106008e-05  7.372476e-05
## ASV1942      3.131037e-04  3.274846e-04  3.425022e-04  3.581823e-04
## ASV1889      3.100521e-05  3.232304e-05  3.368915e-05  3.510456e-05
## ASV0920      7.009310e-05  7.347801e-05  7.702738e-05  8.074916e-05
## ASV1805     -4.004745e-04 -4.186041e-04 -4.375113e-04 -4.572258e-04
## ASV1712      2.391479e-04  2.497528e-04  2.607910e-04  2.722770e-04
## ASV1458      3.506707e-04  3.660385e-04  3.820232e-04  3.986450e-04
## ASV1985      3.740521e-04  3.908499e-04  4.083573e-04  4.266005e-04
## ASV2960     -2.361339e-04 -2.459239e-04 -2.560591e-04 -2.665466e-04
## ASV5207     -6.998043e-05 -7.234285e-05 -7.473976e-05 -7.716733e-05
## ASV8548     -2.361086e-04 -2.458967e-04 -2.560296e-04 -2.665148e-04
## ASV0449     -1.447112e-04 -1.516133e-04 -1.588386e-04 -1.664012e-04
## ASV0609     -3.230630e-04 -3.374777e-04 -3.524901e-04 -3.681211e-04
## ASV1038      1.226701e-04  1.277226e-04  1.329471e-04  1.383460e-04
## ASV1145     -7.358650e-05 -7.650696e-05 -7.951708e-05 -8.261730e-05
## ASV15767    -2.361039e-04 -2.458917e-04 -2.560244e-04 -2.665093e-04
## ASV1630      3.350443e-04  3.495295e-04  3.645798e-04  3.802122e-04
## ASV1911      4.212079e-04  4.404006e-04  4.604279e-04  4.813225e-04
## ASV1950      3.015183e-04  3.143848e-04  3.277388e-04  3.415940e-04
## ASV2583      2.360305e-04  2.458120e-04  2.559380e-04  2.664156e-04
## ASV2853     -3.489765e-04 -3.641773e-04 -3.799802e-04 -3.964042e-04
## ASV2948      2.359868e-04  2.457645e-04  2.558864e-04  2.663596e-04
## ASV3116     -3.795283e-04 -3.958011e-04 -4.126953e-04 -4.302285e-04
## ASV3160     -2.023801e-04 -2.106035e-04 -2.191012e-04 -2.278776e-04
## ASV3354      2.534184e-04  2.650097e-04  2.771063e-04  2.897277e-04
## ASV3368      2.359269e-04  2.456997e-04  2.558162e-04  2.662836e-04
## ASV3464     -2.359061e-04 -2.456771e-04 -2.557917e-04 -2.662572e-04
## ASV3577      2.358853e-04  2.456546e-04  2.557673e-04  2.662307e-04
## ASV3746      3.099357e-04  3.231280e-04  3.368141e-04  3.510068e-04
## ASV3942      1.053099e-04  1.106460e-04  1.162609e-04  1.221695e-04
## ASV4000      2.358508e-04  2.456172e-04  2.557268e-04  2.661870e-04
## ASV4207      4.296336e-04  4.496558e-04  4.705885e-04  4.924711e-04
## ASV4261      2.358328e-04  2.455977e-04  2.557058e-04  2.661643e-04
## ASV4466      9.014751e-05  9.503282e-05  1.001948e-04  1.056491e-04
## ASV4487     -2.358192e-04 -2.455832e-04 -2.556903e-04 -2.661476e-04
## ASV4572     -1.791651e-04 -1.867791e-04 -1.946796e-04 -2.028743e-04
## ASV4718      2.357846e-04  2.455457e-04  2.556496e-04  2.661036e-04
## ASV4757     -2.357638e-04 -2.455231e-04 -2.556252e-04 -2.660771e-04
## ASV4929     -2.357430e-04 -2.455006e-04 -2.556008e-04 -2.660507e-04
## ASV5611     -2.357222e-04 -2.454781e-04 -2.555764e-04 -2.660243e-04
## ASV5614     -2.357014e-04 -2.454555e-04 -2.555520e-04 -2.659979e-04
## ASV5898      2.061029e-04  2.151701e-04  2.246022e-04  2.344108e-04
## ASV7627     -4.932983e-05 -5.078929e-05 -5.224735e-05 -5.369906e-05
## ASV3105     -1.288482e-04 -1.339631e-04 -1.392391e-04 -1.446779e-04
## ASV4762     -3.490908e-04 -3.643100e-04 -3.801334e-04 -3.965799e-04
## ASV5622      2.356487e-04  2.453984e-04  2.554902e-04  2.659311e-04
## ASV7129      3.100629e-04  3.238734e-04  3.382568e-04  3.532333e-04
## ASV12138    -2.356201e-04 -2.453674e-04 -2.554566e-04 -2.658947e-04
## ASV1687     -3.554118e-04 -3.712487e-04 -3.877475e-04 -4.049325e-04
## ASV2187      1.745499e-04  1.816802e-04  1.890527e-04  1.966719e-04
## ASV2204      3.594854e-04  3.753816e-04  3.919250e-04  4.091372e-04
## ASV2914      2.763962e-04  2.880397e-04  3.001106e-04  3.126196e-04
## ASV3297     -2.355441e-04 -2.452849e-04 -2.553671e-04 -2.657976e-04
## ASV3310     -3.038020e-04 -3.167458e-04 -3.301778e-04 -3.441112e-04
## ASV3677      2.083581e-05  2.259207e-05  2.449109e-05  2.654346e-05
## ASV4508      2.354996e-04  2.452368e-04  2.553150e-04  2.657414e-04
## ASV6236     -1.128422e-04 -1.170101e-04 -1.212789e-04 -1.256463e-04
## ASV6285      2.354706e-04  2.452055e-04  2.552812e-04  2.657049e-04
## ASV7576     -2.354499e-04 -2.451830e-04 -2.552568e-04 -2.656785e-04
## ASV7917     -2.354291e-04 -2.451605e-04 -2.552325e-04 -2.656522e-04
## ASV9353     -2.354084e-04 -2.451380e-04 -2.552082e-04 -2.656259e-04
## ASV1656      3.937098e-04  4.109986e-04  4.289828e-04  4.476849e-04
## ASV0280     -3.776486e-04 -3.952623e-04 -4.136796e-04 -4.329355e-04
## ASV4747      7.745846e-06  8.479633e-06  9.281249e-06  1.015674e-05
## ASV2108     -4.625809e-04 -4.839825e-04 -5.063456e-04 -5.297107e-04
## ASV0885      1.548618e-04  1.619516e-04  1.693530e-04  1.770786e-04
## ASV2538     -1.249321e-04 -1.303965e-04 -1.360777e-04 -1.419823e-04
## ASV0968      2.846013e-04  2.974175e-04  3.107767e-04  3.246991e-04
## ASV1229     -2.556522e-04 -2.671528e-04 -2.791391e-04 -2.916286e-04
## ASV13306    -2.556276e-04 -2.671259e-04 -2.791097e-04 -2.915966e-04
## ASV13952     1.549848e-04  1.615700e-04  1.683998e-04  1.754801e-04
## ASV14631     1.440302e-04  1.511327e-04  1.585951e-04  1.664362e-04
## ASV2119      2.997768e-04  3.125039e-04  3.257023e-04  3.393836e-04
## ASV2450      2.670165e-04  2.792469e-04  2.920153e-04  3.053435e-04
## ASV2656     -2.556180e-04 -2.671155e-04 -2.790985e-04 -2.915844e-04
## ASV2942     -1.838927e-05 -1.916764e-05 -1.997406e-05 -2.080906e-05
## ASV3302      2.275428e-04  2.376332e-04  2.481364e-04  2.590661e-04
## ASV6515      8.665002e-05  9.014296e-05  9.374820e-05  9.746687e-05
## ASV6674     -2.555978e-04 -2.670934e-04 -2.790743e-04 -2.915580e-04
## ASV7296     -9.516804e-05 -9.959390e-05 -1.042195e-04 -1.090533e-04
## ASV7903      1.394119e-04  1.453886e-04  1.515929e-04  1.580310e-04
## ASV7943     -2.555719e-04 -2.670651e-04 -2.790433e-04 -2.915241e-04
## ASV8864      1.852755e-04  1.927199e-04  2.004010e-04  2.083208e-04
## ASV9389      2.202633e-05  2.240700e-05  2.275053e-05  2.305107e-05
## ASV9869     -2.555544e-04 -2.670458e-04 -2.790221e-04 -2.915008e-04
## ASV1051      2.555297e-04  2.670189e-04  2.789928e-04  2.914688e-04
## ASV13035    -1.095948e-05 -1.135728e-05 -1.176302e-05 -1.217618e-05
## ASV15744     8.341298e-06  9.167162e-06  1.007072e-05  1.105894e-05
## ASV2526      2.615384e-05  2.706633e-05  2.799476e-05  2.893786e-05
## ASV1156      1.334652e-04  1.393812e-04  1.455398e-04  1.519493e-04
## ASV13562    -2.555158e-04 -2.670038e-04 -2.789763e-04 -2.914508e-04
## ASV1438      2.246167e-04  2.350547e-04  2.459665e-04  2.573730e-04
## ASV2268     -2.555033e-04 -2.669901e-04 -2.789614e-04 -2.914347e-04
## ASV2797      1.238479e-04  1.297579e-04  1.359497e-04  1.424370e-04
## ASV3744      2.857347e-04  2.988669e-04  3.125790e-04  3.268942e-04
## ASV8076     -2.753872e-04 -2.877921e-04 -3.007224e-04 -3.141972e-04
## ASV7055      1.197548e-04  1.256307e-04  1.318010e-04  1.382809e-04
## ASV7493     -2.336449e-04 -2.442474e-04 -2.553067e-04 -2.668402e-04
## ASV1201      5.675881e-04  5.930440e-04  6.195699e-04  6.472046e-04
## ASV5736     -4.926234e-04 -5.151891e-04 -5.387459e-04 -5.633334e-04
## ASV0558      2.390475e-04  2.502030e-04  2.618662e-04  2.740590e-04
## ASV14399    -3.402090e-04 -3.554387e-04 -3.713064e-04 -3.878352e-04
## ASV2992     -1.917965e-05 -2.001906e-05 -2.089177e-05 -2.179879e-05
## ASV4303     -2.500659e-04 -2.613039e-04 -2.730155e-04 -2.852178e-04
## ASV0565     -2.852197e-04 -2.981799e-04 -3.117018e-04 -3.258076e-04
## ASV0977     -4.213538e-04 -4.394134e-04 -4.581624e-04 -4.776205e-04
## ASV0140      2.137544e-04  2.233584e-04  2.333675e-04  2.437964e-04
## ASV14421    -2.566836e-04 -2.682869e-04 -2.803861e-04 -2.929999e-04
## ASV16909    -5.759425e-05 -6.034334e-05 -6.322313e-05 -6.623971e-05
## ASV3762     -2.566540e-04 -2.682545e-04 -2.803507e-04 -2.929612e-04
## ASV7141     -2.566291e-04 -2.682273e-04 -2.803210e-04 -2.929288e-04
## ASV3291      4.091024e-04  4.279832e-04  4.477069e-04  4.683085e-04
## ASV10440    -2.566002e-04 -2.681958e-04 -2.802866e-04 -2.928912e-04
## ASV10802     7.809140e-05  8.155480e-05  8.516009e-05  8.891206e-05
## ASV1698      4.335315e-05  4.547198e-05  4.769638e-05  5.003174e-05
## ASV2121      2.565819e-04  2.681758e-04  2.802647e-04  2.928673e-04
## ASV3549     -3.625273e-04 -3.789684e-04 -3.961165e-04 -4.139987e-04
## ASV6379      3.018379e-04  3.150891e-04  3.288720e-04  3.432039e-04
## ASV6824     -2.565271e-04 -2.681159e-04 -2.801994e-04 -2.927960e-04
## ASV8254      2.709980e-05  2.845700e-05  2.988431e-05  3.138546e-05
## ASV9951      1.136728e-04  1.190428e-04  1.246639e-04  1.305473e-04
## ASV1515     -1.065816e-04 -1.111416e-04 -1.158723e-04 -1.207778e-04
## ASV4327      7.831316e-05  8.186580e-05  8.557177e-05  8.943700e-05
## ASV0341     -1.198833e-04 -1.255508e-04 -1.314831e-04 -1.376922e-04
## ASV5562     -2.105690e-04 -2.204219e-04 -2.307274e-04 -2.415057e-04
## ASV1412      5.752128e-04  6.014109e-04  6.287483e-04  6.572697e-04
## ASV0154     -4.636238e-04 -4.849873e-04 -5.073020e-04 -5.306075e-04
## ASV3163     -2.137022e-04 -2.232764e-04 -2.332533e-04 -2.436476e-04
## ASV1782     -3.411394e-04 -3.566045e-04 -3.727332e-04 -3.895505e-04
## ASV3993     -3.623983e-05 -3.765246e-05 -3.910494e-05 -4.059692e-05
## ASV3164      1.632302e-04  1.703497e-04  1.777491e-04  1.854369e-04
## ASV1024      2.148979e-05  2.266383e-05  2.390741e-05  2.522501e-05
## ASV0771     -4.646833e-04 -4.852054e-04 -5.065606e-04 -5.287764e-04
## ASV2223     -2.079636e-04 -2.178448e-04 -2.281900e-04 -2.390200e-04
## ASV1638      7.703513e-04  8.048833e-04  8.408656e-04  8.783503e-04
## ASV0232     -2.262666e-04 -2.364565e-04 -2.470788e-04 -2.581494e-04
## ASV6771     -2.519274e-04 -2.636946e-04 -2.759976e-04 -2.888595e-04
## ASV4243     -9.760081e-05 -1.017040e-04 -1.059590e-04 -1.103701e-04
## ASV0162     -4.624674e-04 -4.834291e-04 -5.052894e-04 -5.280818e-04
## ASV0049      3.203608e-05  3.351563e-05  3.506164e-05  3.667696e-05
## ASV4697     -2.579658e-04 -2.696864e-04 -2.819132e-04 -2.946658e-04
## ASV12326     8.138911e-05  8.482693e-05  8.838983e-05  9.208058e-05
## ASV12586    -2.579445e-04 -2.696631e-04 -2.818877e-04 -2.946379e-04
## ASV1879      2.042875e-04  2.135883e-04  2.232920e-04  2.334140e-04
## ASV2864      5.640127e-04  5.899447e-04  6.170256e-04  6.453022e-04
## ASV3111     -1.499040e-04 -1.566840e-04 -1.637541e-04 -1.711253e-04
## ASV5633     -1.436790e-04 -1.501300e-04 -1.568527e-04 -1.638570e-04
## ASV5864      8.548294e-05  8.878505e-05  9.217834e-05  9.566190e-05
## ASV6364      1.249017e-04  1.308392e-04  1.370579e-04  1.435708e-04
## ASV1598      1.594048e-04  1.666930e-04  1.743020e-04  1.822452e-04
## ASV2649     -9.597704e-05 -1.006847e-04 -1.056272e-04 -1.108164e-04
## ASV4664      2.114672e-04  2.208126e-04  2.305393e-04  2.406602e-04
## ASV2654      3.573816e-04  3.735256e-04  3.903580e-04  4.079045e-04
## ASV6636     -2.621449e-05 -2.780803e-05 -2.950489e-05 -3.131183e-05
## ASV3334      2.680302e-04  2.806620e-04  2.938807e-04  3.077128e-04
## ASV0046     -4.772492e-04 -4.996021e-04 -5.229823e-04 -5.474349e-04
## ASV0661      4.792273e-04  5.005395e-04  5.227323e-04  5.458362e-04
## ASV0774      2.159240e-04  2.257612e-04  2.360252e-04  2.467322e-04
## ASV3815      2.572973e-04  2.688071e-04  2.807973e-04  2.932848e-04
## ASV0575      2.581286e-04  2.693461e-04  2.810039e-04  2.931154e-04
## ASV1953     -3.590429e-04 -3.753336e-04 -3.923249e-04 -4.100436e-04
## ASV0610      1.076134e-04  1.123188e-04  1.172115e-04  1.222977e-04
## ASV0245     -1.313263e-04 -1.373367e-04 -1.436108e-04 -1.501592e-04
## ASV3805     -1.864152e-04 -1.938879e-04 -2.016006e-04 -2.095562e-04
## ASV1182      5.380263e-04  5.630517e-04  5.892126e-04  6.165580e-04
## ASV1941      1.518214e-06  1.662283e-06  1.819782e-06  1.991921e-06
## ASV0080     -6.300470e-04 -6.585085e-04 -6.881841e-04 -7.191190e-04
## ASV1033      1.883631e-04  1.969271e-04  2.058616e-04  2.151810e-04
## ASV5330     -2.259189e-04 -2.360418e-04 -2.465887e-04 -2.575747e-04
## ASV9702     -3.433514e-04 -3.580314e-04 -3.732687e-04 -3.890785e-04
## ASV0358      8.580469e-06  8.759025e-06  8.925899e-06  9.078875e-06
## ASV2225      1.786878e-04  1.867091e-04  1.950678e-04  2.037759e-04
## ASV2606      7.529809e-06  7.673353e-06  7.804376e-06  7.920623e-06
## ASV3510     -2.787981e-04 -2.914576e-04 -3.046632e-04 -3.184360e-04
## ASV3069      9.416792e-05  9.804833e-05  1.020629e-04  1.062142e-04
## ASV3849      1.722945e-04  1.798512e-04  1.877095e-04  1.958787e-04
## ASV1810     -4.328826e-04 -4.516112e-04 -4.710704e-04 -4.912821e-04
## ASV2046      6.407801e-04  6.701158e-04  7.007386e-04  7.326999e-04
## ASV2451     -7.897923e-05 -8.300086e-05 -8.723420e-05 -9.169061e-05
## ASV4047      3.339036e-04  3.489459e-04  3.646272e-04  3.809712e-04
## ASV7402     -2.650929e-04 -2.774534e-04 -2.903750e-04 -3.038816e-04
## ASV8250      3.250904e-04  3.401493e-04  3.558856e-04  3.723275e-04
## ASV3468      2.780382e-04  2.905526e-04  3.035971e-04  3.171912e-04
## ASV3521      5.728469e-04  5.989750e-04  6.262419e-04  6.546925e-04
## ASV6363     -1.955562e-04 -2.047719e-04 -2.144145e-04 -2.245026e-04
## ASV6444      1.308218e-04  1.369994e-04  1.434672e-04  1.502388e-04
## ASV8231      1.499633e-04  1.566239e-04  1.635592e-04  1.707787e-04
## ASV0196     -8.571210e-04 -8.957909e-04 -9.361071e-04 -9.781310e-04
## ASV12801    -2.651056e-04 -2.774671e-04 -2.903899e-04 -3.038977e-04
## ASV12906    -2.650791e-04 -2.774381e-04 -2.903581e-04 -3.038629e-04
## ASV13040    -2.650526e-04 -2.774091e-04 -2.903263e-04 -3.038281e-04
## ASV1313     -2.798757e-05 -2.961885e-05 -3.135275e-05 -3.319604e-05
## ASV14008     7.544638e-05  7.916768e-05  8.307932e-05  8.719170e-05
## ASV1546      1.005179e-04  1.046697e-04  1.089640e-04  1.134032e-04
## ASV1637      4.955470e-04  5.179877e-04  5.413901e-04  5.657905e-04
## ASV17076     2.142471e-04  2.236576e-04  2.334453e-04  2.436221e-04
## ASV2061      7.356503e-04  7.683951e-04  8.024943e-04  8.379948e-04
## ASV2177      3.064369e-04  3.208746e-04  3.359838e-04  3.517945e-04
## ASV2943      4.485539e-04  4.687187e-04  4.897340e-04  5.116307e-04
## ASV3020      3.949254e-04  4.125346e-04  4.308742e-04  4.499694e-04
## ASV30254     1.815349e-05  1.857946e-05  1.898936e-05  1.937972e-05
## ASV3219      5.543085e-04  5.790811e-04  6.048873e-04  6.317639e-04
## ASV3352      4.858263e-04  5.080546e-04  5.312582e-04  5.554760e-04
## ASV3355      2.090376e-04  2.187840e-04  2.289723e-04  2.396211e-04
## ASV3377      3.773152e-04  3.945515e-04  4.125421e-04  4.313171e-04
## ASV3449      2.181784e-04  2.276720e-04  2.375383e-04  2.477885e-04
## ASV3893      2.650237e-04  2.773772e-04  2.902912e-04  3.037893e-04
## ASV4326      1.535336e-04  1.600818e-04  1.668750e-04  1.739194e-04
## ASV5016     -2.650049e-04 -2.773566e-04 -2.902685e-04 -3.037645e-04
## ASV5152      2.030544e-04  2.115184e-04  2.202811e-04  2.293482e-04
## ASV5666     -1.091679e-05 -1.165153e-05 -1.243822e-05 -1.328046e-05
## ASV5802     -2.714354e-04 -2.840633e-04 -2.972620e-04 -3.110555e-04
## ASV6070      1.866327e-04  1.947462e-04  2.031774e-04  2.119359e-04
## ASV6488      1.627017e-04  1.699807e-04  1.775640e-04  1.854626e-04
## ASV6562     -2.649613e-04 -2.773087e-04 -2.902159e-04 -3.037068e-04
## ASV6930      1.915797e-04  1.999212e-04  2.085906e-04  2.175977e-04
## ASV7243      3.478394e-04  3.632886e-04  3.793733e-04  3.961153e-04
## ASV7506      2.207289e-04  2.304189e-04  2.404971e-04  2.509759e-04
## ASV7553     -2.649416e-04 -2.772871e-04 -2.901922e-04 -3.036808e-04
## ASV8064      1.499991e-04  1.565921e-04  1.634494e-04  1.705792e-04
## ASV8434     -1.477756e-04 -1.548202e-04 -1.621977e-04 -1.699232e-04
## ASV8858     -2.649092e-04 -2.772515e-04 -2.901533e-04 -3.036380e-04
## ASV2600      1.524453e-04  1.595445e-04  1.669647e-04  1.747193e-04
## ASV3398      5.721235e-04  5.983099e-04  6.256461e-04  6.541780e-04
## ASV4584     -2.648705e-04 -2.772092e-04 -2.901068e-04 -3.035872e-04
## ASV4864      2.889587e-04  3.020246e-04  3.156495e-04  3.298546e-04
## ASV0082     -1.128830e-03 -1.180001e-03 -1.233373e-03 -1.289031e-03
## ASV9626      2.333580e-04  2.439971e-04  2.550985e-04  2.666803e-04
## ASV1617      1.003096e-04  1.043544e-04  1.085290e-04  1.128347e-04
## ASV2765     -6.123692e-05 -6.431190e-05 -6.754504e-05 -7.094452e-05
## ASV2167     -3.504904e-04 -3.663481e-04 -3.828847e-04 -4.001259e-04
## ASV1628      2.196023e-04  2.287954e-04  2.383184e-04  2.481782e-04
## ASV3260     -5.490755e-05 -5.719211e-05 -5.955610e-05 -6.200086e-05
## ASV3645      3.352510e-05  3.533254e-05  3.724050e-05  3.925443e-05
## ASV6057     -3.344809e-04 -3.496226e-04 -3.654135e-04 -3.818785e-04
## ASV0662     -4.408243e-05 -4.590304e-05 -4.778622e-05 -4.973299e-05
## ASV4267     -4.320762e-05 -4.529659e-05 -4.748605e-05 -4.978063e-05
## ASV1070      3.590135e-04  3.757662e-04  3.932841e-04  4.116007e-04
## ASV0633     -9.197873e-05 -9.596642e-05 -1.001093e-04 -1.044120e-04
## ASV0333      3.675170e-04  3.843837e-04  4.019958e-04  4.203838e-04
## ASV0966      2.792541e-04  2.920193e-04  3.053421e-04  3.192443e-04
## ASV1848      4.041248e-04  4.230635e-04  4.428741e-04  4.635951e-04
## ASV13390    -2.559599e-04 -2.674956e-04 -2.795210e-04 -2.920542e-04
## ASV14901    -2.559352e-04 -2.674686e-04 -2.794915e-04 -2.920220e-04
## ASV1676     -2.930679e-04 -3.059076e-04 -3.192593e-04 -3.331389e-04
## ASV1756     -3.083764e-05 -3.221028e-05 -3.363942e-05 -3.512696e-05
## ASV22537    -3.503912e-05 -3.650019e-05 -3.801276e-05 -3.957782e-05
## ASV3303     -4.589853e-06 -4.908269e-06 -5.249523e-06 -5.615191e-06
## ASV4030     -1.065605e-04 -1.112604e-04 -1.161504e-04 -1.212367e-04
## ASV4871      2.052992e-04  2.147570e-04  2.246358e-04  2.349530e-04
## ASV5536      1.267409e-05  1.325083e-05  1.385301e-05  1.448170e-05
## ASV5700      9.169504e-05  9.585031e-05  1.001836e-04  1.047014e-04
## ASV8957      1.674471e-04  1.742884e-04  1.813582e-04  1.886599e-04
## ASV11210     1.654656e-04  1.734944e-04  1.819177e-04  1.907551e-04
## ASV7585     -2.559258e-04 -2.674583e-04 -2.794803e-04 -2.920098e-04
## ASV8596     -2.559011e-04 -2.674313e-04 -2.794508e-04 -2.919777e-04
## ASV9532     -1.023057e-04 -1.067790e-04 -1.114296e-04 -1.162628e-04
## ASV4254      1.860008e-04  1.945922e-04  2.035675e-04  2.129427e-04
## ASV13299    -2.558793e-04 -2.674076e-04 -2.794250e-04 -2.919495e-04
## ASV15627    -2.558545e-04 -2.673806e-04 -2.793955e-04 -2.919173e-04
## ASV6302     -2.006956e-04 -2.088733e-04 -2.173265e-04 -2.260599e-04
## ASV3040      1.031333e-04  1.078362e-04  1.127436e-04  1.178634e-04
## ASV0632      2.101951e-04  2.198358e-04  2.299020e-04  2.404112e-04
## ASV3694      3.337731e-04  3.489190e-04  3.647173e-04  3.811929e-04
## ASV1592     -6.117554e-05 -6.357211e-05 -6.603914e-05 -6.857662e-05
## ASV0538      1.710152e-04  1.790400e-04  1.874366e-04  1.962220e-04
## ASV0832      3.726333e-04  3.894834e-04  4.070546e-04  4.253744e-04
## ASV0727      2.830002e-04  2.962473e-04  3.101031e-04  3.245947e-04
## ASV1165     -3.622702e-04 -3.788421e-04 -3.961409e-04 -4.141956e-04
## ASV1325      4.316435e-05  4.597705e-05  4.899032e-05  5.221924e-05
## ASV0819      6.499429e-04  6.796299e-04  7.106155e-04  7.429511e-04
## ASV2251      3.435512e-04  3.578512e-04  3.726532e-04  3.879664e-04
## ASV0100     -2.214019e-05 -2.309987e-05 -2.409642e-05 -2.513080e-05
## ASV0444     -1.733124e-04 -1.812431e-04 -1.895237e-04 -1.981686e-04
## ASV0800      8.448857e-04  8.822263e-04  9.210896e-04  9.615266e-04
## ASV2432      1.817628e-05  1.866547e-05  1.914802e-05  1.962160e-05
## ASV2883      2.295051e-05  2.376358e-05  2.459064e-05  2.543032e-05
## ASV3894      2.566288e-05  2.643186e-05  2.719800e-05  2.795798e-05
## ASV2367      5.928798e-04  6.196506e-04  6.475638e-04  6.766624e-04
## ASV3724     -3.520582e-04 -3.678132e-04 -3.842273e-04 -4.013241e-04
## ASV2112     -3.014945e-04 -3.152774e-04 -3.296627e-04 -3.446740e-04
## ASV3661      1.047649e-04  1.096768e-04  1.148152e-04  1.201904e-04
## ASV2096     -2.193464e-04 -2.296792e-04 -2.404891e-04 -2.517969e-04
## ASV3551     -2.513213e-04 -2.623821e-04 -2.738873e-04 -2.858510e-04
## ASV11343    -9.067870e-06 -9.633068e-06 -1.023703e-05 -1.088261e-05
## ASV2051      2.170159e-04  2.270482e-04  2.375326e-04  2.484886e-04
## ASV2617     -2.970136e-04 -3.104230e-04 -3.244040e-04 -3.389779e-04
## ASV0125     -1.317454e-04 -1.377716e-04 -1.440609e-04 -1.506234e-04
## ASV0372      4.526727e-04  4.731112e-04  4.944211e-04  5.166352e-04
## ASV6751     -3.376086e-04 -3.526616e-04 -3.683398e-04 -3.846650e-04
## ASV10810     7.586117e-05  7.932568e-05  8.294276e-05  8.671874e-05
## ASV0461     -1.938890e-04 -2.028692e-04 -2.122531e-04 -2.220578e-04
## ASV1945     -1.153179e-04 -1.207527e-04 -1.264403e-04 -1.323920e-04
## ASV0882     -9.993671e-05 -1.050277e-04 -1.103882e-04 -1.160330e-04
## ASV4040     -4.926415e-05 -5.149776e-05 -5.382570e-05 -5.625119e-05
## ASV0109     -3.224399e-06 -3.330517e-06 -3.437197e-06 -3.544053e-06
## ASV0174      1.499337e-04  1.560827e-04  1.624366e-04  1.689979e-04
## ASV2851      2.584021e-04  2.695283e-04  2.810794e-04  2.930668e-04
## ASV5312      4.397236e-05  4.595197e-05  4.801837e-05  5.017540e-05
## ASV9402     -3.621682e-04 -3.783977e-04 -3.953079e-04 -4.129231e-04
## ASV4870     -2.922580e-04 -3.052578e-04 -3.187944e-04 -3.328865e-04
## ASV0589      3.503678e-04  3.662475e-04  3.828099e-04  4.000811e-04
## ASV1221      9.624247e-07  1.046903e-06  1.138360e-06  1.237314e-06
## ASV6028     -3.388239e-04 -3.541270e-04 -3.700840e-04 -3.867195e-04
## ASV5106     -1.268265e-04 -1.323570e-04 -1.381059e-04 -1.440796e-04
## ASV4977     -4.776270e-05 -5.043468e-05 -5.326637e-05 -5.626770e-05
## ASV5715     -2.226717e-04 -2.327474e-04 -2.432552e-04 -2.542114e-04
## ASV4182      8.545715e-05  8.973295e-05  9.423056e-05  9.896203e-05
## ASV2383     -2.001227e-05 -2.138755e-05 -2.286620e-05 -2.445635e-05
## ASV3985      4.016256e-04  4.202858e-04  4.397909e-04  4.601770e-04
## ASV2787     -2.989122e-04 -3.119871e-04 -3.255837e-04 -3.397185e-04
## ASV6756     -2.592480e-04 -2.711525e-04 -2.835820e-04 -2.965574e-04
## ASV1634     -4.125136e-04 -4.307960e-04 -4.498272e-04 -4.696324e-04
## ASV0649     -1.269590e-04 -1.327660e-04 -1.388264e-04 -1.451501e-04
## ASV1591     -9.351732e-06 -1.018706e-05 -1.109353e-05 -1.207674e-05
## ASV1854      4.317255e-04  4.518566e-04  4.729045e-04  4.949088e-04
## ASV4205      2.878934e-04  3.013204e-04  3.153596e-04  3.300376e-04
## ASV3293     -1.649379e-04 -1.722322e-04 -1.798240e-04 -1.877235e-04
## ASV1631      1.947797e-04  2.036351e-04  2.128749e-04  2.225141e-04
## ASV1747     -1.118293e-04 -1.172098e-04 -1.228501e-04 -1.287625e-04
## ASV5634      8.818336e-05  9.217621e-05  9.634120e-05  1.006850e-04
## ASV0965     -1.386093e-04 -1.448173e-04 -1.512860e-04 -1.580248e-04
## ASV1094      2.392250e-04  2.499497e-04  2.611258e-04  2.727697e-04
## ASV2744     -9.525282e-06 -1.037553e-05 -1.129810e-05 -1.229869e-05
## ASV7212     -3.643703e-04 -3.812183e-04 -3.988191e-04 -4.172035e-04
## ASV0344     -2.407138e-04 -2.516488e-04 -2.630564e-04 -2.749549e-04
## ASV11812    -2.611993e-04 -2.732099e-04 -2.857516e-04 -2.988457e-04
## ASV7867     -3.832778e-05 -4.021177e-05 -4.218924e-05 -4.426476e-05
## ASV6670      2.347091e-04  2.448252e-04  2.553317e-04  2.662401e-04
## ASV10991     2.145329e-06  1.609836e-06  9.957359e-07  2.953306e-07
## ASV1281      4.685750e-04  4.906133e-04  5.136726e-04  5.377987e-04
## ASV12845    -2.611768e-04 -2.731852e-04 -2.857245e-04 -2.988160e-04
## ASV1833     -2.611511e-04 -2.731571e-04 -2.856937e-04 -2.987823e-04
## ASV2211      1.678816e-04  1.750961e-04  1.825861e-04  1.903592e-04
## ASV3920      3.654747e-04  3.816359e-04  3.984546e-04  4.159527e-04
## ASV4545     -2.968215e-04 -3.104960e-04 -3.247775e-04 -3.396910e-04
## ASV4710     -3.239378e-04 -3.388175e-04 -3.543540e-04 -3.705735e-04
## ASV4978      5.169439e-05  5.409381e-05  5.660166e-05  5.922255e-05
## ASV9630     -9.198164e-06 -9.653631e-06 -1.013196e-05 -1.063430e-05
## ASV9797     -1.058492e-05 -1.145366e-05 -1.239447e-05 -1.341311e-05
## ASV13469    -2.610819e-04 -2.730812e-04 -2.856106e-04 -2.986913e-04
## ASV14961    -9.522973e-05 -9.959078e-05 -1.041428e-04 -1.088934e-04
## ASV6259      1.454030e-04  1.517540e-04  1.583563e-04  1.652174e-04
## ASV6294     -1.859204e-04 -1.944720e-04 -2.034016e-04 -2.127246e-04
## ASV6883     -8.765444e-05 -9.182767e-05 -9.619779e-05 -1.007738e-04
## ASV7041     -2.166048e-04 -2.267882e-04 -2.374412e-04 -2.485842e-04
## ASV4363     -2.514902e-04 -2.626243e-04 -2.742138e-04 -2.862739e-04
## ASV1784     -3.680746e-04 -3.847732e-04 -4.021914e-04 -4.203568e-04
## ASV2140      3.303247e-05  3.459770e-05  3.623513e-05  3.794778e-05
## ASV3202      2.514513e-04  2.625819e-04  2.741675e-04  2.862234e-04
## ASV6017     -2.514274e-04 -2.625559e-04 -2.741391e-04 -2.861925e-04
## ASV9129      1.259962e-04  1.314564e-04  1.371283e-04  1.430177e-04
## ASV0917      2.579768e-04  2.694151e-04  2.813228e-04  2.937159e-04
## ASV10584    -2.393394e-06 -2.160865e-06 -1.889029e-06 -1.573991e-06
## ASV11218     1.631491e-04  1.702483e-04  1.776255e-04  1.852890e-04
## ASV11229     2.525984e-05  2.674209e-05  2.831698e-05  2.999040e-05
## ASV11604    -2.956758e-05 -3.106772e-05 -3.264652e-05 -3.430818e-05
## ASV2103     -2.958767e-04 -3.091300e-04 -3.229400e-04 -3.373267e-04
## ASV2165     -2.513604e-04 -2.624828e-04 -2.740595e-04 -2.861057e-04
## ASV2340      2.774320e-04  2.892735e-04  3.015592e-04  3.143007e-04
## ASV3738     -2.513326e-04 -2.624524e-04 -2.740264e-04 -2.860697e-04
## ASV4012      7.626891e-05  7.963528e-05  8.313779e-05  8.678083e-05
## ASV4094     -2.513126e-04 -2.624307e-04 -2.740027e-04 -2.860439e-04
## ASV4454     -2.512888e-04 -2.624047e-04 -2.739744e-04 -2.860130e-04
## ASV7031      6.049303e-05  6.343821e-05  6.652830e-05  6.977041e-05
## ASV7087     -9.508496e-05 -9.905241e-05 -1.031608e-04 -1.074130e-04
## ASV4159      1.453120e-05  1.510926e-05  1.570464e-05  1.631731e-05
## ASV5084     -2.512621e-04 -2.623757e-04 -2.739428e-04 -2.859788e-04
## ASV6584     -2.512383e-04 -2.623497e-04 -2.739145e-04 -2.859479e-04
## ASV9614     -2.512145e-04 -2.623238e-04 -2.738862e-04 -2.859171e-04
## ASV16068    -2.511907e-04 -2.622978e-04 -2.738580e-04 -2.858863e-04
## ASV2141     -3.318917e-04 -3.460259e-04 -3.606922e-04 -3.759052e-04
## ASV0395     -2.407804e-05 -2.525499e-05 -2.649091e-05 -2.778888e-05
## ASV5640     -5.948351e-05 -6.235120e-05 -6.535683e-05 -6.850686e-05
## ASV2854     -2.821065e-04 -2.944823e-04 -3.073546e-04 -3.207396e-04
## ASV3825     -4.995994e-04 -5.221379e-04 -5.456368e-04 -5.701322e-04
## ASV0481      5.414905e-04  5.651775e-04  5.898104e-04  6.154194e-04
## ASV3304      2.564351e-05  2.685924e-05  2.813254e-05  2.946613e-05
## ASV0445      3.307886e-04  3.455668e-04  3.609611e-04  3.769933e-04
## ASV1845     -1.751683e-04 -1.833374e-04 -1.918782e-04 -2.008064e-04
## ASV3110     -1.916778e-04 -2.002521e-04 -2.091883e-04 -2.185004e-04

Stats::glm - Client needs p-values for each bacteria

3226

R documentation: https://www.rdocumentation.org/packages/stats/versions/3.6.2/topics/glm

278 x 3226 ASVs

library(stats)

logreg <- stats::glm(as.factor(Clade) ~ . ,
                     data = lr_clr_df[,-1],
                     family = "binomial")
summary(logreg)
## 
## Call:
## stats::glm(formula = as.factor(Clade) ~ ., family = "binomial", 
##     data = lr_clr_df[, -1])
## 
## Coefficients: (2949 not defined because of singularities)
##               Estimate Std. Error    z value Pr(>|z|)    
## (Intercept) -2.880e+31  4.028e+22 -7.149e+08   <2e-16 ***
## ASV1236     -4.149e+34  1.535e+38  0.000e+00    1.000    
## ASV0421     -7.219e+33  1.502e+37  0.000e+00    1.000    
## ASV0691     -1.816e+35  4.601e+38  0.000e+00    1.000    
## ASV0899      2.866e+34  6.424e+37  0.000e+00    1.000    
## ASV1004      8.578e+32  1.052e+37  0.000e+00    1.000    
## ASV1041      3.840e+34  6.224e+37  1.000e-03    1.000    
## ASV1058      6.163e+34  1.644e+38  0.000e+00    1.000    
## ASV12542    -9.556e+34  1.808e+38 -1.000e-03    1.000    
## ASV1294      5.553e+34  1.377e+38  0.000e+00    1.000    
## ASV13113     1.161e+33  4.798e+36  0.000e+00    1.000    
## ASV1318      1.158e+34  1.613e+37  1.000e-03    0.999    
## ASV2269      1.568e+35  3.485e+38  0.000e+00    1.000    
## ASV2542     -8.830e+32  1.637e+36 -1.000e-03    1.000    
## ASV2660     -1.285e+35  3.058e+38  0.000e+00    1.000    
## ASV2737     -5.775e+34  1.922e+38  0.000e+00    1.000    
## ASV2840      1.919e+33  6.876e+36  0.000e+00    1.000    
## ASV3053      1.422e+34  2.018e+38  0.000e+00    1.000    
## ASV3077     -1.166e+35  3.957e+38  0.000e+00    1.000    
## ASV3134     -8.330e+31  3.634e+36  0.000e+00    1.000    
## ASV3140     -1.154e+34  1.880e+37 -1.000e-03    1.000    
## ASV3579     -6.390e+33  1.505e+37  0.000e+00    1.000    
## ASV6119             NA         NA         NA       NA    
## ASV7557             NA         NA         NA       NA    
## ASV8422             NA         NA         NA       NA    
## ASV1086             NA         NA         NA       NA    
## ASV1310      2.802e+34  3.158e+37  1.000e-03    0.999    
## ASV15750     1.307e+35  3.444e+38  0.000e+00    1.000    
## ASV16905            NA         NA         NA       NA    
## ASV2033     -1.608e+34  1.242e+37 -1.000e-03    0.999    
## ASV2089             NA         NA         NA       NA    
## ASV2127     -1.090e+34  4.184e+37  0.000e+00    1.000    
## ASV2725      2.892e+34  8.052e+37  0.000e+00    1.000    
## ASV2804             NA         NA         NA       NA    
## ASV3075      1.043e+34  2.681e+37  0.000e+00    1.000    
## ASV3327      2.417e+34  9.291e+37  0.000e+00    1.000    
## ASV3342     -9.806e+33  3.121e+37  0.000e+00    1.000    
## ASV3532     -1.473e+34  3.186e+37  0.000e+00    1.000    
## ASV3600     -7.428e+33  1.552e+37  0.000e+00    1.000    
## ASV4013      2.677e+34  2.153e+37  1.000e-03    0.999    
## ASV4136     -2.299e+34  8.747e+37  0.000e+00    1.000    
## ASV4195             NA         NA         NA       NA    
## ASV4407             NA         NA         NA       NA    
## ASV4717             NA         NA         NA       NA    
## ASV6794             NA         NA         NA       NA    
## ASV8324             NA         NA         NA       NA    
## ASV8981     -4.567e+33  1.680e+37  0.000e+00    1.000    
## ASV9859     -2.192e+33  2.132e+37  0.000e+00    1.000    
## ASV0936      1.234e+34  1.426e+37  1.000e-03    0.999    
## ASV12683            NA         NA         NA       NA    
## ASV1293      1.416e+34  3.309e+37  0.000e+00    1.000    
## ASV13055            NA         NA         NA       NA    
## ASV17063            NA         NA         NA       NA    
## ASV2228             NA         NA         NA       NA    
## ASV2769     -7.899e+34  1.269e+38 -1.000e-03    1.000    
## ASV2803     -8.155e+33  8.833e+37  0.000e+00    1.000    
## ASV2896     -1.485e+33  2.748e+36 -1.000e-03    1.000    
## ASV3062             NA         NA         NA       NA    
## ASV3107     -4.028e+31  1.982e+36  0.000e+00    1.000    
## ASV3265     -5.383e+31  2.193e+37  0.000e+00    1.000    
## ASV3666             NA         NA         NA       NA    
## ASV4497      9.538e+34  2.124e+38  0.000e+00    1.000    
## ASV6914             NA         NA         NA       NA    
## ASV0576      1.539e+35  3.360e+38  0.000e+00    1.000    
## ASV0673     -6.677e+34  1.355e+38  0.000e+00    1.000    
## ASV0772     -6.733e+34  7.108e+37 -1.000e-03    0.999    
## ASV0862             NA         NA         NA       NA    
## ASV0898             NA         NA         NA       NA    
## ASV0910     -4.105e+33  4.223e+36 -1.000e-03    0.999    
## ASV0964             NA         NA         NA       NA    
## ASV10059    -9.224e+32  5.249e+35 -2.000e-03    0.999    
## ASV10263            NA         NA         NA       NA    
## ASV1088     -9.203e+33  9.383e+36 -1.000e-03    0.999    
## ASV1101             NA         NA         NA       NA    
## ASV1183      8.080e+33  2.922e+37  0.000e+00    1.000    
## ASV11956            NA         NA         NA       NA    
## ASV12774            NA         NA         NA       NA    
## ASV1321             NA         NA         NA       NA    
## ASV13793            NA         NA         NA       NA    
## ASV14482            NA         NA         NA       NA    
## ASV15483            NA         NA         NA       NA    
## ASV2062             NA         NA         NA       NA    
## ASV2132      2.636e+33  7.287e+36  0.000e+00    1.000    
## ASV2413             NA         NA         NA       NA    
## ASV2490             NA         NA         NA       NA    
## ASV2594     -3.671e+33  3.510e+36 -1.000e-03    0.999    
## ASV2822             NA         NA         NA       NA    
## ASV2863             NA         NA         NA       NA    
## ASV2910             NA         NA         NA       NA    
## ASV2980     -1.018e+34  1.300e+37 -1.000e-03    0.999    
## ASV3307             NA         NA         NA       NA    
## ASV3474             NA         NA         NA       NA    
## ASV3502      1.174e+33  3.275e+37  0.000e+00    1.000    
## ASV4236             NA         NA         NA       NA    
## ASV4842             NA         NA         NA       NA    
## ASV4894             NA         NA         NA       NA    
## ASV5290             NA         NA         NA       NA    
## ASV5501      6.076e+33  5.417e+37  0.000e+00    1.000    
## ASV5795             NA         NA         NA       NA    
## ASV5987             NA         NA         NA       NA    
## ASV6267             NA         NA         NA       NA    
## ASV6862             NA         NA         NA       NA    
## ASV7145             NA         NA         NA       NA    
## ASV7673             NA         NA         NA       NA    
## ASV7789             NA         NA         NA       NA    
## ASV7809             NA         NA         NA       NA    
## ASV8002             NA         NA         NA       NA    
## ASV8205      1.721e+33  1.992e+36  1.000e-03    0.999    
## ASV9155             NA         NA         NA       NA    
## ASV9221     -4.034e+33  1.323e+37  0.000e+00    1.000    
## ASV9311             NA         NA         NA       NA    
## ASV9557             NA         NA         NA       NA    
## ASV9936             NA         NA         NA       NA    
## ASV1445      3.537e+33  1.047e+37  0.000e+00    1.000    
## ASV4232      2.474e+32  5.699e+36  0.000e+00    1.000    
## ASV6479     -3.591e+33  1.755e+37  0.000e+00    1.000    
## ASV0142     -6.407e+34  8.205e+37 -1.000e-03    0.999    
## ASV0378      4.944e+33  2.274e+37  0.000e+00    1.000    
## ASV1122      9.844e+33  5.743e+36  2.000e-03    0.999    
## ASV0123      1.174e+35  2.298e+38  1.000e-03    1.000    
## ASV2064      2.971e+34  2.632e+37  1.000e-03    0.999    
## ASV4459     -4.566e+33  3.147e+37  0.000e+00    1.000    
## ASV0448      8.855e+32  4.021e+36  0.000e+00    1.000    
## ASV0397      5.454e+33  3.225e+36  2.000e-03    0.999    
## ASV0485     -6.123e+32  8.358e+35 -1.000e-03    0.999    
## ASV1566             NA         NA         NA       NA    
## ASV1365      1.345e+34  1.281e+37  1.000e-03    0.999    
## ASV1065     -6.132e+33  1.217e+37 -1.000e-03    1.000    
## ASV0722      1.223e+34  5.077e+37  0.000e+00    1.000    
## ASV12660            NA         NA         NA       NA    
## ASV0223      9.326e+31  2.937e+36  0.000e+00    1.000    
## ASV0229      2.406e+32  2.545e+37  0.000e+00    1.000    
## ASV0877      1.559e+34  2.751e+37  1.000e-03    1.000    
## ASV0983      3.222e+33  4.074e+37  0.000e+00    1.000    
## ASV0626             NA         NA         NA       NA    
## ASV4146      1.191e+33  1.873e+37  0.000e+00    1.000    
## ASV4175     -1.192e+34  6.769e+37  0.000e+00    1.000    
## ASV2082     -1.738e+33  4.065e+37  0.000e+00    1.000    
## ASV2272      1.819e+33  2.927e+36  1.000e-03    1.000    
## ASV2245      4.247e+34  1.112e+38  0.000e+00    1.000    
## ASV0590             NA         NA         NA       NA    
## ASV0217      9.857e+33  1.205e+37  1.000e-03    0.999    
## ASV0416     -5.675e+33  5.779e+36 -1.000e-03    0.999    
## ASV1056     -6.651e+33  1.592e+37  0.000e+00    1.000    
## ASV7777      1.979e+32  3.526e+35  1.000e-03    1.000    
## ASV0455      1.312e+33  1.582e+36  1.000e-03    0.999    
## ASV0604             NA         NA         NA       NA    
## ASV6100      5.758e+32  1.493e+36  0.000e+00    1.000    
## ASV11359    -1.696e+34  2.293e+37 -1.000e-03    0.999    
## ASV6604      8.731e+33  2.177e+37  0.000e+00    1.000    
## ASV5004     -5.365e+33  2.712e+37  0.000e+00    1.000    
## ASV1483      6.759e+33  2.523e+37  0.000e+00    1.000    
## ASV9773     -2.517e+32  8.033e+35  0.000e+00    1.000    
## ASV4059      3.719e+33  7.644e+36  0.000e+00    1.000    
## ASV1193      2.993e+32  6.384e+36  0.000e+00    1.000    
## ASV4610             NA         NA         NA       NA    
## ASV0742             NA         NA         NA       NA    
## ASV1502     -1.217e+34  3.605e+37  0.000e+00    1.000    
## ASV0195      3.770e+33  1.284e+37  0.000e+00    1.000    
## ASV1213      1.528e+34  3.933e+37  0.000e+00    1.000    
## ASV1648     -3.924e+33  1.206e+37  0.000e+00    1.000    
## ASV6984     -1.787e+33  3.578e+36  0.000e+00    1.000    
## ASV0396     -6.942e+33  4.986e+36 -1.000e-03    0.999    
## ASV4297             NA         NA         NA       NA    
## ASV2622     -4.331e+33  1.160e+37  0.000e+00    1.000    
## ASV3512      1.858e+33  7.366e+36  0.000e+00    1.000    
## ASV2411             NA         NA         NA       NA    
## ASV2291             NA         NA         NA       NA    
## ASV0807     -4.121e+33  3.065e+36 -1.000e-03    0.999    
## ASV1292      6.169e+33  2.642e+37  0.000e+00    1.000    
## ASV1035             NA         NA         NA       NA    
## ASV0070     -2.231e+33  3.194e+36 -1.000e-03    0.999    
## ASV0255      5.166e+32  1.279e+37  0.000e+00    1.000    
## ASV0057      1.611e+33  3.419e+36  0.000e+00    1.000    
## ASV0077     -9.392e+32  9.182e+35 -1.000e-03    0.999    
## ASV0625      6.430e+33  2.133e+37  0.000e+00    1.000    
## ASV2464             NA         NA         NA       NA    
## ASV1315      1.155e+34  3.160e+37  0.000e+00    1.000    
## ASV2673      1.270e+33  3.223e+36  0.000e+00    1.000    
## ASV2161     -1.158e+34  3.815e+37  0.000e+00    1.000    
## ASV0337      7.970e+33  2.902e+37  0.000e+00    1.000    
## ASV7680     -2.264e+33  9.480e+36  0.000e+00    1.000    
## ASV0611     -9.620e+32  5.105e+35 -2.000e-03    0.998    
## ASV3118     -4.495e+33  2.661e+37  0.000e+00    1.000    
## ASV1284      3.493e+33  1.980e+37  0.000e+00    1.000    
## ASV0889             NA         NA         NA       NA    
## ASV4649     -1.280e+34  3.889e+37  0.000e+00    1.000    
## ASV1108      1.812e+32  3.438e+36  0.000e+00    1.000    
## ASV0738     -4.827e+33  1.311e+37  0.000e+00    1.000    
## ASV0473     -4.647e+32  5.244e+36  0.000e+00    1.000    
## ASV0598             NA         NA         NA       NA    
## ASV0429      1.390e+34  3.535e+37  0.000e+00    1.000    
## ASV1549     -1.292e+33  7.928e+36  0.000e+00    1.000    
## ASV1203      3.030e+33  9.238e+36  0.000e+00    1.000    
## ASV4532      5.620e+33  5.879e+36  1.000e-03    0.999    
## ASV0274      6.311e+33  5.906e+36  1.000e-03    0.999    
## ASV0163      9.020e+33  2.429e+37  0.000e+00    1.000    
## ASV1298     -1.716e+33  2.629e+36 -1.000e-03    0.999    
## ASV9424      1.117e+34  3.245e+37  0.000e+00    1.000    
## ASV0412      1.676e+33  1.091e+37  0.000e+00    1.000    
## ASV0284     -2.095e+33  1.114e+37  0.000e+00    1.000    
## ASV0620             NA         NA         NA       NA    
## ASV0153     -1.081e+33  2.380e+36  0.000e+00    1.000    
## ASV0498      2.773e+32  3.417e+36  0.000e+00    1.000    
## ASV0097     -1.844e+32  9.372e+36  0.000e+00    1.000    
## ASV0104      9.679e+32  1.261e+37  0.000e+00    1.000    
## ASV1282      2.504e+33  2.191e+37  0.000e+00    1.000    
## ASV3883     -1.801e+33  1.147e+37  0.000e+00    1.000    
## ASV0801      1.600e+33  6.103e+36  0.000e+00    1.000    
## ASV1611      4.351e+33  2.600e+37  0.000e+00    1.000    
## ASV0227      2.934e+33  1.486e+37  0.000e+00    1.000    
## ASV0833             NA         NA         NA       NA    
## ASV0718      2.498e+33  1.003e+37  0.000e+00    1.000    
## ASV1139             NA         NA         NA       NA    
## ASV0766     -1.056e+34  2.123e+37  0.000e+00    1.000    
## ASV2091     -5.558e+33  3.367e+37  0.000e+00    1.000    
## ASV1238      8.848e+33  1.400e+37  1.000e-03    0.999    
## ASV9193             NA         NA         NA       NA    
## ASV0290     -9.339e+33  3.123e+37  0.000e+00    1.000    
## ASV0231     -2.711e+33  6.415e+36  0.000e+00    1.000    
## ASV0185      2.305e+32  5.670e+35  0.000e+00    1.000    
## ASV2330             NA         NA         NA       NA    
## ASV3119      1.692e+33  1.477e+36  1.000e-03    0.999    
## ASV2368      2.026e+32  6.353e+35  0.000e+00    1.000    
## ASV0122     -4.592e+33  7.572e+36 -1.000e-03    1.000    
## ASV1044     -1.369e+33  2.475e+36 -1.000e-03    1.000    
## ASV0160     -1.445e+33  3.484e+36  0.000e+00    1.000    
## ASV0326     -1.080e+33  3.289e+36  0.000e+00    1.000    
## ASV1388      2.024e+33  2.040e+36  1.000e-03    0.999    
## ASV0792             NA         NA         NA       NA    
## ASV0036     -3.690e+33  1.838e+36 -2.000e-03    0.998    
## ASV2125     -3.618e+32  3.351e+36  0.000e+00    1.000    
## ASV1075      3.311e+33  3.863e+36  1.000e-03    0.999    
## ASV0390     -3.747e+32  1.204e+36  0.000e+00    1.000    
## ASV3790      1.588e+33  5.729e+36  0.000e+00    1.000    
## ASV1535     -6.395e+33  1.860e+37  0.000e+00    1.000    
## ASV0263             NA         NA         NA       NA    
## ASV0675     -5.435e+32  5.894e+36  0.000e+00    1.000    
## ASV3348     -2.178e+33  6.196e+36  0.000e+00    1.000    
## ASV0058     -1.205e+33  1.569e+36 -1.000e-03    0.999    
## ASV4142             NA         NA         NA       NA    
## ASV0059      7.130e+32  8.228e+35  1.000e-03    0.999    
## ASV0013     -7.786e+32  1.535e+37  0.000e+00    1.000    
## ASV0033      5.192e+33  8.043e+36  1.000e-03    0.999    
## ASV4354             NA         NA         NA       NA    
## ASV0022     -1.866e+33  1.244e+37  0.000e+00    1.000    
## ASV0134      6.838e+32  2.711e+36  0.000e+00    1.000    
## ASV0415     -2.899e+33  9.763e+36  0.000e+00    1.000    
## ASV10103            NA         NA         NA       NA    
## ASV1613     -2.181e+32  5.743e+36  0.000e+00    1.000    
## ASV0135      1.180e+31  4.180e+35  0.000e+00    1.000    
## ASV0469             NA         NA         NA       NA    
## ASV0471     -3.078e+33  1.214e+37  0.000e+00    1.000    
## ASV0451      8.272e+32  3.247e+36  0.000e+00    1.000    
## ASV0747      2.441e+32  8.929e+35  0.000e+00    1.000    
## ASV1314     -3.204e+33  1.057e+37  0.000e+00    1.000    
## ASV0425             NA         NA         NA       NA    
## ASV0559     -1.133e+34  2.062e+37 -1.000e-03    1.000    
## ASV0148      2.372e+33  6.980e+36  0.000e+00    1.000    
## ASV0129     -1.963e+33  6.923e+36  0.000e+00    1.000    
## ASV1072     -5.392e+33  1.062e+37 -1.000e-03    1.000    
## ASV2390             NA         NA         NA       NA    
## ASV0548     -4.313e+33  7.294e+36 -1.000e-03    1.000    
## ASV0168     -5.128e+32  4.090e+35 -1.000e-03    0.999    
## ASV0066      1.635e+32  1.353e+36  0.000e+00    1.000    
## ASV0468      1.984e+33  7.011e+36  0.000e+00    1.000    
## ASV0172      8.945e+32  1.315e+36  1.000e-03    0.999    
## ASV0236     -2.539e+32  4.912e+36  0.000e+00    1.000    
## ASV0250     -1.591e+33  7.658e+36  0.000e+00    1.000    
## ASV0338      2.069e+33  1.067e+37  0.000e+00    1.000    
## ASV0450     -6.260e+33  1.353e+37  0.000e+00    1.000    
## ASV0377             NA         NA         NA       NA    
## ASV1022     -1.757e+32  5.718e+35  0.000e+00    1.000    
## ASV6174             NA         NA         NA       NA    
## ASV0786             NA         NA         NA       NA    
## ASV0053     -2.458e+32  6.897e+35  0.000e+00    1.000    
## ASV0697      5.065e+32  6.094e+36  0.000e+00    1.000    
## ASV0785     -1.641e+33  5.283e+36  0.000e+00    1.000    
## ASV1967     -6.916e+33  1.717e+37  0.000e+00    1.000    
## ASV0385     -1.327e+32  1.278e+36  0.000e+00    1.000    
## ASV0295      2.275e+32  7.441e+35  0.000e+00    1.000    
## ASV0072      1.094e+33  6.490e+35  2.000e-03    0.999    
## ASV0157      1.506e+33  3.159e+36  0.000e+00    1.000    
## ASV0501     -6.608e+33  6.836e+36 -1.000e-03    0.999    
## ASV10729    -1.330e+33  1.838e+36 -1.000e-03    0.999    
## ASV1470             NA         NA         NA       NA    
## ASV0050     -2.124e+33  2.917e+37  0.000e+00    1.000    
## ASV0411     -4.211e+32  5.668e+36  0.000e+00    1.000    
## ASV0549      8.365e+32  9.417e+36  0.000e+00    1.000    
## ASV0184      3.552e+30  3.283e+33  1.000e-03    0.999    
## ASV0705     -1.760e+33  8.082e+36  0.000e+00    1.000    
## ASV1715     -1.248e+33  6.190e+36  0.000e+00    1.000    
## ASV0603     -9.083e+32  1.139e+37  0.000e+00    1.000    
## ASV0826             NA         NA         NA       NA    
## ASV0034     -1.386e+33  1.969e+36 -1.000e-03    0.999    
## ASV0838      2.176e+33  6.071e+36  0.000e+00    1.000    
## ASV0614     -7.819e+30  4.586e+36  0.000e+00    1.000    
## ASV0014     -5.161e+33  1.300e+37  0.000e+00    1.000    
## ASV0585             NA         NA         NA       NA    
## ASV0016      3.864e+33  1.236e+37  0.000e+00    1.000    
## ASV5394      4.902e+31  4.740e+35  0.000e+00    1.000    
## ASV0666             NA         NA         NA       NA    
## ASV2085             NA         NA         NA       NA    
## ASV0003      3.287e+33  3.029e+37  0.000e+00    1.000    
## ASV0346      9.616e+32  7.383e+36  0.000e+00    1.000    
## ASV0267     -1.085e+33  2.773e+36  0.000e+00    1.000    
## ASV0353      1.676e+33  8.754e+35  2.000e-03    0.998    
## ASV2419     -2.316e+33  5.407e+36  0.000e+00    1.000    
## ASV0447             NA         NA         NA       NA    
## ASV0654             NA         NA         NA       NA    
## ASV0151     -2.449e+33  6.167e+36  0.000e+00    1.000    
## ASV0065      1.032e+33  1.086e+36  1.000e-03    0.999    
## ASV0527      6.130e+32  3.240e+36  0.000e+00    1.000    
## ASV4055             NA         NA         NA       NA    
## ASV0166             NA         NA         NA       NA    
## ASV0417     -6.496e+32  5.489e+35 -1.000e-03    0.999    
## ASV0078      7.887e+31  3.304e+36  0.000e+00    1.000    
## ASV0322             NA         NA         NA       NA    
## ASV0156     -2.074e+33  3.486e+36 -1.000e-03    1.000    
## ASV0648             NA         NA         NA       NA    
## ASV0407     -1.864e+32  1.218e+36  0.000e+00    1.000    
## ASV2030             NA         NA         NA       NA    
## ASV0300      9.106e+32  2.310e+36  0.000e+00    1.000    
## ASV1150     -2.376e+32  3.940e+36  0.000e+00    1.000    
## ASV0958     -2.550e+32  1.401e+36  0.000e+00    1.000    
## ASV0216             NA         NA         NA       NA    
## ASV0446      4.933e+32  2.747e+36  0.000e+00    1.000    
## ASV0367             NA         NA         NA       NA    
## ASV0200             NA         NA         NA       NA    
## ASV0334             NA         NA         NA       NA    
## ASV1311             NA         NA         NA       NA    
## ASV0458             NA         NA         NA       NA    
## ASV1371             NA         NA         NA       NA    
## ASV0418             NA         NA         NA       NA    
## ASV0004      1.822e+32  7.542e+36  0.000e+00    1.000    
## ASV1943             NA         NA         NA       NA    
## ASV1495     -3.254e+31  3.057e+35  0.000e+00    1.000    
## ASV0901             NA         NA         NA       NA    
## ASV0628             NA         NA         NA       NA    
## ASV0400             NA         NA         NA       NA    
## ASV0116             NA         NA         NA       NA    
## ASV0788     -3.770e+33  4.419e+36 -1.000e-03    0.999    
## ASV0117      1.331e+31  1.230e+36  0.000e+00    1.000    
## ASV3137             NA         NA         NA       NA    
## ASV0001             NA         NA         NA       NA    
## ASV1651     -4.041e+32  6.179e+35 -1.000e-03    0.999    
## ASV1692             NA         NA         NA       NA    
## ASV0660             NA         NA         NA       NA    
## ASV0508             NA         NA         NA       NA    
## ASV1660             NA         NA         NA       NA    
## ASV0233             NA         NA         NA       NA    
## ASV1343             NA         NA         NA       NA    
## ASV0209             NA         NA         NA       NA    
## ASV0193             NA         NA         NA       NA    
## ASV0357     -3.118e+33  1.580e+37  0.000e+00    1.000    
## ASV0198             NA         NA         NA       NA    
## ASV0007             NA         NA         NA       NA    
## ASV1772             NA         NA         NA       NA    
## ASV0009             NA         NA         NA       NA    
## ASV0006             NA         NA         NA       NA    
## ASV0011             NA         NA         NA       NA    
## ASV0015             NA         NA         NA       NA    
## ASV0017             NA         NA         NA       NA    
## ASV0235             NA         NA         NA       NA    
## ASV0382     -7.891e+32  2.685e+36  0.000e+00    1.000    
## ASV2357             NA         NA         NA       NA    
## ASV0567             NA         NA         NA       NA    
## ASV0165             NA         NA         NA       NA    
## ASV0005             NA         NA         NA       NA    
## ASV0384             NA         NA         NA       NA    
## ASV0002             NA         NA         NA       NA    
## ASV3017             NA         NA         NA       NA    
## ASV0091      1.698e+33  1.597e+36  1.000e-03    0.999    
## ASV0186             NA         NA         NA       NA    
## ASV0370             NA         NA         NA       NA    
## ASV0018             NA         NA         NA       NA    
## ASV1377             NA         NA         NA       NA    
## ASV0019             NA         NA         NA       NA    
## ASV0023             NA         NA         NA       NA    
## ASV2194             NA         NA         NA       NA    
## ASV1155             NA         NA         NA       NA    
## ASV0510             NA         NA         NA       NA    
## ASV2371             NA         NA         NA       NA    
## ASV0024             NA         NA         NA       NA    
## ASV2452             NA         NA         NA       NA    
## ASV2332             NA         NA         NA       NA    
## ASV2591             NA         NA         NA       NA    
## ASV0521             NA         NA         NA       NA    
## ASV5542             NA         NA         NA       NA    
## ASV0336             NA         NA         NA       NA    
## ASV10102            NA         NA         NA       NA    
## ASV16823            NA         NA         NA       NA    
## ASV3104             NA         NA         NA       NA    
## ASV0781             NA         NA         NA       NA    
## ASV10899            NA         NA         NA       NA    
## ASV11222            NA         NA         NA       NA    
## ASV11327            NA         NA         NA       NA    
## ASV12458            NA         NA         NA       NA    
## ASV1636             NA         NA         NA       NA    
## ASV1890             NA         NA         NA       NA    
## ASV2898             NA         NA         NA       NA    
## ASV8328             NA         NA         NA       NA    
## ASV0709             NA         NA         NA       NA    
## ASV0856             NA         NA         NA       NA    
## ASV0909             NA         NA         NA       NA    
## ASV0937             NA         NA         NA       NA    
## ASV11390            NA         NA         NA       NA    
## ASV11966            NA         NA         NA       NA    
## ASV12990            NA         NA         NA       NA    
## ASV14797            NA         NA         NA       NA    
## ASV14904            NA         NA         NA       NA    
## ASV15304            NA         NA         NA       NA    
## ASV16696            NA         NA         NA       NA    
## ASV1690             NA         NA         NA       NA    
## ASV2029             NA         NA         NA       NA    
## ASV2834             NA         NA         NA       NA    
## ASV4003             NA         NA         NA       NA    
## ASV4064             NA         NA         NA       NA    
## ASV4294             NA         NA         NA       NA    
## ASV4609             NA         NA         NA       NA    
## ASV6283             NA         NA         NA       NA    
## ASV6491             NA         NA         NA       NA    
## ASV7453             NA         NA         NA       NA    
## ASV7959             NA         NA         NA       NA    
## ASV8219             NA         NA         NA       NA    
## ASV8547             NA         NA         NA       NA    
## ASV9319             NA         NA         NA       NA    
## ASV9382             NA         NA         NA       NA    
## ASV11516            NA         NA         NA       NA    
## ASV14377            NA         NA         NA       NA    
## ASV1867             NA         NA         NA       NA    
## ASV1895             NA         NA         NA       NA    
## ASV3168             NA         NA         NA       NA    
## ASV4449             NA         NA         NA       NA    
## ASV6596             NA         NA         NA       NA    
## ASV7492             NA         NA         NA       NA    
## ASV9854             NA         NA         NA       NA    
## ASV6296             NA         NA         NA       NA    
## ASV4201             NA         NA         NA       NA    
## ASV0552             NA         NA         NA       NA    
## ASV3671             NA         NA         NA       NA    
## ASV3529             NA         NA         NA       NA    
## ASV1060             NA         NA         NA       NA    
## ASV0239             NA         NA         NA       NA    
## ASV5711             NA         NA         NA       NA    
## ASV4152             NA         NA         NA       NA    
## ASV1461             NA         NA         NA       NA    
## ASV2877             NA         NA         NA       NA    
## ASV0012             NA         NA         NA       NA    
## ASV9823             NA         NA         NA       NA    
## ASV0008             NA         NA         NA       NA    
## ASV7832             NA         NA         NA       NA    
## ASV1915             NA         NA         NA       NA    
## ASV0055             NA         NA         NA       NA    
## ASV0032             NA         NA         NA       NA    
## ASV2977             NA         NA         NA       NA    
## ASV0466             NA         NA         NA       NA    
## ASV3866             NA         NA         NA       NA    
## ASV0040             NA         NA         NA       NA    
## ASV0496             NA         NA         NA       NA    
## ASV0052             NA         NA         NA       NA    
## ASV3828             NA         NA         NA       NA    
## ASV1930             NA         NA         NA       NA    
## ASV2126             NA         NA         NA       NA    
## ASV0793             NA         NA         NA       NA    
## ASV0299             NA         NA         NA       NA    
## ASV0208             NA         NA         NA       NA    
## ASV0511             NA         NA         NA       NA    
## ASV1123             NA         NA         NA       NA    
## ASV0099             NA         NA         NA       NA    
## ASV0752             NA         NA         NA       NA    
## ASV0883             NA         NA         NA       NA    
## ASV0683             NA         NA         NA       NA    
## ASV4117             NA         NA         NA       NA    
## ASV2172             NA         NA         NA       NA    
## ASV0330             NA         NA         NA       NA    
## ASV0728             NA         NA         NA       NA    
## ASV0499             NA         NA         NA       NA    
## ASV0120             NA         NA         NA       NA    
## ASV1446             NA         NA         NA       NA    
## ASV17171            NA         NA         NA       NA    
## ASV0533             NA         NA         NA       NA    
## ASV2495             NA         NA         NA       NA    
## ASV5582             NA         NA         NA       NA    
## ASV1488             NA         NA         NA       NA    
## ASV0682             NA         NA         NA       NA    
## ASV0068             NA         NA         NA       NA    
## ASV1987             NA         NA         NA       NA    
## ASV0035             NA         NA         NA       NA    
## ASV7192             NA         NA         NA       NA    
## ASV0873             NA         NA         NA       NA    
## ASV4749             NA         NA         NA       NA    
## ASV2174             NA         NA         NA       NA    
## ASV1476             NA         NA         NA       NA    
## ASV0740             NA         NA         NA       NA    
## ASV0170             NA         NA         NA       NA    
## ASV2466             NA         NA         NA       NA    
## ASV1709             NA         NA         NA       NA    
## ASV6170             NA         NA         NA       NA    
## ASV3673             NA         NA         NA       NA    
## ASV1745             NA         NA         NA       NA    
## ASV0380      2.198e+33  9.375e+36  0.000e+00    1.000    
## ASV0426             NA         NA         NA       NA    
## ASV0202             NA         NA         NA       NA    
## ASV6350             NA         NA         NA       NA    
## ASV0713             NA         NA         NA       NA    
## ASV1822             NA         NA         NA       NA    
## ASV4569             NA         NA         NA       NA    
## ASV0030             NA         NA         NA       NA    
## ASV0331             NA         NA         NA       NA    
## ASV2981             NA         NA         NA       NA    
## ASV0828             NA         NA         NA       NA    
## ASV2440             NA         NA         NA       NA    
## ASV3006             NA         NA         NA       NA    
## ASV3875             NA         NA         NA       NA    
## ASV4511             NA         NA         NA       NA    
## ASV4700             NA         NA         NA       NA    
## ASV5804             NA         NA         NA       NA    
## ASV6826             NA         NA         NA       NA    
## ASV7280             NA         NA         NA       NA    
## ASV7535             NA         NA         NA       NA    
## ASV0651             NA         NA         NA       NA    
## ASV0913             NA         NA         NA       NA    
## ASV10832            NA         NA         NA       NA    
## ASV1117             NA         NA         NA       NA    
## ASV11329            NA         NA         NA       NA    
## ASV13209            NA         NA         NA       NA    
## ASV1345             NA         NA         NA       NA    
## ASV1719             NA         NA         NA       NA    
## ASV1886             NA         NA         NA       NA    
## ASV2158             NA         NA         NA       NA    
## ASV2189             NA         NA         NA       NA    
## ASV2257             NA         NA         NA       NA    
## ASV2283             NA         NA         NA       NA    
## ASV2328             NA         NA         NA       NA    
## ASV2434             NA         NA         NA       NA    
## ASV2648             NA         NA         NA       NA    
## ASV2698             NA         NA         NA       NA    
## ASV2775             NA         NA         NA       NA    
## ASV3171             NA         NA         NA       NA    
## ASV3227             NA         NA         NA       NA    
## ASV3397             NA         NA         NA       NA    
## ASV3444             NA         NA         NA       NA    
## ASV3556             NA         NA         NA       NA    
## ASV3606             NA         NA         NA       NA    
## ASV4190             NA         NA         NA       NA    
## ASV4197             NA         NA         NA       NA    
## ASV4722             NA         NA         NA       NA    
## ASV4765             NA         NA         NA       NA    
## ASV4809             NA         NA         NA       NA    
## ASV4846             NA         NA         NA       NA    
## ASV4903             NA         NA         NA       NA    
## ASV4944             NA         NA         NA       NA    
## ASV5151             NA         NA         NA       NA    
## ASV5413             NA         NA         NA       NA    
## ASV5537             NA         NA         NA       NA    
## ASV5688             NA         NA         NA       NA    
## ASV5752             NA         NA         NA       NA    
## ASV6122             NA         NA         NA       NA    
## ASV6135             NA         NA         NA       NA    
## ASV6188             NA         NA         NA       NA    
## ASV6216             NA         NA         NA       NA    
## ASV6242             NA         NA         NA       NA    
## ASV6383             NA         NA         NA       NA    
## ASV6781             NA         NA         NA       NA    
## ASV6799             NA         NA         NA       NA    
## ASV7374             NA         NA         NA       NA    
## ASV7539             NA         NA         NA       NA    
## ASV8591             NA         NA         NA       NA    
## ASV8637             NA         NA         NA       NA    
## ASV12796            NA         NA         NA       NA    
## ASV1934             NA         NA         NA       NA    
## ASV22549            NA         NA         NA       NA    
## ASV29857            NA         NA         NA       NA    
## ASV3215             NA         NA         NA       NA    
## ASV3236             NA         NA         NA       NA    
## ASV3954             NA         NA         NA       NA    
## ASV4850             NA         NA         NA       NA    
## ASV5225             NA         NA         NA       NA    
## ASV5532             NA         NA         NA       NA    
## ASV7258             NA         NA         NA       NA    
## ASV9474             NA         NA         NA       NA    
## ASV11857            NA         NA         NA       NA    
## ASV1202             NA         NA         NA       NA    
## ASV14742            NA         NA         NA       NA    
## ASV16652            NA         NA         NA       NA    
## ASV2019             NA         NA         NA       NA    
## ASV2410             NA         NA         NA       NA    
## ASV2718             NA         NA         NA       NA    
## ASV2738             NA         NA         NA       NA    
## ASV2876             NA         NA         NA       NA    
## ASV3177             NA         NA         NA       NA    
## ASV4367             NA         NA         NA       NA    
## ASV4635             NA         NA         NA       NA    
## ASV4896             NA         NA         NA       NA    
## ASV4907             NA         NA         NA       NA    
## ASV5230             NA         NA         NA       NA    
## ASV6509             NA         NA         NA       NA    
## ASV7376             NA         NA         NA       NA    
## ASV8163             NA         NA         NA       NA    
## ASV8195             NA         NA         NA       NA    
## ASV8923             NA         NA         NA       NA    
## ASV9666             NA         NA         NA       NA    
## ASV1482             NA         NA         NA       NA    
## ASV2726             NA         NA         NA       NA    
## ASV3281             NA         NA         NA       NA    
## ASV4235             NA         NA         NA       NA    
## ASV4808             NA         NA         NA       NA    
## ASV4861             NA         NA         NA       NA    
## ASV5276             NA         NA         NA       NA    
## ASV5837             NA         NA         NA       NA    
## ASV7098             NA         NA         NA       NA    
## ASV8451             NA         NA         NA       NA    
## ASV8694             NA         NA         NA       NA    
## ASV0905             NA         NA         NA       NA    
## ASV2900             NA         NA         NA       NA    
## ASV3963             NA         NA         NA       NA    
## ASV0041             NA         NA         NA       NA    
## ASV1865             NA         NA         NA       NA    
## ASV1140             NA         NA         NA       NA    
## ASV1179             NA         NA         NA       NA    
## ASV0279             NA         NA         NA       NA    
## ASV0043             NA         NA         NA       NA    
## ASV2097             NA         NA         NA       NA    
## ASV0309             NA         NA         NA       NA    
## ASV0607             NA         NA         NA       NA    
## ASV0025             NA         NA         NA       NA    
## ASV2284             NA         NA         NA       NA    
## ASV0556             NA         NA         NA       NA    
## ASV5040             NA         NA         NA       NA    
## ASV2924             NA         NA         NA       NA    
## ASV1331             NA         NA         NA       NA    
## ASV0506             NA         NA         NA       NA    
## ASV1514             NA         NA         NA       NA    
## ASV2144             NA         NA         NA       NA    
## ASV2265             NA         NA         NA       NA    
## ASV5156             NA         NA         NA       NA    
## ASV5534             NA         NA         NA       NA    
## ASV5747             NA         NA         NA       NA    
## ASV6657             NA         NA         NA       NA    
## ASV0658             NA         NA         NA       NA    
## ASV0716             NA         NA         NA       NA    
## ASV1657             NA         NA         NA       NA    
## ASV1885             NA         NA         NA       NA    
## ASV2333             NA         NA         NA       NA    
## ASV3375             NA         NA         NA       NA    
## ASV4317             NA         NA         NA       NA    
## ASV9599             NA         NA         NA       NA    
## ASV0175     -3.581e+31  5.063e+36  0.000e+00    1.000    
## ASV1032             NA         NA         NA       NA    
## ASV1235             NA         NA         NA       NA    
## ASV1262             NA         NA         NA       NA    
## ASV1320             NA         NA         NA       NA    
## ASV13797            NA         NA         NA       NA    
## ASV1491             NA         NA         NA       NA    
## ASV15014            NA         NA         NA       NA    
## ASV1510             NA         NA         NA       NA    
## ASV1551             NA         NA         NA       NA    
## ASV1919             NA         NA         NA       NA    
## ASV2114             NA         NA         NA       NA    
## ASV21486            NA         NA         NA       NA    
## ASV2448             NA         NA         NA       NA    
## ASV2589             NA         NA         NA       NA    
## ASV2608             NA         NA         NA       NA    
## ASV2786             NA         NA         NA       NA    
## ASV2827             NA         NA         NA       NA    
## ASV2872             NA         NA         NA       NA    
## ASV3125             NA         NA         NA       NA    
## ASV3247             NA         NA         NA       NA    
## ASV3451             NA         NA         NA       NA    
## ASV3465             NA         NA         NA       NA    
## ASV3809             NA         NA         NA       NA    
## ASV4006             NA         NA         NA       NA    
## ASV4046             NA         NA         NA       NA    
## ASV4938             NA         NA         NA       NA    
## ASV5435             NA         NA         NA       NA    
## ASV5605             NA         NA         NA       NA    
## ASV5635             NA         NA         NA       NA    
## ASV5743             NA         NA         NA       NA    
## ASV6627             NA         NA         NA       NA    
## ASV6785             NA         NA         NA       NA    
## ASV7368             NA         NA         NA       NA    
## ASV9118             NA         NA         NA       NA    
## ASV9135             NA         NA         NA       NA    
## ASV9435             NA         NA         NA       NA    
## ASV9671             NA         NA         NA       NA    
## ASV0387             NA         NA         NA       NA    
## ASV0454             NA         NA         NA       NA    
## ASV0751             NA         NA         NA       NA    
## ASV1081             NA         NA         NA       NA    
## ASV1332             NA         NA         NA       NA    
## ASV2659             NA         NA         NA       NA    
## ASV2979             NA         NA         NA       NA    
## ASV4184             NA         NA         NA       NA    
## ASV6198             NA         NA         NA       NA    
## ASV7454             NA         NA         NA       NA    
## ASV8198             NA         NA         NA       NA    
## ASV0855             NA         NA         NA       NA    
## ASV10092            NA         NA         NA       NA    
## ASV1532             NA         NA         NA       NA    
## ASV2553             NA         NA         NA       NA    
## ASV2741             NA         NA         NA       NA    
## ASV4095             NA         NA         NA       NA    
## ASV5295             NA         NA         NA       NA    
## ASV5787             NA         NA         NA       NA    
## ASV9455             NA         NA         NA       NA    
## ASV10879            NA         NA         NA       NA    
## ASV3997             NA         NA         NA       NA    
## ASV6760             NA         NA         NA       NA    
## ASV6990             NA         NA         NA       NA    
## ASV9560             NA         NA         NA       NA    
## ASV0220             NA         NA         NA       NA    
## ASV2518             NA         NA         NA       NA    
## ASV3615             NA         NA         NA       NA    
## ASV0075             NA         NA         NA       NA    
## ASV8070             NA         NA         NA       NA    
## ASV1658             NA         NA         NA       NA    
## ASV0773             NA         NA         NA       NA    
## ASV0799             NA         NA         NA       NA    
## ASV1839             NA         NA         NA       NA    
## ASV0265             NA         NA         NA       NA    
## ASV3741             NA         NA         NA       NA    
## ASV0847      5.919e+33  1.280e+37  0.000e+00    1.000    
## ASV1026             NA         NA         NA       NA    
## ASV1222             NA         NA         NA       NA    
## ASV0729             NA         NA         NA       NA    
## ASV0143             NA         NA         NA       NA    
## ASV1328             NA         NA         NA       NA    
## ASV9078             NA         NA         NA       NA    
## ASV0027             NA         NA         NA       NA    
## ASV0546             NA         NA         NA       NA    
## ASV1136             NA         NA         NA       NA    
## ASV3081             NA         NA         NA       NA    
## ASV0531             NA         NA         NA       NA    
## ASV2525             NA         NA         NA       NA    
## ASV1083             NA         NA         NA       NA    
## ASV0424             NA         NA         NA       NA    
## ASV0644             NA         NA         NA       NA    
## ASV6007             NA         NA         NA       NA    
## ASV0564             NA         NA         NA       NA    
## ASV1938             NA         NA         NA       NA    
## ASV6516             NA         NA         NA       NA    
## ASV0503             NA         NA         NA       NA    
## ASV6913             NA         NA         NA       NA    
## ASV0164             NA         NA         NA       NA    
## ASV1576             NA         NA         NA       NA    
## ASV1725             NA         NA         NA       NA    
## ASV4501             NA         NA         NA       NA    
## ASV10678            NA         NA         NA       NA    
## ASV0944             NA         NA         NA       NA    
## ASV2292             NA         NA         NA       NA    
## ASV1090             NA         NA         NA       NA    
## ASV9117             NA         NA         NA       NA    
## ASV0285             NA         NA         NA       NA    
## ASV0463             NA         NA         NA       NA    
## ASV3199             NA         NA         NA       NA    
## ASV0150             NA         NA         NA       NA    
## ASV6583             NA         NA         NA       NA    
## ASV0392             NA         NA         NA       NA    
## ASV14007            NA         NA         NA       NA    
## ASV0177             NA         NA         NA       NA    
## ASV6448             NA         NA         NA       NA    
## ASV5399             NA         NA         NA       NA    
## ASV0277             NA         NA         NA       NA    
## ASV2599             NA         NA         NA       NA    
## ASV13465            NA         NA         NA       NA    
## ASV2412             NA         NA         NA       NA    
## ASV0423             NA         NA         NA       NA    
## ASV5187             NA         NA         NA       NA    
## ASV0701             NA         NA         NA       NA    
## ASV4248             NA         NA         NA       NA    
## ASV0519             NA         NA         NA       NA    
## ASV0764             NA         NA         NA       NA    
## ASV5385             NA         NA         NA       NA    
## ASV3021             NA         NA         NA       NA    
## ASV4119             NA         NA         NA       NA    
## ASV2534             NA         NA         NA       NA    
## ASV1061             NA         NA         NA       NA    
## ASV0670             NA         NA         NA       NA    
## ASV1384             NA         NA         NA       NA    
## ASV1981             NA         NA         NA       NA    
## ASV9632             NA         NA         NA       NA    
## ASV4564             NA         NA         NA       NA    
## ASV5289             NA         NA         NA       NA    
## ASV0516             NA         NA         NA       NA    
## ASV1463             NA         NA         NA       NA    
## ASV0969             NA         NA         NA       NA    
## ASV1113             NA         NA         NA       NA    
## ASV1234             NA         NA         NA       NA    
## ASV3814             NA         NA         NA       NA    
## ASV1000     -6.810e+33  1.279e+37 -1.000e-03    1.000    
## ASV0079             NA         NA         NA       NA    
## ASV0145     -9.941e+32  3.969e+36  0.000e+00    1.000    
## ASV0457             NA         NA         NA       NA    
## ASV1485             NA         NA         NA       NA    
## ASV0535             NA         NA         NA       NA    
## ASV0259             NA         NA         NA       NA    
## ASV0570             NA         NA         NA       NA    
## ASV0906             NA         NA         NA       NA    
## ASV1748             NA         NA         NA       NA    
## ASV5520             NA         NA         NA       NA    
## ASV2288             NA         NA         NA       NA    
## ASV1887             NA         NA         NA       NA    
## ASV0374             NA         NA         NA       NA    
## ASV0823             NA         NA         NA       NA    
## ASV0717             NA         NA         NA       NA    
## ASV0431             NA         NA         NA       NA    
## ASV1030             NA         NA         NA       NA    
## ASV1082             NA         NA         NA       NA    
## ASV2684             NA         NA         NA       NA    
## ASV0051             NA         NA         NA       NA    
## ASV0513             NA         NA         NA       NA    
## ASV0581             NA         NA         NA       NA    
## ASV7282             NA         NA         NA       NA    
## ASV3009             NA         NA         NA       NA    
## ASV2106             NA         NA         NA       NA    
## ASV1012             NA         NA         NA       NA    
## ASV0921             NA         NA         NA       NA    
## ASV0010             NA         NA         NA       NA    
## ASV1178             NA         NA         NA       NA    
## ASV2848             NA         NA         NA       NA    
## ASV0586      4.507e+33  4.181e+36  1.000e-03    0.999    
## ASV4225             NA         NA         NA       NA    
## ASV2156             NA         NA         NA       NA    
## ASV9778             NA         NA         NA       NA    
## ASV0493             NA         NA         NA       NA    
## ASV3770             NA         NA         NA       NA    
## ASV0470             NA         NA         NA       NA    
## ASV0262             NA         NA         NA       NA    
## ASV0998             NA         NA         NA       NA    
## ASV7708             NA         NA         NA       NA    
## ASV0453             NA         NA         NA       NA    
## ASV0044             NA         NA         NA       NA    
## ASV5490             NA         NA         NA       NA    
## ASV2638             NA         NA         NA       NA    
## ASV0829             NA         NA         NA       NA    
## ASV0601             NA         NA         NA       NA    
## ASV0234             NA         NA         NA       NA    
## ASV0133             NA         NA         NA       NA    
## ASV0323             NA         NA         NA       NA    
## ASV0854             NA         NA         NA       NA    
## ASV0110             NA         NA         NA       NA    
## ASV0816             NA         NA         NA       NA    
## ASV1031             NA         NA         NA       NA    
## ASV0144      6.521e+32  5.367e+35  1.000e-03    0.999    
## ASV0020             NA         NA         NA       NA    
## ASV0962             NA         NA         NA       NA    
## ASV0794             NA         NA         NA       NA    
## ASV7117             NA         NA         NA       NA    
## ASV1008             NA         NA         NA       NA    
## ASV0096             NA         NA         NA       NA    
## ASV0128             NA         NA         NA       NA    
## ASV5232             NA         NA         NA       NA    
## ASV0031             NA         NA         NA       NA    
## ASV1744             NA         NA         NA       NA    
## ASV0289     -1.078e+33  4.590e+36  0.000e+00    1.000    
## ASV7413             NA         NA         NA       NA    
## ASV0822             NA         NA         NA       NA    
## ASV8111             NA         NA         NA       NA    
## ASV0687             NA         NA         NA       NA    
## ASV0112             NA         NA         NA       NA    
## ASV0987             NA         NA         NA       NA    
## ASV5332             NA         NA         NA       NA    
## ASV1129             NA         NA         NA       NA    
## ASV1274             NA         NA         NA       NA    
## ASV0119             NA         NA         NA       NA    
## ASV0890             NA         NA         NA       NA    
## ASV0848     -3.263e+33  6.580e+36  0.000e+00    1.000    
## ASV5944             NA         NA         NA       NA    
## ASV19741            NA         NA         NA       NA    
## ASV0504             NA         NA         NA       NA    
## ASV2146             NA         NA         NA       NA    
## ASV0089             NA         NA         NA       NA    
## ASV2301             NA         NA         NA       NA    
## ASV2982             NA         NA         NA       NA    
## ASV0891             NA         NA         NA       NA    
## ASV0093             NA         NA         NA       NA    
## ASV0042             NA         NA         NA       NA    
## ASV0980             NA         NA         NA       NA    
## ASV0069             NA         NA         NA       NA    
## ASV1364             NA         NA         NA       NA    
## ASV0524             NA         NA         NA       NA    
## ASV0435             NA         NA         NA       NA    
## ASV0517             NA         NA         NA       NA    
## ASV3167             NA         NA         NA       NA    
## ASV4280             NA         NA         NA       NA    
## ASV1158             NA         NA         NA       NA    
## ASV2214             NA         NA         NA       NA    
## ASV0544             NA         NA         NA       NA    
## ASV5326             NA         NA         NA       NA    
## ASV3765             NA         NA         NA       NA    
## ASV4646             NA         NA         NA       NA    
## ASV0090             NA         NA         NA       NA    
## ASV3680             NA         NA         NA       NA    
## ASV0111      1.611e+33  6.472e+36  0.000e+00    1.000    
## ASV0768             NA         NA         NA       NA    
## ASV4862             NA         NA         NA       NA    
## ASV1742             NA         NA         NA       NA    
## ASV3701             NA         NA         NA       NA    
## ASV2386             NA         NA         NA       NA    
## ASV0375             NA         NA         NA       NA    
## ASV2796             NA         NA         NA       NA    
## ASV1369             NA         NA         NA       NA    
## ASV10272            NA         NA         NA       NA    
## ASV10354            NA         NA         NA       NA    
## ASV1067             NA         NA         NA       NA    
## ASV1900             NA         NA         NA       NA    
## ASV4079             NA         NA         NA       NA    
## ASV4149             NA         NA         NA       NA    
## ASV5140             NA         NA         NA       NA    
## ASV10782            NA         NA         NA       NA    
## ASV4273             NA         NA         NA       NA    
## ASV8121             NA         NA         NA       NA    
## ASV8438             NA         NA         NA       NA    
## ASV9390             NA         NA         NA       NA    
## ASV1340             NA         NA         NA       NA    
## ASV2650             NA         NA         NA       NA    
## ASV4674             NA         NA         NA       NA    
## ASV10492            NA         NA         NA       NA    
## ASV11430            NA         NA         NA       NA    
## ASV12135            NA         NA         NA       NA    
## ASV14970            NA         NA         NA       NA    
## ASV1954             NA         NA         NA       NA    
## ASV2613             NA         NA         NA       NA    
## ASV2757             NA         NA         NA       NA    
## ASV2909             NA         NA         NA       NA    
## ASV2954             NA         NA         NA       NA    
## ASV2969             NA         NA         NA       NA    
## ASV3410             NA         NA         NA       NA    
## ASV3575             NA         NA         NA       NA    
## ASV4275             NA         NA         NA       NA    
## ASV4652             NA         NA         NA       NA    
## ASV4761             NA         NA         NA       NA    
## ASV6003             NA         NA         NA       NA    
## ASV6110             NA         NA         NA       NA    
## ASV7427             NA         NA         NA       NA    
## ASV8092             NA         NA         NA       NA    
## ASV8169             NA         NA         NA       NA    
## ASV9693             NA         NA         NA       NA    
## ASV10913            NA         NA         NA       NA    
## ASV1979             NA         NA         NA       NA    
## ASV3772             NA         NA         NA       NA    
## ASV0113             NA         NA         NA       NA    
## ASV1800     -7.688e+32  1.585e+36  0.000e+00    1.000    
## ASV2335             NA         NA         NA       NA    
## ASV0692             NA         NA         NA       NA    
## ASV1120             NA         NA         NA       NA    
## ASV1434             NA         NA         NA       NA    
## ASV0076             NA         NA         NA       NA    
## ASV0361             NA         NA         NA       NA    
## ASV2231     -8.934e+32  5.177e+36  0.000e+00    1.000    
## ASV2018             NA         NA         NA       NA    
## ASV1529             NA         NA         NA       NA    
## ASV0841             NA         NA         NA       NA    
## ASV2556             NA         NA         NA       NA    
## ASV2777             NA         NA         NA       NA    
## ASV0355             NA         NA         NA       NA    
## ASV5169             NA         NA         NA       NA    
## ASV3091             NA         NA         NA       NA    
## ASV2435             NA         NA         NA       NA    
## ASV6822             NA         NA         NA       NA    
## ASV12605            NA         NA         NA       NA    
## ASV0286             NA         NA         NA       NA    
## ASV0074             NA         NA         NA       NA    
## ASV2485             NA         NA         NA       NA    
## ASV1233             NA         NA         NA       NA    
## ASV0356             NA         NA         NA       NA    
## ASV2918             NA         NA         NA       NA    
## ASV1427             NA         NA         NA       NA    
## ASV1409             NA         NA         NA       NA    
## ASV0770             NA         NA         NA       NA    
## ASV1403             NA         NA         NA       NA    
## ASV0314             NA         NA         NA       NA    
## ASV0187             NA         NA         NA       NA    
## ASV0313             NA         NA         NA       NA    
## ASV1087             NA         NA         NA       NA    
## ASV1970             NA         NA         NA       NA    
## ASV0754             NA         NA         NA       NA    
## ASV3775             NA         NA         NA       NA    
## ASV0132             NA         NA         NA       NA    
## ASV2329             NA         NA         NA       NA    
## ASV0561             NA         NA         NA       NA    
## ASV0130             NA         NA         NA       NA    
## ASV0226             NA         NA         NA       NA    
## ASV12648            NA         NA         NA       NA    
## ASV0204     -2.008e+33  8.502e+36  0.000e+00    1.000    
## ASV0767             NA         NA         NA       NA    
## ASV0335             NA         NA         NA       NA    
## ASV5901     -6.731e+33  2.253e+37  0.000e+00    1.000    
## ASV0596             NA         NA         NA       NA    
## ASV9271             NA         NA         NA       NA    
## ASV0904             NA         NA         NA       NA    
## ASV15270            NA         NA         NA       NA    
## ASV0990             NA         NA         NA       NA    
## ASV0155             NA         NA         NA       NA    
## ASV0086             NA         NA         NA       NA    
## ASV2581     -1.695e+32  3.090e+36  0.000e+00    1.000    
## ASV1579             NA         NA         NA       NA    
## ASV7730             NA         NA         NA       NA    
## ASV0897             NA         NA         NA       NA    
## ASV1975             NA         NA         NA       NA    
## ASV0759             NA         NA         NA       NA    
## ASV3082             NA         NA         NA       NA    
## ASV3195             NA         NA         NA       NA    
## ASV0427             NA         NA         NA       NA    
## ASV2674             NA         NA         NA       NA    
## ASV1500             NA         NA         NA       NA    
## ASV0102     -3.954e+33  2.600e+37  0.000e+00    1.000    
## ASV1217             NA         NA         NA       NA    
## ASV4998             NA         NA         NA       NA    
## ASV2890             NA         NA         NA       NA    
## ASV0672     -2.250e+33  3.765e+36 -1.000e-03    1.000    
## ASV6960             NA         NA         NA       NA    
## ASV0821             NA         NA         NA       NA    
## ASV1995             NA         NA         NA       NA    
## ASV0211             NA         NA         NA       NA    
## ASV0364             NA         NA         NA       NA    
## ASV3616             NA         NA         NA       NA    
## ASV1996             NA         NA         NA       NA    
## ASV1881             NA         NA         NA       NA    
## ASV1089             NA         NA         NA       NA    
## ASV1450             NA         NA         NA       NA    
## ASV4643             NA         NA         NA       NA    
## ASV3458             NA         NA         NA       NA    
## ASV2543             NA         NA         NA       NA    
## ASV3306             NA         NA         NA       NA    
## ASV0218             NA         NA         NA       NA    
## ASV3727             NA         NA         NA       NA    
## ASV4394             NA         NA         NA       NA    
## ASV2636             NA         NA         NA       NA    
## ASV5116             NA         NA         NA       NA    
## ASV1394             NA         NA         NA       NA    
## ASV0656             NA         NA         NA       NA    
## ASV0475             NA         NA         NA       NA    
## ASV1042             NA         NA         NA       NA    
## ASV1199             NA         NA         NA       NA    
## ASV12962            NA         NA         NA       NA    
## ASV0853             NA         NA         NA       NA    
## ASV5069             NA         NA         NA       NA    
## ASV7825             NA         NA         NA       NA    
## ASV0339             NA         NA         NA       NA    
## ASV2965             NA         NA         NA       NA    
## ASV2347             NA         NA         NA       NA    
## ASV0541             NA         NA         NA       NA    
## ASV0369     -2.789e+33  1.253e+36 -2.000e-03    0.998    
## ASV0171             NA         NA         NA       NA    
## ASV2235             NA         NA         NA       NA    
## ASV5809             NA         NA         NA       NA    
## ASV1267             NA         NA         NA       NA    
## ASV0207             NA         NA         NA       NA    
## ASV3126             NA         NA         NA       NA    
## ASV0183             NA         NA         NA       NA    
## ASV1792             NA         NA         NA       NA    
## ASV2001             NA         NA         NA       NA    
## ASV5732             NA         NA         NA       NA    
## ASV2857             NA         NA         NA       NA    
## ASV1052             NA         NA         NA       NA    
## ASV3226             NA         NA         NA       NA    
## ASV3766             NA         NA         NA       NA    
## ASV0982             NA         NA         NA       NA    
## ASV0489             NA         NA         NA       NA    
## ASV3990             NA         NA         NA       NA    
## ASV0433             NA         NA         NA       NA    
## ASV0684             NA         NA         NA       NA    
## ASV0063     -5.928e+32  2.858e+36  0.000e+00    1.000    
## ASV1399             NA         NA         NA       NA    
## ASV3093             NA         NA         NA       NA    
## ASV1771             NA         NA         NA       NA    
## ASV7910             NA         NA         NA       NA    
## ASV3718             NA         NA         NA       NA    
## ASV0039             NA         NA         NA       NA    
## ASV6469             NA         NA         NA       NA    
## ASV8186             NA         NA         NA       NA    
## ASV1091             NA         NA         NA       NA    
## ASV16930            NA         NA         NA       NA    
## ASV7234             NA         NA         NA       NA    
## ASV1560             NA         NA         NA       NA    
## ASV2968             NA         NA         NA       NA    
## ASV3824             NA         NA         NA       NA    
## ASV0442             NA         NA         NA       NA    
## ASV0677             NA         NA         NA       NA    
## ASV4796             NA         NA         NA       NA    
## ASV2206             NA         NA         NA       NA    
## ASV2884             NA         NA         NA       NA    
## ASV0482             NA         NA         NA       NA    
## ASV1273             NA         NA         NA       NA    
## ASV1910             NA         NA         NA       NA    
## ASV0105             NA         NA         NA       NA    
## ASV0149             NA         NA         NA       NA    
## ASV5007             NA         NA         NA       NA    
## ASV0757             NA         NA         NA       NA    
## ASV11952            NA         NA         NA       NA    
## ASV4102      2.853e+33  7.504e+36  0.000e+00    1.000    
## ASV1034             NA         NA         NA       NA    
## ASV0753             NA         NA         NA       NA    
## ASV2323             NA         NA         NA       NA    
## ASV0881             NA         NA         NA       NA    
## ASV3730             NA         NA         NA       NA    
## ASV2685             NA         NA         NA       NA    
## ASV3826             NA         NA         NA       NA    
## ASV0689             NA         NA         NA       NA    
## ASV4315             NA         NA         NA       NA    
## ASV1239             NA         NA         NA       NA    
## ASV3147             NA         NA         NA       NA    
## ASV3454             NA         NA         NA       NA    
## ASV4411             NA         NA         NA       NA    
## ASV3007             NA         NA         NA       NA    
## ASV6151             NA         NA         NA       NA    
## ASV0834             NA         NA         NA       NA    
## ASV1231             NA         NA         NA       NA    
## ASV0643             NA         NA         NA       NA    
## ASV0924             NA         NA         NA       NA    
## ASV3238             NA         NA         NA       NA    
## ASV1276             NA         NA         NA       NA    
## ASV5503             NA         NA         NA       NA    
## ASV0404             NA         NA         NA       NA    
## ASV3430             NA         NA         NA       NA    
## ASV5401             NA         NA         NA       NA    
## ASV3426     -1.044e+33  1.557e+36 -1.000e-03    0.999    
## ASV0777             NA         NA         NA       NA    
## ASV11093            NA         NA         NA       NA    
## ASV2170             NA         NA         NA       NA    
## ASV3861             NA         NA         NA       NA    
## ASV1723             NA         NA         NA       NA    
## ASV2460             NA         NA         NA       NA    
## ASV1218             NA         NA         NA       NA    
## ASV0436             NA         NA         NA       NA    
## ASV0919             NA         NA         NA       NA    
## ASV0577             NA         NA         NA       NA    
## ASV2517             NA         NA         NA       NA    
## ASV2628             NA         NA         NA       NA    
## ASV1743             NA         NA         NA       NA    
## ASV1678             NA         NA         NA       NA    
## ASV0315             NA         NA         NA       NA    
## ASV0253             NA         NA         NA       NA    
## ASV1363             NA         NA         NA       NA    
## ASV0995             NA         NA         NA       NA    
## ASV4185             NA         NA         NA       NA    
## ASV0782             NA         NA         NA       NA    
## ASV3240             NA         NA         NA       NA    
## ASV1392             NA         NA         NA       NA    
## ASV8488             NA         NA         NA       NA    
## ASV2814             NA         NA         NA       NA    
## ASV0678             NA         NA         NA       NA    
## ASV1295             NA         NA         NA       NA    
## ASV7517             NA         NA         NA       NA    
## ASV2996             NA         NA         NA       NA    
## ASV2882             NA         NA         NA       NA    
## ASV1317             NA         NA         NA       NA    
## ASV9106             NA         NA         NA       NA    
## ASV9688             NA         NA         NA       NA    
## ASV6181             NA         NA         NA       NA    
## ASV2936      1.559e+33  2.228e+36  1.000e-03    0.999    
## ASV0192             NA         NA         NA       NA    
## ASV2509             NA         NA         NA       NA    
## ASV0863             NA         NA         NA       NA    
## ASV2762             NA         NA         NA       NA    
## ASV4904             NA         NA         NA       NA    
## ASV0571             NA         NA         NA       NA    
## ASV13304            NA         NA         NA       NA    
## ASV6863             NA         NA         NA       NA    
## ASV4844             NA         NA         NA       NA    
## ASV10779            NA         NA         NA       NA    
## ASV7921             NA         NA         NA       NA    
## ASV8458             NA         NA         NA       NA    
## ASV2593             NA         NA         NA       NA    
## ASV4410             NA         NA         NA       NA    
## ASV0593             NA         NA         NA       NA    
## ASV2669             NA         NA         NA       NA    
## ASV0868             NA         NA         NA       NA    
## ASV3123             NA         NA         NA       NA    
## ASV3482             NA         NA         NA       NA    
## ASV2552             NA         NA         NA       NA    
## ASV0723             NA         NA         NA       NA    
## ASV0526             NA         NA         NA       NA    
## ASV4623             NA         NA         NA       NA    
## ASV2070             NA         NA         NA       NA    
## ASV1198             NA         NA         NA       NA    
## ASV3034             NA         NA         NA       NA    
## ASV1208             NA         NA         NA       NA    
## ASV4860             NA         NA         NA       NA    
## ASV2493             NA         NA         NA       NA    
## ASV4217             NA         NA         NA       NA    
## ASV1516             NA         NA         NA       NA    
## ASV1186             NA         NA         NA       NA    
## ASV1906             NA         NA         NA       NA    
## ASV8220             NA         NA         NA       NA    
## ASV4227             NA         NA         NA       NA    
## ASV1013             NA         NA         NA       NA    
## ASV7952             NA         NA         NA       NA    
## ASV5923             NA         NA         NA       NA    
## ASV0190             NA         NA         NA       NA    
## ASV0491     -5.012e+32  1.469e+36  0.000e+00    1.000    
## ASV9535             NA         NA         NA       NA    
## ASV9947             NA         NA         NA       NA    
## ASV6518             NA         NA         NA       NA    
## ASV1741             NA         NA         NA       NA    
## ASV1874             NA         NA         NA       NA    
## ASV2150             NA         NA         NA       NA    
## ASV5262             NA         NA         NA       NA    
## ASV1729             NA         NA         NA       NA    
## ASV1522             NA         NA         NA       NA    
## ASV3250             NA         NA         NA       NA    
## ASV4338             NA         NA         NA       NA    
## ASV1386             NA         NA         NA       NA    
## ASV0694             NA         NA         NA       NA    
## ASV2026             NA         NA         NA       NA    
## ASV0191             NA         NA         NA       NA    
## ASV1641             NA         NA         NA       NA    
## ASV1326             NA         NA         NA       NA    
## ASV4786             NA         NA         NA       NA    
## ASV0342             NA         NA         NA       NA    
## ASV3025             NA         NA         NA       NA    
## ASV6533             NA         NA         NA       NA    
## ASV1898             NA         NA         NA       NA    
## ASV1940             NA         NA         NA       NA    
## ASV4968             NA         NA         NA       NA    
## ASV3401             NA         NA         NA       NA    
## ASV3211             NA         NA         NA       NA    
## ASV1489             NA         NA         NA       NA    
## ASV4139             NA         NA         NA       NA    
## ASV6059             NA         NA         NA       NA    
## ASV0918             NA         NA         NA       NA    
## ASV1449      1.445e+33  2.907e+36  0.000e+00    1.000    
## ASV5652             NA         NA         NA       NA    
## ASV4091             NA         NA         NA       NA    
## ASV7638             NA         NA         NA       NA    
## ASV6525             NA         NA         NA       NA    
## ASV8959             NA         NA         NA       NA    
## ASV0699             NA         NA         NA       NA    
## ASV2925             NA         NA         NA       NA    
## ASV0618             NA         NA         NA       NA    
## ASV2083      2.631e+33  7.032e+36  0.000e+00    1.000    
## ASV6192             NA         NA         NA       NA    
## ASV8640             NA         NA         NA       NA    
## ASV1103             NA         NA         NA       NA    
## ASV4240             NA         NA         NA       NA    
## ASV2180             NA         NA         NA       NA    
## ASV9157             NA         NA         NA       NA    
## ASV1307             NA         NA         NA       NA    
## ASV4960             NA         NA         NA       NA    
## ASV3930             NA         NA         NA       NA    
## ASV1200             NA         NA         NA       NA    
## ASV4676             NA         NA         NA       NA    
## ASV6993             NA         NA         NA       NA    
## ASV4813             NA         NA         NA       NA    
## ASV4364             NA         NA         NA       NA    
## ASV0141             NA         NA         NA       NA    
## ASV3509             NA         NA         NA       NA    
## ASV2751             NA         NA         NA       NA    
## ASV4913             NA         NA         NA       NA    
## ASV0138             NA         NA         NA       NA    
## ASV7697             NA         NA         NA       NA    
## ASV1602             NA         NA         NA       NA    
## ASV5976             NA         NA         NA       NA    
## ASV7525             NA         NA         NA       NA    
## ASV4961             NA         NA         NA       NA    
## ASV2546             NA         NA         NA       NA    
## ASV0721             NA         NA         NA       NA    
## ASV0542             NA         NA         NA       NA    
## ASV3865             NA         NA         NA       NA    
## ASV5571             NA         NA         NA       NA    
## ASV6804             NA         NA         NA       NA    
## ASV4424             NA         NA         NA       NA    
## ASV3395             NA         NA         NA       NA    
## ASV2394             NA         NA         NA       NA    
## ASV8629             NA         NA         NA       NA    
## ASV1018             NA         NA         NA       NA    
## ASV6139             NA         NA         NA       NA    
## ASV10411            NA         NA         NA       NA    
## ASV3992             NA         NA         NA       NA    
## ASV7131             NA         NA         NA       NA    
## ASV3729      2.053e+33  5.986e+36  0.000e+00    1.000    
## ASV2197             NA         NA         NA       NA    
## ASV2426             NA         NA         NA       NA    
## ASV3669             NA         NA         NA       NA    
## ASV1820             NA         NA         NA       NA    
## ASV7081             NA         NA         NA       NA    
## ASV7872             NA         NA         NA       NA    
## ASV1670             NA         NA         NA       NA    
## ASV0712             NA         NA         NA       NA    
## ASV0474             NA         NA         NA       NA    
## ASV1196             NA         NA         NA       NA    
## ASV0845             NA         NA         NA       NA    
## ASV12393            NA         NA         NA       NA    
## ASV5867             NA         NA         NA       NA    
## ASV17619            NA         NA         NA       NA    
## ASV4686             NA         NA         NA       NA    
## ASV3520             NA         NA         NA       NA    
## ASV10800            NA         NA         NA       NA    
## ASV2706             NA         NA         NA       NA    
## ASV1227             NA         NA         NA       NA    
## ASV2621             NA         NA         NA       NA    
## ASV0460             NA         NA         NA       NA    
## ASV1069             NA         NA         NA       NA    
## ASV6939             NA         NA         NA       NA    
## ASV2862             NA         NA         NA       NA    
## ASV1021             NA         NA         NA       NA    
## ASV3845             NA         NA         NA       NA    
## ASV0732             NA         NA         NA       NA    
## ASV10731            NA         NA         NA       NA    
## ASV3378             NA         NA         NA       NA    
## ASV7154             NA         NA         NA       NA    
## ASV9876             NA         NA         NA       NA    
## ASV0631             NA         NA         NA       NA    
## ASV13027            NA         NA         NA       NA    
## ASV2497             NA         NA         NA       NA    
## ASV3966             NA         NA         NA       NA    
## ASV2574             NA         NA         NA       NA    
## ASV0545             NA         NA         NA       NA    
## ASV8453             NA         NA         NA       NA    
## ASV0221             NA         NA         NA       NA    
## ASV3305             NA         NA         NA       NA    
## ASV2647             NA         NA         NA       NA    
## ASV5789             NA         NA         NA       NA    
## ASV1731             NA         NA         NA       NA    
## ASV3857             NA         NA         NA       NA    
## ASV0405             NA         NA         NA       NA    
## ASV0094             NA         NA         NA       NA    
## ASV0158             NA         NA         NA       NA    
## ASV5507             NA         NA         NA       NA    
## ASV1023             NA         NA         NA       NA    
## ASV0488             NA         NA         NA       NA    
## ASV1459             NA         NA         NA       NA    
## ASV4349             NA         NA         NA       NA    
## ASV1172             NA         NA         NA       NA    
## ASV10187            NA         NA         NA       NA    
## ASV7227             NA         NA         NA       NA    
## ASV10340            NA         NA         NA       NA    
## ASV10821            NA         NA         NA       NA    
## ASV13810            NA         NA         NA       NA    
## ASV3230             NA         NA         NA       NA    
## ASV5524             NA         NA         NA       NA    
## ASV8742             NA         NA         NA       NA    
## ASV9188             NA         NA         NA       NA    
## ASV4658             NA         NA         NA       NA    
## ASV7889             NA         NA         NA       NA    
## ASV1466             NA         NA         NA       NA    
## ASV1424             NA         NA         NA       NA    
## ASV0098             NA         NA         NA       NA    
## ASV0067             NA         NA         NA       NA    
## ASV9434             NA         NA         NA       NA    
## ASV3270             NA         NA         NA       NA    
## ASV4518             NA         NA         NA       NA    
## ASV7661             NA         NA         NA       NA    
## ASV4223             NA         NA         NA       NA    
## ASV3481             NA         NA         NA       NA    
## ASV7819             NA         NA         NA       NA    
## ASV3095             NA         NA         NA       NA    
## ASV4476             NA         NA         NA       NA    
## ASV1713             NA         NA         NA       NA    
## ASV11165            NA         NA         NA       NA    
## ASV2179             NA         NA         NA       NA    
## ASV3747      3.623e+32  7.290e+36  0.000e+00    1.000    
## ASV1410             NA         NA         NA       NA    
## ASV6069             NA         NA         NA       NA    
## ASV1939             NA         NA         NA       NA    
## ASV7865             NA         NA         NA       NA    
## ASV4488             NA         NA         NA       NA    
## ASV0938             NA         NA         NA       NA    
## ASV7852             NA         NA         NA       NA    
## ASV2503             NA         NA         NA       NA    
## ASV2993             NA         NA         NA       NA    
## ASV3752             NA         NA         NA       NA    
## ASV2557             NA         NA         NA       NA    
## ASV6522             NA         NA         NA       NA    
## ASV0088             NA         NA         NA       NA    
## ASV7935             NA         NA         NA       NA    
## ASV0942             NA         NA         NA       NA    
## ASV7709             NA         NA         NA       NA    
## ASV4588             NA         NA         NA       NA    
## ASV5765             NA         NA         NA       NA    
## ASV3562             NA         NA         NA       NA    
## ASV9076             NA         NA         NA       NA    
## ASV4707             NA         NA         NA       NA    
## ASV2188             NA         NA         NA       NA    
## ASV0613             NA         NA         NA       NA    
## ASV0663             NA         NA         NA       NA    
## ASV3361             NA         NA         NA       NA    
## ASV1478             NA         NA         NA       NA    
## ASV0213             NA         NA         NA       NA    
## ASV7674             NA         NA         NA       NA    
## ASV2137     -3.418e+32  6.469e+35 -1.000e-03    1.000    
## ASV8246             NA         NA         NA       NA    
## ASV0047             NA         NA         NA       NA    
## ASV6117             NA         NA         NA       NA    
## ASV3349             NA         NA         NA       NA    
## ASV10881            NA         NA         NA       NA    
## ASV6979             NA         NA         NA       NA    
## ASV7930             NA         NA         NA       NA    
## ASV7322             NA         NA         NA       NA    
## ASV4927             NA         NA         NA       NA    
## ASV9054             NA         NA         NA       NA    
## ASV2692             NA         NA         NA       NA    
## ASV1666             NA         NA         NA       NA    
## ASV4728             NA         NA         NA       NA    
## ASV3097             NA         NA         NA       NA    
## ASV4962             NA         NA         NA       NA    
## ASV5057             NA         NA         NA       NA    
## ASV2639             NA         NA         NA       NA    
## ASV1808             NA         NA         NA       NA    
## ASV6333             NA         NA         NA       NA    
## ASV4328             NA         NA         NA       NA    
## ASV7707             NA         NA         NA       NA    
## ASV11022            NA         NA         NA       NA    
## ASV1469             NA         NA         NA       NA    
## ASV3919             NA         NA         NA       NA    
## ASV4038             NA         NA         NA       NA    
## ASV4048             NA         NA         NA       NA    
## ASV0634             NA         NA         NA       NA    
## ASV1852             NA         NA         NA       NA    
## ASV2505             NA         NA         NA       NA    
## ASV1762             NA         NA         NA       NA    
## ASV3761             NA         NA         NA       NA    
## ASV0775             NA         NA         NA       NA    
## ASV10911            NA         NA         NA       NA    
## ASV1339             NA         NA         NA       NA    
## ASV5214             NA         NA         NA       NA    
## ASV4945             NA         NA         NA       NA    
## ASV5624             NA         NA         NA       NA    
## ASV3429             NA         NA         NA       NA    
## ASV8416             NA         NA         NA       NA    
## ASV2400             NA         NA         NA       NA    
## ASV3388             NA         NA         NA       NA    
## ASV7089             NA         NA         NA       NA    
## ASV3396             NA         NA         NA       NA    
## ASV0343             NA         NA         NA       NA    
## ASV5505             NA         NA         NA       NA    
## ASV6721             NA         NA         NA       NA    
## ASV0537     -6.942e+32  1.508e+36  0.000e+00    1.000    
## ASV7753             NA         NA         NA       NA    
## ASV5022             NA         NA         NA       NA    
## ASV1073             NA         NA         NA       NA    
## ASV1347             NA         NA         NA       NA    
## ASV15032            NA         NA         NA       NA    
## ASV18213            NA         NA         NA       NA    
## ASV20691            NA         NA         NA       NA    
## ASV4260             NA         NA         NA       NA    
## ASV4923             NA         NA         NA       NA    
## ASV7995             NA         NA         NA       NA    
## ASV8960             NA         NA         NA       NA    
## ASV10682            NA         NA         NA       NA    
## ASV11911            NA         NA         NA       NA    
## ASV14296            NA         NA         NA       NA    
## ASV2314             NA         NA         NA       NA    
## ASV3819             NA         NA         NA       NA    
## ASV4517             NA         NA         NA       NA    
## ASV8941             NA         NA         NA       NA    
## ASV1444             NA         NA         NA       NA    
## ASV5959             NA         NA         NA       NA    
## ASV3623             NA         NA         NA       NA    
## ASV0260             NA         NA         NA       NA    
## ASV4401             NA         NA         NA       NA    
## ASV2891             NA         NA         NA       NA    
## ASV2778             NA         NA         NA       NA    
## ASV8744             NA         NA         NA       NA    
## ASV1079             NA         NA         NA       NA    
## ASV19688            NA         NA         NA       NA    
## ASV4039      8.792e+32  1.892e+36  0.000e+00    1.000    
## ASV4982             NA         NA         NA       NA    
## ASV1071             NA         NA         NA       NA    
## ASV7666             NA         NA         NA       NA    
## ASV0502             NA         NA         NA       NA    
## ASV3624             NA         NA         NA       NA    
## ASV0403      1.420e+32  4.705e+36  0.000e+00    1.000    
## ASV4939             NA         NA         NA       NA    
## ASV6297             NA         NA         NA       NA    
## ASV6343             NA         NA         NA       NA    
## ASV0954             NA         NA         NA       NA    
## ASV10225            NA         NA         NA       NA    
## ASV1584             NA         NA         NA       NA    
## ASV1803             NA         NA         NA       NA    
## ASV2576             NA         NA         NA       NA    
## ASV3252             NA         NA         NA       NA    
## ASV3463             NA         NA         NA       NA    
## ASV3822             NA         NA         NA       NA    
## ASV4926             NA         NA         NA       NA    
## ASV5564             NA         NA         NA       NA    
## ASV5595             NA         NA         NA       NA    
## ASV16463            NA         NA         NA       NA    
## ASV6277             NA         NA         NA       NA    
## ASV1344             NA         NA         NA       NA    
## ASV1869             NA         NA         NA       NA    
## ASV8155             NA         NA         NA       NA    
## ASV2502             NA         NA         NA       NA    
## ASV6742             NA         NA         NA       NA    
## ASV3124             NA         NA         NA       NA    
## ASV17042            NA         NA         NA       NA    
## ASV0248             NA         NA         NA       NA    
## ASV4557             NA         NA         NA       NA    
## ASV3507             NA         NA         NA       NA    
## ASV1870             NA         NA         NA       NA    
## ASV2447             NA         NA         NA       NA    
## ASV0347             NA         NA         NA       NA    
## ASV1855             NA         NA         NA       NA    
## ASV0568             NA         NA         NA       NA    
## ASV1620             NA         NA         NA       NA    
## ASV0101             NA         NA         NA       NA    
## ASV7751             NA         NA         NA       NA    
## ASV9033             NA         NA         NA       NA    
## ASV3438             NA         NA         NA       NA    
## ASV0637             NA         NA         NA       NA    
## ASV1181             NA         NA         NA       NA    
## ASV13480            NA         NA         NA       NA    
## ASV14220            NA         NA         NA       NA    
## ASV1448             NA         NA         NA       NA    
## ASV1457             NA         NA         NA       NA    
## ASV1645             NA         NA         NA       NA    
## ASV2300             NA         NA         NA       NA    
## ASV2533             NA         NA         NA       NA    
## ASV5059             NA         NA         NA       NA    
## ASV8871             NA         NA         NA       NA    
## ASV1289             NA         NA         NA       NA    
## ASV3983             NA         NA         NA       NA    
## ASV10323            NA         NA         NA       NA    
## ASV13279            NA         NA         NA       NA    
## ASV7149             NA         NA         NA       NA    
## ASV1691             NA         NA         NA       NA    
## ASV1649             NA         NA         NA       NA    
## ASV10120     1.943e+33  1.290e+36  2.000e-03    0.999    
## ASV8285             NA         NA         NA       NA    
## ASV0037             NA         NA         NA       NA    
## ASV1770             NA         NA         NA       NA    
## ASV2252             NA         NA         NA       NA    
## ASV7580             NA         NA         NA       NA    
## ASV5643             NA         NA         NA       NA    
## ASV2722             NA         NA         NA       NA    
## ASV2662             NA         NA         NA       NA    
## ASV0479             NA         NA         NA       NA    
## ASV2009             NA         NA         NA       NA    
## ASV3731             NA         NA         NA       NA    
## ASV5497             NA         NA         NA       NA    
## ASV6647             NA         NA         NA       NA    
## ASV8974             NA         NA         NA       NA    
## ASV15527            NA         NA         NA       NA    
## ASV6705      3.039e+33  9.068e+36  0.000e+00    1.000    
## ASV0354             NA         NA         NA       NA    
## ASV2707             NA         NA         NA       NA    
## ASV11167            NA         NA         NA       NA    
## ASV6393             NA         NA         NA       NA    
## ASV3808             NA         NA         NA       NA    
## ASV9337             NA         NA         NA       NA    
## ASV5043      3.768e+32  1.984e+36  0.000e+00    1.000    
## ASV4189             NA         NA         NA       NA    
## ASV1304             NA         NA         NA       NA    
## ASV2105             NA         NA         NA       NA    
## ASV2421             NA         NA         NA       NA    
## ASV3170             NA         NA         NA       NA    
## ASV5036             NA         NA         NA       NA    
## ASV2286             NA         NA         NA       NA    
## ASV3363             NA         NA         NA       NA    
## ASV5759             NA         NA         NA       NA    
## ASV5440             NA         NA         NA       NA    
## ASV2050             NA         NA         NA       NA    
## ASV4478             NA         NA         NA       NA    
## ASV5725             NA         NA         NA       NA    
## ASV1600             NA         NA         NA       NA    
## ASV1654             NA         NA         NA       NA    
## ASV3781             NA         NA         NA       NA    
## ASV7144             NA         NA         NA       NA    
## ASV12710            NA         NA         NA       NA    
## ASV3317             NA         NA         NA       NA    
## ASV3249             NA         NA         NA       NA    
## ASV0669             NA         NA         NA       NA    
## ASV0893             NA         NA         NA       NA    
## ASV11060            NA         NA         NA       NA    
## ASV3207             NA         NA         NA       NA    
## ASV3498             NA         NA         NA       NA    
## ASV4358             NA         NA         NA       NA    
## ASV4806             NA         NA         NA       NA    
## ASV4941             NA         NA         NA       NA    
## ASV6998             NA         NA         NA       NA    
## ASV7327             NA         NA         NA       NA    
## ASV5112             NA         NA         NA       NA    
## ASV5345             NA         NA         NA       NA    
## ASV8911             NA         NA         NA       NA    
## ASV5061             NA         NA         NA       NA    
## ASV1968             NA         NA         NA       NA    
## ASV4669             NA         NA         NA       NA    
## ASV6209             NA         NA         NA       NA    
## ASV6938             NA         NA         NA       NA    
## ASV6987             NA         NA         NA       NA    
## ASV7842             NA         NA         NA       NA    
## ASV17950            NA         NA         NA       NA    
## ASV3380             NA         NA         NA       NA    
## ASV13740            NA         NA         NA       NA    
## ASV4313             NA         NA         NA       NA    
## ASV3891             NA         NA         NA       NA    
## ASV3322      1.794e+33  2.673e+36  1.000e-03    0.999    
## ASV1668             NA         NA         NA       NA    
## ASV1739             NA         NA         NA       NA    
## ASV3194             NA         NA         NA       NA    
## ASV0071             NA         NA         NA       NA    
## ASV0695             NA         NA         NA       NA    
## ASV3835             NA         NA         NA       NA    
## ASV1876             NA         NA         NA       NA    
## ASV4892             NA         NA         NA       NA    
## ASV1212             NA         NA         NA       NA    
## ASV2640             NA         NA         NA       NA    
## ASV7236             NA         NA         NA       NA    
## ASV2353             NA         NA         NA       NA    
## ASV0276             NA         NA         NA       NA    
## ASV2262             NA         NA         NA       NA    
## ASV11201            NA         NA         NA       NA    
## ASV0665             NA         NA         NA       NA    
## ASV5238             NA         NA         NA       NA    
## ASV6885             NA         NA         NA       NA    
## ASV1844             NA         NA         NA       NA    
## ASV0379             NA         NA         NA       NA    
## ASV1040             NA         NA         NA       NA    
## ASV7913             NA         NA         NA       NA    
## ASV1197             NA         NA         NA       NA    
## ASV5918             NA         NA         NA       NA    
## ASV8045             NA         NA         NA       NA    
## ASV16458            NA         NA         NA       NA    
## ASV10827            NA         NA         NA       NA    
## ASV3658             NA         NA         NA       NA    
## ASV0073             NA         NA         NA       NA    
## ASV1951             NA         NA         NA       NA    
## ASV7630             NA         NA         NA       NA    
## ASV9449             NA         NA         NA       NA    
## ASV3944     -1.164e+33  5.862e+36  0.000e+00    1.000    
## ASV1520             NA         NA         NA       NA    
## ASV0307             NA         NA         NA       NA    
## ASV12731            NA         NA         NA       NA    
## ASV0282             NA         NA         NA       NA    
## ASV2646             NA         NA         NA       NA    
## ASV3536             NA         NA         NA       NA    
## ASV10089            NA         NA         NA       NA    
## ASV1185             NA         NA         NA       NA    
## ASV1452             NA         NA         NA       NA    
## ASV1700             NA         NA         NA       NA    
## ASV6948             NA         NA         NA       NA    
## ASV0389             NA         NA         NA       NA    
## ASV11884            NA         NA         NA       NA    
## ASV23165            NA         NA         NA       NA    
## ASV2841             NA         NA         NA       NA    
## ASV2949             NA         NA         NA       NA    
## ASV4037             NA         NA         NA       NA    
## ASV4477             NA         NA         NA       NA    
## ASV4496             NA         NA         NA       NA    
## ASV5784             NA         NA         NA       NA    
## ASV6035             NA         NA         NA       NA    
## ASV6232             NA         NA         NA       NA    
## ASV1818             NA         NA         NA       NA    
## ASV2595             NA         NA         NA       NA    
## ASV2788             NA         NA         NA       NA    
## ASV5018             NA         NA         NA       NA    
## ASV0127             NA         NA         NA       NA    
## ASV1527             NA         NA         NA       NA    
## ASV1055             NA         NA         NA       NA    
## ASV4791             NA         NA         NA       NA    
## ASV0859             NA         NA         NA       NA    
## ASV12971            NA         NA         NA       NA    
## ASV16856            NA         NA         NA       NA    
## ASV7321             NA         NA         NA       NA    
## ASV8780             NA         NA         NA       NA    
## ASV1569             NA         NA         NA       NA    
## ASV3696             NA         NA         NA       NA    
## ASV0624             NA         NA         NA       NA    
## ASV0495             NA         NA         NA       NA    
## ASV16971            NA         NA         NA       NA    
## ASV6535             NA         NA         NA       NA    
## ASV1897             NA         NA         NA       NA    
## ASV2631             NA         NA         NA       NA    
## ASV6204             NA         NA         NA       NA    
## ASV3312             NA         NA         NA       NA    
## ASV3360             NA         NA         NA       NA    
## ASV3907             NA         NA         NA       NA    
## ASV6090             NA         NA         NA       NA    
## ASV8652             NA         NA         NA       NA    
## ASV11129            NA         NA         NA       NA    
## ASV11073            NA         NA         NA       NA    
## ASV1840             NA         NA         NA       NA    
## ASV2298             NA         NA         NA       NA    
## ASV2420             NA         NA         NA       NA    
## ASV6474             NA         NA         NA       NA    
## ASV8475             NA         NA         NA       NA    
## ASV8679             NA         NA         NA       NA    
## ASV6527             NA         NA         NA       NA    
## ASV2504             NA         NA         NA       NA    
## ASV1093             NA         NA         NA       NA    
## ASV0994             NA         NA         NA       NA    
## ASV0092             NA         NA         NA       NA    
## ASV2619             NA         NA         NA       NA    
## ASV0121             NA         NA         NA       NA    
## ASV0932             NA         NA         NA       NA    
## ASV5229             NA         NA         NA       NA    
## ASV6737             NA         NA         NA       NA    
## ASV11213            NA         NA         NA       NA    
## ASV1151             NA         NA         NA       NA    
## ASV3813             NA         NA         NA       NA    
## ASV5566             NA         NA         NA       NA    
## ASV7529             NA         NA         NA       NA    
## ASV2193             NA         NA         NA       NA    
## ASV2349             NA         NA         NA       NA    
## ASV2387             NA         NA         NA       NA    
## ASV2699             NA         NA         NA       NA    
## ASV3353             NA         NA         NA       NA    
## ASV3621             NA         NA         NA       NA    
## ASV3848             NA         NA         NA       NA    
## ASV4440             NA         NA         NA       NA    
## ASV4751             NA         NA         NA       NA    
## ASV5115             NA         NA         NA       NA    
## ASV5850             NA         NA         NA       NA    
## ASV6293             NA         NA         NA       NA    
## ASV6513             NA         NA         NA       NA    
## ASV7628             NA         NA         NA       NA    
## ASV7658             NA         NA         NA       NA    
## ASV0776             NA         NA         NA       NA    
## ASV10227            NA         NA         NA       NA    
## ASV11965            NA         NA         NA       NA    
## ASV1270             NA         NA         NA       NA    
## ASV13123            NA         NA         NA       NA    
## ASV5828             NA         NA         NA       NA    
## ASV5920             NA         NA         NA       NA    
## ASV6071             NA         NA         NA       NA    
## ASV6723             NA         NA         NA       NA    
## ASV6727             NA         NA         NA       NA    
## ASV7759             NA         NA         NA       NA    
## ASV0733             NA         NA         NA       NA    
## ASV1655             NA         NA         NA       NA    
## ASV0755             NA         NA         NA       NA    
## ASV0796             NA         NA         NA       NA    
## ASV0878             NA         NA         NA       NA    
## ASV4988             NA         NA         NA       NA    
## ASV0083             NA         NA         NA       NA    
## ASV0273             NA         NA         NA       NA    
## ASV3076             NA         NA         NA       NA    
## ASV1513             NA         NA         NA       NA    
## ASV5159             NA         NA         NA       NA    
## ASV3422             NA         NA         NA       NA    
## ASV12230            NA         NA         NA       NA    
## ASV1694             NA         NA         NA       NA    
## ASV1249             NA         NA         NA       NA    
## ASV1697             NA         NA         NA       NA    
## ASV4408             NA         NA         NA       NA    
## ASV0095      4.185e+33  2.057e+37  0.000e+00    1.000    
## ASV0410             NA         NA         NA       NA    
## ASV4642             NA         NA         NA       NA    
## ASV4560             NA         NA         NA       NA    
## ASV7586      1.563e+33  7.193e+36  0.000e+00    1.000    
## ASV4144             NA         NA         NA       NA    
## ASV0327             NA         NA         NA       NA    
## ASV0946             NA         NA         NA       NA    
## ASV3254             NA         NA         NA       NA    
## ASV0349             NA         NA         NA       NA    
## ASV0472             NA         NA         NA       NA    
## ASV1330             NA         NA         NA       NA    
## ASV2605             NA         NA         NA       NA    
## ASV2846             NA         NA         NA       NA    
## ASV3982             NA         NA         NA       NA    
## ASV4116             NA         NA         NA       NA    
## ASV6048             NA         NA         NA       NA    
## ASV1146             NA         NA         NA       NA    
## ASV13362            NA         NA         NA       NA    
## ASV1422             NA         NA         NA       NA    
## ASV3640             NA         NA         NA       NA    
## ASV5404             NA         NA         NA       NA    
## ASV6118             NA         NA         NA       NA    
## ASV1115             NA         NA         NA       NA    
## ASV0888             NA         NA         NA       NA    
## ASV4620             NA         NA         NA       NA    
## ASV3099             NA         NA         NA       NA    
## ASV7099             NA         NA         NA       NA    
## ASV5892             NA         NA         NA       NA    
## ASV6978             NA         NA         NA       NA    
## ASV6555             NA         NA         NA       NA    
## ASV0539             NA         NA         NA       NA    
## ASV4665             NA         NA         NA       NA    
## ASV2210             NA         NA         NA       NA    
## ASV1329             NA         NA         NA       NA    
## ASV7123             NA         NA         NA       NA    
## ASV1260             NA         NA         NA       NA    
## ASV1011             NA         NA         NA       NA    
## ASV4233      2.550e+33  1.286e+37  0.000e+00    1.000    
## ASV1475             NA         NA         NA       NA    
## ASV6099             NA         NA         NA       NA    
## ASV1428             NA         NA         NA       NA    
## ASV5101             NA         NA         NA       NA    
## ASV11827            NA         NA         NA       NA    
## ASV13899            NA         NA         NA       NA    
## ASV21259            NA         NA         NA       NA    
## ASV6635             NA         NA         NA       NA    
## ASV9922             NA         NA         NA       NA    
## ASV2869             NA         NA         NA       NA    
## ASV1740             NA         NA         NA       NA    
## ASV4406             NA         NA         NA       NA    
## ASV5586             NA         NA         NA       NA    
## ASV3255             NA         NA         NA       NA    
## ASV12281            NA         NA         NA       NA    
## ASV5388             NA         NA         NA       NA    
## ASV17660            NA         NA         NA       NA    
## ASV0159             NA         NA         NA       NA    
## ASV2734             NA         NA         NA       NA    
## ASV2049             NA         NA         NA       NA    
## ASV2465             NA         NA         NA       NA    
## ASV2147             NA         NA         NA       NA    
## ASV3113             NA         NA         NA       NA    
## ASV0622             NA         NA         NA       NA    
## ASV0437             NA         NA         NA       NA    
## ASV6385             NA         NA         NA       NA    
## ASV3699      3.631e+33  1.523e+37  0.000e+00    1.000    
## ASV2208      5.399e+33  1.989e+37  0.000e+00    1.000    
## ASV1053             NA         NA         NA       NA    
## ASV8468             NA         NA         NA       NA    
## ASV0951             NA         NA         NA       NA    
## ASV0278             NA         NA         NA       NA    
## ASV0914             NA         NA         NA       NA    
## ASV0737             NA         NA         NA       NA    
## ASV2038             NA         NA         NA       NA    
## ASV2171             NA         NA         NA       NA    
## ASV2607             NA         NA         NA       NA    
## ASV3143             NA         NA         NA       NA    
## ASV3187             NA         NA         NA       NA    
## ASV3810             NA         NA         NA       NA    
## ASV5060             NA         NA         NA       NA    
## ASV5325             NA         NA         NA       NA    
## ASV6905             NA         NA         NA       NA    
## ASV7597             NA         NA         NA       NA    
## ASV9652             NA         NA         NA       NA    
## ASV2634             NA         NA         NA       NA    
## ASV3065             NA         NA         NA       NA    
## ASV3331             NA         NA         NA       NA    
## ASV7434             NA         NA         NA       NA    
## ASV7720             NA         NA         NA       NA    
## ASV8414             NA         NA         NA       NA    
## ASV12139            NA         NA         NA       NA    
## ASV1824             NA         NA         NA       NA    
## ASV2094             NA         NA         NA       NA    
## ASV2770             NA         NA         NA       NA    
## ASV3505             NA         NA         NA       NA    
## ASV1935             NA         NA         NA       NA    
## ASV5764             NA         NA         NA       NA    
## ASV6806             NA         NA         NA       NA    
## ASV6942             NA         NA         NA       NA    
## ASV1166             NA         NA         NA       NA    
## ASV1664             NA         NA         NA       NA    
## ASV2568             NA         NA         NA       NA    
## ASV3525             NA         NA         NA       NA    
## ASV4965             NA         NA         NA       NA    
## ASV6607             NA         NA         NA       NA    
## ASV7187             NA         NA         NA       NA    
## ASV0388             NA         NA         NA       NA    
## ASV1420             NA         NA         NA       NA    
## ASV14293            NA         NA         NA       NA    
## ASV17785            NA         NA         NA       NA    
## ASV7678             NA         NA         NA       NA    
## ASV2253             NA         NA         NA       NA    
## ASV4150             NA         NA         NA       NA    
## ASV3836             NA         NA         NA       NA    
## ASV16231            NA         NA         NA       NA    
## ASV2730             NA         NA         NA       NA    
## ASV2072             NA         NA         NA       NA    
## ASV2160             NA         NA         NA       NA    
## ASV5013             NA         NA         NA       NA    
## ASV2586             NA         NA         NA       NA    
## ASV1442             NA         NA         NA       NA    
## ASV3101             NA         NA         NA       NA    
## ASV3323             NA         NA         NA       NA    
## ASV1812             NA         NA         NA       NA    
## ASV6120             NA         NA         NA       NA    
## ASV2565             NA         NA         NA       NA    
## ASV6687             NA         NA         NA       NA    
## ASV5357             NA         NA         NA       NA    
## ASV9383             NA         NA         NA       NA    
## ASV11753            NA         NA         NA       NA    
## ASV11512            NA         NA         NA       NA    
## ASV2791             NA         NA         NA       NA    
## ASV0664             NA         NA         NA       NA    
## ASV3436             NA         NA         NA       NA    
## ASV5755             NA         NA         NA       NA    
## ASV10970            NA         NA         NA       NA    
## ASV11798            NA         NA         NA       NA    
## ASV18193            NA         NA         NA       NA    
## ASV2548             NA         NA         NA       NA    
## ASV3901             NA         NA         NA       NA    
## ASV5197             NA         NA         NA       NA    
## ASV5859             NA         NA         NA       NA    
## ASV6240             NA         NA         NA       NA    
## ASV7281             NA         NA         NA       NA    
## ASV7635             NA         NA         NA       NA    
## ASV8822             NA         NA         NA       NA    
## ASV4810             NA         NA         NA       NA    
## ASV5308             NA         NA         NA       NA    
## ASV2749             NA         NA         NA       NA    
## ASV0298             NA         NA         NA       NA    
## ASV2597             NA         NA         NA       NA    
## ASV5758             NA         NA         NA       NA    
## ASV9987             NA         NA         NA       NA    
## ASV0971             NA         NA         NA       NA    
## ASV0627             NA         NA         NA       NA    
## ASV1758             NA         NA         NA       NA    
## ASV4559             NA         NA         NA       NA    
## ASV11400            NA         NA         NA       NA    
## ASV11559            NA         NA         NA       NA    
## ASV3943             NA         NA         NA       NA    
## ASV10389            NA         NA         NA       NA    
## ASV5168             NA         NA         NA       NA    
## ASV5724             NA         NA         NA       NA    
## ASV6337             NA         NA         NA       NA    
## ASV11063            NA         NA         NA       NA    
## ASV4279             NA         NA         NA       NA    
## ASV7660             NA         NA         NA       NA    
## ASV8218             NA         NA         NA       NA    
## ASV3574             NA         NA         NA       NA    
## ASV12050            NA         NA         NA       NA    
## ASV3897             NA         NA         NA       NA    
## ASV3856             NA         NA         NA       NA    
## ASV3024             NA         NA         NA       NA    
## ASV8715             NA         NA         NA       NA    
## ASV6917             NA         NA         NA       NA    
## ASV1132             NA         NA         NA       NA    
## ASV3583             NA         NA         NA       NA    
## ASV0328             NA         NA         NA       NA    
## ASV0915             NA         NA         NA       NA    
## ASV2677             NA         NA         NA       NA    
## ASV0599             NA         NA         NA       NA    
## ASV0283             NA         NA         NA       NA    
## ASV1028             NA         NA         NA       NA    
## ASV0523             NA         NA         NA       NA    
## ASV8201             NA         NA         NA       NA    
## ASV2795             NA         NA         NA       NA    
## ASV3563             NA         NA         NA       NA    
## ASV1553             NA         NA         NA       NA    
## ASV7155             NA         NA         NA       NA    
## ASV0365             NA         NA         NA       NA    
## ASV8583             NA         NA         NA       NA    
## ASV5400             NA         NA         NA       NA    
## ASV5908             NA         NA         NA       NA    
## ASV2075             NA         NA         NA       NA    
## ASV2520             NA         NA         NA       NA    
## ASV9596             NA         NA         NA       NA    
## ASV1131             NA         NA         NA       NA    
## ASV0579             NA         NA         NA       NA    
## ASV0288             NA         NA         NA       NA    
## ASV4053             NA         NA         NA       NA    
## ASV1736             NA         NA         NA       NA    
## ASV1254             NA         NA         NA       NA    
## ASV9038             NA         NA         NA       NA    
## ASV4746             NA         NA         NA       NA    
## ASV5803             NA         NA         NA       NA    
## ASV0525             NA         NA         NA       NA    
## ASV1974             NA         NA         NA       NA    
## ASV1827             NA         NA         NA       NA    
## ASV30780            NA         NA         NA       NA    
## ASV9342             NA         NA         NA       NA    
## ASV21626            NA         NA         NA       NA    
## ASV1232             NA         NA         NA       NA    
## ASV5578             NA         NA         NA       NA    
## ASV5868             NA         NA         NA       NA    
## ASV13625            NA         NA         NA       NA    
## ASV3614             NA         NA         NA       NA    
## ASV2128             NA         NA         NA       NA    
## ASV5086             NA         NA         NA       NA    
## ASV6614             NA         NA         NA       NA    
## ASV9451             NA         NA         NA       NA    
## ASV9533             NA         NA         NA       NA    
## ASV10697            NA         NA         NA       NA    
## ASV1473             NA         NA         NA       NA    
## ASV1414             NA         NA         NA       NA    
## ASV1567             NA         NA         NA       NA    
## ASV6395             NA         NA         NA       NA    
## ASV2366             NA         NA         NA       NA    
## ASV2537             NA         NA         NA       NA    
## ASV5378             NA         NA         NA       NA    
## ASV5929             NA         NA         NA       NA    
## ASV6360             NA         NA         NA       NA    
## ASV7916             NA         NA         NA       NA    
## ASV13322            NA         NA         NA       NA    
## ASV6207             NA         NA         NA       NA    
## ASV8823             NA         NA         NA       NA    
## ASV1379             NA         NA         NA       NA    
## ASV3259             NA         NA         NA       NA    
## ASV18748            NA         NA         NA       NA    
## ASV3570             NA         NA         NA       NA    
## ASV0790             NA         NA         NA       NA    
## ASV5149             NA         NA         NA       NA    
## ASV1730             NA         NA         NA       NA    
## ASV3488             NA         NA         NA       NA    
## ASV5486             NA         NA         NA       NA    
## ASV1319             NA         NA         NA       NA    
## ASV15328            NA         NA         NA       NA    
## ASV5994             NA         NA         NA       NA    
## ASV4992             NA         NA         NA       NA    
## ASV1788             NA         NA         NA       NA    
## ASV3264             NA         NA         NA       NA    
## ASV4895             NA         NA         NA       NA    
## ASV9218             NA         NA         NA       NA    
## ASV0736             NA         NA         NA       NA    
## ASV0916             NA         NA         NA       NA    
## ASV15761            NA         NA         NA       NA    
## ASV4191             NA         NA         NA       NA    
## ASV3268             NA         NA         NA       NA    
## ASV15321            NA         NA         NA       NA    
## ASV0708             NA         NA         NA       NA    
## ASV4100             NA         NA         NA       NA    
## ASV1627             NA         NA         NA       NA    
## ASV7045             NA         NA         NA       NA    
## ASV3271             NA         NA         NA       NA    
## ASV6200             NA         NA         NA       NA    
## ASV2727             NA         NA         NA       NA    
## ASV3523             NA         NA         NA       NA    
## ASV2259             NA         NA         NA       NA    
## ASV0181             NA         NA         NA       NA    
## ASV1680             NA         NA         NA       NA    
## ASV0176             NA         NA         NA       NA    
## ASV10458            NA         NA         NA       NA    
## ASV10658            NA         NA         NA       NA    
## ASV16807            NA         NA         NA       NA    
## ASV2113             NA         NA         NA       NA    
## ASV2403             NA         NA         NA       NA    
## ASV2484             NA         NA         NA       NA    
## ASV8876             NA         NA         NA       NA    
## ASV0386             NA         NA         NA       NA    
## ASV0351             NA         NA         NA       NA    
## ASV4942             NA         NA         NA       NA    
## ASV5128             NA         NA         NA       NA    
## ASV3496             NA         NA         NA       NA    
## ASV3329             NA         NA         NA       NA    
## ASV7878             NA         NA         NA       NA    
## ASV8251             NA         NA         NA       NA    
## ASV15958            NA         NA         NA       NA    
## ASV7972             NA         NA         NA       NA    
## ASV2088             NA         NA         NA       NA    
## ASV3054             NA         NA         NA       NA    
## ASV4494             NA         NA         NA       NA    
## ASV0087             NA         NA         NA       NA    
## ASV1614             NA         NA         NA       NA    
## ASV3037             NA         NA         NA       NA    
## ASV6615             NA         NA         NA       NA    
## ASV1027             NA         NA         NA       NA    
## ASV2754             NA         NA         NA       NA    
## ASV0536             NA         NA         NA       NA    
## ASV2318             NA         NA         NA       NA    
## ASV5954             NA         NA         NA       NA    
## ASV9028             NA         NA         NA       NA    
## ASV6600             NA         NA         NA       NA    
## ASV1923             NA         NA         NA       NA    
## ASV4034             NA         NA         NA       NA    
## ASV9933             NA         NA         NA       NA    
## ASV1575             NA         NA         NA       NA    
## ASV7812             NA         NA         NA       NA    
## ASV0515             NA         NA         NA       NA    
## ASV1149             NA         NA         NA       NA    
## ASV3791             NA         NA         NA       NA    
## ASV4065             NA         NA         NA       NA    
## ASV10631            NA         NA         NA       NA    
## ASV2359             NA         NA         NA       NA    
## ASV3206             NA         NA         NA       NA    
## ASV4415             NA         NA         NA       NA    
## ASV4467             NA         NA         NA       NA    
## ASV5598             NA         NA         NA       NA    
## ASV5910             NA         NA         NA       NA    
## ASV9494             NA         NA         NA       NA    
## ASV6548             NA         NA         NA       NA    
## ASV8669             NA         NA         NA       NA    
## ASV0674             NA         NA         NA       NA    
## ASV0061             NA         NA         NA       NA    
## ASV0310             NA         NA         NA       NA    
## ASV0582             NA         NA         NA       NA    
## ASV0739             NA         NA         NA       NA    
## ASV1557             NA         NA         NA       NA    
## ASV0146             NA         NA         NA       NA    
## ASV3832             NA         NA         NA       NA    
## ASV0734             NA         NA         NA       NA    
## ASV3036             NA         NA         NA       NA    
## ASV0240             NA         NA         NA       NA    
## ASV2513             NA         NA         NA       NA    
## ASV1118             NA         NA         NA       NA    
## ASV7286             NA         NA         NA       NA    
## ASV1077             NA         NA         NA       NA    
## ASV1255             NA         NA         NA       NA    
## ASV1794             NA         NA         NA       NA    
## ASV2439             NA         NA         NA       NA    
## ASV2467             NA         NA         NA       NA    
## ASV3346             NA         NA         NA       NA    
## ASV3973             NA         NA         NA       NA    
## ASV4521             NA         NA         NA       NA    
## ASV1909             NA         NA         NA       NA    
## ASV3855             NA         NA         NA       NA    
## ASV0810             NA         NA         NA       NA    
## ASV1765             NA         NA         NA       NA    
## ASV0763             NA         NA         NA       NA    
## ASV0302             NA         NA         NA       NA    
## ASV2643             NA         NA         NA       NA    
## ASV0440             NA         NA         NA       NA    
## ASV4899             NA         NA         NA       NA    
## ASV0287             NA         NA         NA       NA    
## ASV3220             NA         NA         NA       NA    
## ASV1007             NA         NA         NA       NA    
## ASV2929             NA         NA         NA       NA    
## ASV1496             NA         NA         NA       NA    
## ASV4975             NA         NA         NA       NA    
## ASV4392             NA         NA         NA       NA    
## ASV4653             NA         NA         NA       NA    
## ASV0230             NA         NA         NA       NA    
## ASV0840             NA         NA         NA       NA    
## ASV4132             NA         NA         NA       NA    
## ASV3344             NA         NA         NA       NA    
## ASV12096            NA         NA         NA       NA    
## ASV1550             NA         NA         NA       NA    
## ASV3542             NA         NA         NA       NA    
## ASV8795             NA         NA         NA       NA    
## ASV2532             NA         NA         NA       NA    
## ASV3087             NA         NA         NA       NA    
## ASV9476             NA         NA         NA       NA    
## ASV13721            NA         NA         NA       NA    
## ASV3842             NA         NA         NA       NA    
## ASV1663             NA         NA         NA       NA    
## ASV0432             NA         NA         NA       NA    
## ASV4356             NA         NA         NA       NA    
## ASV4524             NA         NA         NA       NA    
## ASV0169             NA         NA         NA       NA    
## ASV0368             NA         NA         NA       NA    
## ASV2603             NA         NA         NA       NA    
## ASV3777             NA         NA         NA       NA    
## ASV3978             NA         NA         NA       NA    
## ASV0413             NA         NA         NA       NA    
## ASV0997             NA         NA         NA       NA    
## ASV1195             NA         NA         NA       NA    
## ASV2522             NA         NA         NA       NA    
## ASV4733             NA         NA         NA       NA    
## ASV1063             NA         NA         NA       NA    
## ASV0612             NA         NA         NA       NA    
## ASV1903             NA         NA         NA       NA    
## ASV3576             NA         NA         NA       NA    
## ASV4285             NA         NA         NA       NA    
## ASV3406             NA         NA         NA       NA    
## ASV2379             NA         NA         NA       NA    
## ASV0528             NA         NA         NA       NA    
## ASV6190             NA         NA         NA       NA    
## ASV1537             NA         NA         NA       NA    
## ASV16780            NA         NA         NA       NA    
## ASV0477             NA         NA         NA       NA    
## ASV1499             NA         NA         NA       NA    
## ASV14736            NA         NA         NA       NA    
## ASV0179             NA         NA         NA       NA    
## ASV3153             NA         NA         NA       NA    
## ASV0266             NA         NA         NA       NA    
## ASV0761             NA         NA         NA       NA    
## ASV0269             NA         NA         NA       NA    
## ASV7259             NA         NA         NA       NA    
## ASV2067             NA         NA         NA       NA    
## ASV2985             NA         NA         NA       NA    
## ASV0975             NA         NA         NA       NA    
## ASV2240             NA         NA         NA       NA    
## ASV2297             NA         NA         NA       NA    
## ASV2657             NA         NA         NA       NA    
## ASV3784             NA         NA         NA       NA    
## ASV4333             NA         NA         NA       NA    
## ASV5547             NA         NA         NA       NA    
## ASV5813             NA         NA         NA       NA    
## ASV8049             NA         NA         NA       NA    
## ASV8661             NA         NA         NA       NA    
## ASV9510             NA         NA         NA       NA    
## ASV1401             NA         NA         NA       NA    
## ASV1417             NA         NA         NA       NA    
## ASV2169             NA         NA         NA       NA    
## ASV5354             NA         NA         NA       NA    
## ASV5379             NA         NA         NA       NA    
## ASV6078             NA         NA         NA       NA    
## ASV6417             NA         NA         NA       NA    
## ASV8304             NA         NA         NA       NA    
## ASV8766             NA         NA         NA       NA    
## ASV10861            NA         NA         NA       NA    
## ASV2057             NA         NA         NA       NA    
## ASV4499             NA         NA         NA       NA    
## ASV7415             NA         NA         NA       NA    
## ASV2475             NA         NA         NA       NA    
## ASV3517             NA         NA         NA       NA    
## ASV1864             NA         NA         NA       NA    
## ASV2756             NA         NA         NA       NA    
## ASV0778             NA         NA         NA       NA    
## ASV3201             NA         NA         NA       NA    
## ASV3358             NA         NA         NA       NA    
## ASV5681             NA         NA         NA       NA    
## ASV7256             NA         NA         NA       NA    
## ASV1704             NA         NA         NA       NA    
## ASV4445             NA         NA         NA       NA    
## ASV8649             NA         NA         NA       NA    
## ASV0597             NA         NA         NA       NA    
## ASV0861             NA         NA         NA       NA    
## ASV2423             NA         NA         NA       NA    
## ASV1548             NA         NA         NA       NA    
## ASV2564             NA         NA         NA       NA    
## ASV2999             NA         NA         NA       NA    
## ASV4543             NA         NA         NA       NA    
## ASV8452             NA         NA         NA       NA    
## ASV17287            NA         NA         NA       NA    
## ASV3503             NA         NA         NA       NA    
## ASV4727             NA         NA         NA       NA    
## ASV5995             NA         NA         NA       NA    
## ASV1665             NA         NA         NA       NA    
## ASV2690             NA         NA         NA       NA    
## ASV2823             NA         NA         NA       NA    
## ASV5241             NA         NA         NA       NA    
## ASV5473             NA         NA         NA       NA    
## ASV2785             NA         NA         NA       NA    
## ASV6645             NA         NA         NA       NA    
## ASV0562             NA         NA         NA       NA    
## ASV1163             NA         NA         NA       NA    
## ASV1825             NA         NA         NA       NA    
## ASV3795             NA         NA         NA       NA    
## ASV3869             NA         NA         NA       NA    
## ASV4330             NA         NA         NA       NA    
## ASV6754             NA         NA         NA       NA    
## ASV4598             NA         NA         NA       NA    
## ASV2100             NA         NA         NA       NA    
## ASV3518             NA         NA         NA       NA    
## ASV3823             NA         NA         NA       NA    
## ASV7357             NA         NA         NA       NA    
## ASV7403             NA         NA         NA       NA    
## ASV2934             NA         NA         NA       NA    
## ASV5277             NA         NA         NA       NA    
## ASV0281             NA         NA         NA       NA    
## ASV11181            NA         NA         NA       NA    
## ASV0254             NA         NA         NA       NA    
## ASV0201             NA         NA         NA       NA    
## ASV3656             NA         NA         NA       NA    
## ASV7994             NA         NA         NA       NA    
## ASV3584             NA         NA         NA       NA    
## ASV2157             NA         NA         NA       NA    
## ASV2935             NA         NA         NA       NA    
## ASV9024             NA         NA         NA       NA    
## ASV7711             NA         NA         NA       NA    
## ASV11330            NA         NA         NA       NA    
## ASV1875             NA         NA         NA       NA    
## ASV5861             NA         NA         NA       NA    
## ASV11562            NA         NA         NA       NA    
## ASV18559            NA         NA         NA       NA    
## ASV4384             NA         NA         NA       NA    
## ASV1302             NA         NA         NA       NA    
## ASV4673             NA         NA         NA       NA    
## ASV1956             NA         NA         NA       NA    
## ASV3286             NA         NA         NA       NA    
## ASV4866             NA         NA         NA       NA    
## ASV3129             NA         NA         NA       NA    
## ASV4104             NA         NA         NA       NA    
## ASV8983             NA         NA         NA       NA    
## ASV2201             NA         NA         NA       NA    
## ASV3055             NA         NA         NA       NA    
## ASV0534             NA         NA         NA       NA    
## ASV1019             NA         NA         NA       NA    
## ASV18482            NA         NA         NA       NA    
## ASV2694             NA         NA         NA       NA    
## ASV3412             NA         NA         NA       NA    
## ASV4174             NA         NA         NA       NA    
## ASV4281             NA         NA         NA       NA    
## ASV4949             NA         NA         NA       NA    
## ASV5881             NA         NA         NA       NA    
## ASV6299             NA         NA         NA       NA    
## ASV0676             NA         NA         NA       NA    
## ASV1066             NA         NA         NA       NA    
## ASV1300             NA         NA         NA       NA    
## ASV6455             NA         NA         NA       NA    
## ASV3455             NA         NA         NA       NA    
## ASV6531             NA         NA         NA       NA    
## ASV0490             NA         NA         NA       NA    
## ASV2588             NA         NA         NA       NA    
## ASV5364             NA         NA         NA       NA    
## ASV0981             NA         NA         NA       NA    
## ASV1563             NA         NA         NA       NA    
## ASV0376             NA         NA         NA       NA    
## ASV7308             NA         NA         NA       NA    
## ASV4817             NA         NA         NA       NA    
## ASV8716             NA         NA         NA       NA    
## ASV1849             NA         NA         NA       NA    
## ASV9423             NA         NA         NA       NA    
## ASV7690             NA         NA         NA       NA    
## ASV4901             NA         NA         NA       NA    
## ASV1830             NA         NA         NA       NA    
## ASV2316             NA         NA         NA       NA    
## ASV0693             NA         NA         NA       NA    
## ASV1243             NA         NA         NA       NA    
## ASV3867             NA         NA         NA       NA    
## ASV7932             NA         NA         NA       NA    
## ASV12608            NA         NA         NA       NA    
## ASV1661             NA         NA         NA       NA    
## ASV3957             NA         NA         NA       NA    
## ASV0830             NA         NA         NA       NA    
## ASV2078             NA         NA         NA       NA    
## ASV13932            NA         NA         NA       NA    
## ASV5300             NA         NA         NA       NA    
## ASV1014             NA         NA         NA       NA    
## ASV13059            NA         NA         NA       NA    
## ASV4340             NA         NA         NA       NA    
## ASV5591             NA         NA         NA       NA    
## ASV6040             NA         NA         NA       NA    
## ASV3904             NA         NA         NA       NA    
## ASV2267             NA         NA         NA       NA    
## ASV0573             NA         NA         NA       NA    
## ASV0851             NA         NA         NA       NA    
## ASV7805             NA         NA         NA       NA    
## ASV3379             NA         NA         NA       NA    
## ASV0825             NA         NA         NA       NA    
## ASV2461             NA         NA         NA       NA    
## ASV2783             NA         NA         NA       NA    
## ASV0925             NA         NA         NA       NA    
## ASV7023             NA         NA         NA       NA    
## ASV5319             NA         NA         NA       NA    
## ASV3213             NA         NA         NA       NA    
## ASV3748             NA         NA         NA       NA    
## ASV5491             NA         NA         NA       NA    
## ASV7931             NA         NA         NA       NA    
## ASV12767            NA         NA         NA       NA    
## ASV6389             NA         NA         NA       NA    
## ASV14867            NA         NA         NA       NA    
## ASV5105             NA         NA         NA       NA    
## ASV15927            NA         NA         NA       NA    
## ASV2004             NA         NA         NA       NA    
## ASV5554             NA         NA         NA       NA    
## ASV10929            NA         NA         NA       NA    
## ASV12778            NA         NA         NA       NA    
## ASV14006            NA         NA         NA       NA    
## ASV1603             NA         NA         NA       NA    
## ASV11948            NA         NA         NA       NA    
## ASV12912            NA         NA         NA       NA    
## ASV13147            NA         NA         NA       NA    
## ASV14761            NA         NA         NA       NA    
## ASV8521             NA         NA         NA       NA    
## ASV8581             NA         NA         NA       NA    
## ASV9875             NA         NA         NA       NA    
## ASV9986             NA         NA         NA       NA    
## ASV2376             NA         NA         NA       NA    
## ASV17535            NA         NA         NA       NA    
## ASV14330            NA         NA         NA       NA    
## ASV1333             NA         NA         NA       NA    
## ASV2498             NA         NA         NA       NA    
## ASV6352             NA         NA         NA       NA    
## ASV8601             NA         NA         NA       NA    
## ASV9776             NA         NA         NA       NA    
## ASV1916             NA         NA         NA       NA    
## ASV1555             NA         NA         NA       NA    
## ASV2499             NA         NA         NA       NA    
## ASV0703             NA         NA         NA       NA    
## ASV2047             NA         NA         NA       NA    
## ASV5492             NA         NA         NA       NA    
## ASV6549             NA         NA         NA       NA    
## ASV7757             NA         NA         NA       NA    
## ASV0173             NA         NA         NA       NA    
## ASV1248             NA         NA         NA       NA    
## ASV6502             NA         NA         NA       NA    
## ASV9844             NA         NA         NA       NA    
## ASV3903             NA         NA         NA       NA    
## ASV8199             NA         NA         NA       NA    
## ASV3309             NA         NA         NA       NA    
## ASV5826             NA         NA         NA       NA    
## ASV1480             NA         NA         NA       NA    
## ASV3090             NA         NA         NA       NA    
## ASV0758             NA         NA         NA       NA    
## ASV0811             NA         NA         NA       NA    
## ASV2653             NA         NA         NA       NA    
## ASV0978             NA         NA         NA       NA    
## ASV6640             NA         NA         NA       NA    
## ASV3423             NA         NA         NA       NA    
## ASV0617             NA         NA         NA       NA    
## ASV14947            NA         NA         NA       NA    
## ASV18367            NA         NA         NA       NA    
## ASV4574             NA         NA         NA       NA    
## ASV10514            NA         NA         NA       NA    
## ASV11779            NA         NA         NA       NA    
## ASV7528             NA         NA         NA       NA    
## ASV13153            NA         NA         NA       NA    
## ASV7858             NA         NA         NA       NA    
## ASV8722             NA         NA         NA       NA    
## ASV6585             NA         NA         NA       NA    
## ASV3311             NA         NA         NA       NA    
## ASV2469             NA         NA         NA       NA    
## ASV11340            NA         NA         NA       NA    
## ASV1718             NA         NA         NA       NA    
## ASV2117             NA         NA         NA       NA    
## ASV8252             NA         NA         NA       NA    
## ASV8533             NA         NA         NA       NA    
## ASV9507             NA         NA         NA       NA    
## ASV0706             NA         NA         NA       NA    
## ASV10312            NA         NA         NA       NA    
## ASV10696            NA         NA         NA       NA    
## ASV11203            NA         NA         NA       NA    
## ASV12147            NA         NA         NA       NA    
## ASV4602             NA         NA         NA       NA    
## ASV5568             NA         NA         NA       NA    
## ASV6777             NA         NA         NA       NA    
## ASV8749             NA         NA         NA       NA    
## ASV4780             NA         NA         NA       NA    
## ASV10116            NA         NA         NA       NA    
## ASV2907             NA         NA         NA       NA    
## ASV5165             NA         NA         NA       NA    
## ASV6061             NA         NA         NA       NA    
## ASV8082             NA         NA         NA       NA    
## ASV7696             NA         NA         NA       NA    
## ASV0550             NA         NA         NA       NA    
## ASV7745             NA         NA         NA       NA    
## ASV3607             NA         NA         NA       NA    
## ASV3877             NA         NA         NA       NA    
## ASV7667             NA         NA         NA       NA    
## ASV9293             NA         NA         NA       NA    
## ASV11653            NA         NA         NA       NA    
## ASV12850            NA         NA         NA       NA    
## ASV13104            NA         NA         NA       NA    
## ASV14208            NA         NA         NA       NA    
## ASV1552             NA         NA         NA       NA    
## ASV2501             NA         NA         NA       NA    
## ASV2893             NA         NA         NA       NA    
## ASV3084             NA         NA         NA       NA    
## ASV3599             NA         NA         NA       NA    
## ASV3868             NA         NA         NA       NA    
## ASV3917             NA         NA         NA       NA    
## ASV5695             NA         NA         NA       NA    
## ASV0131             NA         NA         NA       NA    
## ASV2847             NA         NA         NA       NA    
## ASV6875             NA         NA         NA       NA    
## ASV1547             NA         NA         NA       NA    
## ASV1501             NA         NA         NA       NA    
## ASV3876             NA         NA         NA       NA    
## ASV3456             NA         NA         NA       NA    
## ASV1194             NA         NA         NA       NA    
## ASV2135             NA         NA         NA       NA    
## ASV1352             NA         NA         NA       NA    
## ASV3208             NA         NA         NA       NA    
## ASV1164             NA         NA         NA       NA    
## ASV3492             NA         NA         NA       NA    
## ASV1601             NA         NA         NA       NA    
## ASV5347             NA         NA         NA       NA    
## ASV0293             NA         NA         NA       NA    
## ASV1509             NA         NA         NA       NA    
## ASV2801             NA         NA         NA       NA    
## ASV2873             NA         NA         NA       NA    
## ASV2162             NA         NA         NA       NA    
## ASV0462             NA         NA         NA       NA    
## ASV5367             NA         NA         NA       NA    
## ASV2715             NA         NA         NA       NA    
## ASV0371             NA         NA         NA       NA    
## ASV8090             NA         NA         NA       NA    
## ASV6320             NA         NA         NA       NA    
## ASV2562             NA         NA         NA       NA    
## ASV1505             NA         NA         NA       NA    
## ASV4924             NA         NA         NA       NA    
## ASV1437             NA         NA         NA       NA    
## ASV3816             NA         NA         NA       NA    
## ASV1969             NA         NA         NA       NA    
## ASV3146             NA         NA         NA       NA    
## ASV0321             NA         NA         NA       NA    
## ASV1020             NA         NA         NA       NA    
## ASV4138             NA         NA         NA       NA    
## ASV0329             NA         NA         NA       NA    
## ASV10647            NA         NA         NA       NA    
## ASV3389             NA         NA         NA       NA    
## ASV6880             NA         NA         NA       NA    
## ASV2624             NA         NA         NA       NA    
## ASV3686             NA         NA         NA       NA    
## ASV12302            NA         NA         NA       NA    
## ASV1184             NA         NA         NA       NA    
## ASV3533             NA         NA         NA       NA    
## ASV1735             NA         NA         NA       NA    
## ASV0483             NA         NA         NA       NA    
## ASV0928             NA         NA         NA       NA    
## ASV12254            NA         NA         NA       NA    
## ASV16025            NA         NA         NA       NA    
## ASV3070             NA         NA         NA       NA    
## ASV1850             NA         NA         NA       NA    
## ASV8946             NA         NA         NA       NA    
## ASV1536             NA         NA         NA       NA    
## ASV4151             NA         NA         NA       NA    
## ASV4585             NA         NA         NA       NA    
## ASV4921             NA         NA         NA       NA    
## ASV6172             NA         NA         NA       NA    
## ASV6375             NA         NA         NA       NA    
## ASV6501             NA         NA         NA       NA    
## ASV17095            NA         NA         NA       NA    
## ASV3679             NA         NA         NA       NA    
## ASV5750             NA         NA         NA       NA    
## ASV5922             NA         NA         NA       NA    
## ASV7323             NA         NA         NA       NA    
## ASV8515             NA         NA         NA       NA    
## ASV8753             NA         NA         NA       NA    
## ASV9197             NA         NA         NA       NA    
## ASV1778             NA         NA         NA       NA    
## ASV1241             NA         NA         NA       NA    
## ASV1717             NA         NA         NA       NA    
## ASV1112             NA         NA         NA       NA    
## ASV3994             NA         NA         NA       NA    
## ASV5511             NA         NA         NA       NA    
## ASV8706             NA         NA         NA       NA    
## ASV3049             NA         NA         NA       NA    
## ASV4332             NA         NA         NA       NA    
## ASV7411             NA         NA         NA       NA    
## ASV7475             NA         NA         NA       NA    
## ASV8988             NA         NA         NA       NA    
## ASV0688             NA         NA         NA       NA    
## ASV1946             NA         NA         NA       NA    
## ASV3150             NA         NA         NA       NA    
## ASV3508             NA         NA         NA       NA    
## ASV3863             NA         NA         NA       NA    
## ASV4544             NA         NA         NA       NA    
## ASV4567             NA         NA         NA       NA    
## ASV4855             NA         NA         NA       NA    
## ASV4872             NA         NA         NA       NA    
## ASV4881             NA         NA         NA       NA    
## ASV5283             NA         NA         NA       NA    
## ASV5302             NA         NA         NA       NA    
## ASV5909             NA         NA         NA       NA    
## ASV5933             NA         NA         NA       NA    
## ASV6019             NA         NA         NA       NA    
## ASV6043             NA         NA         NA       NA    
## ASV6908             NA         NA         NA       NA    
## ASV7245             NA         NA         NA       NA    
## ASV7249             NA         NA         NA       NA    
## ASV8349             NA         NA         NA       NA    
## ASV7310             NA         NA         NA       NA    
## ASV1893             NA         NA         NA       NA    
## ASV2354             NA         NA         NA       NA    
## ASV3435             NA         NA         NA       NA    
## ASV0480             NA         NA         NA       NA    
## ASV0955             NA         NA         NA       NA    
## ASV10000            NA         NA         NA       NA    
## ASV7215             NA         NA         NA       NA    
## ASV10423            NA         NA         NA       NA    
## ASV6008             NA         NA         NA       NA    
## ASV9330             NA         NA         NA       NA    
## ASV6051             NA         NA         NA       NA    
## ASV1675             NA         NA         NA       NA    
## ASV2043             NA         NA         NA       NA    
## ASV3634             NA         NA         NA       NA    
## ASV4077             NA         NA         NA       NA    
## ASV4754             NA         NA         NA       NA    
## ASV6095             NA         NA         NA       NA    
## ASV6288             NA         NA         NA       NA    
## ASV6507             NA         NA         NA       NA    
## ASV8905             NA         NA         NA       NA    
## ASV9728             NA         NA         NA       NA    
## ASV11144            NA         NA         NA       NA    
## ASV1615             NA         NA         NA       NA    
## ASV2709             NA         NA         NA       NA    
## ASV3003             NA         NA         NA       NA    
## ASV5163             NA         NA         NA       NA    
## ASV6622             NA         NA         NA       NA    
## ASV1076             NA         NA         NA       NA    
## ASV7895             NA         NA         NA       NA    
## ASV10577            NA         NA         NA       NA    
## ASV1272             NA         NA         NA       NA    
## ASV2492             NA         NA         NA       NA    
## ASV5195             NA         NA         NA       NA    
## ASV5267             NA         NA         NA       NA    
## ASV6317             NA         NA         NA       NA    
## ASV2296             NA         NA         NA       NA    
## ASV2290             NA         NA         NA       NA    
## ASV3726             NA         NA         NA       NA    
## ASV1169             NA         NA         NA       NA    
## ASV0189             NA         NA         NA       NA    
## ASV2729             NA         NA         NA       NA    
## ASV3469             NA         NA         NA       NA    
## ASV0762             NA         NA         NA       NA    
## ASV9001             NA         NA         NA       NA    
## ASV14604            NA         NA         NA       NA    
## ASV7439             NA         NA         NA       NA    
## ASV8625             NA         NA         NA       NA    
## ASV11553            NA         NA         NA       NA    
## ASV14440            NA         NA         NA       NA    
## ASV16106            NA         NA         NA       NA    
## ASV16110            NA         NA         NA       NA    
## ASV2229             NA         NA         NA       NA    
## ASV3854             NA         NA         NA       NA    
## ASV5512             NA         NA         NA       NA    
## ASV5939             NA         NA         NA       NA    
## ASV6676             NA         NA         NA       NA    
## ASV8381             NA         NA         NA       NA    
## ASV2735             NA         NA         NA       NA    
## ASV9816             NA         NA         NA       NA    
## ASV1382             NA         NA         NA       NA    
## ASV1408             NA         NA         NA       NA    
## ASV4902             NA         NA         NA       NA    
## ASV5600             NA         NA         NA       NA    
## ASV0815             NA         NA         NA       NA    
## ASV11867            NA         NA         NA       NA    
## ASV16064            NA         NA         NA       NA    
## ASV2250             NA         NA         NA       NA    
## ASV2417             NA         NA         NA       NA    
## ASV2807             NA         NA         NA       NA    
## ASV3224             NA         NA         NA       NA    
## ASV4115             NA         NA         NA       NA    
## ASV4876             NA         NA         NA       NA    
## ASV5291             NA         NA         NA       NA    
## ASV5834             NA         NA         NA       NA    
## ASV6896             NA         NA         NA       NA    
## ASV7292             NA         NA         NA       NA    
## ASV7924             NA         NA         NA       NA    
## ASV0710             NA         NA         NA       NA    
## ASV1925             NA         NA         NA       NA    
## ASV4247             NA         NA         NA       NA    
## ASV4549             NA         NA         NA       NA    
## ASV4076             NA         NA         NA       NA    
## ASV7063             NA         NA         NA       NA    
## ASV1487             NA         NA         NA       NA    
## ASV1405             NA         NA         NA       NA    
## ASV3851             NA         NA         NA       NA    
## ASV0896             NA         NA         NA       NA    
## ASV5581             NA         NA         NA       NA    
## ASV7053             NA         NA         NA       NA    
## ASV7171             NA         NA         NA       NA    
## ASV4017             NA         NA         NA       NA    
## ASV5846             NA         NA         NA       NA    
## ASV0203             NA         NA         NA       NA    
## ASV13271            NA         NA         NA       NA    
## ASV9487             NA         NA         NA       NA    
## ASV2056             NA         NA         NA       NA    
## ASV16933            NA         NA         NA       NA    
## ASV0360             NA         NA         NA       NA    
## ASV1798             NA         NA         NA       NA    
## ASV17286            NA         NA         NA       NA    
## ASV8175             NA         NA         NA       NA    
## ASV6679             NA         NA         NA       NA    
## ASV6776             NA         NA         NA       NA    
## ASV9062             NA         NA         NA       NA    
## ASV9564             NA         NA         NA       NA    
## ASV6431             NA         NA         NA       NA    
## ASV9940             NA         NA         NA       NA    
## ASV7001             NA         NA         NA       NA    
## ASV3044             NA         NA         NA       NA    
## ASV6684             NA         NA         NA       NA    
## ASV12278            NA         NA         NA       NA    
## ASV3543             NA         NA         NA       NA    
## ASV6397             NA         NA         NA       NA    
## ASV9939             NA         NA         NA       NA    
## ASV9432             NA         NA         NA       NA    
## ASV2630             NA         NA         NA       NA    
## ASV2175             NA         NA         NA       NA    
## ASV4107             NA         NA         NA       NA    
## ASV9172             NA         NA         NA       NA    
## ASV3141             NA         NA         NA       NA    
## ASV9010             NA         NA         NA       NA    
## ASV2550             NA         NA         NA       NA    
## ASV5845             NA         NA         NA       NA    
## ASV3998             NA         NA         NA       NA    
## ASV1389             NA         NA         NA       NA    
## ASV0615             NA         NA         NA       NA    
## ASV9127             NA         NA         NA       NA    
## ASV1190             NA         NA         NA       NA    
## ASV1211             NA         NA         NA       NA    
## ASV1766             NA         NA         NA       NA    
## ASV2337             NA         NA         NA       NA    
## ASV2463             NA         NA         NA       NA    
## ASV2806             NA         NA         NA       NA    
## ASV0439             NA         NA         NA       NA    
## ASV0839             NA         NA         NA       NA    
## ASV14975            NA         NA         NA       NA    
## ASV17712            NA         NA         NA       NA    
## ASV2010             NA         NA         NA       NA    
## ASV2041             NA         NA         NA       NA    
## ASV2124             NA         NA         NA       NA    
## ASV2585             NA         NA         NA       NA    
## ASV3314             NA         NA         NA       NA    
## ASV5051             NA         NA         NA       NA    
## ASV10784            NA         NA         NA       NA    
## ASV3279             NA         NA         NA       NA    
## ASV9498             NA         NA         NA       NA    
## ASV1059             NA         NA         NA       NA    
## ASV13008            NA         NA         NA       NA    
## ASV15803            NA         NA         NA       NA    
## ASV2559             NA         NA         NA       NA    
## ASV2623             NA         NA         NA       NA    
## ASV2802             NA         NA         NA       NA    
## ASV3799             NA         NA         NA       NA    
## ASV5274             NA         NA         NA       NA    
## ASV5835             NA         NA         NA       NA    
## ASV7251             NA         NA         NA       NA    
## ASV7616             NA         NA         NA       NA    
## ASV9576             NA         NA         NA       NA    
## ASV2870             NA         NA         NA       NA    
## ASV3668             NA         NA         NA       NA    
## ASV1633             NA         NA         NA       NA    
## ASV6060             NA         NA         NA       NA    
## ASV6305             NA         NA         NA       NA    
## ASV5164             NA         NA         NA       NA    
## ASV7252             NA         NA         NA       NA    
## ASV9343             NA         NA         NA       NA    
## ASV6835             NA         NA         NA       NA    
## ASV1264             NA         NA         NA       NA    
## ASV0591             NA         NA         NA       NA    
## ASV1351             NA         NA         NA       NA    
## ASV14224            NA         NA         NA       NA    
## ASV1432             NA         NA         NA       NA    
## ASV1559             NA         NA         NA       NA    
## ASV2182             NA         NA         NA       NA    
## ASV2304             NA         NA         NA       NA    
## ASV6838             NA         NA         NA       NA    
## ASV1125             NA         NA         NA       NA    
## ASV17948            NA         NA         NA       NA    
## ASV2609             NA         NA         NA       NA    
## ASV6128             NA         NA         NA       NA    
## ASV1338             NA         NA         NA       NA    
## ASV2136             NA         NA         NA       NA    
## ASV0929             NA         NA         NA       NA    
## ASV3479             NA         NA         NA       NA    
## ASV0886             NA         NA         NA       NA    
## ASV1652             NA         NA         NA       NA    
## ASV1160             NA         NA         NA       NA    
## ASV5260             NA         NA         NA       NA    
## ASV2352             NA         NA         NA       NA    
## ASV0986             NA         NA         NA       NA    
## ASV2021             NA         NA         NA       NA    
## ASV16599            NA         NA         NA       NA    
## ASV3497             NA         NA         NA       NA    
## ASV1305             NA         NA         NA       NA    
## ASV0927             NA         NA         NA       NA    
## ASV0647             NA         NA         NA       NA    
## ASV1832             NA         NA         NA       NA    
## ASV1277             NA         NA         NA       NA    
## ASV22332            NA         NA         NA       NA    
## ASV10080            NA         NA         NA       NA    
## ASV14157            NA         NA         NA       NA    
## ASV15829            NA         NA         NA       NA    
## ASV3609             NA         NA         NA       NA    
## ASV5737             NA         NA         NA       NA    
## ASV1474             NA         NA         NA       NA    
## ASV2028             NA         NA         NA       NA    
## ASV0818             NA         NA         NA       NA    
## ASV0505             NA         NA         NA       NA    
## ASV1813             NA         NA         NA       NA    
## ASV0512             NA         NA         NA       NA    
## ASV5374             NA         NA         NA       NA    
## ASV2927             NA         NA         NA       NA    
## ASV3596             NA         NA         NA       NA    
## ASV1137             NA         NA         NA       NA    
## ASV4541             NA         NA         NA       NA    
## ASV9872             NA         NA         NA       NA    
## ASV0359             NA         NA         NA       NA    
## ASV0720             NA         NA         NA       NA    
## ASV10545            NA         NA         NA       NA    
## ASV13384            NA         NA         NA       NA    
## ASV1456             NA         NA         NA       NA    
## ASV1751             NA         NA         NA       NA    
## ASV18419            NA         NA         NA       NA    
## ASV2970             NA         NA         NA       NA    
## ASV4215             NA         NA         NA       NA    
## ASV4742             NA         NA         NA       NA    
## ASV5017             NA         NA         NA       NA    
## ASV5139             NA         NA         NA       NA    
## ASV9133             NA         NA         NA       NA    
## ASV9447             NA         NA         NA       NA    
## ASV0842             NA         NA         NA       NA    
## ASV12293            NA         NA         NA       NA    
## ASV1965             NA         NA         NA       NA    
## ASV2005             NA         NA         NA       NA    
## ASV5335             NA         NA         NA       NA    
## ASV6438             NA         NA         NA       NA    
## ASV7798             NA         NA         NA       NA    
## ASV2691             NA         NA         NA       NA    
## ASV9958             NA         NA         NA       NA    
## ASV1512             NA         NA         NA       NA    
## ASV1226             NA         NA         NA       NA    
## ASV2130             NA         NA         NA       NA    
## ASV0874             NA         NA         NA       NA    
## ASV5436             NA         NA         NA       NA    
## ASV0383             NA         NA         NA       NA    
## ASV1882             NA         NA         NA       NA    
## ASV2471             NA         NA         NA       NA    
## ASV4049             NA         NA         NA       NA    
## ASV3014             NA         NA         NA       NA    
## ASV0316             NA         NA         NA       NA    
## ASV1621             NA         NA         NA       NA    
## ASV13266            NA         NA         NA       NA    
## ASV1635             NA         NA         NA       NA    
## ASV2042             NA         NA         NA       NA    
## ASV2317             NA         NA         NA       NA    
## ASV3697             NA         NA         NA       NA    
## ASV6404             NA         NA         NA       NA    
## ASV15616            NA         NA         NA       NA    
## ASV10783            NA         NA         NA       NA    
## ASV6912             NA         NA         NA       NA    
## ASV1561             NA         NA         NA       NA    
## ASV4404             NA         NA         NA       NA    
## ASV1110             NA         NA         NA       NA    
## ASV2844             NA         NA         NA       NA    
## ASV5224             NA         NA         NA       NA    
## ASV6300             NA         NA         NA       NA    
## ASV8078             NA         NA         NA       NA    
## ASV9722             NA         NA         NA       NA    
## ASV6911             NA         NA         NA       NA    
## ASV5474             NA         NA         NA       NA    
## ASV2761             NA         NA         NA       NA    
## ASV5943             NA         NA         NA       NA    
## ASV0600             NA         NA         NA       NA    
## ASV0608             NA         NA         NA       NA    
## ASV1586             NA         NA         NA       NA    
## ASV0206             NA         NA         NA       NA    
## ASV4042             NA         NA         NA       NA    
## ASV5304             NA         NA         NA       NA    
## ASV0949             NA         NA         NA       NA    
## ASV1856             NA         NA         NA       NA    
## ASV2584             NA         NA         NA       NA    
## ASV2287             NA         NA         NA       NA    
## ASV2364             NA         NA         NA       NA    
## ASV11481            NA         NA         NA       NA    
## ASV2906             NA         NA         NA       NA    
## ASV0161             NA         NA         NA       NA    
## ASV0062             NA         NA         NA       NA    
## ASV3811             NA         NA         NA       NA    
## ASV0225             NA         NA         NA       NA    
## ASV4672             NA         NA         NA       NA    
## ASV1607             NA         NA         NA       NA    
## ASV3060             NA         NA         NA       NA    
## ASV2275             NA         NA         NA       NA    
## ASV5375             NA         NA         NA       NA    
## ASV0352             NA         NA         NA       NA    
## ASV1107             NA         NA         NA       NA    
## ASV4887             NA         NA         NA       NA    
## ASV2397             NA         NA         NA       NA    
## ASV7541             NA         NA         NA       NA    
## ASV7387             NA         NA         NA       NA    
## ASV1355             NA         NA         NA       NA    
## ASV1764             NA         NA         NA       NA    
## ASV1960             NA         NA         NA       NA    
## ASV0484             NA         NA         NA       NA    
## ASV2487             NA         NA         NA       NA    
## ASV0422             NA         NA         NA       NA    
## ASV0081             NA         NA         NA       NA    
## ASV1341             NA         NA         NA       NA    
## ASV1001             NA         NA         NA       NA    
## ASV0317             NA         NA         NA       NA    
## ASV2728             NA         NA         NA       NA    
## ASV0884             NA         NA         NA       NA    
## ASV0464             NA         NA         NA       NA    
## ASV2963             NA         NA         NA       NA    
## ASV4608             NA         NA         NA       NA    
## ASV3534             NA         NA         NA       NA    
## ASV0291             NA         NA         NA       NA    
## ASV0635             NA         NA         NA       NA    
## ASV0867             NA         NA         NA       NA    
## ASV1206             NA         NA         NA       NA    
## ASV1230             NA         NA         NA       NA    
## ASV1265             NA         NA         NA       NA    
## ASV1291             NA         NA         NA       NA    
## ASV1524             NA         NA         NA       NA    
## ASV2153             NA         NA         NA       NA    
## ASV2714             NA         NA         NA       NA    
## ASV4246             NA         NA         NA       NA    
## ASV0945             NA         NA         NA       NA    
## ASV2380             NA         NA         NA       NA    
## ASV0214             NA         NA         NA       NA    
## ASV10461            NA         NA         NA       NA    
## ASV4177             NA         NA         NA       NA    
## ASV0237             NA         NA         NA       NA    
## ASV11323            NA         NA         NA       NA    
## ASV2232             NA         NA         NA       NA    
## ASV0115             NA         NA         NA       NA    
## ASV1171             NA         NA         NA       NA    
## ASV1942             NA         NA         NA       NA    
## ASV1889             NA         NA         NA       NA    
## ASV0920             NA         NA         NA       NA    
## ASV1805             NA         NA         NA       NA    
## ASV1712             NA         NA         NA       NA    
## ASV1458             NA         NA         NA       NA    
## ASV1985             NA         NA         NA       NA    
## ASV2960             NA         NA         NA       NA    
## ASV5207             NA         NA         NA       NA    
## ASV8548             NA         NA         NA       NA    
## ASV0449             NA         NA         NA       NA    
## ASV0609             NA         NA         NA       NA    
## ASV1038             NA         NA         NA       NA    
## ASV1145             NA         NA         NA       NA    
## ASV15767            NA         NA         NA       NA    
## ASV1630             NA         NA         NA       NA    
## ASV1911             NA         NA         NA       NA    
## ASV1950             NA         NA         NA       NA    
## ASV2583             NA         NA         NA       NA    
## ASV2853             NA         NA         NA       NA    
## ASV2948             NA         NA         NA       NA    
## ASV3116             NA         NA         NA       NA    
## ASV3160             NA         NA         NA       NA    
## ASV3354             NA         NA         NA       NA    
## ASV3368             NA         NA         NA       NA    
## ASV3464             NA         NA         NA       NA    
## ASV3577             NA         NA         NA       NA    
## ASV3746             NA         NA         NA       NA    
## ASV3942             NA         NA         NA       NA    
## ASV4000             NA         NA         NA       NA    
## ASV4207             NA         NA         NA       NA    
## ASV4261             NA         NA         NA       NA    
## ASV4466             NA         NA         NA       NA    
## ASV4487             NA         NA         NA       NA    
## ASV4572             NA         NA         NA       NA    
## ASV4718             NA         NA         NA       NA    
## ASV4757             NA         NA         NA       NA    
## ASV4929             NA         NA         NA       NA    
## ASV5611             NA         NA         NA       NA    
## ASV5614             NA         NA         NA       NA    
## ASV5898             NA         NA         NA       NA    
## ASV7627             NA         NA         NA       NA    
## ASV3105             NA         NA         NA       NA    
## ASV4762             NA         NA         NA       NA    
## ASV5622             NA         NA         NA       NA    
## ASV7129             NA         NA         NA       NA    
## ASV12138            NA         NA         NA       NA    
## ASV1687             NA         NA         NA       NA    
## ASV2187             NA         NA         NA       NA    
## ASV2204             NA         NA         NA       NA    
## ASV2914             NA         NA         NA       NA    
## ASV3297             NA         NA         NA       NA    
## ASV3310             NA         NA         NA       NA    
## ASV3677             NA         NA         NA       NA    
## ASV4508             NA         NA         NA       NA    
## ASV6236             NA         NA         NA       NA    
## ASV6285             NA         NA         NA       NA    
## ASV7576             NA         NA         NA       NA    
## ASV7917             NA         NA         NA       NA    
## ASV9353             NA         NA         NA       NA    
## ASV1656             NA         NA         NA       NA    
## ASV0280             NA         NA         NA       NA    
## ASV4747             NA         NA         NA       NA    
## ASV2108             NA         NA         NA       NA    
## ASV0885             NA         NA         NA       NA    
## ASV2538             NA         NA         NA       NA    
## ASV0968             NA         NA         NA       NA    
## ASV1229             NA         NA         NA       NA    
## ASV13306            NA         NA         NA       NA    
## ASV13952            NA         NA         NA       NA    
## ASV14631            NA         NA         NA       NA    
## ASV2119             NA         NA         NA       NA    
## ASV2450             NA         NA         NA       NA    
## ASV2656             NA         NA         NA       NA    
## ASV2942             NA         NA         NA       NA    
## ASV3302             NA         NA         NA       NA    
## ASV6515             NA         NA         NA       NA    
## ASV6674             NA         NA         NA       NA    
## ASV7296             NA         NA         NA       NA    
## ASV7903             NA         NA         NA       NA    
## ASV7943             NA         NA         NA       NA    
## ASV8864             NA         NA         NA       NA    
## ASV9389             NA         NA         NA       NA    
## ASV9869             NA         NA         NA       NA    
## ASV1051             NA         NA         NA       NA    
## ASV13035            NA         NA         NA       NA    
## ASV15744            NA         NA         NA       NA    
## ASV2526             NA         NA         NA       NA    
## ASV1156             NA         NA         NA       NA    
## ASV13562            NA         NA         NA       NA    
## ASV1438             NA         NA         NA       NA    
## ASV2268             NA         NA         NA       NA    
## ASV2797             NA         NA         NA       NA    
## ASV3744             NA         NA         NA       NA    
## ASV8076             NA         NA         NA       NA    
## ASV7055             NA         NA         NA       NA    
## ASV7493             NA         NA         NA       NA    
## ASV1201             NA         NA         NA       NA    
## ASV5736             NA         NA         NA       NA    
## ASV0558             NA         NA         NA       NA    
## ASV14399            NA         NA         NA       NA    
## ASV2992             NA         NA         NA       NA    
## ASV4303             NA         NA         NA       NA    
## ASV0565             NA         NA         NA       NA    
## ASV0977             NA         NA         NA       NA    
## ASV0140             NA         NA         NA       NA    
## ASV14421            NA         NA         NA       NA    
## ASV16909            NA         NA         NA       NA    
## ASV3762             NA         NA         NA       NA    
## ASV7141             NA         NA         NA       NA    
## ASV3291             NA         NA         NA       NA    
## ASV10440            NA         NA         NA       NA    
## ASV10802            NA         NA         NA       NA    
## ASV1698             NA         NA         NA       NA    
## ASV2121             NA         NA         NA       NA    
## ASV3549             NA         NA         NA       NA    
## ASV6379             NA         NA         NA       NA    
## ASV6824             NA         NA         NA       NA    
## ASV8254             NA         NA         NA       NA    
## ASV9951             NA         NA         NA       NA    
## ASV1515             NA         NA         NA       NA    
## ASV4327             NA         NA         NA       NA    
## ASV0341             NA         NA         NA       NA    
## ASV5562             NA         NA         NA       NA    
## ASV1412             NA         NA         NA       NA    
## ASV0154             NA         NA         NA       NA    
## ASV3163             NA         NA         NA       NA    
## ASV1782             NA         NA         NA       NA    
## ASV3993             NA         NA         NA       NA    
## ASV3164             NA         NA         NA       NA    
## ASV1024             NA         NA         NA       NA    
## ASV0771             NA         NA         NA       NA    
## ASV2223             NA         NA         NA       NA    
## ASV1638             NA         NA         NA       NA    
## ASV0232             NA         NA         NA       NA    
## ASV6771             NA         NA         NA       NA    
## ASV4243             NA         NA         NA       NA    
## ASV0162             NA         NA         NA       NA    
## ASV0049             NA         NA         NA       NA    
## ASV4697             NA         NA         NA       NA    
## ASV12326            NA         NA         NA       NA    
## ASV12586            NA         NA         NA       NA    
## ASV1879             NA         NA         NA       NA    
## ASV2864             NA         NA         NA       NA    
## ASV3111             NA         NA         NA       NA    
## ASV5633             NA         NA         NA       NA    
## ASV5864             NA         NA         NA       NA    
## ASV6364             NA         NA         NA       NA    
## ASV1598             NA         NA         NA       NA    
## ASV2649             NA         NA         NA       NA    
## ASV4664             NA         NA         NA       NA    
## ASV2654             NA         NA         NA       NA    
## ASV6636             NA         NA         NA       NA    
## ASV3334             NA         NA         NA       NA    
## ASV0046             NA         NA         NA       NA    
## ASV0661             NA         NA         NA       NA    
## ASV0774             NA         NA         NA       NA    
## ASV3815             NA         NA         NA       NA    
## ASV0575             NA         NA         NA       NA    
## ASV1953             NA         NA         NA       NA    
## ASV0610             NA         NA         NA       NA    
## ASV0245             NA         NA         NA       NA    
## ASV3805             NA         NA         NA       NA    
## ASV1182             NA         NA         NA       NA    
## ASV1941             NA         NA         NA       NA    
## ASV0080             NA         NA         NA       NA    
## ASV1033             NA         NA         NA       NA    
## ASV5330             NA         NA         NA       NA    
## ASV9702             NA         NA         NA       NA    
## ASV0358             NA         NA         NA       NA    
## ASV2225             NA         NA         NA       NA    
## ASV2606             NA         NA         NA       NA    
## ASV3510             NA         NA         NA       NA    
## ASV3069             NA         NA         NA       NA    
## ASV3849             NA         NA         NA       NA    
## ASV1810             NA         NA         NA       NA    
## ASV2046             NA         NA         NA       NA    
## ASV2451             NA         NA         NA       NA    
## ASV4047             NA         NA         NA       NA    
## ASV7402             NA         NA         NA       NA    
## ASV8250             NA         NA         NA       NA    
## ASV3468             NA         NA         NA       NA    
## ASV3521             NA         NA         NA       NA    
## ASV6363             NA         NA         NA       NA    
## ASV6444             NA         NA         NA       NA    
## ASV8231             NA         NA         NA       NA    
## ASV0196             NA         NA         NA       NA    
## ASV12801            NA         NA         NA       NA    
## ASV12906            NA         NA         NA       NA    
## ASV13040            NA         NA         NA       NA    
## ASV1313             NA         NA         NA       NA    
## ASV14008            NA         NA         NA       NA    
## ASV1546             NA         NA         NA       NA    
## ASV1637             NA         NA         NA       NA    
## ASV17076            NA         NA         NA       NA    
## ASV2061             NA         NA         NA       NA    
## ASV2177             NA         NA         NA       NA    
## ASV2943             NA         NA         NA       NA    
## ASV3020             NA         NA         NA       NA    
## ASV30254            NA         NA         NA       NA    
## ASV3219             NA         NA         NA       NA    
## ASV3352             NA         NA         NA       NA    
## ASV3355             NA         NA         NA       NA    
## ASV3377             NA         NA         NA       NA    
## ASV3449             NA         NA         NA       NA    
## ASV3893             NA         NA         NA       NA    
## ASV4326             NA         NA         NA       NA    
## ASV5016             NA         NA         NA       NA    
## ASV5152             NA         NA         NA       NA    
## ASV5666             NA         NA         NA       NA    
## ASV5802             NA         NA         NA       NA    
## ASV6070             NA         NA         NA       NA    
## ASV6488             NA         NA         NA       NA    
## ASV6562             NA         NA         NA       NA    
## ASV6930             NA         NA         NA       NA    
## ASV7243             NA         NA         NA       NA    
## ASV7506             NA         NA         NA       NA    
## ASV7553             NA         NA         NA       NA    
## ASV8064             NA         NA         NA       NA    
## ASV8434             NA         NA         NA       NA    
## ASV8858             NA         NA         NA       NA    
## ASV2600             NA         NA         NA       NA    
## ASV3398             NA         NA         NA       NA    
## ASV4584             NA         NA         NA       NA    
## ASV4864             NA         NA         NA       NA    
## ASV0082             NA         NA         NA       NA    
## ASV9626             NA         NA         NA       NA    
## ASV1617             NA         NA         NA       NA    
## ASV2765             NA         NA         NA       NA    
## ASV2167             NA         NA         NA       NA    
## ASV1628             NA         NA         NA       NA    
## ASV3260             NA         NA         NA       NA    
## ASV3645             NA         NA         NA       NA    
## ASV6057             NA         NA         NA       NA    
## ASV0662             NA         NA         NA       NA    
## ASV4267             NA         NA         NA       NA    
## ASV1070             NA         NA         NA       NA    
## ASV0633             NA         NA         NA       NA    
## ASV0333             NA         NA         NA       NA    
## ASV0966             NA         NA         NA       NA    
## ASV1848             NA         NA         NA       NA    
## ASV13390            NA         NA         NA       NA    
## ASV14901            NA         NA         NA       NA    
## ASV1676             NA         NA         NA       NA    
## ASV1756             NA         NA         NA       NA    
## ASV22537            NA         NA         NA       NA    
## ASV3303             NA         NA         NA       NA    
## ASV4030             NA         NA         NA       NA    
## ASV4871             NA         NA         NA       NA    
## ASV5536             NA         NA         NA       NA    
## ASV5700             NA         NA         NA       NA    
## ASV8957             NA         NA         NA       NA    
## ASV11210            NA         NA         NA       NA    
## ASV7585             NA         NA         NA       NA    
## ASV8596             NA         NA         NA       NA    
## ASV9532             NA         NA         NA       NA    
## ASV4254             NA         NA         NA       NA    
## ASV13299            NA         NA         NA       NA    
## ASV15627            NA         NA         NA       NA    
## ASV6302             NA         NA         NA       NA    
## ASV3040             NA         NA         NA       NA    
## ASV0632             NA         NA         NA       NA    
## ASV3694             NA         NA         NA       NA    
## ASV1592             NA         NA         NA       NA    
## ASV0538             NA         NA         NA       NA    
## ASV0832             NA         NA         NA       NA    
## ASV0727             NA         NA         NA       NA    
## ASV1165             NA         NA         NA       NA    
## ASV1325             NA         NA         NA       NA    
## ASV0819             NA         NA         NA       NA    
## ASV2251             NA         NA         NA       NA    
## ASV0100             NA         NA         NA       NA    
## ASV0444             NA         NA         NA       NA    
## ASV0800             NA         NA         NA       NA    
## ASV2432             NA         NA         NA       NA    
## ASV2883             NA         NA         NA       NA    
## ASV3894             NA         NA         NA       NA    
## ASV2367             NA         NA         NA       NA    
## ASV3724             NA         NA         NA       NA    
## ASV2112             NA         NA         NA       NA    
## ASV3661             NA         NA         NA       NA    
## ASV2096             NA         NA         NA       NA    
## ASV3551             NA         NA         NA       NA    
## ASV11343            NA         NA         NA       NA    
## ASV2051             NA         NA         NA       NA    
## ASV2617             NA         NA         NA       NA    
## ASV0125             NA         NA         NA       NA    
## ASV0372             NA         NA         NA       NA    
## ASV6751             NA         NA         NA       NA    
## ASV10810            NA         NA         NA       NA    
## ASV0461             NA         NA         NA       NA    
## ASV1945             NA         NA         NA       NA    
## ASV0882             NA         NA         NA       NA    
## ASV4040             NA         NA         NA       NA    
## ASV0109             NA         NA         NA       NA    
## ASV0174             NA         NA         NA       NA    
## ASV2851             NA         NA         NA       NA    
## ASV5312             NA         NA         NA       NA    
## ASV9402             NA         NA         NA       NA    
## ASV4870             NA         NA         NA       NA    
## ASV0589             NA         NA         NA       NA    
## ASV1221             NA         NA         NA       NA    
## ASV6028             NA         NA         NA       NA    
## ASV5106             NA         NA         NA       NA    
## ASV4977             NA         NA         NA       NA    
## ASV5715             NA         NA         NA       NA    
## ASV4182             NA         NA         NA       NA    
## ASV2383             NA         NA         NA       NA    
## ASV3985             NA         NA         NA       NA    
## ASV2787             NA         NA         NA       NA    
## ASV6756             NA         NA         NA       NA    
## ASV1634             NA         NA         NA       NA    
## ASV0649             NA         NA         NA       NA    
## ASV1591             NA         NA         NA       NA    
## ASV1854             NA         NA         NA       NA    
## ASV4205             NA         NA         NA       NA    
## ASV3293             NA         NA         NA       NA    
## ASV1631             NA         NA         NA       NA    
## ASV1747             NA         NA         NA       NA    
## ASV5634             NA         NA         NA       NA    
## ASV0965             NA         NA         NA       NA    
## ASV1094             NA         NA         NA       NA    
## ASV2744             NA         NA         NA       NA    
## ASV7212             NA         NA         NA       NA    
## ASV0344             NA         NA         NA       NA    
## ASV11812            NA         NA         NA       NA    
## ASV7867             NA         NA         NA       NA    
## ASV6670             NA         NA         NA       NA    
## ASV10991            NA         NA         NA       NA    
## ASV1281             NA         NA         NA       NA    
## ASV12845            NA         NA         NA       NA    
## ASV1833             NA         NA         NA       NA    
## ASV2211             NA         NA         NA       NA    
## ASV3920             NA         NA         NA       NA    
## ASV4545             NA         NA         NA       NA    
## ASV4710             NA         NA         NA       NA    
## ASV4978             NA         NA         NA       NA    
## ASV9630             NA         NA         NA       NA    
## ASV9797             NA         NA         NA       NA    
## ASV13469            NA         NA         NA       NA    
## ASV14961            NA         NA         NA       NA    
## ASV6259             NA         NA         NA       NA    
## ASV6294             NA         NA         NA       NA    
## ASV6883             NA         NA         NA       NA    
## ASV7041             NA         NA         NA       NA    
## ASV4363             NA         NA         NA       NA    
## ASV1784             NA         NA         NA       NA    
## ASV2140             NA         NA         NA       NA    
## ASV3202             NA         NA         NA       NA    
## ASV6017             NA         NA         NA       NA    
## ASV9129             NA         NA         NA       NA    
## ASV0917             NA         NA         NA       NA    
## ASV10584            NA         NA         NA       NA    
## ASV11218            NA         NA         NA       NA    
## ASV11229            NA         NA         NA       NA    
## ASV11604            NA         NA         NA       NA    
## ASV2103             NA         NA         NA       NA    
## ASV2165             NA         NA         NA       NA    
## ASV2340             NA         NA         NA       NA    
## ASV3738             NA         NA         NA       NA    
## ASV4012             NA         NA         NA       NA    
## ASV4094             NA         NA         NA       NA    
## ASV4454             NA         NA         NA       NA    
## ASV7031             NA         NA         NA       NA    
## ASV7087             NA         NA         NA       NA    
## ASV4159             NA         NA         NA       NA    
## ASV5084             NA         NA         NA       NA    
## ASV6584             NA         NA         NA       NA    
## ASV9614             NA         NA         NA       NA    
## ASV16068            NA         NA         NA       NA    
## ASV2141             NA         NA         NA       NA    
## ASV0395             NA         NA         NA       NA    
## ASV5640             NA         NA         NA       NA    
## ASV2854             NA         NA         NA       NA    
## ASV3825             NA         NA         NA       NA    
## ASV0481             NA         NA         NA       NA    
## ASV3304             NA         NA         NA       NA    
## ASV0445             NA         NA         NA       NA    
## ASV1845             NA         NA         NA       NA    
## ASV3110             NA         NA         NA       NA    
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
## (Dispersion parameter for binomial family taken to be 1)
## 
##     Null deviance:   385.39  on 277  degrees of freedom
## Residual deviance: 11750.23  on   0  degrees of freedom
## AIC: 12306
## 
## Number of Fisher Scoring iterations: 8

Recall from Adv ML: - The n << p here is an underdetermined system. There is not a unique solution. - If standard errors of coefficients are very large, which in this case they are, this is not a stable model.

Recall from Regression Classes and Other Course Notes: - Null Deviance is for a model with no predictors; just the intercept. - Null Deviance measures the goodness of fit of a model with no predictors. - ‘$df.null’ is the degrees of freedom for the null model: n-1 observations

pchisq(logreg$null.deviance, logreg$df.null, lower.tail = FALSE)
## [1] 1.735332e-05
# Bad fit in notes had a p-value of 0.9995629 from Ressler
# good fit would be the opposite
pchisq(logreg$deviance, logreg$df.residual, lower.tail = FALSE)
## [1] 0

VIF

# library(car)
# vif_model_lr_model <-vif(lr_model)
# vif_model_logreg <- vif(best_model)

Need to take the first 1000 from the PCA results in Dim 1 to see if it helps some of the issues in modeling

  • They are in order so can simply take first 1000
lr_clr_df %>% 
  select(1:1002) -> lr_clr_df_1000 # because of id column and response column

Logistic with Reduced 1000 ASVs

glmnet::glmnet

1000

L2 regularization

y = as.factor(lr_clr_df_1000$Clade)
x = as.matrix(lr_clr_df_1000[,-c(1,2)])

#glimpse(y)
#dim(x)

library(glmnet)
lr_model_1000 <- glmnet(x, y, 
                        family = "binomial", 
                        #alpha = 1 ,# lasso L1 norm
                        alpha = 0 # ridge L2 norm
                )
lr_model_1000
## 
## Call:  glmnet(x = x, y = y, family = "binomial", alpha = 0) 
## 
##       Df  %Dev  Lambda
## 1   1000  0.00 161.800
## 2   1000  1.13 154.400
## 3   1000  1.18 147.400
## 4   1000  1.23 140.700
## 5   1000  1.29 134.300
## 6   1000  1.35 128.200
## 7   1000  1.41 122.400
## 8   1000  1.47 116.800
## 9   1000  1.54 111.500
## 10  1000  1.61 106.500
## 11  1000  1.68 101.600
## 12  1000  1.75  96.990
## 13  1000  1.83  92.590
## 14  1000  1.91  88.380
## 15  1000  2.00  84.360
## 16  1000  2.08  80.530
## 17  1000  2.18  76.870
## 18  1000  2.27  73.370
## 19  1000  2.37  70.040
## 20  1000  2.47  66.850
## 21  1000  2.58  63.820
## 22  1000  2.69  60.920
## 23  1000  2.81  58.150
## 24  1000  2.93  55.500
## 25  1000  3.05  52.980
## 26  1000  3.18  50.570
## 27  1000  3.32  48.270
## 28  1000  3.46  46.080
## 29  1000  3.60  43.990
## 30  1000  3.75  41.990
## 31  1000  3.91  40.080
## 32  1000  4.07  38.260
## 33  1000  4.23  36.520
## 34  1000  4.41  34.860
## 35  1000  4.59  33.270
## 36  1000  4.77  31.760
## 37  1000  4.96  30.320
## 38  1000  5.16  28.940
## 39  1000  5.37  27.620
## 40  1000  5.58  26.370
## 41  1000  5.80  25.170
## 42  1000  6.02  24.030
## 43  1000  6.26  22.930
## 44  1000  6.50  21.890
## 45  1000  6.75  20.900
## 46  1000  7.00  19.950
## 47  1000  7.26  19.040
## 48  1000  7.54  18.180
## 49  1000  7.82  17.350
## 50  1000  8.10  16.560
## 51  1000  8.40  15.810
## 52  1000  8.70  15.090
## 53  1000  9.02  14.400
## 54  1000  9.34  13.750
## 55  1000  9.67  13.120
## 56  1000 10.01  12.530
## 57  1000 10.36  11.960
## 58  1000 10.71  11.410
## 59  1000 11.08  10.900
## 60  1000 11.45  10.400
## 61  1000 11.84   9.928
## 62  1000 12.23   9.476
## 63  1000 12.63   9.046
## 64  1000 13.04   8.635
## 65  1000 13.46   8.242
## 66  1000 13.89   7.868
## 67  1000 14.33   7.510
## 68  1000 14.74   7.169
## 69  1000 15.20   6.843
## 70  1000 15.66   6.532
## 71  1000 16.13   6.235
## 72  1000 16.61   5.952
## 73  1000 17.10   5.681
## 74  1000 17.60   5.423
## 75  1000 18.11   5.176
## 76  1000 18.63   4.941
## 77  1000 19.15   4.716
## 78  1000 19.68   4.502
## 79  1000 20.22   4.297
## 80  1000 20.77   4.102
## 81  1000 21.32   3.916
## 82  1000 21.89   3.738
## 83  1000 22.46   3.568
## 84  1000 23.03   3.406
## 85  1000 23.62   3.251
## 86  1000 24.21   3.103
## 87  1000 24.80   2.962
## 88  1000 25.40   2.827
## 89  1000 26.01   2.699
## 90  1000 26.63   2.576
## 91  1000 27.24   2.459
## 92  1000 27.87   2.347
## 93  1000 28.49   2.241
## 94  1000 29.13   2.139
## 95  1000 29.76   2.042
## 96  1000 30.40   1.949
## 97  1000 31.05   1.860
## 98  1000 31.69   1.776
## 99  1000 32.34   1.695
## 100 1000 32.99   1.618
summary(lr_model_1000)
##            Length Class     Mode     
## a0            100 -none-    numeric  
## beta       100000 dgCMatrix S4       
## df            100 -none-    numeric  
## dim             2 -none-    numeric  
## lambda        100 -none-    numeric  
## dev.ratio     100 -none-    numeric  
## nulldev         1 -none-    numeric  
## npasses         1 -none-    numeric  
## jerr            1 -none-    numeric  
## offset          1 -none-    logical  
## classnames      2 -none-    character
## call            5 -none-    call     
## nobs            1 -none-    numeric
plot(lr_model_1000)

plot(lr_model_1000, xlim = c(0, .1), ylim = c(-0.02, 0.02))

Cross-Validation

cv_results <- cv.glmnet(x, y,
                        family = "binomial",
                        nfolds = 10)
plot(cv_results)

best_lambda_1000 <- lr_model_1000$lambda.min

# Refit the model with the selected lambda
best_model_1000 <- glmnet(x, y, family = "binomial", alpha = 0, lambda = best_lambda_1000)

coefficients(best_model_1000)[,1:3]
## 1001 x 3 sparse Matrix of class "dgCMatrix"
##                        s0            s1            s2
## (Intercept) -1.249001e-16  9.061144e-07  1.007402e-06
## ASV1236      3.133071e-38  1.929374e-04  2.021068e-04
## ASV0421     -5.547569e-38 -3.442272e-04 -3.605981e-04
## ASV0691     -4.924975e-38 -2.980021e-04 -3.121670e-04
## ASV0899     -1.324028e-39 -2.647790e-06 -2.765069e-06
## ASV1004      6.299724e-38  3.897104e-04  4.082281e-04
## ASV1041     -4.258951e-38 -2.647980e-04 -2.773742e-04
## ASV1058      5.855981e-38  3.627131e-04  3.799159e-04
## ASV12542     1.842670e-38  1.121451e-04  1.174787e-04
## ASV1294      6.764978e-38  4.216432e-04  4.416631e-04
## ASV13113     2.351661e-38  1.510659e-04  1.582506e-04
## ASV1318      5.929751e-38  3.679276e-04  3.853912e-04
## ASV2269     -1.761531e-38 -1.098640e-04 -1.150604e-04
## ASV2542      3.703376e-38  2.354226e-04  2.465969e-04
## ASV2660     -3.447239e-38 -2.126964e-04 -2.227598e-04
## ASV2737     -1.456066e-39 -1.119154e-05 -1.168387e-05
## ASV2840      4.606802e-38  2.831073e-04  2.965189e-04
## ASV3053      2.609821e-39  1.535022e-05  1.608569e-05
## ASV3077      1.430712e-38  8.806575e-05  9.223487e-05
## ASV3134      4.753922e-38  3.039576e-04  3.184156e-04
## ASV3140      2.100119e-38  1.338543e-04  1.401908e-04
## ASV3579      7.918462e-39  5.276151e-05  5.530391e-05
## ASV6119     -1.761531e-38 -1.098637e-04 -1.150433e-04
## ASV7557     -1.761531e-38 -1.098637e-04 -1.150345e-04
## ASV8422      1.007031e-38  5.994817e-05  6.284206e-05
## ASV1086     -5.080525e-39 -3.066641e-05 -3.212233e-05
## ASV1310      3.341700e-38  2.077064e-04  2.175725e-04
## ASV15750    -8.427200e-39 -5.221488e-05 -5.464778e-05
## ASV16905    -1.761531e-38 -1.098635e-04 -1.150313e-04
## ASV2033      3.219968e-38  2.041570e-04  2.138967e-04
## ASV2089      1.201683e-38  7.523457e-05  7.877109e-05
## ASV2127      4.826544e-38  2.987645e-04  3.129340e-04
## ASV2725      5.527505e-38  3.390615e-04  3.551648e-04
## ASV2804     -1.761531e-38 -1.098634e-04 -1.150291e-04
## ASV3075      3.447315e-38  2.140655e-04  2.242392e-04
## ASV3327      3.161305e-38  2.003626e-04  2.099258e-04
## ASV3342      3.467863e-38  2.187734e-04  2.291435e-04
## ASV3532     -3.132836e-38 -1.979555e-04 -2.073123e-04
## ASV3600      3.984828e-38  2.496622e-04  2.615488e-04
## ASV4013      3.390601e-38  2.106453e-04  2.206513e-04
## ASV4136      3.397772e-38  2.089718e-04  2.188498e-04
## ASV4195      1.761531e-38  1.098632e-04  1.150165e-04
## ASV4407     -1.761531e-38 -1.098632e-04 -1.150078e-04
## ASV4717      1.290371e-39  5.281759e-06  5.597077e-06
## ASV6794      1.867634e-38  1.118327e-04  1.171811e-04
## ASV8324     -1.761531e-38 -1.098631e-04 -1.150058e-04
## ASV8981     -5.080524e-39 -3.032750e-05 -3.168601e-05
## ASV9859      1.271657e-38  8.332313e-05  8.734256e-05
## ASV0936     -2.763764e-38 -1.721959e-04 -1.803995e-04
## ASV12683    -2.597726e-39 -1.757830e-05 -1.836433e-05
## ASV1293      4.103429e-38  2.534863e-04  2.654675e-04
## ASV13055    -4.412996e-39 -2.704357e-05 -2.824588e-05
## ASV17063    -1.761531e-38 -1.098629e-04 -1.149906e-04
## ASV2228      1.761531e-38  1.098629e-04  1.149819e-04
## ASV2769     -3.595451e-39 -2.139338e-05 -2.232012e-05
## ASV2803      8.703816e-39  5.137887e-05  5.387847e-05
## ASV2896      2.186891e-38  1.369429e-04  1.434953e-04
## ASV3062      6.184777e-39  4.103651e-05  4.306309e-05
## ASV3107      2.630824e-38  1.655615e-04  1.734509e-04
## ASV3265      5.341940e-38  3.301578e-04  3.457688e-04
## ASV3666     -1.114465e-39 -7.401172e-06 -7.682167e-06
## ASV4497      1.264747e-38  7.828967e-05  8.205491e-05
## ASV6914     -6.022177e-39 -3.861465e-05 -4.038316e-05
## ASV0576     -6.389199e-38 -3.888766e-04 -4.072977e-04
## ASV0673      1.553071e-38  1.017386e-04  1.065713e-04
## ASV0772      1.888544e-38  1.171483e-04  1.227380e-04
## ASV0862     -1.577283e-38 -9.586874e-05 -1.003910e-04
## ASV0898      1.494744e-38  9.664872e-05  1.012547e-04
## ASV0910      3.275872e-38  2.096304e-04  2.196011e-04
## ASV0964     -2.301490e-38 -1.418109e-04 -1.485153e-04
## ASV10059     1.525478e-38  9.836539e-05  1.030853e-04
## ASV10263    -1.761531e-38 -1.098626e-04 -1.150302e-04
## ASV1088      1.737606e-38  1.109894e-04  1.162792e-04
## ASV1101      3.039775e-38  1.900106e-04  1.990098e-04
## ASV1183      1.927595e-38  1.218231e-04  1.275634e-04
## ASV11956     8.034700e-39  4.655131e-05  4.879179e-05
## ASV12774    -2.459980e-39 -1.668451e-05 -1.744149e-05
## ASV1321      7.011807e-39  4.749508e-05  4.980056e-05
## ASV13793    -1.761531e-38 -1.098625e-04 -1.150202e-04
## ASV14482    -1.373377e-39 -1.039061e-05 -1.085186e-05
## ASV15483     1.217911e-38  7.672963e-05  8.042605e-05
## ASV2062      7.731123e-38  4.831722e-04  5.060198e-04
## ASV2132      3.470506e-38  2.197137e-04  2.301998e-04
## ASV2413      5.051081e-38  3.122968e-04  3.270594e-04
## ASV2490      3.356463e-38  2.049034e-04  2.145658e-04
## ASV2594      1.808116e-38  1.123206e-04  1.176550e-04
## ASV2822     -1.761531e-38 -1.098625e-04 -1.150346e-04
## ASV2863      3.096232e-38  1.909330e-04  1.999101e-04
## ASV2910      4.045912e-38  2.486821e-04  2.604969e-04
## ASV2980      1.459677e-38  9.067086e-05  9.492413e-05
## ASV3307      1.761531e-38  1.098624e-04  1.150202e-04
## ASV3474      2.664464e-38  1.703347e-04  1.784590e-04
## ASV3502      5.699692e-38  3.568423e-04  3.737714e-04
## ASV4236      2.952451e-38  1.819339e-04  1.904635e-04
## ASV4842     -9.516024e-39 -6.037248e-05 -6.321923e-05
## ASV4894     -1.761531e-38 -1.098624e-04 -1.150301e-04
## ASV5290      2.150314e-38  1.340244e-04  1.404209e-04
## ASV5501      4.076922e-39  2.517346e-05  2.636410e-05
## ASV5795      1.425114e-38  8.996845e-05  9.425847e-05
## ASV5987     -1.761531e-38 -1.098623e-04 -1.150333e-04
## ASV6267     -1.761531e-38 -1.098623e-04 -1.150246e-04
## ASV6862      3.472093e-38  2.109825e-04  2.209503e-04
## ASV7145      6.514140e-39  3.793720e-05  3.972365e-05
## ASV7673     -1.761531e-38 -1.098623e-04 -1.150224e-04
## ASV7789      5.781709e-39  3.884250e-05  4.074396e-05
## ASV7809     -2.504185e-39 -1.453640e-05 -1.516652e-05
## ASV8002     -1.761531e-38 -1.098622e-04 -1.150154e-04
## ASV8205      1.018531e-38  6.266018e-05  6.568863e-05
## ASV9155     -1.330777e-38 -8.282886e-05 -8.669474e-05
## ASV9221     -2.388223e-39 -1.445874e-05 -1.507178e-05
## ASV9311     -1.761531e-38 -1.098622e-04 -1.150035e-04
## ASV9557     -1.761531e-38 -1.098622e-04 -1.149948e-04
## ASV9936     -1.761531e-38 -1.098622e-04 -1.149861e-04
## ASV1445      3.997197e-38  2.521075e-04  2.641126e-04
## ASV4232      3.338541e-38  2.118500e-04  2.219670e-04
## ASV6479     -8.157800e-40 -1.222256e-06 -1.209065e-06
## ASV0142     -9.010265e-38 -5.539763e-04 -5.801383e-04
## ASV0378     -2.984397e-38 -1.833058e-04 -1.919293e-04
## ASV1122      5.277825e-38  3.329563e-04  3.487725e-04
## ASV0123     -8.831622e-38 -5.428028e-04 -5.683888e-04
## ASV2064      9.456684e-39  5.509733e-05  5.765783e-05
## ASV4459     -9.719539e-39 -6.089954e-05 -6.375611e-05
## ASV0448      1.423142e-38  9.453121e-05  9.909573e-05
## ASV0397      3.967868e-38  2.498767e-04  2.617620e-04
## ASV0485      5.602948e-38  3.488520e-04  3.653669e-04
## ASV1566      4.654943e-38  2.920020e-04  3.058371e-04
## ASV1365      3.010399e-38  1.883007e-04  1.972552e-04
## ASV1065      6.170416e-38  3.879903e-04  4.063513e-04
## ASV0722     -1.470608e-39 -8.356450e-06 -8.764456e-06
## ASV12660    -2.979446e-38 -1.829083e-04 -1.915260e-04
## ASV0223     -1.235827e-39 -7.079307e-06 -7.420103e-06
## ASV0229      2.730513e-38  1.733024e-04  1.815336e-04
## ASV0877     -1.108271e-38 -6.934177e-05 -7.251258e-05
## ASV0983      5.740917e-38  3.565161e-04  3.733500e-04
## ASV0626     -1.988713e-38 -1.177673e-04 -1.231792e-04
## ASV4146     -3.218327e-39 -2.045870e-05 -2.133370e-05
## ASV4175     -3.481381e-38 -2.179938e-04 -2.282376e-04
## ASV2082     -2.075558e-39 -1.466889e-05 -1.550171e-05
## ASV2272      2.490583e-38  1.563717e-04  1.638329e-04
## ASV2245     -3.017452e-38 -1.899536e-04 -1.988646e-04
## ASV0590     -1.761143e-38 -1.141166e-04 -1.196345e-04
## ASV0217     -3.047970e-38 -1.783840e-04 -1.866705e-04
## ASV0416      2.949399e-38  1.783479e-04  1.866963e-04
## ASV1056      3.274151e-38  2.102085e-04  2.203026e-04
## ASV7777     -3.002033e-38 -1.896093e-04 -1.984965e-04
## ASV0455      5.747357e-39  3.770093e-05  3.941339e-05
## ASV0604      5.799389e-39  4.114016e-05  4.321611e-05
## ASV6100     -2.766616e-38 -1.749477e-04 -1.831401e-04
## ASV11359    -3.118370e-38 -1.944198e-04 -2.035125e-04
## ASV6604      2.173846e-38  1.380434e-04  1.446705e-04
## ASV5004     -1.832224e-38 -1.148694e-04 -1.201867e-04
## ASV1483     -1.683076e-38 -1.064335e-04 -1.113709e-04
## ASV9773     -3.550227e-38 -2.238822e-04 -2.343609e-04
## ASV4059      2.938087e-39  2.043102e-05  2.148306e-05
## ASV1193      5.793652e-38  3.635663e-04  3.808316e-04
## ASV4610     -6.006542e-39 -3.289866e-05 -3.435845e-05
## ASV0742     -2.298570e-38 -1.371863e-04 -1.434842e-04
## ASV1502      8.007334e-41 -2.002875e-06 -2.039349e-06
## ASV0195     -5.832160e-39 -3.973575e-05 -4.167975e-05
## ASV1213      1.900259e-38  1.158907e-04  1.211927e-04
## ASV1648     -2.634404e-38 -1.658958e-04 -1.736336e-04
## ASV6984     -1.961126e-38 -1.238836e-04 -1.296297e-04
## ASV0396     -1.668481e-38 -9.270906e-05 -9.704518e-05
## ASV4297      3.047471e-38  1.867070e-04  1.955709e-04
## ASV2622      6.888392e-38  4.255820e-04  4.456766e-04
## ASV3512      9.672295e-39  6.361441e-05  6.675543e-05
## ASV2411      2.270339e-38  1.449659e-04  1.518106e-04
## ASV2291     -5.441058e-39 -3.626678e-05 -3.814461e-05
## ASV0807      2.604318e-38  1.707534e-04  1.789188e-04
## ASV1292      1.555548e-38  9.671461e-05  1.011968e-04
## ASV1035      7.560947e-39  4.445424e-05  4.650978e-05
## ASV0070     -1.712350e-38 -1.021739e-04 -1.069515e-04
## ASV0255      6.544534e-39  4.032696e-05  4.218059e-05
## ASV0057     -7.196267e-38 -4.395095e-04 -4.601513e-04
## ASV0077     -1.116893e-38 -6.528255e-05 -6.830784e-05
## ASV0625      7.103019e-38  4.374509e-04  4.579578e-04
## ASV2464      3.477612e-38  2.120437e-04  2.219744e-04
## ASV1315      5.946957e-38  3.736696e-04  3.914768e-04
## ASV2673      4.308417e-38  2.756272e-04  2.887948e-04
## ASV2161      1.768595e-38  1.138762e-04  1.193504e-04
## ASV0337     -2.931708e-38 -1.832138e-04 -1.919311e-04
## ASV7680     -3.404884e-38 -2.150480e-04 -2.251340e-04
## ASV0611      7.352171e-38  4.662827e-04  4.884546e-04
## ASV3118     -2.500910e-38 -1.589829e-04 -1.664547e-04
## ASV1284      2.644200e-38  1.723854e-04  1.803981e-04
## ASV0889      2.055484e-38  1.272737e-04  1.333347e-04
## ASV4649     -2.121874e-38 -1.338288e-04 -1.400721e-04
## ASV1108     -2.641951e-38 -1.701648e-04 -1.782052e-04
## ASV0738     -5.908183e-39 -2.655865e-05 -2.771101e-05
## ASV0473      4.155210e-39  2.524468e-05  2.639642e-05
## ASV0598     -3.187637e-38 -1.933020e-04 -2.023816e-04
## ASV0429      4.956004e-38  3.099324e-04  3.245709e-04
## ASV1549      4.785423e-38  3.070379e-04  3.216705e-04
## ASV1203      3.731441e-38  2.319491e-04  2.428369e-04
## ASV4532      1.922455e-39  9.565675e-06  1.005106e-05
## ASV0274     -3.852814e-38 -2.334527e-04 -2.444666e-04
## ASV0163     -5.515623e-38 -3.359041e-04 -3.515550e-04
## ASV1298      2.242946e-38  1.362926e-04  1.426131e-04
## ASV9424     -4.497007e-38 -2.851788e-04 -2.985903e-04
## ASV0412      7.043598e-38  4.384212e-04  4.591469e-04
## ASV0284      3.217293e-38  1.964214e-04  2.056085e-04
## ASV0620     -2.264305e-38 -1.472501e-04 -1.541953e-04
## ASV0153     -4.777492e-38 -3.040996e-04 -3.186625e-04
## ASV0498      3.908578e-39  3.282664e-05  3.442643e-05
## ASV0097      3.406348e-38  2.160606e-04  2.263002e-04
## ASV0104     -1.612636e-37 -1.007436e-03 -1.055223e-03
## ASV1282      2.775381e-38  1.784123e-04  1.868989e-04
## ASV3883     -1.582262e-38 -1.016338e-04 -1.064176e-04
## ASV0801      1.543506e-38  1.019392e-04  1.066975e-04
## ASV1611     -6.138811e-38 -3.875729e-04 -4.058371e-04
## ASV0227     -2.145864e-38 -1.390629e-04 -1.457545e-04
## ASV0833      2.307460e-38  1.503799e-04  1.575809e-04
## ASV0718      5.752412e-38  3.611968e-04  3.782723e-04
## ASV1139      2.218115e-38  1.335708e-04  1.397017e-04
## ASV0766     -1.602961e-38 -9.976165e-05 -1.043875e-04
## ASV2091      7.916680e-38  4.835075e-04  5.062491e-04
## ASV1238     -5.836449e-39 -2.502779e-05 -2.610076e-05
## ASV9193     -6.133051e-39 -5.058872e-05 -5.290561e-05
## ASV0290     -5.878822e-39 -3.840336e-05 -4.022656e-05
## ASV0231      6.145335e-38  3.835428e-04  4.015906e-04
## ASV0185      8.140561e-39  6.719574e-05  7.056025e-05
## ASV2330      1.801334e-38  1.112742e-04  1.165388e-04
## ASV3119     -1.890145e-38 -1.254106e-04 -1.314064e-04
## ASV2368     -2.727240e-38 -1.747661e-04 -1.829704e-04
## ASV0122     -2.266189e-38 -1.381388e-04 -1.447139e-04
## ASV1044      3.693122e-38  2.396754e-04  2.511340e-04
## ASV0160     -5.622767e-38 -3.408501e-04 -3.567857e-04
## ASV0326      3.500982e-38  2.200764e-04  2.306143e-04
## ASV1388      6.164818e-38  3.855239e-04  4.037625e-04
## ASV0792      7.055394e-38  4.384047e-04  4.589801e-04
## ASV0036     -4.341619e-38 -2.754152e-04 -2.885896e-04
## ASV2125      7.212501e-38  4.504528e-04  4.717706e-04
## ASV1075      1.338293e-38  8.600306e-05  9.014910e-05
## ASV0390      1.253755e-38  8.409540e-05  8.810937e-05
## ASV3790     -5.735622e-38 -3.606185e-04 -3.776142e-04
## ASV1535     -4.340024e-39 -3.242912e-05 -3.396801e-05
## ASV0263      1.187358e-38  7.485188e-05  7.833070e-05
## ASV0675      9.307161e-38  5.953687e-04  6.235977e-04
## ASV3348      8.656278e-39  5.709178e-05  5.991906e-05
## ASV0058     -9.122278e-38 -5.658057e-04 -5.925354e-04
## ASV4142      2.292079e-38  1.432785e-04  1.499694e-04
## ASV0059     -7.879787e-38 -4.875709e-04 -5.105542e-04
## ASV0013     -1.637259e-37 -1.023254e-03 -1.071668e-03
## ASV0033     -4.719255e-38 -3.000726e-04 -3.143829e-04
## ASV4354     -2.135964e-38 -1.323821e-04 -1.385868e-04
## ASV0022     -4.986826e-38 -3.170200e-04 -3.321039e-04
## ASV0134     -1.193838e-38 -7.855181e-05 -8.232229e-05
## ASV0415     -1.175890e-38 -6.533810e-05 -6.832665e-05
## ASV10103    -3.511087e-38 -2.210616e-04 -2.314332e-04
## ASV1613      5.799264e-38  3.600171e-04  3.769616e-04
## ASV0135     -4.478038e-39 -2.161185e-05 -2.249002e-05
## ASV0469     -7.254312e-38 -4.495635e-04 -4.706218e-04
## ASV0471      4.519901e-38  2.906884e-04  3.043881e-04
## ASV0451     -1.173322e-38 -7.677866e-05 -8.051276e-05
## ASV0747      1.684687e-38  1.115359e-04  1.168645e-04
## ASV1314     -2.604417e-38 -1.685311e-04 -1.765204e-04
## ASV0425     -8.316441e-38 -5.092673e-04 -5.331341e-04
## ASV0559     -4.740023e-38 -2.907009e-04 -3.043054e-04
## ASV0148     -5.151179e-38 -3.133214e-04 -3.279894e-04
## ASV0129     -2.643876e-38 -1.546995e-04 -1.618648e-04
## ASV1072      2.514587e-38  1.498860e-04  1.568862e-04
## ASV2390      1.792174e-38  1.102213e-04  1.154024e-04
## ASV0548      5.195657e-38  3.267256e-04  3.422448e-04
## ASV0168     -7.970435e-38 -4.932037e-04 -5.163699e-04
## ASV0066     -5.880654e-38 -3.680560e-04 -3.854432e-04
## ASV0468     -2.156339e-38 -1.350361e-04 -1.413525e-04
## ASV0172     -1.376210e-38 -7.686478e-05 -8.032894e-05
## ASV0236     -3.246804e-38 -1.897687e-04 -1.984600e-04
## ASV0250     -7.781599e-40  1.006734e-05  1.080241e-05
## ASV0338     -5.609719e-39 -2.574152e-05 -2.678285e-05
## ASV0450     -2.980329e-40 -2.321319e-06 -2.432247e-06
## ASV0377      6.423902e-38  4.027969e-04  4.217977e-04
## ASV1022      1.776651e-38  1.123110e-04  1.175648e-04
## ASV6174     -4.557312e-39 -2.773595e-05 -2.902771e-05
## ASV0786      7.561788e-39  4.524627e-05  4.733565e-05
## ASV0053     -7.710100e-38 -4.860181e-04 -5.089965e-04
## ASV0697     -2.322761e-38 -1.414194e-04 -1.479960e-04
## ASV0785      5.747145e-38  3.583756e-04  3.753128e-04
## ASV1967     -3.902972e-38 -2.391834e-04 -2.504475e-04
## ASV0385     -1.854378e-38 -1.096718e-04 -1.147699e-04
## ASV0295     -1.077806e-39 -6.680155e-07 -5.653973e-07
## ASV0072     -6.300848e-38 -3.860527e-04 -4.040912e-04
## ASV0157     -2.674913e-38 -1.616090e-04 -1.691075e-04
## ASV0501      2.719653e-38  1.783235e-04  1.868629e-04
## ASV10729    -4.667636e-38 -2.955790e-04 -3.095157e-04
## ASV1470      2.276183e-38  1.323368e-04  1.385252e-04
## ASV0050     -1.552864e-37 -9.656828e-04 -1.011108e-03
## ASV0411     -4.571970e-39 -2.486094e-05 -2.595708e-05
## ASV0549      2.846724e-38  1.815512e-04  1.902556e-04
## ASV0184      1.803143e-38  1.133680e-04  1.186896e-04
## ASV0705      2.127130e-38  1.369715e-04  1.434864e-04
## ASV1715      5.451392e-38  3.426063e-04  3.587628e-04
## ASV0603      6.303247e-39  4.100900e-05  4.291892e-05
## ASV0826      1.883618e-38  1.140217e-04  1.193548e-04
## ASV0034     -7.066366e-38 -4.374977e-04 -4.579500e-04
## ASV0838      1.483163e-38  9.444823e-05  9.883824e-05
## ASV0614     -4.004712e-38 -2.492571e-04 -2.609964e-04
## ASV0014     -1.504048e-37 -9.372845e-04 -9.813157e-04
## ASV0585     -9.271648e-39 -5.561584e-05 -5.826175e-05
## ASV0016     -1.536910e-37 -9.582096e-04 -1.003158e-03
## ASV5394     -3.851025e-38 -2.431785e-04 -2.546600e-04
## ASV0666      3.316568e-38  2.065365e-04  2.162012e-04
## ASV2085      1.443304e-38  8.251678e-05  8.620213e-05
## ASV0003     -1.408628e-37 -8.767033e-04 -9.177257e-04
## ASV0346     -4.125123e-39 -1.721872e-05 -1.778535e-05
## ASV0267     -2.302057e-38 -1.416055e-04 -1.480550e-04
## ASV0353      2.834266e-38  1.910644e-04  2.002709e-04
## ASV2419      3.995432e-38  2.473374e-04  2.589040e-04
## ASV0447      1.710637e-38  1.153985e-04  1.210613e-04
## ASV0654      6.042853e-38  3.826604e-04  4.008056e-04
## ASV0151      8.512835e-39  5.792987e-05  6.087313e-05
## ASV0065     -5.669201e-38 -3.511706e-04 -3.676712e-04
## ASV0527      4.097663e-38  2.565767e-04  2.686172e-04
## ASV4055     -1.480477e-38 -9.645305e-05 -1.010584e-04
## ASV0166     -4.804275e-38 -2.890922e-04 -3.025436e-04
## ASV0417     -4.017932e-38 -2.491413e-04 -2.607931e-04
## ASV0078     -3.257390e-38 -1.977389e-04 -2.069215e-04
## ASV0322     -3.965370e-38 -2.380086e-04 -2.490554e-04
## ASV0156     -5.105976e-38 -3.099732e-04 -3.244523e-04
## ASV0648     -4.488601e-38 -2.853578e-04 -2.988298e-04
## ASV0407      3.103441e-39  1.917429e-05  2.013282e-05
## ASV2030     -1.031307e-38 -6.165203e-05 -6.455263e-05
## ASV0300      2.546967e-38  1.691349e-04  1.773020e-04
## ASV1150     -3.852651e-39 -2.250545e-05 -2.347579e-05
## ASV0958      2.664002e-38  1.727893e-04  1.810726e-04
## ASV0216     -4.906846e-38 -3.015358e-04 -3.155102e-04
## ASV0446      6.489840e-38  4.186228e-04  4.385280e-04
## ASV0367     -2.295717e-38 -1.438275e-04 -1.505690e-04
## ASV0200     -4.250453e-38 -2.643891e-04 -2.768377e-04
## ASV0334     -2.377183e-38 -1.387640e-04 -1.449634e-04
## ASV1311      3.031849e-38  1.896086e-04  1.984447e-04
## ASV0458      3.264472e-38  2.027056e-04  2.122837e-04
## ASV1371      9.212320e-40  6.054493e-06  6.356439e-06
## ASV0418      3.956423e-38  2.411444e-04  2.524588e-04
## ASV0004      4.709975e-38  2.926777e-04  3.064609e-04
## ASV1943      3.491045e-38  2.148851e-04  2.250621e-04
## ASV1495     -7.505106e-39 -5.442197e-05 -5.715922e-05
## ASV0901     -5.270082e-38 -3.350038e-04 -3.509117e-04
## ASV0628      3.182044e-38  1.969984e-04  2.061649e-04
## ASV0400      1.272268e-38  8.065696e-05  8.440975e-05
## ASV0116     -4.015755e-38 -2.542553e-04 -2.663371e-04
## ASV0788      3.388298e-38  2.125580e-04  2.225871e-04
## ASV0117      2.104939e-38  1.357842e-04  1.423066e-04
## ASV3137      6.088051e-39  3.848299e-05  4.029869e-05
## ASV0001      5.769339e-38  3.536812e-04  3.701227e-04
## ASV1651      3.849282e-38  2.335887e-04  2.444161e-04
## ASV1692      3.916604e-38  2.504420e-04  2.623838e-04
## ASV0660      2.398237e-38  1.458939e-04  1.525745e-04
## ASV0508      3.230712e-39  1.738897e-05  1.818771e-05
## ASV1660     -1.583265e-38 -1.029841e-04 -1.079352e-04
## ASV0233      8.806217e-39  5.556732e-05  5.825810e-05
## ASV1343     -4.010104e-38 -2.536869e-04 -2.656777e-04
## ASV0209      3.847575e-38  2.369220e-04  2.479013e-04
## ASV0193     -4.956363e-38 -2.989608e-04 -3.128243e-04
## ASV0357     -3.708285e-39 -2.040575e-05 -2.122741e-05
## ASV0198      1.029473e-38  6.738208e-05  7.056704e-05
## ASV0007      5.469502e-38  3.352941e-04  3.508548e-04
## ASV1772     -5.550091e-39 -3.369084e-05 -3.525756e-05
## ASV0009      5.167512e-38  3.163593e-04  3.310047e-04
## ASV0006      2.157679e-38  1.287100e-04  1.345301e-04
## ASV0011     -5.581552e-38 -3.539176e-04 -3.706337e-04
## ASV0015      3.953436e-38  2.458156e-04  2.573752e-04
## ASV0017      4.193162e-38  2.603749e-04  2.725782e-04
## ASV0235     -3.262141e-38 -2.080464e-04 -2.178794e-04
## ASV0382      4.625552e-39  3.761896e-05  3.963913e-05
## ASV2357      4.986866e-38  3.147353e-04  3.295625e-04
## ASV0567     -3.682815e-38 -2.273657e-04 -2.379658e-04
## ASV0165      3.988685e-38  2.524107e-04  2.643067e-04
## ASV0005      8.107507e-38  5.030376e-04  5.265366e-04
## ASV0384     -4.532717e-39 -2.391229e-05 -2.488721e-05
## ASV0002      1.659396e-38  1.056060e-04  1.106816e-04
## ASV3017      4.757079e-38  2.941134e-04  3.077482e-04
## ASV0091      1.764900e-38  1.126809e-04  1.180262e-04
## ASV0186     -4.797272e-38 -3.025173e-04 -3.167599e-04
## ASV0370      4.710406e-39  3.242822e-05  3.393046e-05
## ASV0018      8.430121e-38  5.238270e-04  5.482902e-04
## ASV1377      7.378245e-38  4.584754e-04  4.798647e-04
## ASV0019      8.439473e-38  5.246096e-04  5.490704e-04
## ASV0023      7.066716e-39  3.811689e-05  3.961536e-05
## ASV2194      2.682544e-38  1.657151e-04  1.735858e-04
## ASV1155     -3.632665e-39 -2.045096e-05 -2.112931e-05
## ASV0510     -3.222010e-38 -1.914614e-04 -2.000538e-04
## ASV2371     -3.120574e-38 -1.883330e-04 -1.971794e-04
## ASV0024      3.056467e-39  1.289947e-05  1.321128e-05
## ASV2452      4.023230e-38  2.464781e-04  2.577982e-04
## ASV2332      7.898870e-40  7.980271e-06  8.380198e-06
## ASV2591      5.921995e-40  1.114325e-05  1.169059e-05
## ASV0521      5.271635e-38  3.376747e-04  3.537124e-04
## ASV5542      1.600784e-38  1.044758e-04  1.093317e-04
## ASV0336     -2.531440e-38 -1.521655e-04 -1.592651e-04
## ASV10102     3.682342e-38  2.345592e-04  2.455933e-04
## ASV16823    -3.040027e-38 -1.833438e-04 -1.919754e-04
## ASV3104      3.040027e-38  1.833438e-04  1.919608e-04
## ASV0781      1.428856e-38  9.034102e-05  9.450487e-05
## ASV10899     1.253085e-38  8.505534e-05  8.915119e-05
## ASV11222    -3.040027e-38 -1.833438e-04 -1.919508e-04
## ASV11327    -3.040027e-38 -1.833438e-04 -1.919363e-04
## ASV12458    -3.040027e-38 -1.833437e-04 -1.919218e-04
## ASV1636     -2.490636e-38 -1.502776e-04 -1.572064e-04
## ASV1890     -3.007323e-38 -1.826902e-04 -1.912514e-04
## ASV2898      6.377943e-38  3.963772e-04  4.148268e-04
## ASV8328     -6.226076e-39 -3.050376e-05 -3.180798e-05
## ASV0709     -5.198536e-38 -3.241989e-04 -3.392523e-04
## ASV0856      7.771543e-39  5.185754e-05  5.434010e-05
## ASV0909     -2.335561e-38 -1.373596e-04 -1.434471e-04
## ASV0937     -4.008191e-38 -2.512158e-04 -2.631328e-04
## ASV11390    -3.040027e-38 -1.833437e-04 -1.918906e-04
## ASV11966     1.420327e-38  9.362239e-05  9.808893e-05
## ASV12990     7.819545e-39  5.097148e-05  5.329142e-05
## ASV14797     3.089629e-38  1.916429e-04  2.004407e-04
## ASV14904    -3.040027e-38 -1.833437e-04 -1.918861e-04
## ASV15304     7.030854e-39  4.959226e-05  5.199614e-05
## ASV16696    -3.040027e-38 -1.833437e-04 -1.918741e-04
## ASV1690      1.419706e-38  9.474152e-05  9.931727e-05
## ASV2029      8.151639e-38  5.078098e-04  5.314942e-04
## ASV2834      4.329441e-38  2.718513e-04  2.846539e-04
## ASV4003      1.121142e-38  7.786970e-05  8.167422e-05
## ASV4064      2.989265e-38  1.881080e-04  1.969629e-04
## ASV4294      9.589711e-39  6.672512e-05  6.997953e-05
## ASV4609     -1.530065e-39 -7.762320e-06 -8.186518e-06
## ASV6283     -3.040027e-38 -1.833436e-04 -1.918711e-04
## ASV6491     -3.040027e-38 -1.833436e-04 -1.918567e-04
## ASV7453      1.059821e-38  7.257786e-05  7.611077e-05
## ASV7959      1.319226e-39  1.437688e-05  1.514588e-05
## ASV8219      3.040027e-38  1.833436e-04  1.918463e-04
## ASV8547     -3.040027e-38 -1.833435e-04 -1.918319e-04
## ASV9319      1.938115e-38  1.249180e-04  1.307920e-04
## ASV9382     -3.040027e-38 -1.833435e-04 -1.918230e-04
## ASV11516    -3.040027e-38 -1.833435e-04 -1.918087e-04
## ASV14377    -3.040027e-38 -1.833435e-04 -1.917944e-04
## ASV1867      4.243133e-38  2.690179e-04  2.817094e-04
## ASV1895     -1.045979e-38 -6.238056e-05 -6.521034e-05
## ASV3168      1.850837e-38  1.157063e-04  1.210261e-04
## ASV4449      3.739630e-38  2.283226e-04  2.389149e-04
## ASV6596      1.994017e-38  1.316258e-04  1.379958e-04
## ASV7492     -1.214220e-38 -6.847593e-05 -7.148297e-05
## ASV9854     -1.586802e-38 -9.386466e-05 -9.816982e-05
## ASV6296      3.040027e-38  1.833434e-04  1.917640e-04
## ASV4201      8.213575e-39  6.014103e-05  6.323409e-05
## ASV0552      7.091608e-38  4.516360e-04  4.730122e-04
## ASV3671     -6.933592e-39 -3.719823e-05 -3.879673e-05
## ASV3529     -7.618069e-39 -4.027942e-05 -4.195133e-05
## ASV1060      1.780419e-38  1.123890e-04  1.177293e-04
## ASV0239     -4.212994e-38 -2.568408e-04 -2.686115e-04
## ASV5711     -3.858562e-38 -2.356699e-04 -2.465581e-04
## ASV4152     -5.028716e-38 -3.101244e-04 -3.245655e-04
## ASV1461      4.545945e-38  2.794286e-04  2.922381e-04
## ASV2877      3.640261e-38  2.260808e-04  2.366048e-04
## ASV0012      2.642182e-38  1.681247e-04  1.761872e-04
## ASV9823      1.022522e-38  5.491223e-05  5.737961e-05
## ASV0008      2.903262e-38  1.838244e-04  1.925860e-04
## ASV7832     -3.117744e-38 -1.918865e-04 -2.007856e-04
## ASV1915      1.884721e-39  1.555624e-05  1.640000e-05
## ASV0055      2.110467e-38  1.309606e-04  1.370952e-04
## ASV0032      5.174495e-38  3.212870e-04  3.361508e-04
## ASV2977     -4.236458e-38 -2.605542e-04 -2.726631e-04
## ASV0466      4.341784e-38  2.647160e-04  2.768930e-04
## ASV3866      4.428837e-38  2.799932e-04  2.931906e-04
## ASV0040      5.852469e-38  3.702257e-04  3.877686e-04
## ASV0496     -2.206917e-39 -2.048367e-05 -2.167057e-05
## ASV0052      7.282631e-38  4.549140e-04  4.761115e-04
## ASV3828     -4.522951e-38 -2.794751e-04 -2.924379e-04
## ASV1930      2.768340e-38  1.755397e-04  1.837902e-04
## ASV2126      4.533398e-38  2.832972e-04  2.965258e-04
## ASV0793      2.607435e-38  1.681727e-04  1.762983e-04
## ASV0299     -2.003054e-38 -1.209158e-04 -1.263369e-04
## ASV0208      4.123216e-38  2.660708e-04  2.787463e-04
## ASV0511     -2.426196e-38 -1.458480e-04 -1.523633e-04
## ASV1123     -3.131395e-38 -1.900407e-04 -1.986913e-04
## ASV0099     -1.685390e-38 -1.015966e-04 -1.062961e-04
## ASV0752     -2.883957e-39 -2.217720e-05 -2.332035e-05
## ASV0883      1.221272e-40  2.648836e-06  2.819829e-06
## ASV0683      3.687287e-38  2.360612e-04  2.472954e-04
## ASV4117     -4.545179e-38 -2.803153e-04 -2.933309e-04
## ASV2172      1.665364e-38  1.049916e-04  1.099263e-04
## ASV0330     -3.022947e-38 -1.878925e-04 -1.967340e-04
## ASV0728      2.813973e-38  1.793898e-04  1.879406e-04
## ASV0499      5.569071e-38  3.563560e-04  3.733098e-04
## ASV0120     -6.313502e-38 -3.958296e-04 -4.143504e-04
## ASV1446      6.044190e-39  3.285861e-05  3.423495e-05
## ASV17171    -4.305784e-38 -2.663911e-04 -2.787829e-04
## ASV0533      1.169723e-38  7.597339e-05  7.962429e-05
## ASV2495     -1.703725e-38 -1.080509e-04 -1.131807e-04
## ASV5582      1.573573e-38  9.440387e-05  9.865464e-05
## ASV1488      1.333731e-38  9.411052e-05  9.859292e-05
## ASV0682      3.878487e-38  2.493205e-04  2.611769e-04
## ASV0068     -1.569197e-39 -1.281555e-05 -1.359875e-05
## ASV1987     -2.040273e-38 -1.346534e-04 -1.411786e-04
## ASV0035      8.741778e-39  4.928184e-05  5.129493e-05
## ASV7192     -2.954758e-38 -1.797012e-04 -1.879473e-04
## ASV0873      4.983130e-39  2.705754e-05  2.817059e-05
## ASV4749      3.649700e-39  1.664750e-05  1.713929e-05
## ASV2174      2.827707e-38  1.648899e-04  1.723791e-04
## ASV1476     -2.364743e-38 -1.468897e-04 -1.537905e-04
## ASV0740     -5.655336e-38 -3.602337e-04 -3.773454e-04
## ASV0170      1.225668e-38  7.630042e-05  7.987677e-05
## ASV2466     -5.252633e-38 -3.277083e-04 -3.430180e-04
## ASV1709      4.103967e-38  2.537808e-04  2.655716e-04
## ASV6170     -3.701779e-38 -2.148484e-04 -2.249753e-04
## ASV3673      4.233390e-38  2.555865e-04  2.676382e-04
## ASV1745      3.214905e-39  1.354176e-05  1.418283e-05
## ASV0380     -3.001704e-38 -1.696603e-04 -1.776105e-04
## ASV0426     -9.429897e-39 -5.381484e-05 -5.639556e-05
## ASV0202     -1.061039e-38 -5.643793e-05 -5.866934e-05
## ASV6350     -3.682451e-38 -2.138252e-04 -2.238667e-04
## ASV0713     -2.510054e-38 -1.577558e-04 -1.651844e-04
## ASV1822      4.504880e-39  3.367713e-05  3.521687e-05
## ASV4569      4.087268e-38  2.504265e-04  2.621259e-04
## ASV0030     -8.372670e-39 -5.693517e-05 -5.977070e-05
## ASV0331      1.553491e-38  1.027274e-04  1.076756e-04
## ASV2981      3.971736e-38  2.557381e-04  2.678093e-04
## ASV0828     -2.616058e-38 -1.702620e-04 -1.783508e-04
## ASV2440      6.289782e-38  4.012742e-04  4.202426e-04
## ASV3006     -3.040027e-38 -1.722930e-04 -1.803573e-04
## ASV3875     -3.040027e-38 -1.722928e-04 -1.803438e-04
## ASV4511      1.544893e-38  9.977457e-05  1.045386e-04
## ASV4700     -3.040027e-38 -1.722927e-04 -1.803305e-04
## ASV5804     -3.040027e-38 -1.722926e-04 -1.803170e-04
## ASV6826      2.879466e-38  1.849621e-04  1.937316e-04
## ASV7280      2.393345e-38  1.596199e-04  1.671595e-04
## ASV7535     -3.040027e-38 -1.722925e-04 -1.803098e-04
## ASV0651     -2.961384e-38 -1.814351e-04 -1.897215e-04
## ASV0913      3.794294e-38  2.416629e-04  2.531138e-04
## ASV10832    -3.040027e-38 -1.722924e-04 -1.802970e-04
## ASV1117     -5.631066e-38 -3.460411e-04 -3.622954e-04
## ASV11329     1.146426e-38  8.543120e-05  8.963651e-05
## ASV13209    -3.629118e-39 -8.176461e-06 -8.471091e-06
## ASV1345      6.318447e-39  4.720438e-05  4.950723e-05
## ASV1719     -3.040027e-38 -1.722921e-04 -1.802759e-04
## ASV1886      3.242222e-38  1.973973e-04  2.066096e-04
## ASV2158     -9.398753e-39 -4.345148e-05 -4.535650e-05
## ASV2189      3.410635e-38  2.126351e-04  2.226309e-04
## ASV2257      2.584074e-38  1.579079e-04  1.653766e-04
## ASV2283      3.040027e-38  1.722918e-04  1.802471e-04
## ASV2328      3.040027e-38  1.722917e-04  1.802338e-04
## ASV2434     -4.282884e-38 -2.568734e-04 -2.688928e-04
## ASV2648      3.040027e-38  1.722915e-04  1.802054e-04
## ASV2698      3.969934e-38  2.495756e-04  2.613377e-04
## ASV2775      5.017817e-38  3.013682e-04  3.152050e-04
## ASV3171      3.040027e-38  1.722913e-04  1.801785e-04
## ASV3227      3.740920e-38  2.236891e-04  2.338985e-04
## ASV3397      1.862479e-39  1.790574e-05  1.886333e-05
## ASV3444      4.180246e-38  2.482199e-04  2.597446e-04
## ASV3556      3.040027e-38  1.722911e-04  1.801450e-04
## ASV3606     -3.040027e-38 -1.722909e-04 -1.801319e-04
## ASV4190      3.521442e-38  2.206988e-04  2.311147e-04
## ASV4197      4.290482e-38  2.563513e-04  2.682446e-04
## ASV4722      3.727856e-38  2.302739e-04  2.410460e-04
## ASV4765      8.670616e-39  6.017957e-05  6.298733e-05
## ASV4809      3.040027e-38  1.722907e-04  1.800997e-04
## ASV4846      2.572609e-38  1.641477e-04  1.718400e-04
## ASV4903     -9.356722e-39 -4.349163e-05 -4.533343e-05
## ASV4944     -3.040027e-38 -1.722904e-04 -1.800863e-04
## ASV5151     -8.791479e-39 -6.825671e-05 -7.171519e-05
## ASV5413     -3.040027e-38 -1.722902e-04 -1.800764e-04
## ASV5537     -3.040027e-38 -1.722901e-04 -1.800634e-04
## ASV5688      3.040027e-38  1.722899e-04  1.800505e-04
## ASV5752      1.243878e-38  8.664077e-05  9.090627e-05
## ASV6122     -3.040027e-38 -1.722898e-04 -1.800408e-04
## ASV6135      3.040027e-38  1.722896e-04  1.800279e-04
## ASV6188     -3.040027e-38 -1.722895e-04 -1.800150e-04
## ASV6216      4.291012e-38  2.560754e-04  2.678352e-04
## ASV6242      3.040027e-38  1.722892e-04  1.799879e-04
## ASV6383      3.040027e-38  1.722891e-04  1.799751e-04
## ASV6781      3.040027e-38  1.722889e-04  1.799622e-04
## ASV6799     -3.040027e-38 -1.722888e-04 -1.799494e-04
## ASV7374     -3.040027e-38 -1.722886e-04 -1.799366e-04
## ASV7539     -3.040027e-38 -1.722885e-04 -1.799239e-04
## ASV8591     -3.040027e-38 -1.722883e-04 -1.799111e-04
## ASV8637      3.040027e-38  1.722882e-04  1.798984e-04
## ASV12796    -3.040027e-38 -1.722880e-04 -1.798857e-04
## ASV1934      3.168520e-38  1.996893e-04  2.090798e-04
## ASV22549    -2.606906e-40  1.244300e-05  1.342050e-05
## ASV29857    -3.040027e-38 -1.722878e-04 -1.798734e-04
## ASV3215      3.810256e-38  2.428910e-04  2.544305e-04
## ASV3236     -3.040027e-38 -1.722877e-04 -1.798599e-04
## ASV3954     -3.040027e-38 -1.722875e-04 -1.798473e-04
## ASV4850      3.040027e-38  1.722874e-04  1.798346e-04
## ASV5225      3.040027e-38  1.722872e-04  1.798220e-04
## ASV5532     -3.040027e-38 -1.722870e-04 -1.798094e-04
## ASV7258      7.356746e-40  2.096691e-05  2.247931e-05
## ASV9474     -1.829704e-38 -9.671518e-05 -1.007003e-04
## ASV11857    -3.040027e-38 -1.722867e-04 -1.797924e-04
## ASV1202     -3.040027e-38 -1.722865e-04 -1.797798e-04
## ASV14742     1.797837e-38  1.229611e-04  1.290531e-04
## ASV16652     9.184402e-39  6.447254e-05  6.775274e-05
## ASV2019      4.207641e-38  2.538784e-04  2.654616e-04
## ASV2410     -3.812021e-38 -2.364654e-04 -2.474735e-04
## ASV2718      3.875721e-38  2.513306e-04  2.633536e-04
## ASV2738      4.796396e-38  2.869577e-04  2.999199e-04
## ASV2876      3.040027e-38  1.722862e-04  1.797522e-04
## ASV3177      3.040027e-38  1.722861e-04  1.797397e-04
## ASV4367      3.040027e-38  1.722859e-04  1.797273e-04
## ASV4635      7.220246e-39  6.014443e-05  6.345972e-05
## ASV4896     -4.249857e-40  1.424251e-05  1.549670e-05
## ASV4907      1.825889e-38  1.282709e-04  1.348030e-04
## ASV5230     -3.040027e-38 -1.722855e-04 -1.797265e-04
## ASV6509     -3.040027e-38 -1.722854e-04 -1.797140e-04
## ASV7376     -3.040027e-38 -1.722852e-04 -1.797016e-04
## ASV8163     -3.040027e-38 -1.722851e-04 -1.796893e-04
## ASV8195     -3.040027e-38 -1.722849e-04 -1.796769e-04
## ASV8923      1.564948e-38  1.068608e-04  1.121893e-04
## ASV9666     -2.728745e-38 -1.524889e-04 -1.589364e-04
## ASV1482      2.477237e-38  1.599956e-04  1.676645e-04
## ASV2726      3.190156e-38  2.073437e-04  2.173428e-04
## ASV3281     -3.040027e-38 -1.722846e-04 -1.796637e-04
## ASV4235     -3.040027e-38 -1.722844e-04 -1.796514e-04
## ASV4808      4.286934e-38  2.576208e-04  2.692390e-04
## ASV4861     -4.283689e-38 -2.569623e-04 -2.685200e-04
## ASV5276      4.241240e-38  2.547652e-04  2.662252e-04
## ASV5837      3.436592e-38  2.171136e-04  2.273516e-04
## ASV7098      3.525946e-38  2.218694e-04  2.322815e-04
## ASV8451     -3.040027e-38 -1.722841e-04 -1.795945e-04
## ASV8694     -3.040027e-38 -1.722839e-04 -1.795823e-04
## ASV0905     -1.429364e-38 -9.329624e-05 -9.778933e-05
## ASV2900      3.647573e-38  2.115027e-04  2.206631e-04
## ASV3963     -2.964512e-38 -1.674774e-04 -1.745248e-04
## ASV0041     -2.938907e-38 -1.910150e-04 -2.002855e-04
## ASV1865      2.859714e-38  1.922027e-04  2.017124e-04
## ASV1140      2.402015e-38  1.578750e-04  1.655903e-04
## ASV1179      3.553674e-38  2.266164e-04  2.373775e-04
## ASV0279      5.181018e-38  3.191382e-04  3.338870e-04
## ASV0043     -3.287927e-39 -2.728768e-05 -2.889292e-05
## ASV2097     -2.989356e-38 -1.778832e-04 -1.857662e-04
## ASV0309     -1.502889e-38 -8.951054e-05 -9.360783e-05
## ASV0607      6.090462e-38  3.872183e-04  4.054829e-04
## ASV0025     -6.402158e-38 -4.094505e-04 -4.289748e-04
## ASV2284     -1.239649e-38 -6.594964e-05 -6.885114e-05
## ASV0556      9.864971e-39  6.962951e-05  7.304822e-05
## ASV5040      2.597255e-38  1.442643e-04  1.502158e-04
## ASV2924     -2.753971e-38 -1.545292e-04 -1.609669e-04
## ASV1331      7.975941e-38  4.979844e-04  5.212729e-04
## ASV0506     -3.805681e-38 -2.275302e-04 -2.379983e-04
## ASV1514      5.945817e-38  3.735752e-04  3.911120e-04
## ASV2144      5.053533e-38  3.144253e-04  3.290924e-04
## ASV2265      6.654328e-38  4.172105e-04  4.367897e-04
## ASV5156      1.612468e-38  9.050394e-05  9.453452e-05
## ASV5534      1.360131e-38  7.326034e-05  7.643030e-05
## ASV5747      1.579865e-53 -1.311884e-05 -1.399834e-05
## ASV6657      3.123704e-38  1.887069e-04  1.974487e-04
## ASV0658     -3.561795e-38 -2.126849e-04 -2.224277e-04
## ASV0716      8.915064e-39  5.403155e-05  5.644381e-05
## ASV1657      1.640683e-38  9.144010e-05  9.544791e-05
## ASV1885      1.244497e-39 -4.291161e-06 -4.758734e-06
## ASV2333      7.434581e-38  4.592082e-04  4.805076e-04
## ASV3375      2.871737e-38  1.702679e-04  1.780091e-04
## ASV4317      2.845844e-38  1.779640e-04  1.863704e-04
## ASV9599      1.711521e-53 -1.311889e-05 -1.404799e-05
## ASV0175     -9.990573e-38 -6.177458e-04 -6.462303e-04
## ASV1032      3.091395e-38  1.831722e-04  1.914487e-04
## ASV1235      2.238318e-39  5.793455e-06  5.792628e-06
## ASV1262      8.755772e-38  5.435277e-04  5.687207e-04
## ASV1320      1.948659e-38  1.322433e-04  1.387505e-04
## ASV13797     3.306856e-38  2.007726e-04  2.100250e-04
## ASV1491      1.460350e-38  1.030255e-04  1.081789e-04
## ASV15014     1.711521e-53 -1.311894e-05 -1.406872e-05
## ASV1510      2.481019e-38  1.644460e-04  1.723766e-04
## ASV1551     -1.104080e-38 -6.736372e-05 -7.044861e-05
## ASV1919     -3.858843e-39 -1.117030e-05 -1.137920e-05
## ASV2114      1.713869e-38  9.916048e-05  1.036132e-04
## ASV21486     1.711521e-53 -1.311898e-05 -1.406351e-05
## ASV2448      4.569306e-38  2.781553e-04  2.909380e-04
## ASV2589      2.237777e-38  1.324460e-04  1.384649e-04
## ASV2608      3.614853e-38  2.214876e-04  2.317430e-04
## ASV2786      2.875533e-38  1.772234e-04  1.854551e-04
## ASV2827      3.773243e-38  2.325524e-04  2.433649e-04
## ASV2872      3.188979e-38  1.896524e-04  1.982353e-04
## ASV3125      3.747887e-38  2.248794e-04  2.350891e-04
## ASV3247      4.057156e-38  2.448711e-04  2.560190e-04
## ASV3451      1.711521e-53 -1.311904e-05 -1.413441e-05
## ASV3465     -2.469012e-39 -2.772178e-05 -2.936067e-05
## ASV3809      2.403302e-38  1.416377e-04  1.479369e-04
## ASV4006      5.058067e-38  3.053694e-04  3.192106e-04
## ASV4046      3.617860e-38  2.168035e-04  2.265832e-04
## ASV4938     -2.155665e-40 -1.448971e-05 -1.559394e-05
## ASV5435      1.711521e-53 -1.311911e-05 -1.415703e-05
## ASV5605      1.609979e-38  8.976807e-05  9.363352e-05
## ASV5635      1.711521e-53 -1.311914e-05 -1.416081e-05
## ASV5743      4.497092e-38  2.737182e-04  2.862712e-04
## ASV6627      1.711521e-53 -1.311916e-05 -1.417318e-05
## ASV6785      1.711521e-53 -1.311918e-05 -1.417140e-05
## ASV7368      4.761317e-38  2.972209e-04  3.110812e-04
## ASV9118      1.508129e-38  8.440220e-05  8.801723e-05
## ASV9135      1.247077e-38  6.632859e-05  6.903961e-05
## ASV9435      2.510395e-38  1.448377e-04  1.511676e-04
## ASV9671      1.579865e-53 -1.311923e-05 -1.419412e-05
## ASV0387     -5.040080e-38 -3.037061e-04 -3.174984e-04
## ASV0454     -4.962213e-38 -3.017893e-04 -3.155977e-04
## ASV0751     -3.309851e-38 -1.977330e-04 -2.066223e-04
## ASV1081      1.277394e-38  8.087499e-05  8.471762e-05
## ASV1332      2.670614e-38  1.647321e-04  1.723421e-04
## ASV2659      4.138730e-38  2.618769e-04  2.741672e-04
## ASV2979      4.574727e-38  2.746782e-04  2.870286e-04
## ASV4184      2.022738e-38  1.128542e-04  1.176046e-04
## ASV6198      1.634206e-38  9.655324e-05  1.008647e-04
## ASV7454      2.972525e-38  1.785556e-04  1.866058e-04
## ASV8198      1.381746e-38  7.328811e-05  7.619563e-05
## ASV0855      6.318760e-38  3.954832e-04  4.139411e-04
## ASV10092     2.818463e-38  1.689544e-04  1.765583e-04
## ASV1532      3.358332e-38  2.169000e-04  2.272754e-04
## ASV2553      8.400286e-38  5.251392e-04  5.496222e-04
## ASV2741      3.236422e-38  2.108671e-04  2.210488e-04
## ASV4095      1.650114e-38  1.144302e-04  1.202262e-04
## ASV5295      2.695222e-38  1.560140e-04  1.628012e-04
## ASV5787      1.711521e-53 -1.311936e-05 -1.424539e-05
## ASV9455      3.404879e-38  2.054058e-04  2.146439e-04
## ASV10879     3.459155e-38  2.124244e-04  2.221745e-04
## ASV3997      2.228766e-38  1.466766e-04  1.537860e-04
## ASV6760      9.272111e-39  4.405984e-05  4.555901e-05
## ASV6990      2.610804e-38  1.547260e-04  1.615858e-04
## ASV9560      1.690264e-38  9.678748e-05  1.009320e-04
## ASV0220      1.372524e-38  8.677118e-05  9.093000e-05
## ASV2518      3.270863e-38  2.066836e-04  2.163895e-04
## ASV3615      5.255024e-38  3.244373e-04  3.393609e-04
## ASV0075      1.248383e-38  7.550417e-05  7.890928e-05
## ASV8070      8.545617e-39  4.102726e-05  4.241214e-05
## ASV1658      2.564588e-38  1.544552e-04  1.614312e-04
## ASV0773      4.147203e-38  2.529263e-04  2.644739e-04
## ASV0799      1.308621e-39  8.871714e-06  9.256701e-06
## ASV1839     -9.031958e-39 -5.252963e-05 -5.484532e-05
## ASV0265      3.621898e-38  2.391929e-04  2.509005e-04
## ASV3741      1.552936e-38  9.436252e-05  9.867998e-05
## ASV0847      5.380913e-38  3.355617e-04  3.512454e-04
## ASV1026      5.791672e-38  3.596241e-04  3.762813e-04
## ASV1222     -2.006763e-38 -1.125936e-04 -1.172658e-04
## ASV0729      7.995788e-39  5.045008e-05  5.283444e-05
## ASV0143     -4.554584e-38 -2.755652e-04 -2.880105e-04
## ASV1328      1.197601e-38  7.958800e-05  8.353390e-05
## ASV9078     -8.638951e-39 -6.808722e-05 -7.187410e-05
## ASV0027     -6.129045e-38 -3.916043e-04 -4.102290e-04
## ASV0546     -2.867009e-38 -1.714904e-04 -1.791583e-04
## ASV1136      7.053137e-38  4.373300e-04  4.575328e-04
## ASV3081      3.320036e-38  2.065641e-04  2.161614e-04
## ASV0531      1.394782e-38  9.201229e-05  9.656765e-05
## ASV2525      1.990986e-38  1.211271e-04  1.265624e-04
## ASV1083     -8.493520e-39 -4.482344e-05 -4.654032e-05
## ASV0424      1.227119e-38  7.556593e-05  7.909195e-05
## ASV0644     -1.733463e-53  1.078556e-05  1.175166e-05
## ASV6007      1.492095e-53 -1.278890e-05 -1.395787e-05
## ASV0564      1.585796e-38  1.064864e-04  1.117949e-04
## ASV1938      2.007382e-38  1.157617e-04  1.207125e-04
## ASV6516     -4.277777e-38 -2.664826e-04 -2.788734e-04
## ASV0503     -5.241223e-38 -3.135084e-04 -3.274573e-04
## ASV6913     -5.220210e-38 -3.170393e-04 -3.313793e-04
## ASV0164     -3.805648e-38 -2.431961e-04 -2.547229e-04
## ASV1576      4.761563e-38  2.955914e-04  3.092526e-04
## ASV1725      2.125365e-38  1.439689e-04  1.511718e-04
## ASV4501      2.183865e-38  1.258433e-04  1.311842e-04
## ASV10678    -4.213446e-38 -2.618532e-04 -2.739879e-04
## ASV0944      3.325204e-38  2.130455e-04  2.231876e-04
## ASV2292      5.476757e-38  3.369694e-04  3.524384e-04
## ASV1090      3.521312e-38  2.193343e-04  2.294440e-04
## ASV9117     -1.897843e-38 -1.067065e-04 -1.111374e-04
## ASV0285     -1.878554e-38 -1.309412e-04 -1.376330e-04
## ASV0463     -3.568047e-38 -2.146018e-04 -2.241740e-04
## ASV3199      3.134678e-38  1.861376e-04  1.943390e-04
## ASV0150     -1.103024e-38 -7.491271e-05 -7.866313e-05
## ASV6583     -1.892061e-38 -1.076607e-04 -1.121700e-04
## ASV0392      2.792587e-38  1.737663e-04  1.818185e-04
## ASV14007    -3.459648e-38 -2.120739e-04 -2.217904e-04
## ASV0177     -1.987566e-38 -1.177432e-04 -1.228672e-04
## ASV6448     -1.213724e-38 -8.993383e-05 -9.479157e-05
## ASV5399     -3.657760e-39 -3.558434e-05 -3.784392e-05
## ASV0277     -6.815782e-39 -4.350637e-05 -4.558269e-05
## ASV2599      1.458945e-38  8.080945e-05  8.410876e-05
## ASV13465    -1.217653e-38 -6.461883e-05 -6.715383e-05
## ASV2412      1.749340e-38  1.099724e-04  1.151048e-04
## ASV0423      3.278161e-38  2.133763e-04  2.237138e-04
## ASV5187      2.373825e-38  1.341847e-04  1.398055e-04
## ASV0701     -8.100065e-38 -5.131620e-04 -5.373714e-04
## ASV4248      1.808802e-38  1.235621e-04  1.298019e-04
## ASV0519      3.303489e-38  2.135701e-04  2.238092e-04
## ASV0764      4.817093e-39  3.511310e-05  3.696097e-05
## ASV5385     -4.230483e-38 -2.674728e-04 -2.800790e-04
## ASV3021     -2.693519e-38 -1.563961e-04 -1.631722e-04
## ASV4119     -1.533501e-38 -8.639857e-05 -8.998193e-05
## ASV2534      7.307864e-39  4.185665e-05  4.357858e-05
## ASV1061      2.986485e-38  2.006349e-04  2.105983e-04
## ASV0670      4.508419e-38  2.856840e-04  2.991687e-04
## ASV1384      1.797613e-38  1.220610e-04  1.281894e-04
## ASV1981      4.151370e-38  2.662935e-04  2.790074e-04
## ASV9632     -1.643466e-38 -8.661093e-05 -8.996029e-05
## ASV4564      1.012326e-38  6.536921e-05  6.850576e-05
## ASV5289     -9.454109e-39 -6.110820e-05 -6.404770e-05
## ASV0516      8.568451e-38  5.406652e-04  5.660683e-04
## ASV1463     -3.200516e-38 -1.969057e-04 -2.059414e-04
## ASV0969      1.511912e-38  9.171002e-05  9.583997e-05
## ASV1113     -3.998190e-38 -2.517163e-04 -2.634702e-04
## ASV1234      4.394788e-40 -8.658594e-06 -9.561379e-06
## ASV3814      8.595295e-39  3.693257e-05  3.790968e-05
## ASV1000      4.186067e-38  2.588625e-04  2.707936e-04
## ASV0079     -2.429104e-39 -2.060240e-05 -2.182029e-05
## ASV0145      1.504519e-38  8.714534e-05  9.088262e-05
## ASV0457     -5.317495e-38 -3.282416e-04 -3.433220e-04
## ASV1485      1.628540e-38  1.050282e-04  1.100600e-04
## ASV0535     -1.188618e-38 -6.934424e-05 -7.229753e-05
## ASV0259     -3.416494e-38 -2.143646e-04 -2.243768e-04
## ASV0570      1.362727e-39  1.389048e-05  1.477820e-05
## ASV0906      4.485730e-38  2.764802e-04  2.891660e-04
## ASV1748     -2.368600e-38 -1.605628e-04 -1.686015e-04
## ASV5520     -1.289010e-38 -9.367005e-05 -9.862666e-05
## ASV2288     -5.252116e-38 -3.257347e-04 -3.408013e-04
## ASV1887     -7.553707e-39 -5.989482e-05 -6.323737e-05
## ASV0374     -1.691508e-38 -1.003876e-04 -1.048321e-04
## ASV0823      5.133624e-38  3.119298e-04  3.260144e-04
## ASV0717      2.460724e-38  1.552739e-04  1.626038e-04
## ASV0431      1.787548e-38  1.109934e-04  1.161084e-04
## ASV1030      6.998089e-38  4.511526e-04  4.727487e-04
## ASV1082     -1.049765e-38 -6.657221e-05 -6.971837e-05
## ASV2684      4.864533e-39  4.123904e-05  4.363475e-05
## ASV0051      6.303534e-38  3.975477e-04  4.162891e-04
## ASV0513      2.399094e-39  1.829233e-05  1.930843e-05
## ASV0581      8.083178e-38  5.120212e-04  5.361920e-04
## ASV7282      1.252159e-38  8.585091e-05  9.018453e-05
## ASV3009     -4.453000e-38 -2.805717e-04 -2.937355e-04
## ASV2106     -2.406350e-38 -1.432830e-04 -1.496167e-04
## ASV1012      1.317516e-38  8.913298e-05  9.357763e-05
## ASV0921     -1.329964e-39 -6.442460e-06 -6.628941e-06
## ASV0010     -6.226606e-38 -3.979187e-04 -4.168181e-04
## ASV1178      7.543074e-40  8.699665e-06  9.299719e-06
## ASV2848     -3.520821e-38 -2.143711e-04 -2.241027e-04
## ASV0586      9.140052e-38  5.799936e-04  6.073702e-04
## ASV4225      1.525470e-39  2.631119e-05  2.829154e-05
## ASV2156     -3.821022e-38 -2.425416e-04 -2.540083e-04
## ASV9778     -2.456204e-38 -1.531226e-04 -1.602277e-04
## ASV0493     -5.482259e-38 -3.366543e-04 -3.520406e-04
## ASV3770      1.078128e-38  5.728667e-05  5.947418e-05
## ASV0470      6.543959e-38  4.107423e-04  4.299102e-04
## ASV0262     -2.508091e-38 -1.703238e-04 -1.788622e-04
## ASV0998      3.970297e-38  2.518611e-04  2.637363e-04
## ASV7708     -1.132383e-38 -6.739976e-05 -7.037636e-05
## ASV0453     -1.537160e-39 -7.726135e-06 -8.007145e-06
## ASV0044      8.214650e-38  5.153606e-04  5.393672e-04
## ASV5490      1.344841e-38  8.223103e-05  8.599182e-05
## ASV2638      2.997621e-39  2.514719e-05  2.656068e-05
## ASV0829     -8.594898e-39 -4.676913e-05 -4.863996e-05
## ASV0601      1.439565e-38  9.338655e-05  9.787412e-05
## ASV0234      3.600485e-38  2.273823e-04  2.380823e-04
## ASV0133      4.698288e-38  2.952078e-04  3.090311e-04
## ASV0323      4.881431e-38  3.124883e-04  3.273877e-04
## ASV0854     -4.381738e-39 -2.587106e-05 -2.698975e-05
## ASV0110      6.238672e-38  3.945170e-04  4.131456e-04
## ASV0816      3.647516e-39  2.189395e-05  2.284853e-05
## ASV1031     -1.048331e-38 -6.082100e-05 -6.341924e-05
## ASV0144     -2.607409e-38 -1.633294e-04 -1.709745e-04
## ASV0020     -1.028366e-38 -7.089775e-05 -7.454296e-05
## ASV0962     -2.122252e-38 -1.331507e-04 -1.393683e-04
## ASV0794      3.963597e-38  2.604478e-04  2.731224e-04
## ASV7117     -2.141849e-38 -1.322425e-04 -1.383033e-04
## ASV1008     -1.467436e-38 -9.587786e-05 -1.005018e-04
## ASV0096      6.715224e-38  4.246097e-04  4.446105e-04
## ASV0128     -3.897035e-38 -2.535711e-04 -2.658442e-04
## ASV5232      3.027018e-38  1.976235e-04  2.071859e-04
## ASV0031      2.765044e-39  1.543284e-05  1.604881e-05
## ASV1744     -4.501257e-39 -2.645663e-05 -2.764973e-05
## ASV0289      3.767706e-38  2.375022e-04  2.486384e-04
## ASV7413     -6.380907e-39 -5.353052e-05 -5.661070e-05
## ASV0822     -4.716991e-38 -2.889269e-04 -3.020832e-04
## ASV8111     -4.169062e-38 -2.535400e-04 -2.650437e-04
## ASV0687      2.759518e-38  1.803490e-04  1.890586e-04
## ASV0112      1.120695e-38  6.626672e-05  6.920938e-05
## ASV0987      2.225322e-38  1.451913e-04  1.522111e-04
## ASV5332     -1.411156e-38 -7.633216e-05 -7.935419e-05
## ASV1129     -2.973524e-38 -1.873336e-04 -1.961139e-04
## ASV1274     -9.717767e-39 -6.088997e-05 -6.372582e-05
## ASV0119      5.478743e-38  3.461004e-04  3.623801e-04
## ASV0890      1.342358e-38  8.566794e-05  8.972576e-05
## ASV0848      7.928293e-38  5.026937e-04  5.263711e-04
## ASV5944     -4.378588e-38 -2.734946e-04 -2.862105e-04
## ASV19741    -4.182093e-38 -2.607171e-04 -2.727780e-04
## ASV0504     -4.911402e-38 -3.011804e-04 -3.149004e-04
## ASV2146     -3.209636e-38 -1.938036e-04 -2.024831e-04
## ASV0089     -2.517405e-38 -1.598594e-04 -1.674176e-04
## ASV2301     -2.729800e-38 -1.742063e-04 -1.824661e-04
## ASV2982      7.442762e-39  6.238627e-05  6.600480e-05
## ASV0891     -3.502569e-38 -2.192787e-04 -2.294979e-04
## ASV0093      5.691894e-38  3.576318e-04  3.743937e-04
## ASV0042      2.755813e-38  1.733148e-04  1.814127e-04
## ASV0980      3.856416e-38  2.382160e-04  2.491411e-04
## ASV0069     -8.801954e-39 -5.709357e-05 -5.985686e-05
## ASV1364     -6.623203e-39 -3.980354e-05 -4.156295e-05
## ASV0524     -1.027609e-38 -6.746908e-05 -7.072653e-05
## ASV0435      7.471152e-38  4.746404e-04  4.970354e-04
## ASV0517     -3.056280e-38 -1.943397e-04 -2.035149e-04
## ASV3167     -1.268383e-38 -8.461120e-05 -8.879437e-05
## ASV4280     -4.995943e-39 -2.943865e-05 -3.071142e-05
## ASV1158      1.708228e-38  1.166270e-04  1.224817e-04
## ASV2214      1.425520e-38  8.653353e-05  9.044346e-05
## ASV0544     -1.668881e-38 -1.082305e-04 -1.134390e-04
## ASV5326     -3.187033e-39 -1.973078e-05 -2.066397e-05
## ASV3765     -4.494004e-38 -2.833067e-04 -2.965693e-04
## ASV4646      6.121052e-40 -5.135886e-06 -5.754994e-06
## ASV0090      5.184869e-39  3.019867e-05  3.148705e-05
## ASV3680      4.341329e-38  2.623641e-04  2.741126e-04
## ASV0111      7.565369e-39  4.543073e-05  4.743754e-05
## ASV0768      2.548455e-38  1.637378e-04  1.715608e-04
## ASV4862     -1.739272e-39 -8.711469e-06 -9.002185e-06
## ASV1742     -3.551583e-38 -2.137701e-04 -2.233400e-04
## ASV3701     -5.809251e-39 -3.079712e-05 -3.198606e-05
## ASV2386     -2.065815e-38 -1.300212e-04 -1.361963e-04
## ASV0375     -4.939936e-38 -3.035516e-04 -3.174091e-04
## ASV2796      1.334889e-38  7.864141e-05  8.207361e-05
## ASV1369      3.408110e-38  2.086385e-04  2.181399e-04
## ASV10272    -3.040027e-38 -1.894772e-04 -1.983545e-04
## ASV10354    -3.040027e-38 -1.894772e-04 -1.983395e-04
## ASV1067     -2.322149e-39 -1.431954e-05 -1.504592e-05
## ASV1900      6.222341e-38  3.950153e-04  4.136491e-04
## ASV4079     -1.036164e-38 -6.719487e-05 -7.049164e-05
## ASV4149      4.409513e-38  2.680736e-04  2.801609e-04
## ASV5140     -3.040027e-38 -1.894772e-04 -1.983246e-04
## ASV10782    -1.804520e-39 -7.985936e-06 -8.248907e-06
## ASV4273     -7.479188e-39 -4.418140e-05 -4.616098e-05
## ASV8121      2.868455e-38  1.813753e-04  1.898674e-04
## ASV8438     -3.040027e-38 -1.894772e-04 -1.983111e-04
## ASV9390     -3.040027e-38 -1.894772e-04 -1.982962e-04
## ASV1340      4.093787e-38  2.612160e-04  2.735923e-04
## ASV2650     -4.569051e-38 -2.823142e-04 -2.952837e-04
## ASV4674      2.278712e-38  1.433735e-04  1.500595e-04
## ASV10492    -1.805289e-39 -1.050153e-05 -1.097007e-05
## ASV11430    -3.040027e-38 -1.894772e-04 -1.982740e-04
## ASV12135    -3.040027e-38 -1.894772e-04 -1.982591e-04
## ASV14970    -3.040027e-38 -1.894772e-04 -1.982443e-04
## ASV1954      3.415967e-38  2.158791e-04  2.260130e-04
## ASV2613      5.369877e-38  3.370769e-04  3.527735e-04
## ASV2757      2.209087e-38  1.345935e-04  1.406765e-04
## ASV2909     -3.113541e-38 -1.988667e-04 -2.082970e-04
## ASV2954     -6.464487e-39 -3.937425e-05 -4.116409e-05
## ASV2969      2.886375e-38  1.857963e-04  1.946734e-04
## ASV3410      5.666365e-39  3.799766e-05  3.987053e-05
## ASV3575      1.564300e-38  9.807127e-05  1.026220e-04
## ASV4275      3.536200e-38  2.175093e-04  2.274147e-04
## ASV4652      5.307887e-39  3.618649e-05  3.797620e-05
## ASV4761      3.526201e-38  2.172617e-04  2.271695e-04
## ASV6003      2.522470e-38  1.637208e-04  1.715988e-04
## ASV6110     -3.040027e-38 -1.894772e-04 -1.982756e-04
## ASV7427      1.959506e-38  1.225674e-04  1.282442e-04
## ASV8092     -3.040027e-38 -1.894772e-04 -1.982659e-04
## ASV8169     -3.040027e-38 -1.894772e-04 -1.982511e-04
## ASV9693      1.301781e-38  8.234276e-05  8.620514e-05
## ASV10913     1.384640e-38  8.926582e-05  9.355628e-05
## ASV1979     -5.120549e-39 -3.066843e-05 -3.203191e-05
## ASV3772      3.780361e-38  2.345459e-04  2.453390e-04
## ASV0113      7.657695e-39  4.707534e-05  4.922771e-05
## ASV1800     -2.968267e-39 -1.866785e-05 -1.952611e-05
## ASV2335     -4.067643e-38 -2.485557e-04 -2.598498e-04
## ASV0692      1.261345e-38  8.005816e-05  8.382869e-05
## ASV1120      1.632735e-38  1.035699e-04  1.084385e-04
## ASV1434     -8.658433e-38 -5.477939e-04 -5.735495e-04
## ASV0076     -9.294980e-39 -6.011025e-05 -6.299708e-05
## ASV0361      6.463148e-38  4.095509e-04  4.288332e-04
## ASV2231     -2.017176e-38 -1.344201e-04 -1.410900e-04
## ASV2018     -8.523333e-40 -5.744424e-06 -6.036562e-06
## ASV1529      5.329279e-38  3.414461e-04  3.577029e-04
## ASV0841     -3.123463e-39 -1.752123e-05 -1.823866e-05
## ASV2556     -3.299648e-38 -2.061075e-04 -2.156761e-04
## ASV2777      4.323659e-38  2.620276e-04  2.737712e-04
## ASV0355      3.338025e-38  2.110406e-04  2.209530e-04
## ASV5169     -4.675239e-38 -2.946640e-04 -3.084629e-04
## ASV3091      2.191844e-38  1.409302e-04  1.476619e-04
## ASV2435      3.323790e-38  2.090158e-04  2.187870e-04
## ASV6822     -2.143986e-38 -1.328274e-04 -1.389371e-04
## ASV12605    -5.095941e-38 -3.207506e-04 -3.357326e-04
## ASV0286     -3.410740e-38 -2.126288e-04 -2.224749e-04
## ASV0074     -4.693796e-40 -7.539247e-06 -8.106975e-06
## ASV2485     -2.061041e-39 -1.518901e-05 -1.601935e-05
## ASV1233     -6.447314e-38 -4.072446e-04 -4.263678e-04
## ASV0356     -3.150438e-38 -1.946276e-04 -2.035442e-04
## ASV2918     -3.966520e-38 -2.475270e-04 -2.589854e-04
## ASV1427      3.429366e-40  1.087565e-06  1.086635e-06
## ASV1409      3.677986e-38  2.355730e-04  2.467778e-04
## ASV0770      1.280859e-38  7.789181e-05  8.139730e-05
## ASV1403     -4.569919e-38 -2.867017e-04 -3.000401e-04
## ASV0314     -2.459058e-38 -1.551907e-04 -1.624581e-04
## ASV0187      1.384455e-39  4.403120e-06  4.399528e-06
## ASV0313     -3.380405e-38 -2.115447e-04 -2.213743e-04
## ASV1087      5.713278e-38  3.607247e-04  3.776270e-04
## ASV1970      3.456843e-39  2.137077e-05  2.234041e-05
## ASV0754      4.598408e-38  2.907054e-04  3.043559e-04
## ASV3775     -3.094402e-38 -1.977603e-04 -2.071488e-04
## ASV0132      1.337278e-38  8.407150e-05  8.800227e-05
## ASV2329     -7.242003e-39 -5.362889e-05 -5.650280e-05
## ASV0561      4.041917e-38  2.530664e-04  2.648287e-04
## ASV0130     -4.822305e-38 -3.062975e-04 -3.207497e-04
## ASV0226      5.486676e-38  3.460439e-04  3.622719e-04
## ASV12648    -3.957854e-38 -2.439113e-04 -2.550737e-04
## ASV0204      5.471322e-38  3.450489e-04  3.612018e-04
## ASV0767      1.032003e-38  6.235130e-05  6.513602e-05
## ASV0335     -2.971859e-38 -1.880594e-04 -1.968913e-04
## ASV5901     -9.805845e-39 -5.776868e-05 -6.028818e-05
## ASV0596     -1.273018e-38 -7.699441e-05 -8.043916e-05
## ASV9271      9.664956e-39  7.057518e-05  7.433041e-05
## ASV0904      4.785330e-38  3.051994e-04  3.196594e-04
## ASV15270    -1.158588e-38 -8.210538e-05 -8.635581e-05
## ASV0990     -1.337005e-38 -8.545439e-05 -8.951055e-05
## ASV0155     -2.928215e-38 -1.847210e-04 -1.933702e-04
## ASV0086     -3.913130e-40 -2.606845e-06 -2.735864e-06
## ASV2581     -2.542304e-39 -1.543710e-05 -1.612785e-05
## ASV1579     -3.314543e-38 -2.131325e-04 -2.233069e-04
## ASV7730      1.141014e-53 -6.986626e-06 -7.621555e-06
## ASV0897      1.389932e-38  8.971656e-05  9.401641e-05
## ASV1975      6.621688e-38  4.176498e-04  4.372145e-04
coef(best_model_1000)
## 1001 x 100 sparse Matrix of class "dgCMatrix"
##   [[ suppressing 32 column names 's0', 's1', 's2' ... ]]
##                                                                    
## (Intercept) -1.249001e-16  9.061144e-07  1.007402e-06  1.102392e-06
## ASV1236      3.133071e-38  1.929374e-04  2.021068e-04  2.113349e-04
## ASV0421     -5.547569e-38 -3.442272e-04 -3.605981e-04 -3.771811e-04
## ASV0691     -4.924975e-38 -2.980021e-04 -3.121670e-04 -3.261323e-04
## ASV0899     -1.324028e-39 -2.647790e-06 -2.765069e-06 -2.604029e-06
## ASV1004      6.299724e-38  3.897104e-04  4.082281e-04  4.269417e-04
## ASV1041     -4.258951e-38 -2.647980e-04 -2.773742e-04 -2.901610e-04
## ASV1058      5.855981e-38  3.627131e-04  3.799159e-04  3.973558e-04
## ASV12542     1.842670e-38  1.121451e-04  1.174787e-04  1.227656e-04
## ASV1294      6.764978e-38  4.216432e-04  4.416631e-04  4.620777e-04
## ASV13113     2.351661e-38  1.510659e-04  1.582506e-04  1.657996e-04
## ASV1318      5.929751e-38  3.679276e-04  3.853912e-04  4.031231e-04
## ASV2269     -1.761531e-38 -1.098640e-04 -1.150604e-04 -1.203890e-04
## ASV2542      3.703376e-38  2.354226e-04  2.465969e-04  2.582379e-04
## ASV2660     -3.447239e-38 -2.126964e-04 -2.227598e-04 -2.329496e-04
## ASV2737     -1.456066e-39 -1.119154e-05 -1.168387e-05 -1.233890e-05
## ASV2840      4.606802e-38  2.831073e-04  2.965189e-04  3.100115e-04
## ASV3053      2.609821e-39  1.535022e-05  1.608569e-05  1.677573e-05
## ASV3077      1.430712e-38  8.806575e-05  9.223487e-05  9.643530e-05
## ASV3134      4.753922e-38  3.039576e-04  3.184156e-04  3.335322e-04
## ASV3140      2.100119e-38  1.338543e-04  1.401908e-04  1.468280e-04
## ASV3579      7.918462e-39  5.276151e-05  5.530391e-05  5.803307e-05
## ASV6119     -1.761531e-38 -1.098637e-04 -1.150433e-04 -1.203703e-04
## ASV7557     -1.761531e-38 -1.098637e-04 -1.150345e-04 -1.203609e-04
## ASV8422      1.007031e-38  5.994817e-05  6.284206e-05  6.559821e-05
## ASV1086     -5.080525e-39 -3.066641e-05 -3.212233e-05 -3.354974e-05
## ASV1310      3.341700e-38  2.077064e-04  2.175725e-04  2.275961e-04
## ASV15750    -8.427200e-39 -5.221488e-05 -5.464778e-05 -5.716218e-05
## ASV16905    -1.761531e-38 -1.098635e-04 -1.150313e-04 -1.203570e-04
## ASV2033      3.219968e-38  2.041570e-04  2.138967e-04  2.239607e-04
## ASV2089      1.201683e-38  7.523457e-05  7.877109e-05  8.243487e-05
## ASV2127      4.826544e-38  2.987645e-04  3.129340e-04  3.272934e-04
## ASV2725      5.527505e-38  3.390615e-04  3.551648e-04  3.712955e-04
## ASV2804     -1.761531e-38 -1.098634e-04 -1.150291e-04 -1.203544e-04
## ASV3075      3.447315e-38  2.140655e-04  2.242392e-04  2.345637e-04
## ASV3327      3.161305e-38  2.003626e-04  2.099258e-04  2.198006e-04
## ASV3342      3.467863e-38  2.187734e-04  2.291435e-04  2.398750e-04
## ASV3532     -3.132836e-38 -1.979555e-04 -2.073123e-04 -2.170394e-04
## ASV3600      3.984828e-38  2.496622e-04  2.615488e-04  2.737040e-04
## ASV4013      3.390601e-38  2.106453e-04  2.206513e-04  2.308124e-04
## ASV4136      3.397772e-38  2.089718e-04  2.188498e-04  2.288255e-04
## ASV4195      1.761531e-38  1.098632e-04  1.150165e-04  1.203406e-04
## ASV4407     -1.761531e-38 -1.098632e-04 -1.150078e-04 -1.203312e-04
## ASV4717      1.290371e-39  5.281759e-06  5.597077e-06  5.711347e-06
## ASV6794      1.867634e-38  1.118327e-04  1.171811e-04  1.223614e-04
## ASV8324     -1.761531e-38 -1.098631e-04 -1.150058e-04 -1.203282e-04
## ASV8981     -5.080524e-39 -3.032750e-05 -3.168601e-05 -3.308348e-05
## ASV9859      1.271657e-38  8.332313e-05  8.734256e-05  9.159144e-05
## ASV0936     -2.763764e-38 -1.721959e-04 -1.803995e-04 -1.887307e-04
## ASV12683    -2.597726e-39 -1.757830e-05 -1.836433e-05 -1.928790e-05
## ASV1293      4.103429e-38  2.534863e-04  2.654675e-04  2.776239e-04
## ASV13055    -4.412996e-39 -2.704357e-05 -2.824588e-05 -2.952930e-05
## ASV17063    -1.761531e-38 -1.098629e-04 -1.149906e-04 -1.203117e-04
## ASV2228      1.761531e-38  1.098629e-04  1.149819e-04  1.203023e-04
## ASV2769     -3.595451e-39 -2.139338e-05 -2.232012e-05 -2.330103e-05
## ASV2803      8.703816e-39  5.137887e-05  5.387847e-05  5.621939e-05
## ASV2896      2.186891e-38  1.369429e-04  1.434953e-04  1.501629e-04
## ASV3062      6.184777e-39  4.103651e-05  4.306309e-05  4.518064e-05
## ASV3107      2.630824e-38  1.655615e-04  1.734509e-04  1.815493e-04
## ASV3265      5.341940e-38  3.301578e-04  3.457688e-04  3.616042e-04
## ASV3666     -1.114465e-39 -7.401172e-06 -7.682167e-06 -8.063664e-06
## ASV4497      1.264747e-38  7.828967e-05  8.205491e-05  8.581705e-05
## ASV6914     -6.022177e-39 -3.861465e-05 -4.038316e-05 -4.230824e-05
## ASV0576     -6.389199e-38 -3.888766e-04 -4.072977e-04 -4.256414e-04
## ASV0673      1.553071e-38  1.017386e-04  1.065713e-04  1.117493e-04
## ASV0772      1.888544e-38  1.171483e-04  1.227380e-04  1.283811e-04
## ASV0862     -1.577283e-38 -9.586874e-05 -1.003910e-04 -1.049002e-04
## ASV0898      1.494744e-38  9.664872e-05  1.012547e-04  1.061179e-04
## ASV0910      3.275872e-38  2.096304e-04  2.196011e-04  2.300340e-04
## ASV0964     -2.301490e-38 -1.418109e-04 -1.485153e-04 -1.552906e-04
## ASV10059     1.525478e-38  9.836539e-05  1.030853e-04  1.080214e-04
## ASV10263    -1.761531e-38 -1.098626e-04 -1.150302e-04 -1.203527e-04
## ASV1088      1.737606e-38  1.109894e-04  1.162792e-04  1.217990e-04
## ASV1101      3.039775e-38  1.900106e-04  1.990098e-04  2.082316e-04
## ASV1183      1.927595e-38  1.218231e-04  1.275634e-04  1.335492e-04
## ASV11956     8.034700e-39  4.655131e-05  4.879179e-05  5.086582e-05
## ASV12774    -2.459980e-39 -1.668451e-05 -1.744149e-05 -1.831993e-05
## ASV1321      7.011807e-39  4.749508e-05  4.980056e-05  5.229685e-05
## ASV13793    -1.761531e-38 -1.098625e-04 -1.150202e-04 -1.203414e-04
## ASV14482    -1.373377e-39 -1.039061e-05 -1.085186e-05 -1.144867e-05
## ASV15483     1.217911e-38  7.672963e-05  8.042605e-05  8.418622e-05
## ASV2062      7.731123e-38  4.831722e-04  5.060198e-04  5.294748e-04
## ASV2132      3.470506e-38  2.197137e-04  2.301998e-04  2.410181e-04
## ASV2413      5.051081e-38  3.122968e-04  3.270594e-04  3.420448e-04
## ASV2490      3.356463e-38  2.049034e-04  2.145658e-04  2.242610e-04
## ASV2594      1.808116e-38  1.123206e-04  1.176550e-04  1.230759e-04
## ASV2822     -1.761531e-38 -1.098625e-04 -1.150346e-04 -1.203566e-04
## ASV2863      3.096232e-38  1.909330e-04  1.999101e-04  2.090463e-04
## ASV2910      4.045912e-38  2.486821e-04  2.604969e-04  2.723554e-04
## ASV2980      1.459677e-38  9.067086e-05  9.492413e-05  9.929625e-05
## ASV3307      1.761531e-38  1.098624e-04  1.150202e-04  1.203407e-04
## ASV3474      2.664464e-38  1.703347e-04  1.784590e-04  1.869292e-04
## ASV3502      5.699692e-38  3.568423e-04  3.737714e-04  3.911301e-04
## ASV4236      2.952451e-38  1.819339e-04  1.904635e-04  1.991538e-04
## ASV4842     -9.516024e-39 -6.037248e-05 -6.321923e-05 -6.619667e-05
## ASV4894     -1.761531e-38 -1.098624e-04 -1.150301e-04 -1.203513e-04
## ASV5290      2.150314e-38  1.340244e-04  1.404209e-04  1.469127e-04
## ASV5501      4.076922e-39  2.517346e-05  2.636410e-05  2.756866e-05
## ASV5795      1.425114e-38  8.996845e-05  9.425847e-05  9.867372e-05
## ASV5987     -1.761531e-38 -1.098623e-04 -1.150333e-04 -1.203548e-04
## ASV6267     -1.761531e-38 -1.098623e-04 -1.150246e-04 -1.203453e-04
## ASV6862      3.472093e-38  2.109825e-04  2.209503e-04  2.308842e-04
## ASV7145      6.514140e-39  3.793720e-05  3.972365e-05  4.142321e-05
## ASV7673     -1.761531e-38 -1.098623e-04 -1.150224e-04 -1.203425e-04
## ASV7789      5.781709e-39  3.884250e-05  4.074396e-05  4.277265e-05
## ASV7809     -2.504185e-39 -1.453640e-05 -1.516652e-05 -1.581169e-05
## ASV8002     -1.761531e-38 -1.098622e-04 -1.150154e-04 -1.203351e-04
## ASV8205      1.018531e-38  6.266018e-05  6.568863e-05  6.868490e-05
## ASV9155     -1.330777e-38 -8.282886e-05 -8.669474e-05 -9.069533e-05
## ASV9221     -2.388223e-39 -1.445874e-05 -1.507178e-05 -1.574644e-05
## ASV9311     -1.761531e-38 -1.098622e-04 -1.150035e-04 -1.203219e-04
## ASV9557     -1.761531e-38 -1.098622e-04 -1.149948e-04 -1.203125e-04
## ASV9936     -1.761531e-38 -1.098622e-04 -1.149861e-04 -1.203030e-04
## ASV1445      3.997197e-38  2.521075e-04  2.641126e-04  2.764744e-04
## ASV4232      3.338541e-38  2.118500e-04  2.219670e-04  2.324271e-04
## ASV6479     -8.157800e-40 -1.222256e-06 -1.209065e-06 -1.061901e-06
## ASV0142     -9.010265e-38 -5.539763e-04 -5.801383e-04 -6.065581e-04
## ASV0378     -2.984397e-38 -1.833058e-04 -1.919293e-04 -2.006546e-04
## ASV1122      5.277825e-38  3.329563e-04  3.487725e-04  3.651012e-04
## ASV0123     -8.831622e-38 -5.428028e-04 -5.683888e-04 -5.942627e-04
## ASV2064      9.456684e-39  5.509733e-05  5.765783e-05  6.013226e-05
## ASV4459     -9.719539e-39 -6.089954e-05 -6.375611e-05 -6.671956e-05
## ASV0448      1.423142e-38  9.453121e-05  9.909573e-05  1.039810e-04
## ASV0397      3.967868e-38  2.498767e-04  2.617620e-04  2.739956e-04
## ASV0485      5.602948e-38  3.488520e-04  3.653669e-04  3.822388e-04
## ASV1566      4.654943e-38  2.920020e-04  3.058371e-04  3.200688e-04
## ASV1365      3.010399e-38  1.883007e-04  1.972552e-04  2.064076e-04
## ASV1065      6.170416e-38  3.879903e-04  4.063513e-04  4.253106e-04
## ASV0722     -1.470608e-39 -8.356450e-06 -8.764456e-06 -9.129294e-06
## ASV12660    -2.979446e-38 -1.829083e-04 -1.915260e-04 -2.002329e-04
## ASV0223     -1.235827e-39 -7.079307e-06 -7.420103e-06 -7.729747e-06
## ASV0229      2.730513e-38  1.733024e-04  1.815336e-04  1.900878e-04
## ASV0877     -1.108271e-38 -6.934177e-05 -7.251258e-05 -7.586708e-05
## ASV0983      5.740917e-38  3.565161e-04  3.733500e-04  3.905372e-04
## ASV0626     -1.988713e-38 -1.177673e-04 -1.231792e-04 -1.285500e-04
## ASV4146     -3.218327e-39 -2.045870e-05 -2.133370e-05 -2.233899e-05
## ASV4175     -3.481381e-38 -2.179938e-04 -2.282376e-04 -2.388371e-04
## ASV2082     -2.075558e-39 -1.466889e-05 -1.550171e-05 -1.631361e-05
## ASV2272      2.490583e-38  1.563717e-04  1.638329e-04  1.714675e-04
## ASV2245     -3.017452e-38 -1.899536e-04 -1.988646e-04 -2.081519e-04
## ASV0590     -1.761143e-38 -1.141166e-04 -1.196345e-04 -1.253940e-04
## ASV0217     -3.047970e-38 -1.783840e-04 -1.866705e-04 -1.946967e-04
## ASV0416      2.949399e-38  1.783479e-04  1.866963e-04  1.950398e-04
## ASV1056      3.274151e-38  2.102085e-04  2.203026e-04  2.308062e-04
## ASV7777     -3.002033e-38 -1.896093e-04 -1.984965e-04 -2.077997e-04
## ASV0455      5.747357e-39  3.770093e-05  3.941339e-05  4.132813e-05
## ASV0604      5.799389e-39  4.114016e-05  4.321611e-05  4.547374e-05
## ASV6100     -2.766616e-38 -1.749477e-04 -1.831401e-04 -1.917330e-04
## ASV11359    -3.118370e-38 -1.944198e-04 -2.035125e-04 -2.129179e-04
## ASV6604      2.173846e-38  1.380434e-04  1.446705e-04  1.514933e-04
## ASV5004     -1.832224e-38 -1.148694e-04 -1.201867e-04 -1.257726e-04
## ASV1483     -1.683076e-38 -1.064335e-04 -1.113709e-04 -1.165951e-04
## ASV9773     -3.550227e-38 -2.238822e-04 -2.343609e-04 -2.453245e-04
## ASV4059      2.938087e-39  2.043102e-05  2.148306e-05  2.258904e-05
## ASV1193      5.793652e-38  3.635663e-04  3.808316e-04  3.985639e-04
## ASV4610     -6.006542e-39 -3.289866e-05 -3.435845e-05 -3.570905e-05
## ASV0742     -2.298570e-38 -1.371863e-04 -1.434842e-04 -1.497981e-04
## ASV1502      8.007334e-41 -2.002875e-06 -2.039349e-06 -2.261019e-06
## ASV0195     -5.832160e-39 -3.973575e-05 -4.167975e-05 -4.378230e-05
## ASV1213      1.900259e-38  1.158907e-04  1.211927e-04  1.266571e-04
## ASV1648     -2.634404e-38 -1.658958e-04 -1.736336e-04 -1.817452e-04
## ASV6984     -1.961126e-38 -1.238836e-04 -1.296297e-04 -1.357025e-04
## ASV0396     -1.668481e-38 -9.270906e-05 -9.704518e-05 -1.009559e-04
## ASV4297      3.047471e-38  1.867070e-04  1.955709e-04  2.044475e-04
## ASV2622      6.888392e-38  4.255820e-04  4.456766e-04  4.660828e-04
## ASV3512      9.672295e-39  6.361441e-05  6.675543e-05  7.001943e-05
## ASV2411      2.270339e-38  1.449659e-04  1.518106e-04  1.590046e-04
## ASV2291     -5.441058e-39 -3.626678e-05 -3.814461e-05 -4.003719e-05
## ASV0807      2.604318e-38  1.707534e-04  1.789188e-04  1.876199e-04
## ASV1292      1.555548e-38  9.671461e-05  1.011968e-04  1.058580e-04
## ASV1035      7.560947e-39  4.445424e-05  4.650978e-05  4.851931e-05
## ASV0070     -1.712350e-38 -1.021739e-04 -1.069515e-04 -1.116572e-04
## ASV0255      6.544534e-39  4.032696e-05  4.218059e-05  4.410109e-05
## ASV0057     -7.196267e-38 -4.395095e-04 -4.601513e-04 -4.809502e-04
## ASV0077     -1.116893e-38 -6.528255e-05 -6.830784e-05 -7.124004e-05
## ASV0625      7.103019e-38  4.374509e-04  4.579578e-04  4.788449e-04
## ASV2464      3.477612e-38  2.120437e-04  2.219744e-04  2.319858e-04
## ASV1315      5.946957e-38  3.736696e-04  3.914768e-04  4.097468e-04
## ASV2673      4.308417e-38  2.756272e-04  2.887948e-04  3.025174e-04
## ASV2161      1.768595e-38  1.138762e-04  1.193504e-04  1.250599e-04
## ASV0337     -2.931708e-38 -1.832138e-04 -1.919311e-04 -2.008293e-04
## ASV7680     -3.404884e-38 -2.150480e-04 -2.251340e-04 -2.356829e-04
## ASV0611      7.352171e-38  4.662827e-04  4.884546e-04  5.114518e-04
## ASV3118     -2.500910e-38 -1.589829e-04 -1.664547e-04 -1.743067e-04
## ASV1284      2.644200e-38  1.723854e-04  1.803981e-04  1.890966e-04
## ASV0889      2.055484e-38  1.272737e-04  1.333347e-04  1.394582e-04
## ASV4649     -2.121874e-38 -1.338288e-04 -1.400721e-04 -1.466246e-04
## ASV1108     -2.641951e-38 -1.701648e-04 -1.782052e-04 -1.867267e-04
## ASV0738     -5.908183e-39 -2.655865e-05 -2.771101e-05 -2.846011e-05
## ASV0473      4.155210e-39  2.524468e-05  2.639642e-05  2.758023e-05
## ASV0598     -3.187637e-38 -1.933020e-04 -2.023816e-04 -2.114578e-04
## ASV0429      4.956004e-38  3.099324e-04  3.245709e-04  3.396217e-04
## ASV1549      4.785423e-38  3.070379e-04  3.216705e-04  3.369986e-04
## ASV1203      3.731441e-38  2.319491e-04  2.428369e-04  2.540260e-04
## ASV4532      1.922455e-39  9.565675e-06  1.005106e-05  1.039539e-05
## ASV0274     -3.852814e-38 -2.334527e-04 -2.444666e-04 -2.554323e-04
## ASV0163     -5.515623e-38 -3.359041e-04 -3.515550e-04 -3.673932e-04
## ASV1298      2.242946e-38  1.362926e-04  1.426131e-04  1.490209e-04
## ASV9424     -4.497007e-38 -2.851788e-04 -2.985903e-04 -3.126417e-04
## ASV0412      7.043598e-38  4.384212e-04  4.591469e-04  4.803370e-04
## ASV0284      3.217293e-38  1.964214e-04  2.056085e-04  2.148967e-04
## ASV0620     -2.264305e-38 -1.472501e-04 -1.541953e-04 -1.616362e-04
## ASV0153     -4.777492e-38 -3.040996e-04 -3.186625e-04 -3.337271e-04
## ASV0498      3.908578e-39  3.282664e-05  3.442643e-05  3.644424e-05
## ASV0097      3.406348e-38  2.160606e-04  2.263002e-04  2.369616e-04
## ASV0104     -1.612636e-37 -1.007436e-03 -1.055223e-03 -1.104135e-03
## ASV1282      2.775381e-38  1.784123e-04  1.868989e-04  1.958000e-04
## ASV3883     -1.582262e-38 -1.016338e-04 -1.064176e-04 -1.114880e-04
## ASV0801      1.543506e-38  1.019392e-04  1.066975e-04  1.119217e-04
## ASV1611     -6.138811e-38 -3.875729e-04 -4.058371e-04 -4.248490e-04
## ASV0227     -2.145864e-38 -1.390629e-04 -1.457545e-04 -1.527710e-04
## ASV0833      2.307460e-38  1.503799e-04  1.575809e-04  1.652058e-04
## ASV0718      5.752412e-38  3.611968e-04  3.782723e-04  3.958932e-04
## ASV1139      2.218115e-38  1.335708e-04  1.397017e-04  1.459081e-04
## ASV0766     -1.602961e-38 -9.976165e-05 -1.043875e-04 -1.092022e-04
## ASV2091      7.916680e-38  4.835075e-04  5.062491e-04  5.291481e-04
## ASV1238     -5.836449e-39 -2.502779e-05 -2.610076e-05 -2.675100e-05
## ASV9193     -6.133051e-39 -5.058872e-05 -5.290561e-05 -5.594620e-05
## ASV0290     -5.878822e-39 -3.840336e-05 -4.022656e-05 -4.217449e-05
## ASV0231      6.145335e-38  3.835428e-04  4.015906e-04  4.201756e-04
## ASV0185      8.140561e-39  6.719574e-05  7.056025e-05  7.466832e-05
## ASV2330      1.801334e-38  1.112742e-04  1.165388e-04  1.218744e-04
## ASV3119     -1.890145e-38 -1.254106e-04 -1.314064e-04 -1.378723e-04
## ASV2368     -2.727240e-38 -1.747661e-04 -1.829704e-04 -1.916737e-04
## ASV0122     -2.266189e-38 -1.381388e-04 -1.447139e-04 -1.512504e-04
## ASV1044      3.693122e-38  2.396754e-04  2.511340e-04  2.632359e-04
## ASV0160     -5.622767e-38 -3.408501e-04 -3.567857e-04 -3.727866e-04
## ASV0326      3.500982e-38  2.200764e-04  2.306143e-04  2.413762e-04
## ASV1388      6.164818e-38  3.855239e-04  4.037625e-04  4.224939e-04
## ASV0792      7.055394e-38  4.384047e-04  4.589801e-04  4.801179e-04
## ASV0036     -4.341619e-38 -2.754152e-04 -2.885896e-04 -3.021843e-04
## ASV2125      7.212501e-38  4.504528e-04  4.717706e-04  4.936263e-04
## ASV1075      1.338293e-38  8.600306e-05  9.014910e-05  9.445586e-05
## ASV0390      1.253755e-38  8.409540e-05  8.810937e-05  9.249255e-05
## ASV3790     -5.735622e-38 -3.606185e-04 -3.776142e-04 -3.952322e-04
## ASV1535     -4.340024e-39 -3.242912e-05 -3.396801e-05 -3.580560e-05
## ASV0263      1.187358e-38  7.485188e-05  7.833070e-05  8.199039e-05
## ASV0675      9.307161e-38  5.953687e-04  6.235977e-04  6.532029e-04
## ASV3348      8.656278e-39  5.709178e-05  5.991906e-05  6.285879e-05
## ASV0058     -9.122278e-38 -5.658057e-04 -5.925354e-04 -6.197924e-04
## ASV4142      2.292079e-38  1.432785e-04  1.499694e-04  1.569239e-04
## ASV0059     -7.879787e-38 -4.875709e-04 -5.105542e-04 -5.339791e-04
## ASV0013     -1.637259e-37 -1.023254e-03 -1.071668e-03 -1.121361e-03
## ASV0033     -4.719255e-38 -3.000726e-04 -3.143829e-04 -3.292271e-04
## ASV4354     -2.135964e-38 -1.323821e-04 -1.385868e-04 -1.449520e-04
## ASV0022     -4.986826e-38 -3.170200e-04 -3.321039e-04 -3.477797e-04
## ASV0134     -1.193838e-38 -7.855181e-05 -8.232229e-05 -8.634548e-05
## ASV0415     -1.175890e-38 -6.533810e-05 -6.832665e-05 -7.108175e-05
## ASV10103    -3.511087e-38 -2.210616e-04 -2.314332e-04 -2.422402e-04
## ASV1613      5.799264e-38  3.600171e-04  3.769616e-04  3.943092e-04
## ASV0135     -4.478038e-39 -2.161185e-05 -2.249002e-05 -2.319646e-05
## ASV0469     -7.254312e-38 -4.495635e-04 -4.706218e-04 -4.922397e-04
## ASV0471      4.519901e-38  2.906884e-04  3.043881e-04  3.189025e-04
## ASV0451     -1.173322e-38 -7.677866e-05 -8.051276e-05 -8.442917e-05
## ASV0747      1.684687e-38  1.115359e-04  1.168645e-04  1.225962e-04
## ASV1314     -2.604417e-38 -1.685311e-04 -1.765204e-04 -1.850013e-04
## ASV0425     -8.316441e-38 -5.092673e-04 -5.331341e-04 -5.573177e-04
## ASV0559     -4.740023e-38 -2.907009e-04 -3.043054e-04 -3.181316e-04
## ASV0148     -5.151179e-38 -3.133214e-04 -3.279894e-04 -3.427559e-04
## ASV0129     -2.643876e-38 -1.546995e-04 -1.618648e-04 -1.688397e-04
## ASV1072      2.514587e-38  1.498860e-04  1.568862e-04  1.637994e-04
## ASV2390      1.792174e-38  1.102213e-04  1.154024e-04  1.206592e-04
## ASV0548      5.195657e-38  3.267256e-04  3.422448e-04  3.582239e-04
## ASV0168     -7.970435e-38 -4.932037e-04 -5.163699e-04 -5.400635e-04
## ASV0066     -5.880654e-38 -3.680560e-04 -3.854432e-04 -4.033395e-04
## ASV0468     -2.156339e-38 -1.350361e-04 -1.413525e-04 -1.479151e-04
## ASV0172     -1.376210e-38 -7.686478e-05 -8.032894e-05 -8.359185e-05
## ASV0236     -3.246804e-38 -1.897687e-04 -1.984600e-04 -2.069944e-04
## ASV0250     -7.781599e-40  1.006734e-05  1.080241e-05  1.206013e-05
## ASV0338     -5.609719e-39 -2.574152e-05 -2.678285e-05 -2.755198e-05
## ASV0450     -2.980329e-40 -2.321319e-06 -2.432247e-06 -2.571066e-06
## ASV0377      6.423902e-38  4.027969e-04  4.217977e-04  4.414155e-04
## ASV1022      1.776651e-38  1.123110e-04  1.175648e-04  1.230786e-04
## ASV6174     -4.557312e-39 -2.773595e-05 -2.902771e-05 -3.033325e-05
## ASV0786      7.561788e-39  4.524627e-05  4.733565e-05  4.942272e-05
## ASV0053     -7.710100e-38 -4.860181e-04 -5.089965e-04 -5.328052e-04
## ASV0697     -2.322761e-38 -1.414194e-04 -1.479960e-04 -1.546670e-04
## ASV0785      5.747145e-38  3.583756e-04  3.753128e-04  3.926874e-04
## ASV1967     -3.902972e-38 -2.391834e-04 -2.504475e-04 -2.618095e-04
## ASV0385     -1.854378e-38 -1.096718e-04 -1.147699e-04 -1.197880e-04
## ASV0295     -1.077806e-39 -6.680155e-07 -5.653973e-07 -2.752143e-07
## ASV0072     -6.300848e-38 -3.860527e-04 -4.040912e-04 -4.224368e-04
## ASV0157     -2.674913e-38 -1.616090e-04 -1.691075e-04 -1.766534e-04
## ASV0501      2.719653e-38  1.783235e-04  1.868629e-04  1.959280e-04
## ASV10729    -4.667636e-38 -2.955790e-04 -3.095157e-04 -3.240592e-04
## ASV1470      2.276183e-38  1.323368e-04  1.385252e-04  1.444554e-04
## ASV0050     -1.552864e-37 -9.656828e-04 -1.011108e-03 -1.057743e-03
## ASV0411     -4.571970e-39 -2.486094e-05 -2.595708e-05 -2.698236e-05
## ASV0549      2.846724e-38  1.815512e-04  1.902556e-04  1.992785e-04
## ASV0184      1.803143e-38  1.133680e-04  1.186896e-04  1.242253e-04
## ASV0705      2.127130e-38  1.369715e-04  1.434864e-04  1.503405e-04
## ASV1715      5.451392e-38  3.426063e-04  3.587628e-04  3.754935e-04
## ASV0603      6.303247e-39  4.100900e-05  4.291892e-05  4.499219e-05
## ASV0826      1.883618e-38  1.140217e-04  1.193548e-04  1.246976e-04
## ASV0034     -7.066366e-38 -4.374977e-04 -4.579500e-04 -4.789610e-04
## ASV0838      1.483163e-38  9.444823e-05  9.883824e-05  1.034999e-04
## ASV0614     -4.004712e-38 -2.492571e-04 -2.609964e-04 -2.730391e-04
## ASV0014     -1.504048e-37 -9.372845e-04 -9.813157e-04 -1.026675e-03
## ASV0585     -9.271648e-39 -5.561584e-05 -5.826175e-05 -6.085121e-05
## ASV0016     -1.536910e-37 -9.582096e-04 -1.003158e-03 -1.049548e-03
## ASV5394     -3.851025e-38 -2.431785e-04 -2.546600e-04 -2.665911e-04
## ASV0666      3.316568e-38  2.065365e-04  2.162012e-04  2.261822e-04
## ASV2085      1.443304e-38  8.251678e-05  8.620213e-05  8.980156e-05
## ASV0003     -1.408628e-37 -8.767033e-04 -9.177257e-04 -9.600849e-04
## ASV0346     -4.125123e-39 -1.721872e-05 -1.778535e-05 -1.816951e-05
## ASV0267     -2.302057e-38 -1.416055e-04 -1.480550e-04 -1.547902e-04
## ASV0353      2.834266e-38  1.910644e-04  2.002709e-04  2.102523e-04
## ASV2419      3.995432e-38  2.473374e-04  2.589040e-04  2.707832e-04
## ASV0447      1.710637e-38  1.153985e-04  1.210613e-04  1.271122e-04
## ASV0654      6.042853e-38  3.826604e-04  4.008056e-04  4.196405e-04
## ASV0151      8.512835e-39  5.792987e-05  6.087313e-05  6.394633e-05
## ASV0065     -5.669201e-38 -3.511706e-04 -3.676712e-04 -3.845615e-04
## ASV0527      4.097663e-38  2.565767e-04  2.686172e-04  2.810932e-04
## ASV4055     -1.480477e-38 -9.645305e-05 -1.010584e-04 -1.059479e-04
## ASV0166     -4.804275e-38 -2.890922e-04 -3.025436e-04 -3.160124e-04
## ASV0417     -4.017932e-38 -2.491413e-04 -2.607931e-04 -2.727801e-04
## ASV0078     -3.257390e-38 -1.977389e-04 -2.069215e-04 -2.162187e-04
## ASV0322     -3.965370e-38 -2.380086e-04 -2.490554e-04 -2.601142e-04
## ASV0156     -5.105976e-38 -3.099732e-04 -3.244523e-04 -3.390429e-04
## ASV0648     -4.488601e-38 -2.853578e-04 -2.988298e-04 -3.129292e-04
## ASV0407      3.103441e-39  1.917429e-05  2.013282e-05  2.106982e-05
## ASV2030     -1.031307e-38 -6.165203e-05 -6.455263e-05 -6.740165e-05
## ASV0300      2.546967e-38  1.691349e-04  1.773020e-04  1.860213e-04
## ASV1150     -3.852651e-39 -2.250545e-05 -2.347579e-05 -2.447856e-05
## ASV0958      2.664002e-38  1.727893e-04  1.810726e-04  1.897960e-04
## ASV0216     -4.906846e-38 -3.015358e-04 -3.155102e-04 -3.298705e-04
## ASV0446      6.489840e-38  4.186228e-04  4.385280e-04  4.595174e-04
## ASV0367     -2.295717e-38 -1.438275e-04 -1.505690e-04 -1.575680e-04
## ASV0200     -4.250453e-38 -2.643891e-04 -2.768377e-04 -2.896170e-04
## ASV0334     -2.377183e-38 -1.387640e-04 -1.449634e-04 -1.511730e-04
## ASV1311      3.031849e-38  1.896086e-04  1.984447e-04  2.076450e-04
## ASV0458      3.264472e-38  2.027056e-04  2.122837e-04  2.220540e-04
## ASV1371      9.212320e-40  6.054493e-06  6.356439e-06  6.667640e-06
## ASV0418      3.956423e-38  2.411444e-04  2.524588e-04  2.638573e-04
## ASV0004      4.709975e-38  2.926777e-04  3.064609e-04  3.205825e-04
## ASV1943      3.491045e-38  2.148851e-04  2.250621e-04  2.353288e-04
## ASV1495     -7.505106e-39 -5.442197e-05 -5.715922e-05 -6.019924e-05
## ASV0901     -5.270082e-38 -3.350038e-04 -3.509117e-04 -3.674758e-04
## ASV0628      3.182044e-38  1.969984e-04  2.061649e-04  2.156191e-04
## ASV0400      1.272268e-38  8.065696e-05  8.440975e-05  8.837008e-05
## ASV0116     -4.015755e-38 -2.542553e-04 -2.663371e-04 -2.788606e-04
## ASV0788      3.388298e-38  2.125580e-04  2.225871e-04  2.329455e-04
## ASV0117      2.104939e-38  1.357842e-04  1.423066e-04  1.491253e-04
## ASV3137      6.088051e-39  3.848299e-05  4.029869e-05  4.219119e-05
## ASV0001      5.769339e-38  3.536812e-04  3.701227e-04  3.869308e-04
## ASV1651      3.849282e-38  2.335887e-04  2.444161e-04  2.553928e-04
## ASV1692      3.916604e-38  2.504420e-04  2.623838e-04  2.748405e-04
## ASV0660      2.398237e-38  1.458939e-04  1.525745e-04  1.594238e-04
## ASV0508      3.230712e-39  1.738897e-05  1.818771e-05  1.888983e-05
## ASV1660     -1.583265e-38 -1.029841e-04 -1.079352e-04 -1.131455e-04
## ASV0233      8.806217e-39  5.556732e-05  5.825810e-05  6.099114e-05
## ASV1343     -4.010104e-38 -2.536869e-04 -2.656777e-04 -2.781514e-04
## ASV0209      3.847575e-38  2.369220e-04  2.479013e-04  2.592065e-04
## ASV0193     -4.956363e-38 -2.989608e-04 -3.128243e-04 -3.267906e-04
## ASV0357     -3.708285e-39 -2.040575e-05 -2.122741e-05 -2.206284e-05
## ASV0198      1.029473e-38  6.738208e-05  7.056704e-05  7.398561e-05
## ASV0007      5.469502e-38  3.352941e-04  3.508548e-04  3.667872e-04
## ASV1772     -5.550091e-39 -3.369084e-05 -3.525756e-05 -3.683845e-05
## ASV0009      5.167512e-38  3.163593e-04  3.310047e-04  3.460131e-04
## ASV0006      2.157679e-38  1.287100e-04  1.345301e-04  1.404549e-04
## ASV0011     -5.581552e-38 -3.539176e-04 -3.706337e-04 -3.880747e-04
## ASV0015      3.953436e-38  2.458156e-04  2.573752e-04  2.692408e-04
## ASV0017      4.193162e-38  2.603749e-04  2.725782e-04  2.851269e-04
## ASV0235     -3.262141e-38 -2.080464e-04 -2.178794e-04 -2.281858e-04
## ASV0382      4.625552e-39  3.761896e-05  3.963913e-05  4.191380e-05
## ASV2357      4.986866e-38  3.147353e-04  3.295625e-04  3.449980e-04
## ASV0567     -3.682815e-38 -2.273657e-04 -2.379658e-04 -2.488596e-04
## ASV0165      3.988685e-38  2.524107e-04  2.643067e-04  2.767145e-04
## ASV0005      8.107507e-38  5.030376e-04  5.265366e-04  5.507584e-04
## ASV0384     -4.532717e-39 -2.391229e-05 -2.488721e-05 -2.580577e-05
## ASV0002      1.659396e-38  1.056060e-04  1.106816e-04  1.159125e-04
## ASV3017      4.757079e-38  2.941134e-04  3.077482e-04  3.218508e-04
## ASV0091      1.764900e-38  1.126809e-04  1.180262e-04  1.236203e-04
## ASV0186     -4.797272e-38 -3.025173e-04 -3.167599e-04 -3.315807e-04
## ASV0370      4.710406e-39  3.242822e-05  3.393046e-05  3.565874e-05
## ASV0018      8.430121e-38  5.238270e-04  5.482902e-04  5.735522e-04
## ASV1377      7.378245e-38  4.584754e-04  4.798647e-04  5.019620e-04
## ASV0019      8.439473e-38  5.246096e-04  5.490704e-04  5.743771e-04
## ASV0023      7.066716e-39  3.811689e-05  3.961536e-05  4.114196e-05
## ASV2194      2.682544e-38  1.657151e-04  1.735858e-04  1.815483e-04
## ASV1155     -3.632665e-39 -2.045096e-05 -2.112931e-05 -2.198957e-05
## ASV0510     -3.222010e-38 -1.914614e-04 -2.000538e-04 -2.088309e-04
## ASV2371     -3.120574e-38 -1.883330e-04 -1.971794e-04 -2.059733e-04
## ASV0024      3.056467e-39  1.289947e-05  1.321128e-05  1.350591e-05
## ASV2452      4.023230e-38  2.464781e-04  2.577982e-04  2.694945e-04
## ASV2332      7.898870e-40  7.980271e-06  8.380198e-06  8.941252e-06
## ASV2591      5.921995e-40  1.114325e-05  1.169059e-05  1.261564e-05
## ASV0521      5.271635e-38  3.376747e-04  3.537124e-04  3.705257e-04
## ASV5542      1.600784e-38  1.044758e-04  1.093317e-04  1.146239e-04
## ASV0336     -2.531440e-38 -1.521655e-04 -1.592651e-04 -1.663564e-04
## ASV10102     3.682342e-38  2.345592e-04  2.455933e-04  2.572036e-04
## ASV16823    -3.040027e-38 -1.833438e-04 -1.919754e-04 -2.005326e-04
## ASV3104      3.040027e-38  1.833438e-04  1.919608e-04  2.005175e-04
## ASV0781      1.428856e-38  9.034102e-05  9.450487e-05  9.893580e-05
## ASV10899     1.253085e-38  8.505534e-05  8.915119e-05  9.363177e-05
## ASV11222    -3.040027e-38 -1.833438e-04 -1.919508e-04 -2.005075e-04
## ASV11327    -3.040027e-38 -1.833438e-04 -1.919363e-04 -2.004923e-04
## ASV12458    -3.040027e-38 -1.833437e-04 -1.919218e-04 -2.004772e-04
## ASV1636     -2.490636e-38 -1.502776e-04 -1.572064e-04 -1.642160e-04
## ASV1890     -3.007323e-38 -1.826902e-04 -1.912514e-04 -1.998487e-04
## ASV2898      6.377943e-38  3.963772e-04  4.148268e-04  4.339325e-04
## ASV8328     -6.226076e-39 -3.050376e-05 -3.180798e-05 -3.284808e-05
## ASV0709     -5.198536e-38 -3.241989e-04 -3.392523e-04 -3.549343e-04
## ASV0856      7.771543e-39  5.185754e-05  5.434010e-05  5.702795e-05
## ASV0909     -2.335561e-38 -1.373596e-04 -1.434471e-04 -1.496495e-04
## ASV0937     -4.008191e-38 -2.512158e-04 -2.631328e-04 -2.753721e-04
## ASV11390    -3.040027e-38 -1.833437e-04 -1.918906e-04 -2.004450e-04
## ASV11966     1.420327e-38  9.362239e-05  9.808893e-05  1.028851e-04
## ASV12990     7.819545e-39  5.097148e-05  5.329142e-05  5.586505e-05
## ASV14797     3.089629e-38  1.916429e-04  2.004407e-04  2.096500e-04
## ASV14904    -3.040027e-38 -1.833437e-04 -1.918861e-04 -2.004411e-04
## ASV15304     7.030854e-39  4.959226e-05  5.199614e-05  5.469551e-05
## ASV16696    -3.040027e-38 -1.833437e-04 -1.918741e-04 -2.004288e-04
## ASV1690      1.419706e-38  9.474152e-05  9.931727e-05  1.042276e-04
## ASV2029      8.151639e-38  5.078098e-04  5.314942e-04  5.560382e-04
## ASV2834      4.329441e-38  2.718513e-04  2.846539e-04  2.979147e-04
## ASV4003      1.121142e-38  7.786970e-05  8.167422e-05  8.586279e-05
## ASV4064      2.989265e-38  1.881080e-04  1.969629e-04  2.061576e-04
## ASV4294      9.589711e-39  6.672512e-05  6.997953e-05  7.357547e-05
## ASV4609     -1.530065e-39 -7.762320e-06 -8.186518e-06 -8.475157e-06
## ASV6283     -3.040027e-38 -1.833436e-04 -1.918711e-04 -2.004269e-04
## ASV6491     -3.040027e-38 -1.833436e-04 -1.918567e-04 -2.004117e-04
## ASV7453      1.059821e-38  7.257786e-05  7.611077e-05  7.996193e-05
## ASV7959      1.319226e-39  1.437688e-05  1.514588e-05  1.616019e-05
## ASV8219      3.040027e-38  1.833436e-04  1.918463e-04  2.004013e-04
## ASV8547     -3.040027e-38 -1.833435e-04 -1.918319e-04 -2.003861e-04
## ASV9319      1.938115e-38  1.249180e-04  1.307920e-04  1.370458e-04
## ASV9382     -3.040027e-38 -1.833435e-04 -1.918230e-04 -2.003770e-04
## ASV11516    -3.040027e-38 -1.833435e-04 -1.918087e-04 -2.003619e-04
## ASV14377    -3.040027e-38 -1.833435e-04 -1.917944e-04 -2.003468e-04
## ASV1867      4.243133e-38  2.690179e-04  2.817094e-04  2.949647e-04
## ASV1895     -1.045979e-38 -6.238056e-05 -6.521034e-05 -6.808341e-05
## ASV3168      1.850837e-38  1.157063e-04  1.210261e-04  1.266270e-04
## ASV4449      3.739630e-38  2.283226e-04  2.389149e-04  2.497173e-04
## ASV6596      1.994017e-38  1.316258e-04  1.379958e-04  1.447572e-04
## ASV7492     -1.214220e-38 -6.847593e-05 -7.148297e-05 -7.441825e-05
## ASV9854     -1.586802e-38 -9.386466e-05 -9.816982e-05 -1.024536e-04
## ASV6296      3.040027e-38  1.833434e-04  1.917640e-04  2.003152e-04
## ASV4201      8.213575e-39  6.014103e-05  6.323409e-05  6.661837e-05
## ASV0552      7.091608e-38  4.516360e-04  4.730122e-04  4.953663e-04
## ASV3671     -6.933592e-39 -3.719823e-05 -3.879673e-05 -4.028480e-05
## ASV3529     -7.618069e-39 -4.027942e-05 -4.195133e-05 -4.352368e-05
## ASV1060      1.780419e-38  1.123890e-04  1.177293e-04  1.232459e-04
## ASV0239     -4.212994e-38 -2.568408e-04 -2.686115e-04 -2.807192e-04
## ASV5711     -3.858562e-38 -2.356699e-04 -2.465581e-04 -2.577102e-04
## ASV4152     -5.028716e-38 -3.101244e-04 -3.245655e-04 -3.393988e-04
## ASV1461      4.545945e-38  2.794286e-04  2.922381e-04  3.055316e-04
## ASV2877      3.640261e-38  2.260808e-04  2.366048e-04  2.474912e-04
## ASV0012      2.642182e-38  1.681247e-04  1.761872e-04  1.845102e-04
## ASV9823      1.022522e-38  5.491223e-05  5.737961e-05  5.960893e-05
## ASV0008      2.903262e-38  1.838244e-04  1.925860e-04  2.016372e-04
## ASV7832     -3.117744e-38 -1.918865e-04 -2.007856e-04 -2.099445e-04
## ASV1915      1.884721e-39  1.555624e-05  1.640000e-05  1.735125e-05
## ASV0055      2.110467e-38  1.309606e-04  1.370952e-04  1.433982e-04
## ASV0032      5.174495e-38  3.212870e-04  3.361508e-04  3.516213e-04
## ASV2977     -4.236458e-38 -2.605542e-04 -2.726631e-04 -2.850856e-04
## ASV0466      4.341784e-38  2.647160e-04  2.768930e-04  2.893841e-04
## ASV3866      4.428837e-38  2.799932e-04  2.931906e-04  3.069432e-04
## ASV0040      5.852469e-38  3.702257e-04  3.877686e-04  4.059730e-04
## ASV0496     -2.206917e-39 -2.048367e-05 -2.167057e-05 -2.302427e-05
## ASV0052      7.282631e-38  4.549140e-04  4.761115e-04  4.981632e-04
## ASV3828     -4.522951e-38 -2.794751e-04 -2.924379e-04 -3.058344e-04
## ASV1930      2.768340e-38  1.755397e-04  1.837902e-04  1.924315e-04
## ASV2126      4.533398e-38  2.832972e-04  2.965258e-04  3.102625e-04
## ASV0793      2.607435e-38  1.681727e-04  1.762983e-04  1.847407e-04
## ASV0299     -2.003054e-38 -1.209158e-04 -1.263369e-04 -1.319662e-04
## ASV0208      4.123216e-38  2.660708e-04  2.787463e-04  2.920934e-04
## ASV0511     -2.426196e-38 -1.458480e-04 -1.523633e-04 -1.591176e-04
## ASV1123     -3.131395e-38 -1.900407e-04 -1.986913e-04 -2.076050e-04
## ASV0099     -1.685390e-38 -1.015966e-04 -1.062961e-04 -1.110328e-04
## ASV0752     -2.883957e-39 -2.217720e-05 -2.332035e-05 -2.461213e-05
## ASV0883      1.221272e-40  2.648836e-06  2.819829e-06  3.046310e-06
## ASV0683      3.687287e-38  2.360612e-04  2.472954e-04  2.590477e-04
## ASV4117     -4.545179e-38 -2.803153e-04 -2.933309e-04 -3.067386e-04
## ASV2172      1.665364e-38  1.049916e-04  1.099263e-04  1.150672e-04
## ASV0330     -3.022947e-38 -1.878925e-04 -1.967340e-04 -2.058078e-04
## ASV0728      2.813973e-38  1.793898e-04  1.879406e-04  1.968307e-04
## ASV0499      5.569071e-38  3.563560e-04  3.733098e-04  3.910500e-04
## ASV0120     -6.313502e-38 -3.958296e-04 -4.143504e-04 -4.336113e-04
## ASV1446      6.044190e-39  3.285861e-05  3.423495e-05  3.556726e-05
## ASV17171    -4.305784e-38 -2.663911e-04 -2.787829e-04 -2.915696e-04
## ASV0533      1.169723e-38  7.597339e-05  7.962429e-05  8.346475e-05
## ASV2495     -1.703725e-38 -1.080509e-04 -1.131807e-04 -1.185179e-04
## ASV5582      1.573573e-38  9.440387e-05  9.865464e-05  1.030206e-04
## ASV1488      1.333731e-38  9.411052e-05  9.859292e-05  1.036801e-04
## ASV0682      3.878487e-38  2.493205e-04  2.611769e-04  2.736445e-04
## ASV0068     -1.569197e-39 -1.281555e-05 -1.359875e-05 -1.438280e-05
## ASV1987     -2.040273e-38 -1.346534e-04 -1.411786e-04 -1.480919e-04
## ASV0035      8.741778e-39  4.928184e-05  5.129493e-05  5.338500e-05
## ASV7192     -2.954758e-38 -1.797012e-04 -1.879473e-04 -1.964036e-04
## ASV0873      4.983130e-39  2.705754e-05  2.817059e-05  2.926928e-05
## ASV4749      3.649700e-39  1.664750e-05  1.713929e-05  1.760617e-05
## ASV2174      2.827707e-38  1.648899e-04  1.723791e-04  1.797957e-04
## ASV1476     -2.364743e-38 -1.468897e-04 -1.537905e-04 -1.608811e-04
## ASV0740     -5.655336e-38 -3.602337e-04 -3.773454e-04 -3.951880e-04
## ASV0170      1.225668e-38  7.630042e-05  7.987677e-05  8.356572e-05
## ASV2466     -5.252633e-38 -3.277083e-04 -3.430180e-04 -3.588939e-04
## ASV1709      4.103967e-38  2.537808e-04  2.655716e-04  2.777430e-04
## ASV6170     -3.701779e-38 -2.148484e-04 -2.249753e-04 -2.346130e-04
## ASV3673      4.233390e-38  2.555865e-04  2.676382e-04  2.796178e-04
## ASV1745      3.214905e-39  1.354176e-05  1.418283e-05  1.452780e-05
## ASV0380     -3.001704e-38 -1.696603e-04 -1.776105e-04 -1.849796e-04
## ASV0426     -9.429897e-39 -5.381484e-05 -5.639556e-05 -5.876094e-05
## ASV0202     -1.061039e-38 -5.643793e-05 -5.866934e-05 -6.087087e-05
## ASV6350     -3.682451e-38 -2.138252e-04 -2.238667e-04 -2.334650e-04
## ASV0713     -2.510054e-38 -1.577558e-04 -1.651844e-04 -1.728910e-04
## ASV1822      4.504880e-39  3.367713e-05  3.521687e-05  3.711599e-05
## ASV4569      4.087268e-38  2.504265e-04  2.621259e-04  2.740376e-04
## ASV0030     -8.372670e-39 -5.693517e-05 -5.977070e-05 -6.276719e-05
## ASV0331      1.553491e-38  1.027274e-04  1.076756e-04  1.129551e-04
## ASV2981      3.971736e-38  2.557381e-04  2.678093e-04  2.805931e-04
## ASV0828     -2.616058e-38 -1.702620e-04 -1.783508e-04 -1.869580e-04
## ASV2440      6.289782e-38  4.012742e-04  4.202426e-04  4.401356e-04
## ASV3006     -3.040027e-38 -1.722930e-04 -1.803573e-04 -1.878701e-04
## ASV3875     -3.040027e-38 -1.722928e-04 -1.803438e-04 -1.878570e-04
## ASV4511      1.544893e-38  9.977457e-05  1.045386e-04  1.095515e-04
## ASV4700     -3.040027e-38 -1.722927e-04 -1.803305e-04 -1.878439e-04
## ASV5804     -3.040027e-38 -1.722926e-04 -1.803170e-04 -1.878308e-04
## ASV6826      2.879466e-38  1.849621e-04  1.937316e-04  2.029680e-04
## ASV7280      2.393345e-38  1.596199e-04  1.671595e-04  1.753942e-04
## ASV7535     -3.040027e-38 -1.722925e-04 -1.803098e-04 -1.878246e-04
## ASV0651     -2.961384e-38 -1.814351e-04 -1.897215e-04 -1.983150e-04
## ASV0913      3.794294e-38  2.416629e-04  2.531138e-04  2.650829e-04
## ASV10832    -3.040027e-38 -1.722924e-04 -1.802970e-04 -1.878121e-04
## ASV1117     -5.631066e-38 -3.460411e-04 -3.622954e-04 -3.788127e-04
## ASV11329     1.146426e-38  8.543120e-05  8.963651e-05  9.447274e-05
## ASV13209    -3.629118e-39 -8.176461e-06 -8.471091e-06 -8.173830e-06
## ASV1345      6.318447e-39  4.720438e-05  4.950723e-05  5.216654e-05
## ASV1719     -3.040027e-38 -1.722921e-04 -1.802759e-04 -1.877923e-04
## ASV1886      3.242222e-38  1.973973e-04  2.066096e-04  2.159453e-04
## ASV2158     -9.398753e-39 -4.345148e-05 -4.535650e-05 -4.673398e-05
## ASV2189      3.410635e-38  2.126351e-04  2.226309e-04  2.329335e-04
## ASV2257      2.584074e-38  1.579079e-04  1.653766e-04  1.728852e-04
## ASV2283      3.040027e-38  1.722918e-04  1.802471e-04  1.877635e-04
## ASV2328      3.040027e-38  1.722917e-04  1.802338e-04  1.877503e-04
## ASV2434     -4.282884e-38 -2.568734e-04 -2.688928e-04 -2.808591e-04
## ASV2648      3.040027e-38  1.722915e-04  1.802054e-04  1.877214e-04
## ASV2698      3.969934e-38  2.495756e-04  2.613377e-04  2.735387e-04
## ASV2775      5.017817e-38  3.013682e-04  3.152050e-04  3.292143e-04
## ASV3171      3.040027e-38  1.722913e-04  1.801785e-04  1.876936e-04
## ASV3227      3.740920e-38  2.236891e-04  2.338985e-04  2.442396e-04
## ASV3397      1.862479e-39  1.790574e-05  1.886333e-05  2.002907e-05
## ASV3444      4.180246e-38  2.482199e-04  2.597446e-04  2.711794e-04
## ASV3556      3.040027e-38  1.722911e-04  1.801450e-04  1.876594e-04
## ASV3606     -3.040027e-38 -1.722909e-04 -1.801319e-04 -1.876462e-04
## ASV4190      3.521442e-38  2.206988e-04  2.311147e-04  2.418763e-04
## ASV4197      4.290482e-38  2.563513e-04  2.682446e-04  2.801221e-04
## ASV4722      3.727856e-38  2.302739e-04  2.410460e-04  2.520979e-04
## ASV4765      8.670616e-39  6.017957e-05  6.298733e-05  6.617390e-05
## ASV4809      3.040027e-38  1.722907e-04  1.800997e-04  1.876132e-04
## ASV4846      2.572609e-38  1.641477e-04  1.718400e-04  1.799616e-04
## ASV4903     -9.356722e-39 -4.349163e-05 -4.533343e-05 -4.673093e-05
## ASV4944     -3.040027e-38 -1.722904e-04 -1.800863e-04 -1.876005e-04
## ASV5151     -8.791479e-39 -6.825671e-05 -7.171519e-05 -7.568530e-05
## ASV5413     -3.040027e-38 -1.722902e-04 -1.800764e-04 -1.875911e-04
## ASV5537     -3.040027e-38 -1.722901e-04 -1.800634e-04 -1.875780e-04
## ASV5688      3.040027e-38  1.722899e-04  1.800505e-04  1.875648e-04
## ASV5752      1.243878e-38  8.664077e-05  9.090627e-05  9.553766e-05
## ASV6122     -3.040027e-38 -1.722898e-04 -1.800408e-04 -1.875555e-04
## ASV6135      3.040027e-38  1.722896e-04  1.800279e-04  1.875423e-04
## ASV6188     -3.040027e-38 -1.722895e-04 -1.800150e-04 -1.875292e-04
## ASV6216      4.291012e-38  2.560754e-04  2.678352e-04  2.796839e-04
## ASV6242      3.040027e-38  1.722892e-04  1.799879e-04  1.875011e-04
## ASV6383      3.040027e-38  1.722891e-04  1.799751e-04  1.874879e-04
## ASV6781      3.040027e-38  1.722889e-04  1.799622e-04  1.874748e-04
## ASV6799     -3.040027e-38 -1.722888e-04 -1.799494e-04 -1.874616e-04
## ASV7374     -3.040027e-38 -1.722886e-04 -1.799366e-04 -1.874485e-04
## ASV7539     -3.040027e-38 -1.722885e-04 -1.799239e-04 -1.874353e-04
## ASV8591     -3.040027e-38 -1.722883e-04 -1.799111e-04 -1.874222e-04
## ASV8637      3.040027e-38  1.722882e-04  1.798984e-04  1.874090e-04
## ASV12796    -3.040027e-38 -1.722880e-04 -1.798857e-04 -1.873959e-04
## ASV1934      3.168520e-38  1.996893e-04  2.090798e-04  2.188601e-04
## ASV22549    -2.606906e-40  1.244300e-05  1.342050e-05  1.470664e-05
## ASV29857    -3.040027e-38 -1.722878e-04 -1.798734e-04 -1.873835e-04
## ASV3215      3.810256e-38  2.428910e-04  2.544305e-04  2.664793e-04
## ASV3236     -3.040027e-38 -1.722877e-04 -1.798599e-04 -1.873695e-04
## ASV3954     -3.040027e-38 -1.722875e-04 -1.798473e-04 -1.873564e-04
## ASV4850      3.040027e-38  1.722874e-04  1.798346e-04  1.873432e-04
## ASV5225      3.040027e-38  1.722872e-04  1.798220e-04  1.873301e-04
## ASV5532     -3.040027e-38 -1.722870e-04 -1.798094e-04 -1.873169e-04
## ASV7258      7.356746e-40  2.096691e-05  2.247931e-05  2.431010e-05
## ASV9474     -1.829704e-38 -9.671518e-05 -1.007003e-04 -1.045402e-04
## ASV11857    -3.040027e-38 -1.722867e-04 -1.797924e-04 -1.872997e-04
## ASV1202     -3.040027e-38 -1.722865e-04 -1.797798e-04 -1.872865e-04
## ASV14742     1.797837e-38  1.229611e-04  1.290531e-04  1.355558e-04
## ASV16652     9.184402e-39  6.447254e-05  6.775274e-05  7.120957e-05
## ASV2019      4.207641e-38  2.538784e-04  2.654616e-04  2.773436e-04
## ASV2410     -3.812021e-38 -2.364654e-04 -2.474735e-04 -2.588825e-04
## ASV2718      3.875721e-38  2.513306e-04  2.633536e-04  2.760030e-04
## ASV2738      4.796396e-38  2.869577e-04  2.999199e-04  3.131995e-04
## ASV2876      3.040027e-38  1.722862e-04  1.797522e-04  1.872575e-04
## ASV3177      3.040027e-38  1.722861e-04  1.797397e-04  1.872444e-04
## ASV4367      3.040027e-38  1.722859e-04  1.797273e-04  1.872312e-04
## ASV4635      7.220246e-39  6.014443e-05  6.345972e-05  6.710952e-05
## ASV4896     -4.249857e-40  1.424251e-05  1.549670e-05  1.703018e-05
## ASV4907      1.825889e-38  1.282709e-04  1.348030e-04  1.417369e-04
## ASV5230     -3.040027e-38 -1.722855e-04 -1.797265e-04 -1.872314e-04
## ASV6509     -3.040027e-38 -1.722854e-04 -1.797140e-04 -1.872183e-04
## ASV7376     -3.040027e-38 -1.722852e-04 -1.797016e-04 -1.872052e-04
## ASV8163     -3.040027e-38 -1.722851e-04 -1.796893e-04 -1.871920e-04
## ASV8195     -3.040027e-38 -1.722849e-04 -1.796769e-04 -1.871789e-04
## ASV8923      1.564948e-38  1.068608e-04  1.121893e-04  1.178197e-04
## ASV9666     -2.728745e-38 -1.524889e-04 -1.589364e-04 -1.654588e-04
## ASV1482      2.477237e-38  1.599956e-04  1.676645e-04  1.756879e-04
## ASV2726      3.190156e-38  2.073437e-04  2.173428e-04  2.278040e-04
## ASV3281     -3.040027e-38 -1.722846e-04 -1.796637e-04 -1.871653e-04
## ASV4235     -3.040027e-38 -1.722844e-04 -1.796514e-04 -1.871521e-04
## ASV4808      4.286934e-38  2.576208e-04  2.692390e-04  2.812451e-04
## ASV4861     -4.283689e-38 -2.569623e-04 -2.685200e-04 -2.804781e-04
## ASV5276      4.241240e-38  2.547652e-04  2.662252e-04  2.780818e-04
## ASV5837      3.436592e-38  2.171136e-04  2.273516e-04  2.380270e-04
## ASV7098      3.525946e-38  2.218694e-04  2.322815e-04  2.431440e-04
## ASV8451     -3.040027e-38 -1.722841e-04 -1.795945e-04 -1.870907e-04
## ASV8694     -3.040027e-38 -1.722839e-04 -1.795823e-04 -1.870776e-04
## ASV0905     -1.429364e-38 -9.329624e-05 -9.778933e-05 -1.024796e-04
## ASV2900      3.647573e-38  2.115027e-04  2.206631e-04  2.301237e-04
## ASV3963     -2.964512e-38 -1.674774e-04 -1.745248e-04 -1.817804e-04
## ASV0041     -2.938907e-38 -1.910150e-04 -2.002855e-04 -2.099325e-04
## ASV1865      2.859714e-38  1.922027e-04  2.017124e-04  2.117184e-04
## ASV1140      2.402015e-38  1.578750e-04  1.655903e-04  1.736193e-04
## ASV1179      3.553674e-38  2.266164e-04  2.373775e-04  2.486068e-04
## ASV0279      5.181018e-38  3.191382e-04  3.338870e-04  3.491535e-04
## ASV0043     -3.287927e-39 -2.728768e-05 -2.889292e-05 -3.059274e-05
## ASV2097     -2.989356e-38 -1.778832e-04 -1.857662e-04 -1.939689e-04
## ASV0309     -1.502889e-38 -8.951054e-05 -9.360783e-05 -9.772994e-05
## ASV0607      6.090462e-38  3.872183e-04  4.054829e-04  4.246113e-04
## ASV0025     -6.402158e-38 -4.094505e-04 -4.289748e-04 -4.493213e-04
## ASV2284     -1.239649e-38 -6.594964e-05 -6.885114e-05 -7.148882e-05
## ASV0556      9.864971e-39  6.962951e-05  7.304822e-05  7.682878e-05
## ASV5040      2.597255e-38  1.442643e-04  1.502158e-04  1.563301e-04
## ASV2924     -2.753971e-38 -1.545292e-04 -1.609669e-04 -1.676041e-04
## ASV1331      7.975941e-38  4.979844e-04  5.212729e-04  5.454273e-04
## ASV0506     -3.805681e-38 -2.275302e-04 -2.379983e-04 -2.485213e-04
## ASV1514      5.945817e-38  3.735752e-04  3.911120e-04  4.093333e-04
## ASV2144      5.053533e-38  3.144253e-04  3.290924e-04  3.442866e-04
## ASV2265      6.654328e-38  4.172105e-04  4.367897e-04  4.571073e-04
## ASV5156      1.612468e-38  9.050394e-05  9.453452e-05  9.842300e-05
## ASV5534      1.360131e-38  7.326034e-05  7.643030e-05  7.940475e-05
## ASV5747      1.579865e-53 -1.311884e-05 -1.399834e-05 -1.527955e-05
## ASV6657      3.123704e-38  1.887069e-04  1.974487e-04  2.062918e-04
## ASV0658     -3.561795e-38 -2.126849e-04 -2.224277e-04 -2.322519e-04
## ASV0716      8.915064e-39  5.403155e-05  5.644381e-05  5.897131e-05
## ASV1657      1.640683e-38  9.144010e-05  9.544791e-05  9.933527e-05
## ASV1885      1.244497e-39 -4.291161e-06 -4.758734e-06 -5.560697e-06
## ASV2333      7.434581e-38  4.592082e-04  4.805076e-04  5.025130e-04
## ASV3375      2.871737e-38  1.702679e-04  1.780091e-04  1.858191e-04
## ASV4317      2.845844e-38  1.779640e-04  1.863704e-04  1.950365e-04
## ASV9599      1.711521e-53 -1.311889e-05 -1.404799e-05 -1.533110e-05
## ASV0175     -9.990573e-38 -6.177458e-04 -6.462303e-04 -6.758267e-04
## ASV1032      3.091395e-38  1.831722e-04  1.914487e-04  1.998356e-04
## ASV1235      2.238318e-39  5.793455e-06  5.792628e-06  5.659801e-06
## ASV1262      8.755772e-38  5.435277e-04  5.687207e-04  5.948932e-04
## ASV1320      1.948659e-38  1.322433e-04  1.387505e-04  1.457051e-04
## ASV13797     3.306856e-38  2.007726e-04  2.100250e-04  2.194849e-04
## ASV1491      1.460350e-38  1.030255e-04  1.081789e-04  1.137589e-04
## ASV15014     1.711521e-53 -1.311894e-05 -1.406872e-05 -1.535204e-05
## ASV1510      2.481019e-38  1.644460e-04  1.723766e-04  1.808136e-04
## ASV1551     -1.104080e-38 -6.736372e-05 -7.044861e-05 -7.363247e-05
## ASV1919     -3.858843e-39 -1.117030e-05 -1.137920e-05 -1.128484e-05
## ASV2114      1.713869e-38  9.916048e-05  1.036132e-04  1.080481e-04
## ASV21486     1.711521e-53 -1.311898e-05 -1.406351e-05 -1.534473e-05
## ASV2448      4.569306e-38  2.781553e-04  2.909380e-04  3.040651e-04
## ASV2589      2.237777e-38  1.324460e-04  1.384649e-04  1.445317e-04
## ASV2608      3.614853e-38  2.214876e-04  2.317430e-04  2.422793e-04
## ASV2786      2.875533e-38  1.772234e-04  1.854551e-04  1.939497e-04
## ASV2827      3.773243e-38  2.325524e-04  2.433649e-04  2.544907e-04
## ASV2872      3.188979e-38  1.896524e-04  1.982353e-04  2.069490e-04
## ASV3125      3.747887e-38  2.248794e-04  2.350891e-04  2.455335e-04
## ASV3247      4.057156e-38  2.448711e-04  2.560190e-04  2.674600e-04
## ASV3451      1.711521e-53 -1.311904e-05 -1.413441e-05 -1.542032e-05
## ASV3465     -2.469012e-39 -2.772178e-05 -2.936067e-05 -3.131599e-05
## ASV3809      2.403302e-38  1.416377e-04  1.479369e-04  1.543761e-04
## ASV4006      5.058067e-38  3.053694e-04  3.192106e-04  3.334683e-04
## ASV4046      3.617860e-38  2.168035e-04  2.265832e-04  2.366346e-04
## ASV4938     -2.155665e-40 -1.448971e-05 -1.559394e-05 -1.694862e-05
## ASV5435      1.711521e-53 -1.311911e-05 -1.415703e-05 -1.544348e-05
## ASV5605      1.609979e-38  8.976807e-05  9.363352e-05  9.745170e-05
## ASV5635      1.711521e-53 -1.311914e-05 -1.416081e-05 -1.544694e-05
## ASV5743      4.497092e-38  2.737182e-04  2.862712e-04  2.991928e-04
## ASV6627      1.711521e-53 -1.311916e-05 -1.417318e-05 -1.545992e-05
## ASV6785      1.711521e-53 -1.311918e-05 -1.417140e-05 -1.545764e-05
## ASV7368      4.761317e-38  2.972209e-04  3.110812e-04  3.255017e-04
## ASV9118      1.508129e-38  8.440220e-05  8.801723e-05  9.163061e-05
## ASV9135      1.247077e-38  6.632859e-05  6.903961e-05  7.168386e-05
## ASV9435      2.510395e-38  1.448377e-04  1.511676e-04  1.575797e-04
## ASV9671      1.579865e-53 -1.311923e-05 -1.419412e-05 -1.548141e-05
## ASV0387     -5.040080e-38 -3.037061e-04 -3.174984e-04 -3.316564e-04
## ASV0454     -4.962213e-38 -3.017893e-04 -3.155977e-04 -3.298085e-04
## ASV0751     -3.309851e-38 -1.977330e-04 -2.066223e-04 -2.157489e-04
## ASV1081      1.277394e-38  8.087499e-05  8.471762e-05  8.868612e-05
## ASV1332      2.670614e-38  1.647321e-04  1.723421e-04  1.802115e-04
## ASV2659      4.138730e-38  2.618769e-04  2.741672e-04  2.870090e-04
## ASV2979      4.574727e-38  2.746782e-04  2.870286e-04  2.997704e-04
## ASV4184      2.022738e-38  1.128542e-04  1.176046e-04  1.223914e-04
## ASV6198      1.634206e-38  9.655324e-05  1.008647e-04  1.052823e-04
## ASV7454      2.972525e-38  1.785556e-04  1.866058e-04  1.948933e-04
## ASV8198      1.381746e-38  7.328811e-05  7.619563e-05  7.909289e-05
## ASV0855      6.318760e-38  3.954832e-04  4.139411e-04  4.331621e-04
## ASV10092     2.818463e-38  1.689544e-04  1.765583e-04  1.844035e-04
## ASV1532      3.358332e-38  2.169000e-04  2.272754e-04  2.381730e-04
## ASV2553      8.400286e-38  5.251392e-04  5.496222e-04  5.751129e-04
## ASV2741      3.236422e-38  2.108671e-04  2.210488e-04  2.317141e-04
## ASV4095      1.650114e-38  1.144302e-04  1.202262e-04  1.263404e-04
## ASV5295      2.695222e-38  1.560140e-04  1.628012e-04  1.697398e-04
## ASV5787      1.711521e-53 -1.311936e-05 -1.424539e-05 -1.553562e-05
## ASV9455      3.404879e-38  2.054058e-04  2.146439e-04  2.242405e-04
## ASV10879     3.459155e-38  2.124244e-04  2.221745e-04  2.323062e-04
## ASV3997      2.228766e-38  1.466766e-04  1.537860e-04  1.612595e-04
## ASV6760      9.272111e-39  4.405984e-05  4.555901e-05  4.699891e-05
## ASV6990      2.610804e-38  1.547260e-04  1.615858e-04  1.686744e-04
## ASV9560      1.690264e-38  9.678748e-05  1.009320e-04  1.051940e-04
## ASV0220      1.372524e-38  8.677118e-05  9.093000e-05  9.519444e-05
## ASV2518      3.270863e-38  2.066836e-04  2.163895e-04  2.265350e-04
## ASV3615      5.255024e-38  3.244373e-04  3.393609e-04  3.549023e-04
## ASV0075      1.248383e-38  7.550417e-05  7.890928e-05  8.244435e-05
## ASV8070      8.545617e-39  4.102726e-05  4.241214e-05  4.378169e-05
## ASV1658      2.564588e-38  1.544552e-04  1.614312e-04  1.686397e-04
## ASV0773      4.147203e-38  2.529263e-04  2.644739e-04  2.764343e-04
## ASV0799      1.308621e-39  8.871714e-06  9.256701e-06  9.717971e-06
## ASV1839     -9.031958e-39 -5.252963e-05 -5.484532e-05 -5.718366e-05
## ASV0265      3.621898e-38  2.391929e-04  2.509005e-04  2.631781e-04
## ASV3741      1.552936e-38  9.436252e-05  9.867998e-05  1.031141e-04
## ASV0847      5.380913e-38  3.355617e-04  3.512454e-04  3.674892e-04
## ASV1026      5.791672e-38  3.596241e-04  3.762813e-04  3.935976e-04
## ASV1222     -2.006763e-38 -1.125936e-04 -1.172658e-04 -1.220932e-04
## ASV0729      7.995788e-39  5.045008e-05  5.283444e-05  5.530812e-05
## ASV0143     -4.554584e-38 -2.755652e-04 -2.880105e-04 -3.009080e-04
## ASV1328      1.197601e-38  7.958800e-05  8.353390e-05  8.765046e-05
## ASV9078     -8.638951e-39 -6.808722e-05 -7.187410e-05 -7.589032e-05
## ASV0027     -6.129045e-38 -3.916043e-04 -4.102290e-04 -4.296638e-04
## ASV0546     -2.867009e-38 -1.714904e-04 -1.791583e-04 -1.870831e-04
## ASV1136      7.053137e-38  4.373300e-04  4.575328e-04  4.785859e-04
## ASV3081      3.320036e-38  2.065641e-04  2.161614e-04  2.261600e-04
## ASV0531      1.394782e-38  9.201229e-05  9.656765e-05  1.012806e-04
## ASV2525      1.990986e-38  1.211271e-04  1.265624e-04  1.322714e-04
## ASV1083     -8.493520e-39 -4.482344e-05 -4.654032e-05 -4.829963e-05
## ASV0424      1.227119e-38  7.556593e-05  7.909195e-05  8.270246e-05
## ASV0644     -1.733463e-53  1.078556e-05  1.175166e-05  1.281589e-05
## ASV6007      1.492095e-53 -1.278890e-05 -1.395787e-05 -1.522235e-05
## ASV0564      1.585796e-38  1.064864e-04  1.117949e-04  1.173360e-04
## ASV1938      2.007382e-38  1.157617e-04  1.207125e-04  1.258369e-04
## ASV6516     -4.277777e-38 -2.664826e-04 -2.788734e-04 -2.917595e-04
## ASV0503     -5.241223e-38 -3.135084e-04 -3.274573e-04 -3.419290e-04
## ASV6913     -5.220210e-38 -3.170393e-04 -3.313793e-04 -3.463221e-04
## ASV0164     -3.805648e-38 -2.431961e-04 -2.547229e-04 -2.668062e-04
## ASV1576      4.761563e-38  2.955914e-04  3.092526e-04  3.235136e-04
## ASV1725      2.125365e-38  1.439689e-04  1.511718e-04  1.587108e-04
## ASV4501      2.183865e-38  1.258433e-04  1.311842e-04  1.367369e-04
## ASV10678    -4.213446e-38 -2.618532e-04 -2.739879e-04 -2.866136e-04
## ASV0944      3.325204e-38  2.130455e-04  2.231876e-04  2.338001e-04
## ASV2292      5.476757e-38  3.369694e-04  3.524384e-04  3.685077e-04
## ASV1090      3.521312e-38  2.193343e-04  2.294440e-04  2.400502e-04
## ASV9117     -1.897843e-38 -1.067065e-04 -1.111374e-04 -1.157246e-04
## ASV0285     -1.878554e-38 -1.309412e-04 -1.376330e-04 -1.446783e-04
## ASV0463     -3.568047e-38 -2.146018e-04 -2.241740e-04 -2.341400e-04
## ASV3199      3.134678e-38  1.861376e-04  1.943390e-04  2.028676e-04
## ASV0150     -1.103024e-38 -7.491271e-05 -7.866313e-05 -8.259991e-05
## ASV6583     -1.892061e-38 -1.076607e-04 -1.121700e-04 -1.168758e-04
## ASV0392      2.792587e-38  1.737663e-04  1.818185e-04  1.902065e-04
## ASV14007    -3.459648e-38 -2.120739e-04 -2.217904e-04 -2.318563e-04
## ASV0177     -1.987566e-38 -1.177432e-04 -1.228672e-04 -1.282325e-04
## ASV6448     -1.213724e-38 -8.993383e-05 -9.479157e-05 -9.987125e-05
## ASV5399     -3.657760e-39 -3.558434e-05 -3.784392e-05 -4.021457e-05
## ASV0277     -6.815782e-39 -4.350637e-05 -4.558269e-05 -4.773804e-05
## ASV2599      1.458945e-38  8.080945e-05  8.410876e-05  8.751257e-05
## ASV13465    -1.217653e-38 -6.461883e-05 -6.715383e-05 -6.972176e-05
## ASV2412      1.749340e-38  1.099724e-04  1.151048e-04  1.204748e-04
## ASV0423      3.278161e-38  2.133763e-04  2.237138e-04  2.345229e-04
## ASV5187      2.373825e-38  1.341847e-04  1.398055e-04  1.456179e-04
## ASV0701     -8.100065e-38 -5.131620e-04 -5.373714e-04 -5.626356e-04
## ASV4248      1.808802e-38  1.235621e-04  1.298019e-04  1.363274e-04
## ASV0519      3.303489e-38  2.135701e-04  2.238092e-04  2.345298e-04
## ASV0764      4.817093e-39  3.511310e-05  3.696097e-05  3.892430e-05
## ASV5385     -4.230483e-38 -2.674728e-04 -2.800790e-04 -2.932267e-04
## ASV3021     -2.693519e-38 -1.563961e-04 -1.631722e-04 -1.701737e-04
## ASV4119     -1.533501e-38 -8.639857e-05 -8.998193e-05 -9.370520e-05
## ASV2534      7.307864e-39  4.185665e-05  4.357858e-05  4.542021e-05
## ASV1061      2.986485e-38  2.006349e-04  2.105983e-04  2.210724e-04
## ASV0670      4.508419e-38  2.856840e-04  2.991687e-04  3.132422e-04
## ASV1384      1.797613e-38  1.220610e-04  1.281894e-04  1.345965e-04
## ASV1981      4.151370e-38  2.662935e-04  2.790074e-04  2.922808e-04
## ASV9632     -1.643466e-38 -8.661093e-05 -8.996029e-05 -9.336665e-05
## ASV4564      1.012326e-38  6.536921e-05  6.850576e-05  7.178553e-05
## ASV5289     -9.454109e-39 -6.110820e-05 -6.404770e-05 -6.712698e-05
## ASV0516      8.568451e-38  5.406652e-04  5.660683e-04  5.925545e-04
## ASV1463     -3.200516e-38 -1.969057e-04 -2.059414e-04 -2.153253e-04
## ASV0969      1.511912e-38  9.171002e-05  9.583997e-05  1.001356e-04
## ASV1113     -3.998190e-38 -2.517163e-04 -2.634702e-04 -2.757738e-04
## ASV1234      4.394788e-40 -8.658594e-06 -9.561379e-06 -1.060414e-05
## ASV3814      8.595295e-39  3.693257e-05  3.790968e-05  3.886880e-05
## ASV1000      4.186067e-38  2.588625e-04  2.707936e-04  2.831979e-04
## ASV0079     -2.429104e-39 -2.060240e-05 -2.182029e-05 -2.310898e-05
## ASV0145      1.504519e-38  8.714534e-05  9.088262e-05  9.476595e-05
## ASV0457     -5.317495e-38 -3.282416e-04 -3.433220e-04 -3.590187e-04
## ASV1485      1.628540e-38  1.050282e-04  1.100600e-04  1.153333e-04
## ASV0535     -1.188618e-38 -6.934424e-05 -7.229753e-05 -7.541032e-05
## ASV0259     -3.416494e-38 -2.143646e-04 -2.243768e-04 -2.348102e-04
## ASV0570      1.362727e-39  1.389048e-05  1.477820e-05  1.573365e-05
## ASV0906      4.485730e-38  2.764802e-04  2.891660e-04  3.023707e-04
## ASV1748     -2.368600e-38 -1.605628e-04 -1.686015e-04 -1.770302e-04
## ASV5520     -1.289010e-38 -9.367005e-05 -9.862666e-05 -1.038343e-04
## ASV2288     -5.252116e-38 -3.257347e-04 -3.408013e-04 -3.564664e-04
## ASV1887     -7.553707e-39 -5.989482e-05 -6.323737e-05 -6.675802e-05
## ASV0374     -1.691508e-38 -1.003876e-04 -1.048321e-04 -1.094255e-04
## ASV0823      5.133624e-38  3.119298e-04  3.260144e-04  3.406941e-04
## ASV0717      2.460724e-38  1.552739e-04  1.626038e-04  1.702135e-04
## ASV0431      1.787548e-38  1.109934e-04  1.161084e-04  1.214540e-04
## ASV1030      6.998089e-38  4.511526e-04  4.727487e-04  4.953537e-04
## ASV1082     -1.049765e-38 -6.657221e-05 -6.971837e-05 -7.299636e-05
## ASV2684      4.864533e-39  4.123904e-05  4.363475e-05  4.616566e-05
## ASV0051      6.303534e-38  3.975477e-04  4.162891e-04  4.357817e-04
## ASV0513      2.399094e-39  1.829233e-05  1.930843e-05  2.037829e-05
## ASV0581      8.083178e-38  5.120212e-04  5.361920e-04  5.613964e-04
## ASV7282      1.252159e-38  8.585091e-05  9.018453e-05  9.474989e-05
## ASV3009     -4.453000e-38 -2.805717e-04 -2.937355e-04 -3.074644e-04
## ASV2106     -2.406350e-38 -1.432830e-04 -1.496167e-04 -1.562217e-04
## ASV1012      1.317516e-38  8.913298e-05  9.357763e-05  9.823619e-05
## ASV0921     -1.329964e-39 -6.442460e-06 -6.628941e-06 -6.832475e-06
## ASV0010     -6.226606e-38 -3.979187e-04 -4.168181e-04 -4.365706e-04
## ASV1178      7.543074e-40  8.699665e-06  9.299719e-06  9.923258e-06
## ASV2848     -3.520821e-38 -2.143711e-04 -2.241027e-04 -2.342367e-04
## ASV0586      9.140052e-38  5.799936e-04  6.073702e-04  6.359736e-04
## ASV4225      1.525470e-39  2.631119e-05  2.829154e-05  3.040223e-05
## ASV2156     -3.821022e-38 -2.425416e-04 -2.540083e-04 -2.659753e-04
## ASV9778     -2.456204e-38 -1.531226e-04 -1.602277e-04 -1.676363e-04
## ASV0493     -5.482259e-38 -3.366543e-04 -3.520406e-04 -3.680619e-04
## ASV3770      1.078128e-38  5.728667e-05  5.947418e-05  6.175385e-05
## ASV0470      6.543959e-38  4.107423e-04  4.299102e-04  4.499268e-04
## ASV0262     -2.508091e-38 -1.703238e-04 -1.788622e-04 -1.878191e-04
## ASV0998      3.970297e-38  2.518611e-04  2.637363e-04  2.761553e-04
## ASV7708     -1.132383e-38 -6.739976e-05 -7.037636e-05 -7.346189e-05
## ASV0453     -1.537160e-39 -7.726135e-06 -8.007145e-06 -8.301417e-06
## ASV0044      8.214650e-38  5.153606e-04  5.393672e-04  5.644635e-04
## ASV5490      1.344841e-38  8.223103e-05  8.599182e-05  8.987875e-05
## ASV2638      2.997621e-39  2.514719e-05  2.656068e-05  2.809738e-05
## ASV0829     -8.594898e-39 -4.676913e-05 -4.863996e-05 -5.056402e-05
## ASV0601      1.439565e-38  9.338655e-05  9.787412e-05  1.025881e-04
## ASV0234      3.600485e-38  2.273823e-04  2.380823e-04  2.492415e-04
## ASV0133      4.698288e-38  2.952078e-04  3.090311e-04  3.234334e-04
## ASV0323      4.881431e-38  3.124883e-04  3.273877e-04  3.429557e-04
## ASV0854     -4.381738e-39 -2.587106e-05 -2.698975e-05 -2.816210e-05
## ASV0110      6.238672e-38  3.945170e-04  4.131456e-04  4.325377e-04
## ASV0816      3.647516e-39  2.189395e-05  2.284853e-05  2.386203e-05
## ASV1031     -1.048331e-38 -6.082100e-05 -6.341924e-05 -6.613344e-05
## ASV0144     -2.607409e-38 -1.633294e-04 -1.709745e-04 -1.789250e-04
## ASV0020     -1.028366e-38 -7.089775e-05 -7.454296e-05 -7.835843e-05
## ASV0962     -2.122252e-38 -1.331507e-04 -1.393683e-04 -1.458488e-04
## ASV0794      3.963597e-38  2.604478e-04  2.731224e-04  2.864098e-04
## ASV7117     -2.141849e-38 -1.322425e-04 -1.383033e-04 -1.446313e-04
## ASV1008     -1.467436e-38 -9.587786e-05 -1.005018e-04 -1.053730e-04
## ASV0096      6.715224e-38  4.246097e-04  4.446105e-04  4.654738e-04
## ASV0128     -3.897035e-38 -2.535711e-04 -2.658442e-04 -2.786972e-04
## ASV5232      3.027018e-38  1.976235e-04  2.071859e-04  2.172085e-04
## ASV0031      2.765044e-39  1.543284e-05  1.604881e-05  1.669783e-05
## ASV1744     -4.501257e-39 -2.645663e-05 -2.764973e-05 -2.887349e-05
## ASV0289      3.767706e-38  2.375022e-04  2.486384e-04  2.602809e-04
## ASV7413     -6.380907e-39 -5.353052e-05 -5.661070e-05 -5.990295e-05
## ASV0822     -4.716991e-38 -2.889269e-04 -3.020832e-04 -3.157773e-04
## ASV8111     -4.169062e-38 -2.535400e-04 -2.650437e-04 -2.770118e-04
## ASV0687      2.759518e-38  1.803490e-04  1.890586e-04  1.982066e-04
## ASV0112      1.120695e-38  6.626672e-05  6.920938e-05  7.222284e-05
## ASV0987      2.225322e-38  1.451913e-04  1.522111e-04  1.595890e-04
## ASV5332     -1.411156e-38 -7.633216e-05 -7.935419e-05 -8.249079e-05
## ASV1129     -2.973524e-38 -1.873336e-04 -1.961139e-04 -2.052937e-04
## ASV1274     -9.717767e-39 -6.088997e-05 -6.372582e-05 -6.668755e-05
## ASV0119      5.478743e-38  3.461004e-04  3.623801e-04  3.793683e-04
## ASV0890      1.342358e-38  8.566794e-05  8.972576e-05  9.396864e-05
## ASV0848      7.928293e-38  5.026937e-04  5.263711e-04  5.511363e-04
## ASV5944     -4.378588e-38 -2.734946e-04 -2.862105e-04 -2.994707e-04
## ASV19741    -4.182093e-38 -2.607171e-04 -2.727780e-04 -2.853890e-04
## ASV0504     -4.911402e-38 -3.011804e-04 -3.149004e-04 -3.292084e-04
## ASV2146     -3.209636e-38 -1.938036e-04 -2.024831e-04 -2.115615e-04
## ASV0089     -2.517405e-38 -1.598594e-04 -1.674176e-04 -1.753049e-04
## ASV2301     -2.729800e-38 -1.742063e-04 -1.824661e-04 -1.911095e-04
## ASV2982      7.442762e-39  6.238627e-05  6.600480e-05  6.982271e-05
## ASV0891     -3.502569e-38 -2.192787e-04 -2.294979e-04 -2.401521e-04
## ASV0093      5.691894e-38  3.576318e-04  3.743937e-04  3.918513e-04
## ASV0042      2.755813e-38  1.733148e-04  1.814127e-04  1.898769e-04
## ASV0980      3.856416e-38  2.382160e-04  2.491411e-04  2.605352e-04
## ASV0069     -8.801954e-39 -5.709357e-05 -5.985686e-05 -6.273767e-05
## ASV1364     -6.623203e-39 -3.980354e-05 -4.156295e-05 -4.340418e-05
## ASV0524     -1.027609e-38 -6.746908e-05 -7.072653e-05 -7.417429e-05
## ASV0435      7.471152e-38  4.746404e-04  4.970354e-04  5.204716e-04
## ASV0517     -3.056280e-38 -1.943397e-04 -2.035149e-04 -2.131208e-04
## ASV3167     -1.268383e-38 -8.461120e-05 -8.879437e-05 -9.317567e-05
## ASV4280     -4.995943e-39 -2.943865e-05 -3.071142e-05 -3.204672e-05
## ASV1158      1.708228e-38  1.166270e-04  1.224817e-04  1.286152e-04
## ASV2214      1.425520e-38  8.653353e-05  9.044346e-05  9.452663e-05
## ASV0544     -1.668881e-38 -1.082305e-04 -1.134390e-04 -1.189011e-04
## ASV5326     -3.187033e-39 -1.973078e-05 -2.066397e-05 -2.161668e-05
## ASV3765     -4.494004e-38 -2.833067e-04 -2.965693e-04 -3.104353e-04
## ASV4646      6.121052e-40 -5.135886e-06 -5.754994e-06 -6.452258e-06
## ASV0090      5.184869e-39  3.019867e-05  3.148705e-05  3.282843e-05
## ASV3680      4.341329e-38  2.623641e-04  2.741126e-04  2.863592e-04
## ASV0111      7.565369e-39  4.543073e-05  4.743754e-05  4.953668e-05
## ASV0768      2.548455e-38  1.637378e-04  1.715608e-04  1.797494e-04
## ASV4862     -1.739272e-39 -8.711469e-06 -9.002185e-06 -9.301956e-06
## ASV1742     -3.551583e-38 -2.137701e-04 -2.233400e-04 -2.333025e-04
## ASV3701     -5.809251e-39 -3.079712e-05 -3.198606e-05 -3.320863e-05
## ASV2386     -2.065815e-38 -1.300212e-04 -1.361963e-04 -1.425548e-04
## ASV0375     -4.939936e-38 -3.035516e-04 -3.174091e-04 -3.318785e-04
## ASV2796      1.334889e-38  7.864141e-05  8.207361e-05  8.565371e-05
## ASV1369      3.408110e-38  2.086385e-04  2.181399e-04  2.280631e-04
## ASV10272    -3.040027e-38 -1.894772e-04 -1.983545e-04 -2.075192e-04
## ASV10354    -3.040027e-38 -1.894772e-04 -1.983395e-04 -2.075029e-04
## ASV1067     -2.322149e-39 -1.431954e-05 -1.504592e-05 -1.573431e-05
## ASV1900      6.222341e-38  3.950153e-04  4.136491e-04  4.331400e-04
## ASV4079     -1.036164e-38 -6.719487e-05 -7.049164e-05 -7.388342e-05
## ASV4149      4.409513e-38  2.680736e-04  2.801609e-04  2.927542e-04
## ASV5140     -3.040027e-38 -1.894772e-04 -1.983246e-04 -2.074869e-04
## ASV10782    -1.804520e-39 -7.985936e-06 -8.248907e-06 -8.456150e-06
## ASV4273     -7.479188e-39 -4.418140e-05 -4.616098e-05 -4.816400e-05
## ASV8121      2.868455e-38  1.813753e-04  1.898674e-04  1.987790e-04
## ASV8438     -3.040027e-38 -1.894772e-04 -1.983111e-04 -2.074725e-04
## ASV9390     -3.040027e-38 -1.894772e-04 -1.982962e-04 -2.074563e-04
## ASV1340      4.093787e-38  2.612160e-04  2.735923e-04  2.865494e-04
## ASV2650     -4.569051e-38 -2.823142e-04 -2.952837e-04 -3.087945e-04
## ASV4674      2.278712e-38  1.433735e-04  1.500595e-04  1.570608e-04
## ASV10492    -1.805289e-39 -1.050153e-05 -1.097007e-05 -1.143948e-05
## ASV11430    -3.040027e-38 -1.894772e-04 -1.982740e-04 -2.074322e-04
## ASV12135    -3.040027e-38 -1.894772e-04 -1.982591e-04 -2.074159e-04
## ASV14970    -3.040027e-38 -1.894772e-04 -1.982443e-04 -2.073996e-04
## ASV1954      3.415967e-38  2.158791e-04  2.260130e-04  2.366070e-04
## ASV2613      5.369877e-38  3.370769e-04  3.527735e-04  3.691941e-04
## ASV2757      2.209087e-38  1.345935e-04  1.406765e-04  1.470167e-04
## ASV2909     -3.113541e-38 -1.988667e-04 -2.082970e-04 -2.181755e-04
## ASV2954     -6.464487e-39 -3.937425e-05 -4.116409e-05 -4.301619e-05
## ASV2969      2.886375e-38  1.857963e-04  1.946734e-04  2.039789e-04
## ASV3410      5.666365e-39  3.799766e-05  3.987053e-05  4.185444e-05
## ASV3575      1.564300e-38  9.807127e-05  1.026220e-04  1.073959e-04
## ASV4275      3.536200e-38  2.175093e-04  2.274147e-04  2.377674e-04
## ASV4652      5.307887e-39  3.618649e-05  3.797620e-05  3.989225e-05
## ASV4761      3.526201e-38  2.172617e-04  2.271695e-04  2.375250e-04
## ASV6003      2.522470e-38  1.637208e-04  1.715988e-04  1.798725e-04
## ASV6110     -3.040027e-38 -1.894772e-04 -1.982756e-04 -2.074342e-04
## ASV7427      1.959506e-38  1.225674e-04  1.282442e-04  1.341902e-04
## ASV8092     -3.040027e-38 -1.894772e-04 -1.982659e-04 -2.074237e-04
## ASV8169     -3.040027e-38 -1.894772e-04 -1.982511e-04 -2.074074e-04
## ASV9693      1.301781e-38  8.234276e-05  8.620514e-05  9.024983e-05
## ASV10913     1.384640e-38  8.926582e-05  9.355628e-05  9.803555e-05
## ASV1979     -5.120549e-39 -3.066843e-05 -3.203191e-05 -3.344816e-05
## ASV3772      3.780361e-38  2.345459e-04  2.453390e-04  2.566196e-04
## ASV0113      7.657695e-39  4.707534e-05  4.922771e-05  5.147069e-05
## ASV1800     -2.968267e-39 -1.866785e-05 -1.952611e-05 -2.042222e-05
## ASV2335     -4.067643e-38 -2.485557e-04 -2.598498e-04 -2.716394e-04
## ASV0692      1.261345e-38  8.005816e-05  8.382869e-05  8.777355e-05
## ASV1120      1.632735e-38  1.035699e-04  1.084385e-04  1.135439e-04
## ASV1434     -8.658433e-38 -5.477939e-04 -5.735495e-04 -6.004788e-04
## ASV0076     -9.294980e-39 -6.011025e-05 -6.299708e-05 -6.601931e-05
## ASV0361      6.463148e-38  4.095509e-04  4.288332e-04  4.490010e-04
## ASV2231     -2.017176e-38 -1.344201e-04 -1.410900e-04 -1.480687e-04
## ASV2018     -8.523333e-40 -5.744424e-06 -6.036562e-06 -6.341169e-06
## ASV1529      5.329279e-38  3.414461e-04  3.577029e-04  3.747224e-04
## ASV0841     -3.123463e-39 -1.752123e-05 -1.823866e-05 -1.897822e-05
## ASV2556     -3.299648e-38 -2.061075e-04 -2.156761e-04 -2.256623e-04
## ASV2777      4.323659e-38  2.620276e-04  2.737712e-04  2.860311e-04
## ASV0355      3.338025e-38  2.110406e-04  2.209530e-04  2.313215e-04
## ASV5169     -4.675239e-38 -2.946640e-04 -3.084629e-04 -3.228802e-04
## ASV3091      2.191844e-38  1.409302e-04  1.476619e-04  1.547141e-04
## ASV2435      3.323790e-38  2.090158e-04  2.187870e-04  2.289906e-04
## ASV6822     -2.143986e-38 -1.328274e-04 -1.389371e-04 -1.453105e-04
## ASV12605    -5.095941e-38 -3.207506e-04 -3.357326e-04 -3.514054e-04
## ASV0286     -3.410740e-38 -2.126288e-04 -2.224749e-04 -2.327789e-04
## ASV0074     -4.693796e-40 -7.539247e-06 -8.106975e-06 -8.717547e-06
## ASV2485     -2.061041e-39 -1.518901e-05 -1.601935e-05 -1.690258e-05
## ASV1233     -6.447314e-38 -4.072446e-04 -4.263678e-04 -4.463622e-04
## ASV0356     -3.150438e-38 -1.946276e-04 -2.035442e-04 -2.128736e-04
## ASV2918     -3.966520e-38 -2.475270e-04 -2.589854e-04 -2.709702e-04
## ASV1427      3.429366e-40  1.087565e-06  1.086635e-06  1.079361e-06
## ASV1409      3.677986e-38  2.355730e-04  2.467778e-04  2.585152e-04
## ASV0770      1.280859e-38  7.789181e-05  8.139730e-05  8.505352e-05
## ASV1403     -4.569919e-38 -2.867017e-04 -3.000401e-04 -3.139991e-04
## ASV0314     -2.459058e-38 -1.551907e-04 -1.624581e-04 -1.700591e-04
## ASV0187      1.384455e-39  4.403120e-06  4.399528e-06  4.392392e-06
## ASV0313     -3.380405e-38 -2.115447e-04 -2.213743e-04 -2.316459e-04
## ASV1087      5.713278e-38  3.607247e-04  3.776270e-04  3.953171e-04
## ASV1970      3.456843e-39  2.137077e-05  2.234041e-05  2.336560e-05
## ASV0754      4.598408e-38  2.907054e-04  3.043559e-04  3.186340e-04
## ASV3775     -3.094402e-38 -1.977603e-04 -2.071488e-04 -2.169774e-04
## ASV0132      1.337278e-38  8.407150e-05  8.800227e-05  9.210595e-05
## ASV2329     -7.242003e-39 -5.362889e-05 -5.650280e-05 -5.952373e-05
## ASV0561      4.041917e-38  2.530664e-04  2.648287e-04  2.771209e-04
## ASV0130     -4.822305e-38 -3.062975e-04 -3.207497e-04 -3.358649e-04
## ASV0226      5.486676e-38  3.460439e-04  3.622719e-04  3.792220e-04
## ASV12648    -3.957854e-38 -2.439113e-04 -2.550737e-04 -2.667509e-04
## ASV0204      5.471322e-38  3.450489e-04  3.612018e-04  3.780991e-04
## ASV0767      1.032003e-38  6.235130e-05  6.513602e-05  6.803885e-05
## ASV0335     -2.971859e-38 -1.880594e-04 -1.968913e-04 -2.061319e-04
## ASV5901     -9.805845e-39 -5.776868e-05 -6.028818e-05 -6.291933e-05
## ASV0596     -1.273018e-38 -7.699441e-05 -8.043916e-05 -8.403035e-05
## ASV9271      9.664956e-39  7.057518e-05  7.433041e-05  7.827555e-05
## ASV0904      4.785330e-38  3.051994e-04  3.196594e-04  3.347950e-04
## ASV15270    -1.158588e-38 -8.210538e-05 -8.635581e-05 -9.082010e-05
## ASV0990     -1.337005e-38 -8.545439e-05 -8.951055e-05 -9.375864e-05
## ASV0155     -2.928215e-38 -1.847210e-04 -1.933702e-04 -2.024213e-04
## ASV0086     -3.913130e-40 -2.606845e-06 -2.735864e-06 -2.870738e-06
## ASV2581     -2.542304e-39 -1.543710e-05 -1.612785e-05 -1.684569e-05
## ASV1579     -3.314543e-38 -2.131325e-04 -2.233069e-04 -2.339644e-04
## ASV7730      1.141014e-53 -6.986626e-06 -7.621555e-06 -8.298945e-06
## ASV0897      1.389932e-38  8.971656e-05  9.401641e-05  9.852264e-05
## ASV1975      6.621688e-38  4.176498e-04  4.372145e-04  4.576895e-04
##                                                                    
## (Intercept)  1.201317e-06  1.304023e-06  1.409292e-06  1.515545e-06
## ASV1236      2.209612e-04  2.310066e-04  2.414861e-04  2.524163e-04
## ASV0421     -3.945178e-04 -4.126208e-04 -4.315225e-04 -4.512552e-04
## ASV0691     -3.407092e-04 -3.558923e-04 -3.717037e-04 -3.881651e-04
## ASV0899     -2.425674e-06 -2.211403e-06 -1.958231e-06 -1.661922e-06
## ASV1004      4.464919e-04  4.668998e-04  4.881999e-04  5.104275e-04
## ASV1041     -3.035178e-04 -3.174677e-04 -3.320343e-04 -3.472427e-04
## ASV1058      4.155804e-04  4.346074e-04  4.544699e-04  4.752013e-04
## ASV12542     1.282919e-04  1.340512e-04  1.400531e-04  1.463063e-04
## ASV1294      4.834120e-04  5.056997e-04  5.289801e-04  5.532942e-04
## ASV13113     1.737138e-04  1.820062e-04  1.906956e-04  1.998011e-04
## ASV1318      4.216414e-04  4.409792e-04  4.611685e-04  4.822437e-04
## ASV2269     -1.259421e-04 -1.317442e-04 -1.378035e-04 -1.441306e-04
## ASV2542      2.704180e-04  2.831673e-04  2.965112e-04  3.104769e-04
## ASV2660     -2.435798e-04 -2.546743e-04 -2.662499e-04 -2.783252e-04
## ASV2737     -1.301370e-05 -1.372969e-05 -1.448750e-05 -1.528981e-05
## ASV2840      3.241021e-04  3.388007e-04  3.541312e-04  3.701175e-04
## ASV3053      1.750798e-05  1.826784e-05  1.905786e-05  1.987890e-05
## ASV3077      1.008332e-04  1.054216e-04  1.102094e-04  1.152042e-04
## ASV3134      3.493721e-04  3.659615e-04  3.833366e-04  4.015344e-04
## ASV3140      1.537611e-04  1.610195e-04  1.686161e-04  1.765664e-04
## ASV3579      6.091140e-05  6.393633e-05  6.711715e-05  7.046229e-05
## ASV6119     -1.259219e-04 -1.317221e-04 -1.377793e-04 -1.441041e-04
## ASV7557     -1.259116e-04 -1.317108e-04 -1.377669e-04 -1.440906e-04
## ASV8422      6.848541e-05  7.148765e-05  7.461021e-05  7.785683e-05
## ASV1086     -3.505116e-05 -3.661428e-05 -3.824276e-05 -3.993889e-05
## ASV1310      2.380727e-04  2.490139e-04  2.604391e-04  2.723678e-04
## ASV15750    -5.977283e-05 -6.249837e-05 -6.534162e-05 -6.830709e-05
## ASV16905    -1.259074e-04 -1.317061e-04 -1.377619e-04 -1.440851e-04
## ASV2033      2.345015e-04  2.455316e-04  2.570740e-04  2.691519e-04
## ASV2089      8.624949e-05  9.023633e-05  9.440095e-05  9.875072e-05
## ASV2127      3.422933e-04  3.579533e-04  3.742998e-04  3.913601e-04
## ASV2725      3.881444e-04  4.057181e-04  4.240449e-04  4.431534e-04
## ASV2804     -1.259046e-04 -1.317031e-04 -1.377585e-04 -1.440814e-04
## ASV3075      2.453612e-04  2.566382e-04  2.684153e-04  2.807130e-04
## ASV3327      2.301461e-04  2.409723e-04  2.523018e-04  2.641577e-04
## ASV3342      2.510919e-04  2.628239e-04  2.750928e-04  2.879222e-04
## ASV3532     -2.272041e-04 -2.378374e-04 -2.489591e-04 -2.605906e-04
## ASV3600      2.864238e-04  2.997193e-04  3.136164e-04  3.281408e-04
## ASV4013      2.414357e-04  2.525302e-04  2.641156e-04  2.762121e-04
## ASV4136      2.392339e-04  2.500935e-04  2.614211e-04  2.732344e-04
## ASV4195      1.258896e-04  1.316867e-04  1.377407e-04  1.440619e-04
## ASV4407     -1.258793e-04 -1.316754e-04 -1.377283e-04 -1.440484e-04
## ASV4717      5.837007e-06  5.954865e-06  6.064871e-06  6.165544e-06
## ASV6794      1.277744e-04  1.334068e-04  1.392673e-04  1.453633e-04
## ASV8324     -1.258761e-04 -1.316719e-04 -1.377244e-04 -1.440440e-04
## ASV8981     -3.452457e-05 -3.602251e-05 -3.757761e-05 -3.919130e-05
## ASV9859      9.605902e-05  1.007487e-04  1.056729e-04  1.108437e-04
## ASV0936     -1.974502e-04 -2.065593e-04 -2.160753e-04 -2.260152e-04
## ASV12683    -2.024402e-05 -2.124956e-05 -2.230586e-05 -2.341554e-05
## ASV1293      2.903115e-04  3.035543e-04  3.173735e-04  3.317916e-04
## ASV13055    -3.085399e-05 -3.223471e-05 -3.367218e-05 -3.516824e-05
## ASV17063    -1.258583e-04 -1.316524e-04 -1.377031e-04 -1.440208e-04
## ASV2228      1.258479e-04  1.316411e-04  1.376908e-04  1.440073e-04
## ASV2769     -2.431012e-05 -2.535858e-05 -2.644643e-05 -2.757462e-05
## ASV2803      5.867025e-05  6.121673e-05  6.386279e-05  6.661131e-05
## ASV2896      1.571473e-04  1.644488e-04  1.720822e-04  1.800620e-04
## ASV3062      4.741480e-05  4.976234e-05  5.223020e-05  5.482484e-05
## ASV3107      1.900286e-04  1.988957e-04  2.081684e-04  2.178646e-04
## ASV3265      3.781444e-04  3.954090e-04  4.134269e-04  4.322277e-04
## ASV3666     -8.451924e-06 -8.859618e-06 -9.286694e-06 -9.734061e-06
## ASV4497      8.975956e-05  9.387592e-05  9.817423e-05  1.026619e-04
## ASV6914     -4.431121e-05 -4.640883e-05 -4.860440e-05 -5.090237e-05
## ASV0576     -4.447900e-04 -4.647473e-04 -4.855434e-04 -5.072086e-04
## ASV0673      1.171774e-04  1.228729e-04  1.288490e-04  1.351197e-04
## ASV0772      1.342886e-04  1.404580e-04  1.469010e-04  1.536290e-04
## ASV0862     -1.096120e-04 -1.145216e-04 -1.196367e-04 -1.249647e-04
## ASV0898      1.112075e-04  1.165427e-04  1.221348e-04  1.279961e-04
## ASV0910      2.409628e-04  2.524090e-04  2.643971e-04  2.769525e-04
## ASV0964     -1.623740e-04 -1.697654e-04 -1.774776e-04 -1.855230e-04
## ASV10059     1.132044e-04  1.186375e-04  1.243337e-04  1.303061e-04
## ASV10263    -1.259034e-04 -1.317018e-04 -1.377571e-04 -1.440799e-04
## ASV1088      1.275821e-04  1.336395e-04  1.399843e-04  1.466299e-04
## ASV1101      2.178724e-04  2.279459e-04  2.384703e-04  2.494645e-04
## ASV1183      1.397999e-04  1.463383e-04  1.531761e-04  1.603264e-04
## ASV11956     5.303236e-05  5.527875e-05  5.760766e-05  6.002100e-05
## ASV12774    -1.923236e-05 -2.019214e-05 -2.120097e-05 -2.226143e-05
## ASV1321      5.492731e-05  5.769535e-05  6.060911e-05  6.367670e-05
## ASV13793    -1.258911e-04 -1.316883e-04 -1.377424e-04 -1.440637e-04
## ASV14482    -1.206725e-05 -1.272195e-05 -1.341413e-05 -1.414603e-05
## ASV15483     8.813032e-05  9.225603e-05  9.657218e-05  1.010874e-04
## ASV2062      5.539920e-04  5.796115e-04  6.063797e-04  6.343448e-04
## ASV2132      2.523471e-04  2.642014e-04  2.766054e-04  2.895838e-04
## ASV2413      3.577046e-04  3.740519e-04  3.911147e-04  4.089215e-04
## ASV2490      2.343774e-04  2.449235e-04  2.559154e-04  2.673691e-04
## ASV2594      1.287521e-04  1.346817e-04  1.408763e-04  1.473469e-04
## ASV2822     -1.259077e-04 -1.317065e-04 -1.377623e-04 -1.440856e-04
## ASV2863      2.185787e-04  2.285261e-04  2.389043e-04  2.497300e-04
## ASV2910      2.847463e-04  2.976733e-04  3.111580e-04  3.252219e-04
## ASV2980      1.038532e-04  1.086112e-04  1.135776e-04  1.187606e-04
## ASV3307      1.258905e-04  1.316876e-04  1.377417e-04  1.440630e-04
## ASV3474      1.958050e-04  2.051006e-04  2.148361e-04  2.250322e-04
## ASV3502      4.092834e-04  4.282569e-04  4.480859e-04  4.688067e-04
## ASV4236      2.082324e-04  2.177056e-04  2.275892e-04  2.378990e-04
## ASV4842     -6.930146e-05 -7.254939e-05 -7.594608e-05 -7.949795e-05
## ASV4894     -1.259021e-04 -1.317004e-04 -1.377557e-04 -1.440783e-04
## ASV5290      1.537047e-04  1.608010e-04  1.682150e-04  1.759599e-04
## ASV5501      2.883618e-05  3.015989e-05  3.154274e-05  3.298727e-05
## ASV5795      1.033005e-04  1.081407e-04  1.132044e-04  1.185015e-04
## ASV5987     -1.259059e-04 -1.317046e-04 -1.377602e-04 -1.440834e-04
## ASV6267     -1.258956e-04 -1.316933e-04 -1.377479e-04 -1.440699e-04
## ASV6862      2.412528e-04  2.520578e-04  2.633154e-04  2.750417e-04
## ASV7145      4.319885e-05  4.504142e-05  4.695316e-05  4.893586e-05
## ASV7673     -1.258926e-04 -1.316900e-04 -1.377442e-04 -1.440658e-04
## ASV7789      4.491357e-05  4.716599e-05  4.953653e-05  5.203181e-05
## ASV7809     -1.647237e-05 -1.715590e-05 -1.786213e-05 -1.859120e-05
## ASV8002     -1.258846e-04 -1.316812e-04 -1.377347e-04 -1.440554e-04
## ASV8205      7.182413e-05  7.510103e-05  7.852166e-05  8.209187e-05
## ASV9155     -9.486526e-05 -9.921966e-05 -1.037655e-04 -1.085103e-04
## ASV9221     -1.644049e-05 -1.716239e-05 -1.791260e-05 -1.869185e-05
## ASV9311     -1.258702e-04 -1.316654e-04 -1.377175e-04 -1.440366e-04
## ASV9557     -1.258599e-04 -1.316542e-04 -1.377051e-04 -1.440231e-04
## ASV9936     -1.258495e-04 -1.316429e-04 -1.376927e-04 -1.440096e-04
## ASV1445      2.894128e-04  3.029459e-04  3.171003e-04  3.319034e-04
## ASV4232      2.433840e-04  2.548525e-04  2.668565e-04  2.794206e-04
## ASV6479     -8.857175e-07 -6.799995e-07 -4.412257e-07 -1.657002e-07
## ASV0142     -6.341476e-04 -6.629311e-04 -6.929553e-04 -7.242678e-04
## ASV0378     -2.097653e-04 -2.192682e-04 -2.291785e-04 -2.395114e-04
## ASV1122      3.821871e-04  4.000582e-04  4.187494e-04  4.382970e-04
## ASV0123     -6.212800e-04 -6.494653e-04 -6.788643e-04 -7.095231e-04
## ASV2064      6.271612e-05  6.539880e-05  6.818357e-05  7.107330e-05
## ASV4459     -6.980934e-05 -7.303780e-05 -7.641042e-05 -7.993310e-05
## ASV0448      1.091051e-04  1.144886e-04  1.201447e-04  1.260878e-04
## ASV0397      2.867885e-04  3.001663e-04  3.141546e-04  3.287798e-04
## ASV0485      3.998695e-04  4.182867e-04  4.375230e-04  4.576124e-04
## ASV1566      3.349527e-04  3.505117e-04  3.667749e-04  3.837725e-04
## ASV1365      2.159820e-04  2.259884e-04  2.364458e-04  2.473731e-04
## ASV1065      4.451336e-04  4.658600e-04  4.875288e-04  5.101808e-04
## ASV0722     -9.514748e-06 -9.914478e-06 -1.032912e-05 -1.075911e-05
## ASV12660    -2.093192e-04 -2.187966e-04 -2.286799e-04 -2.389844e-04
## ASV0223     -8.055336e-06 -8.392580e-06 -8.741837e-06 -9.103339e-06
## ASV0229      1.990364e-04  2.084012e-04  2.182009e-04  2.284550e-04
## ASV0877     -7.936131e-05 -8.300972e-05 -8.681806e-05 -9.079251e-05
## ASV0983      4.084912e-04  4.272399e-04  4.468157e-04  4.672519e-04
## ASV0626     -1.341344e-04 -1.399353e-04 -1.459587e-04 -1.522105e-04
## ASV4146     -2.338308e-05 -2.447489e-05 -2.561628e-05 -2.680935e-05
## ASV4175     -2.499093e-04 -2.614800e-04 -2.735703e-04 -2.862017e-04
## ASV2082     -1.718080e-05 -1.809817e-05 -1.906925e-05 -2.009759e-05
## ASV2272      1.794574e-04  1.878116e-04  1.965463e-04  2.056781e-04
## ASV2245     -2.178563e-04 -2.280029e-04 -2.386106e-04 -2.496992e-04
## ASV0590     -1.314366e-04 -1.377734e-04 -1.444192e-04 -1.513893e-04
## ASV0217     -2.030438e-04 -2.117038e-04 -2.206845e-04 -2.299932e-04
## ASV0416      2.037368e-04  2.127933e-04  2.222218e-04  2.320347e-04
## ASV1056      2.418146e-04  2.533483e-04  2.654324e-04  2.780933e-04
## ASV7777     -2.175247e-04 -2.276965e-04 -2.383347e-04 -2.494599e-04
## ASV0455      4.332803e-05  4.542539e-05  4.762475e-05  4.993101e-05
## ASV0604      4.785729e-05  5.037407e-05  5.303215e-05  5.584009e-05
## ASV6100     -2.007160e-04 -2.101126e-04 -2.199409e-04 -2.302200e-04
## ASV11359    -2.227393e-04 -2.329982e-04 -2.437126e-04 -2.549011e-04
## ASV6604      1.586403e-04  1.661214e-04  1.739522e-04  1.821486e-04
## ASV5004     -1.316046e-04 -1.376991e-04 -1.440672e-04 -1.507203e-04
## ASV1483     -1.220537e-04 -1.277631e-04 -1.337342e-04 -1.399786e-04
## ASV9773     -2.567854e-04 -2.687709e-04 -2.813039e-04 -2.944081e-04
## ASV4059      2.375813e-05  2.499169e-05  2.629361e-05  2.766803e-05
## ASV1193      4.171088e-04  4.364962e-04  4.567624e-04  4.779453e-04
## ASV4610     -3.710354e-05 -3.853648e-05 -4.000750e-05 -4.151581e-05
## ASV0742     -1.563680e-04 -1.631989e-04 -1.702986e-04 -1.776751e-04
## ASV1502     -2.496883e-06 -2.755437e-06 -3.038637e-06 -3.348685e-06
## ASV0195     -4.599356e-05 -4.832148e-05 -5.077241e-05 -5.335320e-05
## ASV1213      1.323503e-04  1.382830e-04  1.444639e-04  1.509015e-04
## ASV1648     -1.902229e-04 -1.990875e-04 -2.083559e-04 -2.180454e-04
## ASV6984     -1.420497e-04 -1.486879e-04 -1.556300e-04 -1.628892e-04
## ASV0396     -1.050079e-04 -1.091848e-04 -1.134872e-04 -1.179148e-04
## ASV4297      2.137178e-04  2.233870e-04  2.334706e-04  2.439843e-04
## ASV2622      4.873983e-04  5.096475e-04  5.328677e-04  5.570974e-04
## ASV3512      7.345023e-05  7.705356e-05  8.083851e-05  8.481464e-05
## ASV2411      1.665341e-04  1.744176e-04  1.826715e-04  1.913126e-04
## ASV2291     -4.203247e-05 -4.413135e-05 -4.633962e-05 -4.866341e-05
## ASV0807      1.967440e-04  2.063185e-04  2.163660e-04  2.269102e-04
## ASV1292      1.107270e-04  1.158116e-04  1.211210e-04  1.266642e-04
## ASV1035      5.061057e-05  5.278129e-05  5.503368e-05  5.736975e-05
## ASV0070     -1.165566e-04 -1.216507e-04 -1.269453e-04 -1.324462e-04
## ASV0255      4.610248e-05  4.818945e-05  5.036515e-05  5.263279e-05
## ASV0057     -5.026525e-04 -5.252773e-04 -5.488589e-04 -5.734320e-04
## ASV0077     -7.428684e-05 -7.744700e-05 -8.072308e-05 -8.411752e-05
## ASV0625      5.006500e-04  5.234006e-04  5.471334e-04  5.718863e-04
## ASV2464      2.424343e-04  2.533251e-04  2.646747e-04  2.764996e-04
## ASV1315      4.288698e-04  4.488689e-04  4.697833e-04  4.916537e-04
## ASV2673      3.168929e-04  3.319501e-04  3.477210e-04  3.642394e-04
## ASV2161      1.310463e-04  1.373207e-04  1.438971e-04  1.507901e-04
## ASV0337     -2.101342e-04 -2.198581e-04 -2.300189e-04 -2.406349e-04
## ASV7680     -2.467134e-04 -2.582505e-04 -2.703168e-04 -2.829353e-04
## ASV0611      5.355219e-04  5.607112e-04  5.870702e-04  6.146520e-04
## ASV3118     -1.825207e-04 -1.911171e-04 -2.001134e-04 -2.095275e-04
## ASV1284      1.981959e-04  2.077333e-04  2.177289e-04  2.282043e-04
## ASV0889      1.458600e-04  1.525449e-04  1.595247e-04  1.668114e-04
## ASV4649     -1.534743e-04 -1.606375e-04 -1.681278e-04 -1.759595e-04
## ASV1108     -1.956525e-04 -2.050061e-04 -2.148078e-04 -2.250793e-04
## ASV0738     -2.920203e-05 -2.992326e-05 -3.061798e-05 -3.127962e-05
## ASV0473      2.881435e-05  3.009979e-05  3.143843e-05  3.283209e-05
## ASV0598     -2.209226e-04 -2.307824e-04 -2.410511e-04 -2.517430e-04
## ASV0429      3.553501e-04  3.717852e-04  3.889566e-04  4.068950e-04
## ASV1549      3.530572e-04  3.698811e-04  3.875068e-04  4.059725e-04
## ASV1203      2.657142e-04  2.779207e-04  2.906667e-04  3.039743e-04
## ASV4532      1.075027e-05  1.110979e-05  1.147323e-05  1.183973e-05
## ASV0274     -2.668738e-04 -2.787949e-04 -2.912130e-04 -3.041459e-04
## ASV0163     -3.839117e-04 -4.011269e-04 -4.190639e-04 -4.377486e-04
## ASV1298      1.557033e-04  1.626657e-04  1.699185e-04  1.774717e-04
## ASV9424     -3.273435e-04 -3.427276e-04 -3.588246e-04 -3.756667e-04
## ASV0412      5.024848e-04  5.256197e-04  5.497828e-04  5.750165e-04
## ASV0284      2.245890e-04  2.346928e-04  2.452237e-04  2.561971e-04
## ASV0620     -1.694342e-04 -1.776121e-04 -1.861886e-04 -1.951832e-04
## ASV0153     -3.495015e-04 -3.660156e-04 -3.833038e-04 -4.014017e-04
## ASV0498      3.858000e-05  4.085241e-05  4.327063e-05  4.584461e-05
## ASV0097      2.481240e-04  2.598072e-04  2.720352e-04  2.848330e-04
## ASV0104     -1.155274e-03 -1.208716e-03 -1.264558e-03 -1.322901e-03
## ASV1282      2.051143e-04  2.148684e-04  2.250821e-04  2.357765e-04
## ASV3883     -1.167967e-04 -1.223575e-04 -1.281822e-04 -1.342831e-04
## ASV0801      1.173972e-04  1.231460e-04  1.291820e-04  1.355198e-04
## ASV1611     -4.447355e-04 -4.655363e-04 -4.872917e-04 -5.100441e-04
## ASV0227     -1.601238e-04 -1.678335e-04 -1.759173e-04 -1.843934e-04
## ASV0833      1.731984e-04  1.815824e-04  1.903771e-04  1.996029e-04
## ASV0718      4.143218e-04  4.335883e-04  4.537290e-04  4.747817e-04
## ASV1139      1.523702e-04  1.590948e-04  1.660902e-04  1.733648e-04
## ASV0766     -1.142300e-04 -1.194810e-04 -1.249645e-04 -1.306898e-04
## ASV2091      5.530484e-04  5.779685e-04  6.039471e-04  6.310236e-04
## ASV1238     -2.740253e-05 -2.803211e-05 -2.863519e-05 -2.920621e-05
## ASV9193     -5.914853e-05 -6.254751e-05 -6.615508e-05 -6.998444e-05
## ASV0290     -4.421528e-05 -4.635573e-05 -4.860065e-05 -5.095515e-05
## ASV0231      4.396019e-04  4.598989e-04  4.811035e-04  5.032534e-04
## ASV0185      7.902620e-05  8.366390e-05  8.860075e-05  9.385769e-05
## ASV2330      1.274470e-04  1.332636e-04  1.393339e-04  1.456678e-04
## ASV3119     -1.446611e-04 -1.517929e-04 -1.592859e-04 -1.671591e-04
## ASV2368     -2.007873e-04 -2.103334e-04 -2.203323e-04 -2.308054e-04
## ASV0122     -1.580744e-04 -1.651892e-04 -1.726058e-04 -1.803354e-04
## ASV1044      2.759236e-04  2.892288e-04  3.031820e-04  3.178151e-04
## ASV0160     -3.894723e-04 -4.068553e-04 -4.249604e-04 -4.438127e-04
## ASV0326      2.526350e-04  2.644079e-04  2.767174e-04  2.895870e-04
## ASV1388      4.420739e-04  4.625359e-04  4.839173e-04  5.062568e-04
## ASV0792      5.022010e-04  5.252627e-04  5.493433e-04  5.744838e-04
## ASV0036     -3.164154e-04 -3.313090e-04 -3.468954e-04 -3.632059e-04
## ASV2125      5.164732e-04  5.403467e-04  5.652901e-04  5.913484e-04
## ASV1075      9.897080e-05  1.037025e-04  1.086616e-04  1.138590e-04
## ASV0390      9.709891e-05  1.019432e-04  1.070385e-04  1.123985e-04
## ASV3790     -4.136612e-04 -4.329314e-04 -4.530800e-04 -4.741454e-04
## ASV1535     -3.774078e-05 -3.978789e-05 -4.195359e-05 -4.424514e-05
## ASV0263      8.581645e-05  8.981703e-05  9.399971e-05  9.837234e-05
## ASV0675      6.842002e-04  7.166609e-04  7.506530e-04  7.862478e-04
## ASV3348      6.594813e-05  6.919373e-05  7.260389e-05  7.618737e-05
## ASV0058     -6.482730e-04 -6.780151e-04 -7.090705e-04 -7.414926e-04
## ASV4142      1.641856e-04  1.717734e-04  1.797007e-04  1.879817e-04
## ASV0059     -5.584495e-04 -5.839975e-04 -6.106668e-04 -6.385023e-04
## ASV0013     -1.173316e-03 -1.227611e-03 -1.284346e-03 -1.343626e-03
## ASV0033     -3.447679e-04 -3.610357e-04 -3.780637e-04 -3.958870e-04
## ASV4354     -1.516048e-04 -1.585515e-04 -1.658042e-04 -1.733753e-04
## ASV0022     -3.641901e-04 -3.813675e-04 -3.993471e-04 -4.181656e-04
## ASV0134     -9.056557e-05 -9.499644e-05 -9.964882e-05 -1.045341e-04
## ASV0415     -7.393529e-05 -7.687725e-05 -7.990818e-05 -8.302804e-05
## ASV10103    -2.535402e-04 -2.653559e-04 -2.777096e-04 -2.906247e-04
## ASV1613      4.124328e-04  4.313586e-04  4.511195e-04  4.717492e-04
## ASV0135     -2.390328e-05 -2.460671e-05 -2.530315e-05 -2.598859e-05
## ASV0469     -5.148187e-04 -5.383932e-04 -5.630036e-04 -5.886914e-04
## ASV0471      3.340858e-04  3.499886e-04  3.666435e-04  3.840852e-04
## ASV0451     -8.853967e-05 -9.285437e-05 -9.738368e-05 -1.021387e-04
## ASV0747      1.286070e-04  1.349184e-04  1.415455e-04  1.485044e-04
## ASV1314     -1.938891e-04 -2.032069e-04 -2.129758e-04 -2.232178e-04
## ASV0425     -5.825594e-04 -6.088849e-04 -6.363355e-04 -6.649537e-04
## ASV0559     -3.325634e-04 -3.476172e-04 -3.633168e-04 -3.796870e-04
## ASV0148     -3.581581e-04 -3.742096e-04 -3.909343e-04 -4.083560e-04
## ASV0129     -1.760929e-04 -1.836211e-04 -1.914314e-04 -1.995310e-04
## ASV1072      1.710052e-04  1.785013e-04  1.862976e-04  1.944035e-04
## ASV2390      1.261461e-04  1.318702e-04  1.378407e-04  1.440669e-04
## ASV0548      3.749414e-04  3.924238e-04  4.107051e-04  4.298202e-04
## ASV0168     -5.648114e-04 -5.906491e-04 -6.176209e-04 -6.457723e-04
## ASV0066     -4.220497e-04 -4.416046e-04 -4.620402e-04 -4.833939e-04
## ASV0468     -1.547740e-04 -1.619421e-04 -1.694325e-04 -1.772587e-04
## ASV0172     -8.696700e-05 -9.044879e-05 -9.403784e-05 -9.773432e-05
## ASV0236     -2.158635e-04 -2.250661e-04 -2.346106e-04 -2.445051e-04
## ASV0250      1.343307e-05  1.494246e-05  1.660055e-05  1.842088e-05
## ASV0338     -2.832267e-05 -2.908200e-05 -2.982569e-05 -3.054872e-05
## ASV0450     -2.716707e-06 -2.871565e-06 -3.036206e-06 -3.211321e-06
## ASV0377      4.619295e-04  4.833728e-04  5.057857e-04  5.292096e-04
## ASV1022      1.288476e-04  1.348826e-04  1.411958e-04  1.477994e-04
## ASV6174     -3.169725e-05 -3.311884e-05 -3.460025e-05 -3.614366e-05
## ASV0786      5.159757e-05  5.385944e-05  5.621113e-05  5.865532e-05
## ASV0053     -5.577093e-04 -5.837550e-04 -6.109928e-04 -6.394748e-04
## ASV0697     -1.616248e-04 -1.688770e-04 -1.764344e-04 -1.843081e-04
## ASV0785      4.108548e-04  4.298398e-04  4.496774e-04  4.704039e-04
## ASV1967     -2.736758e-04 -2.860519e-04 -2.989574e-04 -3.124125e-04
## ASV0385     -1.250149e-04 -1.304492e-04 -1.360973e-04 -1.419659e-04
## ASV0295      5.628793e-08  4.352495e-07  8.667771e-07  1.356435e-06
## ASV0072     -4.415841e-04 -4.615553e-04 -4.823822e-04 -5.040972e-04
## ASV0157     -1.845139e-04 -1.926972e-04 -2.012141e-04 -2.100753e-04
## ASV0501      2.054310e-04  2.153987e-04  2.258535e-04  2.368193e-04
## ASV10729    -3.392764e-04 -3.551976e-04 -3.718545e-04 -3.892798e-04
## ASV1470      1.506328e-04  1.570424e-04  1.636912e-04  1.705851e-04
## ASV0050     -1.106477e-03 -1.157381e-03 -1.210546e-03 -1.266065e-03
## ASV0411     -2.804114e-05 -2.913116e-05 -3.025247e-05 -3.140496e-05
## ASV0549      2.087340e-04  2.186376e-04  2.290109e-04  2.398763e-04
## ASV0184      1.300166e-04  1.360721e-04  1.424037e-04  1.490232e-04
## ASV0705      1.575233e-04  1.650494e-04  1.729352e-04  1.811980e-04
## ASV1715      3.929897e-04  4.112831e-04  4.304086e-04  4.504022e-04
## ASV0603      4.716557e-05  4.944537e-05  5.183695e-05  5.434593e-05
## ASV0826      1.302681e-04  1.360702e-04  1.421120e-04  1.484018e-04
## ASV0034     -5.008993e-04 -5.238014e-04 -5.477057e-04 -5.726521e-04
## ASV0838      1.083754e-04  1.134770e-04  1.188149e-04  1.243994e-04
## ASV0614     -2.856265e-04 -2.987747e-04 -3.125072e-04 -3.268480e-04
## ASV0014     -1.074081e-03 -1.123608e-03 -1.175346e-03 -1.229385e-03
## ASV0585     -6.355091e-05 -6.636167e-05 -6.928736e-05 -7.233186e-05
## ASV0016     -1.098031e-03 -1.148685e-03 -1.201602e-03 -1.256875e-03
## ASV5394     -2.790723e-04 -2.921273e-04 -3.057817e-04 -3.200619e-04
## ASV0666      2.366102e-04  2.475028e-04  2.588793e-04  2.707594e-04
## ASV2085      9.352950e-05  9.738509e-05  1.013701e-04  1.054859e-04
## ASV0003     -1.004349e-03 -1.050587e-03 -1.098882e-03 -1.149319e-03
## ASV0346     -1.853360e-05 -1.886995e-05 -1.917338e-05 -1.943816e-05
## ASV0267     -1.618098e-04 -1.691303e-04 -1.767629e-04 -1.847188e-04
## ASV0353      2.207326e-04  2.317516e-04  2.433374e-04  2.555202e-04
## ASV2419      2.831890e-04  2.961404e-04  3.096593e-04  3.237685e-04
## ASV0447      1.334740e-04  1.401662e-04  1.472067e-04  1.546147e-04
## ASV0654      4.393501e-04  4.599719e-04  4.815467e-04  5.041172e-04
## ASV0151      6.718589e-05  7.059784e-05  7.419216e-05  7.797935e-05
## ASV0065     -4.022053e-04 -4.206282e-04 -4.398621e-04 -4.599396e-04
## ASV0527      2.941354e-04  3.077668e-04  3.220125e-04  3.368986e-04
## ASV4055     -1.110764e-04 -1.164567e-04 -1.221016e-04 -1.280243e-04
## ASV0166     -3.300523e-04 -3.446704e-04 -3.598869e-04 -3.757219e-04
## ASV0417     -2.852992e-04 -2.983710e-04 -3.120178e-04 -3.262627e-04
## ASV0078     -2.259133e-04 -2.360150e-04 -2.465385e-04 -2.574988e-04
## ASV0322     -2.716433e-04 -2.836451e-04 -2.961362e-04 -3.091330e-04
## ASV0156     -3.542653e-04 -3.701302e-04 -3.866616e-04 -4.038836e-04
## ASV0648     -3.276872e-04 -3.431339e-04 -3.593010e-04 -3.762213e-04
## ASV0407      2.205543e-05  2.308788e-05  2.416970e-05  2.530350e-05
## ASV2030     -7.037577e-05 -7.347038e-05 -7.668972e-05 -8.003786e-05
## ASV0300      1.951717e-04  2.047822e-04  2.148763e-04  2.254789e-04
## ASV1150     -2.551807e-05 -2.659532e-05 -2.771102e-05 -2.886584e-05
## ASV0958      1.989439e-04  2.085373e-04  2.185985e-04  2.291506e-04
## ASV0216     -3.448560e-04 -3.604889e-04 -3.767941e-04 -3.937974e-04
## ASV0446      4.815067e-04  5.045502e-04  5.286984e-04  5.540040e-04
## ASV0367     -1.648847e-04 -1.725326e-04 -1.805259e-04 -1.888795e-04
## ASV0200     -3.029730e-04 -3.169257e-04 -3.315003e-04 -3.467228e-04
## ASV0334     -1.576169e-04 -1.642987e-04 -1.712237e-04 -1.783968e-04
## ASV1311      2.172623e-04  2.273122e-04  2.378133e-04  2.487844e-04
## ASV0458      2.322672e-04  2.429332e-04  2.540708e-04  2.656992e-04
## ASV1371      6.993927e-06  7.336552e-06  7.696342e-06  8.074183e-06
## ASV0418      2.757572e-04  2.881639e-04  3.010970e-04  3.145759e-04
## ASV0004      3.353354e-04  3.507434e-04  3.668332e-04  3.836328e-04
## ASV1943      2.460553e-04  2.572487e-04  2.689277e-04  2.811113e-04
## ASV1495     -6.340903e-05 -6.680277e-05 -7.039181e-05 -7.418835e-05
## ASV0901     -3.848147e-04 -4.029643e-04 -4.219616e-04 -4.418456e-04
## ASV0628      2.254910e-04  2.357959e-04  2.465511e-04  2.577744e-04
## ASV0400      9.251047e-05  9.684057e-05  1.013686e-04  1.061030e-04
## ASV0116     -2.919649e-04 -3.056771e-04 -3.200245e-04 -3.350359e-04
## ASV0788      2.437766e-04  2.550990e-04  2.669337e-04  2.793029e-04
## ASV0117      1.562756e-04  1.637709e-04  1.716280e-04  1.798647e-04
## ASV3137      4.417218e-05  4.624509e-05  4.841413e-05  5.068367e-05
## ASV0001      4.044743e-04  4.227732e-04  4.418565e-04  4.617542e-04
## ASV1651      2.668378e-04  2.787628e-04  2.911851e-04  3.041223e-04
## ASV1692      2.878873e-04  3.015509e-04  3.158603e-04  3.308456e-04
## ASV0660      1.665607e-04  1.739942e-04  1.817344e-04  1.897913e-04
## ASV0508      1.961433e-05  2.035776e-05  2.111979e-05  2.189993e-05
## ASV1660     -1.186085e-04 -1.243380e-04 -1.303468e-04 -1.366490e-04
## ASV0233      6.385342e-05  6.684843e-05  6.998226e-05  7.326125e-05
## ASV1343     -2.912037e-04 -3.048592e-04 -3.191451e-04 -3.340895e-04
## ASV0209      2.710086e-04  2.833230e-04  2.961698e-04  3.095696e-04
## ASV0193     -3.413522e-04 -3.565181e-04 -3.723099e-04 -3.887493e-04
## ASV0357     -2.292203e-05 -2.380439e-05 -2.470942e-05 -2.563647e-05
## ASV0198      7.756896e-05  8.132730e-05  8.526920e-05  8.940361e-05
## ASV0007      3.834167e-04  4.007620e-04  4.188511e-04  4.377120e-04
## ASV1772     -3.848499e-05 -4.019974e-05 -4.198492e-05 -4.384284e-05
## ASV0009      3.616759e-04  3.780107e-04  3.950433e-04  4.128001e-04
## ASV0006      1.466216e-04  1.530352e-04  1.597035e-04  1.666343e-04
## ASV0011     -4.063219e-04 -4.254154e-04 -4.453932e-04 -4.662950e-04
## ASV0015      2.816363e-04  2.945825e-04  3.081020e-04  3.222181e-04
## ASV0017      2.982339e-04  3.119215e-04  3.262134e-04  3.411339e-04
## ASV0235     -2.389714e-04 -2.502616e-04 -2.620794e-04 -2.744487e-04
## ASV0382      4.432835e-05  4.689419e-05  4.962141e-05  5.252085e-05
## ASV2357      3.611452e-04  3.780348e-04  3.957000e-04  4.141750e-04
## ASV0567     -2.602371e-04 -2.721139e-04 -2.845101e-04 -2.974464e-04
## ASV0165      2.896981e-04  3.032812e-04  3.174907e-04  3.323546e-04
## ASV0005      5.760619e-04  6.024855e-04  6.300754e-04  6.588787e-04
## ASV0384     -2.674270e-05 -2.769698e-05 -2.866689e-05 -2.965045e-05
## ASV0002      1.213865e-04  1.271166e-04  1.331143e-04  1.393918e-04
## ASV3017      3.365721e-04  3.519390e-04  3.679772e-04  3.847132e-04
## ASV0091      1.294784e-04  1.356127e-04  1.420358e-04  1.487614e-04
## ASV0186     -3.470826e-04 -3.632954e-04 -3.802505e-04 -3.979805e-04
## ASV0370      3.747588e-05  3.939061e-05  4.140849e-05  4.353550e-05
## ASV0018      5.999456e-04  6.275114e-04  6.562983e-04  6.863562e-04
## ASV1377      5.250424e-04  5.491451e-04  5.743117e-04  6.005852e-04
## ASV0019      6.008174e-04  6.284330e-04  6.572727e-04  6.873868e-04
## ASV0023      4.271075e-05  4.431962e-05  4.596762e-05  4.765349e-05
## ASV2194      1.898774e-04  1.985755e-04  2.076586e-04  2.171427e-04
## ASV1155     -2.286679e-05 -2.377026e-05 -2.469961e-05 -2.565450e-05
## ASV0510     -2.179602e-04 -2.274517e-04 -2.373168e-04 -2.475665e-04
## ASV2371     -2.151475e-04 -2.247006e-04 -2.346459e-04 -2.449967e-04
## ASV0024      1.378647e-05  1.404836e-05  1.428808e-05  1.450171e-05
## ASV2452      2.816941e-04  2.944169e-04  3.076829e-04  3.215123e-04
## ASV2332      9.543943e-06  1.019290e-05  1.089221e-05  1.164620e-05
## ASV2591      1.360287e-05  1.467179e-05  1.582886e-05  1.708137e-05
## ASV0521      3.881326e-04  4.065727e-04  4.258850e-04  4.461101e-04
## ASV5542      1.201647e-04  1.259760e-04  1.320709e-04  1.384634e-04
## ASV0336     -1.737516e-04 -1.814528e-04 -1.894711e-04 -1.978174e-04
## ASV10102     2.693555e-04  2.820766e-04  2.953930e-04  3.093319e-04
## ASV16823    -2.094606e-04 -2.187572e-04 -2.284353e-04 -2.385079e-04
## ASV3104      2.094441e-04  2.187391e-04  2.284156e-04  2.384864e-04
## ASV0781      1.035683e-04  1.084138e-04  1.134817e-04  1.187819e-04
## ASV10899     9.833959e-05  1.032938e-04  1.085077e-04  1.139959e-04
## ASV11222    -2.094332e-04 -2.187273e-04 -2.284028e-04 -2.384726e-04
## ASV11327    -2.094167e-04 -2.187093e-04 -2.283832e-04 -2.384511e-04
## ASV12458    -2.094001e-04 -2.186913e-04 -2.283635e-04 -2.384297e-04
## ASV1636     -1.715217e-04 -1.791285e-04 -1.870468e-04 -1.952870e-04
## ASV1890     -2.088203e-04 -2.181696e-04 -2.279107e-04 -2.380575e-04
## ASV2898      4.538886e-04  4.747290e-04  4.964900e-04  5.192089e-04
## ASV8328     -3.390433e-05 -3.496491e-05 -3.602622e-05 -3.708402e-05
## ASV0709     -3.713160e-04 -3.884290e-04 -4.063038e-04 -4.249717e-04
## ASV0856      5.985073e-05  6.281743e-05  6.593568e-05  6.921355e-05
## ASV0909     -1.560892e-04 -1.627731e-04 -1.697073e-04 -1.768978e-04
## ASV0937     -2.881740e-04 -3.015570e-04 -3.155462e-04 -3.301680e-04
## ASV11390    -2.093650e-04 -2.186530e-04 -2.283219e-04 -2.383844e-04
## ASV11966     1.079158e-04  1.131974e-04  1.187427e-04  1.245652e-04
## ASV12990     5.855754e-05  6.138054e-05  6.434025e-05  6.744324e-05
## ASV14797     2.192632e-04  2.292996e-04  2.397762e-04  2.507106e-04
## ASV14904    -2.093608e-04 -2.186485e-04 -2.283170e-04 -2.383792e-04
## ASV15304     5.753770e-05  6.053625e-05  6.370027e-05  6.703949e-05
## ASV16696    -2.093473e-04 -2.186339e-04 -2.283011e-04 -2.383619e-04
## ASV1690      1.093821e-04  1.147982e-04  1.204898e-04  1.264712e-04
## ASV2029      5.816804e-04  6.084659e-04  6.364419e-04  6.656575e-04
## ASV2834      3.117816e-04  3.262790e-04  3.414343e-04  3.572759e-04
## ASV4003      9.027154e-05  9.491881e-05  9.981828e-05  1.049845e-04
## ASV4064      2.157720e-04  2.258250e-04  2.363355e-04  2.473235e-04
## ASV4294      7.736269e-05  8.135593e-05  8.556719e-05  9.000924e-05
## ASV4609     -8.774242e-06 -9.078233e-06 -9.386661e-06 -9.698905e-06
## ASV6283     -2.093454e-04 -2.186319e-04 -2.282993e-04 -2.383601e-04
## ASV6491     -2.093289e-04 -2.186139e-04 -2.282796e-04 -2.383387e-04
## ASV7453      8.401295e-05  8.827815e-05  9.276944e-05  9.749946e-05
## ASV7959      1.724407e-05  1.840748e-05  1.965651e-05  2.099773e-05
## ASV8219      2.093175e-04  2.186017e-04  2.282663e-04  2.383244e-04
## ASV8547     -2.093010e-04 -2.185836e-04 -2.282467e-04 -2.383030e-04
## ASV9319      1.435964e-04  1.504605e-04  1.576530e-04  1.651895e-04
## ASV9382     -2.092911e-04 -2.185729e-04 -2.282350e-04 -2.382903e-04
## ASV11516    -2.092746e-04 -2.185549e-04 -2.282154e-04 -2.382689e-04
## ASV14377    -2.092581e-04 -2.185369e-04 -2.281958e-04 -2.382475e-04
## ASV1867      3.088364e-04  3.233521e-04  3.385409e-04  3.544330e-04
## ASV1895     -7.107359e-05 -7.418378e-05 -7.741782e-05 -8.077959e-05
## ASV3168      1.324770e-04  1.385880e-04  1.449708e-04  1.516363e-04
## ASV4449      2.609856e-04  2.727342e-04  2.849809e-04  2.977443e-04
## ASV6596      1.518566e-04  1.593127e-04  1.671439e-04  1.753699e-04
## ASV7492     -7.745410e-05 -8.058898e-05 -8.382372e-05 -8.715890e-05
## ASV9854     -1.069092e-04 -1.115391e-04 -1.163485e-04 -1.213423e-04
## ASV6296      2.092237e-04  2.184995e-04  2.281552e-04  2.382035e-04
## ASV4201      7.019552e-05  7.397903e-05  7.798181e-05  8.221754e-05
## ASV0552      5.187661e-04  5.432609e-04  5.689008e-04  5.957383e-04
## ASV3671     -4.181327e-05 -4.337982e-05 -4.498332e-05 -4.662239e-05
## ASV3529     -4.513468e-05 -4.678134e-05 -4.846192e-05 -5.017430e-05
## ASV1060      1.290183e-04  1.350564e-04  1.413723e-04  1.479783e-04
## ASV0239     -2.933380e-04 -3.064881e-04 -3.201887e-04 -3.344589e-04
## ASV5711     -2.693415e-04 -2.814687e-04 -2.941104e-04 -3.072857e-04
## ASV4152     -3.548837e-04 -3.710442e-04 -3.879068e-04 -4.054990e-04
## ASV1461      3.194004e-04  3.338667e-04  3.489530e-04  3.646829e-04
## ASV2877      2.588612e-04  2.707335e-04  2.831286e-04  2.960675e-04
## ASV0012      1.932217e-04  2.023405e-04  2.118850e-04  2.218745e-04
## ASV9823      6.191567e-05  6.428754e-05  6.672455e-05  6.922625e-05
## ASV0008      2.111068e-04  2.210145e-04  2.313798e-04  2.422232e-04
## ASV7832     -2.195039e-04 -2.294789e-04 -2.398858e-04 -2.507415e-04
## ASV1915      1.836147e-05  1.943581e-05  2.057860e-05  2.179449e-05
## ASV0055      1.499791e-04  1.568500e-04  1.640224e-04  1.715083e-04
## ASV0032      3.677777e-04  3.846495e-04  4.022658e-04  4.206568e-04
## ASV2977     -2.980502e-04 -3.115763e-04 -3.256855e-04 -3.404002e-04
## ASV0466      3.024082e-04  3.159833e-04  3.301295e-04  3.448673e-04
## ASV3866      3.213310e-04  3.363820e-04  3.521257e-04  3.685929e-04
## ASV0040      4.250184e-04  4.449431e-04  4.657864e-04  4.875889e-04
## ASV0496     -2.447147e-05 -2.601954e-05 -2.767609e-05 -2.944931e-05
## ASV0052      5.212068e-04  5.452846e-04  5.704401e-04  5.967183e-04
## ASV3828     -3.198214e-04 -3.344224e-04 -3.496619e-04 -3.655654e-04
## ASV1930      2.014722e-04  2.109309e-04  2.208263e-04  2.311776e-04
## ASV2126      3.246181e-04  3.396179e-04  3.552890e-04  3.716595e-04
## ASV0793      1.935892e-04  2.028629e-04  2.125821e-04  2.227683e-04
## ASV0299     -1.378258e-04 -1.439255e-04 -1.502730e-04 -1.568765e-04
## ASV0208      3.060783e-04  3.207345e-04  3.360941e-04  3.521908e-04
## ASV0511     -1.661477e-04 -1.734623e-04 -1.810704e-04 -1.889812e-04
## ASV1123     -2.168940e-04 -2.265708e-04 -2.366489e-04 -2.471424e-04
## ASV0099     -1.159698e-04 -1.211101e-04 -1.264607e-04 -1.320285e-04
## ASV0752     -2.598092e-05 -2.743228e-05 -2.897158e-05 -3.060457e-05
## ASV0883      3.291412e-06  3.557091e-06  3.845053e-06  4.157161e-06
## ASV0683      2.713568e-04  2.842488e-04  2.977509e-04  3.118919e-04
## ASV4117     -3.207340e-04 -3.353401e-04 -3.505811e-04 -3.664820e-04
## ASV2172      1.204439e-04  1.260668e-04  1.319468e-04  1.380950e-04
## ASV0330     -2.152959e-04 -2.252079e-04 -2.355618e-04 -2.463762e-04
## ASV0728      2.061380e-04  2.158814e-04  2.260807e-04  2.367569e-04
## ASV0499      4.096319e-04  4.290948e-04  4.494801e-04  4.708314e-04
## ASV0120     -4.537449e-04 -4.747885e-04 -4.967808e-04 -5.197621e-04
## ASV1446      3.693618e-05  3.834079e-05  3.978022e-05  4.125333e-05
## ASV17171    -3.049209e-04 -3.188594e-04 -3.334088e-04 -3.485935e-04
## ASV0533      8.749309e-05  9.171804e-05  9.614942e-05  1.007975e-04
## ASV2495     -1.241050e-04 -1.299537e-04 -1.360761e-04 -1.424850e-04
## ASV5582      1.075646e-04  1.122917e-04  1.172080e-04  1.223190e-04
## ASV1488      1.090194e-04  1.146449e-04  1.205717e-04  1.268164e-04
## ASV0682      2.867088e-04  3.003981e-04  3.147423e-04  3.297728e-04
## ASV0068     -1.521690e-05 -1.610357e-05 -1.704640e-05 -1.804917e-05
## ASV1987     -1.553509e-04 -1.629737e-04 -1.709794e-04 -1.793877e-04
## ASV0035      5.554093e-05  5.776374e-05  6.005335e-05  6.240942e-05
## ASV7192     -2.052179e-04 -2.144027e-04 -2.239714e-04 -2.339377e-04
## ASV0873      3.039880e-05  3.155872e-05  3.274851e-05  3.396749e-05
## ASV4749      1.806326e-05  1.850700e-05  1.893366e-05  1.933901e-05
## ASV2174      1.875101e-04  1.955189e-04  2.038304e-04  2.124529e-04
## ASV1476     -1.682889e-04 -1.760268e-04 -1.841085e-04 -1.925484e-04
## ASV0740     -4.138685e-04 -4.334247e-04 -4.538972e-04 -4.753279e-04
## ASV0170      8.742179e-05  9.145033e-05  9.565867e-05  1.000543e-04
## ASV2466     -3.754847e-04 -3.928199e-04 -4.109312e-04 -4.298510e-04
## ASV1709      2.904506e-04  3.037158e-04  3.175609e-04  3.320089e-04
## ASV6170     -2.446734e-04 -2.551183e-04 -2.659607e-04 -2.772121e-04
## ASV3673      2.921362e-04  3.051819e-04  3.187757e-04  3.329381e-04
## ASV1745      1.488395e-05  1.522951e-05  1.556287e-05  1.588148e-05
## ASV0380     -1.926608e-04 -2.006121e-04 -2.088408e-04 -2.173527e-04
## ASV0426     -6.122734e-05 -6.378242e-05 -6.642866e-05 -6.916801e-05
## ASV0202     -6.312344e-05 -6.542429e-05 -6.777055e-05 -7.015878e-05
## ASV6350     -2.434814e-04 -2.538815e-04 -2.646781e-04 -2.758829e-04
## ASV0713     -1.809514e-04 -1.893799e-04 -1.981927e-04 -2.074066e-04
## ASV1822      3.910819e-05  4.121370e-05  4.343870e-05  4.579019e-05
## ASV4569      2.864844e-04  2.994710e-04  3.130195e-04  3.271520e-04
## ASV0030     -6.591287e-05 -6.922060e-05 -7.269867e-05 -7.635600e-05
## ASV0331      1.184964e-04  1.243158e-04  1.304275e-04  1.368466e-04
## ASV2981      2.939739e-04  3.079907e-04  3.226731e-04  3.380519e-04
## ASV0828     -1.959753e-04 -2.054308e-04 -2.153455e-04 -2.257419e-04
## ASV2440      4.609583e-04  4.827580e-04  5.055796e-04  5.294698e-04
## ASV3006     -1.957002e-04 -2.038088e-04 -2.122037e-04 -2.208912e-04
## ASV3875     -1.956859e-04 -2.037932e-04 -2.121869e-04 -2.208730e-04
## ASV4511      1.148056e-04  1.203130e-04  1.260861e-04  1.321378e-04
## ASV4700     -1.956716e-04 -2.037778e-04 -2.121702e-04 -2.208550e-04
## ASV5804     -1.956573e-04 -2.037623e-04 -2.121534e-04 -2.208367e-04
## ASV6826      2.126421e-04  2.227771e-04  2.333945e-04  2.445174e-04
## ASV7280      1.840225e-04  1.930829e-04  2.025964e-04  2.125859e-04
## ASV7535     -1.956506e-04 -2.037552e-04 -2.121458e-04 -2.208287e-04
## ASV0651     -2.072754e-04 -2.166171e-04 -2.263543e-04 -2.365011e-04
## ASV0913      2.776133e-04  2.907314e-04  3.044645e-04  3.188409e-04
## ASV10832    -1.956370e-04 -2.037404e-04 -2.121298e-04 -2.208114e-04
## ASV1117     -3.960706e-04 -4.140814e-04 -4.328758e-04 -4.524849e-04
## ASV11329     9.956701e-05  1.049542e-04  1.106515e-04  1.166776e-04
## ASV13209    -7.835727e-06 -7.422034e-06 -6.925831e-06 -6.338832e-06
## ASV1345      5.495850e-05  5.790718e-05  6.102096e-05  6.430913e-05
## ASV1719     -1.956155e-04 -2.037172e-04 -2.121049e-04 -2.207845e-04
## ASV1886      2.256967e-04  2.358670e-04  2.464730e-04  2.575316e-04
## ASV2158     -4.814377e-05 -4.955379e-05 -5.096013e-05 -5.235763e-05
## ASV2189      2.437055e-04  2.549619e-04  2.667234e-04  2.790115e-04
## ASV2257      1.807336e-04  1.889234e-04  1.974686e-04  2.063837e-04
## ASV2283      1.955841e-04  2.036832e-04  2.120679e-04  2.207445e-04
## ASV2328      1.955698e-04  2.036677e-04  2.120511e-04  2.207263e-04
## ASV2434     -2.933502e-04 -3.063616e-04 -3.199132e-04 -3.340246e-04
## ASV2648      1.955382e-04  2.036334e-04  2.120139e-04  2.206859e-04
## ASV2698      2.863036e-04  2.996533e-04  3.136138e-04  3.282122e-04
## ASV2775      3.438175e-04  3.590215e-04  3.748476e-04  3.913169e-04
## ASV3171      1.955080e-04  2.036005e-04  2.119781e-04  2.206470e-04
## ASV3227      2.550111e-04  2.662197e-04  2.778799e-04  2.900066e-04
## ASV3397      2.126030e-05  2.257145e-05  2.396740e-05  2.545350e-05
## ASV3444      2.831051e-04  2.955159e-04  3.084289e-04  3.218616e-04
## ASV3556      1.954706e-04  2.035599e-04  2.119341e-04  2.205993e-04
## ASV3606     -1.954563e-04 -2.035444e-04 -2.119173e-04 -2.205811e-04
## ASV4190      2.531340e-04  2.649053e-04  2.772130e-04  2.900807e-04
## ASV4197      2.925069e-04  3.053998e-04  3.188187e-04  3.327820e-04
## ASV4722      2.636456e-04  2.757031e-04  2.882915e-04  3.014325e-04
## ASV4765      6.951105e-05  7.301936e-05  7.670710e-05  8.058318e-05
## ASV4809      1.954204e-04  2.035054e-04  2.118749e-04  2.205350e-04
## ASV4846      1.884576e-04  1.973492e-04  2.066542e-04  2.163909e-04
## ASV4903     -4.815283e-05 -4.957701e-05 -5.099929e-05 -5.241469e-05
## ASV4944     -1.954066e-04 -2.034906e-04 -2.118590e-04 -2.205179e-04
## ASV5151     -7.987801e-05 -8.431895e-05 -8.902332e-05 -9.400739e-05
## ASV5413     -1.953965e-04 -2.034797e-04 -2.118473e-04 -2.205055e-04
## ASV5537     -1.953822e-04 -2.034642e-04 -2.118306e-04 -2.204873e-04
## ASV5688      1.953679e-04  2.034487e-04  2.118138e-04  2.204692e-04
## ASV5752      1.004042e-04  1.055262e-04  1.109170e-04  1.165909e-04
## ASV6122     -1.953578e-04 -2.034379e-04 -2.118021e-04 -2.204566e-04
## ASV6135      1.953435e-04  2.034224e-04  2.117853e-04  2.204385e-04
## ASV6188     -1.953292e-04 -2.034069e-04 -2.117686e-04 -2.204203e-04
## ASV6216      2.920313e-04  3.048841e-04  3.182602e-04  3.321775e-04
## ASV6242      1.952987e-04  2.033737e-04  2.117325e-04  2.203812e-04
## ASV6383      1.952844e-04  2.033582e-04  2.117158e-04  2.203631e-04
## ASV6781      1.952701e-04  2.033428e-04  2.116990e-04  2.203449e-04
## ASV6799     -1.952558e-04 -2.033273e-04 -2.116823e-04 -2.203268e-04
## ASV7374     -1.952416e-04 -2.033118e-04 -2.116655e-04 -2.203087e-04
## ASV7539     -1.952273e-04 -2.032964e-04 -2.116488e-04 -2.202906e-04
## ASV8591     -1.952130e-04 -2.032809e-04 -2.116320e-04 -2.202724e-04
## ASV8637      1.951988e-04  2.032655e-04  2.116153e-04  2.202543e-04
## ASV12796    -1.951845e-04 -2.032500e-04 -2.115986e-04 -2.202362e-04
## ASV1934      2.290900e-04  2.397894e-04  2.509790e-04  2.626805e-04
## ASV22549     1.610077e-05  1.761721e-05  1.926577e-05  2.105687e-05
## ASV29857    -1.951712e-04 -2.032357e-04 -2.115831e-04 -2.202196e-04
## ASV3215      2.790963e-04  2.923076e-04  3.061410e-04  3.206256e-04
## ASV3236     -1.951559e-04 -2.032191e-04 -2.115652e-04 -2.202002e-04
## ASV3954     -1.951417e-04 -2.032037e-04 -2.115485e-04 -2.201821e-04
## ASV4850      1.951274e-04  2.031882e-04  2.115318e-04  2.201640e-04
## ASV5225      1.951131e-04  2.031728e-04  2.115150e-04  2.201459e-04
## ASV5532     -1.950989e-04 -2.031573e-04 -2.114983e-04 -2.201278e-04
## ASV7258      2.628837e-05  2.842884e-05  3.074438e-05  3.324875e-05
## ASV9474     -1.084877e-04 -1.125386e-04 -1.166914e-04 -1.209443e-04
## ASV11857    -1.950803e-04 -2.031374e-04 -2.114770e-04 -2.201050e-04
## ASV1202     -1.950661e-04 -2.031220e-04 -2.114603e-04 -2.200869e-04
## ASV14742     1.423964e-04  1.495944e-04  1.571691e-04  1.651410e-04
## ASV16652     7.484725e-05  7.867494e-05  8.270250e-05  8.694016e-05
## ASV2019      2.897278e-04  3.026315e-04  3.160737e-04  3.300741e-04
## ASV2410     -2.708037e-04 -2.832582e-04 -2.962687e-04 -3.098587e-04
## ASV2718      2.892604e-04  3.031557e-04  3.177193e-04  3.329832e-04
## ASV2738      3.270258e-04  3.414156e-04  3.563879e-04  3.719622e-04
## ASV2876      1.950346e-04  2.030879e-04  2.114234e-04  2.200470e-04
## ASV3177      1.950204e-04  2.030725e-04  2.114067e-04  2.200289e-04
## ASV4367      1.950061e-04  2.030571e-04  2.113900e-04  2.200108e-04
## ASV4635      7.098261e-05  7.509396e-05  7.945871e-05  8.409279e-05
## ASV4896      1.870251e-05  2.052609e-05  2.251364e-05  2.467871e-05
## ASV4907      1.490427e-04  1.567413e-04  1.648544e-04  1.734053e-04
## ASV5230     -1.950067e-04 -2.030581e-04 -2.113915e-04 -2.200131e-04
## ASV6509     -1.949925e-04 -2.030427e-04 -2.113748e-04 -2.199950e-04
## ASV7376     -1.949783e-04 -2.030272e-04 -2.113581e-04 -2.199769e-04
## ASV8163     -1.949640e-04 -2.030118e-04 -2.113414e-04 -2.199588e-04
## ASV8195     -1.949498e-04 -2.029964e-04 -2.113247e-04 -2.199408e-04
## ASV8923      1.237409e-04  1.299678e-04  1.365163e-04  1.434035e-04
## ASV9666     -1.722037e-04 -1.791764e-04 -1.863804e-04 -1.938194e-04
## ASV1482      1.840953e-04  1.929047e-04  2.021348e-04  2.118057e-04
## ASV2726      2.387706e-04  2.502668e-04  2.623179e-04  2.749505e-04
## ASV3281     -1.949352e-04 -2.029808e-04 -2.113080e-04 -2.199230e-04
## ASV4235     -1.949209e-04 -2.029654e-04 -2.112914e-04 -2.199049e-04
## ASV4808      2.937529e-04  3.067819e-04  3.203510e-04  3.344798e-04
## ASV4861     -2.929348e-04 -3.059099e-04 -3.194224e-04 -3.334918e-04
## ASV5276      2.904318e-04  3.032938e-04  3.166862e-04  3.306279e-04
## ASV5837      2.491975e-04  2.608861e-04  2.731164e-04  2.859128e-04
## ASV7098      2.545065e-04  2.663917e-04  2.788231e-04  2.918251e-04
## ASV8451     -1.948541e-04 -2.028925e-04 -2.112121e-04 -2.198186e-04
## ASV8694     -1.948398e-04 -2.028771e-04 -2.111954e-04 -2.198006e-04
## ASV0905     -1.073924e-04 -1.125370e-04 -1.179236e-04 -1.235625e-04
## ASV2900      2.399452e-04  2.501403e-04  2.607195e-04  2.716936e-04
## ASV3963     -1.892914e-04 -1.970657e-04 -2.051085e-04 -2.134253e-04
## ASV0041     -2.200469e-04 -2.306508e-04 -2.417678e-04 -2.534227e-04
## ASV1865      2.222337e-04  2.332838e-04  2.448966e-04  2.571012e-04
## ASV1140      1.820401e-04  1.908702e-04  2.001289e-04  2.098366e-04
## ASV1179      2.603624e-04  2.726688e-04  2.855509e-04  2.990351e-04
## ASV0279      3.650955e-04  3.817374e-04  3.991076e-04  4.172357e-04
## ASV0043     -3.240322e-05 -3.433262e-05 -3.638952e-05 -3.858319e-05
## ASV2097     -2.025073e-04 -2.113947e-04 -2.206434e-04 -2.302661e-04
## ASV0309     -1.020226e-04 -1.064879e-04 -1.111316e-04 -1.159592e-04
## ASV0607      4.446323e-04  4.655869e-04  4.875177e-04  5.104690e-04
## ASV0025     -4.706265e-04 -4.929342e-04 -5.162906e-04 -5.407440e-04
## ASV2284     -7.421111e-05 -7.700551e-05 -7.987132e-05 -8.280727e-05
## ASV0556      8.080972e-05  8.500740e-05  8.943414e-05  9.410302e-05
## ASV5040      1.626470e-04  1.691718e-04  1.759075e-04  1.828567e-04
## ASV2924     -1.744699e-04 -1.815707e-04 -1.889111e-04 -1.964951e-04
## ASV1331      5.706777e-04  5.970657e-04  6.246401e-04  6.534514e-04
## ASV0506     -2.594827e-04 -2.708887e-04 -2.827542e-04 -2.950940e-04
## ASV1514      4.283824e-04  4.482960e-04  4.691115e-04  4.908672e-04
## ASV2144      3.601663e-04  3.767562e-04  3.940863e-04  4.121876e-04
## ASV2265      4.783499e-04  5.005555e-04  5.237656e-04  5.480233e-04
## ASV5156      1.024556e-04  1.066248e-04  1.109330e-04  1.153823e-04
## ASV5534      8.247537e-05  8.563192e-05  8.887403e-05  9.220081e-05
## ASV5747     -1.666110e-05 -1.816269e-05 -1.979387e-05 -2.156504e-05
## ASV6657      2.155147e-04  2.251247e-04  2.351359e-04  2.455631e-04
## ASV0658     -2.424842e-04 -2.531310e-04 -2.642060e-04 -2.757233e-04
## ASV0716      6.160426e-05  6.434669e-05  6.720243e-05  7.017537e-05
## ASV1657      1.033604e-04  1.075173e-04  1.118074e-04  1.162323e-04
## ASV1885     -6.439246e-06 -7.410622e-06 -8.482890e-06 -9.664863e-06
## ASV2333      5.254914e-04  5.494782e-04  5.745142e-04  6.006412e-04
## ASV3375      1.939510e-04  2.024084e-04  2.112023e-04  2.203434e-04
## ASV4317      2.041014e-04  2.135793e-04  2.234888e-04  2.338488e-04
## ASV9599     -1.671720e-05 -1.822365e-05 -1.986008e-05 -2.163693e-05
## ASV0175     -7.067244e-04 -7.389745e-04 -7.726309e-04 -8.077488e-04
## ASV1032      2.085653e-04  2.176427e-04  2.270787e-04  2.368846e-04
## ASV1235      5.489731e-06  5.274454e-06  5.009024e-06  4.688030e-06
## ASV1262      6.222312e-04  6.507806e-04  6.805909e-04  7.117136e-04
## ASV1320      1.530162e-04  1.607066e-04  1.687970e-04  1.773088e-04
## ASV13797     2.293539e-04  2.396426e-04  2.503672e-04  2.615441e-04
## ASV1491      1.196324e-04  1.258218e-04  1.323446e-04  1.392192e-04
## ASV15014    -1.673983e-05 -1.824802e-05 -1.988631e-05 -2.166512e-05
## ASV1510      1.896637e-04  1.989522e-04  2.087009e-04  2.189325e-04
## ASV1551     -7.695319e-05 -8.041545e-05 -8.402457e-05 -8.778600e-05
## ASV1919     -1.113980e-05 -1.093105e-05 -1.065135e-05 -1.029280e-05
## ASV2114      1.126581e-04  1.174436e-04  1.224096e-04  1.275614e-04
## ASV21486    -1.673156e-05 -1.823864e-05 -1.987566e-05 -2.165304e-05
## ASV2448      3.177568e-04  3.320310e-04  3.469099e-04  3.624159e-04
## ASV2589      1.508463e-04  1.574131e-04  1.642403e-04  1.713361e-04
## ASV2608      2.532770e-04  2.647513e-04  2.767212e-04  2.892061e-04
## ASV2786      2.028231e-04  2.120886e-04  2.217627e-04  2.318622e-04
## ASV2827      2.661076e-04  2.782330e-04  2.908873e-04  3.040916e-04
## ASV2872      2.160173e-04  2.254483e-04  2.352535e-04  2.454446e-04
## ASV3125      2.564132e-04  2.677403e-04  2.795304e-04  2.917992e-04
## ASV3247      2.793823e-04  2.918006e-04  3.047325e-04  3.181961e-04
## ASV3451     -1.681400e-05 -1.832850e-05 -1.997357e-05 -2.175970e-05
## ASV3465     -3.340737e-05 -3.564828e-05 -3.804958e-05 -4.062288e-05
## ASV3809      1.610718e-04  1.680294e-04  1.752570e-04  1.827625e-04
## ASV4006      3.483223e-04  3.637922e-04  3.798997e-04  3.966667e-04
## ASV4046      2.471030e-04  2.580004e-04  2.693416e-04  2.811416e-04
## ASV4938     -1.841528e-05 -2.000620e-05 -2.173131e-05 -2.360126e-05
## ASV5435     -1.683896e-05 -1.835535e-05 -2.000243e-05 -2.179068e-05
## ASV5605      1.013996e-04  1.054767e-04  1.096845e-04  1.140243e-04
## ASV5635     -1.684259e-05 -1.835913e-05 -2.000635e-05 -2.179472e-05
## ASV5743      3.126696e-04  3.267210e-04  3.413689e-04  3.566358e-04
## ASV6627     -1.685667e-05 -1.837438e-05 -2.002287e-05 -2.181260e-05
## ASV6785     -1.685408e-05 -1.837143e-05 -2.001951e-05 -2.180879e-05
## ASV7368      3.405752e-04  3.563290e-04  3.727927e-04  3.899965e-04
## ASV9118      9.536890e-05  9.923302e-05  1.032250e-04  1.073466e-04
## ASV9135      7.440096e-05  7.718899e-05  8.004680e-05  8.297297e-05
## ASV9435      1.642291e-04  1.711206e-04  1.782597e-04  1.856517e-04
## ASV9671     -1.687980e-05 -1.839925e-05 -2.004958e-05 -2.184126e-05
## ASV0387     -3.464042e-04 -3.617615e-04 -3.777496e-04 -3.943900e-04
## ASV0454     -3.446230e-04 -3.600630e-04 -3.761512e-04 -3.929113e-04
## ASV0751     -2.252476e-04 -2.351304e-04 -2.454098e-04 -2.560985e-04
## ASV1081      9.283604e-05  9.717533e-05  1.017121e-04  1.064547e-04
## ASV1332      1.884240e-04  1.969932e-04  2.059329e-04  2.152573e-04
## ASV2659      3.004393e-04  3.144837e-04  3.291688e-04  3.445220e-04
## ASV2979      3.130365e-04  3.268447e-04  3.412131e-04  3.561604e-04
## ASV4184      1.273358e-04  1.324396e-04  1.377042e-04  1.431309e-04
## ASV6198      1.098781e-04  1.146580e-04  1.196281e-04  1.247946e-04
## ASV7454      2.035218e-04  2.125032e-04  2.218493e-04  2.315722e-04
## ASV8198      8.206580e-05  8.511296e-05  8.823258e-05  9.142253e-05
## ASV0855      4.532535e-04  4.742526e-04  4.961983e-04  5.191310e-04
## ASV10092     1.925740e-04  2.010816e-04  2.099381e-04  2.191557e-04
## ASV1532      2.495957e-04  2.615690e-04  2.741197e-04  2.872757e-04
## ASV2553      6.017550e-04  6.295979e-04  6.586927e-04  6.890926e-04
## ASV2741      2.428969e-04  2.546221e-04  2.669161e-04  2.798062e-04
## ASV4095      1.327768e-04  1.395525e-04  1.466859e-04  1.541963e-04
## ASV5295      1.769381e-04  1.844027e-04  1.921401e-04  2.001567e-04
## ASV5787     -1.693845e-05 -1.846265e-05 -2.011807e-05 -2.191520e-05
## ASV9455      2.342397e-04  2.446565e-04  2.555064e-04  2.668047e-04
## ASV10879     2.428817e-04  2.539192e-04  2.654375e-04  2.774559e-04
## ASV3997      1.690988e-04  1.773216e-04  1.859466e-04  1.949930e-04
## ASV6760      4.844502e-05  4.989345e-05  5.133918e-05  5.277665e-05
## ASV6990      1.760482e-04  1.837171e-04  1.916907e-04  1.999789e-04
## ASV9560      1.096128e-04  1.141930e-04  1.189385e-04  1.238533e-04
## ASV0220      9.965620e-05  1.043233e-04  1.092048e-04  1.143101e-04
## ASV2518      2.371485e-04  2.482509e-04  2.598641e-04  2.720106e-04
## ASV3615      3.711283e-04  3.880673e-04  4.057481e-04  4.242007e-04
## ASV0075      8.612799e-05  8.996585e-05  9.396350e-05  9.812667e-05
## ASV8070      4.516097e-05  4.654702e-05  4.793566e-05  4.932226e-05
## ASV1658      1.761498e-04  1.839729e-04  1.921205e-04  2.006040e-04
## ASV0773      2.889082e-04  3.019158e-04  3.154775e-04  3.296144e-04
## ASV0799      1.020281e-05  1.071257e-05  1.124859e-05  1.181226e-05
## ASV1839     -5.960850e-05 -6.212158e-05 -6.472472e-05 -6.741960e-05
## ASV0265      2.760684e-04  2.896021e-04  3.038121e-04  3.187328e-04
## ASV3741      1.077349e-04  1.125493e-04  1.175641e-04  1.227862e-04
## ASV0847      3.844624e-04  4.021952e-04  4.207194e-04  4.400680e-04
## ASV1026      4.116825e-04  4.305680e-04  4.502866e-04  4.708721e-04
## ASV1222     -1.270855e-04 -1.322471e-04 -1.375809e-04 -1.430897e-04
## ASV0729      5.789580e-05  6.060234e-05  6.343298e-05  6.639321e-05
## ASV0143     -3.143463e-04 -3.283455e-04 -3.429256e-04 -3.581072e-04
## ASV1328      9.197526e-05  9.651898e-05  1.012930e-04  1.063095e-04
## ASV9078     -8.014799e-05 -8.466130e-05 -8.944636e-05 -9.452020e-05
## ASV0027     -4.500125e-04 -4.713163e-04 -4.936191e-04 -5.169664e-04
## ASV0546     -1.953315e-04 -2.039147e-04 -2.128437e-04 -2.221300e-04
## ASV1136      5.005758e-04  5.235422e-04  5.475258e-04  5.725685e-04
## ASV3081      2.366097e-04  2.475303e-04  2.589423e-04  2.708669e-04
## ASV0531      1.062274e-04  1.114188e-04  1.168671e-04  1.225851e-04
## ASV2525      1.382233e-04  1.444287e-04  1.508973e-04  1.576389e-04
## ASV1083     -5.010345e-05 -5.195159e-05 -5.384298e-05 -5.577630e-05
## ASV0424      8.647119e-05  9.040401e-05  9.450742e-05  9.878809e-05
## ASV0644      1.397341e-05  1.523112e-05  1.659717e-05  1.808021e-05
## ASV6007     -1.659791e-05 -1.809267e-05 -1.971630e-05 -2.147912e-05
## ASV0564      1.231587e-04  1.292769e-04  1.357058e-04  1.424616e-04
## ASV1938      1.311510e-04  1.366602e-04  1.423692e-04  1.482826e-04
## ASV6516     -3.052233e-04 -3.192893e-04 -3.339827e-04 -3.493299e-04
## ASV0503     -3.569888e-04 -3.726573e-04 -3.889543e-04 -4.059000e-04
## ASV6913     -3.619038e-04 -3.781510e-04 -3.950894e-04 -4.127456e-04
## ASV0164     -2.794601e-04 -2.927112e-04 -3.065874e-04 -3.211179e-04
## ASV1576      3.384131e-04  3.539789e-04  3.702392e-04  3.872235e-04
## ASV1725      1.666362e-04  1.749669e-04  1.837238e-04  1.929291e-04
## ASV4501      1.424924e-04  1.484564e-04  1.546334e-04  1.610277e-04
## ASV10678    -2.998018e-04 -3.135762e-04 -3.279609e-04 -3.429810e-04
## ASV0944      2.449158e-04  2.565583e-04  2.687523e-04  2.815238e-04
## ASV2292      3.852775e-04  4.027756e-04  4.210308e-04  4.400723e-04
## ASV1090      2.511325e-04  2.627118e-04  2.748090e-04  2.874461e-04
## ASV9117     -1.204696e-04 -1.253769e-04 -1.304493e-04 -1.356895e-04
## ASV0285     -1.521009e-04 -1.599208e-04 -1.681602e-04 -1.768426e-04
## ASV0463     -2.445164e-04 -2.553180e-04 -2.665592e-04 -2.782545e-04
## ASV3199      2.117383e-04  2.209629e-04  2.305525e-04  2.405186e-04
## ASV0150     -8.673984e-05 -9.109330e-05 -9.567157e-05 -1.004865e-04
## ASV6583     -1.217516e-04 -1.268032e-04 -1.320348e-04 -1.374505e-04
## ASV0392      1.989691e-04  2.081219e-04  2.176812e-04  2.276638e-04
## ASV14007    -2.423560e-04 -2.533065e-04 -2.647247e-04 -2.766283e-04
## ASV0177     -1.338091e-04 -1.396043e-04 -1.456242e-04 -1.518754e-04
## ASV6448     -1.052403e-04 -1.109151e-04 -1.169137e-04 -1.232555e-04
## ASV5399     -4.274597e-05 -4.544852e-05 -4.833410e-05 -5.141533e-05
## ASV0277     -4.999381e-05 -5.235466e-05 -5.482526e-05 -5.741050e-05
## ASV2599      9.102729e-05  9.465496e-05  9.839682e-05  1.022539e-04
## ASV13465    -7.235808e-05 -7.506329e-05 -7.783639e-05 -8.067609e-05
## ASV2412      1.260903e-04  1.319621e-04  1.381017e-04  1.445206e-04
## ASV0423      2.458605e-04  2.577523e-04  2.702259e-04  2.833102e-04
## ASV5187      1.516345e-04  1.578617e-04  1.643036e-04  1.709644e-04
## ASV0701     -5.890717e-04 -6.167326e-04 -6.456735e-04 -6.759517e-04
## ASV4248      1.431921e-04  1.504130e-04  1.580089e-04  1.659999e-04
## ASV0519      2.457644e-04  2.575370e-04  2.698733e-04  2.827997e-04
## ASV0764      4.099882e-05  4.319094e-05  4.550771e-05  4.795666e-05
## ASV5385     -3.069830e-04 -3.213756e-04 -3.364332e-04 -3.521855e-04
## ASV3021     -1.774426e-04 -1.849878e-04 -1.928171e-04 -2.009386e-04
## ASV4119     -9.755817e-05 -1.015441e-04 -1.056654e-04 -1.099246e-04
## ASV2534      4.732864e-05  4.930711e-05  5.135738e-05  5.348125e-05
## ASV1061      2.320845e-04  2.436627e-04  2.558372e-04  2.686400e-04
## ASV0670      3.279701e-04  3.433819e-04  3.595086e-04  3.763825e-04
## ASV1384      1.413333e-04  1.484160e-04  1.558624e-04  1.636917e-04
## ASV1981      3.061832e-04  3.207439e-04  3.359935e-04  3.519641e-04
## ASV9632     -9.686078e-05 -1.004427e-04 -1.041107e-04 -1.078626e-04
## ASV4564      7.522257e-05  7.882423e-05  8.259831e-05  8.655297e-05
## ASV5289     -7.035601e-05 -7.374216e-05 -7.729327e-05 -8.101759e-05
## ASV0516      6.202565e-04  6.492276e-04  6.795235e-04  7.112019e-04
## ASV1463     -2.251171e-04 -2.353331e-04 -2.459897e-04 -2.571038e-04
## ASV0969      1.046112e-04  1.092730e-04  1.141277e-04  1.191818e-04
## ASV1113     -2.886404e-04 -3.020949e-04 -3.161629e-04 -3.308711e-04
## ASV1234     -1.175026e-05 -1.300936e-05 -1.439195e-05 -1.590944e-05
## ASV3814      3.980167e-05  4.070373e-05  4.156792e-05  4.238662e-05
## ASV1000      2.961472e-04  3.096637e-04  3.237700e-04  3.384892e-04
## ASV0079     -2.448143e-05 -2.594316e-05 -2.750042e-05 -2.915990e-05
## ASV0145      9.879553e-05  1.029762e-04  1.073120e-04  1.118068e-04
## ASV0457     -3.754025e-04 -3.925011e-04 -4.103427e-04 -4.289564e-04
## ASV1485      1.208607e-04  1.266546e-04  1.327279e-04  1.390943e-04
## ASV0535     -7.864291e-05 -8.199914e-05 -8.548255e-05 -8.909668e-05
## ASV0259     -2.457162e-04 -2.571150e-04 -2.690274e-04 -2.814751e-04
## ASV0570      1.675673e-05  1.785224e-05  1.902556e-05  2.028245e-05
## ASV0906      3.161525e-04  3.305346e-04  3.455407e-04  3.611953e-04
## ASV1748     -1.858930e-04 -1.952124e-04 -2.050127e-04 -2.153191e-04
## ASV5520     -1.093325e-04 -1.151372e-04 -1.212665e-04 -1.277391e-04
## ASV2288     -3.728253e-04 -3.899066e-04 -4.077397e-04 -4.263549e-04
## ASV1887     -7.048760e-05 -7.443710e-05 -7.861974e-05 -8.304941e-05
## ASV0374     -1.142021e-04 -1.191678e-04 -1.243286e-04 -1.296900e-04
## ASV0823      3.559976e-04  3.719495e-04  3.885740e-04  4.058962e-04
## ASV0717      1.781732e-04  1.864977e-04  1.952032e-04  2.043063e-04
## ASV0431      1.270375e-04  1.328687e-04  1.389580e-04  1.453160e-04
## ASV1030      5.190406e-04  5.438607e-04  5.698678e-04  5.971184e-04
## ASV1082     -7.642616e-05 -8.001448e-05 -8.376836e-05 -8.769513e-05
## ASV2684      4.885434e-05  5.170948e-05  5.474163e-05  5.796187e-05
## ASV0051      4.561722e-04  4.775008e-04  4.998092e-04  5.231408e-04
## ASV0513      2.151305e-05  2.271689e-05  2.399445e-05  2.535066e-05
## ASV0581      5.877694e-04  6.153637e-04  6.442341e-04  6.744378e-04
## ASV7282      9.955661e-05  1.046176e-04  1.099471e-04  1.155601e-04
## ASV3009     -3.218225e-04 -3.368375e-04 -3.525383e-04 -3.689547e-04
## ASV2106     -1.630965e-04 -1.702515e-04 -1.776965e-04 -1.854414e-04
## ASV1012      1.031323e-04  1.082777e-04  1.136852e-04  1.193683e-04
## ASV0921     -7.034997e-06 -7.235483e-06 -7.432737e-06 -7.625409e-06
## ASV0010     -4.572524e-04 -4.789058e-04 -5.015755e-04 -5.253080e-04
## ASV1178      1.059163e-05  1.130782e-05  1.207526e-05  1.289761e-05
## ASV2848     -2.448067e-04 -2.558311e-04 -2.673276e-04 -2.793148e-04
## ASV0586      6.659084e-04  6.972351e-04  7.300166e-04  7.643189e-04
## ASV4225      3.267767e-05  3.512848e-05  3.776785e-05  4.060980e-05
## ASV2156     -2.784996e-04 -2.916068e-04 -3.053231e-04 -3.196763e-04
## ASV9778     -1.753772e-04 -1.834648e-04 -1.919137e-04 -2.007389e-04
## ASV0493     -3.847791e-04 -4.022201e-04 -4.204130e-04 -4.393872e-04
## ASV3770      6.409511e-05  6.649870e-05  6.896394e-05  7.148993e-05
## ASV0470      4.708544e-04  4.927326e-04  5.156026e-04  5.395070e-04
## ASV0262     -1.972395e-04 -2.071468e-04 -2.175672e-04 -2.285278e-04
## ASV0998      2.891526e-04  3.027544e-04  3.169884e-04  3.318830e-04
## ASV7708     -7.666985e-05 -8.000419e-05 -8.346860e-05 -8.706680e-05
## ASV0453     -8.603295e-06 -8.913256e-06 -9.231411e-06 -9.557906e-06
## ASV0044      5.907000e-04  6.181261e-04  6.467931e-04  6.767543e-04
## ASV5490      9.393118e-05  9.815528e-05  1.025572e-04  1.071434e-04
## ASV2638      2.972961e-05  3.146331e-05  3.330499e-05  3.526157e-05
## ASV0829     -5.254646e-05 -5.458798e-05 -5.668877e-05 -5.884884e-05
## ASV0601      1.075313e-04  1.127148e-04  1.181505e-04  1.238509e-04
## ASV0234      2.609157e-04  2.731278e-04  2.859017e-04  2.992623e-04
## ASV0133      3.384919e-04  3.542354e-04  3.706933e-04  3.878964e-04
## ASV0323      3.592630e-04  3.763447e-04  3.942372e-04  4.129791e-04
## ASV0854     -2.937986e-05 -3.064449e-05 -3.195729e-05 -3.331949e-05
## ASV0110      4.528268e-04  4.740532e-04  4.962587e-04  5.194870e-04
## ASV0816      2.491700e-05  2.601510e-05  2.715780e-05  2.834659e-05
## ASV1031     -6.895054e-05 -7.187376e-05 -7.490598e-05 -7.805009e-05
## ASV0144     -1.872368e-04 -1.959257e-04 -2.050079e-04 -2.145005e-04
## ASV0020     -8.238086e-05 -8.662232e-05 -9.109578e-05 -9.581506e-05
## ASV0962     -1.526228e-04 -1.597029e-04 -1.671020e-04 -1.748337e-04
## ASV0794      3.003521e-04  3.149815e-04  3.303321e-04  3.464398e-04
## ASV7117     -1.512370e-04 -1.581318e-04 -1.653273e-04 -1.728356e-04
## ASV1008     -1.104835e-04 -1.158452e-04 -1.214707e-04 -1.273732e-04
## ASV0096      4.873015e-04  5.101367e-04  5.340244e-04  5.590117e-04
## ASV0128     -2.921802e-04 -3.063246e-04 -3.211636e-04 -3.367322e-04
## ASV5232      2.277209e-04  2.387466e-04  2.503109e-04  2.624401e-04
## ASV0031      1.736732e-05  1.805756e-05  1.876862e-05  1.950049e-05
## ASV1744     -3.014933e-05 -3.147978e-05 -3.286727e-05 -3.431441e-05
## ASV0289      2.724605e-04  2.852014e-04  2.985288e-04  3.124689e-04
## ASV7413     -6.340278e-05 -6.712325e-05 -7.107897e-05 -7.528546e-05
## ASV0822     -3.300597e-04 -3.449534e-04 -3.604814e-04 -3.766674e-04
## ASV8111     -2.894932e-04 -3.025091e-04 -3.160802e-04 -3.302281e-04
## ASV0687      2.078013e-04  2.178640e-04  2.284176e-04  2.394862e-04
## ASV0112      7.535428e-05  7.860700e-05  8.198437e-05  8.548969e-05
## ASV0987      1.673302e-04  1.754530e-04  1.839767e-04  1.929216e-04
## ASV5332     -8.572352e-05 -8.905502e-05 -9.248614e-05 -9.601768e-05
## ASV1129     -2.148966e-04 -2.249420e-04 -2.354497e-04 -2.464405e-04
## ASV1274     -6.978350e-05 -7.301953e-05 -7.640167e-05 -7.993615e-05
## ASV0119      3.971402e-04  4.157308e-04  4.351766e-04  4.555156e-04
## ASV0890      9.841007e-05  1.030589e-04  1.079246e-04  1.130169e-04
## ASV0848      5.770518e-04  6.041698e-04  6.325445e-04  6.622324e-04
## ASV5944     -3.133283e-04 -3.278090e-04 -3.429392e-04 -3.587463e-04
## ASV19741    -2.985657e-04 -3.123322e-04 -3.267135e-04 -3.417351e-04
## ASV0504     -3.441356e-04 -3.597068e-04 -3.759467e-04 -3.928811e-04
## ASV2146     -2.210239e-04 -2.308862e-04 -2.411635e-04 -2.518715e-04
## ASV0089     -1.835593e-04 -1.921975e-04 -2.012368e-04 -2.106952e-04
## ASV2301     -2.001598e-04 -2.096360e-04 -2.195577e-04 -2.299457e-04
## ASV2982      7.387885e-05  7.818701e-05  8.276337e-05  8.762508e-05
## ASV0891     -2.512879e-04 -2.629260e-04 -2.750878e-04 -2.877955e-04
## ASV0093      4.101059e-04  4.291926e-04  4.491477e-04  4.700090e-04
## ASV0042      1.987278e-04  2.079825e-04  2.176586e-04  2.277745e-04
## ASV0980      2.724278e-04  2.848390e-04  2.977891e-04  3.112992e-04
## ASV0069     -6.575818e-05 -6.892506e-05 -7.224542e-05 -7.572674e-05
## ASV1364     -4.532024e-05 -4.731365e-05 -4.938687e-05 -5.154235e-05
## ASV0524     -7.779293e-05 -8.159163e-05 -8.557964e-05 -8.976667e-05
## ASV0435      5.450014e-04  5.706749e-04  5.975443e-04  6.256640e-04
## ASV0517     -2.231760e-04 -2.337010e-04 -2.447176e-04 -2.562480e-04
## ASV3167     -9.777846e-05 -1.026139e-04 -1.076940e-04 -1.130315e-04
## ASV4280     -3.343433e-05 -3.487610e-05 -3.637363e-05 -3.792859e-05
## ASV1158      1.350640e-04  1.418429e-04  1.489691e-04  1.564602e-04
## ASV2214      9.878574e-05  1.032281e-04  1.078612e-04  1.126925e-04
## ASV0544     -1.246286e-04 -1.306344e-04 -1.369322e-04 -1.435363e-04
## ASV5326     -2.261253e-05 -2.365318e-05 -2.474059e-05 -2.587683e-05
## ASV3765     -3.249369e-04 -3.401024e-04 -3.559607e-04 -3.725421e-04
## ASV4646     -7.218348e-06 -8.058696e-06 -8.979626e-06 -9.987921e-06
## ASV0090      3.421892e-05  3.565969e-05  3.715169e-05  3.869582e-05
## ASV3680      2.991159e-04  3.124009e-04  3.262328e-04  3.406302e-04
## ASV0111      5.172086e-05  5.399294e-05  5.635564e-05  5.881171e-05
## ASV0768      1.883297e-04  1.973205e-04  2.067416e-04  2.166135e-04
## ASV4862     -9.603760e-06 -9.906688e-06 -1.020957e-05 -1.051107e-05
## ASV1742     -2.436803e-04 -2.544894e-04 -2.657454e-04 -2.774642e-04
## ASV3701     -3.446383e-05 -3.575198e-05 -3.707267e-05 -3.842533e-05
## ASV2386     -1.492053e-04 -1.561592e-04 -1.634298e-04 -1.710306e-04
## ASV0375     -3.469794e-04 -3.627381e-04 -3.791807e-04 -3.963345e-04
## ASV2796      8.937648e-05  9.324687e-05  9.726967e-05  1.014498e-04
## ASV1369      2.384191e-04  2.492263e-04  2.605029e-04  2.722680e-04
## ASV10272    -2.170954e-04 -2.270989e-04 -2.375476e-04 -2.484598e-04
## ASV10354    -2.170776e-04 -2.270794e-04 -2.375263e-04 -2.484365e-04
## ASV1067     -1.645355e-05 -1.720413e-05 -1.798729e-05 -1.880428e-05
## ASV1900      4.535392e-04  4.748882e-04  4.972302e-04  5.206103e-04
## ASV4079     -7.744034e-05 -8.116944e-05 -8.507907e-05 -8.917796e-05
## ASV4149      3.058783e-04  3.195532e-04  3.337985e-04  3.486344e-04
## ASV5140     -2.170600e-04 -2.270602e-04 -2.375052e-04 -2.484134e-04
## ASV10782    -8.656507e-06 -8.847578e-06 -9.027216e-06 -9.193024e-06
## ASV4273     -5.024476e-05 -5.240480e-05 -5.464612e-05 -5.697063e-05
## ASV8121      2.081029e-04  2.178578e-04  2.280633e-04  2.387395e-04
## ASV8438     -2.170443e-04 -2.270431e-04 -2.374865e-04 -2.483930e-04
## ASV9390     -2.170265e-04 -2.270236e-04 -2.374652e-04 -2.483697e-04
## ASV1340      3.001161e-04  3.143208e-04  3.291930e-04  3.447635e-04
## ASV2650     -3.228978e-04 -3.376171e-04 -3.529767e-04 -3.690017e-04
## ASV4674      1.643815e-04  1.720358e-04  1.800382e-04  1.884037e-04
## ASV10492    -1.192686e-05 -1.243239e-05 -1.295651e-05 -1.349968e-05
## ASV11430    -2.170002e-04 -2.269948e-04 -2.374338e-04 -2.483354e-04
## ASV12135    -2.169824e-04 -2.269754e-04 -2.374125e-04 -2.483121e-04
## ASV14970    -2.169646e-04 -2.269559e-04 -2.373912e-04 -2.482888e-04
## ASV1954      2.476891e-04  2.592809e-04  2.714051e-04  2.840852e-04
## ASV2613      3.863609e-04  4.043065e-04  4.230643e-04  4.426692e-04
## ASV2757      1.536256e-04  1.605137e-04  1.676911e-04  1.751683e-04
## ASV2909     -2.285206e-04 -2.393541e-04 -2.506986e-04 -2.625783e-04
## ASV2954     -4.494661e-05 -4.695799e-05 -4.905316e-05 -5.123505e-05
## ASV2969      2.137303e-04  2.239491e-04  2.346578e-04  2.458799e-04
## ASV3410      4.394052e-05  4.613441e-05  4.844198e-05  5.086946e-05
## ASV3575      1.123868e-04  1.176043e-04  1.230581e-04  1.287586e-04
## ASV4275      2.485688e-04  2.598367e-04  2.715889e-04  2.838438e-04
## ASV4652      4.190915e-05  4.403259e-05  4.626854e-05  4.862332e-05
## ASV4761      2.483303e-04  2.596029e-04  2.713610e-04  2.836229e-04
## ASV6003      1.885494e-04  1.976496e-04  2.071942e-04  2.172051e-04
## ASV6110     -2.170025e-04 -2.269975e-04 -2.374368e-04 -2.483388e-04
## ASV7427      1.404040e-04  1.468973e-04  1.536817e-04  1.607696e-04
## ASV8092     -2.169910e-04 -2.269849e-04 -2.374230e-04 -2.483237e-04
## ASV8169     -2.169732e-04 -2.269654e-04 -2.374017e-04 -2.483004e-04
## ASV9693      9.448126e-05  9.890778e-05  1.035381e-04  1.083811e-04
## ASV10913     1.027301e-04  1.076504e-04  1.128073e-04  1.182121e-04
## ASV1979     -3.492196e-05 -3.645529e-05 -3.805007e-05 -3.970825e-05
## ASV3772      2.684002e-04  2.807016e-04  2.935450e-04  3.069525e-04
## ASV0113      5.381131e-05  5.625353e-05  5.880138e-05  6.145896e-05
## ASV1800     -2.135662e-05 -2.233056e-05 -2.334528e-05 -2.440202e-05
## ASV2335     -2.839396e-04 -2.967717e-04 -3.101568e-04 -3.241169e-04
## ASV0692      9.190149e-05  9.622066e-05  1.007396e-04  1.054672e-04
## ASV1120      1.188870e-04  1.244786e-04  1.303300e-04  1.364529e-04
## ASV1434     -6.286543e-04 -6.581323e-04 -6.889710e-04 -7.212314e-04
## ASV0076     -6.918719e-05 -7.250763e-05 -7.598796e-05 -7.963590e-05
## ASV0361      4.701051e-04  4.921881e-04  5.152941e-04  5.394692e-04
## ASV2231     -1.554035e-04 -1.631130e-04 -1.712172e-04 -1.797374e-04
## ASV2018     -6.662047e-06 -7.000212e-06 -7.356701e-06 -7.732627e-06
## ASV1529      3.925507e-04  4.112262e-04  4.307889e-04  4.512807e-04
## ASV0841     -1.974112e-05 -2.052745e-05 -2.133720e-05 -2.217024e-05
## ASV2556     -2.360974e-04 -2.470005e-04 -2.583911e-04 -2.702896e-04
## ASV2777      2.988035e-04  3.121069e-04  3.259601e-04  3.403818e-04
## ASV0355      2.421693e-04  2.535183e-04  2.653909e-04  2.778104e-04
## ASV5169     -3.379581e-04 -3.537254e-04 -3.702124e-04 -3.874503e-04
## ASV3091      1.621039e-04  1.698476e-04  1.779622e-04  1.864654e-04
## ASV2435      2.396598e-04  2.508148e-04  2.624767e-04  2.746675e-04
## ASV6822     -1.519646e-04 -1.589109e-04 -1.661608e-04 -1.737265e-04
## ASV12605    -3.677948e-04 -3.849324e-04 -4.028506e-04 -4.215834e-04
## ASV0286     -2.435483e-04 -2.548038e-04 -2.665663e-04 -2.788577e-04
## ASV0074     -9.377282e-06 -1.008992e-05 -1.085976e-05 -1.169143e-05
## ASV2485     -1.784023e-05 -1.883649e-05 -1.989561e-05 -2.102220e-05
## ASV1233     -4.672804e-04 -4.891642e-04 -5.120567e-04 -5.360033e-04
## ASV0356     -2.226150e-04 -2.327856e-04 -2.434029e-04 -2.544852e-04
## ASV2918     -2.834937e-04 -2.965788e-04 -3.102493e-04 -3.245296e-04
## ASV1427      1.066156e-06  1.046205e-06  1.018620e-06  9.824130e-07
## ASV1409      2.708099e-04  2.836883e-04  2.971780e-04  3.113079e-04
## ASV0770      8.886341e-05  9.283245e-05  9.696623e-05  1.012704e-04
## ASV1403     -3.285919e-04 -3.438461e-04 -3.597902e-04 -3.764537e-04
## ASV0314     -1.780090e-04 -1.863229e-04 -1.950168e-04 -2.041071e-04
## ASV0187      4.366087e-06  4.318415e-06  4.246771e-06  4.148319e-06
## ASV0313     -2.423814e-04 -2.536006e-04 -2.653240e-04 -2.775730e-04
## ASV1087      4.138220e-04  4.331782e-04  4.534235e-04  4.745971e-04
## ASV1970      2.443633e-05  2.555449e-05  2.672210e-05  2.794121e-05
## ASV0754      3.335716e-04  3.491986e-04  3.655456e-04  3.826447e-04
## ASV3775     -2.272705e-04 -2.380497e-04 -2.493377e-04 -2.611584e-04
## ASV0132      9.639689e-05  1.008833e-04  1.055735e-04  1.104765e-04
## ASV2329     -6.271565e-05 -6.608818e-05 -6.965191e-05 -7.341802e-05
## ASV0561      2.899684e-04  3.033951e-04  3.174254e-04  3.320848e-04
## ASV0130     -3.516843e-04 -3.682397e-04 -3.855645e-04 -4.036934e-04
## ASV0226      3.969507e-04  4.154924e-04  4.348831e-04  4.551599e-04
## ASV12648    -2.789435e-04 -2.916738e-04 -3.049638e-04 -3.188367e-04
## ASV0204      3.957722e-04  4.142556e-04  4.335849e-04  4.537973e-04
## ASV0767      7.106132e-05  7.420752e-05  7.748151e-05  8.088741e-05
## ASV0335     -2.157994e-04 -2.259128e-04 -2.364918e-04 -2.475572e-04
## ASV5901     -6.565526e-05 -6.849992e-05 -7.145686e-05 -7.452971e-05
## ASV0596     -8.777033e-05 -9.166433e-05 -9.571753e-05 -9.993517e-05
## ASV9271      8.244312e-05  8.684552e-05  9.149662e-05  9.641112e-05
## ASV0904      3.506429e-04  3.672362e-04  3.846095e-04  4.027989e-04
## ASV15270    -9.552524e-05 -1.004841e-04 -1.057106e-04 -1.112195e-04
## ASV0990     -9.820757e-05 -1.028668e-04 -1.077461e-04 -1.128559e-04
## ASV0155     -2.118888e-04 -2.217912e-04 -2.321477e-04 -2.429784e-04
## ASV0086     -3.012436e-06 -3.161288e-06 -3.317667e-06 -3.481961e-06
## ASV2581     -1.759258e-05 -1.836934e-05 -1.917680e-05 -2.001576e-05
## ASV1579     -2.451307e-04 -2.568300e-04 -2.690877e-04 -2.819304e-04
## ASV7730     -9.033849e-06 -9.830264e-06 -1.069286e-05 -1.162659e-05
## ASV0897      1.032460e-04  1.081969e-04  1.133865e-04  1.188263e-04
## ASV1975      4.791084e-04  5.015136e-04  5.249492e-04  5.494611e-04
##                                                                    
## (Intercept)  1.620696e-06  1.722053e-06  1.816200e-06  1.898856e-06
## ASV1236      2.638143e-04  2.756978e-04  2.880847e-04  3.009935e-04
## ASV0421     -4.718522e-04 -4.933478e-04 -5.157776e-04 -5.391780e-04
## ASV0691     -4.052986e-04 -4.231264e-04 -4.416711e-04 -4.609557e-04
## ASV0899     -1.317925e-06 -9.212963e-07 -4.666773e-07  5.173628e-08
## ASV1004      5.336187e-04  5.578111e-04  5.830428e-04  6.093534e-04
## ASV1041     -3.631187e-04 -3.796887e-04 -3.969801e-04 -4.150212e-04
## ASV1058      4.968359e-04  5.194094e-04  5.429582e-04  5.675200e-04
## ASV12542     1.528199e-04  1.596030e-04  1.666649e-04  1.740152e-04
## ASV1294      5.786844e-04  6.051945e-04  6.328696e-04  6.617566e-04
## ASV13113     2.093426e-04  2.193413e-04  2.298192e-04  2.407992e-04
## ASV1318      5.042400e-04  5.271939e-04  5.511428e-04  5.761253e-04
## ASV2269     -1.507363e-04 -1.576316e-04 -1.648280e-04 -1.723372e-04
## ASV2542      3.250926e-04  3.403879e-04  3.563936e-04  3.731417e-04
## ASV2660     -2.909195e-04 -3.040524e-04 -3.177439e-04 -3.320148e-04
## ASV2737     -1.613932e-05 -1.703891e-05 -1.799164e-05 -1.900072e-05
## ASV2840      3.867841e-04  4.041563e-04  4.222596e-04  4.411206e-04
## ASV3053      2.073194e-05  2.161798e-05  2.253802e-05  2.349310e-05
## ASV3077      1.204143e-04  1.258478e-04  1.315133e-04  1.374196e-04
## ASV3134      4.205937e-04  4.405550e-04  4.614608e-04  4.833554e-04
## ASV3140      1.848864e-04  1.935926e-04  2.027022e-04  2.122332e-04
## ASV3579      7.398074e-05  7.768203e-05  8.157624e-05  8.567406e-05
## ASV6119     -1.507073e-04 -1.576000e-04 -1.647934e-04 -1.722995e-04
## ASV7557     -1.506925e-04 -1.575838e-04 -1.647757e-04 -1.722802e-04
## ASV8422      8.123141e-05  8.473786e-05  8.838013e-05  9.216218e-05
## ASV1086     -4.170511e-05 -4.354388e-05 -4.545776e-05 -4.744932e-05
## ASV1310      2.848204e-04  2.978178e-04  3.113816e-04  3.255339e-04
## ASV15750    -7.139931e-05 -7.462291e-05 -7.798259e-05 -8.148314e-05
## ASV16905    -1.506864e-04 -1.575771e-04 -1.647684e-04 -1.722721e-04
## ASV2033      2.817895e-04  2.950119e-04  3.088453e-04  3.233172e-04
## ASV2089      1.032932e-04  1.080360e-04  1.129873e-04  1.181552e-04
## ASV2127      4.091625e-04  4.277359e-04  4.471104e-04  4.673167e-04
## ASV2725      4.630727e-04  4.838326e-04  5.054636e-04  5.279970e-04
## ASV2804     -1.506825e-04 -1.575728e-04 -1.647637e-04 -1.722670e-04
## ASV3075      2.935526e-04  3.069562e-04  3.209466e-04  3.355472e-04
## ASV3327      2.765637e-04  2.895448e-04  3.031269e-04  3.173372e-04
## ASV3342      3.013363e-04  3.153607e-04  3.300215e-04  3.453462e-04
## ASV3532     -2.727542e-04 -2.854734e-04 -2.987723e-04 -3.126760e-04
## ASV3600      3.433192e-04  3.591796e-04  3.757507e-04  3.930624e-04
## ASV4013      2.888402e-04  3.020213e-04  3.157775e-04  3.301314e-04
## ASV4136      2.855519e-04  2.983924e-04  3.117751e-04  3.257198e-04
## ASV4195      1.506611e-04  1.575494e-04  1.647382e-04  1.722391e-04
## ASV4407     -1.506463e-04 -1.575332e-04 -1.647205e-04 -1.722198e-04
## ASV4717      6.255327e-06  6.332514e-06  6.395247e-06  6.441502e-06
## ASV6794      1.517023e-04  1.582918e-04  1.651397e-04  1.722537e-04
## ASV8324     -1.506415e-04 -1.575279e-04 -1.647146e-04 -1.722132e-04
## ASV8981     -4.086492e-05 -4.259973e-05 -4.439690e-05 -4.625752e-05
## ASV9859      1.162740e-04  1.219774e-04  1.279683e-04  1.342617e-04
## ASV0936     -2.363965e-04 -2.472375e-04 -2.585569e-04 -2.703744e-04
## ASV12683    -2.458128e-05 -2.580590e-05 -2.709235e-05 -2.844369e-05
## ASV1293      3.468318e-04  3.625180e-04  3.788745e-04  3.959266e-04
## ASV13055    -3.672471e-05 -3.834339e-05 -4.002605e-05 -4.177446e-05
## ASV17063    -1.506163e-04 -1.575004e-04 -1.646846e-04 -1.721806e-04
## ASV2228      1.506015e-04  1.574842e-04  1.646670e-04  1.721613e-04
## ASV2769     -2.874399e-05 -2.995534e-05 -3.120942e-05 -3.250688e-05
## ASV2803      6.946526e-05  7.242755e-05  7.550111e-05  7.868885e-05
## ASV2896      1.884031e-04  1.971213e-04  2.062329e-04  2.157550e-04
## ASV3062      5.755314e-05  6.042239e-05  6.344029e-05  6.661498e-05
## ASV3107      2.280026e-04  2.386019e-04  2.496825e-04  2.612653e-04
## ASV3265      4.518421e-04  4.723013e-04  4.936377e-04  5.158845e-04
## ASV3666     -1.020263e-05 -1.069332e-05 -1.120713e-05 -1.174504e-05
## ASV4497      1.073466e-04  1.122364e-04  1.173394e-04  1.226642e-04
## ASV6914     -5.330732e-05 -5.582400e-05 -5.845738e-05 -6.121259e-05
## ASV0576     -5.297736e-04 -5.532699e-04 -5.777293e-04 -6.031845e-04
## ASV0673      1.416999e-04  1.486049e-04  1.558510e-04  1.634551e-04
## ASV0772      1.606535e-04  1.679867e-04  1.756411e-04  1.836297e-04
## ASV0862     -1.305130e-04 -1.362891e-04 -1.423007e-04 -1.485557e-04
## ASV0898      1.341396e-04  1.405788e-04  1.473281e-04  1.544021e-04
## ASV0910      2.901020e-04  3.038731e-04  3.182952e-04  3.333984e-04
## ASV0964     -1.939145e-04 -2.026653e-04 -2.117889e-04 -2.212993e-04
## ASV10059     1.365682e-04  1.431344e-04  1.500198e-04  1.572402e-04
## ASV10263    -1.506809e-04 -1.575711e-04 -1.647620e-04 -1.722652e-04
## ASV1088      1.535909e-04  1.608821e-04  1.685192e-04  1.765188e-04
## ASV1101      2.609479e-04  2.729405e-04  2.854631e-04  2.985371e-04
## ASV1183      1.678028e-04  1.756195e-04  1.837910e-04  1.923325e-04
## ASV11956     6.252060e-05  6.510825e-05  6.778564e-05  7.055437e-05
## ASV12774    -2.337621e-05 -2.454811e-05 -2.578011e-05 -2.707532e-05
## ASV1321      6.690675e-05  7.030839e-05  7.389131e-05  7.766575e-05
## ASV13793    -1.506632e-04 -1.575517e-04 -1.647407e-04 -1.722419e-04
## ASV14482    -1.492000e-05 -1.573850e-05 -1.660415e-05 -1.751969e-05
## ASV15483     1.058105e-04  1.107510e-04  1.159186e-04  1.213234e-04
## ASV2062      6.635567e-04  6.940671e-04  7.259293e-04  7.591986e-04
## ASV2132      3.031624e-04  3.173684e-04  3.322298e-04  3.477760e-04
## ASV2413      4.275017e-04  4.468856e-04  4.671043e-04  4.881899e-04
## ASV2490      2.793013e-04  2.917287e-04  3.046687e-04  3.181387e-04
## ASV2594      1.541054e-04  1.611636e-04  1.685342e-04  1.762301e-04
## ASV2822     -1.506871e-04 -1.575779e-04 -1.647694e-04 -1.722734e-04
## ASV2863      2.610201e-04  2.727924e-04  2.850648e-04  2.978557e-04
## ASV2910      3.398868e-04  3.551754e-04  3.711108e-04  3.877169e-04
## ASV2980      1.241685e-04  1.298101e-04  1.356941e-04  1.418298e-04
## ASV3307      1.506624e-04  1.575509e-04  1.647399e-04  1.722411e-04
## ASV3474      2.357104e-04  2.468934e-04  2.586047e-04  2.708692e-04
## ASV3502      4.904571e-04  5.130763e-04  5.367046e-04  5.613842e-04
## ASV4236      2.486514e-04  2.598631e-04  2.715515e-04  2.837342e-04
## ASV4842     -8.321166e-05 -8.709409e-05 -9.115237e-05 -9.539385e-05
## ASV4894     -1.506792e-04 -1.575693e-04 -1.647600e-04 -1.722632e-04
## ASV5290      1.840496e-04  1.924984e-04  2.013212e-04  2.105331e-04
## ASV5501      3.449613e-05  3.607209e-05  3.771801e-05  3.943691e-05
## ASV5795      1.240426e-04  1.298385e-04  1.359006e-04  1.422407e-04
## ASV5987     -1.506847e-04 -1.575754e-04 -1.647667e-04 -1.722705e-04
## ASV6267     -1.506699e-04 -1.575592e-04 -1.647490e-04 -1.722512e-04
## ASV6862      2.872531e-04  2.999665e-04  3.131990e-04  3.269679e-04
## ASV7145      5.099128e-05  5.312118e-05  5.532726e-05  5.761118e-05
## ASV7673     -1.506655e-04 -1.575543e-04 -1.647436e-04 -1.722452e-04
## ASV7789      5.465886e-05  5.742517e-05  6.033864e-05  6.340770e-05
## ASV7809     -1.934318e-05 -2.011803e-05 -2.091562e-05 -2.173570e-05
## ASV8002     -1.506542e-04 -1.575420e-04 -1.647302e-04 -1.722307e-04
## ASV8205      8.581772e-05  8.970548e-05  9.376166e-05  9.799296e-05
## ASV9155     -1.134620e-04 -1.186285e-04 -1.240181e-04 -1.296392e-04
## ASV9221     -1.950089e-05 -2.034044e-05 -2.121118e-05 -2.211374e-05
## ASV9311     -1.506336e-04 -1.575195e-04 -1.647057e-04 -1.722038e-04
## ASV9557     -1.506188e-04 -1.575033e-04 -1.646880e-04 -1.721845e-04
## ASV9936     -1.506040e-04 -1.574872e-04 -1.646703e-04 -1.721652e-04
## ASV1445      3.473839e-04  3.635714e-04  3.804969e-04  3.981926e-04
## ASV4232      2.925704e-04  3.063329e-04  3.207360e-04  3.358092e-04
## ASV6479      1.506309e-07  5.122123e-07  9.239135e-07  1.391065e-06
## ASV0142     -7.569172e-04 -7.909537e-04 -8.264286e-04 -8.633944e-04
## ASV0378     -2.502827e-04 -2.615084e-04 -2.732048e-04 -2.853886e-04
## ASV1122      4.587385e-04  4.801133e-04  5.024619e-04  5.258267e-04
## ASV0123     -7.414895e-04 -7.748121e-04 -8.095412e-04 -8.457278e-04
## ASV2064      7.407086e-05  7.717913e-05  8.040098e-05  8.373925e-05
## ASV4459     -8.361195e-05 -8.745329e-05 -9.146361e-05 -9.564958e-05
## ASV0448      1.323330e-04  1.388961e-04  1.457940e-04  1.530443e-04
## ASV0397      3.440696e-04  3.600526e-04  3.767587e-04  3.942187e-04
## ASV0485      4.785897e-04  5.004911e-04  5.233539e-04  5.472169e-04
## ASV1566      4.015356e-04  4.200969e-04  4.394899e-04  4.597494e-04
## ASV1365      2.587902e-04  2.707178e-04  2.831772e-04  2.961905e-04
## ASV1065      5.338582e-04  5.586051e-04  5.844668e-04  6.114908e-04
## ASV0722     -1.120490e-05 -1.166695e-05 -1.214573e-05 -1.264174e-05
## ASV12660    -2.497257e-04 -2.609198e-04 -2.725831e-04 -2.847323e-04
## ASV0223     -9.477297e-06 -9.863902e-06 -1.026332e-05 -1.067569e-05
## ASV0229      2.391840e-04  2.504092e-04  2.621530e-04  2.744383e-04
## ASV0877     -9.493938e-05 -9.926513e-05 -1.037763e-04 -1.084798e-04
## ASV0983      4.885831e-04  5.108447e-04  5.340735e-04  5.583070e-04
## ASV0626     -1.586965e-04 -1.654221e-04 -1.723929e-04 -1.796141e-04
## ASV4146     -2.805627e-05 -2.935930e-05 -3.072076e-05 -3.214308e-05
## ASV4175     -2.993970e-04 -3.131793e-04 -3.275727e-04 -3.426023e-04
## ASV2082     -2.118701e-05 -2.234164e-05 -2.356590e-05 -2.486456e-05
## ASV2272      2.152241e-04  2.252024e-04  2.356315e-04  2.465308e-04
## ASV2245     -2.612895e-04 -2.734026e-04 -2.860609e-04 -2.992871e-04
## ASV0590     -1.586999e-04 -1.663677e-04 -1.744107e-04 -1.828476e-04
## ASV0217     -2.396368e-04 -2.496219e-04 -2.599546e-04 -2.706406e-04
## ASV0416      2.422447e-04  2.528644e-04  2.639068e-04  2.753847e-04
## ASV1056      2.913582e-04  3.052560e-04  3.198168e-04  3.350720e-04
## ASV7777     -2.610933e-04 -2.732571e-04 -2.859745e-04 -2.992692e-04
## ASV0455      5.234932e-05  5.488503e-05  5.754374e-05  6.033129e-05
## ASV0604      5.880700e-05  6.194258e-05  6.525715e-05  6.876168e-05
## ASV6100     -2.409698e-04 -2.522108e-04 -2.639646e-04 -2.762532e-04
## ASV11359    -2.665829e-04 -2.787778e-04 -2.915063e-04 -3.047895e-04
## ASV6604      1.907276e-04  1.997064e-04  2.091036e-04  2.189381e-04
## ASV5004     -1.576701e-04 -1.649290e-04 -1.725096e-04 -1.804249e-04
## ASV1483     -1.465081e-04 -1.533352e-04 -1.604726e-04 -1.679339e-04
## ASV9773     -3.081084e-04 -3.224307e-04 -3.374015e-04 -3.530487e-04
## ASV4059      2.911937e-05  3.065232e-05  3.227189e-05  3.398344e-05
## ASV1193      5.000840e-04  5.232193e-04  5.473933e-04  5.726500e-04
## ASV4610     -4.306039e-05 -4.463996e-05 -4.625294e-05 -4.789744e-05
## ASV0742     -1.853361e-04 -1.932893e-04 -2.015423e-04 -2.101026e-04
## ASV1502     -3.687972e-06 -4.059088e-06 -4.464833e-06 -4.908239e-06
## ASV0195     -5.607112e-05 -5.893383e-05 -6.194943e-05 -6.512651e-05
## ASV1213      1.576047e-04  1.645826e-04  1.718441e-04  1.793985e-04
## ASV1648     -2.281744e-04 -2.387618e-04 -2.498270e-04 -2.613905e-04
## ASV6984     -1.704794e-04 -1.784148e-04 -1.867105e-04 -1.953819e-04
## ASV0396     -1.224668e-04 -1.271420e-04 -1.319384e-04 -1.368535e-04
## ASV4297      2.549441e-04  2.663667e-04  2.782689e-04  2.906682e-04
## ASV2622      5.823759e-04  6.087439e-04  6.362433e-04  6.649170e-04
## ASV3512      8.899206e-05  9.338145e-05  9.799409e-05  1.028419e-04
## ASV2411      2.003590e-04  2.098292e-04  2.197427e-04  2.301195e-04
## ASV2291     -5.110918e-05 -5.368381e-05 -5.639460e-05 -5.924928e-05
## ASV0807      2.379761e-04  2.495899e-04  2.617793e-04  2.745730e-04
## ASV1292      1.324506e-04  1.384900e-04  1.447924e-04  1.513682e-04
## ASV1035      5.979146e-05  6.230070e-05  6.489928e-05  6.758892e-05
## ASV0070     -1.381591e-04 -1.440897e-04 -1.502435e-04 -1.566259e-04
## ASV0255      5.499560e-05  5.745688e-05  6.001995e-05  6.268817e-05
## ASV0057     -5.990321e-04 -6.256956e-04 -6.534593e-04 -6.823609e-04
## ASV0077     -8.763265e-05 -9.127061e-05 -9.503334e-05 -9.892257e-05
## ASV0625      5.976977e-04  6.246075e-04  6.526563e-04  6.818857e-04
## ASV2464      2.888169e-04  3.016437e-04  3.149977e-04  3.288968e-04
## ASV1315      5.145222e-04  5.384329e-04  5.634315e-04  5.895658e-04
## ASV2673      3.815405e-04  3.996612e-04  4.186400e-04  4.385174e-04
## ASV2161      1.580152e-04  1.655885e-04  1.735269e-04  1.818482e-04
## ASV0337     -2.517253e-04 -2.633098e-04 -2.754089e-04 -2.880438e-04
## ASV7680     -2.961304e-04 -3.099272e-04 -3.243517e-04 -3.394312e-04
## ASV0611      6.435116e-04  6.737067e-04  7.052972e-04  7.383456e-04
## ASV3118     -2.193784e-04 -2.296856e-04 -2.404697e-04 -2.517518e-04
## ASV1284      2.391820e-04  2.506853e-04  2.627386e-04  2.753673e-04
## ASV0889      1.744173e-04  1.823554e-04  1.906388e-04  1.992813e-04
## ASV4649     -1.841475e-04 -1.927071e-04 -2.016542e-04 -2.110056e-04
## ASV1108     -2.358431e-04 -2.471228e-04 -2.589431e-04 -2.713300e-04
## ASV0738     -3.190084e-05 -3.247352e-05 -3.298861e-05 -3.343612e-05
## ASV0473      3.428262e-05  3.579188e-05  3.736179e-05  3.899424e-05
## ASV0598     -2.628723e-04 -2.744536e-04 -2.865016e-04 -2.990312e-04
## ASV0429      4.256321e-04  4.452008e-04  4.656350e-04  4.869697e-04
## ASV1549      4.253180e-04  4.455854e-04  4.668182e-04  4.890626e-04
## ASV1203      3.178659e-04  3.323650e-04  3.474956e-04  3.632824e-04
## ASV4532      1.220828e-05  1.257777e-05  1.294693e-05  1.331437e-05
## ASV0274     -3.176114e-04 -3.316280e-04 -3.462141e-04 -3.613889e-04
## ASV0163     -4.572070e-04 -4.774659e-04 -4.985524e-04 -5.204939e-04
## ASV1298      1.853357e-04  1.935212e-04  2.020389e-04  2.108996e-04
## ASV9424     -3.932874e-04 -4.117216e-04 -4.310055e-04 -4.511770e-04
## ASV0412      6.013646e-04  6.288724e-04  6.575866e-04  6.875556e-04
## ASV0284      2.676289e-04  2.795353e-04  2.919330e-04  3.048386e-04
## ASV0620     -2.046167e-04 -2.145108e-04 -2.248880e-04 -2.357723e-04
## ASV0153     -4.203465e-04 -4.401772e-04 -4.609344e-04 -4.826604e-04
## ASV0498      4.858500e-05  5.150314e-05  5.461118e-05  5.792203e-05
## ASV0097      2.982269e-04  3.122440e-04  3.269129e-04  3.422635e-04
## ASV0104     -1.383852e-03 -1.447518e-03 -1.514014e-03 -1.583454e-03
## ASV1282      2.469734e-04  2.586955e-04  2.709664e-04  2.838106e-04
## ASV3883     -1.406731e-04 -1.473659e-04 -1.543754e-04 -1.617164e-04
## ASV0801      1.421749e-04  1.491635e-04  1.565029e-04  1.642109e-04
## ASV1611     -5.338371e-04 -5.587165e-04 -5.847295e-04 -6.119255e-04
## ASV0227     -1.932812e-04 -2.026007e-04 -2.123730e-04 -2.226203e-04
## ASV0833      2.092811e-04  2.194344e-04  2.300862e-04  2.412613e-04
## ASV0718      4.967855e-04  5.197811e-04  5.438105e-04  5.689176e-04
## ASV1139      1.809272e-04  1.887857e-04  1.969487e-04  2.054246e-04
## ASV0766     -1.366668e-04 -1.429055e-04 -1.494163e-04 -1.562099e-04
## ASV2091      6.592380e-04  6.886316e-04  7.192465e-04  7.511256e-04
## ASV1238     -2.973909e-05 -3.022721e-05 -3.066331e-05 -3.103954e-05
## ASV9193     -7.404959e-05 -7.836532e-05 -8.294732e-05 -8.781217e-05
## ASV0290     -5.342458e-05 -5.601452e-05 -5.873084e-05 -6.157965e-05
## ASV0231      5.263878e-04  5.505475e-04  5.757743e-04  6.021117e-04
## ASV0185      9.945718e-05  1.054233e-04  1.117819e-04  1.185606e-04
## ASV2330      1.522757e-04  1.591680e-04  1.663558e-04  1.738500e-04
## ASV3119     -1.754324e-04 -1.841271e-04 -1.932654e-04 -2.028708e-04
## ASV2368     -2.417750e-04 -2.532646e-04 -2.652985e-04 -2.779025e-04
## ASV0122     -1.883894e-04 -1.967797e-04 -2.055183e-04 -2.146174e-04
## ASV1044      3.331617e-04  3.492572e-04  3.661386e-04  3.838447e-04
## ASV0160     -4.634379e-04 -4.838620e-04 -5.051114e-04 -5.272127e-04
## ASV0326      3.030409e-04  3.171044e-04  3.318037e-04  3.471659e-04
## ASV1388      5.295947e-04  5.539726e-04  5.794334e-04  6.060218e-04
## ASV0792      6.007270e-04  6.281169e-04  6.566987e-04  6.865192e-04
## ASV0036     -3.802735e-04 -3.981321e-04 -4.168176e-04 -4.363670e-04
## ASV2125      6.185679e-04  6.469970e-04  6.766853e-04  7.076845e-04
## ASV1075      1.193064e-04  1.250159e-04  1.310002e-04  1.372728e-04
## ASV0390      1.180377e-04  1.239715e-04  1.302164e-04  1.367895e-04
## ASV3790     -4.961673e-04 -5.191872e-04 -5.432482e-04 -5.683951e-04
## ASV1535     -4.667030e-05 -4.923729e-05 -5.195485e-05 -5.483225e-05
## ASV0263      1.029431e-04  1.077204e-04  1.127130e-04  1.179300e-04
## ASV0675      8.235195e-04  8.625460e-04  9.034083e-04  9.461911e-04
## ASV3348      7.995344e-05  8.391189e-05  8.807308e-05  9.244797e-05
## ASV0058     -7.753367e-04 -8.106597e-04 -8.475206e-04 -8.859800e-04
## ASV4142      1.966308e-04  2.056634e-04  2.150949e-04  2.249415e-04
## ASV0059     -6.675505e-04 -6.978593e-04 -7.294779e-04 -7.624573e-04
## ASV0013     -1.405556e-03 -1.470247e-03 -1.537816e-03 -1.608380e-03
## ASV0033     -4.145418e-04 -4.340662e-04 -4.544996e-04 -4.758835e-04
## ASV4354     -1.812777e-04 -1.895247e-04 -1.981299e-04 -2.071075e-04
## ASV0022     -4.378612e-04 -4.584739e-04 -4.800454e-04 -5.026192e-04
## ASV0134     -1.096645e-04 -1.150524e-04 -1.207114e-04 -1.266554e-04
## ASV0415     -8.623648e-05 -8.953278e-05 -9.291585e-05 -9.638414e-05
## ASV10103    -3.041254e-04 -3.182367e-04 -3.329848e-04 -3.483967e-04
## ASV1613      4.932825e-04  5.157555e-04  5.392052e-04  5.636698e-04
## ASV0135     -2.665853e-05 -2.730788e-05 -2.793098e-05 -2.852146e-05
## ASV0469     -6.154996e-04 -6.434722e-04 -6.726550e-04 -7.030949e-04
## ASV0471      4.023499e-04  4.214754e-04  4.415010e-04  4.624676e-04
## ASV0451     -1.071309e-04 -1.123728e-04 -1.178771e-04 -1.236576e-04
## ASV0747      1.558121e-04  1.634863e-04  1.715458e-04  1.800102e-04
## ASV1314     -2.339561e-04 -2.452149e-04 -2.570199e-04 -2.693976e-04
## ASV0425     -6.947830e-04 -7.258678e-04 -7.582539e-04 -7.919879e-04
## ASV0559     -3.967529e-04 -4.145406e-04 -4.330765e-04 -4.523879e-04
## ASV0148     -4.264995e-04 -4.453897e-04 -4.650519e-04 -4.855121e-04
## ASV0129     -2.079265e-04 -2.166247e-04 -2.256318e-04 -2.349539e-04
## ASV1072      2.028289e-04  2.115835e-04  2.206770e-04  2.301194e-04
## ASV2390      1.505583e-04  1.573249e-04  1.643766e-04  1.717237e-04
## ASV0548      4.498056e-04  4.706995e-04  4.925413e-04  5.153719e-04
## ASV0168     -6.751503e-04 -7.058034e-04 -7.377815e-04 -7.711362e-04
## ASV0066     -5.057044e-04 -5.290119e-04 -5.533579e-04 -5.787855e-04
## ASV0468     -1.854349e-04 -1.939755e-04 -2.028956e-04 -2.122109e-04
## ASV0172     -1.015380e-04 -1.054483e-04 -1.094642e-04 -1.135839e-04
## ASV0236     -2.547573e-04 -2.653749e-04 -2.763647e-04 -2.877336e-04
## ASV0250      2.041806e-05  2.260796e-05  2.500773e-05  2.763595e-05
## ASV0338     -3.124551e-05 -3.190987e-05 -3.253500e-05 -3.311337e-05
## ASV0450     -3.397650e-06 -3.595988e-06 -3.807191e-06 -4.032182e-06
## ASV0377      5.536874e-04  5.792639e-04  6.059853e-04  6.338996e-04
## ASV1022      1.547064e-04  1.619303e-04  1.694851e-04  1.773853e-04
## ASV6174     -3.775130e-05 -3.942548e-05 -4.116851e-05 -4.298281e-05
## ASV0786      6.119471e-05  6.383198e-05  6.656978e-05  6.941073e-05
## ASV0053     -6.692554e-04 -7.003910e-04 -7.329405e-04 -7.669647e-04
## ASV0697     -1.925094e-04 -2.010498e-04 -2.099412e-04 -2.191955e-04
## ASV0785      4.920571e-04  5.146759e-04  5.383009e-04  5.629742e-04
## ASV1967     -3.264374e-04 -3.410534e-04 -3.562818e-04 -3.721446e-04
## ASV0385     -1.480617e-04 -1.543912e-04 -1.609613e-04 -1.677785e-04
## ASV0295      1.910312e-06  2.535063e-06  3.237958e-06  4.026932e-06
## ASV0072     -5.267336e-04 -5.503258e-04 -5.749087e-04 -6.005183e-04
## ASV0157     -2.192917e-04 -2.288742e-04 -2.388337e-04 -2.491810e-04
## ASV0501      2.483208e-04  2.603840e-04  2.730361e-04  2.863053e-04
## ASV10729    -4.075080e-04 -4.265747e-04 -4.465170e-04 -4.673735e-04
## ASV1470      1.777300e-04  1.851316e-04  1.927956e-04  2.007274e-04
## ASV0050     -1.324034e-03 -1.384553e-03 -1.447726e-03 -1.513658e-03
## ASV0411     -3.258843e-05 -3.380256e-05 -3.504690e-05 -3.632087e-05
## ASV0549      2.512570e-04  2.631778e-04  2.756644e-04  2.887439e-04
## ASV0184      1.559434e-04  1.631772e-04  1.707383e-04  1.786407e-04
## ASV0705      1.898555e-04  1.989266e-04  2.084309e-04  2.183888e-04
## ASV1715      4.713013e-04  4.931448e-04  5.159732e-04  5.398285e-04
## ASV0603      5.697823e-05  5.974009e-05  6.263808e-05  6.567912e-05
## ASV0826      1.549477e-04  1.617583e-04  1.688422e-04  1.762078e-04
## ASV0034     -5.986812e-04 -6.258354e-04 -6.541579e-04 -6.836931e-04
## ASV0838      1.302414e-04  1.363524e-04  1.427439e-04  1.494282e-04
## ASV0614     -3.418220e-04 -3.574549e-04 -3.737734e-04 -3.908048e-04
## ASV0014     -1.285822e-03 -1.344756e-03 -1.406288e-03 -1.470523e-03
## ASV0585     -7.549915e-05 -7.879325e-05 -8.221822e-05 -8.577820e-05
## ASV0016     -1.314604e-03 -1.374889e-03 -1.437834e-03 -1.503549e-03
## ASV5394     -3.349954e-04 -3.506107e-04 -3.669377e-04 -3.840071e-04
## ASV0666      2.831638e-04  2.961136e-04  3.096307e-04  3.237378e-04
## ASV2085      1.097337e-04  1.141143e-04  1.186281e-04  1.232749e-04
## ASV0003     -1.201985e-03 -1.256973e-03 -1.314377e-03 -1.374293e-03
## ASV0346     -1.965793e-05 -1.982570e-05 -1.993378e-05 -1.997369e-05
## ASV0267     -1.930099e-04 -2.016478e-04 -2.106448e-04 -2.200130e-04
## ASV0353      2.683319e-04  2.818058e-04  2.959772e-04  3.108832e-04
## ASV2419      3.384913e-04  3.538516e-04  3.698743e-04  3.865848e-04
## ASV0447      1.624101e-04  1.706144e-04  1.792499e-04  1.883405e-04
## ASV0654      5.277276e-04  5.524242e-04  5.782550e-04  6.052700e-04
## ASV0151      8.197058e-05  8.617773e-05  9.061342e-05  9.529108e-05
## ASV0065     -4.808947e-04 -5.027623e-04 -5.255785e-04 -5.493805e-04
## ASV0527      3.524523e-04  3.687015e-04  3.856755e-04  4.034042e-04
## ASV4055     -1.342389e-04 -1.407602e-04 -1.476038e-04 -1.547858e-04
## ASV0166     -3.921961e-04 -4.093303e-04 -4.271455e-04 -4.456630e-04
## ASV0417     -3.411296e-04 -3.566430e-04 -3.728285e-04 -3.897120e-04
## ASV0078     -2.689112e-04 -2.807910e-04 -2.931543e-04 -3.060168e-04
## ASV0322     -3.226522e-04 -3.367107e-04 -3.513257e-04 -3.665145e-04
## ASV0156     -4.218211e-04 -4.404994e-04 -4.599446e-04 -4.801831e-04
## ASV0648     -3.939289e-04 -4.124597e-04 -4.318509e-04 -4.521414e-04
## ASV0407      2.649206e-05  2.773834e-05  2.904554e-05  3.041704e-05
## ASV2030     -8.351892e-05 -8.713707e-05 -9.089653e-05 -9.480157e-05
## ASV0300      2.366162e-04  2.483157e-04  2.606065e-04  2.735191e-04
## ASV1150     -3.006039e-05 -3.129518e-05 -3.257066e-05 -3.388715e-05
## ASV0958      2.402179e-04  2.518263e-04  2.640025e-04  2.767750e-04
## ASV0216     -4.115250e-04 -4.300042e-04 -4.492625e-04 -4.693285e-04
## ASV0446      5.805223e-04  6.083111e-04  6.374309e-04  6.679451e-04
## ASV0367     -1.976087e-04 -2.067295e-04 -2.162582e-04 -2.262122e-04
## ASV0200     -3.626199e-04 -3.792196e-04 -3.965508e-04 -4.146432e-04
## ASV0334     -1.858228e-04 -1.935060e-04 -2.014504e-04 -2.096595e-04
## ASV1311      2.602453e-04  2.722163e-04  2.847185e-04  2.977738e-04
## ASV0458      2.778384e-04  2.905087e-04  3.037315e-04  3.175286e-04
## ASV1371      8.471005e-06  8.887787e-06  9.325559e-06  9.785400e-06
## ASV0418      3.286208e-04  3.432523e-04  3.584915e-04  3.743599e-04
## ASV0004      4.011708e-04  4.194770e-04  4.385819e-04  4.585172e-04
## ASV1943      2.938191e-04  3.070713e-04  3.208884e-04  3.352919e-04
## ASV1495     -7.820540e-05 -8.245684e-05 -8.695746e-05 -9.172303e-05
## ASV0901     -4.626568e-04 -4.844376e-04 -5.072320e-04 -5.310863e-04
## ASV0628      2.694841e-04  2.816990e-04  2.944384e-04  3.077221e-04
## ASV0400      1.110526e-04  1.162266e-04  1.216343e-04  1.272856e-04
## ASV0116     -3.507410e-04 -3.671709e-04 -3.843582e-04 -4.023366e-04
## ASV0788      2.922292e-04  3.057363e-04  3.198488e-04  3.345920e-04
## ASV0117      1.884995e-04  1.975519e-04  2.070423e-04  2.169921e-04
## ASV3137      5.305830e-05  5.554277e-05  5.814208e-05  6.086143e-05
## ASV0001      4.824969e-04  5.041161e-04  5.266439e-04  5.501135e-04
## ASV1651      3.175924e-04  3.316136e-04  3.462045e-04  3.613839e-04
## ASV1692      3.465384e-04  3.629718e-04  3.801802e-04  3.981997e-04
## ASV0660      1.981754e-04  2.068969e-04  2.159661e-04  2.253933e-04
## ASV0508      2.269752e-05  2.351181e-05  2.434186e-05  2.518659e-05
## ASV1660     -1.432588e-04 -1.501915e-04 -1.574629e-04 -1.650898e-04
## ASV0233      7.669201e-05  8.028145e-05  8.403680e-05  8.796560e-05
## ASV1343     -3.497218e-04 -3.660726e-04 -3.831737e-04 -4.010582e-04
## ASV0209      3.235435e-04  3.381134e-04  3.533015e-04  3.691307e-04
## ASV0193     -4.058584e-04 -4.236597e-04 -4.421763e-04 -4.614312e-04
## ASV0357     -2.658470e-05 -2.755307e-05 -2.854033e-05 -2.954496e-05
## ASV0198      9.373993e-05  9.828800e-05  1.030581e-04  1.080610e-04
## ASV0007      4.573741e-04  4.778669e-04  4.992212e-04  5.214683e-04
## ASV1772     -4.577581e-05 -4.778615e-05 -4.987616e-05 -5.204813e-05
## ASV0009      4.313081e-04  4.505950e-04  4.706891e-04  4.916195e-04
## ASV0006      1.738356e-04  1.813151e-04  1.890808e-04  1.971405e-04
## ASV0011     -4.881620e-04 -5.110373e-04 -5.349657e-04 -5.599939e-04
## ASV0015      3.369550e-04  3.523377e-04  3.683918e-04  3.851438e-04
## ASV0017      3.567085e-04  3.729632e-04  3.899248e-04  4.076212e-04
## ASV0235     -2.873946e-04 -3.009429e-04 -3.151209e-04 -3.299567e-04
## ASV0382      5.560404e-05  5.888330e-05  6.237175e-05  6.608341e-05
## ASV2357      4.334955e-04  4.536987e-04  4.748232e-04  4.969091e-04
## ASV0567     -3.109445e-04 -3.250264e-04 -3.397149e-04 -3.550338e-04
## ASV0165      3.479018e-04  3.641626e-04  3.811685e-04  3.989522e-04
## ASV0005      6.889446e-04  7.203235e-04  7.530676e-04  7.872307e-04
## ASV0384     -3.064535e-05 -3.164892e-05 -3.265808e-05 -3.366929e-05
## ASV0002      1.459619e-04  1.528377e-04  1.600333e-04  1.675628e-04
## ASV3017      4.021746e-04  4.203896e-04  4.393872e-04  4.591973e-04
## ASV0091      1.558034e-04  1.631764e-04  1.708959e-04  1.789778e-04
## ASV0186     -4.165192e-04 -4.359019e-04 -4.561651e-04 -4.773467e-04
## ASV0370      4.577800e-05  4.814273e-05  5.063687e-05  5.326806e-05
## ASV0018      7.177369e-04  7.504938e-04  7.846821e-04  8.203589e-04
## ASV1377      6.280099e-04  6.566318e-04  6.864979e-04  7.176570e-04
## ASV0019      7.188272e-04  7.516476e-04  7.859034e-04  8.216520e-04
## ASV0023      4.937568e-05  5.113232e-05  5.292117e-05  5.473962e-05
## ASV2194      2.270445e-04  2.373811e-04  2.481706e-04  2.594314e-04
## ASV1155     -2.663449e-05 -2.763896e-05 -2.866709e-05 -2.971789e-05
## ASV0510     -2.582121e-04 -2.692649e-04 -2.807361e-04 -2.926368e-04
## ASV2371     -2.557663e-04 -2.669684e-04 -2.786166e-04 -2.907249e-04
## ASV0024      1.468492e-05  1.483299e-05  1.494068e-05  1.500231e-05
## ASV2452      3.359260e-04  3.509455e-04  3.665925e-04  3.828895e-04
## ASV2332      1.245954e-05  1.333736e-05  1.428522e-05  1.530918e-05
## ASV2591      1.843720e-05  1.990483e-05  2.149342e-05  2.321281e-05
## ASV0521      4.672906e-04  4.894710e-04  5.126976e-04  5.370190e-04
## ASV5542      1.451681e-04  1.522001e-04  1.595756e-04  1.673114e-04
## ASV0336     -2.065031e-04 -2.155397e-04 -2.249390e-04 -2.347128e-04
## ASV10102     3.239218e-04  3.391925e-04  3.551749e-04  3.719013e-04
## ASV16823    -2.489880e-04 -2.598889e-04 -2.712240e-04 -2.830070e-04
## ASV3104      2.489646e-04  2.598635e-04  2.711964e-04  2.829768e-04
## ASV0781      1.243246e-04  1.301203e-04  1.361800e-04  1.425152e-04
## ASV10899     1.197733e-04  1.258561e-04  1.322613e-04  1.390067e-04
## ASV11222    -2.489496e-04 -2.598472e-04 -2.711787e-04 -2.829578e-04
## ASV11327    -2.489262e-04 -2.598218e-04 -2.711511e-04 -2.829276e-04
## ASV12458    -2.489029e-04 -2.597963e-04 -2.711234e-04 -2.828975e-04
## ASV1636     -2.038597e-04 -2.127755e-04 -2.220453e-04 -2.316799e-04
## ASV1890     -2.486244e-04 -2.596261e-04 -2.710775e-04 -2.829939e-04
## ASV2898      5.429241e-04  5.676755e-04  5.935040e-04  6.204518e-04
## ASV8328     -3.813357e-05 -3.916951e-05 -4.018586e-05 -4.117595e-05
## ASV0709     -4.444651e-04 -4.648177e-04 -4.860641e-04 -5.082400e-04
## ASV0856      7.265954e-05  7.628264e-05  8.009233e-05  8.409860e-05
## ASV0909     -1.843504e-04 -1.920706e-04 -2.000638e-04 -2.083348e-04
## ASV0937     -3.454494e-04 -3.614187e-04 -3.781052e-04 -3.955393e-04
## ASV11390    -2.488536e-04 -2.597428e-04 -2.710652e-04 -2.828343e-04
## ASV11966     1.306790e-04  1.370992e-04  1.438413e-04  1.509220e-04
## ASV12990     7.069641e-05  7.410694e-05  7.768235e-05  8.143049e-05
## ASV14797     2.621208e-04  2.740253e-04  2.864433e-04  2.993945e-04
## ASV14904    -2.488481e-04 -2.597368e-04 -2.710588e-04 -2.828276e-04
## ASV15304     7.056423e-05  7.428546e-05  7.821480e-05  8.236458e-05
## ASV16696    -2.488293e-04 -2.597165e-04 -2.710368e-04 -2.828036e-04
## ASV1690      1.327576e-04  1.393651e-04  1.463104e-04  1.536113e-04
## ASV2029      6.961633e-04  7.280116e-04  7.612566e-04  7.959539e-04
## ASV2834      3.738333e-04  3.911370e-04  4.092188e-04  4.281117e-04
## ASV4003      1.104331e-04  1.161803e-04  1.222436e-04  1.286415e-04
## ASV4064      2.588094e-04  2.708147e-04  2.833614e-04  2.964725e-04
## ASV4294      9.469564e-05  9.964084e-05  1.048601e-04  1.103698e-04
## ASV4609     -1.001425e-05 -1.033190e-05 -1.065092e-05 -1.097028e-05
## ASV6283     -2.488277e-04 -2.597150e-04 -2.710355e-04 -2.828027e-04
## ASV6491     -2.488043e-04 -2.596896e-04 -2.710079e-04 -2.827726e-04
## ASV7453      1.024815e-04  1.077298e-04  1.132592e-04  1.190854e-04
## ASV7959      2.243823e-05  2.398562e-05  2.564808e-05  2.743439e-05
## ASV8219      2.487889e-04  2.596729e-04  2.709899e-04  2.827532e-04
## ASV8547     -2.487655e-04 -2.596475e-04 -2.709622e-04 -2.827231e-04
## ASV9319      1.730863e-04  1.813607e-04  1.900305e-04  1.991145e-04
## ASV9382     -2.487518e-04 -2.596326e-04 -2.709461e-04 -2.827057e-04
## ASV11516    -2.487285e-04 -2.596072e-04 -2.709185e-04 -2.826756e-04
## ASV14377    -2.487052e-04 -2.595819e-04 -2.708909e-04 -2.826456e-04
## ASV1867      3.710602e-04  3.884553e-04  4.066526e-04  4.256880e-04
## ASV1895     -8.427298e-05 -8.790195e-05 -9.167043e-05 -9.558239e-05
## ASV3168      1.585961e-04  1.658619e-04  1.734458e-04  1.813603e-04
## ASV4449      3.110433e-04  3.248971e-04  3.393256e-04  3.543490e-04
## ASV6596      1.840113e-04  1.930898e-04  2.026284e-04  2.126513e-04
## ASV7492     -9.059479e-05 -9.413134e-05 -9.776812e-05 -1.015043e-04
## ASV9854     -1.265257e-04 -1.319036e-04 -1.374810e-04 -1.432628e-04
## ASV6296      2.486574e-04  2.595300e-04  2.708346e-04  2.825847e-04
## ASV4201      8.670085e-05  9.144728e-05  9.647341e-05  1.017969e-04
## ASV0552      6.238277e-04  6.532262e-04  6.839930e-04  7.161900e-04
## ASV3671     -4.829533e-05 -5.000012e-05 -5.173439e-05 -5.349536e-05
## ASV3529     -5.191602e-05 -5.368419e-05 -5.547548e-05 -5.728607e-05
## ASV1060      1.548872e-04  1.621123e-04  1.696677e-04  1.775678e-04
## ASV0239     -3.493186e-04 -3.647878e-04 -3.808867e-04 -3.976360e-04
## ASV5711     -3.210140e-04 -3.353154e-04 -3.502103e-04 -3.657196e-04
## ASV4152     -4.238493e-04 -4.429867e-04 -4.629413e-04 -4.837438e-04
## ASV1461      3.810803e-04  3.981696e-04  4.159759e-04  4.345249e-04
## ASV2877      3.095718e-04  3.236638e-04  3.383664e-04  3.537033e-04
## ASV0012      2.323293e-04  2.432705e-04  2.547199e-04  2.667005e-04
## ASV9823      7.179190e-05  7.442055e-05  7.711095e-05  7.986155e-05
## ASV0008      2.535659e-04  2.654300e-04  2.778386e-04  2.908156e-04
## ASV7832     -2.620633e-04 -2.738691e-04 -2.861772e-04 -2.990066e-04
## ASV1915      2.308844e-05  2.446572e-05  2.593200e-05  2.749327e-05
## ASV0055      1.793200e-04  1.874703e-04  1.959720e-04  2.048386e-04
## ASV0032      4.398538e-04  4.598889e-04  4.807955e-04  5.026078e-04
## ASV2977     -3.557436e-04 -3.717391e-04 -3.884111e-04 -4.057845e-04
## ASV0466      3.602178e-04  3.762024e-04  3.928428e-04  4.101613e-04
## ASV3866      3.858156e-04  4.038269e-04  4.226616e-04  4.423555e-04
## ASV0040      5.103933e-04  5.342438e-04  5.591864e-04  5.852689e-04
## ASV0496     -3.134804e-05 -3.338178e-05 -3.556078e-05 -3.789608e-05
## ASV0052      6.241660e-04  6.528314e-04  6.827646e-04  7.140171e-04
## ASV3828     -3.821594e-04 -3.994710e-04 -4.175282e-04 -4.363599e-04
## ASV1930      2.420052e-04  2.533298e-04  2.651733e-04  2.775582e-04
## ASV2126      3.887583e-04  4.066155e-04  4.252621e-04  4.447302e-04
## ASV0793      2.334439e-04  2.446323e-04  2.563582e-04  2.686471e-04
## ASV0299     -1.637442e-04 -1.708841e-04 -1.783045e-04 -1.860137e-04
## ASV0208      3.690601e-04  3.867387e-04  4.052654e-04  4.246808e-04
## ASV0511     -1.972039e-04 -2.057475e-04 -2.146213e-04 -2.238343e-04
## ASV1123     -2.580654e-04 -2.694322e-04 -2.812575e-04 -2.935558e-04
## ASV0099     -1.378206e-04 -1.438443e-04 -1.501066e-04 -1.566149e-04
## ASV0752     -3.233737e-05 -3.417652e-05 -3.612898e-05 -3.820221e-05
## ASV0883      4.495426e-06  4.862017e-06  5.259273e-06  5.689714e-06
## ASV0683      3.267015e-04  3.422110e-04  3.584530e-04  3.754618e-04
## ASV4117     -3.830684e-04 -4.003668e-04 -4.184044e-04 -4.372091e-04
## ASV2172      1.445232e-04  1.512435e-04  1.582684e-04  1.656111e-04
## ASV0330     -2.576702e-04 -2.694639e-04 -2.817777e-04 -2.946331e-04
## ASV0728      2.479316e-04  2.596274e-04  2.718680e-04  2.846778e-04
## ASV0499      4.931941e-04  5.166160e-04  5.411467e-04  5.668386e-04
## ASV0120     -5.437740e-04 -5.688597e-04 -5.950638e-04 -6.224327e-04
## ASV1446      4.275873e-05  4.429471e-05  4.585922e-05  4.744984e-05
## ASV17171    -3.644388e-04 -3.809707e-04 -3.982161e-04 -4.162025e-04
## ASV0533      1.056730e-04  1.107874e-04  1.161525e-04  1.217808e-04
## ASV2495     -1.491936e-04 -1.562159e-04 -1.635666e-04 -1.712608e-04
## ASV5582      1.276308e-04  1.331491e-04  1.388797e-04  1.448285e-04
## ASV1488      1.333961e-04  1.403292e-04  1.476348e-04  1.553329e-04
## ASV0682      3.455226e-04  3.620262e-04  3.793197e-04  3.974411e-04
## ASV0068     -1.911590e-05 -2.025090e-05 -2.145875e-05 -2.274433e-05
## ASV1987     -1.882196e-04 -1.974971e-04 -2.072435e-04 -2.174831e-04
## ASV0035      6.483132e-05  6.731803e-05  6.986816e-05  7.247986e-05
## ASV7192     -2.443153e-04 -2.551184e-04 -2.663613e-04 -2.780585e-04
## ASV0873      3.521480e-05  3.648937e-05  3.778991e-05  3.911488e-05
## ASV4749      1.971838e-05  2.006654e-05  2.037770e-05  2.064544e-05
## ASV2174      2.213946e-04  2.306637e-04  2.402683e-04  2.502162e-04
## ASV1476     -2.013612e-04 -2.105623e-04 -2.201676e-04 -2.301936e-04
## ASV0740     -4.977608e-04 -5.212418e-04 -5.458188e-04 -5.715418e-04
## ASV0170      1.046451e-04  1.094391e-04  1.144447e-04  1.196706e-04
## ASV2466     -4.496132e-04 -4.702528e-04 -4.918061e-04 -5.143108e-04
## ASV1709      3.470837e-04  3.628095e-04  3.792117e-04  3.963162e-04
## ASV6170     -2.888841e-04 -3.009883e-04 -3.135363e-04 -3.265401e-04
## ASV3673      3.476902e-04  3.630535e-04  3.790502e-04  3.957034e-04
## ASV1745      1.618262e-05  1.646334e-05  1.672046e-05  1.695056e-05
## ASV0380     -2.261532e-04 -2.352475e-04 -2.446408e-04 -2.543377e-04
## ASV0426     -7.200233e-05 -7.493344e-05 -7.796303e-05 -8.109268e-05
## ASV0202     -7.258492e-05 -7.504420e-05 -7.753114e-05 -8.003942e-05
## ASV6350     -2.875074e-04 -2.995634e-04 -3.120627e-04 -3.250173e-04
## ASV0713     -2.170390e-04 -2.271082e-04 -2.376330e-04 -2.486330e-04
## ASV1822      4.827558e-05  5.090267e-05  5.367971e-05  5.661540e-05
## ASV4569      3.418915e-04  3.572616e-04  3.732868e-04  3.899923e-04
## ASV0030     -8.020190e-05 -8.424616e-05 -8.849904e-05 -9.297130e-05
## ASV0331      1.435893e-04  1.506722e-04  1.581130e-04  1.659305e-04
## ASV2981      3.541597e-04  3.710301e-04  3.886985e-04  4.072016e-04
## ASV0828     -2.366434e-04 -2.480745e-04 -2.600610e-04 -2.726297e-04
## ASV2440      5.544777e-04  5.806541e-04  6.080524e-04  6.367279e-04
## ASV3006     -2.298774e-04 -2.391682e-04 -2.487694e-04 -2.586864e-04
## ASV3875     -2.298577e-04 -2.391469e-04 -2.487464e-04 -2.586615e-04
## ASV4511      1.384815e-04  1.451316e-04  1.521027e-04  1.594107e-04
## ASV4700     -2.298382e-04 -2.391258e-04 -2.487235e-04 -2.586369e-04
## ASV5804     -2.298185e-04 -2.391045e-04 -2.487005e-04 -2.586120e-04
## ASV6826      2.561695e-04  2.683759e-04  2.811627e-04  2.945573e-04
## ASV7280      2.230751e-04  2.340892e-04  2.456543e-04  2.577978e-04
## ASV7535     -2.298099e-04 -2.390954e-04 -2.486909e-04 -2.586019e-04
## ASV0651     -2.470722e-04 -2.580825e-04 -2.695470e-04 -2.814810e-04
## ASV0913      3.338902e-04  3.496434e-04  3.661327e-04  3.833919e-04
## ASV10832    -2.297913e-04 -2.390753e-04 -2.486692e-04 -2.585784e-04
## ASV1117     -4.729409e-04 -4.942772e-04 -5.165281e-04 -5.397290e-04
## ASV11329     1.230526e-04  1.297974e-04  1.369346e-04  1.444878e-04
## ASV13209    -5.652150e-06 -4.856266e-06 -3.940995e-06 -2.895465e-06
## ASV1345      6.778148e-05  7.144824e-05  7.532018e-05  7.940853e-05
## ASV1719     -2.297624e-04 -2.390442e-04 -2.486358e-04 -2.585427e-04
## ASV1886      2.690605e-04  2.810777e-04  2.936020e-04  3.066528e-04
## ASV2158     -5.374066e-05 -5.510305e-05 -5.643809e-05 -5.773850e-05
## ASV2189      2.918485e-04  3.052574e-04  3.192622e-04  3.338878e-04
## ASV2257      2.156834e-04  2.253833e-04  2.354992e-04  2.460477e-04
## ASV2283      2.297190e-04  2.389973e-04  2.485850e-04  2.584877e-04
## ASV2328      2.296993e-04  2.389760e-04  2.485620e-04  2.584629e-04
## ASV2434     -3.487162e-04 -3.640088e-04 -3.799241e-04 -3.964840e-04
## ASV2648      2.296554e-04  2.389284e-04  2.485104e-04  2.584069e-04
## ASV2698      3.434765e-04  3.594361e-04  3.761215e-04  3.935644e-04
## ASV2775      4.084512e-04  4.262724e-04  4.448028e-04  4.640653e-04
## ASV3171      2.296132e-04  2.388826e-04  2.484607e-04  2.583530e-04
## ASV3227      3.026146e-04  3.157190e-04  3.293351e-04  3.434783e-04
## ASV3397      2.703538e-05  2.871899e-05  3.051056e-05  3.241660e-05
## ASV3444      3.358317e-04  3.503573e-04  3.654569e-04  3.811495e-04
## ASV3556      2.295614e-04  2.388264e-04  2.483998e-04  2.582871e-04
## ASV3606     -2.295418e-04 -2.388051e-04 -2.483769e-04 -2.582623e-04
## ASV4190      3.035329e-04  3.175953e-04  3.322945e-04  3.476585e-04
## ASV4197      3.473082e-04  3.624163e-04  3.781257e-04  3.944561e-04
## ASV4722      3.151486e-04  3.294632e-04  3.444003e-04  3.599849e-04
## ASV4765      8.465687e-05  8.893779e-05  9.343596e-05  9.816175e-05
## ASV4809      2.294917e-04  2.387508e-04  2.483179e-04  2.581984e-04
## ASV4846      2.265785e-04  2.372369e-04  2.483870e-04  2.600500e-04
## ASV4903     -5.381773e-05 -5.520243e-05 -5.656228e-05 -5.789020e-05
## ASV4944     -2.294734e-04 -2.387312e-04 -2.482969e-04 -2.581760e-04
## ASV5151     -9.928847e-05 -1.048849e-04 -1.108160e-04 -1.171025e-04
## ASV5413     -2.294601e-04 -2.387170e-04 -2.482818e-04 -2.581598e-04
## ASV5537     -2.294404e-04 -2.386957e-04 -2.482588e-04 -2.581351e-04
## ASV5688      2.294208e-04  2.386745e-04  2.482359e-04  2.581103e-04
## ASV5752      1.225627e-04  1.288480e-04  1.354631e-04  1.424250e-04
## ASV6122     -2.294073e-04 -2.386601e-04 -2.482204e-04 -2.580938e-04
## ASV6135      2.293877e-04  2.386389e-04  2.481975e-04  2.580690e-04
## ASV6188     -2.293681e-04 -2.386177e-04 -2.481746e-04 -2.580443e-04
## ASV6216      3.466546e-04  3.617102e-04  3.773636e-04  3.936344e-04
## ASV6242      2.293256e-04  2.385716e-04  2.481247e-04  2.579902e-04
## ASV6383      2.293060e-04  2.385504e-04  2.481018e-04  2.579655e-04
## ASV6781      2.292864e-04  2.385292e-04  2.480789e-04  2.579408e-04
## ASV6799     -2.292668e-04 -2.385080e-04 -2.480560e-04 -2.579160e-04
## ASV7374     -2.292472e-04 -2.384868e-04 -2.480331e-04 -2.578913e-04
## ASV7539     -2.292276e-04 -2.384656e-04 -2.480102e-04 -2.578666e-04
## ASV8591     -2.292080e-04 -2.384445e-04 -2.479873e-04 -2.578419e-04
## ASV8637      2.291884e-04  2.384233e-04  2.479644e-04  2.578172e-04
## ASV12796    -2.291688e-04 -2.384021e-04 -2.479416e-04 -2.577925e-04
## ASV1934      2.749162e-04  2.877096e-04  3.010850e-04  3.150678e-04
## ASV22549     2.300168e-05  2.511207e-05  2.740071e-05  2.988106e-05
## ASV29857    -2.291510e-04 -2.383830e-04 -2.479211e-04 -2.577706e-04
## ASV3215      3.357918e-04  3.516713e-04  3.682974e-04  3.857048e-04
## ASV3236     -2.291300e-04 -2.383603e-04 -2.478965e-04 -2.577440e-04
## ASV3954     -2.291104e-04 -2.383391e-04 -2.478737e-04 -2.577193e-04
## ASV4850      2.290908e-04  2.383179e-04  2.478508e-04  2.576947e-04
## ASV5225      2.290713e-04  2.382968e-04  2.478279e-04  2.576700e-04
## ASV5532     -2.290517e-04 -2.382756e-04 -2.478051e-04 -2.576453e-04
## ASV7258      3.595667e-05  3.888388e-05  4.204723e-05  4.546473e-05
## ASV9474     -1.252952e-04 -1.297414e-04 -1.342795e-04 -1.389060e-04
## ASV11857    -2.290273e-04 -2.382495e-04 -2.477773e-04 -2.576157e-04
## ASV1202     -2.290077e-04 -2.382284e-04 -2.477544e-04 -2.575910e-04
## ASV14742     1.735315e-04  1.823633e-04  1.916603e-04  2.014476e-04
## ASV16652     9.139859e-05  9.608891e-05  1.010227e-04  1.062119e-04
## ASV2019      3.446529e-04  3.598308e-04  3.756290e-04  3.920694e-04
## ASV2410     -3.240529e-04 -3.388766e-04 -3.543565e-04 -3.705201e-04
## ASV2718      3.489805e-04  3.657461e-04  3.833163e-04  4.017290e-04
## ASV2738      3.881580e-04  4.049953e-04  4.224945e-04  4.406760e-04
## ASV2876      2.289645e-04  2.381818e-04  2.477041e-04  2.575367e-04
## ASV3177      2.289450e-04  2.381606e-04  2.476812e-04  2.575120e-04
## ASV4367      2.289254e-04  2.381395e-04  2.476584e-04  2.574874e-04
## ASV4635      8.901307e-05  9.423741e-05  9.978466e-05  1.056747e-04
## ASV4896      2.703586e-05  2.960068e-05  3.238992e-05  3.542148e-05
## ASV4907      1.824183e-04  1.919189e-04  2.019343e-04  2.124929e-04
## ASV5230     -2.289285e-04 -2.381435e-04 -2.476635e-04 -2.574937e-04
## ASV6509     -2.289089e-04 -2.381223e-04 -2.476406e-04 -2.574691e-04
## ASV7376     -2.288894e-04 -2.381012e-04 -2.476178e-04 -2.574444e-04
## ASV8163     -2.288698e-04 -2.380801e-04 -2.475950e-04 -2.574198e-04
## ASV8195     -2.288503e-04 -2.380590e-04 -2.475722e-04 -2.573952e-04
## ASV8923      1.506469e-04  1.582651e-04  1.662775e-04  1.747046e-04
## ASV9666     -2.014969e-04 -2.094159e-04 -2.175792e-04 -2.259893e-04
## ASV1482      2.219380e-04  2.325532e-04  2.436741e-04  2.553240e-04
## ASV2726      2.881922e-04  3.020721e-04  3.166206e-04  3.318691e-04
## ASV3281     -2.288313e-04 -2.380388e-04 -2.475507e-04 -2.573724e-04
## ASV4235     -2.288118e-04 -2.380176e-04 -2.475279e-04 -2.573478e-04
## ASV4808      3.491885e-04  3.644978e-04  3.804288e-04  3.970033e-04
## ASV4861     -3.481383e-04 -3.633826e-04 -3.792459e-04 -3.957503e-04
## ASV5276      3.451381e-04  3.602366e-04  3.759437e-04  3.922800e-04
## ASV5837      2.993012e-04  3.133085e-04  3.279625e-04  3.432927e-04
## ASV7098      3.054232e-04  3.196440e-04  3.345153e-04  3.500660e-04
## ASV8451     -2.287180e-04 -2.379156e-04 -2.474170e-04 -2.572273e-04
## ASV8694     -2.286984e-04 -2.378945e-04 -2.473942e-04 -2.572027e-04
## ASV0905     -1.294647e-04 -1.356413e-04 -1.421037e-04 -1.488635e-04
## ASV2900      2.830736e-04  2.948702e-04  3.070946e-04  3.197575e-04
## ASV3963     -2.220212e-04 -2.309011e-04 -2.400698e-04 -2.495318e-04
## ASV0041     -2.656413e-04 -2.784507e-04 -2.918791e-04 -3.059562e-04
## ASV1865      2.699283e-04  2.834101e-04  2.975805e-04  3.124749e-04
## ASV1140      2.200143e-04  2.306841e-04  2.418688e-04  2.535922e-04
## ASV1179      3.131487e-04  3.279203e-04  3.433795e-04  3.595573e-04
## ASV0279      4.361523e-04  4.558890e-04  4.764786e-04  4.979547e-04
## ASV0043     -4.092359e-05 -4.342145e-05 -4.608832e-05 -4.893664e-05
## ASV2097     -2.402758e-04 -2.506858e-04 -2.615098e-04 -2.727619e-04
## ASV0309     -1.209766e-04 -1.261894e-04 -1.316037e-04 -1.372251e-04
## ASV0607      5.344870e-04  5.596199e-04  5.859178e-04  6.134332e-04
## ASV0025     -5.663445e-04 -5.931446e-04 -6.211988e-04 -6.505641e-04
## ASV2284     -8.581178e-05 -8.888286e-05 -9.201814e-05 -9.521481e-05
## ASV0556      9.902790e-05  1.042234e-04  1.097051e-04  1.154892e-04
## ASV5040      1.900219e-04  1.974052e-04  2.050084e-04  2.128328e-04
## ASV2924     -2.043268e-04 -2.124099e-04 -2.207480e-04 -2.293442e-04
## ASV1331      6.835520e-04  7.149962e-04  7.478407e-04  7.821439e-04
## ASV0506     -3.079234e-04 -3.212575e-04 -3.351117e-04 -3.495016e-04
## ASV1514      5.136032e-04  5.373608e-04  5.621830e-04  5.881143e-04
## ASV2144      4.310923e-04  4.508338e-04  4.714465e-04  4.929664e-04
## ASV2265      5.733733e-04  5.998620e-04  6.275376e-04  6.564499e-04
## ASV5156      1.199746e-04  1.247116e-04  1.295947e-04  1.346252e-04
## ASV5534      9.561101e-05  9.910302e-05  1.026748e-04  1.063238e-04
## ASV5747     -2.348735e-05 -2.557272e-05 -2.783387e-05 -3.028441e-05
## ASV6657      2.564212e-04  2.677255e-04  2.794917e-04  2.917360e-04
## ASV0658     -2.876969e-04 -3.001411e-04 -3.130703e-04 -3.264990e-04
## ASV0716      7.326951e-05  7.648885e-05  7.983751e-05  8.331961e-05
## ASV1657      1.207930e-04  1.254902e-04  1.303246e-04  1.352963e-04
## ASV1885     -1.096600e-05 -1.239645e-05 -1.396708e-05 -1.568951e-05
## ASV2333      6.279026e-04  6.563430e-04  6.860086e-04  7.169468e-04
## ASV3375      2.298426e-04  2.397111e-04  2.499600e-04  2.606009e-04
## ASV4317      2.446792e-04  2.560008e-04  2.678353e-04  2.802052e-04
## ASV9599     -2.356536e-05 -2.565733e-05 -2.792561e-05 -3.038383e-05
## ASV0175     -8.443853e-04 -8.825990e-04 -9.224502e-04 -9.640007e-04
## ASV1032      2.470717e-04  2.576513e-04  2.686351e-04  2.800344e-04
## ASV1235      4.305620e-06  3.855470e-06  3.330759e-06  2.724142e-06
## ASV1262      7.442019e-04  7.781104e-04  8.134960e-04  8.504170e-04
## ASV1320      1.862647e-04  1.956888e-04  2.056063e-04  2.160440e-04
## ASV13797     2.731903e-04  2.853231e-04  2.979606e-04  3.111213e-04
## ASV1491      1.464650e-04  1.541025e-04  1.621531e-04  1.706395e-04
## ASV15014    -2.359564e-05 -2.568982e-05 -2.796043e-05 -3.042109e-05
## ASV1510      2.296707e-04  2.409405e-04  2.527678e-04  2.651798e-04
## ASV1551     -9.170537e-05 -9.578840e-05 -1.000410e-04 -1.044691e-04
## ASV1919     -9.846872e-06 -9.304360e-06 -8.655336e-06 -7.889122e-06
## ASV2114      1.329041e-04  1.384430e-04  1.441834e-04  1.501308e-04
## ASV21486    -2.358194e-05 -2.567429e-05 -2.794283e-05 -3.040117e-05
## ASV2448      3.785723e-04  3.954027e-04  4.129317e-04  4.311841e-04
## ASV2589      1.787090e-04  1.863676e-04  1.943205e-04  2.025764e-04
## ASV2608      3.022261e-04  3.158019e-04  3.299549e-04  3.447071e-04
## ASV2786      2.424049e-04  2.534091e-04  2.648937e-04  2.768786e-04
## ASV2827      3.178676e-04  3.322379e-04  3.472255e-04  3.628544e-04
## ASV2872      2.560333e-04  2.670314e-04  2.784508e-04  2.903034e-04
## ASV3125      3.045631e-04  3.178384e-04  3.316420e-04  3.459908e-04
## ASV3247      3.322099e-04  3.467926e-04  3.619633e-04  3.777416e-04
## ASV3451     -2.369809e-05 -2.580075e-05 -2.808047e-05 -3.055091e-05
## ASV3465     -4.338059e-05 -4.633593e-05 -4.950300e-05 -5.289682e-05
## ASV3809      1.905536e-04  1.986386e-04  2.070251e-04  2.157213e-04
## ASV4006      4.141157e-04  4.322694e-04  4.511509e-04  4.707839e-04
## ASV4046      2.934158e-04  3.061797e-04  3.194493e-04  3.332406e-04
## ASV4938     -2.562744e-05 -2.782201e-05 -3.019797e-05 -3.276918e-05
## ASV5435     -2.373133e-05 -2.583634e-05 -2.811855e-05 -3.059160e-05
## ASV5605      1.184973e-04  1.231041e-04  1.278452e-04  1.327209e-04
## ASV5635     -2.373547e-05 -2.584056e-05 -2.812281e-05 -3.059587e-05
## ASV5743      3.725449e-04  3.891200e-04  4.063855e-04  4.243666e-04
## ASV6627     -2.375481e-05 -2.586147e-05 -2.814540e-05 -3.062026e-05
## ASV6785     -2.375047e-05 -2.585655e-05 -2.813981e-05 -3.061391e-05
## ASV7368      4.079722e-04  4.267527e-04  4.463723e-04  4.668664e-04
## ASV9118      1.115997e-04  1.159857e-04  1.205061e-04  1.251619e-04
## ASV9135      8.596569e-05  8.902276e-05  9.214157e-05  9.531905e-05
## ASV9435      1.933015e-04  2.012139e-04  2.093935e-04  2.178444e-04
## ASV9671     -2.378552e-05 -2.589434e-05 -2.818054e-05 -3.065777e-05
## ASV0387     -4.117048e-04 -4.297162e-04 -4.484469e-04 -4.679201e-04
## ASV0454     -4.103671e-04 -4.285430e-04 -4.474641e-04 -4.671557e-04
## ASV0751     -2.672094e-04 -2.787556e-04 -2.907502e-04 -3.032065e-04
## ASV1081      1.114117e-04  1.165923e-04  1.220054e-04  1.276608e-04
## ASV1332      2.249811e-04  2.351193e-04  2.456873e-04  2.567009e-04
## ASV2659      3.605717e-04  3.773475e-04  3.948798e-04  4.131999e-04
## ASV2979      3.717052e-04  3.878666e-04  4.046638e-04  4.221161e-04
## ASV4184      1.487202e-04  1.544726e-04  1.603879e-04  1.664654e-04
## ASV6198      1.301640e-04  1.357428e-04  1.415377e-04  1.475555e-04
## ASV7454      2.416840e-04  2.521973e-04  2.631245e-04  2.744783e-04
## ASV8198      9.468017e-05  9.800238e-05  1.013855e-04  1.048252e-04
## ASV0855      5.430924e-04  5.681262e-04  5.942772e-04  6.215922e-04
## ASV10092     2.287470e-04  2.387247e-04  2.491019e-04  2.598920e-04
## ASV1532      3.010664e-04  3.155226e-04  3.306765e-04  3.465620e-04
## ASV2553      7.208527e-04  7.540301e-04  7.886840e-04  8.248758e-04
## ASV2741      2.933211e-04  3.074908e-04  3.223468e-04  3.379216e-04
## ASV4095      1.621038e-04  1.704299e-04  1.791969e-04  1.884282e-04
## ASV5295      2.084588e-04  2.170522e-04  2.259429e-04  2.351364e-04
## ASV5787     -2.386528e-05 -2.598032e-05 -2.827314e-05 -3.075743e-05
## ASV9455      2.785676e-04  2.908115e-04  3.035532e-04  3.168099e-04
## ASV10879     2.899946e-04  3.030742e-04  3.167164e-04  3.309433e-04
## ASV3997      2.044812e-04  2.144322e-04  2.248683e-04  2.358122e-04
## ASV6760      5.419973e-05  5.560161e-05  5.697483e-05  5.831119e-05
## ASV6990      2.085917e-04  2.175392e-04  2.268316e-04  2.364794e-04
## ASV9560      1.289413e-04  1.342064e-04  1.396523e-04  1.452829e-04
## ASV0220      1.196490e-04  1.252318e-04  1.310690e-04  1.371716e-04
## ASV2518      2.847141e-04  2.979991e-04  3.118912e-04  3.264168e-04
## ASV3615      4.434559e-04  4.635456e-04  4.845029e-04  5.063617e-04
## ASV0075      1.024612e-04  1.069731e-04  1.116685e-04  1.165535e-04
## ASV8070      5.070171e-05  5.206832e-05  5.341588e-05  5.473751e-05
## ASV1658      2.094355e-04  2.186272e-04  2.281916e-04  2.381415e-04
## ASV0773      3.443482e-04  3.597011e-04  3.756960e-04  3.923565e-04
## ASV0799      1.240506e-05  1.302854e-05  1.368434e-05  1.437418e-05
## ASV1839     -7.020779e-05 -7.309071e-05 -7.606958e-05 -7.914542e-05
## ASV0265      3.344006e-04  3.508536e-04  3.681320e-04  3.862777e-04
## ASV3741      1.282228e-04  1.338811e-04  1.397685e-04  1.458922e-04
## ASV0847      4.602751e-04  4.813758e-04  5.034068e-04  5.264058e-04
## ASV1026      4.923593e-04  5.147843e-04  5.381841e-04  5.625970e-04
## ASV1222     -1.487758e-04 -1.546417e-04 -1.606892e-04 -1.669203e-04
## ASV0729      6.948870e-05  7.272537e-05  7.610935e-05  7.964704e-05
## ASV0143     -3.739110e-04 -3.903585e-04 -4.074713e-04 -4.252716e-04
## ASV1328      1.115811e-04  1.171211e-04  1.229437e-04  1.290637e-04
## ASV9078     -9.990089e-05 -1.056076e-04 -1.116606e-04 -1.180815e-04
## ASV0027     -5.414058e-04 -5.669870e-04 -5.937615e-04 -6.217831e-04
## ASV0546     -2.317849e-04 -2.418201e-04 -2.522472e-04 -2.630781e-04
## ASV1136      5.987141e-04  6.260076e-04  6.544957e-04  6.842270e-04
## ASV3081      2.833263e-04  2.963436e-04  3.099427e-04  3.241487e-04
## ASV0531      1.285861e-04  1.348842e-04  1.414939e-04  1.484307e-04
## ASV2525      1.646638e-04  1.719825e-04  1.796058e-04  1.875448e-04
## ASV1083     -5.774999e-05 -5.976217e-05 -6.181067e-05 -6.389299e-05
## ASV0424      1.032529e-04  1.079090e-04  1.127635e-04  1.178242e-04
## ASV0644      1.968954e-05  2.143508e-05  2.332744e-05  2.537793e-05
## ASV6007     -2.339222e-05 -2.546744e-05 -2.771741e-05 -3.015565e-05
## ASV0564      1.495609e-04  1.570215e-04  1.648619e-04  1.731013e-04
## ASV1938      1.544050e-04  1.607407e-04  1.672940e-04  1.740690e-04
## ASV6516     -3.653578e-04 -3.820948e-04 -3.995698e-04 -4.178131e-04
## ASV0503     -4.235146e-04 -4.418187e-04 -4.608327e-04 -4.805774e-04
## ASV6913     -4.311471e-04 -4.503222e-04 -4.703002e-04 -4.911113e-04
## ASV0164     -3.363332e-04 -3.522650e-04 -3.689467e-04 -3.864130e-04
## ASV1576      4.049624e-04  4.234874e-04  4.428318e-04  4.630296e-04
## ASV1725      2.026059e-04  2.127784e-04  2.234722e-04  2.347137e-04
## ASV4501      1.676437e-04  1.744852e-04  1.815560e-04  1.888595e-04
## ASV10678    -3.586624e-04 -3.750321e-04 -3.921177e-04 -4.099480e-04
## ASV0944      2.948997e-04  3.089084e-04  3.235795e-04  3.389439e-04
## ASV2292      4.599307e-04  4.806372e-04  5.022239e-04  5.247237e-04
## ASV1090      3.006457e-04  3.144315e-04  3.288277e-04  3.438598e-04
## ASV9117     -1.411003e-04 -1.466839e-04 -1.524424e-04 -1.583778e-04
## ASV0285     -1.859925e-04 -1.956360e-04 -2.058008e-04 -2.165158e-04
## ASV0463     -2.904188e-04 -3.030670e-04 -3.162144e-04 -3.298761e-04
## ASV3199      2.508726e-04  2.616263e-04  2.727912e-04  2.843790e-04
## ASV0150     -1.055507e-04 -1.108771e-04 -1.164796e-04 -1.223727e-04
## ASV6583     -1.430544e-04 -1.488508e-04 -1.548437e-04 -1.610370e-04
## ASV0392      2.380869e-04  2.489687e-04  2.603275e-04  2.721826e-04
## ASV14007    -2.890353e-04 -3.019642e-04 -3.154340e-04 -3.294639e-04
## ASV0177     -1.583642e-04 -1.650969e-04 -1.720798e-04 -1.793190e-04
## ASV6448     -1.299608e-04 -1.370511e-04 -1.445492e-04 -1.524790e-04
## ASV5399     -5.470566e-05 -5.821939e-05 -6.197172e-05 -6.597879e-05
## ASV0277     -6.011540e-05 -6.294522e-05 -6.590536e-05 -6.900144e-05
## ASV2599      1.062272e-04  1.103172e-04  1.145243e-04  1.188486e-04
## ASV13465    -8.358079e-05 -8.654853e-05 -8.957696e-05 -9.266336e-05
## ASV2412      1.512310e-04  1.582457e-04  1.655778e-04  1.732410e-04
## ASV0423      2.970356e-04  3.114339e-04  3.265386e-04  3.423848e-04
## ASV5187      1.778481e-04  1.849586e-04  1.922994e-04  1.998739e-04
## ASV0701     -7.076270e-04 -7.407619e-04 -7.754212e-04 -8.116723e-04
## ASV4248      1.744069e-04  1.832517e-04  1.925576e-04  2.023488e-04
## ASV0519      2.963442e-04  3.105358e-04  3.254048e-04  3.409830e-04
## ASV0764      5.054573e-05  5.328338e-05  5.617856e-05  5.924077e-05
## ASV5385     -3.686638e-04 -3.859005e-04 -4.039296e-04 -4.227863e-04
## ASV3021     -2.093600e-04 -2.180892e-04 -2.271343e-04 -2.365029e-04
## ASV4119     -1.143240e-04 -1.188659e-04 -1.235521e-04 -1.283847e-04
## ASV2534      5.568049e-05  5.795687e-05  6.031214e-05  6.274803e-05
## ASV1061      2.821049e-04  2.962673e-04  3.111649e-04  3.268372e-04
## ASV0670      3.940373e-04  4.125083e-04  4.318321e-04  4.520469e-04
## ASV1384      1.719236e-04  1.805791e-04  1.896799e-04  1.992491e-04
## ASV1981      3.686890e-04  3.862034e-04  4.045435e-04  4.237475e-04
## ASV9632     -1.116960e-04 -1.156077e-04 -1.195942e-04 -1.236514e-04
## ASV4564      9.069674e-05  9.503853e-05  9.958763e-05  1.043537e-04
## ASV5289     -8.492381e-05 -8.902106e-05 -9.331896e-05 -9.782766e-05
## ASV0516      7.443231e-04  7.789492e-04  8.151452e-04  8.529782e-04
## ASV1463     -2.686930e-04 -2.807751e-04 -2.933684e-04 -3.064920e-04
## ASV0969      1.244420e-04  1.299151e-04  1.356080e-04  1.415276e-04
## ASV1113     -3.462474e-04 -3.623207e-04 -3.791209e-04 -3.966791e-04
## ASV1234     -1.757422e-05 -1.939978e-05 -2.140073e-05 -2.359294e-05
## ASV3814      4.315147e-05  4.385341e-05  4.448258e-05  4.502834e-05
## ASV1000      3.538454e-04  3.698633e-04  3.865682e-04  4.039862e-04
## ASV0079     -3.092876e-05 -3.281468e-05 -3.482588e-05 -3.697115e-05
## ASV0145      1.164648e-04  1.212897e-04  1.262856e-04  1.314562e-04
## ASV0457     -4.483720e-04 -4.686205e-04 -4.897333e-04 -5.117432e-04
## ASV1485      1.457680e-04  1.527639e-04  1.600980e-04  1.677865e-04
## ASV0535     -9.284510e-05 -9.673138e-05 -1.007591e-04 -1.049317e-04
## ASV0259     -2.944806e-04 -3.080670e-04 -3.222583e-04 -3.370794e-04
## ASV0570      2.162909e-05  2.307210e-05  2.461860e-05  2.627618e-05
## ASV0906      3.775234e-04  3.945510e-04  4.123047e-04  4.308120e-04
## ASV1748     -2.261585e-04 -2.375588e-04 -2.495497e-04 -2.621621e-04
## ASV5520     -1.345748e-04 -1.417947e-04 -1.494209e-04 -1.574768e-04
## ASV2288     -4.457836e-04 -4.660581e-04 -4.872118e-04 -5.092789e-04
## ASV1887     -8.774076e-05 -9.270921e-05 -9.797098e-05 -1.035431e-04
## ASV0374     -1.352582e-04 -1.410388e-04 -1.470378e-04 -1.532609e-04
## ASV0823      4.239416e-04  4.427365e-04  4.623079e-04  4.826834e-04
## ASV0717      2.138242e-04  2.237750e-04  2.341773e-04  2.450505e-04
## ASV0431      1.519536e-04  1.588822e-04  1.661135e-04  1.736597e-04
## ASV1030      6.256715e-04  6.555888e-04  6.869348e-04  7.197769e-04
## ASV1082     -9.180238e-05 -9.609804e-05 -1.005903e-04 -1.052877e-04
## ASV2684      6.138193e-05  6.501420e-05  6.887176e-05  7.296839e-05
## ASV0051      5.475409e-04  5.730567e-04  5.997372e-04  6.276337e-04
## ASV0513      2.679084e-05  2.832068e-05  2.994626e-05  3.167412e-05
## ASV0581      7.060344e-04  7.390858e-04  7.736566e-04  8.098140e-04
## ASV7282      1.214723e-04  1.277006e-04  1.342627e-04  1.411774e-04
## ASV3009     -3.861178e-04 -4.040600e-04 -4.228149e-04 -4.424172e-04
## ASV2106     -1.934965e-04 -2.018723e-04 -2.105794e-04 -2.196288e-04
## ASV1012      1.253410e-04  1.316180e-04  1.382150e-04  1.451479e-04
## ASV0921     -7.811971e-06 -7.990705e-06 -8.159679e-06 -8.316727e-06
## ASV0010     -5.501519e-04 -5.761577e-04 -6.033782e-04 -6.318683e-04
## ASV1178      1.377876e-05  1.472286e-05  1.573429e-05  1.681774e-05
## ASV2848     -2.918116e-04 -3.048379e-04 -3.184140e-04 -3.325609e-04
## ASV0586      8.002105e-04  8.377628e-04  8.770503e-04  9.181507e-04
## ASV4225      4.366929e-05  4.696226e-05  5.050567e-05  5.431754e-05
## ASV2156     -3.346950e-04 -3.504092e-04 -3.668503e-04 -3.840506e-04
## ASV9778     -2.099561e-04 -2.195816e-04 -2.296322e-04 -2.401253e-04
## ASV0493     -4.591725e-04 -4.797998e-04 -5.013010e-04 -5.237087e-04
## ASV3770      7.407555e-05  7.671934e-05  7.941961e-05  8.217430e-05
## ASV0470      5.644904e-04  5.905987e-04  6.178799e-04  6.463837e-04
## ASV0262     -2.400574e-04 -2.521863e-04 -2.649463e-04 -2.783709e-04
## ASV0998      3.474682e-04  3.637753e-04  3.808366e-04  3.986861e-04
## ASV7708     -9.080246e-05 -9.467921e-05 -9.870063e-05 -1.028702e-04
## ASV0453     -9.892913e-06 -1.023664e-05 -1.058934e-05 -1.095132e-05
## ASV0044      7.080648e-04  7.407820e-04  7.749653e-04  8.106764e-04
## ASV5490      1.119202e-04  1.168943e-04  1.220721e-04  1.274606e-04
## ASV2638      3.734035e-05  3.954908e-05  4.189597e-05  4.438968e-05
## ASV0829     -6.106804e-05 -6.334606e-05 -6.568238e-05 -6.807631e-05
## ASV0601      1.298289e-04  1.360982e-04  1.426732e-04  1.495690e-04
## ASV0234      3.132358e-04  3.278492e-04  3.431307e-04  3.591095e-04
## ASV0133      4.058768e-04  4.246676e-04  4.443031e-04  4.648191e-04
## ASV0323      4.326104e-04  4.531732e-04  4.747115e-04  4.972715e-04
## ASV0854     -3.473234e-05 -3.619704e-05 -3.771477e-05 -3.928665e-05
## ASV0110      5.437838e-04  5.691965e-04  5.957743e-04  6.235686e-04
## ASV0816      2.958301e-05  3.086860e-05  3.220496e-05  3.359369e-05
## ASV1031     -8.130895e-05 -8.468543e-05 -8.818236e-05 -9.180256e-05
## ASV0144     -2.244210e-04 -2.347878e-04 -2.456198e-04 -2.569369e-04
## ASV0020     -1.007949e-04 -1.060509e-04 -1.115999e-04 -1.174596e-04
## ASV0962     -1.829119e-04 -1.913510e-04 -2.001658e-04 -2.093720e-04
## ASV0794      3.633420e-04  3.810782e-04  3.996894e-04  4.192190e-04
## ASV7117     -1.806688e-04 -1.888398e-04 -1.973616e-04 -2.062478e-04
## ASV1008     -1.335665e-04 -1.400652e-04 -1.468846e-04 -1.540409e-04
## ASV0096      5.851473e-04  6.124820e-04  6.410688e-04  6.709627e-04
## ASV0128     -3.530669e-04 -3.702065e-04 -3.881917e-04 -4.070651e-04
## ASV5232      2.751620e-04  2.885056e-04  3.025012e-04  3.171807e-04
## ASV0031      2.025307e-05  2.102621e-05  2.181964e-05  2.263303e-05
## ASV1744     -3.582395e-05 -3.739883e-05 -3.904221e-05 -4.075746e-05
## ASV0289      3.270492e-04  3.422984e-04  3.582461e-04  3.749235e-04
## ASV7413     -7.975924e-05 -8.451789e-05 -8.958009e-05 -9.496569e-05
## ASV0822     -3.935355e-04 -4.111106e-04 -4.294181e-04 -4.484839e-04
## ASV8111     -3.449749e-04 -3.603435e-04 -3.763575e-04 -3.930414e-04
## ASV0687      2.510946e-04  2.632692e-04  2.760374e-04  2.894280e-04
## ASV0112      8.912625e-05  9.289725e-05  9.680580e-05  1.008549e-04
## ASV0987      2.023092e-04  2.121619e-04  2.225034e-04  2.333588e-04
## ASV5332     -9.965027e-05 -1.033844e-04 -1.072204e-04 -1.111584e-04
## ASV1129     -2.579359e-04 -2.699586e-04 -2.825322e-04 -2.956810e-04
## ASV1274     -8.362948e-05 -8.748836e-05 -9.151979e-05 -9.573100e-05
## ASV0119      4.767872e-04  4.990326e-04  5.222946e-04  5.466177e-04
## ASV0890      1.183459e-04  1.239222e-04  1.297569e-04  1.358612e-04
## ASV0848      6.932925e-04  7.257861e-04  7.597771e-04  7.953323e-04
## ASV5944     -3.752588e-04 -3.925061e-04 -4.105188e-04 -4.293284e-04
## ASV19741    -3.574239e-04 -3.738073e-04 -3.909140e-04 -4.087737e-04
## ASV0504     -4.105364e-04 -4.289398e-04 -4.481192e-04 -4.681032e-04
## ASV2146     -2.630265e-04 -2.746451e-04 -2.867447e-04 -2.993430e-04
## ASV0089     -2.205914e-04 -2.309452e-04 -2.417769e-04 -2.531077e-04
## ASV2301     -2.408214e-04 -2.522074e-04 -2.641272e-04 -2.766053e-04
## ASV2982      9.279032e-05  9.827835e-05  1.041096e-04  1.103055e-04
## ASV0891     -3.010719e-04 -3.149410e-04 -3.294275e-04 -3.445567e-04
## ASV0093      4.918156e-04  5.146084e-04  5.384297e-04  5.633234e-04
## ASV0042      2.383492e-04  2.494024e-04  2.609548e-04  2.730277e-04
## ASV0980      3.253909e-04  3.400863e-04  3.554081e-04  3.713798e-04
## ASV0069     -7.937684e-05 -8.320391e-05 -8.721654e-05 -9.142370e-05
## ASV1364     -5.378255e-05 -5.610992e-05 -5.852690e-05 -6.103592e-05
## ASV0524     -9.416295e-05 -9.877928e-05 -1.036270e-04 -1.087181e-04
## ASV0435      6.550907e-04  6.858835e-04  7.181044e-04  7.518176e-04
## ASV0517     -2.683158e-04 -2.809455e-04 -2.941627e-04 -3.079941e-04
## ASV3167     -1.186396e-04 -1.245324e-04 -1.307247e-04 -1.372319e-04
## ASV4280     -3.954262e-05 -4.121740e-05 -4.295460e-05 -4.475591e-05
## ASV1158      1.643348e-04  1.726122e-04  1.813129e-04  1.904579e-04
## ASV2214      1.177299e-04  1.229818e-04  1.284566e-04  1.341633e-04
## ASV0544     -1.504618e-04 -1.577246e-04 -1.653412e-04 -1.733290e-04
## ASV5326     -2.706403e-05 -2.830447e-05 -2.960048e-05 -3.095456e-05
## ASV3765     -3.898780e-04 -4.080011e-04 -4.269452e-04 -4.467456e-04
## ASV4646     -1.109085e-05 -1.229619e-05 -1.361226e-05 -1.504796e-05
## ASV0090      4.029287e-05  4.194356e-05  4.364844e-05  4.540797e-05
## ASV3680      3.556121e-04  3.711977e-04  3.874067e-04  4.042587e-04
## ASV0111      6.136390e-05  6.401493e-05  6.676753e-05  6.962436e-05
## ASV0768      2.269580e-04  2.377978e-04  2.491566e-04  2.610595e-04
## ASV4862     -1.080969e-05 -1.110370e-05 -1.139118e-05 -1.166995e-05
## ASV1742     -2.896621e-04 -3.023558e-04 -3.155623e-04 -3.292990e-04
## ASV3701     -3.980928e-05 -4.122365e-05 -4.266741e-05 -4.413936e-05
## ASV2386     -1.789760e-04 -1.872806e-04 -1.959598e-04 -2.050294e-04
## ASV0375     -4.142275e-04 -4.328884e-04 -4.523473e-04 -4.726349e-04
## ASV2796      1.057921e-04  1.103018e-04  1.149840e-04  1.198440e-04
## ASV1369      2.845412e-04  2.973430e-04  3.106945e-04  3.246176e-04
## ASV10272    -2.598544e-04 -2.717510e-04 -2.841700e-04 -2.971321e-04
## ASV10354    -2.598289e-04 -2.717232e-04 -2.841395e-04 -2.970988e-04
## ASV1067     -1.965638e-05 -2.054490e-05 -2.147120e-05 -2.243664e-05
## ASV1900      5.450755e-04  5.706748e-04  5.974593e-04  6.254821e-04
## ASV4079     -9.347527e-05 -9.798055e-05 -1.027038e-04 -1.076556e-04
## ASV4149      3.640815e-04  3.801607e-04  3.968932e-04  4.143006e-04
## ASV5140     -2.598036e-04 -2.716955e-04 -2.841092e-04 -2.970656e-04
## ASV10782    -9.342328e-06 -9.472156e-06 -9.579208e-06 -9.659824e-06
## ASV4273     -5.938019e-05 -6.187653e-05 -6.446131e-05 -6.713604e-05
## ASV8121      2.499075e-04  2.615894e-04  2.738080e-04  2.865873e-04
## ASV8438     -2.597814e-04 -2.716713e-04 -2.840829e-04 -2.970370e-04
## ASV9390     -2.597559e-04 -2.716434e-04 -2.840524e-04 -2.970036e-04
## ASV1340      3.610646e-04  3.781298e-04  3.959944e-04  4.146949e-04
## ASV2650     -3.857179e-04 -4.031518e-04 -4.213307e-04 -4.402827e-04
## ASV4674      1.971479e-04  2.062871e-04  2.158379e-04  2.258178e-04
## ASV10492    -1.406231e-05 -1.464483e-05 -1.524762e-05 -1.587107e-05
## ASV11430    -2.597185e-04 -2.716025e-04 -2.840078e-04 -2.969550e-04
## ASV12135    -2.596930e-04 -2.715747e-04 -2.839773e-04 -2.969217e-04
## ASV14970    -2.596675e-04 -2.715468e-04 -2.839468e-04 -2.968884e-04
## ASV1954      2.973455e-04  3.112113e-04  3.257091e-04  3.408661e-04
## ASV2613      4.631572e-04  4.845658e-04  5.069339e-04  5.303018e-04
## ASV2757      1.829560e-04  1.910650e-04  1.995063e-04  2.082914e-04
## ASV2909     -2.750179e-04 -2.880437e-04 -3.016829e-04 -3.159641e-04
## ASV2954     -5.350661e-05 -5.587084e-05 -5.833078e-05 -6.088949e-05
## ASV2969      2.576402e-04  2.699644e-04  2.828797e-04  2.964144e-04
## ASV3410      5.342342e-05  5.611081e-05  5.893901e-05  6.191579e-05
## ASV3575      1.347164e-04  1.409425e-04  1.474485e-04  1.542462e-04
## ASV4275      2.966205e-04  3.099383e-04  3.238170e-04  3.382771e-04
## ASV4652      5.110362e-05  5.371653e-05  5.646957e-05  5.937068e-05
## ASV4761      2.964075e-04  3.097344e-04  3.236232e-04  3.380943e-04
## ASV6003      2.277058e-04  2.387205e-04  2.502749e-04  2.623960e-04
## ASV6110     -2.597223e-04 -2.716069e-04 -2.840127e-04 -2.969605e-04
## ASV7427      1.681736e-04  1.759068e-04  1.839828e-04  1.924155e-04
## ASV8092     -2.597058e-04 -2.715888e-04 -2.839929e-04 -2.969389e-04
## ASV8169     -2.596803e-04 -2.715610e-04 -2.839625e-04 -2.969056e-04
## ASV9693      1.134463e-04  1.187435e-04  1.242826e-04  1.300744e-04
## ASV10913     1.238769e-04  1.298141e-04  1.360370e-04  1.425593e-04
## ASV1979     -4.143180e-05 -4.322271e-05 -4.508296e-05 -4.701456e-05
## ASV3772      3.209466e-04  3.355510e-04  3.507896e-04  3.666875e-04
## ASV0113      6.423054e-05  6.712050e-05  7.013335e-05  7.327376e-05
## ASV1800     -2.550197e-05 -2.664630e-05 -2.783613e-05 -2.907251e-05
## ASV2335     -3.386744e-04 -3.538527e-04 -3.696760e-04 -3.861692e-04
## ASV0692      1.104128e-04  1.155858e-04  1.209965e-04  1.266550e-04
## ASV1120      1.428596e-04  1.495630e-04  1.565763e-04  1.639137e-04
## ASV1434     -7.549769e-04 -7.902735e-04 -8.271901e-04 -8.657981e-04
## ASV0076     -8.345947e-05 -8.746712e-05 -9.166764e-05 -9.607028e-05
## ASV0361      5.647613e-04  5.912206e-04  6.188992e-04  6.478514e-04
## ASV2231     -1.886957e-04 -1.981158e-04 -2.080226e-04 -2.184423e-04
## ASV2018     -8.129183e-06 -8.547648e-06 -8.989395e-06 -9.455899e-06
## ASV1529      4.727456e-04  4.952297e-04  5.187810e-04  5.434500e-04
## ASV0841     -2.302636e-05 -2.390519e-05 -2.480627e-05 -2.572896e-05
## ASV2556     -2.827171e-04 -2.956953e-04 -3.092468e-04 -3.233949e-04
## ASV2777      3.553913e-04  3.710081e-04  3.872520e-04  4.041428e-04
## ASV0355      2.908014e-04  3.043892e-04  3.186002e-04  3.334622e-04
## ASV5169     -4.054717e-04 -4.243104e-04 -4.440013e-04 -4.645810e-04
## ASV3091      1.953759e-04  2.047134e-04  2.144983e-04  2.247522e-04
## ASV2435      2.874097e-04  3.007271e-04  3.146441e-04  3.291861e-04
## ASV6822     -1.816202e-04 -1.898547e-04 -1.984430e-04 -2.073986e-04
## ASV12605    -4.411661e-04 -4.616352e-04 -4.830287e-04 -5.053862e-04
## ASV0286     -2.917007e-04 -3.051192e-04 -3.191377e-04 -3.337820e-04
## ASV0074     -1.258994e-05 -1.356067e-05 -1.460941e-05 -1.574240e-05
## ASV2485     -2.222127e-05 -2.349821e-05 -2.485890e-05 -2.630971e-05
## ASV1233     -5.610508e-04 -5.872484e-04 -6.146470e-04 -6.433000e-04
## ASV0356     -2.660513e-04 -2.781205e-04 -2.907132e-04 -3.038501e-04
## ASV2918     -3.394453e-04 -3.550227e-04 -3.712891e-04 -3.882728e-04
## ASV1427      9.364956e-07  8.796643e-07  8.105913e-07  7.278127e-07
## ASV1409      3.261081e-04  3.416104e-04  3.578478e-04  3.748549e-04
## ASV0770      1.057506e-04  1.104128e-04  1.152628e-04  1.203064e-04
## ASV1403     -3.938671e-04 -4.120624e-04 -4.310726e-04 -4.509316e-04
## ASV0314     -2.136112e-04 -2.235467e-04 -2.339322e-04 -2.447868e-04
## ASV0187      4.019973e-06  3.858384e-06  3.659920e-06  3.420646e-06
## ASV0313     -2.903695e-04 -3.037365e-04 -3.176975e-04 -3.322772e-04
## ASV1087      4.967401e-04  5.198950e-04  5.441061e-04  5.694197e-04
## ASV1970      2.921398e-05  3.054264e-05  3.192952e-05  3.337704e-05
## ASV0754      4.005293e-04  4.192343e-04  4.387957e-04  4.592514e-04
## ASV3775     -2.735365e-04 -2.864981e-04 -3.000704e-04 -3.142816e-04
## ASV0132      1.156015e-04  1.209578e-04  1.265553e-04  1.324044e-04
## ASV2329     -7.739833e-05 -8.160531e-05 -8.605210e-05 -9.075257e-05
## ASV0561      3.473998e-04  3.633976e-04  3.801066e-04  3.975561e-04
## ASV0130     -4.226627e-04 -4.425101e-04 -4.632748e-04 -4.849979e-04
## ASV0226      4.763617e-04  4.985287e-04  5.217027e-04  5.459272e-04
## ASV12648    -3.333165e-04 -3.484280e-04 -3.641969e-04 -3.806501e-04
## ASV0204      4.749312e-04  4.970268e-04  5.201258e-04  5.442714e-04
## ASV0767      8.442933e-05  8.811140e-05  9.193776e-05  9.591251e-05
## ASV0335     -2.591304e-04 -2.712336e-04 -2.838901e-04 -2.971240e-04
## ASV5901     -7.772217e-05 -8.103802e-05 -8.448110e-05 -8.805533e-05
## ASV0596     -1.043226e-04 -1.088850e-04 -1.136279e-04 -1.185567e-04
## ASV9271      1.016046e-04  1.070935e-04  1.128951e-04  1.190281e-04
## ASV0904      4.218421e-04  4.417787e-04  4.626497e-04  4.844983e-04
## ASV15270    -1.170264e-04 -1.231475e-04 -1.296000e-04 -1.364018e-04
## ASV0990     -1.182068e-04 -1.238103e-04 -1.296780e-04 -1.358222e-04
## ASV0155     -2.543041e-04 -2.661465e-04 -2.785281e-04 -2.914726e-04
## ASV0086     -3.654581e-06 -3.835957e-06 -4.026540e-06 -4.226806e-06
## ASV2581     -2.088700e-05 -2.179125e-05 -2.272920e-05 -2.370145e-05
## ASV1579     -2.953858e-04 -3.094831e-04 -3.242525e-04 -3.397260e-04
## ASV7730     -1.263670e-05 -1.372874e-05 -1.490859e-05 -1.618242e-05
## ASV0897      1.245283e-04  1.305055e-04  1.367710e-04  1.433388e-04
## ASV1975      5.750972e-04  6.019074e-04  6.299435e-04  6.592599e-04
##                                                                    
## (Intercept)  1.964718e-06  2.007278e-06  2.018617e-06  1.989169e-06
## ASV1236      3.144430e-04  3.284526e-04  3.430418e-04  3.582307e-04
## ASV0421     -5.635865e-04 -5.890419e-04 -6.155838e-04 -6.432528e-04
## ASV0691     -4.810032e-04 -5.018369e-04 -5.234800e-04 -5.459560e-04
## ASV0899      6.402212e-07  1.305556e-06  2.055053e-06  2.896586e-06
## ASV1004      6.367831e-04  6.653734e-04  6.951667e-04  7.262063e-04
## ASV1041     -4.338409e-04 -4.534689e-04 -4.739358e-04 -4.952728e-04
## ASV1058      5.931334e-04  6.198381e-04  6.476749e-04  6.766855e-04
## ASV12542     1.816636e-04  1.896197e-04  1.978937e-04  2.064954e-04
## ASV1294      6.919034e-04  7.233597e-04  7.561766e-04  7.904066e-04
## ASV13113     2.523058e-04  2.643643e-04  2.770013e-04  2.902448e-04
## ASV1318      6.021811e-04  6.293509e-04  6.576764e-04  6.872006e-04
## ASV2269     -1.801714e-04 -1.883429e-04 -1.968645e-04 -2.057492e-04
## ASV2542      3.906657e-04  4.090005e-04  4.281823e-04  4.482491e-04
## ASV2660     -3.468862e-04 -3.623796e-04 -3.785171e-04 -3.953210e-04
## ASV2737     -2.006956e-05 -2.120178e-05 -2.240116e-05 -2.367173e-05
## ASV2840      4.607659e-04  4.812229e-04  5.025195e-04  5.246839e-04
## ASV3053      2.448424e-05  2.551249e-05  2.657891e-05  2.768457e-05
## ASV3077      1.435756e-04  1.499907e-04  1.566744e-04  1.636362e-04
## ASV3134      5.062855e-04  5.302995e-04  5.554484e-04  5.817855e-04
## ASV3140      2.222044e-04  2.326350e-04  2.435451e-04  2.549559e-04
## ASV3579      8.998681e-05  9.452646e-05  9.930572e-05  1.043380e-04
## ASV6119     -1.801302e-04 -1.882979e-04 -1.968154e-04 -2.056957e-04
## ASV7557     -1.801091e-04 -1.882748e-04 -1.967902e-04 -2.056681e-04
## ASV8422      9.608799e-05  1.001615e-04  1.043868e-04  1.087677e-04
## ASV1086     -4.952122e-05 -5.167616e-05 -5.391688e-05 -5.624619e-05
## ASV1310      3.402975e-04  3.556961e-04  3.717537e-04  3.884950e-04
## ASV15750    -8.512944e-05 -8.892640e-05 -9.287901e-05 -9.699226e-05
## ASV16905    -1.801002e-04 -1.882651e-04 -1.967795e-04 -2.056564e-04
## ASV2033      3.384559e-04  3.542912e-04  3.708540e-04  3.881762e-04
## ASV2089      1.235482e-04  1.291750e-04  1.350445e-04  1.411658e-04
## ASV2127      4.883863e-04  5.103517e-04  5.332462e-04  5.571039e-04
## ASV2725      5.514646e-04  5.758989e-04  6.013329e-04  6.278003e-04
## ASV2804     -1.800946e-04 -1.882591e-04 -1.967729e-04 -2.056493e-04
## ASV3075      3.507823e-04  3.666771e-04  3.832573e-04  4.005497e-04
## ASV3327      3.322040e-04  3.477567e-04  3.640260e-04  3.810439e-04
## ASV3342      3.613632e-04  3.781017e-04  3.955924e-04  4.138668e-04
## ASV3532     -3.272106e-04 -3.424032e-04 -3.582820e-04 -3.748762e-04
## ASV3600      4.111458e-04  4.300329e-04  4.497571e-04  4.703528e-04
## ASV4013      3.451064e-04  3.607265e-04  3.770166e-04  3.940019e-04
## ASV4136      3.402468e-04  3.553766e-04  3.711303e-04  3.875293e-04
## ASV4195      1.800642e-04  1.882259e-04  1.967367e-04  2.056097e-04
## ASV4407     -1.800431e-04 -1.882028e-04 -1.967115e-04 -2.055822e-04
## ASV4717      6.469083e-06  6.475605e-06  6.458492e-06  6.414962e-06
## ASV6794      1.796414e-04  1.873108e-04  1.952697e-04  2.035257e-04
## ASV8324     -1.800358e-04 -1.881947e-04 -1.967025e-04 -2.055722e-04
## ASV8981     -4.818255e-05 -5.017284e-05 -5.222904e-05 -5.435168e-05
## ASV9859      1.408738e-04  1.478215e-04  1.551225e-04  1.627958e-04
## ASV0936     -2.827098e-04 -2.955841e-04 -3.090187e-04 -3.230357e-04
## ASV12683    -2.986315e-05 -3.135408e-05 -3.291997e-05 -3.456447e-05
## ASV1293      4.136998e-04  4.322205e-04  4.515157e-04  4.716128e-04
## ASV13055    -4.359032e-05 -4.547530e-05 -4.743101e-05 -4.945896e-05
## ASV17063    -1.800004e-04 -1.881562e-04 -1.966607e-04 -2.055268e-04
## ASV2228      1.799793e-04  1.881331e-04  1.966355e-04  2.054992e-04
## ASV2769     -3.384830e-05 -3.523416e-05 -3.666483e-05 -3.814057e-05
## ASV2803      8.199364e-05  8.541829e-05  8.896558e-05  9.263822e-05
## ASV2896      2.257052e-04  2.361020e-04  2.469644e-04  2.583124e-04
## ASV3062      6.995508e-05  7.346973e-05  7.716858e-05  8.106186e-05
## ASV3107      2.733718e-04  2.860247e-04  2.992472e-04  3.130637e-04
## ASV3265      5.390756e-04  5.632459e-04  5.884311e-04  6.146676e-04
## ASV3666     -1.230810e-05 -1.289738e-05 -1.351399e-05 -1.415907e-05
## ASV4497      1.282195e-04  1.340144e-04  1.400582e-04  1.463606e-04
## ASV6914     -6.409496e-05 -6.711003e-05 -7.026354e-05 -7.356142e-05
## ASV0576     -6.296684e-04 -6.572143e-04 -6.858563e-04 -7.156283e-04
## ASV0673      1.714352e-04  1.798098e-04  1.885987e-04  1.978223e-04
## ASV0772      1.919657e-04  2.006631e-04  2.097360e-04  2.191992e-04
## ASV0862     -1.550619e-04 -1.618273e-04 -1.688599e-04 -1.761677e-04
## ASV0898      1.618166e-04  1.695877e-04  1.777326e-04  1.862690e-04
## ASV0910      3.492148e-04  3.657773e-04  3.831207e-04  4.012813e-04
## ASV0964     -2.312108e-04 -2.415379e-04 -2.522955e-04 -2.634989e-04
## ASV10059     1.648122e-04  1.727535e-04  1.810823e-04  1.898181e-04
## ASV10263    -1.800928e-04 -1.882573e-04 -1.967712e-04 -2.056476e-04
## ASV1088      1.848982e-04  1.936754e-04  2.028695e-04  2.125004e-04
## ASV1101      3.121846e-04  3.264283e-04  3.412916e-04  3.567985e-04
## ASV1183      2.012598e-04  2.105892e-04  2.203376e-04  2.305225e-04
## ASV11956     7.341594e-05  7.637169e-05  7.942287e-05  8.257052e-05
## ASV12774    -2.843701e-05 -2.986860e-05 -3.137370e-05 -3.295607e-05
## ASV1321      8.164257e-05  8.583328e-05  9.025007e-05  9.490583e-05
## ASV13793    -1.800674e-04 -1.882294e-04 -1.967407e-04 -2.056142e-04
## ASV14482    -1.848802e-05 -1.951219e-05 -2.059540e-05 -2.174103e-05
## ASV15483     1.269760e-04  1.328876e-04  1.390696e-04  1.455341e-04
## ASV2062      7.939321e-04  8.301887e-04  8.680293e-04  9.075166e-04
## ASV2132      3.640376e-04  3.810463e-04  3.988355e-04  4.174396e-04
## ASV2413      5.101753e-04  5.330945e-04  5.569821e-04  5.818738e-04
## ASV2490      3.321565e-04  3.467401e-04  3.619077e-04  3.776777e-04
## ASV2594      1.842649e-04  1.926527e-04  2.014078e-04  2.105456e-04
## ASV2822     -1.801018e-04 -1.882671e-04 -1.967820e-04 -2.056594e-04
## ASV2863      3.111841e-04  3.250691e-04  3.395307e-04  3.545887e-04
## ASV2910      4.050178e-04  4.230385e-04  4.418042e-04  4.613408e-04
## ASV2980      1.482263e-04  1.548932e-04  1.618401e-04  1.690769e-04
## ASV3307      1.800665e-04  1.882285e-04  1.967398e-04  2.056134e-04
## ASV3474      2.837127e-04  2.971621e-04  3.112458e-04  3.259932e-04
## ASV3502      5.871584e-04  6.140723e-04  6.421723e-04  6.715064e-04
## ASV4236      2.964292e-04  3.096550e-04  3.234305e-04  3.377750e-04
## ASV4842     -9.982614e-05 -1.044571e-04 -1.092948e-04 -1.143475e-04
## ASV4894     -1.800907e-04 -1.882550e-04 -1.967689e-04 -2.056452e-04
## ASV5290      2.201502e-04  2.301888e-04  2.406658e-04  2.515987e-04
## ASV5501      4.123191e-05  4.310627e-05  4.506340e-05  4.710683e-05
## ASV5795      1.488711e-04  1.558046e-04  1.630547e-04  1.706351e-04
## ASV5987     -1.800988e-04 -1.882639e-04 -1.967787e-04 -2.056560e-04
## ASV6267     -1.800777e-04 -1.882408e-04 -1.967534e-04 -2.056284e-04
## ASV6862      3.412909e-04  3.561857e-04  3.716705e-04  3.877633e-04
## ASV7145      5.997456e-05  6.241895e-05  6.494585e-05  6.755666e-05
## ASV7673     -1.800710e-04 -1.882335e-04 -1.967453e-04 -2.056195e-04
## ASV7789      6.664126e-05  7.004881e-05  7.364041e-05  7.742675e-05
## ASV7809     -2.257792e-05 -2.344174e-05 -2.432649e-05 -2.523132e-05
## ASV8002     -1.800553e-04 -1.882164e-04 -1.967268e-04 -2.055994e-04
## ASV8205      1.024063e-04  1.070090e-04  1.118084e-04  1.168121e-04
## ASV9155     -1.355005e-04 -1.416108e-04 -1.479791e-04 -1.546147e-04
## ASV9221     -2.304875e-05 -2.401676e-05 -2.501825e-05 -2.605367e-05
## ASV9311     -1.800260e-04 -1.881844e-04 -1.966919e-04 -2.055613e-04
## ASV9557     -1.800049e-04 -1.881614e-04 -1.966667e-04 -2.055338e-04
## ASV9936     -1.799838e-04 -1.881383e-04 -1.966415e-04 -2.055063e-04
## ASV1445      4.166919e-04  4.360295e-04  4.562417e-04  4.773657e-04
## ASV4232      3.515829e-04  3.680891e-04  3.853613e-04  4.034343e-04
## ASV6479      1.919496e-06  2.515580e-06  3.186272e-06  3.939166e-06
## ASV0142     -9.019050e-04 -9.420152e-04 -9.837810e-04 -1.027260e-03
## ASV0378     -2.980769e-04 -3.112869e-04 -3.250362e-04 -3.393425e-04
## ASV1122      5.502518e-04  5.757827e-04  6.024669e-04  6.303537e-04
## ASV0123     -8.834244e-04 -9.226844e-04 -9.635623e-04 -1.006114e-03
## ASV2064      8.719678e-05  9.077637e-05  9.448080e-05  9.831280e-05
## ASV4459     -1.000181e-04 -1.045763e-04 -1.093313e-04 -1.142907e-04
## ASV0448      1.606657e-04  1.686777e-04  1.771011e-04  1.859576e-04
## ASV0397      4.124647e-04  4.315298e-04  4.514485e-04  4.722566e-04
## ASV0485      5.721197e-04  5.981035e-04  6.252106e-04  6.534848e-04
## ASV1566      4.809115e-04  5.030136e-04  5.260941e-04  5.501931e-04
## ASV1365      3.097805e-04  3.239709e-04  3.387863e-04  3.542518e-04
## ASV1065      6.397259e-04  6.692230e-04  7.000346e-04  7.322151e-04
## ASV0722     -1.315546e-05 -1.368743e-05 -1.423816e-05 -1.480823e-05
## ASV12660    -2.973845e-04 -3.105571e-04 -3.242677e-04 -3.385344e-04
## ASV0223     -1.110111e-05 -1.153965e-05 -1.199132e-05 -1.245610e-05
## ASV0229      2.872893e-04  3.007311e-04  3.147898e-04  3.294926e-04
## ASV0877     -1.133822e-04 -1.184905e-04 -1.238118e-04 -1.293531e-04
## ASV0983      5.835841e-04  6.099446e-04  6.374295e-04  6.660807e-04
## ASV0626     -1.870906e-04 -1.948269e-04 -2.028275e-04 -2.110960e-04
## ASV4146     -3.362873e-05 -3.518031e-05 -3.680047e-05 -3.849196e-05
## ASV4175     -3.582936e-04 -3.746733e-04 -3.917686e-04 -4.096079e-04
## ASV2082     -2.624273e-05 -2.770594e-05 -2.926014e-05 -3.091172e-05
## ASV2272      2.579204e-04  2.698213e-04  2.822551e-04  2.952442e-04
## ASV2245     -3.131052e-04 -3.275396e-04 -3.426159e-04 -3.583603e-04
## ASV0590     -1.916981e-04 -2.009826e-04 -2.107231e-04 -2.209423e-04
## ASV0217     -2.816849e-04 -2.930920e-04 -3.048653e-04 -3.170078e-04
## ASV0416      2.873112e-04  2.996990e-04  3.125612e-04  3.259106e-04
## ASV1056      3.510546e-04  3.677991e-04  3.853416e-04  4.037198e-04
## ASV7777     -3.131663e-04 -3.276915e-04 -3.428717e-04 -3.587346e-04
## ASV0455      6.325378e-05  6.631757e-05  6.952925e-05  7.289571e-05
## ASV0604      7.246786e-05  7.638809e-05  8.053557e-05  8.492436e-05
## ASV6100     -2.891000e-04 -3.025288e-04 -3.165648e-04 -3.312337e-04
## ASV11359    -3.186490e-04 -3.331071e-04 -3.481868e-04 -3.639116e-04
## ASV6604      2.292300e-04  2.399999e-04  2.512697e-04  2.630620e-04
## ASV5004     -1.886884e-04 -1.973140e-04 -2.063160e-04 -2.157092e-04
## ASV1483     -1.757328e-04 -1.838837e-04 -1.924017e-04 -2.013020e-04
## ASV9773     -3.694011e-04 -3.864886e-04 -4.043420e-04 -4.229936e-04
## ASV4059      3.579266e-05  3.770563e-05  3.972884e-05  4.186921e-05
## ASV1193      5.990345e-04  6.265940e-04  6.553771e-04  6.854340e-04
## ASV4610     -4.957122e-05 -5.127164e-05 -5.299570e-05 -5.473989e-05
## ASV0742     -2.189775e-04 -2.281740e-04 -2.376988e-04 -2.475585e-04
## ASV1502     -5.392581e-06 -5.921399e-06 -6.498513e-06 -7.128046e-06
## ASV0195     -6.847411e-05 -7.200181e-05 -7.571973e-05 -7.963853e-05
## ASV1213      1.872550e-04  1.954230e-04  2.039118e-04  2.127308e-04
## ASV1648     -2.734735e-04 -2.860977e-04 -2.992859e-04 -3.130616e-04
## ASV6984     -2.044450e-04 -2.139165e-04 -2.238137e-04 -2.341546e-04
## ASV0396     -1.418839e-04 -1.470255e-04 -1.522732e-04 -1.576211e-04
## ASV4297      3.035823e-04  3.170292e-04  3.310275e-04  3.455961e-04
## ASV2622      6.948092e-04  7.259649e-04  7.584307e-04  7.922539e-04
## ASV3512      1.079375e-04  1.132941e-04  1.189259e-04  1.248477e-04
## ASV2411      2.409809e-04  2.523489e-04  2.642464e-04  2.766974e-04
## ASV2291     -6.225609e-05 -6.542375e-05 -6.876154e-05 -7.227930e-05
## ASV0807      2.880014e-04  3.020965e-04  3.168916e-04  3.324219e-04
## ASV1292      1.582282e-04  1.653832e-04  1.728447e-04  1.806243e-04
## ASV1035      7.037124e-05  7.324772e-05  7.621971e-05  7.928840e-05
## ASV0070     -1.632422e-04 -1.700974e-04 -1.771961e-04 -1.845430e-04
## ASV0255      6.546493e-05  6.835361e-05  7.135760e-05  7.448026e-05
## ASV0057     -7.124385e-04 -7.437306e-04 -7.762764e-04 -8.101154e-04
## ASV0077     -1.029398e-04 -1.070861e-04 -1.113623e-04 -1.157690e-04
## ASV0625      7.123382e-04  7.440573e-04  7.770872e-04  8.114730e-04
## ASV2464      3.433591e-04  3.584030e-04  3.740473e-04  3.903108e-04
## ASV1315      6.168854e-04  6.454420e-04  6.752894e-04  7.064838e-04
## ASV2673      4.593356e-04  4.811388e-04  5.039732e-04  5.278873e-04
## ASV2161      1.905710e-04  1.997149e-04  2.093004e-04  2.193490e-04
## ASV0337     -3.012363e-04 -3.150092e-04 -3.293857e-04 -3.443901e-04
## ASV7680     -3.551938e-04 -3.716688e-04 -3.888865e-04 -4.068785e-04
## ASV0611      7.729169e-04  8.090790e-04  8.469025e-04  8.864609e-04
## ASV3118     -2.635544e-04 -2.759003e-04 -2.888138e-04 -3.023197e-04
## ASV1284      2.885976e-04  3.024570e-04  3.169740e-04  3.321779e-04
## ASV0889      2.082971e-04  2.177007e-04  2.275071e-04  2.377318e-04
## ASV4649     -2.207783e-04 -2.309903e-04 -2.416600e-04 -2.528067e-04
## ASV1108     -2.843106e-04 -2.979134e-04 -3.121682e-04 -3.271063e-04
## ASV0738     -3.380501e-05 -3.408312e-05 -3.425703e-05 -3.431201e-05
## ASV0473      4.069118e-05  4.245455e-05  4.428629e-05  4.618835e-05
## ASV0598     -3.120573e-04 -3.255951e-04 -3.396597e-04 -3.542661e-04
## ASV0429      5.092411e-04  5.324865e-04  5.567442e-04  5.820537e-04
## ASV1549      5.123664e-04  5.367801e-04  5.623562e-04  5.891498e-04
## ASV1203      3.797510e-04  3.969276e-04  4.148391e-04  4.335134e-04
## ASV4532      1.367853e-05  1.403768e-05  1.438991e-05  1.473311e-05
## ASV0274     -3.771714e-04 -3.935812e-04 -4.106379e-04 -4.283615e-04
## ASV0163     -5.433182e-04 -5.670536e-04 -5.917283e-04 -6.173708e-04
## ASV1298      2.201144e-04  2.296943e-04  2.396506e-04  2.499947e-04
## ASV9424     -4.722755e-04 -4.943420e-04 -5.174192e-04 -5.415516e-04
## ASV0412      7.188292e-04  7.514587e-04  7.854971e-04  8.209990e-04
## ASV0284      3.182694e-04  3.322426e-04  3.467759e-04  3.618869e-04
## ASV0620     -2.471887e-04 -2.591635e-04 -2.717241e-04 -2.848994e-04
## ASV0153     -5.053994e-04 -5.291977e-04 -5.541033e-04 -5.801665e-04
## ASV0498      6.144952e-05  6.520834e-05  6.921417e-05  7.348367e-05
## ASV0097      3.583268e-04  3.751354e-04  3.927234e-04  4.111261e-04
## ASV0104     -1.655962e-03 -1.731660e-03 -1.810680e-03 -1.893154e-03
## ASV1282      2.972537e-04  3.113221e-04  3.260432e-04  3.414454e-04
## ASV3883     -1.694043e-04 -1.774551e-04 -1.858856e-04 -1.947131e-04
## ASV0801      1.723065e-04  1.808095e-04  1.897410e-04  1.991227e-04
## ASV1611     -6.403557e-04 -6.700732e-04 -7.011333e-04 -7.335932e-04
## ASV0227     -2.333658e-04 -2.446337e-04 -2.564495e-04 -2.688400e-04
## ASV0833      2.529858e-04  2.652868e-04  2.781930e-04  2.917343e-04
## ASV0718      5.951477e-04  6.225479e-04  6.511668e-04  6.810548e-04
## ASV1139      2.142215e-04  2.233475e-04  2.328104e-04  2.426177e-04
## ASV0766     -1.632974e-04 -1.706901e-04 -1.783997e-04 -1.864381e-04
## ASV2091      7.843128e-04  8.188527e-04  8.547907e-04  8.921730e-04
## ASV1238     -3.134733e-05 -3.157746e-05 -3.171991e-05 -3.176393e-05
## ASV9193     -9.297736e-05 -9.846139e-05 -1.042837e-04 -1.104649e-04
## ASV0290     -6.456735e-05 -6.770061e-05 -7.098641e-05 -7.443202e-05
## ASV0231      6.296045e-04  6.582991e-04  6.882433e-04  7.194865e-04
## ASV0185      1.257891e-04  1.334993e-04  1.417253e-04  1.505036e-04
## ASV2330      1.816623e-04  1.898043e-04  1.982881e-04  2.071259e-04
## ASV3119     -2.129681e-04 -2.235836e-04 -2.347447e-04 -2.464806e-04
## ASV2368     -2.911033e-04 -3.049289e-04 -3.194088e-04 -3.345735e-04
## ASV0122     -2.240896e-04 -2.339477e-04 -2.442048e-04 -2.548742e-04
## ASV1044      4.024165e-04  4.218967e-04  4.423305e-04  4.637649e-04
## ASV0160     -5.501930e-04 -5.740794e-04 -5.988993e-04 -6.246802e-04
## ASV0326      3.632194e-04  3.799933e-04  3.975181e-04  4.158251e-04
## ASV1388      6.337839e-04  6.627672e-04  6.930209e-04  7.245957e-04
## ASV0792      7.176264e-04  7.500699e-04  7.839002e-04  8.191697e-04
## ASV0036     -4.568190e-04 -4.782140e-04 -5.005939e-04 -5.240024e-04
## ASV2125      7.400477e-04  7.738300e-04  8.090881e-04  8.458807e-04
## ASV1075      1.438477e-04  1.507396e-04  1.579641e-04  1.655375e-04
## ASV0390      1.437091e-04  1.509948e-04  1.586670e-04  1.667475e-04
## ASV3790     -5.946743e-04 -6.221340e-04 -6.508244e-04 -6.807973e-04
## ASV1535     -5.787934e-05 -6.110659e-05 -6.452509e-05 -6.814661e-05
## ASV0263      1.233808e-04  1.290752e-04  1.350231e-04  1.412351e-04
## ASV0675      9.909827e-04  1.037876e-03  1.086966e-03  1.138354e-03
## ASV3348      9.704812e-05  1.018858e-04  1.069740e-04  1.123264e-04
## ASV0058     -9.261006e-04 -9.679467e-04 -1.011585e-03 -1.057083e-03
## ASV4142      2.352198e-04  2.459470e-04  2.571406e-04  2.688190e-04
## ASV0059     -7.968497e-04 -8.327088e-04 -8.700900e-04 -9.090499e-04
## ASV0013     -1.682064e-03 -1.758994e-03 -1.839302e-03 -1.923125e-03
## ASV0033     -4.982609e-04 -5.216767e-04 -5.461779e-04 -5.718131e-04
## ASV4354     -2.164721e-04 -2.262386e-04 -2.364226e-04 -2.470401e-04
## ASV0022     -5.262405e-04 -5.509566e-04 -5.768169e-04 -6.038726e-04
## ASV0134     -1.328994e-04 -1.394588e-04 -1.463501e-04 -1.535906e-04
## ASV0415     -9.993563e-05 -1.035678e-04 -1.072775e-04 -1.110611e-04
## ASV10103    -3.645004e-04 -3.813250e-04 -3.989006e-04 -4.172582e-04
## ASV1613      5.891885e-04  6.158019e-04  6.435513e-04  6.724794e-04
## ASV0135     -2.907224e-05 -2.957543e-05 -3.002227e-05 -3.040304e-05
## ASV0469     -7.348400e-04 -7.679400e-04 -8.024458e-04 -8.384099e-04
## ASV0471      4.844179e-04  5.073961e-04  5.314484e-04  5.566226e-04
## ASV0451     -1.297286e-04 -1.361052e-04 -1.428035e-04 -1.498402e-04
## ASV0747      1.889000e-04  1.982369e-04  2.080436e-04  2.183440e-04
## ASV1314     -2.823763e-04 -2.959855e-04 -3.102561e-04 -3.252205e-04
## ASV0425     -8.271175e-04 -8.636912e-04 -9.017587e-04 -9.413704e-04
## ASV0559     -4.725028e-04 -4.934496e-04 -5.152574e-04 -5.379561e-04
## ASV0148     -5.067963e-04 -5.289311e-04 -5.519432e-04 -5.758595e-04
## ASV0129     -2.445967e-04 -2.545654e-04 -2.648647e-04 -2.754990e-04
## ASV1072      2.399206e-04  2.500905e-04  2.606390e-04  2.715758e-04
## ASV2390      1.793767e-04  1.873463e-04  1.956433e-04  2.042788e-04
## ASV0548      5.392343e-04  5.641727e-04  5.902332e-04  6.174638e-04
## ASV0168     -8.059205e-04 -8.421890e-04 -8.799976e-04 -9.194039e-04
## ASV0066     -6.053393e-04 -6.330653e-04 -6.620112e-04 -6.922261e-04
## ASV0468     -2.219374e-04 -2.320918e-04 -2.426914e-04 -2.537538e-04
## ASV0172     -1.178055e-04 -1.221261e-04 -1.265423e-04 -1.310498e-04
## ASV0236     -2.994877e-04 -3.116324e-04 -3.241727e-04 -3.371126e-04
## ASV0250      3.051267e-05  3.365957e-05  3.710005e-05  4.085935e-05
## ASV0338     -3.363673e-05 -3.409599e-05 -3.448125e-05 -3.478166e-05
## ASV0450     -4.271950e-06 -4.527564e-06 -4.800171e-06 -5.091006e-06
## ASV0377      6.630563e-04  6.935070e-04  7.253049e-04  7.585051e-04
## ASV1022      1.856463e-04  1.942838e-04  2.033143e-04  2.127550e-04
## ASV6174     -4.487080e-05 -4.683500e-05 -4.887794e-05 -5.100221e-05
## ASV0786      7.235741e-05  7.541232e-05  7.857789e-05  8.185646e-05
## ASV0053     -8.025270e-04 -8.396931e-04 -8.785312e-04 -9.191119e-04
## ASV0697     -2.288250e-04 -2.388420e-04 -2.492591e-04 -2.600892e-04
## ASV0785      5.887395e-04  6.156419e-04  6.437283e-04  6.730474e-04
## ASV1967     -3.886644e-04 -4.058640e-04 -4.237669e-04 -4.423969e-04
## ASV0385     -1.748497e-04 -1.821815e-04 -1.897807e-04 -1.976539e-04
## ASV0295      4.910642e-06  5.898525e-06  7.000861e-06  8.228839e-06
## ASV0072     -6.271913e-04 -6.549653e-04 -6.838785e-04 -7.139700e-04
## ASV0157     -2.599268e-04 -2.710818e-04 -2.826563e-04 -2.946605e-04
## ASV0501      3.002212e-04  3.148149e-04  3.301184e-04  3.461655e-04
## ASV10729    -4.891846e-04 -5.119920e-04 -5.358392e-04 -5.607714e-04
## ASV1470      2.089321e-04  2.174147e-04  2.261798e-04  2.352315e-04
## ASV0050     -1.582460e-03 -1.654244e-03 -1.729129e-03 -1.807233e-03
## ASV0411     -3.762374e-05 -3.895462e-05 -4.031246e-05 -4.169604e-05
## ASV0549      3.024446e-04  3.167962e-04  3.318300e-04  3.475787e-04
## ASV0184      1.868990e-04  1.955287e-04  2.045454e-04  2.139657e-04
## ASV0705      2.288219e-04  2.397526e-04  2.512043e-04  2.632015e-04
## ASV1715      5.647540e-04  5.907949e-04  6.179979e-04  6.464115e-04
## ASV0603      6.887051e-05  7.221994e-05  7.573551e-05  7.942577e-05
## ASV0826      1.838640e-04  1.918194e-04  2.000827e-04  2.086627e-04
## ASV0034     -7.144867e-04 -7.465855e-04 -7.800374e-04 -8.148915e-04
## ASV0838      1.564178e-04  1.637260e-04  1.713662e-04  1.793525e-04
## ASV0614     -4.085775e-04 -4.271206e-04 -4.464644e-04 -4.666397e-04
## ASV0014     -1.537573e-03 -1.607548e-03 -1.680565e-03 -1.756745e-03
## ASV0585     -8.947736e-05 -9.331988e-05 -9.730999e-05 -1.014519e-04
## ASV0016     -1.572146e-03 -1.643739e-03 -1.718450e-03 -1.796400e-03
## ASV5394     -4.018512e-04 -4.205031e-04 -4.399977e-04 -4.603707e-04
## ASV0666      3.384581e-04  3.538157e-04  3.698351e-04  3.865419e-04
## ASV2085      1.280544e-04  1.329652e-04  1.380058e-04  1.431736e-04
## ASV0003     -1.436822e-03 -1.502069e-03 -1.570140e-03 -1.641145e-03
## ASV0346     -1.993614e-05 -1.981095e-05 -1.958699e-05 -1.925210e-05
## ASV0267     -2.297648e-04 -2.399129e-04 -2.504697e-04 -2.614481e-04
## ASV0353      3.265631e-04  3.430579e-04  3.604110e-04  3.786680e-04
## ASV2419      4.040094e-04  4.221748e-04  4.411088e-04  4.608395e-04
## ASV0447      1.979112e-04  2.079886e-04  2.186008e-04  2.297772e-04
## ASV0654      6.335212e-04  6.630627e-04  6.939505e-04  7.262432e-04
## ASV0151      1.002250e-04  1.054304e-04  1.109235e-04  1.167216e-04
## ASV0065     -5.742065e-04 -6.000959e-04 -6.270894e-04 -6.552286e-04
## ASV0527      4.219190e-04  4.412520e-04  4.614367e-04  4.825075e-04
## ASV4055     -1.623238e-04 -1.702356e-04 -1.785406e-04 -1.872588e-04
## ASV0166     -4.649045e-04 -4.848915e-04 -5.056458e-04 -5.271892e-04
## ASV0417     -4.073203e-04 -4.256812e-04 -4.448228e-04 -4.647744e-04
## ASV0078     -3.193949e-04 -3.333051e-04 -3.477637e-04 -3.627877e-04
## ASV0322     -3.822946e-04 -3.986837e-04 -4.156995e-04 -4.333598e-04
## ASV0156     -5.012419e-04 -5.231486e-04 -5.459311e-04 -5.696178e-04
## ASV0648     -4.733716e-04 -4.955839e-04 -5.188222e-04 -5.431323e-04
## ASV0407      3.185649e-05  3.336782e-05  3.495522e-05  3.662322e-05
## ASV2030     -9.885648e-05 -1.030656e-04 -1.074333e-04 -1.119638e-04
## ASV0300      2.870853e-04  3.013388e-04  3.163150e-04  3.320510e-04
## ASV1150     -3.524486e-05 -3.664388e-05 -3.808413e-05 -3.956538e-05
## ASV0958      2.901734e-04  3.042292e-04  3.189752e-04  3.344460e-04
## ASV0216     -4.902312e-04 -5.120003e-04 -5.346662e-04 -5.582599e-04
## ASV0446      6.999199e-04  7.334244e-04  7.685311e-04  8.053156e-04
## ASV0367     -2.366090e-04 -2.474672e-04 -2.588057e-04 -2.706444e-04
## ASV0200     -4.335279e-04 -4.532368e-04 -4.738028e-04 -4.952603e-04
## ASV0334     -2.181362e-04 -2.268829e-04 -2.359013e-04 -2.451922e-04
## ASV1311      3.114047e-04  3.256346e-04  3.404876e-04  3.559886e-04
## ASV0458      3.319225e-04  3.469363e-04  3.625940e-04  3.789202e-04
## ASV1371      1.026845e-05  1.077589e-05  1.130898e-05  1.186903e-05
## ASV0418      3.908795e-04  4.080729e-04  4.259629e-04  4.445729e-04
## ASV0004      4.793154e-04  5.010099e-04  5.236353e-04  5.472270e-04
## ASV1943      3.503035e-04  3.659457e-04  3.822415e-04  3.992145e-04
## ASV1495     -9.677039e-05 -1.021175e-04 -1.077834e-04 -1.137886e-04
## ASV0901     -5.560484e-04 -5.821687e-04 -6.094994e-04 -6.380952e-04
## ASV0628      3.215704e-04  3.360042e-04  3.510448e-04  3.667138e-04
## ASV0400      1.331904e-04  1.393592e-04  1.458026e-04  1.525317e-04
## ASV0116     -4.211412e-04 -4.408089e-04 -4.613777e-04 -4.828874e-04
## ASV0788      3.499922e-04  3.660768e-04  3.828739e-04  4.004127e-04
## ASV0117      2.274239e-04  2.383612e-04  2.498290e-04  2.618533e-04
## ASV3137      6.370628e-05  6.668229e-05  6.979541e-05  7.305183e-05
## ASV0001      5.745585e-04  6.000136e-04  6.265141e-04  6.540958e-04
## ASV1651      3.771709e-04  3.935847e-04  4.106450e-04  4.283714e-04
## ASV1692      4.170680e-04  4.368244e-04  4.575102e-04  4.791682e-04
## ASV0660      2.351889e-04  2.453629e-04  2.559252e-04  2.668857e-04
## ASV0508      2.604472e-05  2.691481e-05  2.779517e-05  2.868391e-05
## ASV1660     -1.730896e-04 -1.814807e-04 -1.902822e-04 -1.995143e-04
## ASV0233      9.207577e-05  9.637555e-05  1.008736e-04  1.055789e-04
## ASV1343     -4.197606e-04 -4.393168e-04 -4.597642e-04 -4.811415e-04
## ASV0209      3.856247e-04  4.028073e-04  4.207031e-04  4.393374e-04
## ASV0193     -4.814482e-04 -5.022511e-04 -5.238639e-04 -5.463112e-04
## ASV0357     -3.056520e-05 -3.159897e-05 -3.264385e-05 -3.369709e-05
## ASV0198      1.133080e-04  1.188108e-04  1.245817e-04  1.306336e-04
## ASV0007      5.446402e-04  5.687697e-04  5.938903e-04  6.200362e-04
## ASV1772     -5.430433e-05 -5.664697e-05 -5.907820e-05 -6.160013e-05
## ASV0009      5.134160e-04  5.361087e-04  5.597288e-04  5.843076e-04
## ASV0006      2.055019e-04  2.141727e-04  2.231606e-04  2.324729e-04
## ASV0011     -5.861703e-04 -6.135454e-04 -6.421716e-04 -6.721035e-04
## ASV0015      4.026212e-04  4.208519e-04  4.398649e-04  4.596899e-04
## ASV0017      4.260809e-04  4.453333e-04  4.654084e-04  4.863374e-04
## ASV0235     -3.454796e-04 -3.617203e-04 -3.787104e-04 -3.964829e-04
## ASV0382      7.003320e-05  7.423701e-05  7.871175e-05  8.347541e-05
## ASV2357      5.199984e-04  5.441343e-04  5.693620e-04  5.957284e-04
## ASV0567     -3.710072e-04 -3.876602e-04 -4.050186e-04 -4.231088e-04
## ASV0165      4.175475e-04  4.369901e-04  4.573164e-04  4.785648e-04
## ASV0005      8.228682e-04  8.600373e-04  8.987965e-04  9.392064e-04
## ASV0384     -3.467853e-05 -3.568123e-05 -3.667222e-05 -3.764568e-05
## ASV0002      1.754414e-04  1.836847e-04  1.923089e-04  2.013310e-04
## ASV3017      4.798507e-04  5.013788e-04  5.238141e-04  5.471897e-04
## ASV0091      1.874389e-04  1.962966e-04  2.055692e-04  2.152756e-04
## ASV0186     -4.994864e-04 -5.226250e-04 -5.468049e-04 -5.720702e-04
## ASV0370      5.604440e-05  5.897453e-05  6.206762e-05  6.533344e-05
## ASV0018      8.575829e-04  8.964148e-04  9.369169e-04  9.791535e-04
## ASV1377      7.501590e-04  7.840553e-04  8.193988e-04  8.562437e-04
## ASV0019      8.589524e-04  8.978656e-04  9.384542e-04  9.807830e-04
## ASV0023      5.658464e-05  5.845272e-05  6.033988e-05  6.224162e-05
## ASV2194      2.711828e-04  2.834449e-04  2.962382e-04  3.095844e-04
## ASV1155     -3.079011e-05 -3.188227e-05 -3.299262e-05 -3.411910e-05
## ASV0510     -3.049781e-04 -3.177708e-04 -3.310257e-04 -3.447533e-04
## ASV2371     -3.033071e-04 -3.163774e-04 -3.299495e-04 -3.440377e-04
## ASV0024      1.501161e-05  1.496177e-05  1.484536e-05  1.465428e-05
## ASV2452      3.998592e-04  4.175250e-04  4.359104e-04  4.550396e-04
## ASV2332      1.641584e-05  1.761235e-05  1.890651e-05  2.030679e-05
## ASV2591      2.507361e-05  2.708723e-05  2.926592e-05  3.162283e-05
## ASV0521      5.624858e-04  5.891509e-04  6.170693e-04  6.462986e-04
## ASV5542      1.754249e-04  1.839347e-04  1.928599e-04  2.022207e-04
## ASV0336     -2.448733e-04 -2.554330e-04 -2.664043e-04 -2.777999e-04
## ASV10102     3.894055e-04  4.077225e-04  4.268890e-04  4.469432e-04
## ASV16823    -2.952513e-04 -3.079708e-04 -3.211792e-04 -3.348902e-04
## ASV3104      2.952185e-04  3.079351e-04  3.211404e-04  3.348481e-04
## ASV0781      1.491378e-04  1.560601e-04  1.632949e-04  1.708555e-04
## ASV10899     1.461113e-04  1.535952e-04  1.614796e-04  1.697868e-04
## ASV11222    -2.951979e-04 -3.079129e-04 -3.211164e-04 -3.348223e-04
## ASV11327    -2.951651e-04 -3.078773e-04 -3.210777e-04 -3.347802e-04
## ASV12458    -2.951324e-04 -3.078416e-04 -3.210390e-04 -3.347381e-04
## ASV1636     -2.416903e-04 -2.520874e-04 -2.628823e-04 -2.740858e-04
## ASV1890     -2.953907e-04 -3.082836e-04 -3.216886e-04 -3.356218e-04
## ASV2898      6.485625e-04  6.778807e-04  7.084525e-04  7.403249e-04
## ASV8328     -4.213236e-05 -4.304687e-05 -4.391038e-05 -4.471285e-05
## ASV0709     -5.313823e-04 -5.555290e-04 -5.807192e-04 -6.069931e-04
## ASV0856      8.831200e-05  9.274367e-05  9.740535e-05  1.023094e-04
## ASV0909     -2.168882e-04 -2.257282e-04 -2.348582e-04 -2.442812e-04
## ASV0937     -4.137526e-04 -4.327778e-04 -4.526489e-04 -4.734011e-04
## ASV11390    -2.950637e-04 -3.077671e-04 -3.209581e-04 -3.346504e-04
## ASV11966     1.583585e-04  1.661692e-04  1.743731e-04  1.829905e-04
## ASV12990     8.535953e-05  8.947803e-05  9.379488e-05  9.831936e-05
## ASV14797     3.128991e-04  3.269777e-04  3.416516e-04  3.569425e-04
## ASV14904    -2.950566e-04 -3.077596e-04 -3.209501e-04 -3.346421e-04
## ASV15304     8.674789e-05  9.137857e-05  9.627133e-05  1.014417e-04
## ASV16696    -2.950307e-04 -3.077315e-04 -3.209198e-04 -3.346092e-04
## ASV1690      1.612864e-04  1.693553e-04  1.778387e-04  1.867582e-04
## ASV2029      8.321613e-04  8.699379e-04  9.093448e-04  9.504449e-04
## ASV2834      4.478499e-04  4.684687e-04  4.900049e-04  5.124964e-04
## ASV4003      1.353935e-04  1.425205e-04  1.500445e-04  1.579888e-04
## ASV4064      3.101718e-04  3.244840e-04  3.394345e-04  3.550497e-04
## ASV4294      1.161872e-04  1.223306e-04  1.288196e-04  1.356749e-04
## ASV4609     -1.128882e-05 -1.160526e-05 -1.191815e-05 -1.222589e-05
## ASV6283     -2.950301e-04 -3.077315e-04 -3.209204e-04 -3.346106e-04
## ASV6491     -2.949974e-04 -3.076959e-04 -3.208817e-04 -3.345685e-04
## ASV7453      1.252253e-04  1.316964e-04  1.385173e-04  1.457078e-04
## ASV7959      2.935398e-05  3.141695e-05  3.363416e-05  3.601721e-05
## ASV8219      2.949765e-04  3.076734e-04  3.208576e-04  3.345427e-04
## ASV8547     -2.949438e-04 -3.076379e-04 -3.208189e-04 -3.345007e-04
## ASV9319      2.086322e-04  2.186042e-04  2.290517e-04  2.399972e-04
## ASV9382     -2.949250e-04 -3.076175e-04 -3.207970e-04 -3.344770e-04
## ASV11516    -2.948923e-04 -3.075819e-04 -3.207583e-04 -3.344350e-04
## ASV14377    -2.948595e-04 -3.075464e-04 -3.207196e-04 -3.343930e-04
## ASV1867      4.455986e-04  4.664233e-04  4.882022e-04  5.109775e-04
## ASV1895     -9.964179e-05 -1.038526e-04 -1.082187e-04 -1.127441e-04
## ASV3168      1.896181e-04  1.982324e-04  2.072166e-04  2.165844e-04
## ASV4449      3.699880e-04  3.862636e-04  4.031971e-04  4.208105e-04
## ASV6596      2.231840e-04  2.342535e-04  2.458880e-04  2.581175e-04
## ASV7492     -1.053386e-04 -1.092693e-04 -1.132941e-04 -1.174101e-04
## ASV9854     -1.492538e-04 -1.554585e-04 -1.618816e-04 -1.685273e-04
## ASV6296      2.947936e-04  3.074750e-04  3.206424e-04  3.343096e-04
## ASV4201      1.074365e-04  1.134124e-04  1.197456e-04  1.264590e-04
## ASV0552      7.498818e-04  7.851356e-04  8.220213e-04  8.606118e-04
## ASV3671     -5.527985e-05 -5.708418e-05 -5.890423e-05 -6.073529e-05
## ASV3529     -5.911161e-05 -6.094721e-05 -6.278733e-05 -6.462580e-05
## ASV1060      1.858277e-04  1.944630e-04  2.034900e-04  2.129258e-04
## ASV0239     -4.150564e-04 -4.331687e-04 -4.519939e-04 -4.715531e-04
## ASV5711     -3.818647e-04 -3.986673e-04 -4.161495e-04 -4.343340e-04
## ASV4152     -5.054258e-04 -5.280199e-04 -5.515593e-04 -5.760779e-04
## ASV1461      4.538427e-04  4.739558e-04  4.948913e-04  5.166767e-04
## ASV2877      3.696988e-04  3.863776e-04  4.037655e-04  4.218886e-04
## ASV0012      2.792361e-04  2.923515e-04  3.060725e-04  3.204260e-04
## ASV9823      8.267052e-05  8.553565e-05  8.845443e-05  9.142395e-05
## ASV0008      3.043858e-04  3.185753e-04  3.334108e-04  3.489203e-04
## ASV7832     -3.123766e-04 -3.263071e-04 -3.408187e-04 -3.559322e-04
## ASV1915      2.915594e-05  3.092683e-05  3.281321e-05  3.482278e-05
## ASV0055      2.140838e-04  2.237217e-04  2.337665e-04  2.442330e-04
## ASV0032      5.253612e-04  5.490919e-04  5.738374e-04  5.996363e-04
## ASV2977     -4.238845e-04 -4.427374e-04 -4.623697e-04 -4.828084e-04
## ASV0466      4.281803e-04  4.469225e-04  4.664111e-04  4.866693e-04
## ASV3866      4.629461e-04  4.844722e-04  5.069742e-04  5.304938e-04
## ASV0040      6.125411e-04  6.410546e-04  6.708632e-04  7.020226e-04
## ASV0496     -4.039956e-05 -4.308401e-05 -4.596317e-05 -4.905185e-05
## ASV0052      7.466425e-04  7.806958e-04  8.162340e-04  8.533157e-04
## ASV3828     -4.559958e-04 -4.764667e-04 -4.978039e-04 -5.200399e-04
## ASV1930      2.905081e-04  3.040472e-04  3.182008e-04  3.329949e-04
## ASV2126      4.650529e-04  4.862644e-04  5.083999e-04  5.314957e-04
## ASV0793      2.815261e-04  2.950231e-04  3.091678e-04  3.239908e-04
## ASV0299     -1.940197e-04 -2.023310e-04 -2.109554e-04 -2.199011e-04
## ASV0208      4.450272e-04  4.663490e-04  4.886925e-04  5.121063e-04
## ASV0511     -2.333955e-04 -2.433137e-04 -2.535976e-04 -2.642555e-04
## ASV1123     -3.063421e-04 -3.196315e-04 -3.334388e-04 -3.477793e-04
## ASV0099     -1.633764e-04 -1.703984e-04 -1.776881e-04 -1.852526e-04
## ASV0752     -4.040412e-05 -4.274318e-05 -4.522838e-05 -4.786931e-05
## ASV0883      6.156053e-06  6.661211e-06  7.208326e-06  7.800770e-06
## ASV0683      3.932728e-04  4.119234e-04  4.314524e-04  4.519004e-04
## ASV4117     -4.568098e-04 -4.772358e-04 -4.985175e-04 -5.206859e-04
## ASV2172      1.732850e-04  1.813044e-04  1.896837e-04  1.984381e-04
## ASV0330     -3.080523e-04 -3.220581e-04 -3.366742e-04 -3.519251e-04
## ASV0728      2.980824e-04  3.121085e-04  3.267836e-04  3.421366e-04
## ASV0499      5.937460e-04  6.219261e-04  6.514385e-04  6.823458e-04
## ASV0120     -6.510140e-04 -6.808572e-04 -7.120133e-04 -7.445349e-04
## ASV1446      4.906376e-05  5.069769e-05  5.234790e-05  5.401009e-05
## ASV17171    -4.349586e-04 -4.545136e-04 -4.748977e-04 -4.961418e-04
## ASV0533      1.276856e-04  1.338806e-04  1.403804e-04  1.472002e-04
## ASV2495     -1.793146e-04 -1.877448e-04 -1.965689e-04 -2.058054e-04
## ASV5582      1.510010e-04  1.574030e-04  1.640399e-04  1.709169e-04
## ASV1488      1.634447e-04  1.719922e-04  1.809985e-04  1.904879e-04
## ASV0682      4.164299e-04  4.363278e-04  4.571784e-04  4.790273e-04
## ASV0068     -2.411286e-05 -2.556987e-05 -2.712124e-05 -2.877322e-05
## ASV1987     -2.282419e-04 -2.395469e-04 -2.514267e-04 -2.639114e-04
## ASV0035      7.515080e-05  7.787809e-05  8.065825e-05  8.348711e-05
## ASV7192     -2.902249e-04 -3.028752e-04 -3.160245e-04 -3.296880e-04
## ASV0873      4.046247e-05  4.183061e-05  4.321690e-05  4.461862e-05
## ASV4749      2.086266e-05  2.102151e-05  2.111335e-05  2.112865e-05
## ASV2174      2.605155e-04  2.711738e-04  2.821987e-04  2.935976e-04
## ASV1476     -2.406571e-04 -2.515760e-04 -2.629684e-04 -2.748531e-04
## ASV0740     -5.984628e-04 -6.266362e-04 -6.561187e-04 -6.869693e-04
## ASV0170      1.251258e-04  1.308195e-04  1.367615e-04  1.429616e-04
## ASV2466     -5.378057e-04 -5.623311e-04 -5.879286e-04 -6.146413e-04
## ASV1709      4.141495e-04  4.327392e-04  4.521132e-04  4.723003e-04
## ASV6170     -3.400112e-04 -3.539617e-04 -3.684034e-04 -3.833482e-04
## ASV3673      4.130364e-04  4.310734e-04  4.498392e-04  4.693594e-04
## ASV1745      1.715000e-05  1.731487e-05  1.744102e-05  1.752405e-05
## ASV0380     -2.643427e-04 -2.746600e-04 -2.852934e-04 -2.962464e-04
## ASV0426     -8.432386e-05 -8.765788e-05 -9.109591e-05 -9.463892e-05
## ASV0202     -8.256181e-05 -8.509011e-05 -8.761507e-05 -9.012626e-05
## ASV6350     -3.384391e-04 -3.523401e-04 -3.667325e-04 -3.816283e-04
## ASV0713     -2.601287e-04 -2.721411e-04 -2.846924e-04 -2.978053e-04
## ASV1822      5.971891e-05  6.299990e-05  6.646856e-05  7.013559e-05
## ASV4569      4.074040e-04  4.255488e-04  4.444542e-04  4.641487e-04
## ASV0030     -9.767419e-05 -1.026195e-04 -1.078195e-04 -1.132870e-04
## ASV0331      1.741442e-04  1.827749e-04  1.918444e-04  2.013756e-04
## ASV2981      4.265776e-04  4.468665e-04  4.681097e-04  4.903507e-04
## ASV0828     -2.858088e-04 -2.996278e-04 -3.141175e-04 -3.293103e-04
## ASV2440      6.667385e-04  6.981445e-04  7.310085e-04  7.653960e-04
## ASV3006     -2.689246e-04 -2.794891e-04 -2.903846e-04 -3.016156e-04
## ASV3875     -2.688978e-04 -2.794601e-04 -2.903534e-04 -3.015820e-04
## ASV4511      1.670718e-04  1.751032e-04  1.835230e-04  1.923498e-04
## ASV4700     -2.688712e-04 -2.794314e-04 -2.903225e-04 -3.015487e-04
## ASV5804     -2.688444e-04 -2.794025e-04 -2.902913e-04 -3.015152e-04
## ASV6826      3.085884e-04  3.232857e-04  3.386807e-04  3.548059e-04
## ASV7280      2.705483e-04  2.839358e-04  2.979916e-04  3.127484e-04
## ASV7535     -2.688337e-04 -2.793914e-04 -2.902796e-04 -3.015030e-04
## ASV0651     -2.939002e-04 -3.068201e-04 -3.202565e-04 -3.342254e-04
## ASV0913      4.014563e-04  4.203626e-04  4.401492e-04  4.608561e-04
## ASV10832    -2.688084e-04 -2.793640e-04 -2.902502e-04 -3.014713e-04
## ASV1117     -5.639164e-04 -5.891279e-04 -6.154024e-04 -6.427796e-04
## ASV11329     1.524822e-04  1.609444e-04  1.699025e-04  1.793864e-04
## ASV13209    -1.708087e-06 -3.665347e-07  1.142280e-06  2.832228e-06
## ASV1345      8.372507e-05  8.828210e-05  9.309244e-05  9.816944e-05
## ASV1719     -2.687701e-04 -2.793231e-04 -2.902065e-04 -3.014247e-04
## ASV1886      3.202499e-04  3.344140e-04  3.491665e-04  3.645292e-04
## ASV2158     -5.899640e-05 -6.020330e-05 -6.135008e-05 -6.242695e-05
## ASV2189      3.491599e-04  3.651052e-04  3.817514e-04  3.991272e-04
## ASV2257      2.570461e-04  2.685120e-04  2.804639e-04  2.929210e-04
## ASV2283      2.687107e-04  2.792589e-04  2.901372e-04  3.013499e-04
## ASV2328      2.686839e-04  2.792300e-04  2.901060e-04  3.013163e-04
## ASV2434     -4.137113e-04 -4.316294e-04 -4.502623e-04 -4.696347e-04
## ASV2648      2.686232e-04  2.791643e-04  2.900348e-04  3.012393e-04
## ASV2698      4.117980e-04  4.308567e-04  4.507764e-04  4.715943e-04
## ASV2775      4.840827e-04  5.048784e-04  5.264759e-04  5.488990e-04
## ASV3171      2.685648e-04  2.791011e-04  2.899664e-04  3.011652e-04
## ASV3227      3.581639e-04  3.734075e-04  3.892246e-04  4.056308e-04
## ASV3397      3.444394e-05  3.659973e-05  3.889138e-05  4.132662e-05
## ASV3444      3.974546e-04  4.143921e-04  4.319822e-04  4.502459e-04
## ASV3556      2.684934e-04  2.790238e-04  2.898828e-04  3.010749e-04
## ASV3606     -2.684667e-04 -2.789950e-04 -2.898518e-04 -3.010414e-04
## ASV4190      3.637161e-04  3.804974e-04  3.980340e-04  4.163584e-04
## ASV4197      4.114277e-04  4.290609e-04  4.473767e-04  4.663962e-04
## ASV4722      3.762426e-04  3.932002e-04  4.108852e-04  4.293260e-04
## ASV4765      1.031259e-04  1.083395e-04  1.138142e-04  1.195615e-04
## ASV4809      2.683975e-04  2.789200e-04  2.897706e-04  3.009536e-04
## ASV4846      2.722484e-04  2.850052e-04  2.983444e-04  3.122907e-04
## ASV4903     -5.917851e-05 -6.041896e-05 -6.160264e-05 -6.272001e-05
## ASV4944     -2.683735e-04 -2.788944e-04 -2.897434e-04 -3.009247e-04
## ASV5151     -1.237661e-04 -1.308298e-04 -1.383180e-04 -1.462563e-04
## ASV5413     -2.683563e-04 -2.788762e-04 -2.897240e-04 -3.009042e-04
## ASV5537     -2.683296e-04 -2.788474e-04 -2.896930e-04 -3.008708e-04
## ASV5688      2.683029e-04  2.788186e-04  2.896620e-04  3.008374e-04
## ASV5752      1.497517e-04  1.574616e-04  1.655743e-04  1.741099e-04
## ASV6122     -2.682852e-04 -2.787997e-04 -2.896418e-04 -3.008160e-04
## ASV6135      2.682585e-04  2.787709e-04  2.896108e-04  3.007825e-04
## ASV6188     -2.682318e-04 -2.787421e-04 -2.895798e-04 -3.007491e-04
## ASV6216      4.105426e-04  4.281087e-04  4.463534e-04  4.652978e-04
## ASV6242      2.681733e-04  2.786788e-04  2.895112e-04  3.006750e-04
## ASV6383      2.681466e-04  2.786500e-04  2.894802e-04  3.006416e-04
## ASV6781      2.681199e-04  2.786212e-04  2.894492e-04  3.006083e-04
## ASV6799     -2.680932e-04 -2.785925e-04 -2.894183e-04 -3.005749e-04
## ASV7374     -2.680666e-04 -2.785637e-04 -2.893873e-04 -3.005416e-04
## ASV7539     -2.680399e-04 -2.785350e-04 -2.893563e-04 -3.005082e-04
## ASV8591     -2.680133e-04 -2.785062e-04 -2.893253e-04 -3.004749e-04
## ASV8637      2.679866e-04  2.784775e-04  2.892944e-04  3.004415e-04
## ASV12796    -2.679600e-04 -2.784488e-04 -2.892634e-04 -3.004082e-04
## ASV1934      3.296842e-04  3.449615e-04  3.609282e-04  3.776136e-04
## ASV22549     3.256740e-05  3.547489e-05  3.861960e-05  4.201851e-05
## ASV29857    -2.679365e-04 -2.784237e-04 -2.892367e-04 -3.003798e-04
## ASV3215      4.039298e-04  4.230104e-04  4.429864e-04  4.638994e-04
## ASV3236     -2.679079e-04 -2.783928e-04 -2.892033e-04 -3.003438e-04
## ASV3954     -2.678812e-04 -2.783641e-04 -2.891724e-04 -3.003105e-04
## ASV4850      2.678546e-04  2.783354e-04  2.891415e-04  3.002772e-04
## ASV5225      2.678280e-04  2.783067e-04  2.891106e-04  3.002439e-04
## ASV5532     -2.678014e-04 -2.782780e-04 -2.890796e-04 -3.002106e-04
## ASV7258      4.915557e-05  5.314027e-05  5.744064e-05  6.207993e-05
## ASV9474     -1.436163e-04 -1.484056e-04 -1.532682e-04 -1.581979e-04
## ASV11857    -2.677698e-04 -2.782445e-04 -2.890442e-04 -3.001731e-04
## ASV1202     -2.677432e-04 -2.782158e-04 -2.890133e-04 -3.001398e-04
## ASV14742     2.117518e-04  2.226008e-04  2.340240e-04  2.460522e-04
## ASV16652     1.116691e-04  1.174071e-04  1.234394e-04  1.297798e-04
## ASV2019      4.091743e-04  4.269664e-04  4.454692e-04  4.647066e-04
## ASV2410     -3.873959e-04 -4.050138e-04 -4.234046e-04 -4.426006e-04
## ASV2718      4.210237e-04  4.412419e-04  4.624265e-04  4.846224e-04
## ASV2738      4.595604e-04  4.791686e-04  4.995217e-04  5.206408e-04
## ASV2876      2.676846e-04  2.781527e-04  2.889453e-04  3.000666e-04
## ASV3177      2.676581e-04  2.781240e-04  2.889144e-04  3.000334e-04
## ASV4367      2.676315e-04  2.780954e-04  2.888835e-04  3.000001e-04
## ASV4635      1.119286e-04  1.185684e-04  1.256175e-04  1.331003e-04
## ASV4896      3.871453e-05  4.228952e-05  4.616834e-05  5.037430e-05
## ASV4907      2.236249e-04  2.353617e-04  2.477366e-04  2.607846e-04
## ASV5230     -2.676393e-04 -2.781049e-04 -2.888950e-04 -3.000140e-04
## ASV6509     -2.676127e-04 -2.780762e-04 -2.888642e-04 -2.999807e-04
## ASV7376     -2.675861e-04 -2.780476e-04 -2.888333e-04 -2.999475e-04
## ASV8163     -2.675595e-04 -2.780189e-04 -2.888024e-04 -2.999143e-04
## ASV8195     -2.675330e-04 -2.779903e-04 -2.887716e-04 -2.998810e-04
## ASV8923      1.835678e-04  1.928894e-04  2.026928e-04  2.130025e-04
## ASV9666     -2.346482e-04 -2.435576e-04 -2.527190e-04 -2.621330e-04
## ASV1482      2.675276e-04  2.803105e-04  2.936992e-04  3.077217e-04
## ASV2726      3.478506e-04  3.645997e-04  3.821523e-04  4.005456e-04
## ASV3281     -2.675089e-04 -2.779648e-04 -2.887448e-04 -2.998528e-04
## ASV4235     -2.674823e-04 -2.779362e-04 -2.887139e-04 -2.998196e-04
## ASV4808      4.142436e-04  4.321728e-04  4.508142e-04  4.701921e-04
## ASV4861     -4.129183e-04 -4.307729e-04 -4.493382e-04 -4.686386e-04
## ASV5276      4.092666e-04  4.269251e-04  4.452776e-04  4.643465e-04
## ASV5837      3.593296e-04  3.761052e-04  3.936527e-04  4.120071e-04
## ASV7098      3.663264e-04  3.833278e-04  4.011032e-04  4.196868e-04
## ASV8451     -2.673515e-04 -2.777941e-04 -2.885597e-04 -2.996524e-04
## ASV8694     -2.673249e-04 -2.777655e-04 -2.885289e-04 -2.996192e-04
## ASV0905     -1.559329e-04 -1.633239e-04 -1.710491e-04 -1.791211e-04
## ASV2900      3.328701e-04  3.464434e-04  3.604884e-04  3.750160e-04
## ASV3963     -2.592912e-04 -2.693520e-04 -2.797178e-04 -2.903920e-04
## ASV0041     -3.207126e-04 -3.361808e-04 -3.523943e-04 -3.693883e-04
## ASV1865      3.281307e-04  3.445870e-04  3.618847e-04  3.800669e-04
## ASV1140      2.658790e-04  2.787548e-04  2.922461e-04  3.063804e-04
## ASV1179      3.764858e-04  3.941986e-04  4.127306e-04  4.321177e-04
## ASV0279      5.203525e-04  5.437081e-04  5.680590e-04  5.934436e-04
## ASV0043     -5.197981e-05 -5.523225e-05 -5.870947e-05 -6.242817e-05
## ASV2097     -2.844565e-04 -2.966084e-04 -3.092328e-04 -3.223455e-04
## ASV0309     -1.430597e-04 -1.491133e-04 -1.553918e-04 -1.619011e-04
## ASV0607      6.422204e-04  6.723362e-04  7.038397e-04  7.367923e-04
## ASV0025     -6.812996e-04 -7.134672e-04 -7.471309e-04 -7.823575e-04
## ASV2284     -9.846963e-05 -1.017789e-04 -1.051383e-04 -1.085430e-04
## ASV0556      1.215931e-04  1.280350e-04  1.348342e-04  1.420109e-04
## ASV5040      2.208796e-04  2.291491e-04  2.376416e-04  2.463568e-04
## ASV2924     -2.382015e-04 -2.473224e-04 -2.567094e-04 -2.663641e-04
## ASV1331      8.179665e-04  8.553716e-04  8.944244e-04  9.351925e-04
## ASV0506     -3.644426e-04 -3.799503e-04 -3.960403e-04 -4.127281e-04
## ASV1514      6.152005e-04  6.434893e-04  6.730296e-04  7.038724e-04
## ASV2144      5.154304e-04  5.388770e-04  5.633459e-04  5.888781e-04
## ASV2265      6.866506e-04  7.181934e-04  7.511336e-04  7.855287e-04
## ASV5156      1.398039e-04  1.451316e-04  1.506085e-04  1.562346e-04
## ASV5534      1.100470e-04  1.138411e-04  1.177019e-04  1.216248e-04
## ASV5747     -3.293880e-05 -3.581247e-05 -3.892179e-05 -4.228418e-05
## ASV6657      3.044746e-04  3.177245e-04  3.315028e-04  3.458270e-04
## ASV0658     -3.404418e-04 -3.549134e-04 -3.699283e-04 -3.855014e-04
## ASV0716      8.693934e-05  9.070093e-05  9.460862e-05  9.866670e-05
## ASV1657      1.404050e-04  1.456501e-04  1.510305e-04  1.565449e-04
## ASV1885     -1.757617e-05 -1.964030e-05 -2.189601e-05 -2.435834e-05
## ASV2333      7.492065e-04  7.828380e-04  8.178932e-04  8.544252e-04
## ASV3375      2.716452e-04  2.831045e-04  2.949906e-04  3.073152e-04
## ASV4317      2.931341e-04  3.066466e-04  3.207684e-04  3.355261e-04
## ASV9599     -3.304649e-05 -3.592905e-05 -3.904795e-05 -4.242062e-05
## ASV0175     -1.007314e-03 -1.052456e-03 -1.099492e-03 -1.148491e-03
## ASV1032      2.918610e-04  3.041263e-04  3.168419e-04  3.300196e-04
## ASV1235      2.027722e-06  1.233021e-06  3.309532e-07 -6.882023e-07
## ASV1262      8.889337e-04  9.291081e-04  9.710042e-04  1.014688e-03
## ASV1320      2.270298e-04  2.385935e-04  2.507662e-04  2.635807e-04
## ASV13797     3.248240e-04  3.390884e-04  3.539344e-04  3.693827e-04
## ASV1491      1.795853e-04  1.890156e-04  1.989564e-04  2.094351e-04
## ASV15014    -3.308633e-05 -3.597159e-05 -3.909330e-05 -4.246890e-05
## ASV1510      2.782049e-04  2.918726e-04  3.062137e-04  3.212603e-04
## ASV1551     -1.090789e-04 -1.138767e-04 -1.188688e-04 -1.240618e-04
## ASV1919     -6.994247e-06 -5.958413e-06 -4.768454e-06 -3.410300e-06
## ASV2114      1.562906e-04  1.626682e-04  1.692694e-04  1.760998e-04
## ASV21486    -3.306378e-05 -3.594608e-05 -3.906446e-05 -4.243632e-05
## ASV2448      4.501856e-04  4.699623e-04  4.905410e-04  5.119490e-04
## ASV2589      2.111441e-04  2.200327e-04  2.292509e-04  2.388080e-04
## ASV2608      3.600814e-04  3.761009e-04  3.927899e-04  4.101732e-04
## ASV2786      2.893843e-04  3.024320e-04  3.160441e-04  3.302436e-04
## ASV2827      3.791491e-04  3.961349e-04  4.138380e-04  4.322850e-04
## ASV2872      3.026010e-04  3.153555e-04  3.285786e-04  3.422819e-04
## ASV3125      3.609022e-04  3.763937e-04  3.924833e-04  4.091888e-04
## ASV3247      3.941471e-04  4.112000e-04  4.289207e-04  4.473298e-04
## ASV3451     -3.322665e-05 -3.612317e-05 -3.925695e-05 -4.264546e-05
## ASV3465     -5.653338e-05 -6.042967e-05 -6.460374e-05 -6.907475e-05
## ASV3809      2.247349e-04  2.340737e-04  2.437455e-04  2.537577e-04
## ASV4006      4.911920e-04  5.123992e-04  5.344299e-04  5.573084e-04
## ASV4046      3.475700e-04  3.624541e-04  3.779096e-04  3.939535e-04
## ASV4938     -3.555039e-05 -3.855732e-05 -4.180665e-05 -4.531609e-05
## ASV5435     -3.327006e-05 -3.616942e-05 -3.930614e-05 -4.269771e-05
## ASV5605      1.377308e-04  1.428742e-04  1.481502e-04  1.535572e-04
## ASV5635     -3.327428e-05 -3.617354e-05 -3.931009e-05 -4.270140e-05
## ASV5743      4.430890e-04  4.625793e-04  4.828645e-04  5.039725e-04
## ASV6627     -3.330061e-05 -3.620192e-05 -3.934067e-05 -4.273433e-05
## ASV6785     -3.329341e-05 -3.619376e-05 -3.933143e-05 -4.272386e-05
## ASV7368      4.882720e-04  5.106274e-04  5.339725e-04  5.583485e-04
## ASV9118      1.299540e-04  1.348832e-04  1.399498e-04  1.451540e-04
## ASV9135      9.855167e-05  1.018354e-04  1.051656e-04  1.085371e-04
## ASV9435      2.265704e-04  2.355748e-04  2.448606e-04  2.544302e-04
## ASV9671     -3.334059e-05 -3.624449e-05 -3.938591e-05 -4.278233e-05
## ASV0387     -4.881588e-04 -5.091866e-04 -5.310271e-04 -5.537043e-04
## ASV0454     -4.876438e-04 -5.089546e-04 -5.311147e-04 -5.541512e-04
## ASV0751     -3.161375e-04 -3.295566e-04 -3.434771e-04 -3.579121e-04
## ASV1081      1.335683e-04  1.397379e-04  1.461800e-04  1.529053e-04
## ASV1332      2.681762e-04  2.801296e-04  2.925780e-04  3.055385e-04
## ASV2659      4.323405e-04  4.523351e-04  4.732181e-04  4.950252e-04
## ASV2979      4.402430e-04  4.590641e-04  4.785989e-04  4.988672e-04
## ASV4184      1.727040e-04  1.791016e-04  1.856559e-04  1.923637e-04
## ASV6198      1.538031e-04  1.602877e-04  1.670164e-04  1.739968e-04
## ASV7454      2.862714e-04  2.985166e-04  3.112268e-04  3.244147e-04
## ASV8198      1.083166e-04  1.118543e-04  1.154319e-04  1.190423e-04
## ASV0855      6.501196e-04  6.799094e-04  7.110137e-04  7.434860e-04
## ASV10092     2.711087e-04  2.827658e-04  2.948776e-04  3.074587e-04
## ASV1532      3.632146e-04  3.806715e-04  3.989714e-04  4.181554e-04
## ASV2553      8.626691e-04  9.021298e-04  9.433260e-04  9.863281e-04
## ASV2741      3.542497e-04  3.713666e-04  3.893097e-04  4.081178e-04
## ASV4095      1.981485e-04  2.083837e-04  2.191607e-04  2.305078e-04
## ASV5295      2.446379e-04  2.544522e-04  2.645840e-04  2.750373e-04
## ASV5787     -3.344774e-05 -3.635958e-05 -3.950942e-05 -4.291474e-05
## ASV9455      3.305993e-04  3.449393e-04  3.598486e-04  3.753459e-04
## ASV10879     3.457779e-04  3.612442e-04  3.773668e-04  3.941712e-04
## ASV3997      2.472881e-04  2.593207e-04  2.719360e-04  2.851609e-04
## ASV6760      5.960175e-05  6.083675e-05  6.200557e-05  6.309672e-05
## ASV6990      2.464931e-04  2.568834e-04  2.676610e-04  2.788368e-04
## ASV9560      1.511018e-04  1.571126e-04  1.633188e-04  1.697239e-04
## ASV0220      1.435510e-04  1.502191e-04  1.571881e-04  1.644708e-04
## ASV2518      3.416036e-04  3.574804e-04  3.740768e-04  3.914238e-04
## ASV3615      5.291572e-04  5.529255e-04  5.777040e-04  6.035311e-04
## ASV0075      1.216346e-04  1.269183e-04  1.324111e-04  1.381196e-04
## ASV8070      5.602574e-05  5.727240e-05  5.846861e-05  5.960476e-05
## ASV1658      2.484901e-04  2.592508e-04  2.704372e-04  2.820633e-04
## ASV0773      4.097067e-04  4.277714e-04  4.465760e-04  4.661465e-04
## ASV0799      1.509989e-05  1.586338e-05  1.666666e-05  1.751187e-05
## ASV1839     -8.231904e-05 -8.559098e-05 -8.896146e-05 -9.243042e-05
## ASV0265      4.053351e-04  4.253507e-04  4.463732e-04  4.684540e-04
## ASV3741      1.522600e-04  1.588791e-04  1.657574e-04  1.729022e-04
## ASV0847      5.504117e-04  5.754648e-04  6.016066e-04  6.288800e-04
## ASV1026      5.880624e-04  6.146208e-04  6.423140e-04  6.711847e-04
## ASV1222     -1.733363e-04 -1.799383e-04 -1.867273e-04 -1.937035e-04
## ASV0729      8.334506e-05  8.721029e-05  9.124989e-05  9.547127e-05
## ASV0143     -4.437818e-04 -4.630247e-04 -4.830233e-04 -5.038011e-04
## ASV1328      1.354966e-04  1.422588e-04  1.493677e-04  1.568413e-04
## ASV9078     -1.248930e-04 -1.321191e-04 -1.397853e-04 -1.479184e-04
## ASV0027     -6.511078e-04 -6.817938e-04 -7.139016e-04 -7.474941e-04
## ASV0546     -2.743246e-04 -2.859988e-04 -2.981126e-04 -3.106779e-04
## ASV1136      7.152515e-04  7.476210e-04  7.813891e-04  8.166113e-04
## ASV3081      3.389877e-04  3.544868e-04  3.706743e-04  3.875799e-04
## ASV0531      1.557105e-04  1.633503e-04  1.713675e-04  1.797804e-04
## ASV2525      1.958110e-04  2.044160e-04  2.133718e-04  2.226909e-04
## ASV1083     -6.600628e-05 -6.814732e-05 -7.031251e-05 -7.249784e-05
## ASV0424      1.230986e-04  1.285946e-04  1.343205e-04  1.402846e-04
## ASV0644      2.759860e-05  3.000226e-05  3.260256e-05  3.541394e-05
## ASV6007     -3.279652e-05 -3.565535e-05 -3.874841e-05 -4.209300e-05
## ASV0564      1.817603e-04  1.908600e-04  2.004228e-04  2.104719e-04
## ASV1938      1.810696e-04  1.882994e-04  1.957618e-04  2.034601e-04
## ASV6516     -4.368560e-04 -4.567306e-04 -4.774704e-04 -4.991100e-04
## ASV0503     -5.010735e-04 -5.223417e-04 -5.444025e-04 -5.672764e-04
## ASV6913     -5.127867e-04 -5.353584e-04 -5.588597e-04 -5.833247e-04
## ASV0164     -4.047003e-04 -4.238465e-04 -4.438913e-04 -4.648760e-04
## ASV1576      4.841166e-04  5.061297e-04  5.291073e-04  5.530893e-04
## ASV1725      2.465311e-04  2.589534e-04  2.720112e-04  2.857365e-04
## ASV4501      1.963988e-04  2.041765e-04  2.121949e-04  2.204558e-04
## ASV10678    -4.285524e-04 -4.479615e-04 -4.682070e-04 -4.893211e-04
## ASV0944      3.550340e-04  3.718834e-04  3.895276e-04  4.080034e-04
## ASV2292      5.481706e-04  5.725993e-04  5.980455e-04  6.245457e-04
## ASV1090      3.595540e-04  3.759374e-04  3.930383e-04  4.108858e-04
## ASV9117     -1.644918e-04 -1.707856e-04 -1.772604e-04 -1.839168e-04
## ASV0285     -2.278117e-04 -2.397207e-04 -2.522770e-04 -2.655162e-04
## ASV0463     -3.440674e-04 -3.588039e-04 -3.741007e-04 -3.899734e-04
## ASV3199      2.964016e-04  3.088707e-04  3.217980e-04  3.351953e-04
## ASV0150     -1.285717e-04 -1.350925e-04 -1.419518e-04 -1.491674e-04
## ASV6583     -1.674346e-04 -1.740405e-04 -1.808583e-04 -1.878919e-04
## ASV0392      2.845538e-04  2.974616e-04  3.109271e-04  3.249719e-04
## ASV14007    -3.440738e-04 -3.592838e-04 -3.751146e-04 -3.915869e-04
## ASV0177     -1.868204e-04 -1.945899e-04 -2.026331e-04 -2.109553e-04
## ASV6448     -1.608660e-04 -1.697369e-04 -1.791199e-04 -1.890446e-04
## ASV5399     -7.025772e-05 -7.482667e-05 -7.970485e-05 -8.491258e-05
## ASV0277     -7.223926e-05 -7.562478e-05 -7.916418e-05 -8.286379e-05
## ASV2599      1.232900e-04  1.278480e-04  1.325218e-04  1.373103e-04
## ASV13465    -9.580452e-05 -9.899682e-05 -1.022361e-04 -1.055178e-04
## ASV2412      1.812496e-04  1.896184e-04  1.983628e-04  2.074988e-04
## ASV0423      3.590094e-04  3.764513e-04  3.947510e-04  4.139513e-04
## ASV5187      2.076853e-04  2.157365e-04  2.240300e-04  2.325681e-04
## ASV0701     -8.495858e-04 -8.892347e-04 -9.306951e-04 -9.740461e-04
## ASV4248      2.126509e-04  2.234904e-04  2.348955e-04  2.468956e-04
## ASV0519      3.573033e-04  3.744003e-04  3.923098e-04  4.110693e-04
## ASV0764      6.248007e-05  6.590712e-05  6.953321e-05  7.337027e-05
## ASV5385     -4.425075e-04 -4.631315e-04 -4.846983e-04 -5.072496e-04
## ASV3021     -2.462030e-04 -2.562424e-04 -2.666288e-04 -2.773698e-04
## ASV4119     -1.333653e-04 -1.384955e-04 -1.437768e-04 -1.492102e-04
## ASV2534      6.526624e-05  6.786844e-05  7.055629e-05  7.333138e-05
## ASV1061      3.433261e-04  3.606756e-04  3.789321e-04  3.981447e-04
## ASV0670      4.731927e-04  4.953109e-04  5.184450e-04  5.426400e-04
## ASV1384      2.093105e-04  2.198894e-04  2.310121e-04  2.427060e-04
## ASV1981      4.438550e-04  4.649072e-04  4.869473e-04  5.100201e-04
## ASV9632     -1.277743e-04 -1.319578e-04 -1.361958e-04 -1.404816e-04
## ASV4564      1.093470e-04  1.145779e-04  1.200575e-04  1.257972e-04
## ASV5289     -1.025578e-04 -1.075207e-04 -1.127282e-04 -1.181929e-04
## ASV0516      8.925179e-04  9.338367e-04  9.770094e-04  1.022114e-03
## ASV1463     -3.201650e-04 -3.344072e-04 -3.492388e-04 -3.646805e-04
## ASV0969      1.476808e-04  1.540748e-04  1.607164e-04  1.676126e-04
## ASV1113     -4.150278e-04 -4.342004e-04 -4.542317e-04 -4.751577e-04
## ASV1234     -2.599361e-05 -2.862137e-05 -3.149642e-05 -3.464059e-05
## ASV3814      4.547914e-05  4.582257e-05  4.604524e-05  4.613281e-05
## ASV1000      4.221440e-04  4.410692e-04  4.607899e-04  4.813349e-04
## ASV0079     -3.925991e-05 -4.170225e-05 -4.430894e-05 -4.709151e-05
## ASV0145      1.368053e-04  1.423365e-04  1.480534e-04  1.539594e-04
## ASV0457     -5.346834e-04 -5.585880e-04 -5.834923e-04 -6.094319e-04
## ASV1485      1.758470e-04  1.842976e-04  1.931573e-04  2.024462e-04
## ASV0535     -1.092529e-04 -1.137261e-04 -1.183549e-04 -1.231426e-04
## ASV0259     -3.525558e-04 -3.687140e-04 -3.855811e-04 -4.031851e-04
## ASV0570      2.805299e-05  2.995774e-05  3.199977e-05  3.418902e-05
## ASV0906      4.501009e-04  4.702004e-04  4.911400e-04  5.129501e-04
## ASV1748     -2.754287e-04 -2.893836e-04 -3.040629e-04 -3.195041e-04
## ASV5520     -1.659869e-04 -1.749773e-04 -1.844753e-04 -1.945095e-04
## ASV2288     -5.322949e-04 -5.562962e-04 -5.813203e-04 -6.074056e-04
## ASV1887     -1.094435e-04 -1.156909e-04 -1.223050e-04 -1.293064e-04
## ASV0374     -1.597139e-04 -1.664024e-04 -1.733321e-04 -1.805084e-04
## ASV0823      5.038912e-04  5.259604e-04  5.489205e-04  5.728018e-04
## ASV0717      2.564147e-04  2.682909e-04  2.807005e-04  2.936661e-04
## ASV0431      1.815333e-04  1.897473e-04  1.983150e-04  2.072503e-04
## ASV1030      7.541857e-04  7.902348e-04  8.280012e-04  8.675653e-04
## ASV1082     -1.101990e-04 -1.153334e-04 -1.207004e-04 -1.263098e-04
## ASV2684      7.731858e-05  8.193759e-05  8.684146e-05  9.204699e-05
## ASV0051      6.567991e-04  6.872889e-04  7.191604e-04  7.524736e-04
## ASV0513      3.351127e-05  3.546519e-05  3.754394e-05  3.975611e-05
## ASV0581      8.476280e-04  8.871711e-04  9.285190e-04  9.717504e-04
## ASV7282      1.484644e-04  1.561449e-04  1.642409e-04  1.727760e-04
## ASV3009     -4.629032e-04 -4.843104e-04 -5.066776e-04 -5.300451e-04
## ASV2106     -2.290318e-04 -2.387996e-04 -2.489441e-04 -2.594772e-04
## ASV1012      1.524337e-04  1.600901e-04  1.681356e-04  1.765895e-04
## ASV0921     -8.459429e-06 -8.585078e-06 -8.690658e-06 -8.772813e-06
## ASV0010     -6.616852e-04 -6.928885e-04 -7.255401e-04 -7.597044e-04
## ASV1178      1.797814e-05  1.922073e-05  2.055106e-05  2.197497e-05
## ASV2848     -3.473005e-04 -3.626553e-04 -3.786484e-04 -3.953039e-04
## ASV0586      9.611447e-04  1.006117e-03  1.053154e-03  1.102348e-03
## ASV4225      5.841704e-05  6.282446e-05  6.756135e-05  7.265048e-05
## ASV2156     -4.020442e-04 -4.208662e-04 -4.405536e-04 -4.611444e-04
## ASV9778     -2.510789e-04 -2.625117e-04 -2.744429e-04 -2.868925e-04
## ASV0493     -5.470564e-04 -5.713785e-04 -5.967103e-04 -6.230879e-04
## ASV3770      8.498106e-05  8.783718e-05  9.073956e-05  9.368476e-05
## ASV0470      6.761615e-04  7.072668e-04  7.397550e-04  7.736835e-04
## ASV0262     -2.924954e-04 -3.073567e-04 -3.229938e-04 -3.394476e-04
## ASV0998      4.173592e-04  4.368926e-04  4.573248e-04  4.786956e-04
## ASV7708     -1.071914e-04 -1.116675e-04 -1.163016e-04 -1.210968e-04
## ASV0453     -1.132295e-05 -1.170468e-05 -1.209707e-05 -1.250077e-05
## ASV0044      8.479792e-04  8.869399e-04  9.276270e-04  9.701114e-04
## ASV5490      1.330663e-04  1.388962e-04  1.449570e-04  1.512557e-04
## ASV2638      4.703936e-05  4.985467e-05  5.284580e-05  5.602344e-05
## ASV0829     -7.052691e-05 -7.303306e-05 -7.559339e-05 -7.820628e-05
## ASV0601      1.568014e-04  1.643870e-04  1.723431e-04  1.806880e-04
## ASV0234      3.758162e-04  3.932827e-04  4.115417e-04  4.306278e-04
## ASV0133      4.862525e-04  5.086416e-04  5.320261e-04  5.564469e-04
## ASV0323      5.209014e-04  5.456516e-04  5.715751e-04  5.987271e-04
## ASV0854     -4.091375e-05 -4.259709e-05 -4.433760e-05 -4.613614e-05
## ASV0110      6.526330e-04  6.830231e-04  7.147966e-04  7.480136e-04
## ASV0816      3.503641e-05  3.653479e-05  3.809051e-05  3.970526e-05
## ASV1031     -9.554881e-05 -9.942383e-05 -1.034303e-04 -1.075710e-04
## ASV0144     -2.687594e-04 -2.811086e-04 -2.940064e-04 -3.074758e-04
## ASV0020     -1.236491e-04 -1.301886e-04 -1.370998e-04 -1.444057e-04
## ASV0962     -2.189853e-04 -2.290221e-04 -2.394995e-04 -2.504349e-04
## ASV0794      4.397121e-04  4.612160e-04  4.837803e-04  5.074567e-04
## ASV7117     -2.155122e-04 -2.251693e-04 -2.352337e-04 -2.457206e-04
## ASV1008     -1.615509e-04 -1.694324e-04 -1.777041e-04 -1.863854e-04
## ASV0096      7.022211e-04  7.349034e-04  7.690717e-04  8.047902e-04
## ASV0128     -4.268718e-04 -4.476591e-04 -4.694767e-04 -4.923773e-04
## ASV5232      3.325774e-04  3.487263e-04  3.656638e-04  3.834282e-04
## ASV0031      2.346590e-05  2.431767e-05  2.518765e-05  2.607499e-05
## ASV1744     -4.254821e-05 -4.441836e-05 -4.637214e-05 -4.841410e-05
## ASV0289      3.923630e-04  4.105984e-04  4.296650e-04  4.495995e-04
## ASV7413     -1.006958e-04 -1.067927e-04 -1.132801e-04 -1.201831e-04
## ASV0822     -4.683345e-04 -4.889968e-04 -5.104983e-04 -5.328669e-04
## ASV8111     -4.104203e-04 -4.285202e-04 -4.473678e-04 -4.669907e-04
## ASV0687      3.034709e-04  3.181976e-04  3.336409e-04  3.498349e-04
## ASV0112      1.050475e-04  1.093862e-04  1.138737e-04  1.185122e-04
## ASV0987      2.447543e-04  2.567176e-04  2.692778e-04  2.824657e-04
## ASV5332     -1.151985e-04 -1.193405e-04 -1.235843e-04 -1.279294e-04
## ASV1129     -3.094309e-04 -3.238084e-04 -3.388416e-04 -3.545594e-04
## ASV1274     -1.001295e-04 -1.047231e-04 -1.095197e-04 -1.145279e-04
## ASV0119      5.720482e-04  5.986342e-04  6.264256e-04  6.554745e-04
## ASV0890      1.422472e-04  1.489272e-04  1.559138e-04  1.632203e-04
## ASV0848      8.325207e-04  8.714146e-04  9.120890e-04  9.546220e-04
## ASV5944     -4.489677e-04 -4.694707e-04 -4.908724e-04 -5.132090e-04
## ASV19741    -4.274168e-04 -4.468752e-04 -4.671816e-04 -4.883698e-04
## ASV0504     -4.889212e-04 -5.106033e-04 -5.331804e-04 -5.566839e-04
## ASV2146     -3.124585e-04 -3.261101e-04 -3.403174e-04 -3.551007e-04
## ASV0089     -2.649597e-04 -2.773559e-04 -2.903201e-04 -3.038771e-04
## ASV2301     -2.896674e-04 -3.033402e-04 -3.176515e-04 -3.326305e-04
## ASV2982      1.168891e-04  1.238843e-04  1.313166e-04  1.392128e-04
## ASV0891     -3.603552e-04 -3.768502e-04 -3.940700e-04 -4.120437e-04
## ASV0093      5.893353e-04  6.165128e-04  6.449049e-04  6.745626e-04
## ASV0042      2.856434e-04  2.988246e-04  3.125955e-04  3.269807e-04
## ASV0980      3.880251e-04  4.053686e-04  4.234353e-04  4.422506e-04
## ASV0069     -9.583480e-05 -1.004597e-04 -1.053087e-04 -1.103925e-04
## ASV1364     -6.363935e-05 -6.633953e-05 -6.913871e-05 -7.203910e-05
## ASV0524     -1.140650e-04 -1.196812e-04 -1.255806e-04 -1.317778e-04
## ASV0435      7.870902e-04  8.239922e-04  8.625964e-04  9.029787e-04
## ASV0517     -3.224673e-04 -3.376116e-04 -3.534570e-04 -3.700353e-04
## ASV3167     -1.440703e-04 -1.512570e-04 -1.588099e-04 -1.667480e-04
## ASV4280     -4.662302e-05 -4.855762e-05 -5.056142e-05 -5.263614e-05
## ASV1158      2.000693e-04  2.101703e-04  2.207847e-04  2.319377e-04
## ASV2214      1.401111e-04  1.463096e-04  1.527689e-04  1.594995e-04
## ASV0544     -1.817063e-04 -1.904922e-04 -1.997069e-04 -2.093713e-04
## ASV5326     -3.236930e-05 -3.384742e-05 -3.539180e-05 -3.700546e-05
## ASV3765     -4.674387e-04 -4.890624e-04 -5.116559e-04 -5.352598e-04
## ASV4646     -1.661277e-05 -1.831678e-05 -2.017075e-05 -2.218608e-05
## ASV0090      4.722244e-05  4.909195e-05  5.101643e-05  5.299556e-05
## ASV3680      4.217737e-04  4.399718e-04  4.588730e-04  4.784977e-04
## ASV0111      7.258804e-05  7.566112e-05  7.884607e-05  8.214527e-05
## ASV0768      2.735326e-04  2.866033e-04  3.003005e-04  3.146542e-04
## ASV4862     -1.193757e-05 -1.219130e-05 -1.242809e-05 -1.264454e-05
## ASV1742     -3.435838e-04 -3.584348e-04 -3.738706e-04 -3.899099e-04
## ASV3701     -4.563809e-05 -4.716199e-05 -4.870924e-05 -5.027779e-05
## ASV2386     -2.145058e-04 -2.244061e-04 -2.347479e-04 -2.455493e-04
## ASV0375     -4.937828e-04 -5.158237e-04 -5.387914e-04 -5.627204e-04
## ASV2796      1.248871e-04  1.301187e-04  1.355444e-04  1.411699e-04
## ASV1369      3.391350e-04  3.542704e-04  3.700481e-04  3.864935e-04
## ASV10272    -3.106590e-04 -3.247727e-04 -3.394962e-04 -3.548530e-04
## ASV10354    -3.106225e-04 -3.247329e-04 -3.394527e-04 -3.548055e-04
## ASV1067     -2.344265e-05 -2.449064e-05 -2.558207e-05 -2.671842e-05
## ASV1900      6.547990e-04  6.854676e-04  7.175482e-04  7.511034e-04
## ASV4079     -1.128468e-04 -1.182888e-04 -1.239937e-04 -1.299740e-04
## ASV4149      4.324048e-04  4.512278e-04  4.707921e-04  4.911201e-04
## ASV5140     -3.105862e-04 -3.246931e-04 -3.394092e-04 -3.547579e-04
## ASV10782    -9.709957e-06 -9.725131e-06 -9.700409e-06 -9.630351e-06
## ASV4273     -6.990206e-05 -7.276056e-05 -7.571249e-05 -7.875861e-05
## ASV8121      2.999521e-04  3.139285e-04  3.285434e-04  3.438251e-04
## ASV8438     -3.105550e-04 -3.246593e-04 -3.393724e-04 -3.547179e-04
## ASV9390     -3.105186e-04 -3.246195e-04 -3.393289e-04 -3.546704e-04
## ASV1340      4.342696e-04  4.547584e-04  4.762028e-04  4.986464e-04
## ASV2650     -4.600363e-04 -4.806210e-04 -5.020668e-04 -5.244046e-04
## ASV4674      2.362449e-04  2.471378e-04  2.585160e-04  2.703993e-04
## ASV10492    -1.651554e-05 -1.718138e-05 -1.786888e-05 -1.857835e-05
## ASV11430    -3.104655e-04 -3.245616e-04 -3.392658e-04 -3.546016e-04
## ASV12135    -3.104291e-04 -3.245218e-04 -3.392223e-04 -3.545542e-04
## ASV14970    -3.103927e-04 -3.244820e-04 -3.391789e-04 -3.545067e-04
## ASV1954      3.567108e-04  3.732727e-04  3.905823e-04  4.086714e-04
## ASV2613      5.547111e-04  5.802051e-04  6.068285e-04  6.346275e-04
## ASV2757      2.174316e-04  2.269385e-04  2.368241e-04  2.471001e-04
## ASV2909     -3.309172e-04 -3.465732e-04 -3.629649e-04 -3.801262e-04
## ASV2954     -6.355005e-05 -6.631557e-05 -6.918915e-05 -7.217389e-05
## ASV2969      3.105983e-04  3.254625e-04  3.410396e-04  3.573638e-04
## ASV3410      6.504942e-05  6.834861e-05  7.182262e-05  7.548121e-05
## ASV3575      1.613481e-04  1.687670e-04  1.765164e-04  1.846101e-04
## ASV4275      3.533392e-04  3.690246e-04  3.853549e-04  4.023522e-04
## ASV4652      6.242830e-05  6.565135e-05  6.904928e-05  7.263210e-05
## ASV4761      3.531684e-04  3.688666e-04  3.852104e-04  4.022215e-04
## ASV6003      2.751122e-04  2.884533e-04  3.024505e-04  3.171368e-04
## ASV6110     -3.104718e-04 -3.245687e-04 -3.392739e-04 -3.546108e-04
## ASV7427      2.012195e-04  2.104097e-04  2.200016e-04  2.300111e-04
## ASV8092     -3.104482e-04 -3.245429e-04 -3.392457e-04 -3.545800e-04
## ASV8169     -3.104118e-04 -3.245031e-04 -3.392023e-04 -3.545326e-04
## ASV9693      1.361297e-04  1.424599e-04  1.490767e-04  1.559923e-04
## ASV10913     1.493953e-04  1.565603e-04  1.640700e-04  1.719409e-04
## ASV1979     -4.901951e-05 -5.109980e-05 -5.325745e-05 -5.549441e-05
## ASV3772      3.832704e-04  4.005648e-04  4.185979e-04  4.373979e-04
## ASV0113      7.654649e-05  7.995646e-05  8.350873e-05  8.720850e-05
## ASV1800     -3.035641e-05 -3.168869e-05 -3.307012e-05 -3.450130e-05
## ASV2335     -4.033579e-04 -4.212690e-04 -4.399297e-04 -4.593686e-04
## ASV0692      1.325722e-04  1.387593e-04  1.452279e-04  1.519900e-04
## ASV1120      1.715894e-04  1.796188e-04  1.880175e-04  1.968021e-04
## ASV1434     -9.061722e-04 -9.483899e-04 -9.925319e-04 -1.038682e-03
## ASV0076     -1.006847e-04 -1.055209e-04 -1.105895e-04 -1.159014e-04
## ASV0361      6.781337e-04  7.098050e-04  7.429266e-04  7.775622e-04
## ASV2231     -2.294028e-04 -2.409332e-04 -2.530646e-04 -2.658296e-04
## ASV2018     -9.948746e-06 -1.046964e-05 -1.102042e-05 -1.160307e-05
## ASV1529      5.692893e-04  5.963541e-04  6.247022e-04  6.543939e-04
## ASV0841     -2.667248e-05 -2.763585e-05 -2.861789e-05 -2.961723e-05
## ASV2556     -3.381636e-04 -3.535777e-04 -3.696629e-04 -3.864455e-04
## ASV2777      4.217008e-04  4.399462e-04  4.588996e-04  4.785812e-04
## ASV0355      3.490038e-04  3.652550e-04  3.822468e-04  4.000116e-04
## ASV5169     -4.860869e-04 -5.085584e-04 -5.320357e-04 -5.565609e-04
## ASV3091      2.354976e-04  2.467581e-04  2.585584e-04  2.709245e-04
## ASV2435      3.443793e-04  3.602510e-04  3.768294e-04  3.941437e-04
## ASV6822     -2.167352e-04 -2.264669e-04 -2.366081e-04 -2.471737e-04
## ASV12605    -5.287484e-04 -5.531578e-04 -5.786584e-04 -6.052957e-04
## ASV0286     -3.490787e-04 -3.650556e-04 -3.817416e-04 -3.991668e-04
## ASV0074     -1.696636e-05 -1.828849e-05 -1.971655e-05 -2.125886e-05
## ASV2485     -2.785753e-05 -2.950986e-05 -3.127480e-05 -3.316118e-05
## ASV1233     -6.732628e-04 -7.045929e-04 -7.373507e-04 -7.715985e-04
## ASV0356     -3.175527e-04 -3.318433e-04 -3.467449e-04 -3.622811e-04
## ASV2918     -4.060030e-04 -4.245099e-04 -4.438249e-04 -4.639803e-04
## ASV1427      6.297155e-07  5.145235e-07  3.802822e-07  2.248422e-07
## ASV1409      3.926680e-04  4.113250e-04  4.308655e-04  4.513309e-04
## ASV0770      1.255497e-04  1.309984e-04  1.366585e-04  1.425359e-04
## ASV1403     -4.716751e-04 -4.933395e-04 -5.159630e-04 -5.395846e-04
## ASV0314     -2.561304e-04 -2.679835e-04 -2.803675e-04 -2.933042e-04
## ASV0187      3.136309e-06  2.802314e-06  2.413705e-06  1.965147e-06
## ASV0313     -3.475007e-04 -3.633942e-04 -3.799849e-04 -3.973005e-04
## ASV1087      5.958835e-04  6.235475e-04  6.524634e-04  6.826850e-04
## ASV1970      3.488772e-05  3.646419e-05  3.810918e-05  3.982554e-05
## ASV0754      4.806405e-04  5.030038e-04  5.263837e-04  5.508243e-04
## ASV3775     -3.291616e-04 -3.447412e-04 -3.610530e-04 -3.781307e-04
## ASV0132      1.385156e-04  1.448999e-04  1.515687e-04  1.585338e-04
## ASV2329     -9.572130e-05 -1.009737e-04 -1.065258e-04 -1.123947e-04
## ASV0561      4.157762e-04  4.347982e-04  4.546545e-04  4.753784e-04
## ASV0130     -5.077219e-04 -5.314911e-04 -5.563517e-04 -5.823516e-04
## ASV0226      5.712474e-04  5.977102e-04  6.253642e-04  6.542599e-04
## ASV12648    -3.978153e-04 -4.157211e-04 -4.343975e-04 -4.538754e-04
## ASV0204      5.695086e-04  5.958840e-04  6.234460e-04  6.522448e-04
## ASV0767      1.000397e-04  1.043234e-04  1.087675e-04  1.133759e-04
## ASV0335     -3.109603e-04 -3.254250e-04 -3.405450e-04 -3.563483e-04
## ASV5901     -9.176469e-05 -9.561325e-05 -9.960513e-05 -1.037446e-04
## ASV0596     -1.236766e-04 -1.289931e-04 -1.345114e-04 -1.402367e-04
## ASV9271      1.255116e-04  1.323664e-04  1.396141e-04  1.472775e-04
## ASV0904      5.073693e-04  5.313097e-04  5.563685e-04  5.825966e-04
## ASV15270    -1.435719e-04 -1.511299e-04 -1.590965e-04 -1.674935e-04
## ASV0990     -1.422559e-04 -1.489924e-04 -1.560459e-04 -1.634310e-04
## ASV0155     -3.050041e-04 -3.191482e-04 -3.339311e-04 -3.493801e-04
## ASV0086     -4.437254e-06 -4.658407e-06 -4.890813e-06 -5.135050e-06
## ASV2581     -2.470857e-05 -2.575101e-05 -2.682913e-05 -2.794316e-05
## ASV1579     -3.559369e-04 -3.729199e-04 -3.907116e-04 -4.093499e-04
## ASV7730     -1.755674e-05 -1.903838e-05 -2.063449e-05 -2.235252e-05
## ASV0897      1.502237e-04  1.574410e-04  1.650067e-04  1.729377e-04
## ASV1975      6.899128e-04  7.219609e-04  7.554653e-04  7.904897e-04
##                                                                    
## (Intercept)  1.907454e-06  1.759780e-06  1.529906e-06  1.198670e-06
## ASV1236      3.740398e-04  3.904896e-04  4.076013e-04  4.253960e-04
## ASV0421     -6.720908e-04 -7.021404e-04 -7.334454e-04 -7.660506e-04
## ASV0691     -5.692882e-04 -5.934999e-04 -6.186141e-04 -6.446539e-04
## ASV0899      3.838623e-06  4.890260e-06  6.061246e-06  7.362019e-06
## ASV1004      7.585363e-04  7.922018e-04  8.272487e-04  8.637236e-04
## ASV1041     -5.175121e-04 -5.406863e-04 -5.648289e-04 -5.899741e-04
## ASV1058      7.069126e-04  7.384000e-04  7.711923e-04  8.053351e-04
## ASV12542     2.154352e-04  2.247232e-04  2.343697e-04  2.443850e-04
## ASV1294      8.261038e-04  8.633237e-04  9.021232e-04  9.425606e-04
## ASV13113     3.041241e-04  3.186700e-04  3.339146e-04  3.498919e-04
## ASV1318      7.179672e-04  7.500211e-04  7.834083e-04  8.181754e-04
## ASV2269     -2.150104e-04 -2.246616e-04 -2.347168e-04 -2.451901e-04
## ASV2542      4.692402e-04  4.911968e-04  5.141615e-04  5.381787e-04
## ASV2660     -4.128144e-04 -4.310203e-04 -4.499624e-04 -4.696644e-04
## ASV2737     -2.501772e-05 -2.644359e-05 -2.795402e-05 -2.955394e-05
## ASV2840      5.477449e-04  5.717313e-04  5.966725e-04  6.225981e-04
## ASV3053      2.883055e-05  3.001793e-05  3.124780e-05  3.252128e-05
## ASV3077      1.708862e-04  1.784345e-04  1.862914e-04  1.944676e-04
## ASV3134      6.093664e-04  6.382495e-04  6.684956e-04  7.001685e-04
## ASV3140      2.668888e-04  2.793665e-04  2.924122e-04  3.060501e-04
## ASV3579      1.096376e-04  1.152197e-04  1.211001e-04  1.272958e-04
## ASV6119     -2.149519e-04 -2.245979e-04 -2.346474e-04 -2.451145e-04
## ASV7557     -2.149219e-04 -2.245650e-04 -2.346115e-04 -2.450754e-04
## ASV8422      1.133082e-04  1.180122e-04  1.228835e-04  1.279259e-04
## ASV1086     -5.866693e-05 -6.118199e-05 -6.379430e-05 -6.650684e-05
## ASV1310      4.059454e-04  4.241309e-04  4.430781e-04  4.628139e-04
## ASV15750    -1.012712e-04 -1.057209e-04 -1.103463e-04 -1.151525e-04
## ASV16905    -2.149090e-04 -2.245509e-04 -2.345960e-04 -2.450584e-04
## ASV2033      4.062914e-04  4.252342e-04  4.450408e-04  4.657486e-04
## ASV2089      1.475483e-04  1.542015e-04  1.611352e-04  1.683593e-04
## ASV2127      5.819597e-04  6.078493e-04  6.348091e-04  6.628764e-04
## ASV2725      6.553351e-04  6.839717e-04  7.137452e-04  7.446906e-04
## ASV2804     -2.149013e-04 -2.245426e-04 -2.345870e-04 -2.450487e-04
## ASV3075      4.185818e-04  4.373819e-04  4.569790e-04  4.774033e-04
## ASV3327      3.988438e-04  4.174605e-04  4.369301e-04  4.572902e-04
## ASV3342      4.329576e-04  4.528987e-04  4.737250e-04  4.954728e-04
## ASV3532     -3.922160e-04 -4.103328e-04 -4.292590e-04 -4.490284e-04
## ASV3600      4.918556e-04  5.143024e-04  5.377312e-04  5.621815e-04
## ASV4013      4.117085e-04  4.301633e-04  4.493936e-04  4.694275e-04
## ASV4136      4.045954e-04  4.223507e-04  4.408177e-04  4.600192e-04
## ASV4195      2.148582e-04  2.244956e-04  2.345358e-04  2.449929e-04
## ASV4407     -2.148281e-04 -2.244628e-04 -2.345000e-04 -2.449538e-04
## ASV4717      6.342017e-06  6.236433e-06  6.094752e-06  5.913270e-06
## ASV6794      2.120866e-04  2.209602e-04  2.301538e-04  2.396751e-04
## ASV8324     -2.148170e-04 -2.244505e-04 -2.344864e-04 -2.449387e-04
## ASV8981     -5.654104e-05 -5.879722e-05 -6.112003e-05 -6.350902e-05
## ASV9859      1.708613e-04  1.793400e-04  1.882543e-04  1.976277e-04
## ASV0936     -3.376578e-04 -3.529086e-04 -3.688121e-04 -3.853932e-04
## ASV12683    -3.629137e-05 -3.810463e-05 -4.000834e-05 -4.200675e-05
## ASV1293      4.925397e-04  5.143252e-04  5.369981e-04  5.605880e-04
## ASV13055    -5.156059e-05 -5.373720e-05 -5.598999e-05 -5.831998e-05
## ASV17063    -2.147677e-04 -2.243969e-04 -2.344283e-04 -2.448758e-04
## ASV2228      2.147376e-04  2.243642e-04  2.343925e-04  2.448367e-04
## ASV2769     -3.966146e-05 -4.122747e-05 -4.283837e-05 -4.449374e-05
## ASV2803      9.643882e-05  1.003699e-04  1.044339e-04  1.086331e-04
## ASV2896      2.701668e-04  2.825490e-04  2.954815e-04  3.089877e-04
## ASV3062      8.516038e-05  8.947558e-05  9.401958e-05  9.880520e-05
## ASV3107      3.274993e-04  3.425801e-04  3.583333e-04  3.747869e-04
## ASV3265      6.419927e-04  6.704443e-04  7.000613e-04  7.308829e-04
## ASV3666     -1.483379e-05 -1.553939e-05 -1.627709e-05 -1.704820e-05
## ASV4497      1.529312e-04  1.597805e-04  1.669188e-04  1.743568e-04
## ASV6914     -7.700984e-05 -8.061516e-05 -8.438395e-05 -8.832302e-05
## ASV0576     -7.465647e-04 -7.787002e-04 -8.120695e-04 -8.467072e-04
## ASV0673      2.075022e-04  2.176608e-04  2.283218e-04  2.395097e-04
## ASV0772      2.290678e-04  2.393575e-04  2.500844e-04  2.612650e-04
## ASV0862     -1.837590e-04 -1.916416e-04 -1.998238e-04 -2.083134e-04
## ASV0898      1.952155e-04  2.045917e-04  2.144178e-04  2.247152e-04
## ASV0910      4.202969e-04  4.402070e-04  4.610527e-04  4.828772e-04
## ASV0964     -2.751635e-04 -2.873053e-04 -2.999402e-04 -3.130846e-04
## ASV10059     1.989812e-04  2.085931e-04  2.186762e-04  2.292543e-04
## ASV10263    -2.148998e-04 -2.245414e-04 -2.345861e-04 -2.450482e-04
## ASV1088      2.225889e-04  2.331571e-04  2.442280e-04  2.558257e-04
## ASV1101      3.729738e-04  3.898429e-04  4.074318e-04  4.257672e-04
## ASV1183      2.411620e-04  2.522749e-04  2.638803e-04  2.759984e-04
## ASV11956     8.581555e-05  8.915865e-05  9.260032e-05  9.614082e-05
## ASV12774    -3.461966e-05 -3.636862e-05 -3.820728e-05 -4.014019e-05
## ASV1321      9.981423e-05  1.049897e-04  1.104476e-04  1.162042e-04
## ASV13793    -2.148632e-04 -2.245013e-04 -2.345423e-04 -2.450003e-04
## ASV14482    -2.295261e-05 -2.423385e-05 -2.558861e-05 -2.702096e-05
## ASV15483     1.522936e-04  1.593611e-04  1.667504e-04  1.744754e-04
## ASV2062      9.487153e-04  9.916918e-04  1.036515e-03  1.083255e-03
## ASV2132      4.368945e-04  4.572378e-04  4.785084e-04  5.007467e-04
## ASV2413      6.078061e-04  6.348163e-04  6.629427e-04  6.922241e-04
## ASV2490      3.940687e-04  4.110993e-04  4.287883e-04  4.471543e-04
## ASV2594      2.200815e-04  2.300319e-04  2.404137e-04  2.512444e-04
## ASV2822     -2.149128e-04 -2.245556e-04 -2.346017e-04 -2.450654e-04
## ASV2863      3.702638e-04  3.865767e-04  4.035486e-04  4.212009e-04
## ASV2910      4.816745e-04  5.028323e-04  5.248411e-04  5.477285e-04
## ASV2980      1.766137e-04  1.844606e-04  1.926279e-04  2.011261e-04
## ASV3307      2.148625e-04  2.245007e-04  2.345419e-04  2.450001e-04
## ASV3474      3.414352e-04  3.576040e-04  3.745332e-04  3.922580e-04
## ASV3502      7.021244e-04  7.340774e-04  7.674184e-04  8.022019e-04
## ASV4236      3.527080e-04  3.682495e-04  3.844199e-04  4.012396e-04
## ASV4842     -1.196239e-04 -1.251328e-04 -1.308831e-04 -1.368842e-04
## ASV4894     -2.148974e-04 -2.245389e-04 -2.345837e-04 -2.450459e-04
## ASV5290      2.630056e-04  2.749051e-04  2.873163e-04  3.002590e-04
## ASV5501      4.924027e-05  5.146758e-05  5.379278e-05  5.622008e-05
## ASV5795      1.785604e-04  1.868455e-04  1.955061e-04  2.045585e-04
## ASV5987     -2.149092e-04 -2.245519e-04 -2.345980e-04 -2.450616e-04
## ASV6267     -2.148791e-04 -2.245191e-04 -2.345621e-04 -2.450225e-04
## ASV6862      4.044827e-04  4.218469e-04  4.398745e-04  4.585840e-04
## ASV7145      7.025273e-05  7.303528e-05  7.590546e-05  7.886431e-05
## ASV7673     -2.148692e-04 -2.245082e-04 -2.345501e-04 -2.450093e-04
## ASV7789      8.141918e-05  8.562975e-05  9.007126e-05  9.475730e-05
## ASV7809     -2.615519e-05 -2.709683e-05 -2.805476e-05 -2.902720e-05
## ASV8002     -2.148475e-04 -2.244847e-04 -2.345247e-04 -2.449818e-04
## ASV8205      1.220282e-04  1.274648e-04  1.331305e-04  1.390340e-04
## ASV9155     -1.615269e-04 -1.687252e-04 -1.762195e-04 -1.840194e-04
## ASV9221     -2.712337e-05 -2.822763e-05 -2.936661e-05 -3.054039e-05
## ASV9311     -2.148060e-04 -2.244393e-04 -2.344753e-04 -2.449280e-04
## ASV9557     -2.147759e-04 -2.244065e-04 -2.344395e-04 -2.448889e-04
## ASV9936     -2.147459e-04 -2.243737e-04 -2.344037e-04 -2.448499e-04
## ASV1445      4.994407e-04  5.225069e-04  5.466062e-04  5.717821e-04
## ASV4232      4.223444e-04  4.421298e-04  4.628300e-04  4.844864e-04
## ASV6479      4.782537e-06  5.725400e-06  6.777565e-06  7.949701e-06
## ASV0142     -1.072509e-03 -1.119589e-03 -1.168558e-03 -1.219478e-03
## ASV0378     -3.542239e-04 -3.696984e-04 -3.857841e-04 -4.024995e-04
## ASV1122      6.594940e-04  6.899409e-04  7.217491e-04  7.549756e-04
## ASV0123     -1.050395e-03 -1.096464e-03 -1.144379e-03 -1.194198e-03
## ASV2064      1.022751e-04  1.063702e-04  1.106008e-04  1.149695e-04
## ASV4459     -1.194620e-04 -1.248531e-04 -1.304721e-04 -1.363269e-04
## ASV0448      1.952703e-04  2.050633e-04  2.153621e-04  2.261935e-04
## ASV0397      4.939908e-04  5.166895e-04  5.403921e-04  5.651396e-04
## ASV0485      6.829708e-04  7.137149e-04  7.457646e-04  7.791689e-04
## ASV1566      5.753518e-04  6.016127e-04  6.290197e-04  6.576179e-04
## ASV1365      3.703935e-04  3.872385e-04  4.048145e-04  4.231501e-04
## ASV1065      7.658210e-04  8.009103e-04  8.375433e-04  8.757821e-04
## ASV0722     -1.539821e-05 -1.600872e-05 -1.664039e-05 -1.729392e-05
## ASV12660    -3.533753e-04 -3.688088e-04 -3.848538e-04 -4.015288e-04
## ASV0223     -1.293390e-05 -1.342455e-05 -1.392783e-05 -1.444341e-05
## ASV0229      3.448677e-04  3.609445e-04  3.777536e-04  3.953268e-04
## ASV0877     -1.351215e-04 -1.411243e-04 -1.473685e-04 -1.538613e-04
## ASV0983      6.959413e-04  7.270553e-04  7.594678e-04  7.932249e-04
## ASV0626     -2.196360e-04 -2.284503e-04 -2.375411e-04 -2.469100e-04
## ASV4146     -4.025762e-05 -4.210038e-05 -4.402328e-05 -4.602945e-05
## ASV4175     -4.282200e-04 -4.476348e-04 -4.678830e-04 -4.889961e-04
## ASV2082     -3.266757e-05 -3.453514e-05 -3.652240e-05 -3.863799e-05
## ASV2272      3.088121e-04  3.229829e-04  3.377818e-04  3.532346e-04
## ASV2245     -3.748000e-04 -3.919631e-04 -4.098785e-04 -4.285761e-04
## ASV0590     -2.316641e-04 -2.429138e-04 -2.547177e-04 -2.671037e-04
## ASV0217     -3.295210e-04 -3.424059e-04 -3.556618e-04 -3.692869e-04
## ASV0416      3.397598e-04  3.541214e-04  3.690075e-04  3.844302e-04
## ASV1056      4.229731e-04  4.431428e-04  4.642720e-04  4.864057e-04
## ASV7777     -3.753091e-04 -3.926252e-04 -4.107138e-04 -4.296071e-04
## ASV0455      7.642412e-05  8.012190e-05  8.399678e-05  8.805675e-05
## ASV0604      8.956935e-05  9.448638e-05  9.969228e-05  1.052049e-04
## ASV6100     -3.465624e-04 -3.625788e-04 -3.793117e-04 -3.967910e-04
## ASV11359    -3.803057e-04 -3.973939e-04 -4.152013e-04 -4.337540e-04
## ASV6604      2.754004e-04  2.883096e-04  3.018153e-04  3.159443e-04
## ASV5004     -2.255087e-04 -2.357302e-04 -2.463896e-04 -2.575033e-04
## ASV1483     -2.106008e-04 -2.203147e-04 -2.304609e-04 -2.410570e-04
## ASV9773     -4.424765e-04 -4.628251e-04 -4.840750e-04 -5.062630e-04
## ASV4059      4.413411e-05  4.653141e-05  4.906951e-05  5.175736e-05
## ASV1193      7.168169e-04  7.495796e-04  7.837777e-04  8.194685e-04
## ASV4610     -5.650028e-05 -5.827239e-05 -6.005118e-05 -6.183104e-05
## ASV0742     -2.577590e-04 -2.683060e-04 -2.792045e-04 -2.904591e-04
## ASV1502     -7.814440e-06 -8.562483e-06 -9.377329e-06 -1.026452e-05
## ASV0195     -8.376950e-05 -8.812451e-05 -9.271609e-05 -9.755745e-05
## ASV1213      2.218893e-04  2.313965e-04  2.412617e-04  2.514939e-04
## ASV1648     -3.274491e-04 -3.424736e-04 -3.581611e-04 -3.745388e-04
## ASV6984     -2.449576e-04 -2.562419e-04 -2.680276e-04 -2.803352e-04
## ASV0396     -1.630621e-04 -1.685881e-04 -1.741896e-04 -1.798558e-04
## ASV4297      3.607541e-04  3.765210e-04  3.929167e-04  4.099611e-04
## ASV2622      8.274830e-04  8.641677e-04  9.023584e-04  9.421066e-04
## ASV3512      1.310752e-04  1.376250e-04  1.445147e-04  1.517629e-04
## ASV2411      2.897266e-04  3.033601e-04  3.176249e-04  3.325489e-04
## ASV2291     -7.598749e-05 -7.989722e-05 -8.402030e-05 -8.836927e-05
## ASV0807      3.487241e-04  3.658368e-04  3.838005e-04  4.026574e-04
## ASV1292      1.887340e-04  1.971861e-04  2.059933e-04  2.151686e-04
## ASV1035      8.245477e-05  8.571965e-05  8.908362e-05  9.254703e-05
## ASV0070     -1.921419e-04 -1.999967e-04 -2.081103e-04 -2.164855e-04
## ASV0255      7.772494e-05  8.109490e-05  8.459335e-05  8.822339e-05
## ASV0057     -8.452872e-04 -8.818317e-04 -9.197889e-04 -9.591987e-04
## ASV0077     -1.203060e-04 -1.249729e-04 -1.297687e-04 -1.346917e-04
## ASV0625      8.472606e-04  8.844965e-04  9.232278e-04  9.635022e-04
## ASV2464      4.072125e-04  4.247715e-04  4.430071e-04  4.619386e-04
## ASV1315      7.390833e-04  7.731485e-04  8.087425e-04  8.459309e-04
## ASV2673      5.529315e-04  5.791589e-04  6.066247e-04  6.353868e-04
## ASV2161      2.298833e-04  2.409268e-04  2.525045e-04  2.646423e-04
## ASV0337     -3.600471e-04 -3.763824e-04 -3.934225e-04 -4.111945e-04
## ASV7680     -4.256775e-04 -4.453171e-04 -4.658326e-04 -4.872600e-04
## ASV0611      9.278306e-04  9.710914e-04  1.016326e-03  1.063620e-03
## ASV3118     -3.164441e-04 -3.312141e-04 -3.466576e-04 -3.628040e-04
## ASV1284      3.480995e-04  3.647703e-04  3.822232e-04  4.004919e-04
## ASV0889      2.483909e-04  2.595006e-04  2.710780e-04  2.831404e-04
## ASV4649     -2.644501e-04 -2.766109e-04 -2.893103e-04 -3.025704e-04
## ASV1108     -3.427602e-04 -3.591643e-04 -3.763544e-04 -3.943680e-04
## ASV0738     -3.423191e-05 -3.399901e-05 -3.359393e-05 -3.299550e-05
## ASV0473      4.816268e-05  5.021121e-05  5.233587e-05  5.453857e-05
## ASV0598     -3.694294e-04 -3.851646e-04 -4.014864e-04 -4.184093e-04
## ASV0429      6.084556e-04  6.359917e-04  6.647048e-04  6.946387e-04
## ASV1549      6.172186e-04  6.466229e-04  6.774259e-04  7.096937e-04
## ASV1203      4.529786e-04  4.732640e-04  4.943993e-04  5.164151e-04
## ASV4532      1.506500e-05  1.538304e-05  1.568449e-05  1.596637e-05
## ASV0274     -4.467719e-04 -4.658893e-04 -4.857339e-04 -5.063259e-04
## ASV0163     -6.440099e-04 -6.716742e-04 -7.003922e-04 -7.301925e-04
## ASV1298      2.607378e-04  2.718913e-04  2.834665e-04  2.954749e-04
## ASV9424     -5.667853e-04 -5.931684e-04 -6.207508e-04 -6.495846e-04
## ASV0412      8.580203e-04  8.966189e-04  9.368538e-04  9.787861e-04
## ASV0284      3.775938e-04  3.939144e-04  4.108671e-04  4.284699e-04
## ASV0620     -2.987198e-04 -3.132169e-04 -3.284241e-04 -3.443762e-04
## ASV0153     -6.074396e-04 -6.359771e-04 -6.658360e-04 -6.970754e-04
## ASV0498      7.803460e-05  8.288580e-05  8.805731e-05  9.357035e-05
## ASV0097      4.303807e-04  4.505260e-04  4.716025e-04  4.936525e-04
## ASV0104     -1.979220e-03 -2.069022e-03 -2.162705e-03 -2.260421e-03
## ASV1282      3.575581e-04  3.744117e-04  3.920376e-04  4.104682e-04
## ASV3883     -2.039560e-04 -2.136330e-04 -2.237641e-04 -2.343698e-04
## ASV0801      2.089779e-04  2.193308e-04  2.302068e-04  2.416326e-04
## ASV1611     -7.675126e-04 -8.029529e-04 -8.399783e-04 -8.786549e-04
## ASV0227     -2.818329e-04 -2.954575e-04 -3.097444e-04 -3.247256e-04
## ASV0833      3.059421e-04  3.208493e-04  3.364905e-04  3.529016e-04
## ASV0718      7.122643e-04  7.448491e-04  7.788651e-04  8.143702e-04
## ASV1139      2.527766e-04  2.632939e-04  2.741762e-04  2.854290e-04
## ASV0766     -1.948178e-04 -2.035513e-04 -2.126515e-04 -2.221316e-04
## ASV2091      9.310463e-04  9.714580e-04  1.013456e-03  1.057089e-03
## ASV1238     -3.169792e-05 -3.150946e-05 -3.118523e-05 -3.071099e-05
## ASV9193     -1.170265e-04 -1.239912e-04 -1.313828e-04 -1.392263e-04
## ASV0290     -7.804502e-05 -8.183329e-05 -8.580506e-05 -8.996884e-05
## ASV0231      7.520793e-04  7.860743e-04  8.215254e-04  8.584879e-04
## ASV0185      1.598733e-04  1.698763e-04  1.805574e-04  1.919645e-04
## ASV2330      2.163303e-04  2.259141e-04  2.358903e-04  2.462723e-04
## ASV3119     -2.588220e-04 -2.718012e-04 -2.854523e-04 -2.998114e-04
## ASV2368     -3.504551e-04 -3.670873e-04 -3.845051e-04 -4.027452e-04
## ASV0122     -2.659693e-04 -2.775038e-04 -2.894917e-04 -3.019469e-04
## ASV1044      4.862496e-04  5.098367e-04  5.345806e-04  5.605388e-04
## ASV0160     -6.514494e-04 -6.792344e-04 -7.080625e-04 -7.379607e-04
## ASV0326      4.349471e-04  4.549176e-04  4.757716e-04  4.975452e-04
## ASV1388      7.575441e-04  7.919199e-04  8.277787e-04  8.651777e-04
## ASV0792      8.559318e-04  8.942411e-04  9.341539e-04  9.757274e-04
## ASV0036     -5.484850e-04 -5.740890e-04 -6.008635e-04 -6.288599e-04
## ASV2125      8.842682e-04  9.243128e-04  9.660786e-04  1.009631e-03
## ASV1075      1.734767e-04  1.817998e-04  1.905256e-04  1.996738e-04
## ASV0390      1.752594e-04  1.842272e-04  1.936769e-04  2.036358e-04
## ASV3790     -7.121069e-04 -7.448088e-04 -7.789611e-04 -8.146238e-04
## ASV1535     -7.198364e-05 -7.604943e-05 -8.035801e-05 -8.492425e-05
## ASV0263      1.477218e-04  1.544944e-04  1.615643e-04  1.689432e-04
## ASV0675      1.192145e-03  1.248447e-03  1.307374e-03  1.369045e-03
## ASV3348      1.179575e-04  1.238828e-04  1.301184e-04  1.366816e-04
## ASV0058     -1.104512e-03 -1.153943e-03 -1.205450e-03 -1.259109e-03
## ASV4142      2.810007e-04  2.937050e-04  3.069514e-04  3.207602e-04
## ASV0059     -9.496468e-04 -9.919401e-04 -1.035991e-03 -1.081862e-03
## ASV0013     -2.010603e-03 -2.101882e-03 -2.197111e-03 -2.296446e-03
## ASV0033     -5.986333e-04 -6.266915e-04 -6.560428e-04 -6.867447e-04
## ASV4354     -2.581075e-04 -2.696417e-04 -2.816601e-04 -2.941807e-04
## ASV0022     -6.321771e-04 -6.617862e-04 -6.927577e-04 -7.251521e-04
## ASV0134     -1.611985e-04 -1.691930e-04 -1.775943e-04 -1.864235e-04
## ASV0415     -1.149141e-04 -1.188315e-04 -1.228073e-04 -1.268348e-04
## ASV10103    -4.364301e-04 -4.564496e-04 -4.773511e-04 -4.991700e-04
## ASV1613      7.026299e-04  7.340475e-04  7.667780e-04  8.008681e-04
## ASV0135     -3.070700e-05 -3.092227e-05 -3.103577e-05 -3.103306e-05
## ASV0469     -8.758857e-04 -9.149282e-04 -9.555936e-04 -9.979394e-04
## ASV0471      5.829685e-04  6.105376e-04  6.393835e-04  6.695616e-04
## ASV0451     -1.572332e-04 -1.650012e-04 -1.731640e-04 -1.817424e-04
## ASV0747      2.291629e-04  2.405266e-04  2.524625e-04  2.649993e-04
## ASV1314     -3.409128e-04 -3.573689e-04 -3.746263e-04 -3.927243e-04
## ASV0425     -9.825776e-04 -1.025432e-03 -1.069987e-03 -1.116296e-03
## ASV0559     -5.615759e-04 -5.861477e-04 -6.117030e-04 -6.382737e-04
## ASV0148     -6.007071e-04 -6.265131e-04 -6.533048e-04 -6.811090e-04
## ASV0129     -2.864717e-04 -2.977859e-04 -3.094437e-04 -3.214463e-04
## ASV1072      2.829108e-04  2.946535e-04  3.068134e-04  3.193999e-04
## ASV2390      2.132638e-04  2.226098e-04  2.323279e-04  2.424298e-04
## ASV0548      6.459142e-04  6.756360e-04  7.066828e-04  7.391101e-04
## ASV0168     -9.604671e-04 -1.003248e-03 -1.047808e-03 -1.094211e-03
## ASV0066     -7.237609e-04 -7.566680e-04 -7.910013e-04 -8.268166e-04
## ASV0468     -2.652973e-04 -2.773407e-04 -2.899036e-04 -3.030058e-04
## ASV0172     -1.356438e-04 -1.403183e-04 -1.450665e-04 -1.498806e-04
## ASV0236     -3.504554e-04 -3.642033e-04 -3.783575e-04 -3.929180e-04
## ASV0250      4.496467e-05  4.944532e-05  5.433283e-05  5.966112e-05
## ASV0338     -3.498541e-05 -3.507964e-05 -3.505039e-05 -3.488254e-05
## ASV0450     -5.401400e-06 -5.732783e-06 -6.086695e-06 -6.464793e-06
## ASV0377      7.931644e-04  8.293416e-04  8.670975e-04  9.064948e-04
## ASV1022      2.226236e-04  2.329388e-04  2.437198e-04  2.549868e-04
## ASV6174     -5.321048e-05 -5.550544e-05 -5.788982e-05 -6.036645e-05
## ASV0786      8.525026e-05  8.876137e-05  9.239174e-05  9.614312e-05
## ASV0053     -9.615086e-04 -1.005797e-03 -1.052056e-03 -1.100367e-03
## ASV0697     -2.713449e-04 -2.830395e-04 -2.951860e-04 -3.077976e-04
## ASV0785      7.036495e-04  7.355867e-04  7.689130e-04  8.036843e-04
## ASV1967     -4.617781e-04 -4.819353e-04 -5.028932e-04 -5.246772e-04
## ASV0385     -2.058077e-04 -2.142487e-04 -2.229834e-04 -2.320180e-04
## ASV0295      9.594633e-06  1.111147e-05  1.279373e-05  1.465701e-05
## ASV0072     -7.452796e-04 -7.778477e-04 -8.117154e-04 -8.469243e-04
## ASV0157     -3.071041e-04 -3.199965e-04 -3.333466e-04 -3.471627e-04
## ASV0501      3.629911e-04  3.806316e-04  3.991251e-04  4.185108e-04
## ASV10729    -5.868357e-04 -6.140808e-04 -6.425573e-04 -6.723179e-04
## ASV1470      2.445738e-04  2.542100e-04  2.641431e-04  2.743752e-04
## ASV0050     -1.888682e-03 -1.973603e-03 -2.062127e-03 -2.154388e-03
## ASV0411     -4.310393e-05 -4.453451e-05 -4.598597e-05 -4.745627e-05
## ASV0549      3.640768e-04  3.813602e-04  3.994669e-04  4.184366e-04
## ASV0184      2.238067e-04  2.340861e-04  2.448224e-04  2.560347e-04
## ASV0705      2.757698e-04  2.889360e-04  3.027279e-04  3.171746e-04
## ASV1715      6.760859e-04  7.070729e-04  7.394263e-04  7.732017e-04
## ASV0603      8.329975e-05  8.736697e-05  9.163746e-05  9.612185e-05
## ASV0826      2.175681e-04  2.268074e-04  2.363892e-04  2.463219e-04
## ASV0034     -8.511977e-04 -8.890072e-04 -9.283721e-04 -9.693451e-04
## ASV0838      1.876993e-04  1.964216e-04  2.055349e-04  2.150551e-04
## ASV0614     -4.876785e-04 -5.096135e-04 -5.324785e-04 -5.563081e-04
## ASV0014     -1.836211e-03 -1.919090e-03 -2.005515e-03 -2.095621e-03
## ASV0585     -1.057499e-04 -1.102082e-04 -1.148311e-04 -1.196225e-04
## ASV0016     -1.877718e-03 -1.962535e-03 -2.050985e-03 -2.143208e-03
## ASV5394     -4.816593e-04 -5.039023e-04 -5.271396e-04 -5.514126e-04
## ASV0666      4.039621e-04  4.221224e-04  4.410504e-04  4.607742e-04
## ASV2085      1.484657e-04  1.538779e-04  1.594055e-04  1.650425e-04
## ASV0003     -1.715199e-03 -1.792419e-03 -1.872925e-03 -1.956841e-03
## ASV0346     -1.879300e-05 -1.819523e-05 -1.744308e-05 -1.651946e-05
## ASV0267     -2.728606e-04 -2.847199e-04 -2.970387e-04 -3.098293e-04
## ASV0353      3.978770e-04  4.180883e-04  4.393550e-04  4.617329e-04
## ASV2419      4.813959e-04  5.028077e-04  5.251051e-04  5.483190e-04
## ASV0447      2.415491e-04  2.539495e-04  2.670133e-04  2.807771e-04
## ASV0654      7.600011e-04  7.952873e-04  8.321668e-04  8.707074e-04
## ASV0151      1.228429e-04  1.293070e-04  1.361349e-04  1.433487e-04
## ASV0065     -6.845564e-04 -7.151167e-04 -7.469545e-04 -7.801160e-04
## ASV0527      5.045002e-04  5.274514e-04  5.513992e-04  5.763827e-04
## ASV4055     -1.964115e-04 -2.060209e-04 -2.161107e-04 -2.267057e-04
## ASV0166     -5.495435e-04 -5.727304e-04 -5.967716e-04 -6.216885e-04
## ASV0417     -4.855658e-04 -5.072273e-04 -5.297904e-04 -5.532868e-04
## ASV0078     -3.783936e-04 -3.945983e-04 -4.114186e-04 -4.288712e-04
## ASV0322     -4.516824e-04 -4.706851e-04 -4.903856e-04 -5.108016e-04
## ASV0156     -5.942377e-04 -6.198201e-04 -6.463946e-04 -6.739912e-04
## ASV0648     -5.685621e-04 -5.951613e-04 -6.229815e-04 -6.520767e-04
## ASV0407      3.837668e-05  4.022086e-05  4.216141e-05  4.420444e-05
## ASV2030     -1.166617e-04 -1.215313e-04 -1.265771e-04 -1.318033e-04
## ASV0300      3.485857e-04  3.659600e-04  3.842168e-04  4.034009e-04
## ASV1150     -4.108720e-05 -4.264899e-05 -4.424987e-05 -4.588876e-05
## ASV0958      3.506779e-04  3.677093e-04  3.855804e-04  4.043333e-04
## ASV0216     -5.828128e-04 -6.083571e-04 -6.349253e-04 -6.625506e-04
## ASV0446      8.438570e-04  8.842377e-04  9.265440e-04  9.708658e-04
## ASV0367     -2.830035e-04 -2.959042e-04 -3.093684e-04 -3.234186e-04
## ASV0200     -5.176445e-04 -5.409919e-04 -5.653400e-04 -5.907276e-04
## ASV0334     -2.547557e-04 -2.645909e-04 -2.746960e-04 -2.850677e-04
## ASV1311      3.721632e-04  3.890378e-04  4.066399e-04  4.249974e-04
## ASV0458      3.959401e-04  4.136796e-04  4.321655e-04  4.514249e-04
## ASV1371      1.245741e-05  1.307556e-05  1.372496e-05  1.440720e-05
## ASV0418      4.639267e-04  4.840484e-04  5.049624e-04  5.266935e-04
## ASV0004      5.718214e-04  5.974558e-04  6.241687e-04  6.519991e-04
## ASV1943      4.168888e-04  4.352889e-04  4.544401e-04  4.743681e-04
## ASV1495     -1.201548e-04 -1.269052e-04 -1.340644e-04 -1.416588e-04
## ASV0901     -6.680128e-04 -6.993118e-04 -7.320539e-04 -7.663035e-04
## ASV0628      3.830335e-04  4.000264e-04  4.177155e-04  4.361242e-04
## ASV0400      1.595577e-04  1.668923e-04  1.745474e-04  1.825352e-04
## ASV0116     -5.053794e-04 -5.288967e-04 -5.534840e-04 -5.791878e-04
## ASV0788      4.187234e-04  4.378372e-04  4.577863e-04  4.786039e-04
## ASV0117      2.744614e-04  2.876819e-04  3.015451e-04  3.160824e-04
## ASV3137      7.645803e-05  8.002079e-05  8.374717e-05  8.764455e-05
## ASV0001      6.827954e-04  7.126504e-04  7.436984e-04  7.759781e-04
## ASV1651      4.467835e-04  4.659013e-04  4.857445e-04  5.063330e-04
## ASV1692      5.018433e-04  5.255823e-04  5.504341e-04  5.764497e-04
## ASV0660      2.782538e-04  2.900385e-04  3.022483e-04  3.148915e-04
## ASV0508      2.957890e-05  3.047775e-05  3.137779e-05  3.227606e-05
## ASV1660     -2.091981e-04 -2.193557e-04 -2.300101e-04 -2.411855e-04
## ASV0233      1.105009e-04  1.156496e-04  1.210352e-04  1.266687e-04
## ASV1343     -5.034890e-04 -5.268489e-04 -5.512644e-04 -5.767811e-04
## ASV0209      4.587356e-04  4.789241e-04  4.999293e-04  5.217783e-04
## ASV0193     -5.696172e-04 -5.938068e-04 -6.189047e-04 -6.449356e-04
## ASV0357     -3.475552e-05 -3.581555e-05 -3.687309e-05 -3.792357e-05
## ASV0198      1.369800e-04  1.436347e-04  1.506125e-04  1.579286e-04
## ASV0007      6.472422e-04  6.755436e-04  7.049766e-04  7.355777e-04
## ASV1772     -6.421473e-05 -6.692388e-05 -6.972930e-05 -7.263256e-05
## ASV0009      6.098774e-04  6.364706e-04  6.641204e-04  6.928604e-04
## ASV0006      2.421168e-04  2.520993e-04  2.624272e-04  2.731067e-04
## ASV0011     -7.033976e-04 -7.361128e-04 -7.703101e-04 -8.060528e-04
## ASV0015      4.803574e-04  5.018987e-04  5.243457e-04  5.477314e-04
## ASV0017      5.081520e-04  5.308849e-04  5.545695e-04  5.792398e-04
## ASV0235     -4.150721e-04 -4.345135e-04 -4.548439e-04 -4.761017e-04
## ASV0382      8.854711e-05  9.394715e-05  9.969709e-05  1.058198e-04
## ASV2357      6.232821e-04  6.520736e-04  6.821553e-04  7.135816e-04
## ASV0567     -4.419581e-04 -4.615945e-04 -4.820468e-04 -5.033446e-04
## ASV0165      5.007747e-04  5.239874e-04  5.482454e-04  5.735930e-04
## ASV0005      9.813290e-04  1.025228e-03  1.070968e-03  1.118618e-03
## ASV0384     -3.859508e-05 -3.951310e-05 -4.039157e-05 -4.122137e-05
## ASV0002      2.107687e-04  2.206402e-04  2.309646e-04  2.417618e-04
## ASV3017      5.715395e-04  5.968983e-04  6.233014e-04  6.507851e-04
## ASV0091      2.254358e-04  2.360705e-04  2.472012e-04  2.588506e-04
## ASV0186     -5.984666e-04 -6.260413e-04 -6.548432e-04 -6.849230e-04
## ASV0370      6.878237e-05  7.242545e-05  7.627445e-05  8.034187e-05
## ASV0018      1.023191e-03  1.069097e-03  1.116941e-03  1.166795e-03
## ASV1377      8.946454e-04  9.346610e-04  9.763485e-04  1.019768e-03
## ASV0019      1.024918e-03  1.070929e-03  1.118884e-03  1.168857e-03
## ASV0023      6.415282e-05  6.606779e-05  6.798014e-05  6.988280e-05
## ASV2194      3.235057e-04  3.380251e-04  3.531666e-04  3.689551e-04
## ASV1155     -3.525930e-05 -3.641049e-05 -3.756951e-05 -3.873278e-05
## ASV0510     -3.589637e-04 -3.736669e-04 -3.888723e-04 -4.045889e-04
## ASV2371     -3.586557e-04 -3.738174e-04 -3.895365e-04 -4.058263e-04
## ASV0024      1.437974e-05  1.401220e-05  1.354131e-05  1.295590e-05
## ASV2452      4.749370e-04  4.956273e-04  5.171356e-04  5.394870e-04
## ASV2332      2.182237e-05  2.346321e-05  2.524012e-05  2.716480e-05
## ASV2591      3.417208e-05  3.692880e-05  3.990918e-05  4.313055e-05
## ASV0521      6.768988e-04  7.089326e-04  7.424650e-04  7.775640e-04
## ASV5542      2.120381e-04  2.223341e-04  2.331316e-04  2.444546e-04
## ASV0336     -2.896328e-04 -3.019161e-04 -3.146628e-04 -3.278864e-04
## ASV10102     4.679247e-04  4.898748e-04  5.128367e-04  5.368550e-04
## ASV16823    -3.491177e-04 -3.638753e-04 -3.791766e-04 -3.950349e-04
## ASV3104      3.490720e-04  3.638257e-04  3.791227e-04  3.949765e-04
## ASV0781      1.787557e-04  1.870097e-04  1.956323e-04  2.046387e-04
## ASV10899     1.785407e-04  1.877660e-04  1.974893e-04  2.077384e-04
## ASV11222    -3.490441e-04 -3.637957e-04 -3.790905e-04 -3.949419e-04
## ASV11327    -3.489984e-04 -3.637461e-04 -3.790366e-04 -3.948835e-04
## ASV12458    -3.489527e-04 -3.636965e-04 -3.789828e-04 -3.948251e-04
## ASV1636     -2.857088e-04 -2.977622e-04 -3.102565e-04 -3.232023e-04
## ASV1890     -3.500995e-04 -3.651383e-04 -3.807546e-04 -3.969653e-04
## ASV2898      7.735465e-04  8.081668e-04  8.442367e-04  8.818081e-04
## ASV8328     -4.544324e-05 -4.608940e-05 -4.663803e-05 -4.707457e-05
## ASV0709     -6.343921e-04 -6.629586e-04 -6.927363e-04 -7.237697e-04
## ASV0856      1.074689e-04  1.128977e-04  1.186102e-04  1.246217e-04
## ASV0909     -2.539997e-04 -2.640152e-04 -2.743285e-04 -2.849395e-04
## ASV0937     -4.950709e-04 -5.176962e-04 -5.413161e-04 -5.659712e-04
## ASV11390    -3.488577e-04 -3.635936e-04 -3.788715e-04 -3.947047e-04
## ASV11966     1.920425e-04  2.015512e-04  2.115400e-04  2.220334e-04
## ASV12990     1.030611e-04  1.080302e-04  1.132370e-04  1.186923e-04
## ASV14797     3.728726e-04  3.894645e-04  4.067413e-04  4.247266e-04
## ASV14904    -3.488489e-04 -3.635844e-04 -3.788619e-04 -3.946947e-04
## ASV15304     1.069062e-04  1.126823e-04  1.187883e-04  1.252439e-04
## ASV16696    -3.488135e-04 -3.635461e-04 -3.788206e-04 -3.946502e-04
## ASV1690      1.961366e-04  2.059976e-04  2.163664e-04  2.272692e-04
## ASV2029      9.933027e-04  1.037985e-03  1.084559e-03  1.133096e-03
## ASV2834      5.359826e-04  5.605042e-04  5.861032e-04  6.128232e-04
## ASV4003      1.663781e-04  1.752386e-04  1.845982e-04  1.944863e-04
## ASV4064      3.713570e-04  3.883845e-04  4.061612e-04  4.247173e-04
## ASV4294      1.429186e-04  1.505741e-04  1.586662e-04  1.672213e-04
## ASV4609     -1.252673e-05 -1.281872e-05 -1.309973e-05 -1.336743e-05
## ASV6283     -3.488158e-04 -3.635495e-04 -3.788253e-04 -3.946565e-04
## ASV6491     -3.487701e-04 -3.634999e-04 -3.787715e-04 -3.945982e-04
## ASV7453      1.532886e-04  1.612817e-04  1.697101e-04  1.785985e-04
## ASV7959      3.857852e-05  4.133139e-05  4.429001e-05  4.746955e-05
## ASV8219      3.487425e-04  3.634704e-04  3.787400e-04  3.945646e-04
## ASV8547     -3.486968e-04 -3.634209e-04 -3.786862e-04 -3.945063e-04
## ASV9319      2.514640e-04  2.634765e-04  2.760601e-04  2.892412e-04
## ASV9382     -3.486713e-04 -3.633933e-04 -3.786566e-04 -3.944744e-04
## ASV11516    -3.486257e-04 -3.633438e-04 -3.786029e-04 -3.944162e-04
## ASV14377    -3.485800e-04 -3.632943e-04 -3.785492e-04 -3.943579e-04
## ASV1867      5.347926e-04  5.596930e-04  5.857258e-04  6.129400e-04
## ASV1895     -1.174325e-04 -1.222879e-04 -1.273139e-04 -1.325144e-04
## ASV3168      2.263500e-04  2.365276e-04  2.471318e-04  2.581774e-04
## ASV4449      4.391259e-04  4.581658e-04  4.779529e-04  4.985103e-04
## ASV6596      2.709736e-04  2.844895e-04  2.987003e-04  3.136430e-04
## ASV7492     -1.216137e-04 -1.259008e-04 -1.302663e-04 -1.347046e-04
## ASV9854     -1.753998e-04 -1.825029e-04 -1.898403e-04 -1.974153e-04
## ASV6296      3.484899e-04  3.631970e-04  3.784443e-04  3.942449e-04
## ASV4201      1.335766e-04  1.411241e-04  1.491286e-04  1.576192e-04
## ASV0552      9.009829e-04  9.432136e-04  9.873859e-04  1.033585e-03
## ASV3671     -6.257213e-05 -6.440888e-05 -6.623901e-05 -6.805534e-05
## ASV3529     -6.645575e-05 -6.826955e-05 -7.005878e-05 -7.181416e-05
## ASV1060      2.227880e-04  2.330947e-04  2.438652e-04  2.551190e-04
## ASV0239     -4.918672e-04 -5.129571e-04 -5.348435e-04 -5.575469e-04
## ASV5711     -4.532435e-04 -4.729014e-04 -4.933312e-04 -5.145567e-04
## ASV4152     -6.016107e-04 -6.281932e-04 -6.558617e-04 -6.846534e-04
## ASV1461      5.393397e-04  5.629086e-04  5.874118e-04  6.128778e-04
## ASV2877      4.407735e-04  4.604477e-04  4.809392e-04  5.022763e-04
## ASV0012      3.354399e-04  3.511432e-04  3.675662e-04  3.847401e-04
## ASV9823      9.444094e-05  9.750172e-05  1.006022e-04  1.037379e-04
## ASV0008      3.651328e-04  3.820784e-04  3.997883e-04  4.182949e-04
## ASV7832     -3.716690e-04 -3.880511e-04 -4.051010e-04 -4.228415e-04
## ASV1915      3.696373e-05  3.924475e-05  4.167507e-05  4.426443e-05
## ASV0055      2.551361e-04  2.664910e-04  2.783132e-04  2.906183e-04
## ASV0032      6.265279e-04  6.545530e-04  6.837530e-04  7.141708e-04
## ASV2977     -5.040814e-04 -5.262166e-04 -5.492429e-04 -5.731892e-04
## ASV0466      5.077204e-04  5.295880e-04  5.522957e-04  5.758670e-04
## ASV3866      5.550746e-04  5.807617e-04  6.076017e-04  6.356431e-04
## ASV0040      7.345906e-04  7.686272e-04  8.041946e-04  8.413574e-04
## ASV0496     -5.236596e-05 -5.592259e-05 -5.974011e-05 -6.383822e-05
## ASV0052      8.920013e-04  9.323533e-04  9.744356e-04  1.018314e-03
## ASV3828     -5.432080e-04 -5.673424e-04 -5.924783e-04 -6.186517e-04
## ASV1930      3.484567e-04  3.646142e-04  3.814962e-04  3.991326e-04
## ASV2126      5.555894e-04  5.807193e-04  6.069250e-04  6.342473e-04
## ASV0793      3.395242e-04  3.558017e-04  3.728583e-04  3.907306e-04
## ASV0299     -2.291760e-04 -2.387877e-04 -2.487437e-04 -2.590515e-04
## ASV0208      5.366410e-04  5.623499e-04  5.892881e-04  6.175138e-04
## ASV0511     -2.752956e-04 -2.867256e-04 -2.985529e-04 -3.107844e-04
## ASV1123     -3.626681e-04 -3.781202e-04 -3.941505e-04 -4.107741e-04
## ASV0099     -1.930991e-04 -2.012343e-04 -2.096652e-04 -2.183981e-04
## ASV0752     -5.067617e-05 -5.365984e-05 -5.683184e-05 -6.020445e-05
## ASV0883      8.442163e-06  9.136387e-06  9.887600e-06  1.070026e-05
## ASV0683      4.733097e-04  4.957246e-04  5.191912e-04  5.437575e-04
## ASV4117     -5.437727e-04 -5.678104e-04 -5.928322e-04 -6.188720e-04
## ASV2172      2.075832e-04  2.171353e-04  2.271110e-04  2.375277e-04
## ASV0330     -3.678363e-04 -3.844339e-04 -4.017450e-04 -4.197975e-04
## ASV0728      3.581973e-04  3.749967e-04  3.925671e-04  4.109419e-04
## ASV0499      7.147131e-04  7.486088e-04  7.841044e-04  8.212743e-04
## ASV0120     -7.784763e-04 -8.138934e-04 -8.508438e-04 -8.893866e-04
## ASV1446      5.567941e-05  5.735037e-05  5.901682e-05  6.067186e-05
## ASV17171    -5.182777e-04 -5.413380e-04 -5.653561e-04 -5.903665e-04
## ASV0533      1.543560e-04  1.618648e-04  1.697441e-04  1.780126e-04
## ASV2495     -2.154736e-04 -2.255937e-04 -2.361869e-04 -2.472756e-04
## ASV5582      1.780393e-04  1.854118e-04  1.930392e-04  2.009258e-04
## ASV1488      2.004858e-04  2.110184e-04  2.221134e-04  2.337994e-04
## ASV0682      5.019224e-04  5.259137e-04  5.510537e-04  5.773975e-04
## ASV0068     -3.053247e-05 -3.240602e-05 -3.440133e-05 -3.652630e-05
## ASV1987     -2.770328e-04 -2.908242e-04 -3.053209e-04 -3.205598e-04
## ASV0035      8.635979e-05  8.927058e-05  9.221290e-05  9.517919e-05
## ASV7192     -3.438807e-04 -3.586180e-04 -3.739149e-04 -3.897867e-04
## ASV0873      4.603270e-05  4.745569e-05  4.888372e-05  5.031253e-05
## ASV4749      2.105695e-05  2.088676e-05  2.060550e-05  2.019938e-05
## ASV2174      3.053776e-04  3.175458e-04  3.301089e-04  3.430732e-04
## ASV1476     -2.872497e-04 -3.001783e-04 -3.136597e-04 -3.277155e-04
## ASV0740     -7.192495e-04 -7.530234e-04 -7.883578e-04 -8.253220e-04
## ASV0170      1.494301e-04  1.561778e-04  1.632155e-04  1.705546e-04
## ASV2466     -6.425137e-04 -6.715917e-04 -7.019229e-04 -7.335561e-04
## ASV1709      4.933301e-04  5.152328e-04  5.380391e-04  5.617808e-04
## ASV6170     -3.988080e-04 -4.147948e-04 -4.313204e-04 -4.483968e-04
## ASV3673      4.896600e-04  5.107679e-04  5.327106e-04  5.555166e-04
## ASV1745      1.755929e-05  1.754181e-05  1.746643e-05  1.732769e-05
## ASV0380     -3.075220e-04 -3.191230e-04 -3.310514e-04 -3.433093e-04
## ASV0426     -9.828769e-05 -1.020428e-04 -1.059045e-04 -1.098728e-04
## ASV0202     -9.261199e-05 -9.505923e-05 -9.745344e-05 -9.977855e-05
## ASV6350     -3.970399e-04 -4.129794e-04 -4.294592e-04 -4.464916e-04
## ASV0713     -3.115034e-04 -3.258114e-04 -3.407547e-04 -3.563597e-04
## ASV1822      7.401227e-05  7.811043e-05  8.244251e-05  8.702157e-05
## ASV4569      4.846616e-04  5.060231e-04  5.282642e-04  5.514170e-04
## ASV0030     -1.190355e-04 -1.250789e-04 -1.314317e-04 -1.381090e-04
## ASV0331      2.113927e-04  2.219213e-04  2.329881e-04  2.446215e-04
## ASV2981      5.136342e-04  5.380071e-04  5.635180e-04  5.902173e-04
## ASV0828     -3.452398e-04 -3.619414e-04 -3.794518e-04 -3.978096e-04
## ASV2440      8.013749e-04  8.390160e-04  8.783929e-04  9.195821e-04
## ASV3006     -3.131864e-04 -3.251009e-04 -3.373627e-04 -3.499749e-04
## ASV3875     -3.131503e-04 -3.250621e-04 -3.373209e-04 -3.499301e-04
## ASV4511      2.016036e-04  2.113051e-04  2.214760e-04  2.321389e-04
## ASV4700     -3.131145e-04 -3.250236e-04 -3.372795e-04 -3.498857e-04
## ASV5804     -3.130784e-04 -3.249847e-04 -3.372378e-04 -3.498408e-04
## ASV6826      3.716956e-04  3.893855e-04  4.079127e-04  4.273164e-04
## ASV7280      3.282403e-04  3.445028e-04  3.615731e-04  3.794897e-04
## ASV7535     -3.130657e-04 -3.249715e-04 -3.372242e-04 -3.498268e-04
## ASV0651     -3.487426e-04 -3.638240e-04 -3.794854e-04 -3.957425e-04
## ASV0913      4.825253e-04  5.052002e-04  5.289265e-04  5.537516e-04
## ASV10832    -3.130316e-04 -3.249349e-04 -3.371849e-04 -3.497847e-04
## ASV1117     -6.713006e-04 -7.010076e-04 -7.319440e-04 -7.641542e-04
## ASV11329     1.894276e-04  2.000594e-04  2.113170e-04  2.232375e-04
## ASV13209     4.717978e-06  6.815016e-06  9.139655e-06  1.170904e-05
## ASV1345      1.035270e-04  1.091795e-04  1.151420e-04  1.214299e-04
## ASV1719     -3.129819e-04 -3.248820e-04 -3.371286e-04 -3.497249e-04
## ASV1886      3.805250e-04  3.971772e-04  4.145100e-04  4.325486e-04
## ASV2158     -6.342350e-05 -6.432859e-05 -6.513044e-05 -6.581655e-05
## ASV2189      4.172621e-04  4.361869e-04  4.559333e-04  4.765342e-04
## ASV2257      3.059030e-04  3.194307e-04  3.335252e-04  3.482089e-04
## ASV2283      3.129012e-04  3.247951e-04  3.370349e-04  3.496241e-04
## ASV2328      3.128651e-04  3.247563e-04  3.369933e-04  3.495793e-04
## ASV2434     -4.897722e-04 -5.107008e-04 -5.324475e-04 -5.550401e-04
## ASV2648      3.127818e-04  3.246662e-04  3.368959e-04  3.494742e-04
## ASV2698      4.933492e-04  5.160815e-04  5.398332e-04  5.646479e-04
## ASV2775      5.721714e-04  5.963173e-04  6.213608e-04  6.473261e-04
## ASV3171      3.127017e-04  3.245796e-04  3.368024e-04  3.493732e-04
## ASV3227      4.226416e-04  4.402723e-04  4.585382e-04  4.774545e-04
## ASV3397      4.391348e-05  4.666025e-05  4.957549e-05  5.266803e-05
## ASV3444      4.692044e-04  4.888796e-04  5.092938e-04  5.304699e-04
## ASV3556      3.126041e-04  3.244743e-04  3.366887e-04  3.492507e-04
## ASV3606     -3.125681e-04 -3.244355e-04 -3.366471e-04 -3.492060e-04
## ASV4190      4.355048e-04  4.555085e-04  4.764065e-04  4.982372e-04
## ASV4197      4.861411e-04  5.066333e-04  5.278948e-04  5.499484e-04
## ASV4722      4.485520e-04  4.685934e-04  4.894815e-04  5.112485e-04
## ASV4765      1.255939e-04  1.319237e-04  1.385639e-04  1.455274e-04
## ASV4809      3.124731e-04  3.243329e-04  3.365362e-04  3.490862e-04
## ASV4846      3.268697e-04  3.421080e-04  3.580328e-04  3.746725e-04
## ASV4903     -6.376088e-05 -6.471438e-05 -6.556896e-05 -6.631237e-05
## ASV4944     -3.124424e-04 -3.243003e-04 -3.365017e-04 -3.490498e-04
## ASV5151     -1.546720e-04 -1.635938e-04 -1.730517e-04 -1.830778e-04
## ASV5413     -3.124208e-04 -3.242775e-04 -3.364777e-04 -3.490246e-04
## ASV5537     -3.123848e-04 -3.242388e-04 -3.364362e-04 -3.489800e-04
## ASV5688      3.123489e-04  3.242002e-04  3.363946e-04  3.489354e-04
## ASV5752      1.830894e-04  1.925348e-04  2.024688e-04  2.129148e-04
## ASV6122     -3.123261e-04 -3.241760e-04 -3.363690e-04 -3.489082e-04
## ASV6135      3.122901e-04  3.241373e-04  3.363275e-04  3.488637e-04
## ASV6188     -3.122542e-04 -3.240987e-04 -3.362860e-04 -3.488191e-04
## ASV6216      4.849634e-04  5.053721e-04  5.265462e-04  5.485082e-04
## ASV6242      3.121741e-04  3.240122e-04  3.361926e-04  3.487184e-04
## ASV6383      3.121382e-04  3.239736e-04  3.361511e-04  3.486738e-04
## ASV6781      3.121023e-04  3.239350e-04  3.361096e-04  3.486293e-04
## ASV6799     -3.120664e-04 -3.238964e-04 -3.360682e-04 -3.485848e-04
## ASV7374     -3.120305e-04 -3.238578e-04 -3.360267e-04 -3.485403e-04
## ASV7539     -3.119946e-04 -3.238192e-04 -3.359853e-04 -3.484958e-04
## ASV8591     -3.119587e-04 -3.237806e-04 -3.359438e-04 -3.484513e-04
## ASV8637      3.119229e-04  3.237421e-04  3.359024e-04  3.484068e-04
## ASV12796    -3.118870e-04 -3.237035e-04 -3.358610e-04 -3.483624e-04
## ASV1934      3.950484e-04  4.132643e-04  4.322943e-04  4.521724e-04
## ASV22549     4.568954e-05  4.965162e-05  5.392467e-05  5.852961e-05
## ASV29857    -3.118568e-04 -3.236714e-04 -3.358269e-04 -3.483262e-04
## ASV3215      4.857927e-04  5.087118e-04  5.327042e-04  5.578195e-04
## ASV3236     -3.118180e-04 -3.236296e-04 -3.357820e-04 -3.482780e-04
## ASV3954     -3.117822e-04 -3.235911e-04 -3.357406e-04 -3.482335e-04
## ASV4850      3.117463e-04  3.235526e-04  3.356992e-04  3.481891e-04
## ASV5225      3.117105e-04  3.235141e-04  3.356578e-04  3.481447e-04
## ASV5532     -3.116747e-04 -3.234756e-04 -3.356165e-04 -3.481003e-04
## ASV7258      6.708288e-05  7.247575e-05  7.828644e-05  8.454455e-05
## ASV9474     -1.631876e-04 -1.682297e-04 -1.733158e-04 -1.784366e-04
## ASV11857    -3.116351e-04 -3.234338e-04 -3.355726e-04 -3.480542e-04
## ASV1202     -3.115993e-04 -3.233953e-04 -3.355312e-04 -3.480098e-04
## ASV14742     2.587181e-04  2.720558e-04  2.861014e-04  3.008926e-04
## ASV16652     1.364424e-04  1.434420e-04  1.507935e-04  1.585124e-04
## ASV2019      4.847029e-04  5.054832e-04  5.270730e-04  5.494982e-04
## ASV2410     -4.626349e-04 -4.835424e-04 -5.053591e-04 -5.281224e-04
## ASV2718      5.078763e-04  5.322371e-04  5.577553e-04  5.844837e-04
## ASV2738      5.425470e-04  5.652616e-04  5.888057e-04  6.132005e-04
## ASV2876      3.115206e-04  3.233108e-04  3.354405e-04  3.479126e-04
## ASV3177      3.114849e-04  3.232724e-04  3.353992e-04  3.478682e-04
## ASV4367      3.114491e-04  3.232339e-04  3.353579e-04  3.478239e-04
## ASV4635      1.410426e-04  1.494713e-04  1.584147e-04  1.679024e-04
## ASV4896      5.493227e-05  5.986871e-05  6.521180e-05  7.099147e-05
## ASV4907      2.745423e-04  2.890485e-04  3.043435e-04  3.204700e-04
## ASV5230     -3.114656e-04 -3.232534e-04 -3.353809e-04 -3.478508e-04
## ASV6509     -3.114298e-04 -3.232150e-04 -3.353396e-04 -3.478065e-04
## ASV7376     -3.113940e-04 -3.231765e-04 -3.352983e-04 -3.477621e-04
## ASV8163     -3.113583e-04 -3.231381e-04 -3.352570e-04 -3.477178e-04
## ASV8195     -3.113225e-04 -3.230997e-04 -3.352157e-04 -3.476735e-04
## ASV8923      2.238441e-04  2.352442e-04  2.472308e-04  2.598328e-04
## ASV9666     -2.718003e-04 -2.817207e-04 -2.918938e-04 -3.023184e-04
## ASV1482      3.224067e-04  3.377845e-04  3.538861e-04  3.707443e-04
## ASV2726      4.198188e-04  4.400123e-04  4.611683e-04  4.833308e-04
## ASV3281     -3.112930e-04 -3.230687e-04 -3.351834e-04 -3.476399e-04
## ASV4235     -3.112572e-04 -3.230303e-04 -3.351421e-04 -3.475956e-04
## ASV4808      4.903310e-04  5.112564e-04  5.329943e-04  5.555712e-04
## ASV4861     -4.886993e-04 -5.095464e-04 -5.312066e-04 -5.537073e-04
## ASV5276      4.841548e-04  5.047258e-04  5.260833e-04  5.482516e-04
## ASV5837      4.312045e-04  4.512831e-04  4.722822e-04  4.942434e-04
## ASV7098      4.391142e-04  4.594227e-04  4.806511e-04  5.028398e-04
## ASV8451     -3.110759e-04 -3.228338e-04 -3.349292e-04 -3.473650e-04
## ASV8694     -3.110402e-04 -3.227954e-04 -3.348880e-04 -3.473208e-04
## ASV0905     -1.875526e-04 -1.963566e-04 -2.055460e-04 -2.151338e-04
## ASV2900      3.900373e-04  4.055632e-04  4.216048e-04  4.381729e-04
## ASV3963     -3.013774e-04 -3.126767e-04 -3.242922e-04 -3.362257e-04
## ASV0041     -3.871994e-04 -4.058656e-04 -4.254269e-04 -4.459245e-04
## ASV1865      3.991786e-04  4.192670e-04  4.403814e-04  4.625734e-04
## ASV1140      3.211862e-04  3.366928e-04  3.529304e-04  3.699304e-04
## ASV1179      4.523978e-04  4.736098e-04  4.957941e-04  5.189927e-04
## ASV0279      6.199021e-04  6.474755e-04  6.762065e-04  7.061390e-04
## ASV0043     -6.640634e-05 -7.066329e-05 -7.521982e-05 -8.009828e-05
## ASV2097     -3.359623e-04 -3.500999e-04 -3.647752e-04 -3.800057e-04
## ASV0309     -1.686470e-04 -1.756354e-04 -1.828719e-04 -1.903623e-04
## ASV0607      7.712579e-04  8.073030e-04  8.449966e-04  8.844104e-04
## ASV0025     -8.192164e-04 -8.577797e-04 -8.981223e-04 -9.403218e-04
## ASV2284     -1.119879e-04 -1.154669e-04 -1.189736e-04 -1.225009e-04
## ASV0556      1.495866e-04  1.575837e-04  1.660261e-04  1.749386e-04
## ASV5040      2.552937e-04  2.644510e-04  2.738269e-04  2.834189e-04
## ASV2924     -2.762883e-04 -2.864831e-04 -2.969492e-04 -3.076871e-04
## ASV1331      9.777459e-04  1.022157e-03  1.068501e-03  1.116856e-03
## ASV0506     -4.300291e-04 -4.479586e-04 -4.665318e-04 -4.857633e-04
## ASV1514      7.360699e-04  7.696761e-04  8.047467e-04  8.413390e-04
## ASV2144      6.155162e-04  6.433041e-04  6.722871e-04  7.025122e-04
## ASV2265      8.214381e-04  8.589230e-04  8.980469e-04  9.388752e-04
## ASV5156      1.620096e-04  1.679327e-04  1.740029e-04  1.802187e-04
## ASV5534      1.256047e-04  1.296356e-04  1.337111e-04  1.378240e-04
## ASV5747     -4.591808e-05 -4.984301e-05 -5.407963e-05 -5.864972e-05
## ASV6657      3.607150e-04  3.761851e-04  3.922558e-04  4.089461e-04
## ASV0658     -4.016473e-04 -4.183804e-04 -4.357152e-04 -4.536660e-04
## ASV0716      1.028795e-04  1.072512e-04  1.117862e-04  1.164887e-04
## ASV1657      1.621912e-04  1.679669e-04  1.738689e-04  1.798937e-04
## ASV1885     -2.704321e-05 -2.996757e-05 -3.314933e-05 -3.660743e-05
## ASV2333      8.924888e-04  9.321401e-04  9.734366e-04  1.016438e-03
## ASV3375      3.200903e-04  3.333279e-04  3.470400e-04  3.612388e-04
## ASV4317      3.509478e-04  3.670628e-04  3.839013e-04  4.014954e-04
## ASV9599     -4.606556e-05 -5.000234e-05 -5.425166e-05 -5.883536e-05
## ASV0175     -1.199522e-03 -1.252657e-03 -1.307968e-03 -1.365528e-03
## ASV1032      3.436706e-04  3.578066e-04  3.724388e-04  3.875784e-04
## ASV1235     -1.834828e-06 -3.119993e-06 -4.555478e-06 -6.153797e-06
## ASV1262      1.060226e-03  1.107690e-03  1.157149e-03  1.208678e-03
## ASV1320      2.770717e-04  2.912754e-04  3.062301e-04  3.219761e-04
## ASV13797     3.854544e-04  4.021712e-04  4.195555e-04  4.376302e-04
## ASV1491      2.204803e-04  2.321222e-04  2.443920e-04  2.573223e-04
## ASV15014    -4.611688e-05 -5.005680e-05 -5.430935e-05 -5.889636e-05
## ASV1510      3.370458e-04  3.536050e-04  3.709740e-04  3.891900e-04
## ASV1551     -1.294622e-04 -1.350769e-04 -1.409124e-04 -1.469759e-04
## ASV1919     -1.868944e-06 -1.284017e-07  1.828317e-06  4.019239e-06
## ASV2114      1.831651e-04  1.904714e-04  1.980245e-04  2.058308e-04
## ASV21486    -4.608009e-05 -5.001528e-05 -5.426253e-05 -5.884360e-05
## ASV2448      5.342143e-04  5.573652e-04  5.814308e-04  6.064405e-04
## ASV2589      2.487129e-04  2.589749e-04  2.696032e-04  2.806070e-04
## ASV2608      4.282762e-04  4.471253e-04  4.667474e-04  4.871704e-04
## ASV2786      3.450543e-04  3.605013e-04  3.766105e-04  3.934089e-04
## ASV2827      4.515036e-04  4.715219e-04  4.923689e-04  5.140745e-04
## ASV2872      3.564769e-04  3.711748e-04  3.863867e-04  4.021233e-04
## ASV3125      4.265285e-04  4.445210e-04  4.631846e-04  4.825384e-04
## ASV3247      4.664481e-04  4.862967e-04  5.068970e-04  5.282702e-04
## ASV3451     -4.630726e-05 -5.026194e-05 -5.453025e-05 -5.913408e-05
## ASV3465     -7.386300e-05 -7.898998e-05 -8.447844e-05 -9.035238e-05
## ASV3809      2.641178e-04  2.748330e-04  2.859104e-04  2.973567e-04
## ASV4006      5.810594e-04  6.057075e-04  6.312775e-04  6.577941e-04
## ASV4046      4.106028e-04  4.278749e-04  4.457869e-04  4.643566e-04
## ASV4938     -4.910441e-05 -5.319147e-05 -5.759825e-05 -6.234689e-05
## ASV5435     -4.636264e-05 -5.032053e-05 -5.459212e-05 -5.919925e-05
## ASV5605      1.590932e-04  1.647557e-04  1.705416e-04  1.764472e-04
## ASV5635     -4.636597e-05 -5.032339e-05 -5.459437e-05 -5.920075e-05
## ASV5743      5.259318e-04  5.487716e-04  5.725218e-04  5.972129e-04
## ASV6627     -4.640140e-05 -5.036149e-05 -5.463530e-05 -5.924468e-05
## ASV6785     -4.638956e-05 -5.034810e-05 -5.462017e-05 -5.922759e-05
## ASV7368      5.837984e-04  6.103668e-04  6.380999e-04  6.670456e-04
## ASV9118      1.504956e-04  1.559742e-04  1.615892e-04  1.673395e-04
## ASV9135      1.119443e-04  1.153807e-04  1.188394e-04  1.223127e-04
## ASV9435      2.642853e-04  2.744272e-04  2.848564e-04  2.955729e-04
## ASV9671     -4.645224e-05 -5.041523e-05 -5.469200e-05 -5.930437e-05
## ASV0387     -5.772420e-04 -6.016642e-04 -6.269949e-04 -6.532580e-04
## ASV0454     -5.780914e-04 -6.029628e-04 -6.287932e-04 -6.556105e-04
## ASV0751     -3.728747e-04 -3.883778e-04 -4.044343e-04 -4.210566e-04
## ASV1081      1.599248e-04  1.672497e-04  1.748915e-04  1.828619e-04
## ASV1332      3.190287e-04  3.330662e-04  3.476690e-04  3.628555e-04
## ASV2659      5.177929e-04  5.415586e-04  5.663611e-04  5.922396e-04
## ASV2979      5.198883e-04  5.416818e-04  5.642668e-04  5.876625e-04
## ASV4184      1.992209e-04  2.062227e-04  2.133636e-04  2.206369e-04
## ASV6198      1.812363e-04  1.887428e-04  1.965242e-04  2.045886e-04
## ASV7454      3.380932e-04  3.522751e-04  3.669730e-04  3.821995e-04
## ASV8198      1.226779e-04  1.263299e-04  1.299888e-04  1.336442e-04
## ASV0855      7.773819e-04  8.127587e-04  8.496760e-04  8.881948e-04
## ASV10092     3.205237e-04  3.340878e-04  3.481663e-04  3.627750e-04
## ASV1532      4.382661e-04  4.593484e-04  4.814491e-04  5.046174e-04
## ASV2553      1.031209e-03  1.078044e-03  1.126911e-03  1.177891e-03
## ASV2741      4.278313e-04  4.484925e-04  4.701453e-04  4.928352e-04
## ASV4095      2.424547e-04  2.550321e-04  2.682725e-04  2.822092e-04
## ASV5295      2.858157e-04  2.969224e-04  3.083598e-04  3.201299e-04
## ASV5787     -4.659404e-05 -5.056692e-05 -5.485409e-05 -5.947736e-05
## ASV9455      3.914506e-04  4.081824e-04  4.255616e-04  4.436088e-04
## ASV10879     4.116838e-04  4.299319e-04  4.489439e-04  4.687490e-04
## ASV3997      2.990234e-04  3.135523e-04  3.287777e-04  3.447307e-04
## ASV6760      6.409778e-05  6.499535e-05  6.577504e-05  6.642140e-05
## ASV6990      2.904219e-04  3.024273e-04  3.148642e-04  3.277440e-04
## ASV9560      1.763312e-04  1.831440e-04  1.901655e-04  1.973989e-04
## ASV0220      1.720803e-04  1.800304e-04  1.883351e-04  1.970090e-04
## ASV2518      4.095537e-04  4.284998e-04  4.482966e-04  4.689802e-04
## ASV3615      6.304464e-04  6.584907e-04  6.877058e-04  7.181349e-04
## ASV0075      1.440507e-04  1.502113e-04  1.566082e-04  1.632486e-04
## ASV8070      6.067044e-05  6.165446e-05  6.254477e-05  6.332846e-05
## ASV1658      2.941435e-04  3.066923e-04  3.197246e-04  3.332556e-04
## ASV0773      4.865098e-04  5.076931e-04  5.297244e-04  5.526324e-04
## ASV0799      1.840125e-05  1.933716e-05  2.032210e-05  2.135868e-05
## ASV1839     -9.599738e-05 -9.966150e-05 -1.034215e-04 -1.072754e-04
## ASV0265      4.916468e-04  5.160080e-04  5.415969e-04  5.684755e-04
## ASV3741      1.803213e-04  1.880221e-04  1.960122e-04  2.042991e-04
## ASV0847      6.573291e-04  6.869994e-04  7.179376e-04  7.501920e-04
## ASV1026      7.012769e-04  7.326358e-04  7.653076e-04  7.993395e-04
## ASV1222     -2.008671e-04 -2.082176e-04 -2.157544e-04 -2.234761e-04
## ASV0729      9.988211e-05  1.044904e-04  1.093043e-04  1.143325e-04
## ASV0143     -5.253816e-04 -5.477887e-04 -5.710464e-04 -5.951787e-04
## ASV1328      1.646987e-04  1.729601e-04  1.816463e-04  1.907795e-04
## ASV9078     -1.565467e-04 -1.657001e-04 -1.754099e-04 -1.857091e-04
## ASV0027     -7.826367e-04 -8.193973e-04 -8.578461e-04 -8.980562e-04
## ASV0546     -3.237069e-04 -3.372113e-04 -3.512031e-04 -3.656940e-04
## ASV1136      8.533447e-04  8.916487e-04  9.315844e-04  9.732150e-04
## ASV3081      4.052342e-04  4.236693e-04  4.429188e-04  4.630176e-04
## ASV0531      1.886082e-04  1.978708e-04  2.075891e-04  2.177848e-04
## ASV2525      2.323858e-04  2.424695e-04  2.529553e-04  2.638567e-04
## ASV1083     -7.469888e-05 -7.691076e-05 -7.912814e-05 -8.134524e-05
## ASV0424      1.464954e-04  1.529617e-04  1.596925e-04  1.666969e-04
## ASV0644      3.845174e-05  4.173219e-05  4.527243e-05  4.909055e-05
## ASV6007     -4.570745e-05 -4.961117e-05 -5.382468e-05 -5.836968e-05
## ASV0564      2.210317e-04  2.321277e-04  2.437863e-04  2.560353e-04
## ASV1938      2.113972e-04  2.195757e-04  2.279979e-04  2.366657e-04
## ASV6516     -5.216850e-04 -5.452322e-04 -5.697898e-04 -5.953970e-04
## ASV0503     -5.909837e-04 -6.155442e-04 -6.409775e-04 -6.673029e-04
## ASV6913     -6.087886e-04 -6.352880e-04 -6.628602e-04 -6.915441e-04
## ASV0164     -4.868440e-04 -5.098402e-04 -5.339118e-04 -5.591080e-04
## ASV1576      5.781171e-04  6.042338e-04  6.314842e-04  6.599146e-04
## ASV1725      3.001626e-04  3.153243e-04  3.312578e-04  3.480011e-04
## ASV4501      2.289605e-04  2.377096e-04  2.467034e-04  2.559412e-04
## ASV10678    -5.113375e-04 -5.342906e-04 -5.582160e-04 -5.831501e-04
## ASV0944      4.273493e-04  4.476057e-04  4.688146e-04  4.910199e-04
## ASV2292      6.521371e-04  6.808581e-04  7.107475e-04  7.418452e-04
## ASV1090      4.295101e-04  4.489424e-04  4.692151e-04  4.903615e-04
## ASV9117     -1.907552e-04 -1.977757e-04 -2.049778e-04 -2.123608e-04
## ASV0285     -2.794763e-04 -2.941969e-04 -3.097199e-04 -3.260893e-04
## ASV0463     -4.064372e-04 -4.235072e-04 -4.411984e-04 -4.595254e-04
## ASV3199      3.490741e-04  3.634459e-04  3.783222e-04  3.937140e-04
## ASV0150     -1.567575e-04 -1.647416e-04 -1.731398e-04 -1.819733e-04
## ASV6583     -1.951448e-04 -2.026205e-04 -2.103227e-04 -2.182547e-04
## ASV0392      3.396186e-04  3.548903e-04  3.708108e-04  3.874045e-04
## ASV14007    -4.087222e-04 -4.265419e-04 -4.450680e-04 -4.643227e-04
## ASV0177     -2.195615e-04 -2.284566e-04 -2.376448e-04 -2.471300e-04
## ASV6448     -1.995425e-04 -2.106463e-04 -2.223905e-04 -2.348115e-04
## ASV5399     -9.047133e-05 -9.640377e-05 -1.027338e-04 -1.094864e-04
## ASV0277     -8.673014e-05 -9.076990e-05 -9.498990e-05 -9.939713e-05
## ASV2599      1.422120e-04  1.472251e-04  1.523475e-04  1.575766e-04
## ASV13465    -1.088368e-04 -1.121872e-04 -1.155627e-04 -1.189565e-04
## ASV2412      2.170431e-04  2.270129e-04  2.374263e-04  2.483017e-04
## ASV0423      4.340971e-04  4.552353e-04  4.774155e-04  5.006894e-04
## ASV5187      2.413528e-04  2.503856e-04  2.596679e-04  2.692005e-04
## ASV0701     -1.019370e-03 -1.066752e-03 -1.116281e-03 -1.168050e-03
## ASV4248      2.595214e-04  2.728052e-04  2.867805e-04  3.014828e-04
## ASV0519      4.307176e-04  4.512953e-04  4.728445e-04  4.954090e-04
## ASV0764      7.743094e-05  8.172858e-05  8.627729e-05  9.109196e-05
## ASV5385     -5.308288e-04 -5.554810e-04 -5.812535e-04 -6.081952e-04
## ASV3021     -2.884731e-04 -2.999461e-04 -3.117962e-04 -3.240305e-04
## ASV4119     -1.547967e-04 -1.605374e-04 -1.664326e-04 -1.724829e-04
## ASV2534      7.619529e-05  7.914954e-05  8.219562e-05  8.533494e-05
## ASV1061      4.183652e-04  4.396479e-04  4.620503e-04  4.856330e-04
## ASV0670      5.679430e-04  5.944029e-04  6.220709e-04  6.509999e-04
## ASV1384      2.549998e-04  2.679236e-04  2.815086e-04  2.957875e-04
## ASV1981      5.341724e-04  5.594526e-04  5.859114e-04  6.136013e-04
## ASV9632     -1.448076e-04 -1.491658e-04 -1.535471e-04 -1.579418e-04
## ASV4564      1.318089e-04  1.381050e-04  1.446983e-04  1.516021e-04
## ASV5289     -1.239278e-04 -1.299470e-04 -1.362651e-04 -1.428977e-04
## ASV0516      1.069230e-03  1.118441e-03  1.169833e-03  1.223494e-03
## ASV1463     -3.807533e-04 -3.974786e-04 -4.148782e-04 -4.329743e-04
## ASV0969      1.747704e-04  1.821965e-04  1.898978e-04  1.978809e-04
## ASV1113     -4.970160e-04 -5.198451e-04 -5.436851e-04 -5.685776e-04
## ASV1234     -3.807750e-05 -4.183266e-05 -4.593363e-05 -5.041012e-05
## ASV3814      4.606988e-05  4.583998e-05  4.542555e-05  4.480784e-05
## ASV1000      5.027336e-04  5.250162e-04  5.482134e-04  5.723564e-04
## ASV0079     -5.006228e-05 -5.323441e-05 -5.662194e-05 -6.023990e-05
## ASV0145      1.600578e-04  1.663518e-04  1.728444e-04  1.795384e-04
## ASV0457     -6.364436e-04 -6.645647e-04 -6.938335e-04 -7.242889e-04
## ASV1485      2.121853e-04  2.223967e-04  2.331036e-04  2.443302e-04
## ASV0535     -1.280927e-04 -1.332087e-04 -1.384938e-04 -1.439515e-04
## ASV0259     -4.215550e-04 -4.407203e-04 -4.607114e-04 -4.815594e-04
## ASV0570      3.653614e-05  3.905249e-05  4.175018e-05  4.464213e-05
## ASV0906      5.356618e-04  5.593069e-04  5.839178e-04  6.095279e-04
## ASV1748     -3.357468e-04 -3.528322e-04 -3.708037e-04 -3.897065e-04
## ASV5520     -2.051101e-04 -2.163089e-04 -2.281391e-04 -2.406356e-04
## ASV2288     -6.345917e-04 -6.629190e-04 -6.924293e-04 -7.231649e-04
## ASV1887     -1.367164e-04 -1.445576e-04 -1.528532e-04 -1.616276e-04
## ASV0374     -1.879366e-04 -1.956218e-04 -2.035688e-04 -2.117825e-04
## ASV0823      5.976353e-04  6.234524e-04  6.502855e-04  6.781674e-04
## ASV0717      3.072107e-04  3.213586e-04  3.361344e-04  3.515640e-04
## ASV0431      2.165674e-04  2.262809e-04  2.364062e-04  2.469587e-04
## ASV1030      9.090109e-04  9.524256e-04  9.979009e-04  1.045532e-03
## ASV1082     -1.321716e-04 -1.382965e-04 -1.446951e-04 -1.513786e-04
## ASV2684      9.757180e-05  1.034343e-04  1.096538e-04  1.162504e-04
## ASV0051      7.872906e-04  8.236758e-04  8.616965e-04  9.014223e-04
## ASV0513      4.211094e-05  4.461830e-05  4.728878e-05  5.013369e-05
## ASV0581      1.016947e-03  1.064193e-03  1.113577e-03  1.165191e-03
## ASV7282      1.817751e-04  1.912643e-04  2.012715e-04  2.118259e-04
## ASV3009     -5.544547e-04 -5.799497e-04 -6.065746e-04 -6.343759e-04
## ASV2106     -2.704110e-04 -2.817582e-04 -2.935314e-04 -3.057437e-04
## ASV1012      1.854718e-04  1.948035e-04  2.046066e-04  2.149036e-04
## ASV0921     -8.827812e-06 -8.851515e-06 -8.839332e-06 -8.786185e-06
## ASV0010     -7.954483e-04 -8.328414e-04 -8.719558e-04 -9.128665e-04
## ASV1178      2.349861e-05  2.512847e-05  2.687136e-05  2.873441e-05
## ASV2848     -4.126467e-04 -4.307022e-04 -4.494972e-04 -4.690588e-04
## ASV0586      1.153793e-03  1.207588e-03  1.263836e-03  1.322644e-03
## ASV4225      7.811596e-05  8.398323e-05  9.027912e-05  9.703192e-05
## ASV2156     -4.826784e-04 -5.051971e-04 -5.287434e-04 -5.533620e-04
## ASV9778     -2.998811e-04 -3.134300e-04 -3.275610e-04 -3.422970e-04
## ASV0493     -6.505484e-04 -6.791296e-04 -7.088703e-04 -7.398100e-04
## ASV3770      9.666891e-05  9.968774e-05  1.027365e-04  1.058102e-04
## ASV0470      8.091118e-04  8.461014e-04  8.847161e-04  9.250218e-04
## ASV0262     -3.567611e-04 -3.749794e-04 -3.941497e-04 -4.143218e-04
## ASV0998      5.010468e-04  5.244216e-04  5.488652e-04  5.744245e-04
## ASV7708     -1.260557e-04 -1.311811e-04 -1.364752e-04 -1.419401e-04
## ASV0453     -1.291659e-05 -1.334547e-05 -1.378854e-05 -1.424713e-05
## ASV0044      1.014467e-03  1.060768e-03  1.109095e-03  1.159528e-03
## ASV5490      1.577988e-04  1.645933e-04  1.716457e-04  1.789624e-04
## ASV2638      5.939888e-05  6.298393e-05  6.679099e-05  7.083306e-05
## ASV0829     -8.086988e-05 -8.358207e-05 -8.634049e-05 -8.914249e-05
## ASV0601      1.894409e-04  1.986218e-04  2.082518e-04  2.183529e-04
## ASV0234      4.505765e-04  4.714249e-04  4.932116e-04  5.159764e-04
## ASV0133      5.819466e-04  6.085688e-04  6.363590e-04  6.653639e-04
## ASV0323      6.271656e-04  6.569512e-04  6.881471e-04  7.208199e-04
## ASV0854     -4.799349e-05 -4.991029e-05 -5.188708e-05 -5.392429e-05
## ASV0110      7.827367e-04  8.190308e-04  8.569632e-04  8.966040e-04
## ASV0816      4.138077e-05  4.311878e-05  4.492108e-05  4.678945e-05
## ASV1031     -1.118483e-04 -1.162650e-04 -1.208234e-04 -1.255260e-04
## ASV0144     -3.215404e-04 -3.362245e-04 -3.515535e-04 -3.675536e-04
## ASV0020     -1.521309e-04 -1.603017e-04 -1.689462e-04 -1.780941e-04
## ASV0962     -2.618461e-04 -2.737516e-04 -2.861704e-04 -2.991218e-04
## ASV0794      5.322995e-04  5.583650e-04  5.857125e-04  6.144034e-04
## ASV7117     -2.566456e-04 -2.680248e-04 -2.798744e-04 -2.922115e-04
## ASV1008     -1.954971e-04 -2.050606e-04 -2.150987e-04 -2.256352e-04
## ASV0096      8.421258e-04  8.811480e-04  9.219288e-04  9.645429e-04
## ASV0128     -5.164157e-04 -5.416502e-04 -5.681418e-04 -5.959546e-04
## ASV5232      4.020594e-04  4.215991e-04  4.420911e-04  4.635809e-04
## ASV0031      2.697871e-05  2.789766e-05  2.883054e-05  2.977586e-05
## ASV1744     -5.054918e-05 -5.278275e-05 -5.512062e-05 -5.756914e-05
## ASV0289      4.704401e-04  4.922268e-04  5.150013e-04  5.388068e-04
## ASV7413     -1.275284e-04 -1.353440e-04 -1.436596e-04 -1.525065e-04
## ASV0822     -5.561309e-04 -5.803191e-04 -6.054606e-04 -6.315847e-04
## ASV8111     -4.874174e-04 -5.086774e-04 -5.308008e-04 -5.538190e-04
## ASV0687      3.668156e-04  3.846202e-04  4.032876e-04  4.228583e-04
## ASV0112      1.233039e-04  1.282505e-04  1.333537e-04  1.386145e-04
## ASV0987      2.963134e-04  3.108552e-04  3.261268e-04  3.421660e-04
## ASV5332     -1.323753e-04 -1.369215e-04 -1.415672e-04 -1.463117e-04
## ASV1129     -3.709922e-04 -3.881716e-04 -4.061306e-04 -4.249035e-04
## ASV1274     -1.197561e-04 -1.252134e-04 -1.309089e-04 -1.368524e-04
## ASV0119      6.858348e-04  7.175625e-04  7.507156e-04  7.853545e-04
## ASV0890      1.708605e-04  1.788486e-04  1.871992e-04  1.959275e-04
## ASV0848      9.990945e-04  1.045591e-03  1.094199e-03  1.145010e-03
## ASV5944     -5.365181e-04 -5.608383e-04 -5.862097e-04 -6.126736e-04
## ASV19741    -5.104750e-04 -5.335332e-04 -5.575818e-04 -5.826593e-04
## ASV0504     -5.811463e-04 -6.066004e-04 -6.330798e-04 -6.606190e-04
## ASV2146     -3.704809e-04 -3.864796e-04 -4.031190e-04 -4.204224e-04
## ASV0089     -3.180527e-04 -3.328736e-04 -3.483674e-04 -3.645630e-04
## ASV2301     -3.483076e-04 -3.647143e-04 -3.818836e-04 -3.998499e-04
## ASV2982      1.476012e-04  1.565115e-04  1.659749e-04  1.760244e-04
## ASV0891     -4.308015e-04 -4.503743e-04 -4.707942e-04 -4.920941e-04
## ASV0093      7.055388e-04  7.378881e-04  7.716673e-04  8.069351e-04
## ASV0042      3.420058e-04  3.576975e-04  3.740832e-04  3.911916e-04
## ASV0980      4.618405e-04  4.822314e-04  5.034503e-04  5.255245e-04
## ASV0069     -1.157224e-04 -1.213102e-04 -1.271681e-04 -1.333090e-04
## ASV1364     -7.504279e-05 -7.815176e-05 -8.136787e-05 -8.469283e-05
## ASV0524     -1.382883e-04 -1.451284e-04 -1.523153e-04 -1.598670e-04
## ASV0435      9.452182e-04  9.893972e-04  1.035601e-03  1.083919e-03
## ASV0517     -3.873791e-04 -4.055230e-04 -4.245024e-04 -4.443547e-04
## ASV3167     -1.750910e-04 -1.838598e-04 -1.930762e-04 -2.027630e-04
## ASV4280     -5.478348e-05 -5.700518e-05 -5.930298e-05 -6.167865e-05
## ASV1158      2.436551e-04  2.559639e-04  2.688921e-04  2.824687e-04
## ASV2214      1.665122e-04  1.738186e-04  1.814306e-04  1.893606e-04
## ASV0544     -2.195076e-04 -2.301390e-04 -2.412896e-04 -2.529849e-04
## ASV5326     -3.869159e-05 -4.045355e-05 -4.229491e-05 -4.421943e-05
## ASV3765     -5.599163e-04 -5.856688e-04 -6.125624e-04 -6.406436e-04
## ASV4646     -2.437490e-05 -2.675003e-05 -2.932505e-05 -3.211429e-05
## ASV0090      5.502880e-05  5.711532e-05  5.925399e-05  6.144335e-05
## ASV3680      4.988660e-04  5.199980e-04  5.419138e-04  5.646330e-04
## ASV0111      8.556096e-05  8.909524e-05  9.275004e-05  9.652711e-05
## ASV0768      3.296962e-04  3.454594e-04  3.619788e-04  3.792907e-04
## ASV4862     -1.283685e-05 -1.300083e-05 -1.313179e-05 -1.322457e-05
## ASV1742     -4.065721e-04 -4.238768e-04 -4.418437e-04 -4.604932e-04
## ASV3701     -5.186536e-05 -5.346940e-05 -5.508712e-05 -5.671542e-05
## ASV2386     -2.568292e-04 -2.686070e-04 -2.809028e-04 -2.937372e-04
## ASV0375     -5.876464e-04 -6.136059e-04 -6.406366e-04 -6.687772e-04
## ASV2796      1.470010e-04  1.530436e-04  1.593036e-04  1.657875e-04
## ASV1369      4.036330e-04  4.214938e-04  4.401042e-04  4.594936e-04
## ASV10272    -3.708673e-04 -3.875638e-04 -4.049681e-04 -4.231063e-04
## ASV10354    -3.708154e-04 -3.875071e-04 -4.049062e-04 -4.230387e-04
## ASV1067     -2.790120e-05 -2.913192e-05 -3.041211e-05 -3.174332e-05
## ASV1900      7.861987e-04  8.229018e-04  8.612836e-04  9.014174e-04
## ASV4079     -1.362426e-04 -1.428131e-04 -1.496998e-04 -1.569174e-04
## ASV4149      5.122344e-04  5.341578e-04  5.569130e-04  5.805227e-04
## ASV5140     -3.707633e-04 -3.874502e-04 -4.048440e-04 -4.229706e-04
## ASV10782    -9.508969e-06 -9.329681e-06 -9.085264e-06 -8.767796e-06
## ASV4273     -8.189939e-05 -8.513498e-05 -8.846524e-05 -9.188963e-05
## ASV8121      3.598028e-04  3.765071e-04  3.939699e-04  4.122242e-04
## ASV8438     -3.707199e-04 -3.874030e-04 -4.047928e-04 -4.229152e-04
## ASV9390     -3.706680e-04 -3.873464e-04 -4.047310e-04 -4.228477e-04
## ASV1340      5.221342e-04  5.467134e-04  5.724331e-04  5.993444e-04
## ASV2650     -5.476657e-04 -5.718822e-04 -5.970867e-04 -6.233123e-04
## ASV4674      2.828084e-04  2.957648e-04  3.092904e-04  3.234079e-04
## ASV10492    -1.931004e-05 -2.006417e-05 -2.084096e-05 -2.164056e-05
## ASV11430    -3.705931e-04 -3.872648e-04 -4.046422e-04 -4.227511e-04
## ASV12135    -3.705412e-04 -3.872082e-04 -4.045804e-04 -4.226836e-04
## ASV14970    -3.704894e-04 -3.871516e-04 -4.045186e-04 -4.226162e-04
## ASV1954      4.275726e-04  4.473200e-04  4.679488e-04  4.894953e-04
## ASV2613      6.636499e-04  6.939450e-04  7.255640e-04  7.585594e-04
## ASV2757      2.577788e-04  2.688721e-04  2.803924e-04  2.923520e-04
## ASV2909     -3.980928e-04 -4.169018e-04 -4.365922e-04 -4.572045e-04
## ASV2954     -7.527289e-05 -7.848920e-05 -8.182584e-05 -8.528580e-05
## ASV2969      3.744710e-04  3.923984e-04  4.111854e-04  4.308731e-04
## ASV3410      7.933475e-05  8.339418e-05  8.767110e-05  9.217779e-05
## ASV3575      1.930626e-04  2.018889e-04  2.111045e-04  2.207255e-04
## ASV4275      4.200388e-04  4.384375e-04  4.575712e-04  4.774633e-04
## ASV4652      7.641040e-05  8.039542e-05  8.459901e-05  8.903373e-05
## ASV4761      4.199220e-04  4.383344e-04  4.574812e-04  4.773852e-04
## ASV6003      3.325468e-04  3.487169e-04  3.656854e-04  3.834923e-04
## ASV6110     -3.706035e-04 -3.872766e-04 -4.046555e-04 -4.227661e-04
## ASV7427      2.404546e-04  2.513490e-04  2.627116e-04  2.745605e-04
## ASV8092     -3.705699e-04 -3.872399e-04 -4.046155e-04 -4.227225e-04
## ASV8169     -3.705180e-04 -3.871833e-04 -4.045537e-04 -4.226550e-04
## ASV9693      1.632195e-04  1.707712e-04  1.786611e-04  1.869030e-04
## ASV10913     1.801905e-04  1.888368e-04  1.978988e-04  2.073965e-04
## ASV1979     -5.781267e-05 -6.021415e-05 -6.270078e-05 -6.527443e-05
## ASV3772      4.569935e-04  4.774145e-04  4.986912e-04  5.208549e-04
## ASV0113      9.106109e-05  9.507198e-05  9.924679e-05  1.035913e-04
## ASV1800     -3.598269e-05 -3.751455e-05 -3.909692e-05 -4.072958e-05
## ASV2335     -4.796148e-04 -5.006988e-04 -5.226517e-04 -5.455058e-04
## ASV0692      1.590580e-04  1.664448e-04  1.741636e-04  1.822282e-04
## ASV1120      2.059895e-04  2.155977e-04  2.256453e-04  2.361514e-04
## ASV1434     -1.086928e-03 -1.137359e-03 -1.190071e-03 -1.245162e-03
## ASV0076     -1.214683e-04 -1.273020e-04 -1.334151e-04 -1.398207e-04
## ASV0361      8.137783e-04  8.516438e-04  8.912304e-04  9.326127e-04
## ASV2231     -2.792627e-04 -2.934003e-04 -3.082809e-04 -3.239449e-04
## ASV2018     -1.221973e-05 -1.287270e-05 -1.356447e-05 -1.429775e-05
## ASV1529      6.854924e-04  7.180639e-04  7.521773e-04  7.879049e-04
## ASV0841     -3.063222e-05 -3.166098e-05 -3.270134e-05 -3.375082e-05
## ASV2556     -4.039528e-04 -4.222127e-04 -4.412541e-04 -4.611065e-04
## ASV2777      4.990116e-04  5.202111e-04  5.422001e-04  5.649987e-04
## ASV0355      4.185832e-04  4.379966e-04  4.582882e-04  4.794960e-04
## ASV5169     -5.821772e-04 -6.089295e-04 -6.368641e-04 -6.660288e-04
## ASV3091      2.838836e-04  2.974641e-04  3.116959e-04  3.266102e-04
## ASV2435      4.122240e-04  4.311016e-04  4.508086e-04  4.713783e-04
## ASV6822     -2.581786e-04 -2.696382e-04 -2.815682e-04 -2.939845e-04
## ASV12605    -6.331169e-04 -6.621709e-04 -6.925080e-04 -7.241806e-04
## ASV0286     -4.173625e-04 -4.363614e-04 -4.561972e-04 -4.769054e-04
## ASV0074     -2.292435e-05 -2.472259e-05 -2.666386e-05 -2.875913e-05
## ASV2485     -3.517854e-05 -3.733724e-05 -3.964853e-05 -4.212457e-05
## ASV1233     -8.074016e-04 -8.448276e-04 -8.839471e-04 -9.248333e-04
## ASV0356     -3.784765e-04 -3.953564e-04 -4.129469e-04 -4.312748e-04
## ASV2918     -4.850093e-04 -5.069466e-04 -5.298275e-04 -5.536889e-04
## ASV1427      4.584112e-08 -1.593160e-07 -3.934780e-07 -6.597705e-07
## ASV1409      4.727648e-04  4.952123e-04  5.187210e-04  5.433404e-04
## ASV0770      1.486364e-04  1.549655e-04  1.615289e-04  1.683320e-04
## ASV1403     -5.642451e-04 -5.899864e-04 -6.168517e-04 -6.448859e-04
## ASV0314     -3.068164e-04 -3.209276e-04 -3.356620e-04 -3.510444e-04
## ASV0187      1.450898e-06  8.647944e-07  2.002225e-07 -5.499010e-07
## ASV0313     -4.153699e-04 -4.342227e-04 -4.538895e-04 -4.744018e-04
## ASV1087      7.142682e-04  7.472709e-04  7.817532e-04  8.177776e-04
## ASV1970      4.161626e-05  4.348444e-05  4.543333e-05  4.746635e-05
## ASV0754      5.763713e-04  6.030725e-04  6.309771e-04  6.601366e-04
## ASV3775     -3.960097e-04 -4.147270e-04 -4.343210e-04 -4.548321e-04
## ASV0132      1.658074e-04  1.734021e-04  1.813311e-04  1.896076e-04
## ASV2329     -1.185981e-04 -1.251547e-04 -1.320841e-04 -1.394066e-04
## ASV0561      4.970041e-04  5.195672e-04  5.431040e-04  5.676520e-04
## ASV0130     -6.095406e-04 -6.379706e-04 -6.676953e-04 -6.987705e-04
## ASV0226      6.844494e-04  7.159871e-04  7.489289e-04  7.833330e-04
## ASV12648    -4.741868e-04 -4.953651e-04 -5.174447e-04 -5.404613e-04
## ASV0204      6.823325e-04  7.137628e-04  7.465916e-04  7.808766e-04
## ASV0767      1.181522e-04  1.230999e-04  1.282225e-04  1.335230e-04
## ASV0335     -3.728639e-04 -3.901218e-04 -4.081531e-04 -4.269899e-04
## ASV5901     -1.080358e-04 -1.124833e-04 -1.170914e-04 -1.218648e-04
## ASV0596     -1.461742e-04 -1.523289e-04 -1.587056e-04 -1.653089e-04
## ASV9271      1.553807e-04  1.639492e-04  1.730097e-04  1.825903e-04
## ASV0904      6.100474e-04  6.387766e-04  6.688420e-04  7.003042e-04
## ASV15270    -1.763433e-04 -1.856695e-04 -1.954967e-04 -2.058505e-04
## ASV0990     -1.711631e-04 -1.792581e-04 -1.877328e-04 -1.966047e-04
## ASV0155     -3.655237e-04 -3.823913e-04 -4.000134e-04 -4.184217e-04
## ASV0086     -5.391720e-06 -5.661455e-06 -5.944917e-06 -6.242797e-06
## ASV2581     -2.909318e-05 -3.027912e-05 -3.150072e-05 -3.275749e-05
## ASV1579     -4.288747e-04 -4.493277e-04 -4.707521e-04 -4.931936e-04
## ASV7730     -2.420025e-05 -2.618575e-05 -2.831738e-05 -3.060375e-05
## ASV0897      1.812518e-04  1.899674e-04  1.991038e-04  2.086815e-04
## ASV1975      8.271002e-04  8.653657e-04  9.053579e-04  9.471513e-04
##                                                                    
## (Intercept)  7.435691e-07  1.383026e-07 -6.477378e-07 -1.650024e-06
## ASV1236      4.438954e-04  4.631211e-04  4.830950e-04  5.038391e-04
## ASV0421     -8.000014e-04 -8.353445e-04 -8.721270e-04 -9.103972e-04
## ASV0691     -6.716417e-04 -6.995997e-04 -7.285494e-04 -7.585121e-04
## ASV0899      8.803737e-06  1.039830e-05  1.215839e-05  1.409748e-05
## ASV1004      9.016737e-04  9.411470e-04  9.821920e-04  1.024857e-03
## ASV1041     -6.161565e-04 -6.434116e-04 -6.717751e-04 -7.012835e-04
## ASV1058      8.408748e-04  8.778587e-04  9.163349e-04  9.563520e-04
## ASV12542     2.547795e-04  2.655635e-04  2.767472e-04  2.883408e-04
## ASV1294      9.846959e-04  1.028590e-03  1.074306e-03  1.121906e-03
## ASV13113     3.666373e-04  3.841879e-04  4.025828e-04  4.218629e-04
## ASV1318      8.543701e-04  8.920410e-04  9.312373e-04  9.720091e-04
## ASV2269     -2.560960e-04 -2.674491e-04 -2.792643e-04 -2.915565e-04
## ASV2542      5.632949e-04  5.895579e-04  6.170180e-04  6.457270e-04
## ASV2660     -4.901506e-04 -5.114452e-04 -5.335728e-04 -5.565580e-04
## ASV2737     -3.124854e-05 -3.304324e-05 -3.494372e-05 -3.695593e-05
## ASV2840      6.495378e-04  6.775212e-04  7.065784e-04  7.367388e-04
## ASV3053      3.383947e-05  3.520349e-05  3.661446e-05  3.807351e-05
## ASV3077      2.029739e-04  2.118211e-04  2.210204e-04  2.305832e-04
## ASV3134      7.333350e-04  7.680647e-04  8.044305e-04  8.425087e-04
## ASV3140      3.203052e-04  3.352033e-04  3.507711e-04  3.670362e-04
## ASV3579      1.338249e-04  1.407062e-04  1.479600e-04  1.556074e-04
## ASV6119     -2.560137e-04 -2.673595e-04 -2.791668e-04 -2.914505e-04
## ASV7557     -2.559710e-04 -2.673130e-04 -2.791161e-04 -2.913952e-04
## ASV8422      1.331430e-04  1.385386e-04  1.441161e-04  1.498789e-04
## ASV1086     -6.932262e-05 -7.224469e-05 -7.527610e-05 -7.841998e-05
## ASV1310      4.833662e-04  5.047630e-04  5.270329e-04  5.502051e-04
## ASV15750    -1.201445e-04 -1.253270e-04 -1.307049e-04 -1.362829e-04
## ASV16905    -2.559524e-04 -2.672926e-04 -2.790938e-04 -2.913708e-04
## ASV2033      4.873966e-04  5.100251e-04  5.336761e-04  5.583931e-04
## ASV2089      1.758840e-04  1.837194e-04  1.918761e-04  2.003646e-04
## ASV2127      6.920890e-04  7.224855e-04  7.541051e-04  7.869875e-04
## ASV2725      7.768436e-04  8.102396e-04  8.449145e-04  8.809039e-04
## ASV2804     -2.559419e-04 -2.672812e-04 -2.790815e-04 -2.913576e-04
## ASV3075      4.986856e-04  5.208575e-04  5.439516e-04  5.680014e-04
## ASV3327      4.785801e-04  5.008405e-04  5.241140e-04  5.484445e-04
## ASV3342      5.181795e-04  5.418836e-04  5.666249e-04  5.924446e-04
## ASV3532     -4.696758e-04 -4.912372e-04 -5.137499e-04 -5.372524e-04
## ASV3600      5.876938e-04  6.143102e-04  6.420738e-04  6.710293e-04
## ASV4013      4.902937e-04  5.120213e-04  5.346403e-04  5.581810e-04
## ASV4136      4.799782e-04  5.007179e-04  5.222616e-04  5.446330e-04
## ASV4195      2.558811e-04  2.672151e-04  2.790095e-04  2.912793e-04
## ASV4407     -2.558385e-04 -2.671686e-04 -2.789589e-04 -2.912241e-04
## ASV4717      5.688029e-06  5.414809e-06  5.089122e-06  4.706201e-06
## ASV6794      2.495313e-04  2.597296e-04  2.702769e-04  2.811800e-04
## ASV8324     -2.558217e-04 -2.671500e-04 -2.789382e-04 -2.912012e-04
## ASV8981     -6.596342e-05 -6.848211e-05 -7.106358e-05 -7.370593e-05
## ASV9859      2.074851e-04  2.178528e-04  2.287586e-04  2.402319e-04
## ASV0936     -4.026775e-04 -4.206911e-04 -4.394608e-04 -4.590143e-04
## ASV12683    -4.410428e-05 -4.630549e-05 -4.861509e-05 -5.103797e-05
## ASV1293      5.851248e-04  6.106387e-04  6.371603e-04  6.647203e-04
## ASV13055    -6.072802e-05 -6.321478e-05 -6.578067e-05 -6.842588e-05
## ASV17063    -2.557536e-04 -2.670763e-04 -2.788586e-04 -2.911152e-04
## ASV2228      2.557110e-04  2.670299e-04  2.788080e-04  2.910600e-04
## ASV2769     -4.619296e-05 -4.793517e-05 -4.971927e-05 -5.154387e-05
## ASV2803      1.129697e-04  1.174456e-04  1.220628e-04  1.268228e-04
## ASV2896      3.230917e-04  3.378188e-04  3.531952e-04  3.692484e-04
## ASV3062      1.038460e-04  1.091563e-04  1.147512e-04  1.206469e-04
## ASV3107      3.919699e-04  4.099125e-04  4.286460e-04  4.482024e-04
## ASV3265      7.629492e-04  7.963007e-04  8.309783e-04  8.670237e-04
## ASV3666     -1.785404e-05 -1.869597e-05 -1.957539e-05 -2.049377e-05
## ASV4497      1.821055e-04  1.901763e-04  1.985807e-04  2.073304e-04
## ASV6914     -9.243937e-05 -9.674024e-05 -1.012331e-04 -1.059255e-04
## ASV0576     -8.826480e-04 -9.199264e-04 -9.585766e-04 -9.986324e-04
## ASV0673      2.512502e-04  2.635703e-04  2.764979e-04  2.900623e-04
## ASV0772      2.729164e-04  2.850562e-04  2.977024e-04  3.108736e-04
## ASV0862     -2.171183e-04 -2.262464e-04 -2.357052e-04 -2.455020e-04
## ASV0898      2.355060e-04  2.468133e-04  2.586614e-04  2.710755e-04
## ASV0910      5.057253e-04  5.296438e-04  5.546813e-04  5.808889e-04
## ASV0964     -3.267550e-04 -3.409680e-04 -3.557407e-04 -3.710900e-04
## ASV10059     2.403524e-04  2.519965e-04  2.642144e-04  2.770349e-04
## ASV10263    -2.559420e-04 -2.672822e-04 -2.790834e-04 -2.913608e-04
## ASV1088      2.679755e-04  2.807042e-04  2.940396e-04  3.080112e-04
## ASV1101      4.448761e-04  4.647865e-04  4.855266e-04  5.071252e-04
## ASV1183      2.886498e-04  3.018556e-04  3.156379e-04  3.300191e-04
## ASV11956     9.978016e-05  1.035181e-04  1.073541e-04  1.112874e-04
## ASV12774    -4.217208e-05 -4.430793e-05 -4.655292e-05 -4.891247e-05
## ASV1321      1.222764e-04  1.286826e-04  1.354417e-04  1.425741e-04
## ASV13793    -2.558897e-04 -2.672250e-04 -2.790209e-04 -2.912925e-04
## ASV14482    -2.853514e-05 -3.013555e-05 -3.182679e-05 -3.361364e-05
## ASV15483     1.825511e-04  1.909927e-04  1.998164e-04  2.090387e-04
## ASV2062      1.131984e-03  1.182776e-03  1.235709e-03  1.290858e-03
## ASV2132      5.239950e-04  5.482970e-04  5.736984e-04  6.002463e-04
## ASV2413      7.227004e-04  7.544122e-04  7.874006e-04  8.217076e-04
## ASV2490      4.662160e-04  4.859921e-04  5.065010e-04  5.277607e-04
## ASV2594      2.625422e-04  2.743259e-04  2.866152e-04  2.994304e-04
## ASV2822     -2.559609e-04 -2.673029e-04 -2.791062e-04 -2.913859e-04
## ASV2863      4.395554e-04  4.586339e-04  4.784586e-04  4.990519e-04
## ASV2910      5.715224e-04  5.962510e-04  6.219424e-04  6.486254e-04
## ASV2980      2.099657e-04  2.191573e-04  2.287115e-04  2.386390e-04
## ASV3307      2.558897e-04  2.672253e-04  2.790216e-04  2.912937e-04
## ASV3474      4.108150e-04  4.302425e-04  4.505803e-04  4.718701e-04
## ASV3502      8.384840e-04  8.763227e-04  9.157775e-04  9.569096e-04
## ASV4236      4.187293e-04  4.369102e-04  4.558034e-04  4.754302e-04
## ASV4842     -1.431454e-04 -1.496765e-04 -1.564873e-04 -1.635878e-04
## ASV4894     -2.559399e-04 -2.672803e-04 -2.790819e-04 -2.913597e-04
## ASV5290      3.137535e-04  3.278208e-04  3.424823e-04  3.577600e-04
## ASV5501      5.875386e-05  6.139870e-05  6.415940e-05  6.704094e-05
## ASV5795      2.140194e-04  2.239064e-04  2.342377e-04  2.450321e-04
## ASV5987     -2.559572e-04 -2.672993e-04 -2.791028e-04 -2.913828e-04
## ASV6267     -2.559145e-04 -2.672528e-04 -2.790521e-04 -2.913275e-04
## ASV6862      4.779937e-04  4.981221e-04  5.189875e-04  5.406077e-04
## ASV7145      8.191273e-05  8.505153e-05  8.828137e-05  9.160279e-05
## ASV7673     -2.558999e-04 -2.672367e-04 -2.790343e-04 -2.913079e-04
## ASV7789      9.970228e-05  1.049215e-04  1.104312e-04  1.162487e-04
## ASV7809     -3.001213e-05 -3.100722e-05 -3.200978e-05 -3.301678e-05
## ASV8002     -2.558703e-04 -2.672047e-04 -2.789999e-04 -2.912709e-04
## ASV8205      1.451843e-04  1.515908e-04  1.582632e-04  1.652115e-04
## ASV9155     -1.921348e-04 -2.005758e-04 -2.093525e-04 -2.184748e-04
## ASV9221     -3.174894e-05 -3.299207e-05 -3.426948e-05 -3.558071e-05
## ASV9311     -2.558116e-04 -2.671409e-04 -2.789304e-04 -2.911953e-04
## ASV9557     -2.557690e-04 -2.670944e-04 -2.788798e-04 -2.911401e-04
## ASV9936     -2.557264e-04 -2.670480e-04 -2.788292e-04 -2.910849e-04
## ASV1445      5.980796e-04  6.255453e-04  6.542274e-04  6.841760e-04
## ASV4232      5.071424e-04  5.308429e-04  5.556352e-04  5.815683e-04
## ASV6479      9.253398e-06  1.070123e-05  1.230685e-05  1.408503e-05
## ASV0142     -1.272410e-03 -1.327416e-03 -1.384558e-03 -1.443900e-03
## ASV0378     -4.198626e-04 -4.378917e-04 -4.566048e-04 -4.760198e-04
## ASV1122      7.896792e-04  8.259208e-04  8.637632e-04  9.032717e-04
## ASV0123     -1.245982e-03 -1.299790e-03 -1.355682e-03 -1.413721e-03
## ASV2064      1.194785e-04  1.241305e-04  1.289275e-04  1.338719e-04
## ASV4459     -1.424261e-04 -1.487780e-04 -1.553913e-04 -1.622747e-04
## ASV0448      2.375859e-04  2.495689e-04  2.621737e-04  2.754334e-04
## ASV0397      5.909742e-04  6.179395e-04  6.460804e-04  6.754435e-04
## ASV0485      8.139777e-04  8.502427e-04  8.880164e-04  9.273529e-04
## ASV1566      6.874541e-04  7.185762e-04  7.510333e-04  7.848763e-04
## ASV1365      4.422748e-04  4.622189e-04  4.830137e-04  5.046910e-04
## ASV1065      9.156911e-04  9.573362e-04  1.000786e-03  1.046111e-03
## ASV0722     -1.797003e-05 -1.866950e-05 -1.939315e-05 -2.014190e-05
## ASV12660    -4.188530e-04 -4.368453e-04 -4.555247e-04 -4.749104e-04
## ASV0223     -1.497089e-05 -1.550974e-05 -1.605932e-05 -1.661883e-05
## ASV0229      4.136970e-04  4.328985e-04  4.529669e-04  4.739390e-04
## ASV0877     -1.606100e-04 -1.676214e-04 -1.749025e-04 -1.824603e-04
## ASV0983      8.283734e-04  8.649613e-04  9.030372e-04  9.426507e-04
## ASV0626     -2.565579e-04 -2.664849e-04 -2.766900e-04 -2.871716e-04
## ASV4146     -4.812211e-05 -5.030462e-05 -5.258043e-05 -5.495313e-05
## ASV4175     -5.110063e-04 -5.339468e-04 -5.578514e-04 -5.827548e-04
## ASV2082     -4.089117e-05 -4.329195e-05 -4.585108e-05 -4.858015e-05
## ASV2272      3.693684e-04  3.862111e-04  4.037914e-04  4.221392e-04
## ASV2245     -4.480866e-04 -4.684418e-04 -4.896742e-04 -5.118173e-04
## ASV0590     -2.801009e-04 -2.937399e-04 -3.080529e-04 -3.230735e-04
## ASV0217     -3.832781e-04 -3.976303e-04 -4.123370e-04 -4.273898e-04
## ASV0416      4.004010e-04  4.169310e-04  4.340307e-04  4.517103e-04
## ASV1056      5.095909e-04  5.338768e-04  5.593144e-04  5.859573e-04
## ASV7777     -4.493383e-04 -4.699419e-04 -4.914534e-04 -5.139098e-04
## ASV0455      9.231011e-05  9.676544e-05  1.014316e-04  1.063177e-04
## ASV0604      1.110431e-04  1.172271e-04  1.237780e-04  1.307184e-04
## ASV6100     -4.150478e-04 -4.341141e-04 -4.540230e-04 -4.748091e-04
## ASV11359    -4.530783e-04 -4.732011e-04 -4.941500e-04 -5.159528e-04
## ASV6604      3.307245e-04  3.461852e-04  3.623565e-04  3.792702e-04
## ASV5004     -2.690882e-04 -2.811616e-04 -2.937410e-04 -3.068444e-04
## ASV1483     -2.521215e-04 -2.636735e-04 -2.757324e-04 -2.883186e-04
## ASV9773     -5.294271e-04 -5.536067e-04 -5.788422e-04 -6.051756e-04
## ASV4059      5.460448e-05  5.762105e-05  6.081790e-05  6.420656e-05
## ASV1193      8.567112e-04  8.955670e-04  9.360986e-04  9.783710e-04
## ASV4610     -6.360571e-05 -6.536827e-05 -6.711106e-05 -6.882570e-05
## ASV0742     -3.020736e-04 -3.140511e-04 -3.263940e-04 -3.391037e-04
## ASV1502     -1.123002e-05 -1.228021e-05 -1.342198e-05 -1.466267e-05
## ASV0195     -1.026625e-04 -1.080458e-04 -1.137229e-04 -1.197097e-04
## ASV1213      2.621019e-04  2.730943e-04  2.844795e-04  2.962655e-04
## ASV1648     -3.916343e-04 -4.094766e-04 -4.280953e-04 -4.475212e-04
## ASV6984     -2.931859e-04 -3.066018e-04 -3.206056e-04 -3.352208e-04
## ASV0396     -1.855747e-04 -1.913324e-04 -1.971136e-04 -2.029013e-04
## ASV4297      4.276747e-04  4.460779e-04  4.651915e-04  4.850364e-04
## ASV2622      9.834648e-04  1.026486e-03  1.071225e-03  1.117735e-03
## ASV3512      1.593893e-04  1.674144e-04  1.758604e-04  1.847503e-04
## ASV2411      3.481615e-04  3.644928e-04  3.815746e-04  3.994395e-04
## ASV2291     -9.295742e-05 -9.779891e-05 -1.029087e-04 -1.083028e-04
## ASV0807      4.224520e-04  4.432306e-04  4.650418e-04  4.879363e-04
## ASV1292      2.247253e-04  2.346770e-04  2.450377e-04  2.558219e-04
## ASV1035      9.610994e-05  9.977217e-05  1.035332e-04  1.073922e-04
## ASV0070     -2.251241e-04 -2.340274e-04 -2.431959e-04 -2.526292e-04
## ASV0255      9.198800e-05  9.589002e-05  9.993209e-05  1.041166e-04
## ASV0057     -1.000101e-03 -1.042535e-03 -1.086540e-03 -1.132154e-03
## ASV0077     -1.397398e-04 -1.449099e-04 -1.501983e-04 -1.556003e-04
## ASV0625      1.005368e-03  1.048873e-03  1.094067e-03  1.140998e-03
## ASV2464      4.815851e-04  5.019659e-04  5.231001e-04  5.450066e-04
## ASV1315      8.847817e-04  9.253659e-04  9.677570e-04  1.012031e-03
## ASV2673      6.655057e-04  6.970446e-04  7.300695e-04  7.646494e-04
## ASV2161      2.773675e-04  2.907086e-04  3.046957e-04  3.193600e-04
## ASV0337     -4.297263e-04 -4.490466e-04 -4.691848e-04 -4.901712e-04
## ASV7680     -5.096371e-04 -5.330027e-04 -5.573967e-04 -5.828608e-04
## ASV0611      1.113064e-03  1.164751e-03  1.218776e-03  1.275241e-03
## ASV3118     -3.796835e-04 -3.973277e-04 -4.157691e-04 -4.350416e-04
## ASV1284      4.196115e-04  4.396179e-04  4.605483e-04  4.824408e-04
## ASV0889      2.957057e-04  3.087923e-04  3.224189e-04  3.366051e-04
## ASV4649     -3.164139e-04 -3.308643e-04 -3.459460e-04 -3.616839e-04
## ASV1108     -4.132444e-04 -4.330247e-04 -4.537520e-04 -4.754713e-04
## ASV0738     -3.218064e-05 -3.112418e-05 -2.979876e-05 -2.817466e-05
## ASV0473      5.682117e-05  5.918553e-05  6.163345e-05  6.416668e-05
## ASV0598     -4.359478e-04 -4.541157e-04 -4.729265e-04 -4.923933e-04
## ASV0429      7.258384e-04  7.583498e-04  7.922198e-04  8.274962e-04
## ASV1549      7.434951e-04  7.789026e-04  8.159917e-04  8.548412e-04
## ASV1203      5.393422e-04  5.632126e-04  5.880586e-04  6.139129e-04
## ASV4532      1.622543e-05  1.645818e-05  1.666082e-05  1.682931e-05
## ASV0274     -5.276854e-04 -5.498328e-04 -5.727878e-04 -5.965703e-04
## ASV0163     -7.611032e-04 -7.931522e-04 -8.263671e-04 -8.607745e-04
## ASV1298      3.079276e-04  3.208358e-04  3.342106e-04  3.480629e-04
## ASV9424     -6.797236e-04 -7.112239e-04 -7.441437e-04 -7.785435e-04
## ASV0412      1.022478e-03  1.067994e-03  1.115398e-03  1.164759e-03
## ASV0284      4.467411e-04  4.656988e-04  4.853611e-04  5.057458e-04
## ASV0620     -3.611096e-04 -3.786627e-04 -3.970755e-04 -4.163899e-04
## ASV0153     -7.297570e-04 -7.639451e-04 -7.997063e-04 -8.371102e-04
## ASV0498      9.944744e-05  1.057124e-04  1.123905e-04  1.195083e-04
## ASV0097      5.167201e-04  5.408516e-04  5.660953e-04  5.925015e-04
## ASV0104     -2.362326e-03 -2.468582e-03 -2.579352e-03 -2.694807e-03
## ASV1282      4.297368e-04  4.498779e-04  4.709268e-04  4.929197e-04
## ASV3883     -2.454713e-04 -2.570910e-04 -2.692519e-04 -2.819781e-04
## ASV0801      2.536364e-04  2.662474e-04  2.794965e-04  2.934162e-04
## ASV1611     -9.190513e-04 -9.612387e-04 -1.005291e-03 -1.051283e-03
## ASV0227     -3.404345e-04 -3.569061e-04 -3.741768e-04 -3.922848e-04
## ASV0833      3.701204e-04  3.881865e-04  4.071412e-04  4.270276e-04
## ASV0718      8.514238e-04  8.900875e-04  9.304250e-04  9.725016e-04
## ASV1139      2.970578e-04  3.090671e-04  3.214606e-04  3.342412e-04
## ASV0766     -2.320053e-04 -2.422863e-04 -2.529887e-04 -2.641269e-04
## ASV2091      1.102405e-03  1.149454e-03  1.198284e-03  1.248945e-03
## ASV1238     -3.007157e-05 -2.925083e-05 -2.823161e-05 -2.699577e-05
## ASV9193     -1.475477e-04 -1.563744e-04 -1.657349e-04 -1.756589e-04
## ASV0290     -9.433350e-05 -9.890822e-05 -1.037025e-04 -1.087262e-04
## ASV0231      8.970190e-04  9.371771e-04  9.790225e-04  1.022617e-03
## ASV0185      2.041489e-04  2.171653e-04  2.310723e-04  2.459322e-04
## ASV2330      2.570735e-04  2.683076e-04  2.799884e-04  2.921301e-04
## ASV3119     -3.149162e-04 -3.308067e-04 -3.475250e-04 -3.651153e-04
## ASV2368     -4.218461e-04 -4.418478e-04 -4.627923e-04 -4.847235e-04
## ASV0122     -3.148838e-04 -3.283167e-04 -3.422601e-04 -3.567286e-04
## ASV1044      5.877711e-04  6.163407e-04  6.463135e-04  6.777589e-04
## ASV0160     -7.689557e-04 -8.010736e-04 -8.343401e-04 -8.687803e-04
## ASV0326      5.202757e-04  5.440014e-04  5.687623e-04  5.945991e-04
## ASV1388      9.041758e-04  9.448333e-04  9.872122e-04  1.031376e-03
## ASV0792      1.019020e-03  1.064092e-03  1.111003e-03  1.159816e-03
## ASV0036     -6.581311e-04 -6.887324e-04 -7.207210e-04 -7.541564e-04
## ASV2125      1.055039e-03  1.102371e-03  1.151699e-03  1.203097e-03
## ASV1075      2.092653e-04  2.193217e-04  2.298661e-04  2.409224e-04
## ASV0390      2.141333e-04  2.252002e-04  2.368692e-04  2.491751e-04
## ASV3790     -8.518590e-04 -8.907311e-04 -9.313068e-04 -9.736548e-04
## ASV1535     -8.976390e-05 -9.489364e-05 -1.003311e-04 -1.060951e-04
## ASV0263      1.766433e-04  1.846771e-04  1.930575e-04  2.017976e-04
## ASV0675      1.433584e-03  1.501117e-03  1.571780e-03  1.645710e-03
## ASV3348      1.435906e-04  1.508648e-04  1.585244e-04  1.665913e-04
## ASV0058     -1.314998e-03 -1.373197e-03 -1.433785e-03 -1.496847e-03
## ASV4142      3.351521e-04  3.501481e-04  3.657698e-04  3.820391e-04
## ASV0059     -1.129617e-03 -1.179320e-03 -1.231039e-03 -1.284840e-03
## ASV0013     -2.400045e-03 -2.508072e-03 -2.620697e-03 -2.738093e-03
## ASV0033     -7.188569e-04 -7.524415e-04 -7.875631e-04 -8.242890e-04
## ASV4354     -3.072217e-04 -3.208022e-04 -3.349416e-04 -3.496598e-04
## ASV0022     -7.590319e-04 -7.944625e-04 -8.315117e-04 -8.702498e-04
## ASV0134     -1.957030e-04 -2.054562e-04 -2.157080e-04 -2.264842e-04
## ASV0415     -1.309066e-04 -1.350139e-04 -1.391472e-04 -1.432959e-04
## ASV10103    -5.219432e-04 -5.457082e-04 -5.705042e-04 -5.963712e-04
## ASV1613      8.363655e-04  8.733191e-04  9.117782e-04  9.517933e-04
## ASV0135     -3.089830e-05 -3.061409e-05 -3.016135e-05 -2.951920e-05
## ASV0469     -1.042024e-03 -1.087908e-03 -1.135652e-03 -1.185318e-03
## ASV0471      7.011293e-04  7.341460e-04  7.686732e-04  8.047743e-04
## ASV0451     -1.907584e-04 -2.002352e-04 -2.101973e-04 -2.206703e-04
## ASV0747      2.781670e-04  2.919972e-04  3.065227e-04  3.217779e-04
## ASV1314     -4.117043e-04 -4.316096e-04 -4.524857e-04 -4.743805e-04
## ASV0425     -1.164412e-03 -1.214390e-03 -1.266285e-03 -1.320151e-03
## ASV0559     -6.658922e-04 -6.945914e-04 -7.244046e-04 -7.553656e-04
## ASV0148     -7.099528e-04 -7.398627e-04 -7.708649e-04 -8.029852e-04
## ASV0129     -3.337941e-04 -3.464863e-04 -3.595213e-04 -3.728958e-04
## ASV1072      3.324219e-04  3.458883e-04  3.598076e-04  3.741880e-04
## ASV2390      2.529269e-04  2.638306e-04  2.751526e-04  2.869041e-04
## ASV0548      7.729757e-04  8.083392e-04  8.452627e-04  8.838102e-04
## ASV0168     -1.142523e-03 -1.192809e-03 -1.245137e-03 -1.299577e-03
## ASV0066     -8.641713e-04 -9.031241e-04 -9.437359e-04 -9.860688e-04
## ASV0468     -3.166678e-04 -3.309108e-04 -3.457563e-04 -3.612265e-04
## ASV0172     -1.547516e-04 -1.596694e-04 -1.646225e-04 -1.695982e-04
## ASV0236     -4.078836e-04 -4.232516e-04 -4.390177e-04 -4.551760e-04
## ASV0250      6.546663e-05  7.178848e-05  7.866865e-05  8.615212e-05
## ASV0338     -3.455972e-05 -3.406426e-05 -3.337712e-05 -3.247782e-05
## ASV0450     -6.868860e-06 -7.300815e-06 -7.762723e-06 -8.256806e-06
## ASV0377      9.475980e-04  9.904738e-04  1.035191e-03  1.081820e-03
## ASV1022      2.667605e-04  2.790628e-04  2.919161e-04  3.053439e-04
## ASV6174     -6.293816e-05 -6.560787e-05 -6.837855e-05 -7.125321e-05
## ASV0786      1.000171e-04  1.040150e-04  1.081379e-04  1.123866e-04
## ASV0053     -1.150814e-03 -1.203483e-03 -1.258466e-03 -1.315854e-03
## ASV0697     -3.208875e-04 -3.344691e-04 -3.485557e-04 -3.631606e-04
## ASV0785      8.399584e-04  8.777950e-04  9.172562e-04  9.584057e-04
## ASV1967     -5.473129e-04 -5.708259e-04 -5.952424e-04 -6.205884e-04
## ASV0385     -2.413589e-04 -2.510122e-04 -2.609839e-04 -2.712798e-04
## ASV0295      1.671822e-05  1.899570e-05  2.150930e-05  2.428049e-05
## ASV0072     -8.835165e-04 -9.215346e-04 -9.610215e-04 -1.002021e-03
## ASV0157     -3.614522e-04 -3.762219e-04 -3.914776e-04 -4.072240e-04
## ASV0501      4.388297e-04  4.601242e-04  4.824385e-04  5.058181e-04
## ASV10729    -7.034171e-04 -7.359116e-04 -7.698599e-04 -8.053228e-04
## ASV1470      2.849082e-04  2.957431e-04  3.068801e-04  3.183187e-04
## ASV0050     -2.250526e-03 -2.350683e-03 -2.455003e-03 -2.563636e-03
## ASV0411     -4.894313e-05 -5.044407e-05 -5.195632e-05 -5.347691e-05
## ASV0549      4.383111e-04  4.591341e-04  4.809517e-04  5.038122e-04
## ASV0184      2.677431e-04  2.799680e-04  2.927311e-04  3.060546e-04
## ASV0705      3.323066e-04  3.481554e-04  3.647542e-04  3.821373e-04
## ASV1715      8.084564e-04  8.452498e-04  8.836430e-04  9.236992e-04
## ASV0603      1.008313e-04  1.057778e-04  1.109737e-04  1.164323e-04
## ASV0826      2.566136e-04  2.672725e-04  2.783062e-04  2.897221e-04
## ASV0034     -1.011980e-03 -1.056332e-03 -1.102455e-03 -1.150406e-03
## ASV0838      2.249987e-04  2.353825e-04  2.462239e-04  2.575408e-04
## ASV0614     -5.811378e-04 -6.070040e-04 -6.339439e-04 -6.619958e-04
## ASV0014     -2.189546e-03 -2.287433e-03 -2.389430e-03 -2.495686e-03
## ASV0585     -1.245868e-04 -1.297280e-04 -1.350500e-04 -1.405566e-04
## ASV0016     -2.239347e-03 -2.339549e-03 -2.443964e-03 -2.552750e-03
## ASV5394     -5.767642e-04 -6.032388e-04 -6.308822e-04 -6.597420e-04
## ASV0666      4.813225e-04  5.027248e-04  5.250112e-04  5.482122e-04
## ASV2085      1.707822e-04  1.766166e-04  1.825362e-04  1.885306e-04
## ASV0003     -2.044294e-03 -2.135416e-03 -2.230341e-03 -2.329206e-03
## ASV0346     -1.540585e-05 -1.408215e-05 -1.252667e-05 -1.071593e-05
## ASV0267     -3.231042e-04 -3.368751e-04 -3.511540e-04 -3.659520e-04
## ASV0353      4.852805e-04  5.100592e-04  5.361337e-04  5.635714e-04
## ASV2419      5.724809e-04  5.976229e-04  6.237776e-04  6.509781e-04
## ASV0447      2.952795e-04  3.105615e-04  3.266659e-04  3.436379e-04
## ASV0654      9.109789e-04  9.530541e-04  9.970080e-04  1.042918e-03
## ASV0151      1.509720e-04  1.590302e-04  1.675500e-04  1.765601e-04
## ASV0065     -8.146486e-04 -8.506005e-04 -8.880212e-04 -9.269610e-04
## ASV0527      6.024422e-04  6.296193e-04  6.579567e-04  6.874983e-04
## ASV4055     -2.378321e-04 -2.495174e-04 -2.617908e-04 -2.746830e-04
## ASV0166     -6.475023e-04 -6.742338e-04 -7.019035e-04 -7.305314e-04
## ASV0417     -5.777492e-04 -6.032108e-04 -6.297054e-04 -6.572674e-04
## ASV0078     -4.469726e-04 -4.657394e-04 -4.851877e-04 -5.053334e-04
## ASV0322     -5.319504e-04 -5.538492e-04 -5.765151e-04 -5.999646e-04
## ASV0156     -7.026403e-04 -7.323724e-04 -7.632183e-04 -7.952090e-04
## ASV0648     -6.825030e-04 -7.143186e-04 -7.475842e-04 -7.823627e-04
## ASV0407      4.635653e-05  4.862481e-05  5.101697e-05  5.354131e-05
## ASV2030     -1.372144e-04 -1.428149e-04 -1.486091e-04 -1.546014e-04
## ASV0300      4.235596e-04  4.447423e-04  4.670005e-04  4.903885e-04
## ASV1150     -4.756427e-05 -4.927473e-05 -5.101814e-05 -5.279215e-05
## ASV0958      4.240126e-04  4.446649e-04  4.663395e-04  4.890879e-04
## ASV0216     -6.912664e-04 -7.211067e-04 -7.521059e-04 -7.842985e-04
## ASV0446      1.017297e-03  1.065935e-03  1.116883e-03  1.170245e-03
## ASV0367     -3.380781e-04 -3.533710e-04 -3.693221e-04 -3.859571e-04
## ASV0200     -6.171950e-04 -6.447832e-04 -6.735348e-04 -7.034937e-04
## ASV0334     -2.957018e-04 -3.065926e-04 -3.177329e-04 -3.291140e-04
## ASV1311      4.441393e-04  4.640952e-04  4.848958e-04  5.065722e-04
## ASV0458      4.714860e-04  4.923773e-04  5.141283e-04  5.367688e-04
## ASV1371      1.512391e-05  1.587677e-05  1.666755e-05  1.749808e-05
## ASV0418      5.492667e-04  5.727075e-04  5.970412e-04  6.222936e-04
## ASV0004      6.809874e-04  7.111744e-04  7.426023e-04  7.753138e-04
## ASV1943      4.950991e-04  5.166598e-04  5.390774e-04  5.623793e-04
## ASV1495     -1.497163e-04 -1.582667e-04 -1.673418e-04 -1.769753e-04
## ASV0901     -8.021278e-04 -8.395966e-04 -8.787828e-04 -9.197622e-04
## ASV0628      4.552760e-04  4.751947e-04  4.959045e-04  5.174297e-04
## ASV0400      1.908682e-04  1.995591e-04  2.086209e-04  2.180669e-04
## ASV0116     -6.060566e-04 -6.341405e-04 -6.634917e-04 -6.941645e-04
## ASV0788      5.003243e-04  5.229829e-04  5.466161e-04  5.712613e-04
## ASV0117      3.313271e-04  3.473141e-04  3.640797e-04  3.816622e-04
## ASV3137      9.172066e-05  9.598356e-05  1.004417e-04  1.051038e-04
## ASV0001      8.095283e-04  8.443885e-04  8.805986e-04  9.181987e-04
## ASV1651      5.276864e-04  5.498243e-04  5.727660e-04  5.965305e-04
## ASV1692      6.036823e-04  6.321873e-04  6.620227e-04  6.932487e-04
## ASV0660      3.279754e-04  3.415066e-04  3.554911e-04  3.699335e-04
## ASV0508      3.316931e-05  3.405395e-05  3.492605e-05  3.578132e-05
## ASV1660     -2.529073e-04 -2.652019e-04 -2.780969e-04 -2.916211e-04
## ASV0233      1.325613e-04  1.387249e-04  1.451721e-04  1.519158e-04
## ASV1343     -6.034458e-04 -6.313072e-04 -6.604160e-04 -6.908248e-04
## ASV0209      5.444987e-04  5.681183e-04  5.926653e-04  6.181684e-04
## ASV0193     -6.719243e-04 -6.998955e-04 -7.288739e-04 -7.588839e-04
## ASV0357     -3.896184e-05 -3.998214e-05 -4.097804e-05 -4.194242e-05
## ASV0198      1.655988e-04  1.736397e-04  1.820685e-04  1.909030e-04
## ASV0007      7.673838e-04  8.004326e-04  8.347619e-04  8.704100e-04
## ASV1772     -7.563503e-05 -7.873783e-05 -8.194184e-05 -8.524760e-05
## ASV0009      7.227245e-04  7.537469e-04  7.859624e-04  8.194058e-04
## ASV0006      2.841441e-04  2.955448e-04  3.073140e-04  3.194565e-04
## ASV0011     -8.434066e-04 -8.824394e-04 -9.232217e-04 -9.658265e-04
## ASV0015      5.720891e-04  5.974531e-04  6.238584e-04  6.513405e-04
## ASV0017      6.049309e-04  6.316784e-04  6.595185e-04  6.884884e-04
## ASV0235     -4.983264e-04 -5.215590e-04 -5.458420e-04 -5.712193e-04
## ASV0382      1.123394e-04  1.192816e-04  1.266735e-04  1.345435e-04
## ASV2357      7.464088e-04  7.806953e-04  8.165017e-04  8.538905e-04
## ASV0567     -5.255181e-04 -5.485986e-04 -5.726178e-04 -5.976085e-04
## ASV0165      6.000759e-04  6.277417e-04  6.566395e-04  6.868200e-04
## ASV0005      1.168244e-03  1.219918e-03  1.273710e-03  1.329694e-03
## ASV0384     -4.199239e-05 -4.269339e-05 -4.331195e-05 -4.383434e-05
## ASV0002      2.530524e-04  2.648576e-04  2.771998e-04  2.901020e-04
## ASV3017      6.793863e-04  7.091424e-04  7.400919e-04  7.722733e-04
## ASV0091      2.710420e-04  2.838000e-04  2.971501e-04  3.111187e-04
## ASV0186     -7.163330e-04 -7.491272e-04 -7.833615e-04 -8.190936e-04
## ASV0370      8.464101e-05  8.918604e-05  9.399202e-05  9.907497e-05
## ASV0018      1.218733e-03  1.272829e-03  1.329161e-03  1.387808e-03
## ASV1377      1.064979e-03  1.112044e-03  1.161026e-03  1.211989e-03
## ASV0019      1.220921e-03  1.275153e-03  1.331628e-03  1.390428e-03
## ASV0023      7.176791e-05  7.362685e-05  7.545009e-05  7.722723e-05
## ASV2194      3.854161e-04  4.025764e-04  4.204636e-04  4.391063e-04
## ASV1155     -3.989624e-05 -4.105534e-05 -4.220496e-05 -4.333941e-05
## ASV0510     -4.208253e-04 -4.375895e-04 -4.548888e-04 -4.727300e-04
## ASV2371     -4.227002e-04 -4.401708e-04 -4.582508e-04 -4.769522e-04
## ASV0024      1.224387e-05  1.139222e-05  1.038691e-05  9.212865e-06
## ASV2452      5.627070e-04  5.868212e-04  6.118552e-04  6.378346e-04
## ASV2332      2.924992e-05  3.150917e-05  3.395733e-05  3.661037e-05
## ASV2591      4.661142e-05  5.037156e-05  5.443203e-05  5.881528e-05
## ASV0521      8.143005e-04  8.527482e-04  8.929836e-04  9.350867e-04
## ASV5542      2.563280e-04  2.687779e-04  2.818315e-04  2.955169e-04
## ASV0336     -3.416002e-04 -3.558179e-04 -3.705531e-04 -3.858196e-04
## ASV10102     5.619762e-04  5.882488e-04  6.157229e-04  6.444507e-04
## ASV16823    -4.114635e-04 -4.284753e-04 -4.460831e-04 -4.642991e-04
## ASV3104      4.114002e-04  4.284067e-04  4.460088e-04  4.642187e-04
## ASV0781      2.140448e-04  2.238670e-04  2.341221e-04  2.448277e-04
## ASV10899     2.185427e-04  2.299333e-04  2.419428e-04  2.546057e-04
## ASV11222    -4.113631e-04 -4.283670e-04 -4.459663e-04 -4.641733e-04
## ASV11327    -4.112998e-04 -4.282984e-04 -4.458921e-04 -4.640929e-04
## ASV12458    -4.112365e-04 -4.282299e-04 -4.458179e-04 -4.640127e-04
## ASV1636     -3.366097e-04 -3.504887e-04 -3.648490e-04 -3.797000e-04
## ASV1890     -4.137873e-04 -4.312372e-04 -4.493322e-04 -4.680890e-04
## ASV2898      9.209340e-04  9.616687e-04  1.004067e-03  1.048186e-03
## ASV8328     -4.738314e-05 -4.754642e-05 -4.754557e-05 -4.736016e-05
## ASV0709     -7.561046e-04 -7.897877e-04 -8.248669e-04 -8.613909e-04
## ASV0856      1.309484e-04  1.376072e-04  1.446160e-04  1.519936e-04
## ASV0909     -2.958471e-04 -3.070491e-04 -3.185421e-04 -3.303215e-04
## ASV0937     -5.917035e-04 -6.185564e-04 -6.465748e-04 -6.758054e-04
## ASV11390    -4.111063e-04 -4.280893e-04 -4.456661e-04 -4.638489e-04
## ASV11966     2.330569e-04  2.446374e-04  2.568030e-04  2.695833e-04
## ASV12990     1.244074e-04  1.303940e-04  1.366639e-04  1.432297e-04
## ASV14797     4.434443e-04  4.629187e-04  4.831743e-04  5.042361e-04
## ASV14904    -4.110960e-04 -4.280787e-04 -4.456552e-04 -4.638379e-04
## ASV15304     1.320696e-04  1.392873e-04  1.469198e-04  1.549914e-04
## ASV16696    -4.110481e-04 -4.280271e-04 -4.455998e-04 -4.637783e-04
## ASV1690      2.387336e-04  2.507883e-04  2.634635e-04  2.767908e-04
## ASV2029      1.183666e-03  1.236343e-03  1.291203e-03  1.348321e-03
## ASV2834      6.407091e-04  6.698073e-04  7.001657e-04  7.318335e-04
## ASV4003      2.049338e-04  2.159738e-04  2.276411e-04  2.399725e-04
## ASV4064      4.440837e-04  4.642922e-04  4.853757e-04  5.073679e-04
## ASV4294      1.762674e-04  1.858342e-04  1.959533e-04  2.066582e-04
## ASV4609     -1.361928e-05 -1.385248e-05 -1.406403e-05 -1.425065e-05
## ASV6283     -4.110563e-04 -4.280375e-04 -4.456128e-04 -4.637944e-04
## ASV6491     -4.109931e-04 -4.279690e-04 -4.455386e-04 -4.637142e-04
## ASV7453      1.879723e-04  1.978589e-04  2.082866e-04  2.192855e-04
## ASV7959      5.088617e-05  5.455709e-05  5.850066e-05  6.273636e-05
## ASV8219      4.109573e-04  4.279310e-04  4.454983e-04  4.636715e-04
## ASV8547     -4.108941e-04 -4.278625e-04 -4.454242e-04 -4.635913e-04
## ASV9319      3.030477e-04  3.175082e-04  3.326527e-04  3.485126e-04
## ASV9382     -4.108599e-04 -4.278259e-04 -4.453849e-04 -4.635492e-04
## ASV11516    -4.107968e-04 -4.277575e-04 -4.453108e-04 -4.634691e-04
## ASV14377    -4.107336e-04 -4.276891e-04 -4.452368e-04 -4.633890e-04
## ASV1867      6.413864e-04  6.711177e-04  7.021889e-04  7.346566e-04
## ASV1895     -1.378927e-04 -1.434526e-04 -1.491974e-04 -1.551304e-04
## ASV3168      2.696795e-04  2.816533e-04  2.941141e-04  3.070773e-04
## ASV4449      5.198614e-04  5.420296e-04  5.650388e-04  5.889128e-04
## ASV6596      3.293565e-04  3.458820e-04  3.632626e-04  3.815440e-04
## ASV7492     -1.392090e-04 -1.437720e-04 -1.483850e-04 -1.530385e-04
## ASV9854     -2.052310e-04 -2.132901e-04 -2.215948e-04 -2.301471e-04
## ASV6296      4.106120e-04  4.275582e-04  4.450962e-04  4.632380e-04
## ASV4201      1.666265e-04  1.761831e-04  1.863236e-04  1.970846e-04
## ASV0552      1.081900e-03  1.132422e-03  1.185248e-03  1.240476e-03
## ASV3671     -6.984991e-05 -7.161400e-05 -7.333808e-05 -7.501175e-05
## ASV3529     -7.352552e-05 -7.518175e-05 -7.677070e-05 -7.827922e-05
## ASV1060      2.668767e-04  2.791597e-04  2.919899e-04  3.053904e-04
## ASV0239     -5.810873e-04 -6.054844e-04 -6.307573e-04 -6.569243e-04
## ASV5711     -5.366019e-04 -5.594913e-04 -5.832492e-04 -6.079005e-04
## ASV4152     -7.146060e-04 -7.457578e-04 -7.781481e-04 -8.118163e-04
## ASV1461      6.393355e-04  6.668136e-04  6.953412e-04  7.249469e-04
## ASV2877      5.244881e-04  5.476039e-04  5.716536e-04  5.966675e-04
## ASV0012      4.026976e-04  4.214725e-04  4.410997e-04  4.616156e-04
## ASV9823      1.069038e-04  1.100947e-04  1.133045e-04  1.165272e-04
## ASV0008      4.376317e-04  4.578335e-04  4.789363e-04  5.009772e-04
## ASV7832     -4.412961e-04 -4.604888e-04 -4.804438e-04 -5.011859e-04
## ASV1915      4.702315e-05  4.996213e-05  5.309287e-05  5.642748e-05
## ASV0055      3.034223e-04  3.167413e-04  3.305913e-04  3.449887e-04
## ASV0032      7.458499e-04  7.788351e-04  8.131720e-04  8.489073e-04
## ASV2977     -5.980851e-04 -6.239604e-04 -6.508453e-04 -6.787702e-04
## ASV0466      6.003254e-04  6.256944e-04  6.519969e-04  6.792558e-04
## ASV3866      6.649361e-04  6.955325e-04  7.274862e-04  7.608526e-04
## ASV0040      8.801823e-04  9.207383e-04  9.630972e-04  1.007333e-03
## ASV0496     -6.823807e-05 -7.296237e-05 -7.803540e-05 -8.348322e-05
## ASV0052      1.064057e-03  1.111733e-03  1.161414e-03  1.213173e-03
## ASV3828     -6.458997e-04 -6.742601e-04 -7.037717e-04 -7.344745e-04
## ASV1930      4.175544e-04  4.367932e-04  4.568818e-04  4.778540e-04
## ASV2126      6.627278e-04  6.924094e-04  7.233360e-04  7.555523e-04
## ASV0793      4.094568e-04  4.290767e-04  4.496318e-04  4.711653e-04
## ASV0299     -2.697178e-04 -2.807496e-04 -2.921530e-04 -3.039339e-04
## ASV0208      6.470873e-04  6.780718e-04  7.105333e-04  7.445405e-04
## ASV0511     -3.234265e-04 -3.364848e-04 -3.499645e-04 -3.638697e-04
## ASV1123     -4.280054e-04 -4.458590e-04 -4.643490e-04 -4.834891e-04
## ASV0099     -2.274395e-04 -2.367952e-04 -2.464709e-04 -2.564717e-04
## ASV0752     -6.379069e-05 -6.760439e-05 -7.166022e-05 -7.597370e-05
## ASV0883      1.157911e-05  1.252926e-05  1.355612e-05  1.466548e-05
## ASV0683      5.694737e-04  5.963920e-04  6.245669e-04  6.540549e-04
## ASV4117     -6.459644e-04 -6.741447e-04 -7.034488e-04 -7.339133e-04
## ASV2172      2.484033e-04  2.597563e-04  2.716058e-04  2.839713e-04
## ASV0330     -4.386203e-04 -4.582433e-04 -4.786970e-04 -5.000132e-04
## ASV0728      4.301557e-04  4.502443e-04  4.712448e-04  4.931957e-04
## ASV0499      8.601967e-04  9.009531e-04  9.436287e-04  9.883126e-04
## ASV0120     -9.295827e-04 -9.714945e-04 -1.015186e-03 -1.060723e-03
## ASV1446      6.230781e-05  6.391616e-05  6.548745e-05  6.701126e-05
## ASV17171    -6.164041e-04 -6.435048e-04 -6.717054e-04 -7.010433e-04
## ASV0533      1.866898e-04  1.957962e-04  2.053532e-04  2.153834e-04
## ASV2495     -2.588830e-04 -2.710337e-04 -2.837535e-04 -2.970693e-04
## ASV5582      2.090755e-04  2.174918e-04  2.261780e-04  2.351366e-04
## ASV1488      2.461065e-04  2.590656e-04  2.727089e-04  2.870700e-04
## ASV0682      6.050025e-04  6.339289e-04  6.642400e-04  6.960017e-04
## ASV0068     -3.878927e-05 -4.119906e-05 -4.376495e-05 -4.649672e-05
## ASV1987     -3.365798e-04 -3.534220e-04 -3.711293e-04 -3.897472e-04
## ASV0035      9.816084e-05  1.011481e-04  1.041299e-04  1.070939e-04
## ASV7192     -4.062483e-04 -4.233146e-04 -4.410002e-04 -4.593195e-04
## ASV0873      5.173737e-05  5.315304e-05  5.455384e-05  5.593352e-05
## ASV4749      1.965337e-05  1.895103e-05  1.807446e-05  1.700417e-05
## ASV2174      3.564450e-04  3.702301e-04  3.844342e-04  3.990625e-04
## ASV1476     -3.423679e-04 -3.576400e-04 -3.735554e-04 -3.901386e-04
## ASV0740     -8.639885e-04 -9.044323e-04 -9.467317e-04 -9.909679e-04
## ASV0170      1.782069e-04  1.861844e-04  1.944997e-04  2.031655e-04
## ASV2466     -7.665421e-04 -8.009328e-04 -8.367820e-04 -8.741452e-04
## ASV1709      5.864899e-04  6.121992e-04  6.389422e-04  6.667528e-04
## ASV6170     -4.660361e-04 -4.842503e-04 -5.030512e-04 -5.224511e-04
## ASV3673      5.792147e-04  6.038348e-04  6.294074e-04  6.559638e-04
## ASV1745      1.711989e-05  1.683709e-05  1.647307e-05  1.602141e-05
## ASV0380     -3.558979e-04 -3.688180e-04 -3.820701e-04 -3.956541e-04
## ASV0426     -1.139475e-04 -1.181280e-04 -1.224133e-04 -1.268021e-04
## ASV0202     -1.020167e-04 -1.041483e-04 -1.061518e-04 -1.080033e-04
## ASV6350     -4.640891e-04 -4.822642e-04 -5.010295e-04 -5.203978e-04
## ASV0713     -3.726537e-04 -3.896650e-04 -4.074229e-04 -4.259578e-04
## ASV1822      9.186132e-05  9.697610e-05  1.023810e-04  1.080917e-04
## ASV4569      5.755142e-04  6.005896e-04  6.266780e-04  6.538152e-04
## ASV0030     -1.451265e-04 -1.525004e-04 -1.602475e-04 -1.683852e-04
## ASV0331      2.568511e-04  2.697085e-04  2.832265e-04  2.974399e-04
## ASV2981      6.181575e-04  6.473927e-04  6.779793e-04  7.099757e-04
## ASV0828     -4.170550e-04 -4.372298e-04 -4.583780e-04 -4.805451e-04
## ASV2440      9.626632e-04  1.007719e-03  1.054834e-03  1.104099e-03
## ASV3006     -3.629406e-04 -3.762621e-04 -3.899419e-04 -4.039816e-04
## ASV3875     -3.628924e-04 -3.762106e-04 -3.898866e-04 -4.039224e-04
## ASV4511      2.433179e-04  2.550379e-04  2.673251e-04  2.802068e-04
## ASV4700     -3.628448e-04 -3.761595e-04 -3.898319e-04 -4.038639e-04
## ASV5804     -3.627967e-04 -3.761079e-04 -3.897767e-04 -4.038048e-04
## ASV6826      4.476370e-04  4.689171e-04  4.912009e-04  5.145347e-04
## ASV7280      3.982927e-04  4.180240e-04  4.387268e-04  4.604461e-04
## ASV7535     -3.627823e-04 -3.760933e-04 -3.897618e-04 -4.037899e-04
## ASV0651     -4.126108e-04 -4.301056e-04 -4.482415e-04 -4.670331e-04
## ASV0913      5.797249e-04  6.068982e-04  6.353253e-04  6.650622e-04
## ASV10832    -3.627371e-04 -3.760449e-04 -3.897100e-04 -4.037345e-04
## ASV1117     -7.976840e-04 -8.325801e-04 -8.688907e-04 -9.066647e-04
## ASV11329     2.358603e-04  2.492268e-04  2.633805e-04  2.783675e-04
## ASV13209     1.454117e-05  1.765486e-05  2.106979e-05  2.480645e-05
## ASV1345      1.280592e-04  1.350463e-04  1.424081e-04  1.501621e-04
## ASV1719     -3.626738e-04 -3.759779e-04 -3.896392e-04 -4.036597e-04
## ASV1886      4.513186e-04  4.708469e-04  4.911610e-04  5.122896e-04
## ASV2158     -6.637375e-05 -6.678817e-05 -6.704526e-05 -6.712981e-05
## ASV2189      4.980234e-04  5.204360e-04  5.438081e-04  5.681771e-04
## ASV2257      3.635046e-04  3.794363e-04  3.960288e-04  4.133079e-04
## ASV2283      3.625653e-04  3.758612e-04  3.895139e-04  4.035251e-04
## ASV2328      3.625173e-04  3.758097e-04  3.894587e-04  4.034661e-04
## ASV2434     -5.785071e-04 -6.028779e-04 -6.281829e-04 -6.544533e-04
## ASV2648      3.624038e-04  3.756873e-04  3.893267e-04  4.033238e-04
## ASV2698      5.905710e-04  6.176496e-04  6.459326e-04  6.754711e-04
## ASV2775      6.742375e-04  7.021189e-04  7.309947e-04  7.608886e-04
## ASV3171      3.622949e-04  3.755699e-04  3.892002e-04  4.031876e-04
## ASV3227      4.970361e-04  5.172976e-04  5.382533e-04  5.599172e-04
## ASV3397      5.594692e-05  5.942143e-05  6.310100e-05  6.699524e-05
## ASV3444      5.524314e-04  5.752024e-04  5.988076e-04  6.232723e-04
## ASV3556      3.621628e-04  3.754275e-04  3.890470e-04  4.030228e-04
## ASV3606     -3.621149e-04 -3.753762e-04 -3.889919e-04 -4.029639e-04
## ASV4190      5.210405e-04  5.448580e-04  5.697331e-04  5.957108e-04
## ASV4197      5.728169e-04  5.965233e-04  6.210911e-04  6.465439e-04
## ASV4722      5.339277e-04  5.575532e-04  5.821604e-04  6.077854e-04
## ASV4765      1.528277e-04  1.604785e-04  1.684936e-04  1.768871e-04
## ASV4809      3.619856e-04  3.752368e-04  3.888416e-04  4.028019e-04
## ASV4846      3.920560e-04  4.102134e-04  4.291754e-04  4.489738e-04
## ASV4903     -6.693167e-05 -6.741323e-05 -6.774271e-05 -6.790509e-05
## ASV4944     -3.619471e-04 -3.751962e-04 -3.887990e-04 -4.027571e-04
## ASV5151     -1.937055e-04 -2.049701e-04 -2.169088e-04 -2.295606e-04
## ASV5413     -3.619208e-04 -3.751687e-04 -3.887703e-04 -4.027274e-04
## ASV5537     -3.618729e-04 -3.751174e-04 -3.887154e-04 -4.026686e-04
## ASV5688      3.618251e-04  3.750661e-04  3.886605e-04  4.026098e-04
## ASV5752      2.238972e-04  2.354411e-04  2.475725e-04  2.603182e-04
## ASV6122     -3.617964e-04 -3.750358e-04 -3.886286e-04 -4.025763e-04
## ASV6135      3.617486e-04  3.749846e-04  3.885737e-04  4.025175e-04
## ASV6188     -3.617007e-04 -3.749333e-04 -3.885188e-04 -4.024587e-04
## ASV6216      5.712810e-04  5.948879e-04  6.193525e-04  6.446987e-04
## ASV6242      3.615922e-04  3.748163e-04  3.883928e-04  4.023232e-04
## ASV6383      3.615444e-04  3.747651e-04  3.883379e-04  4.022645e-04
## ASV6781      3.614966e-04  3.747139e-04  3.882831e-04  4.022058e-04
## ASV6799     -3.614489e-04 -3.746627e-04 -3.882283e-04 -4.021472e-04
## ASV7374     -3.614011e-04 -3.746115e-04 -3.881735e-04 -4.020885e-04
## ASV7539     -3.613534e-04 -3.745604e-04 -3.881187e-04 -4.020299e-04
## ASV8591     -3.613057e-04 -3.745092e-04 -3.880639e-04 -4.019712e-04
## ASV8637      3.612580e-04  3.744581e-04  3.880091e-04  4.019126e-04
## ASV12796    -3.612103e-04 -3.744070e-04 -3.879544e-04 -4.018540e-04
## ASV1934      4.729339e-04  4.946156e-04  5.172552e-04  5.408920e-04
## ASV22549     6.348843e-05  6.882417e-05  7.456093e-05  8.072390e-05
## ASV29857    -3.611720e-04 -3.743666e-04 -3.879118e-04 -4.018092e-04
## ASV3215      5.841096e-04  6.116288e-04  6.404336e-04  6.705833e-04
## ASV3236     -3.611202e-04 -3.743110e-04 -3.878521e-04 -4.017453e-04
## ASV3954     -3.610726e-04 -3.742599e-04 -3.877974e-04 -4.016867e-04
## ASV4850      3.610249e-04  3.742088e-04  3.877427e-04  4.016282e-04
## ASV5225      3.609773e-04  3.741578e-04  3.876881e-04  4.015697e-04
## ASV5532     -3.609296e-04 -3.741067e-04 -3.876334e-04 -4.015112e-04
## ASV7258      9.128144e-05  9.853031e-05  1.063263e-04  1.147065e-04
## ASV9474     -1.835822e-04 -1.887418e-04 -1.939038e-04 -1.990558e-04
## ASV11857    -3.608814e-04 -3.740564e-04 -3.875810e-04 -4.014568e-04
## ASV1202     -3.608338e-04 -3.740053e-04 -3.875263e-04 -4.013983e-04
## ASV14742     3.164691e-04  3.328727e-04  3.501471e-04  3.683382e-04
## ASV16652     1.666144e-04  1.751154e-04  1.840318e-04  1.933802e-04
## ASV2019      5.727854e-04  5.969616e-04  6.220543e-04  6.480916e-04
## ASV2410     -5.518711e-04 -5.766457e-04 -6.024882e-04 -6.294422e-04
## ASV2718      6.124770e-04  6.417921e-04  6.724881e-04  7.046262e-04
## ASV2738      6.384670e-04  6.646260e-04  6.916982e-04  7.197038e-04
## ASV2876      3.607295e-04  3.738937e-04  3.874069e-04  4.012706e-04
## ASV3177      3.606820e-04  3.738427e-04  3.873523e-04  4.012122e-04
## ASV4367      3.606344e-04  3.737917e-04  3.872977e-04  4.011538e-04
## ASV4635      1.779654e-04  1.886360e-04  1.999478e-04  2.119359e-04
## ASV4896      7.723951e-05  8.398968e-05  9.127774e-05  9.914159e-05
## ASV4907      3.374724e-04  3.553975e-04  3.742941e-04  3.942135e-04
## ASV5230     -3.606659e-04 -3.738283e-04 -3.873401e-04 -4.012027e-04
## ASV6509     -3.606183e-04 -3.737773e-04 -3.872855e-04 -4.011443e-04
## ASV7376     -3.605708e-04 -3.737264e-04 -3.872309e-04 -4.010859e-04
## ASV8163     -3.605232e-04 -3.736754e-04 -3.871764e-04 -4.010275e-04
## ASV8195     -3.604757e-04 -3.736245e-04 -3.871218e-04 -4.009692e-04
## ASV8923      2.730805e-04  2.870053e-04  3.016398e-04  3.170181e-04
## ASV9666     -3.129933e-04 -3.239161e-04 -3.350845e-04 -3.464953e-04
## ASV1482      3.883926e-04  4.068662e-04  4.262014e-04  4.464358e-04
## ASV2726      5.065453e-04  5.308591e-04  5.563213e-04  5.829828e-04
## ASV3281     -3.604408e-04 -3.735885e-04 -3.870847e-04 -4.009311e-04
## ASV4235     -3.603933e-04 -3.735375e-04 -3.870302e-04 -4.008728e-04
## ASV4808      5.790145e-04  6.033521e-04  6.286127e-04  6.548258e-04
## ASV4861     -5.770771e-04 -6.013451e-04 -6.265414e-04 -6.526972e-04
## ASV5276      5.712553e-04  5.951196e-04  6.198698e-04  6.455320e-04
## ASV5837      5.172098e-04  5.412263e-04  5.663400e-04  5.925999e-04
## ASV7098      5.260309e-04  5.502684e-04  5.755981e-04  6.020675e-04
## ASV8451     -3.601437e-04 -3.732675e-04 -3.867382e-04 -4.005572e-04
## ASV8694     -3.600963e-04 -3.732167e-04 -3.866837e-04 -4.004989e-04
## ASV0905     -2.251329e-04 -2.355561e-04 -2.464161e-04 -2.577252e-04
## ASV2900      4.552786e-04  4.729327e-04  4.911462e-04  5.099300e-04
## ASV3963     -3.484787e-04 -3.610523e-04 -3.739472e-04 -3.871638e-04
## ASV0041     -4.674015e-04 -4.899026e-04 -5.134743e-04 -5.381648e-04
## ASV1865      4.858970e-04  5.104086e-04  5.361672e-04  5.632342e-04
## ASV1140      3.877247e-04  4.063464e-04  4.258293e-04  4.462081e-04
## ASV1179      5.432491e-04  5.686083e-04  5.951167e-04  6.228225e-04
## ASV0279      7.373185e-04  7.697918e-04  8.036073e-04  8.388148e-04
## ASV0043     -8.532270e-05 -9.091888e-05 -9.691455e-05 -1.033395e-04
## ASV2097     -3.958095e-04 -4.122050e-04 -4.292115e-04 -4.468486e-04
## ASV0309     -1.981121e-04 -2.061267e-04 -2.144115e-04 -2.229717e-04
## ASV0607      9.256191e-04  9.686998e-04  1.013733e-03  1.060801e-03
## ASV0025     -9.844589e-04 -1.030617e-03 -1.078883e-03 -1.129346e-03
## ASV2284     -1.260409e-04 -1.295852e-04 -1.331249e-04 -1.366501e-04
## ASV0556      1.843476e-04  1.942805e-04  2.047664e-04  2.158354e-04
## ASV5040      2.932241e-04  3.032388e-04  3.134589e-04  3.238797e-04
## ASV2924     -3.186967e-04 -3.299776e-04 -3.415290e-04 -3.533496e-04
## ASV1331      1.167301e-03  1.219920e-03  1.274799e-03  1.332026e-03
## ASV0506     -5.056679e-04 -5.262595e-04 -5.475520e-04 -5.695586e-04
## ASV1514      8.795118e-04  9.193257e-04  9.608429e-04  1.004127e-03
## ASV2144      7.340278e-04  7.668838e-04  8.011317e-04  8.368248e-04
## ASV2265      9.814756e-04  1.025918e-03  1.072273e-03  1.120616e-03
## ASV5156      1.865781e-04  1.930788e-04  1.997181e-04  2.064927e-04
## ASV5534      1.419664e-04  1.461295e-04  1.503039e-04  1.544795e-04
## ASV5747     -6.357626e-05 -6.888341e-05 -7.459655e-05 -8.074232e-05
## ASV6657      4.262753e-04  4.442629e-04  4.629290e-04  4.822939e-04
## ASV0658     -4.722469e-04 -4.914715e-04 -5.113535e-04 -5.319059e-04
## ASV0716      1.213631e-04  1.264134e-04  1.316439e-04  1.370588e-04
## ASV1657      1.860371e-04  1.922942e-04  1.986597e-04  2.051274e-04
## ASV1885     -4.036188e-05 -4.443376e-05 -4.884525e-05 -5.361965e-05
## ASV2333      1.061203e-03  1.107796e-03  1.156279e-03  1.206717e-03
## ASV3375      3.759365e-04  3.911453e-04  4.068776e-04  4.231458e-04
## ASV4317      4.198783e-04  4.390847e-04  4.591509e-04  4.801150e-04
## ASV9599     -6.377647e-05 -6.909921e-05 -7.482902e-05 -8.099258e-05
## ASV0175     -1.425412e-03 -1.487697e-03 -1.552459e-03 -1.619776e-03
## ASV1032      4.032365e-04  4.194238e-04  4.361512e-04  4.534289e-04
## ASV1235     -7.928219e-06 -9.892783e-06 -1.206231e-05 -1.445244e-05
## ASV1262      1.262351e-03  1.318245e-03  1.376440e-03  1.437014e-03
## ASV1320      3.385557e-04  3.560132e-04  3.743952e-04  3.937508e-04
## ASV13797     4.564187e-04  4.759452e-04  4.962346e-04  5.173122e-04
## ASV1491      2.709474e-04  2.853026e-04  3.004250e-04  3.163527e-04
## ASV15014    -6.384084e-05 -6.916699e-05 -7.490023e-05 -8.106722e-05
## ASV1510      4.082920e-04  4.283201e-04  4.493158e-04  4.713220e-04
## ASV1551     -1.532742e-04 -1.598145e-04 -1.666037e-04 -1.736490e-04
## ASV1919      6.463458e-06  9.181158e-06  1.219363e-05  1.552331e-05
## ASV2114      2.138966e-04  2.222287e-04  2.308338e-04  2.397193e-04
## ASV21486    -6.378142e-05 -6.910012e-05 -7.482504e-05 -8.098273e-05
## ASV2448      6.324245e-04  6.594132e-04  6.874376e-04  7.165291e-04
## ASV2589      2.919955e-04  3.037781e-04  3.159641e-04  3.285629e-04
## ASV2608      5.084226e-04  5.305336e-04  5.535334e-04  5.774529e-04
## ASV2786      4.109245e-04  4.291867e-04  4.482260e-04  4.680741e-04
## ASV2827      5.366690e-04  5.601837e-04  5.846505e-04  6.101020e-04
## ASV2872      4.183950e-04  4.352118e-04  4.525832e-04  4.705184e-04
## ASV3125      5.026011e-04  5.233918e-04  5.449297e-04  5.672340e-04
## ASV3247      5.504380e-04  5.734220e-04  5.972438e-04  6.219251e-04
## ASV3451     -6.409647e-05 -6.944169e-05 -7.519522e-05 -8.138376e-05
## ASV3465     -9.663716e-05 -1.033595e-04 -1.105474e-04 -1.182306e-04
## ASV3809      3.091786e-04  3.213821e-04  3.339734e-04  3.469578e-04
## ASV4006      6.852819e-04  7.137656e-04  7.432693e-04  7.738174e-04
## ASV4046      4.836013e-04  5.035387e-04  5.241864e-04  5.455622e-04
## ASV4938     -6.746071e-05 -7.296425e-05 -7.888327e-05 -8.524477e-05
## ASV5435     -6.416498e-05 -6.951352e-05 -7.527031e-05 -8.146204e-05
## ASV5605      1.824684e-04  1.886002e-04  1.948372e-04  2.011730e-04
## ASV5635     -6.416553e-05 -6.951292e-05 -7.526834e-05 -8.145841e-05
## ASV5743      6.228762e-04  6.495438e-04  6.772484e-04  7.060233e-04
## ASV6627     -6.421265e-05 -6.956342e-05 -7.532241e-05 -8.151626e-05
## ASV6785     -6.419337e-05 -6.954168e-05 -7.529791e-05 -8.148867e-05
## ASV7368      6.972536e-04  7.287757e-04  7.616654e-04  7.959781e-04
## ASV9118      1.732238e-04  1.792406e-04  1.853880e-04  1.916637e-04
## ASV9135      1.257922e-04  1.292689e-04  1.327330e-04  1.361740e-04
## ASV9435      3.065755e-04  3.178627e-04  3.294318e-04  3.412792e-04
## ASV9671     -6.427534e-05 -6.962911e-05 -7.539105e-05 -8.158778e-05
## ASV0387     -6.804774e-04 -7.086766e-04 -7.378790e-04 -7.681077e-04
## ASV0454     -6.834428e-04 -7.123182e-04 -7.422646e-04 -7.733100e-04
## ASV0751     -4.382571e-04 -4.560478e-04 -4.744401e-04 -4.934454e-04
## ASV1081      1.911729e-04  1.998367e-04  2.088658e-04  2.182728e-04
## ASV1332      3.786440e-04  3.950533e-04  4.121022e-04  4.298097e-04
## ASV2659      6.192345e-04  6.473871e-04  6.767394e-04  7.073341e-04
## ASV2979      6.118875e-04  6.369602e-04  6.628985e-04  6.897200e-04
## ASV4184      2.280353e-04  2.355501e-04  2.431718e-04  2.508897e-04
## ASV6198      2.129446e-04  2.216007e-04  2.305658e-04  2.398493e-04
## ASV7454      3.979671e-04  4.142879e-04  4.311739e-04  4.486370e-04
## ASV8198      1.372845e-04  1.408975e-04  1.444696e-04  1.479862e-04
## ASV0855      9.283784e-04  9.702922e-04  1.014003e-03  1.059582e-03
## ASV10092     3.779298e-04  3.936470e-04  4.099432e-04  4.268353e-04
## ASV1532      5.289047e-04  5.543649e-04  5.810543e-04  6.090318e-04
## ASV2553      1.231065e-03  1.286521e-03  1.344345e-03  1.404630e-03
## ASV2741      5.166098e-04  5.415182e-04  5.676116e-04  5.949430e-04
## ASV4095      2.968774e-04  3.123133e-04  3.285547e-04  3.456408e-04
## ASV5295      3.322340e-04  3.446727e-04  3.574457e-04  3.705521e-04
## ASV5787     -6.445974e-05 -6.982541e-05 -7.559973e-05 -8.180931e-05
## ASV9455      4.623452e-04  4.817924e-04  5.019726e-04  5.229084e-04
## ASV10879     4.893776e-04  5.108609e-04  5.332317e-04  5.565234e-04
## ASV3997      3.614432e-04  3.789485e-04  3.972804e-04  4.164743e-04
## ASV6760      6.691790e-05  6.724693e-05  6.738971e-05  6.732634e-05
## ASV6990      3.410781e-04  3.548780e-04  3.691553e-04  3.839218e-04
## ASV9560      2.048472e-04  2.125136e-04  2.204011e-04  2.285127e-04
## ASV0220      2.060674e-04  2.155258e-04  2.254005e-04  2.357079e-04
## ASV2518      4.905877e-04  5.131577e-04  5.367301e-04  5.613463e-04
## ASV3615      7.498222e-04  7.828133e-04  8.171548e-04  8.528946e-04
## ASV0075      1.701394e-04  1.772878e-04  1.847009e-04  1.923861e-04
## ASV8070      6.399174e-05  6.451987e-05  6.489722e-05  6.510715e-05
## ASV1658      3.473008e-04  3.618760e-04  3.769972e-04  3.926808e-04
## ASV0773      5.764464e-04  6.011962e-04  6.269126e-04  6.536266e-04
## ASV0799      2.244968e-05  2.359801e-05  2.480676e-05  2.607919e-05
## ASV1839     -1.112211e-04 -1.152555e-04 -1.193751e-04 -1.235755e-04
## ASV0265      5.967088e-04  6.263651e-04  6.575156e-04  6.902350e-04
## ASV3741      2.128899e-04  2.217918e-04  2.310119e-04  2.405568e-04
## ASV0847      7.838120e-04  8.188484e-04  8.553533e-04  8.933803e-04
## ASV1026      8.347801e-04  8.716787e-04  9.100860e-04  9.500532e-04
## ASV1222     -2.313810e-04 -2.394669e-04 -2.477311e-04 -2.561703e-04
## ASV0729      1.195837e-04  1.250670e-04  1.307921e-04  1.367684e-04
## ASV0143     -6.202100e-04 -6.461646e-04 -6.730668e-04 -7.009408e-04
## ASV1328      2.003830e-04  2.104809e-04  2.210987e-04  2.322632e-04
## ASV9078     -1.966325e-04 -2.082165e-04 -2.204992e-04 -2.335206e-04
## ASV0027     -9.401033e-04 -9.840655e-04 -1.030024e-03 -1.078062e-03
## ASV0546     -3.806956e-04 -3.962194e-04 -4.122765e-04 -4.288781e-04
## ASV1136      1.016606e-03  1.061824e-03  1.108939e-03  1.158023e-03
## ASV3081      4.840020e-04  5.059102e-04  5.287819e-04  5.526586e-04
## ASV0531      2.284804e-04  2.396994e-04  2.514662e-04  2.638063e-04
## ASV2525      2.751877e-04  2.869625e-04  2.991957e-04  3.119021e-04
## ASV1083     -8.355577e-05 -8.575296e-05 -8.792955e-05 -9.007775e-05
## ASV0424      1.739845e-04  1.815648e-04  1.894477e-04  1.976433e-04
## ASV0644      5.320562e-05  5.763768e-05  6.240781e-05  6.753806e-05
## ASV6007     -6.326901e-05 -6.854674e-05 -7.422816e-05 -8.033980e-05
## ASV0564      2.689035e-04  2.824209e-04  2.966187e-04  3.115292e-04
## ASV1938      2.455807e-04  2.547443e-04  2.641571e-04  2.738198e-04
## ASV6516     -6.220945e-04 -6.499239e-04 -6.789286e-04 -7.091531e-04
## ASV0503     -6.945388e-04 -7.227032e-04 -7.518136e-04 -7.818862e-04
## ASV6913     -7.213795e-04 -7.524076e-04 -7.846710e-04 -8.182136e-04
## ASV0164     -5.854799e-04 -6.130811e-04 -6.419674e-04 -6.721967e-04
## ASV1576      6.895735e-04  7.205108e-04  7.527789e-04  7.864318e-04
## ASV1725      3.655934e-04  3.840758e-04  4.034907e-04  4.238823e-04
## ASV4501      2.654218e-04  2.751431e-04  2.851024e-04  2.952959e-04
## ASV10678    -6.091304e-04 -6.361958e-04 -6.643857e-04 -6.937409e-04
## ASV0944      5.142674e-04  5.386051e-04  5.640829e-04  5.907530e-04
## ASV2292      7.741918e-04  8.078285e-04  8.427974e-04  8.791412e-04
## ASV1090      5.124164e-04  5.354152e-04  5.593951e-04  5.843939e-04
## ASV9117     -2.199234e-04 -2.276641e-04 -2.355805e-04 -2.436702e-04
## ASV0285     -3.433512e-04 -3.615544e-04 -3.807498e-04 -4.009911e-04
## ASV0463     -4.785027e-04 -4.981441e-04 -5.184632e-04 -5.394729e-04
## ASV3199      4.096325e-04  4.260884e-04  4.430921e-04  4.606539e-04
## ASV0150     -1.912643e-04 -2.010358e-04 -2.113121e-04 -2.221182e-04
## ASV6583     -2.264200e-04 -2.348220e-04 -2.434639e-04 -2.523493e-04
## ASV0392      4.046967e-04  4.227132e-04  4.414807e-04  4.610265e-04
## ASV14007    -4.843282e-04 -5.051072e-04 -5.266824e-04 -5.490767e-04
## ASV0177     -2.569157e-04 -2.670046e-04 -2.773989e-04 -2.881003e-04
## ASV6448     -2.479472e-04 -2.618374e-04 -2.765239e-04 -2.920502e-04
## ASV5399     -1.166883e-04 -1.243669e-04 -1.325515e-04 -1.412725e-04
## ASV0277     -1.039987e-04 -1.088018e-04 -1.138137e-04 -1.190417e-04
## ASV2599      1.629095e-04  1.683429e-04  1.738731e-04  1.794961e-04
## ASV13465    -1.223609e-04 -1.257677e-04 -1.291679e-04 -1.325519e-04
## ASV2412      2.596587e-04  2.715173e-04  2.838983e-04  2.968234e-04
## ASV0423      5.251113e-04  5.507385e-04  5.776306e-04  6.058504e-04
## ASV5187      2.789839e-04  2.890182e-04  2.993029e-04  3.098373e-04
## ASV0701     -1.222153e-03 -1.278691e-03 -1.337765e-03 -1.399483e-03
## ASV4248      3.169487e-04  3.332166e-04  3.503267e-04  3.683206e-04
## ASV0519      5.190343e-04  5.437677e-04  5.696579e-04  5.967559e-04
## ASV0764      9.618831e-05  1.015829e-04  1.072932e-04  1.133376e-04
## ASV5385     -6.363573e-04 -6.657930e-04 -6.965577e-04 -7.287093e-04
## ASV3021     -3.366563e-04 -3.496803e-04 -3.631094e-04 -3.769503e-04
## ASV4119     -1.786886e-04 -1.850498e-04 -1.915664e-04 -1.982382e-04
## ASV2534      8.856888e-05  9.189874e-05  9.532577e-05  9.885114e-05
## ASV1061      5.104596e-04  5.365975e-04  5.641172e-04  5.930933e-04
## ASV0670      6.812453e-04  7.128648e-04  7.459182e-04  7.804680e-04
## ASV1384      3.107940e-04  3.265636e-04  3.431330e-04  3.605401e-04
## ASV1981      6.425769e-04  6.728950e-04  7.046143e-04  7.377958e-04
## ASV9632     -1.623391e-04 -1.667276e-04 -1.710949e-04 -1.754277e-04
## ASV4564      1.588303e-04  1.663972e-04  1.743176e-04  1.826067e-04
## ASV5289     -1.498610e-04 -1.571725e-04 -1.648503e-04 -1.729138e-04
## ASV0516      1.279517e-03  1.337995e-03  1.399027e-03  1.462714e-03
## ASV1463     -4.517894e-04 -4.713463e-04 -4.916679e-04 -5.127777e-04
## ASV0969      2.061521e-04  2.147176e-04  2.235835e-04  2.327552e-04
## ASV1113     -5.945654e-04 -6.216930e-04 -6.500063e-04 -6.795525e-04
## ASV1234     -5.529418e-05 -6.062031e-05 -6.642563e-05 -7.275006e-05
## ASV3814      4.396694e-05  4.288168e-05  4.152963e-05  3.988703e-05
## ASV1000      5.974771e-04  6.236079e-04  6.507816e-04  6.790315e-04
## ASV0079     -6.410427e-05 -6.823212e-05 -7.264165e-05 -7.735222e-05
## ASV0145      1.864365e-04  1.935412e-04  2.008546e-04  2.083787e-04
## ASV0457     -7.559704e-04 -7.889182e-04 -8.231733e-04 -8.587772e-04
## ASV1485      2.561021e-04  2.684460e-04  2.813900e-04  2.949636e-04
## ASV0535     -1.495849e-04 -1.553973e-04 -1.613919e-04 -1.675720e-04
## ASV0259     -5.032962e-04 -5.259545e-04 -5.495676e-04 -5.741692e-04
## ASV0570      4.774210e-05  5.106472e-05  5.462557e-05  5.844119e-05
## ASV0906      6.361709e-04  6.638815e-04  6.926949e-04  7.226468e-04
## ASV1748     -4.095880e-04 -4.304976e-04 -4.524870e-04 -4.756099e-04
## ASV5520     -2.538349e-04 -2.677751e-04 -2.824961e-04 -2.980396e-04
## ASV2288     -7.551696e-04 -7.884879e-04 -8.231653e-04 -8.592482e-04
## ASV1887     -1.709060e-04 -1.807145e-04 -1.910804e-04 -2.020317e-04
## ASV0374     -2.202671e-04 -2.290267e-04 -2.380651e-04 -2.473856e-04
## ASV0823      7.071315e-04  7.372118e-04  7.684432e-04  8.008608e-04
## ASV0717      3.676738e-04  3.844914e-04  4.020450e-04  4.203638e-04
## ASV0431      2.579546e-04  2.694104e-04  2.813432e-04  2.937707e-04
## ASV1030      1.095418e-03  1.147663e-03  1.202375e-03  1.259666e-03
## ASV1082     -1.583585e-04 -1.656466e-04 -1.732549e-04 -1.811958e-04
## ASV2684      1.232450e-04  1.306595e-04  1.385164e-04  1.468392e-04
## ASV0051      9.429255e-04  9.862813e-04  1.031567e-03  1.078865e-03
## ASV0513      5.316515e-05  5.639613e-05  5.984049e-05  6.351304e-05
## ASV0581      1.219128e-03  1.275488e-03  1.334371e-03  1.395884e-03
## ASV7282      2.229587e-04  2.347026e-04  2.470922e-04  2.601642e-04
## ASV3009     -6.634013e-04 -6.937000e-04 -7.253233e-04 -7.583235e-04
## ASV2106     -3.184084e-04 -3.315391e-04 -3.451498e-04 -3.592548e-04
## ASV1012      2.257183e-04  2.370752e-04  2.489998e-04  2.615186e-04
## ASV0921     -8.686461e-06 -8.533961e-06 -8.321850e-06 -8.042598e-06
## ASV0010     -9.556513e-04 -1.000390e-03 -1.047167e-03 -1.096069e-03
## ASV1178      3.072510e-05  3.285123e-05  3.512092e-05  3.754264e-05
## ASV2848     -4.894156e-04 -5.105966e-04 -5.326323e-04 -5.555539e-04
## ASV0586      1.384121e-03  1.448383e-03  1.515549e-03  1.585744e-03
## ASV4225      1.042714e-04  1.120288e-04  1.203369e-04  1.292302e-04
## ASV2156     -5.790992e-04 -6.060034e-04 -6.341244e-04 -6.635142e-04
## ASV9778     -3.576612e-04 -3.736778e-04 -3.903717e-04 -4.077686e-04
## ASV0493     -7.719892e-04 -8.054489e-04 -8.402312e-04 -8.763789e-04
## ASV3770      1.089030e-04  1.120090e-04  1.151216e-04  1.182337e-04
## ASV0470      9.670868e-04  1.010982e-03  1.056779e-03  1.104555e-03
## ASV0262     -4.355476e-04 -4.578818e-04 -4.813815e-04 -5.061065e-04
## ASV0998      6.011484e-04  6.290876e-04  6.582952e-04  6.888259e-04
## ASV7708     -1.475775e-04 -1.533887e-04 -1.593749e-04 -1.655365e-04
## ASV0453     -1.472282e-05 -1.521745e-05 -1.573318e-05 -1.627250e-05
## ASV0044      1.212151e-03  1.267050e-03  1.324314e-03  1.384035e-03
## ASV5490      1.865498e-04  1.944140e-04  2.025608e-04  2.109955e-04
## ASV2638      7.512370e-05  7.967709e-05  8.450800e-05  8.963178e-05
## ASV0829     -9.198518e-05 -9.486540e-05 -9.777970e-05 -1.007244e-04
## ASV0601      2.289482e-04  2.400619e-04  2.517193e-04  2.639470e-04
## ASV0234      5.397608e-04  5.646080e-04  5.905626e-04  6.176709e-04
## ASV0133      6.956317e-04  7.272122e-04  7.601565e-04  7.945174e-04
## ASV0323      7.550388e-04  7.908764e-04  8.284088e-04  8.677152e-04
## ASV0854     -5.602217e-05 -5.818083e-05 -6.040021e-05 -6.268004e-05
## ASV0110      9.380256e-04  9.813036e-04  1.026516e-03  1.073744e-03
## ASV0816      4.872573e-05  5.073176e-05  5.280944e-05  5.496070e-05
## ASV1031     -1.303752e-04 -1.353733e-04 -1.405225e-04 -1.458252e-04
## ASV0144     -3.842519e-04 -4.016762e-04 -4.198555e-04 -4.388195e-04
## ASV0020     -1.877775e-04 -1.980304e-04 -2.088891e-04 -2.203924e-04
## ASV0962     -3.126257e-04 -3.267025e-04 -3.413728e-04 -3.566579e-04
## ASV0794      6.445022e-04  6.760759e-04  7.091942e-04  7.439299e-04
## ASV7117     -3.050533e-04 -3.184176e-04 -3.323227e-04 -3.467871e-04
## ASV1008     -2.366951e-04 -2.483045e-04 -2.604911e-04 -2.732837e-04
## ASV0096      1.009068e-03  1.055585e-03  1.104176e-03  1.154928e-03
## ASV0128     -6.251564e-04 -6.558182e-04 -6.880149e-04 -7.218252e-04
## ASV5232      4.861161e-04  5.097465e-04  5.345239e-04  5.605024e-04
## ASV0031      3.073196e-05  3.169695e-05  3.266878e-05  3.364516e-05
## ASV1744     -6.013524e-05 -6.282644e-05 -6.565100e-05 -6.861791e-05
## ASV0289      5.636886e-04  5.896937e-04  6.168713e-04  6.452724e-04
## ASV7413     -1.619178e-04 -1.719284e-04 -1.825748e-04 -1.938956e-04
## ASV0822     -6.587211e-04 -6.868997e-04 -7.161506e-04 -7.465039e-04
## ASV8111     -5.777642e-04 -6.026696e-04 -6.285694e-04 -6.554991e-04
## ASV0687      4.433747e-04  4.648807e-04  4.874222e-04  5.110466e-04
## ASV0112      1.440339e-04  1.496121e-04  1.553491e-04  1.612444e-04
## ASV0987      3.590126e-04  3.767083e-04  3.952974e-04  4.148262e-04
## ASV5332     -1.511541e-04 -1.560938e-04 -1.611299e-04 -1.662618e-04
## ASV1129     -4.445263e-04 -4.650364e-04 -4.864728e-04 -5.088761e-04
## ASV1274     -1.430535e-04 -1.495226e-04 -1.562702e-04 -1.633073e-04
## ASV0119      8.215417e-04  8.593418e-04  8.988220e-04  9.400517e-04
## ASV0890      2.050492e-04  2.145804e-04  2.245377e-04  2.349384e-04
## ASV0848      1.198117e-03  1.253619e-03  1.311618e-03  1.372218e-03
## ASV5944     -6.402726e-04 -6.690507e-04 -6.990531e-04 -7.303267e-04
## ASV19741    -6.088055e-04 -6.360613e-04 -6.644692e-04 -6.940726e-04
## ASV0504     -6.892527e-04 -7.190167e-04 -7.499469e-04 -7.820802e-04
## ASV2146     -4.384136e-04 -4.571173e-04 -4.765591e-04 -4.967656e-04
## ASV0089     -3.814900e-04 -3.991794e-04 -4.176629e-04 -4.369735e-04
## ASV2301     -4.186491e-04 -4.383184e-04 -4.588965e-04 -4.804240e-04
## ASV2982      1.866945e-04  1.980211e-04  2.100423e-04  2.227975e-04
## ASV0891     -5.143080e-04 -5.374708e-04 -5.616184e-04 -5.867877e-04
## ASV0093      8.437520e-04  8.821809e-04  9.222867e-04  9.641364e-04
## ASV0042      4.090521e-04  4.276953e-04  4.471526e-04  4.674569e-04
## ASV0980      5.484814e-04  5.723491e-04  5.971557e-04  6.229295e-04
## ASV0069     -1.397462e-04 -1.464936e-04 -1.535659e-04 -1.609781e-04
## ASV1364     -8.812815e-05 -9.167516e-05 -9.533498e-05 -9.910846e-05
## ASV0524     -1.678025e-04 -1.761417e-04 -1.849057e-04 -1.941165e-04
## ASV0435      1.134445e-03  1.187273e-03  1.242505e-03  1.300245e-03
## ASV0517     -4.651186e-04 -4.868345e-04 -5.095443e-04 -5.332917e-04
## ASV3167     -2.129443e-04 -2.236452e-04 -2.348921e-04 -2.467126e-04
## ASV4280     -6.413396e-05 -6.667075e-05 -6.929088e-05 -7.199628e-05
## ASV1158      2.967236e-04  3.116878e-04  3.273934e-04  3.438733e-04
## ASV2214      1.976219e-04  2.062282e-04  2.151940e-04  2.245346e-04
## ASV0544     -2.652516e-04 -2.781175e-04 -2.916118e-04 -3.057651e-04
## ASV5326     -4.623112e-05 -4.833422e-05 -5.053327e-05 -5.283309e-05
## ASV3765     -6.699606e-04 -7.005628e-04 -7.325015e-04 -7.658294e-04
## ASV4646     -3.513288e-05 -3.839673e-05 -4.192256e-05 -4.572795e-05
## ASV0090      6.368157e-05  6.596640e-05  6.829517e-05  7.066471e-05
## ASV3680      5.881753e-04  6.125597e-04  6.378049e-04  6.639292e-04
## ASV0111      1.004280e-04  1.044539e-04  1.086058e-04  1.128844e-04
## ASV0768      3.974333e-04  4.164467e-04  4.363729e-04  4.572558e-04
## ASV4862     -1.327346e-05 -1.327215e-05 -1.321368e-05 -1.309041e-05
## ASV1742     -4.798457e-04 -4.999221e-04 -5.207435e-04 -5.423313e-04
## ASV3701     -5.835094e-05 -5.999002e-05 -6.162867e-05 -6.326258e-05
## ASV2386     -3.071315e-04 -3.211078e-04 -3.356885e-04 -3.508969e-04
## ASV0375     -6.980673e-04 -7.285475e-04 -7.602596e-04 -7.932462e-04
## ASV2796      1.725014e-04  1.794520e-04  1.866461e-04  1.940907e-04
## ASV1369      4.796925e-04  5.007327e-04  5.226471e-04  5.454698e-04
## ASV10272    -4.420050e-04 -4.616917e-04 -4.821943e-04 -5.035413e-04
## ASV10354    -4.419313e-04 -4.616113e-04 -4.821066e-04 -5.034457e-04
## ASV1067     -3.312711e-05 -3.456502e-05 -3.605862e-05 -3.760946e-05
## ASV1900      9.433797e-04  9.872499e-04  1.033111e-03  1.081047e-03
## ASV4079     -1.644812e-04 -1.724073e-04 -1.807123e-04 -1.894134e-04
## ASV4149      6.050095e-04  6.303959e-04  6.567042e-04  6.839563e-04
## ASV5140     -4.418569e-04 -4.615300e-04 -4.820177e-04 -5.033487e-04
## ASV10782    -8.368603e-06 -7.878199e-06 -7.286218e-06 -6.581348e-06
## ASV4273     -9.540719e-05 -9.901651e-05 -1.027157e-04 -1.065022e-04
## ASV8121      4.313047e-04  4.512471e-04  4.720889e-04  4.938691e-04
## ASV8438     -4.417968e-04 -4.614649e-04 -4.819474e-04 -5.032726e-04
## ASV9390     -4.417231e-04 -4.613846e-04 -4.818598e-04 -5.031770e-04
## ASV1340      6.275005e-04  6.569567e-04  6.877706e-04  7.200020e-04
## ASV2650     -6.505927e-04 -6.789621e-04 -7.084552e-04 -7.391069e-04
## ASV4674      3.381408e-04  3.535131e-04  3.695495e-04  3.862757e-04
## ASV10492    -2.246310e-05 -2.330869e-05 -2.417738e-05 -2.506920e-05
## ASV11430    -4.416181e-04 -4.612703e-04 -4.817355e-04 -5.030421e-04
## ASV12135    -4.415444e-04 -4.611900e-04 -4.816480e-04 -5.029466e-04
## ASV14970    -4.414709e-04 -4.611097e-04 -4.815604e-04 -5.028512e-04
## ASV1954      5.119969e-04  5.354926e-04  5.600222e-04  5.856270e-04
## ASV2613      7.929856e-04  8.288984e-04  8.663555e-04  9.054163e-04
## ASV2757      3.047632e-04  3.176384e-04  3.309898e-04  3.448297e-04
## ASV2909     -4.787809e-04 -5.013659e-04 -5.250056e-04 -5.497481e-04
## ASV2954     -8.887197e-05 -9.258719e-05 -9.643417e-05 -1.004155e-04
## ASV2969      4.515043e-04  4.731240e-04  4.957793e-04  5.195192e-04
## ASV3410      9.692722e-05  1.019331e-04  1.072100e-04  1.127733e-04
## ASV3575      2.307688e-04  2.412517e-04  2.521923e-04  2.636092e-04
## ASV4275      4.981373e-04  5.196170e-04  5.419262e-04  5.650888e-04
## ASV4652      9.371287e-05  9.865047e-05  1.038614e-04  1.093613e-04
## ASV4761      4.980693e-04  5.195565e-04  5.418697e-04  5.650319e-04
## ASV6003      4.021800e-04  4.217929e-04  4.423775e-04  4.639829e-04
## ASV6110     -4.416351e-04 -4.612897e-04 -4.817575e-04 -5.030669e-04
## ASV7427      2.869138e-04  2.997906e-04  3.132101e-04  3.271922e-04
## ASV8092     -4.415875e-04 -4.612378e-04 -4.817009e-04 -5.030053e-04
## ASV8169     -4.415139e-04 -4.611575e-04 -4.816133e-04 -5.029098e-04
## ASV9693      1.955115e-04  2.045015e-04  2.138883e-04  2.236877e-04
## ASV10913     2.173505e-04  2.277825e-04  2.387154e-04  2.501727e-04
## ASV1979     -6.793695e-05 -7.069014e-05 -7.353576e-05 -7.647552e-05
## ASV3772      5.439377e-04  5.679725e-04  5.929927e-04  6.190330e-04
## ASV0113      1.081114e-04  1.128131e-04  1.177028e-04  1.227867e-04
## ASV1800     -4.241203e-05 -4.414344e-05 -4.592262e-05 -4.774793e-05
## ASV2335     -5.692945e-04 -5.940520e-04 -6.198140e-04 -6.466170e-04
## ASV0692      1.906528e-04  1.994519e-04  2.086406e-04  2.182342e-04
## ASV1120      2.471363e-04  2.586209e-04  2.706270e-04  2.831771e-04
## ASV1434     -1.302732e-03 -1.362887e-03 -1.425738e-03 -1.491396e-03
## ASV0076     -1.465322e-04 -1.535640e-04 -1.609307e-04 -1.686477e-04
## ASV0361      9.758681e-04  1.021077e-03  1.068323e-03  1.117693e-03
## ASV2231     -3.404351e-04 -3.577966e-04 -3.760770e-04 -3.953262e-04
## ASV2018     -1.507546e-05 -1.590075e-05 -1.677706e-05 -1.770811e-05
## ASV1529      8.253224e-04  8.645086e-04  9.055461e-04  9.485212e-04
## ASV0841     -3.480659e-05 -3.586547e-05 -3.692391e-05 -3.797789e-05
## ASV2556     -4.818003e-04 -5.033667e-04 -5.258376e-04 -5.492458e-04
## ASV2777      5.886266e-04  6.131035e-04  6.384485e-04  6.646803e-04
## ASV0355      5.016593e-04  5.248191e-04  5.490178e-04  5.742998e-04
## ASV5169     -6.964729e-04 -7.282473e-04 -7.614043e-04 -7.959978e-04
## ASV3091      3.422397e-04  3.586187e-04  3.757830e-04  3.937703e-04
## ASV2435      4.928450e-04  5.152440e-04  5.386118e-04  5.629857e-04
## ASV6822     -3.069032e-04 -3.203406e-04 -3.343132e-04 -3.488379e-04
## ASV12605    -7.572426e-04 -7.917497e-04 -8.277594e-04 -8.653310e-04
## ASV0286     -4.985226e-04 -5.210872e-04 -5.446388e-04 -5.692191e-04
## ASV0074     -3.102017e-05 -3.345955e-05 -3.609070e-05 -3.892796e-05
## ASV2485     -4.477856e-05 -4.762480e-05 -5.067876e-05 -5.395719e-05
## ASV1233     -9.675626e-04 -1.012214e-03 -1.058870e-03 -1.107617e-03
## ASV0356     -4.503680e-04 -4.702551e-04 -4.909656e-04 -5.125298e-04
## ASV2918     -5.785684e-04 -6.045051e-04 -6.315391e-04 -6.597116e-04
## ASV1427     -9.616212e-07 -1.302787e-06 -1.687383e-06 -2.119916e-06
## ASV1409      5.691222e-04  5.961207e-04  6.243923e-04  6.539962e-04
## ASV0770      1.753798e-04  1.826773e-04  1.902290e-04  1.980391e-04
## ASV1403     -6.741350e-04 -7.046467e-04 -7.364698e-04 -7.696550e-04
## ASV0314     -3.671007e-04 -3.838571e-04 -4.013407e-04 -4.195795e-04
## ASV0187     -1.393153e-06 -2.337627e-06 -3.391957e-06 -4.565338e-06
## ASV0313     -4.957918e-04 -5.180929e-04 -5.413391e-04 -5.655655e-04
## ASV1087      8.554089e-04  8.947140e-04  9.357625e-04  9.786264e-04
## ASV1970      4.958706e-05  5.179920e-05  5.410673e-05  5.651377e-05
## ASV0754      6.906041e-04  7.224350e-04  7.556865e-04  7.904181e-04
## ASV3775     -4.763022e-04 -4.987752e-04 -5.222970e-04 -5.469151e-04
## ASV0132      1.982458e-04  2.072599e-04  2.166647e-04  2.264754e-04
## ASV2329     -1.471437e-04 -1.553176e-04 -1.639516e-04 -1.730698e-04
## ASV0561      5.932498e-04  6.199370e-04  6.477540e-04  6.767425e-04
## ASV0130     -7.312542e-04 -7.652064e-04 -8.006892e-04 -8.377672e-04
## ASV0226      8.192594e-04  8.567703e-04  8.959298e-04  9.368043e-04
## ASV12648    -5.644523e-04 -5.894560e-04 -6.155123e-04 -6.426628e-04
## ASV0204      8.166776e-04  8.540563e-04  8.930765e-04  9.338041e-04
## ASV0767      1.390042e-04  1.446688e-04  1.505188e-04  1.565560e-04
## ASV0335     -4.466653e-04 -4.672139e-04 -4.886709e-04 -5.110729e-04
## ASV5901     -1.268081e-04 -1.319259e-04 -1.372233e-04 -1.427052e-04
## ASV0596     -1.721433e-04 -1.792128e-04 -1.865215e-04 -1.940727e-04
## ASV9271      1.927205e-04  2.034314e-04  2.147556e-04  2.267273e-04
## ASV0904      7.332262e-04  7.676737e-04  8.037149e-04  8.414212e-04
## ASV15270    -2.167574e-04 -2.282450e-04 -2.403417e-04 -2.530772e-04
## ASV0990     -2.058919e-04 -2.156136e-04 -2.257895e-04 -2.364404e-04
## ASV0155     -4.376490e-04 -4.577294e-04 -4.786980e-04 -5.005913e-04
## ASV0086     -6.555817e-06 -6.884733e-06 -7.230331e-06 -7.593433e-06
## ASV2581     -3.404870e-05 -3.537334e-05 -3.673005e-05 -3.811715e-05
## ASV1579     -5.166994e-04 -5.413191e-04 -5.671043e-04 -5.941090e-04
## ASV7730     -3.305373e-05 -3.567637e-05 -3.848093e-05 -4.147676e-05
## ASV0897      2.187217e-04  2.292465e-04  2.402793e-04  2.518444e-04
## ASV1975      9.908233e-04  1.036455e-03  1.084129e-03  1.133933e-03
##                                                                    
## (Intercept) -2.909500e-06 -4.473242e-06 -6.395174e-06 -8.736843e-06
## ASV1236      5.253756e-04  5.477264e-04  5.709138e-04  5.949597e-04
## ASV0421     -9.502037e-04 -9.915962e-04 -1.034625e-03 -1.079339e-03
## ASV0691     -7.895080e-04 -8.215566e-04 -8.546767e-04 -8.888858e-04
## ASV0899      1.622987e-05  1.857070e-05  2.113598e-05  2.394258e-05
## ASV1004      1.069193e-03  1.115247e-03  1.163070e-03  1.212711e-03
## ASV1041     -7.319733e-04 -7.638817e-04 -7.970461e-04 -8.315037e-04
## ASV1058      9.979594e-04  1.041207e-03  1.086146e-03  1.132826e-03
## ASV12542     3.003544e-04  3.127980e-04  3.256814e-04  3.390141e-04
## ASV1294      1.171457e-03  1.223025e-03  1.276676e-03  1.332480e-03
## ASV13113     4.420710e-04  4.632521e-04  4.854534e-04  5.087243e-04
## ASV1318      1.014407e-03  1.058482e-03  1.104287e-03  1.151873e-03
## ASV2269     -3.043409e-04 -3.176329e-04 -3.314478e-04 -3.458011e-04
## ASV2542      6.757389e-04  7.071099e-04  7.398981e-04  7.741640e-04
## ASV2660     -5.804255e-04 -6.052000e-04 -6.309062e-04 -6.575686e-04
## ASV2737     -3.908608e-05 -4.134066e-05 -4.372639e-05 -4.625029e-05
## ASV2840      7.680323e-04  8.004879e-04  8.341347e-04  8.690011e-04
## ASV3053      3.958178e-05  4.114042e-05  4.275058e-05  4.441342e-05
## ASV3077      2.405210e-04  2.508452e-04  2.615678e-04  2.727004e-04
## ASV3134      8.823788e-04  9.241243e-04  9.678319e-04  1.013593e-03
## ASV3140      3.840271e-04  4.017729e-04  4.203038e-04  4.396510e-04
## ASV3579      1.636712e-04  1.721750e-04  1.811442e-04  1.906055e-04
## ASV6119     -3.042257e-04 -3.175078e-04 -3.313119e-04 -3.456536e-04
## ASV7557     -3.041655e-04 -3.174422e-04 -3.312405e-04 -3.455759e-04
## ASV8422      1.558303e-04  1.619734e-04  1.683114e-04  1.748469e-04
## ASV1086     -8.167943e-05 -8.505762e-05 -8.855770e-05 -9.218285e-05
## ASV1310      5.743090e-04  5.993743e-04  6.254312e-04  6.525100e-04
## ASV15750    -1.420654e-04 -1.480567e-04 -1.542609e-04 -1.606819e-04
## ASV16905    -3.041388e-04 -3.174130e-04 -3.312087e-04 -3.455411e-04
## ASV2033      5.842210e-04  6.112064e-04  6.393975e-04  6.688442e-04
## ASV2089      2.091954e-04  2.183795e-04  2.279275e-04  2.378504e-04
## ASV2127      8.211730e-04  8.567025e-04  8.936170e-04  9.319581e-04
## ASV2725      9.182435e-04  9.569686e-04  9.971145e-04  1.038716e-03
## ASV2804     -3.041246e-04 -3.173978e-04 -3.311924e-04 -3.455237e-04
## ASV3075      5.930411e-04  6.191059e-04  6.462320e-04  6.744561e-04
## ASV3327      5.738779e-04  6.004619e-04  6.282459e-04  6.572814e-04
## ASV3342      6.193848e-04  6.474891e-04  6.768022e-04  7.073701e-04
## ASV3532     -5.617844e-04 -5.873871e-04 -6.141029e-04 -6.419755e-04
## ASV3600      7.012227e-04  7.327011e-04  7.655134e-04  7.997096e-04
## ASV4013      5.826743e-04  6.081516e-04  6.346447e-04  6.621857e-04
## ASV4136      5.678556e-04  5.919532e-04  6.169493e-04  6.428677e-04
## ASV4195      3.040395e-04  3.173052e-04  3.310918e-04  3.454145e-04
## ASV4407     -3.039793e-04 -3.172397e-04 -3.310205e-04 -3.453369e-04
## ASV4717      4.260998e-06  3.748180e-06  3.162127e-06  2.496931e-06
## ASV6794      2.924455e-04  3.040794e-04  3.160879e-04  3.284765e-04
## ASV8324     -3.039540e-04 -3.172117e-04 -3.309895e-04 -3.453025e-04
## ASV8981     -7.640675e-05 -7.916316e-05 -8.197173e-05 -8.482842e-05
## ASV9859      2.523038e-04  2.650071e-04  2.783767e-04  2.924492e-04
## ASV0936     -4.793796e-04 -5.005857e-04 -5.226619e-04 -5.456382e-04
## ASV12683    -5.357914e-05 -5.624376e-05 -5.903715e-05 -6.196474e-05
## ASV1293      6.933500e-04  7.230804e-04  7.539428e-04  7.859685e-04
## ASV13055    -7.115030e-05 -7.395349e-05 -7.683469e-05 -7.979274e-05
## ASV17063    -3.038611e-04 -3.171115e-04 -3.308816e-04 -3.451864e-04
## ASV2228      3.038011e-04  3.170461e-04  3.308103e-04  3.451089e-04
## ASV2769     -5.340731e-05 -5.530760e-05 -5.724242e-05 -5.920907e-05
## ASV2803      1.317271e-04  1.367770e-04  1.419734e-04  1.473172e-04
## ASV2896      3.860066e-04  4.034996e-04  4.217580e-04  4.408140e-04
## ASV3062      1.268601e-04  1.334089e-04  1.403119e-04  1.475893e-04
## ASV3107      4.686153e-04  4.899191e-04  5.121493e-04  5.353428e-04
## ASV3265      9.044787e-04  9.433855e-04  9.837863e-04  1.025724e-03
## ASV3666     -2.145258e-05 -2.245337e-05 -2.349773e-05 -2.458728e-05
## ASV4497      2.164377e-04  2.259148e-04  2.357744e-04  2.460292e-04
## ASV6914     -1.108255e-04 -1.159412e-04 -1.212807e-04 -1.268527e-04
## ASV0576     -1.040127e-03 -1.083094e-03 -1.127565e-03 -1.173570e-03
## ASV0673      3.042940e-04  3.192245e-04  3.348870e-04  3.513156e-04
## ASV0772      3.245887e-04  3.388672e-04  3.537293e-04  3.691954e-04
## ASV0862     -2.556441e-04 -2.661383e-04 -2.769911e-04 -2.882087e-04
## ASV0898      2.840817e-04  2.977074e-04  3.119812e-04  3.269326e-04
## ASV0910      6.083192e-04  6.370275e-04  6.670710e-04  6.985094e-04
## ASV0964     -3.870328e-04 -4.035865e-04 -4.207680e-04 -4.385944e-04
## ASV10059     2.904886e-04  3.046075e-04  3.194253e-04  3.349776e-04
## ASV10263    -3.041293e-04 -3.174044e-04 -3.312013e-04 -3.455355e-04
## ASV1088      3.226496e-04  3.379874e-04  3.540586e-04  3.708988e-04
## ASV1101      5.296117e-04  5.530158e-04  5.773673e-04  6.026967e-04
## ASV1183      3.450225e-04  3.606720e-04  3.769920e-04  3.940077e-04
## ASV11956     1.153168e-04  1.194408e-04  1.236576e-04  1.279649e-04
## ASV12774    -5.139222e-05 -5.399808e-05 -5.673618e-05 -5.961293e-05
## ASV1321      1.501010e-04  1.580451e-04  1.664301e-04  1.752810e-04
## ASV13793    -3.040548e-04 -3.173230e-04 -3.311125e-04 -3.454386e-04
## ASV14482    -3.550104e-05 -3.749413e-05 -3.959821e-05 -4.181874e-05
## ASV15483     2.186770e-04  2.287492e-04  2.392742e-04  2.502714e-04
## ASV2062      1.348306e-03  1.408132e-03  1.470422e-03  1.535259e-03
## ASV2132      6.279899e-04  6.569802e-04  6.872702e-04  7.189147e-04
## ASV2413      8.573757e-04  8.944482e-04  9.329688e-04  9.729816e-04
## ASV2490      5.497893e-04  5.726042e-04  5.962227e-04  6.206611e-04
## ASV2594      3.127927e-04  3.267241e-04  3.412474e-04  3.563864e-04
## ASV2822     -3.041570e-04 -3.174350e-04 -3.312351e-04 -3.455728e-04
## ASV2863      5.204361e-04  5.426337e-04  5.656672e-04  5.895593e-04
## ASV2910      6.763286e-04  7.050807e-04  7.349103e-04  7.658461e-04
## ASV2980      2.489503e-04  2.596561e-04  2.707669e-04  2.822930e-04
## ASV3307      3.040567e-04  3.173257e-04  3.311162e-04  3.454435e-04
## ASV3474      4.941553e-04  5.174810e-04  5.418942e-04  5.674441e-04
## ASV3502      9.997820e-04  1.044459e-03  1.091008e-03  1.139495e-03
## ASV4236      4.958119e-04  5.169699e-04  5.389257e-04  5.617004e-04
## ASV4842     -1.709883e-04 -1.786991e-04 -1.867307e-04 -1.950936e-04
## ASV4894     -3.041289e-04 -3.174048e-04 -3.312028e-04 -3.455384e-04
## ASV5290      3.736766e-04  3.902552e-04  4.075196e-04  4.254940e-04
## ASV5501      7.004854e-05  7.318767e-05  7.646402e-05  7.988356e-05
## ASV5795      2.563092e-04  2.680891e-04  2.803930e-04  2.932425e-04
## ASV5987     -3.041543e-04 -3.174328e-04 -3.312337e-04 -3.455724e-04
## ASV6267     -3.040941e-04 -3.173673e-04 -3.311623e-04 -3.454947e-04
## ASV6862      5.630006e-04  5.861837e-04  6.101740e-04  6.349883e-04
## ASV7145      9.501617e-05  9.852178e-05  1.021197e-04  1.058100e-04
## ASV7673     -3.040725e-04 -3.173434e-04 -3.311360e-04 -3.454658e-04
## ASV7789      1.223922e-04  1.288810e-04  1.357358e-04  1.429783e-04
## ASV7809     -3.402482e-05 -3.503004e-05 -3.602819e-05 -3.701449e-05
## ASV8002     -3.040327e-04 -3.173007e-04 -3.310902e-04 -3.454167e-04
## ASV8205      1.724460e-04  1.799773e-04  1.878164e-04  1.959748e-04
## ASV9155     -2.279530e-04 -2.377971e-04 -2.480172e-04 -2.586232e-04
## ASV9221     -3.692515e-05 -3.830199e-05 -3.971027e-05 -4.114881e-05
## ASV9311     -3.039505e-04 -3.172114e-04 -3.309932e-04 -3.453113e-04
## ASV9557     -3.038904e-04 -3.171459e-04 -3.309219e-04 -3.452338e-04
## ASV9936     -3.038303e-04 -3.170804e-04 -3.308506e-04 -3.451562e-04
## ASV1445      7.154427e-04  7.480810e-04  7.821461e-04  8.176951e-04
## ASV4232      6.086935e-04  6.370644e-04  6.667366e-04  6.977685e-04
## ASV6479      1.605177e-05  1.822437e-05  2.062150e-05  2.326334e-05
## ASV0142     -1.505504e-03 -1.569433e-03 -1.635751e-03 -1.704520e-03
## ASV0378     -4.961541e-04 -5.170248e-04 -5.386488e-04 -5.610419e-04
## ASV1122      9.445133e-04  9.875576e-04  1.032476e-03  1.079343e-03
## ASV0123     -1.473966e-03 -1.536479e-03 -1.601320e-03 -1.668551e-03
## ASV2064      1.389658e-04  1.442113e-04  1.496104e-04  1.551650e-04
## ASV4459     -1.694372e-04 -1.768878e-04 -1.846355e-04 -1.926897e-04
## ASV0448      2.893825e-04  3.040573e-04  3.194960e-04  3.357387e-04
## ASV0397      7.060764e-04  7.380285e-04  7.713504e-04  8.060944e-04
## ASV0485      9.683077e-04  1.010937e-03  1.055299e-03  1.101453e-03
## ASV1566      8.201569e-04  8.569285e-04  8.952457e-04  9.351642e-04
## ASV1365      5.272839e-04  5.508259e-04  5.753515e-04  6.008960e-04
## ASV1065      1.093383e-03  1.142676e-03  1.194069e-03  1.247639e-03
## ASV0722     -2.091672e-05 -2.171867e-05 -2.254892e-05 -2.340874e-05
## ASV12660    -4.950214e-04 -5.158767e-04 -5.374950e-04 -5.598948e-04
## ASV0223     -1.718736e-05 -1.776378e-05 -1.834680e-05 -1.893490e-05
## ASV0229      4.958533e-04  5.187495e-04  5.426686e-04  5.676534e-04
## ASV0877     -1.903012e-04 -1.984319e-04 -2.068586e-04 -2.155872e-04
## ASV0983      9.838520e-04  1.026692e-03  1.071222e-03  1.117494e-03
## ASV0626     -2.979268e-04 -3.089516e-04 -3.202408e-04 -3.317880e-04
## ASV4146     -5.742642e-05 -6.000418e-05 -6.269041e-05 -6.548928e-05
## ASV4175     -6.086922e-04 -6.356998e-04 -6.638143e-04 -6.930731e-04
## ASV2082     -5.149161e-05 -5.459888e-05 -5.791637e-05 -6.145957e-05
## ASV2272      4.412854e-04  4.612620e-04  4.821018e-04  5.038390e-04
## ASV2245     -5.349055e-04 -5.589741e-04 -5.840594e-04 -6.101984e-04
## ASV0590     -3.388373e-04 -3.553812e-04 -3.727442e-04 -3.909672e-04
## ASV0217     -4.427780e-04 -4.584889e-04 -4.745074e-04 -4.908157e-04
## ASV0416      4.699791e-04  4.888456e-04  5.083177e-04  5.284020e-04
## ASV1056      6.138612e-04  6.430841e-04  6.736865e-04  7.057312e-04
## ASV7777     -5.373491e-04 -5.618109e-04 -5.873357e-04 -6.139658e-04
## ASV0455      1.114332e-04  1.167879e-04  1.223915e-04  1.282544e-04
## ASV0604      1.380720e-04  1.458641e-04  1.541211e-04  1.628712e-04
## ASV6100     -4.965077e-04 -5.191555e-04 -5.427906e-04 -5.674521e-04
## ASV11359    -5.386379e-04 -5.622340e-04 -5.867701e-04 -6.122756e-04
## ASV6604      3.969591e-04  4.154575e-04  4.348011e-04  4.550271e-04
## ASV5004     -3.204903e-04 -3.346974e-04 -3.494846e-04 -3.648715e-04
## ASV1483     -3.014529e-04 -3.151570e-04 -3.294531e-04 -3.443640e-04
## ASV9773     -6.326500e-04 -6.613098e-04 -6.912010e-04 -7.223707e-04
## ASV4059      6.779931e-05  7.160922e-05  7.565020e-05  7.993702e-05
## ASV1193      1.022451e-03  1.068406e-03  1.116308e-03  1.166228e-03
## ASV4610     -7.050300e-05 -7.213291e-05 -7.370455e-05 -7.520609e-05
## ASV0742     -3.521808e-04 -3.656247e-04 -3.794336e-04 -3.936046e-04
## ASV1502     -1.601016e-05 -1.747290e-05 -1.905989e-05 -2.078075e-05
## ASV0195     -1.260234e-04 -1.326816e-04 -1.397030e-04 -1.471070e-04
## ASV1213      3.084600e-04  3.210700e-04  3.341025e-04  3.475633e-04
## ASV1648     -4.677860e-04 -4.889223e-04 -5.109638e-04 -5.339453e-04
## ASV6984     -3.504717e-04 -3.663832e-04 -3.829812e-04 -4.002923e-04
## ASV0396     -2.086765e-04 -2.144182e-04 -2.201034e-04 -2.257069e-04
## ASV4297      5.056335e-04  5.270041e-04  5.491691e-04  5.721498e-04
## ASV2622      1.166073e-03  1.216294e-03  1.268455e-03  1.322613e-03
## ASV3512      1.941088e-04  2.039616e-04  2.143362e-04  2.252615e-04
## ASV2411      4.181214e-04  4.376557e-04  4.580789e-04  4.794288e-04
## ASV2291     -1.139981e-04 -1.200126e-04 -1.263651e-04 -1.330761e-04
## ASV0807      5.119673e-04  5.371901e-04  5.636625e-04  5.914449e-04
## ASV1292      2.670441e-04  2.787193e-04  2.908629e-04  3.034906e-04
## ASV1035      1.113479e-04  1.153987e-04  1.195428e-04  1.237776e-04
## ASV0070     -2.623258e-04 -2.722831e-04 -2.824976e-04 -2.929641e-04
## ASV0255      1.084458e-04  1.129215e-04  1.175452e-04  1.223180e-04
## ASV0057     -1.179415e-03 -1.228360e-03 -1.279024e-03 -1.331441e-03
## ASV0077     -1.611103e-04 -1.667216e-04 -1.724267e-04 -1.782165e-04
## ASV0625      1.189715e-03  1.240267e-03  1.292703e-03  1.347070e-03
## ASV2464      5.677041e-04  5.912110e-04  6.155455e-04  6.407251e-04
## ASV1315      1.058269e-03  1.106551e-03  1.156964e-03  1.209596e-03
## ASV2673      8.008566e-04  8.387662e-04  8.784570e-04  9.200111e-04
## ASV2161      3.347345e-04  3.508536e-04  3.677533e-04  3.854713e-04
## ASV0337     -5.120367e-04 -5.348129e-04 -5.585321e-04 -5.832273e-04
## ASV7680     -6.094377e-04 -6.371717e-04 -6.661082e-04 -6.962943e-04
## ASV0611      1.334250e-03  1.395911e-03  1.460336e-03  1.527642e-03
## ASV3118     -4.551803e-04 -4.762216e-04 -4.982033e-04 -5.211642e-04
## ASV1284      5.053345e-04  5.292696e-04  5.542874e-04  5.804297e-04
## ASV0889      3.513706e-04  3.667358e-04  3.827216e-04  3.993495e-04
## ASV4649     -3.781040e-04 -3.952330e-04 -4.130984e-04 -4.317285e-04
## ASV1108     -4.982297e-04 -5.220764e-04 -5.470631e-04 -5.732436e-04
## ASV0738     -2.621961e-05 -2.389868e-05 -2.117406e-05 -1.800490e-05
## ASV0473      6.678693e-05  6.949584e-05  7.229500e-05  7.518591e-05
## ASV0598     -5.125283e-04 -5.333433e-04 -5.548493e-04 -5.770564e-04
## ASV0429      8.642279e-04  9.024644e-04  9.422561e-04  9.836539e-04
## ASV1549      8.955336e-04  9.381552e-04  9.827960e-04  1.029550e-03
## ASV1203      6.408090e-04  6.687808e-04  6.978626e-04  7.280892e-04
## ASV4532      1.695926e-05  1.704601e-05  1.708459e-05  1.706966e-05
## ASV0274     -6.211999e-04 -6.466958e-04 -6.730768e-04 -7.003613e-04
## ASV0163     -8.964008e-04 -9.332712e-04 -9.714102e-04 -1.010841e-03
## ASV1298      3.624034e-04  3.772425e-04  3.925905e-04  4.084574e-04
## ASV9424     -8.144860e-04 -8.520362e-04 -8.912616e-04 -9.322322e-04
## ASV0412      1.216144e-03  1.269624e-03  1.325270e-03  1.383154e-03
## ASV0284      5.268708e-04  5.487533e-04  5.714104e-04  5.948587e-04
## ASV0620     -4.366497e-04 -4.579008e-04 -4.801911e-04 -5.035706e-04
## ASV0153     -8.762290e-04 -9.171377e-04 -9.599145e-04 -1.004640e-03
## ASV0498      1.270940e-04  1.351771e-04  1.437889e-04  1.529619e-04
## ASV0097      6.201230e-04  6.490146e-04  6.792341e-04  7.108413e-04
## ASV0104     -2.815122e-03 -2.940475e-03 -3.071051e-03 -3.207038e-03
## ASV1282      5.158940e-04  5.398877e-04  5.649398e-04  5.910900e-04
## ASV3883     -2.952944e-04 -3.092267e-04 -3.238017e-04 -3.390471e-04
## ASV0801      3.080401e-04  3.234039e-04  3.395446e-04  3.565010e-04
## ASV1611     -1.099295e-03 -1.149407e-03 -1.201703e-03 -1.256270e-03
## ASV0227     -4.112697e-04 -4.311731e-04 -4.520381e-04 -4.739097e-04
## ASV0833      4.478907e-04  4.697777e-04  4.927375e-04  5.168213e-04
## ASV0718      1.016385e-03  1.062145e-03  1.109853e-03  1.159582e-03
## ASV1139      3.474108e-04  3.609702e-04  3.749191e-04  3.892558e-04
## ASV0766     -2.757154e-04 -2.877693e-04 -3.003035e-04 -3.133334e-04
## ASV2091      1.301486e-03  1.355957e-03  1.412405e-03  1.470880e-03
## ASV1238     -2.552408e-05 -2.379631e-05 -2.179115e-05 -1.948622e-05
## ASV9193     -1.861772e-04 -1.973219e-04 -2.091262e-04 -2.216247e-04
## ASV0290     -1.139893e-04 -1.195025e-04 -1.252763e-04 -1.313218e-04
## ASV0231      1.068023e-03  1.115307e-03  1.164533e-03  1.215770e-03
## ASV0185      2.618118e-04  2.787820e-04  2.969186e-04  3.163021e-04
## ASV2330      3.047467e-04  3.178525e-04  3.314618e-04  3.455891e-04
## ASV3119     -3.836243e-04 -4.031010e-04 -4.235971e-04 -4.451668e-04
## ASV2368     -5.076872e-04 -5.317314e-04 -5.569060e-04 -5.832634e-04
## ASV0122     -3.717369e-04 -3.872997e-04 -4.034319e-04 -4.201482e-04
## ASV1044      7.107494e-04  7.453610e-04  7.816733e-04  8.197698e-04
## ASV0160     -9.044183e-04 -9.412774e-04 -9.793796e-04 -1.018746e-03
## ASV0326      6.215542e-04  6.496709e-04  6.789940e-04  7.095694e-04
## ASV1388      1.077391e-03  1.125322e-03  1.175239e-03  1.227212e-03
## ASV0792      1.210592e-03  1.263397e-03  1.318294e-03  1.375349e-03
## ASV0036     -7.891002e-04 -8.256164e-04 -8.637709e-04 -9.036325e-04
## ASV2125      1.256638e-03  1.312400e-03  1.370462e-03  1.430902e-03
## ASV1075      2.525160e-04  2.646732e-04  2.774219e-04  2.907914e-04
## ASV0390      2.621547e-04  2.758470e-04  2.902934e-04  3.055377e-04
## ASV3790     -1.017847e-03 -1.063956e-03 -1.112058e-03 -1.162232e-03
## ASV1535     -1.122052e-04 -1.186824e-04 -1.255488e-04 -1.328278e-04
## ASV0263      2.109108e-04  2.204112e-04  2.303128e-04  2.406302e-04
## ASV0675      1.723053e-03  1.803958e-03  1.888582e-03  1.977085e-03
## ASV3348      1.750881e-04  1.840392e-04  1.934701e-04  2.034079e-04
## ASV0058     -1.562467e-03 -1.630731e-03 -1.701727e-03 -1.775544e-03
## ASV4142      3.989786e-04  4.166109e-04  4.349592e-04  4.540470e-04
## ASV0059     -1.340793e-03 -1.398966e-03 -1.459432e-03 -1.522260e-03
## ASV0013     -2.860439e-03 -2.987918e-03 -3.120717e-03 -3.259031e-03
## ASV0033     -8.626888e-04 -9.028350e-04 -9.448027e-04 -9.886698e-04
## ASV4354     -3.649774e-04 -3.809153e-04 -3.974951e-04 -4.147390e-04
## ASV0022     -9.107501e-04 -9.530884e-04 -9.973435e-04 -1.043597e-03
## ASV0134     -2.378121e-04 -2.497204e-04 -2.622391e-04 -2.753998e-04
## ASV0415     -1.474483e-04 -1.515913e-04 -1.557108e-04 -1.597913e-04
## ASV10103    -6.233504e-04 -6.514842e-04 -6.808162e-04 -7.113911e-04
## ASV1613      9.934155e-04  1.036697e-03  1.081689e-03  1.128446e-03
## ASV0135     -2.866483e-05 -2.757332e-05 -2.621753e-05 -2.456790e-05
## ASV0469     -1.236970e-03 -1.290671e-03 -1.346487e-03 -1.404484e-03
## ASV0471      8.425147e-04  8.819621e-04  9.231859e-04  9.662577e-04
## ASV0451     -2.316817e-04 -2.432599e-04 -2.554352e-04 -2.682395e-04
## ASV0747      3.377987e-04  3.546226e-04  3.722886e-04  3.908376e-04
## ASV1314     -4.973439e-04 -5.214284e-04 -5.466892e-04 -5.731840e-04
## ASV0425     -1.376043e-03 -1.434017e-03 -1.494128e-03 -1.556429e-03
## ASV0559     -7.875084e-04 -8.208675e-04 -8.554776e-04 -8.913737e-04
## ASV0148     -8.362487e-04 -8.706797e-04 -9.063019e-04 -9.431377e-04
## ASV0129     -3.866054e-04 -4.006441e-04 -4.150046e-04 -4.296776e-04
## ASV1072      3.890372e-04  4.043626e-04  4.201711e-04  4.364691e-04
## ASV2390      2.990964e-04  3.117408e-04  3.248480e-04  3.384288e-04
## ASV0548      9.240483e-04  9.660456e-04  1.009873e-03  1.055605e-03
## ASV0168     -1.356199e-03 -1.415075e-03 -1.476277e-03 -1.539879e-03
## ASV0066     -1.030187e-03 -1.076155e-03 -1.124041e-03 -1.173913e-03
## ASV0468     -3.773443e-04 -3.941327e-04 -4.116156e-04 -4.298174e-04
## ASV0172     -1.745822e-04 -1.795586e-04 -1.845100e-04 -1.894170e-04
## ASV0236     -4.717186e-04 -4.886359e-04 -5.059160e-04 -5.235446e-04
## ASV0250      9.428707e-05  1.031251e-04  1.127212e-04  1.231342e-04
## ASV0338     -3.134438e-05 -2.995323e-05 -2.827918e-05 -2.629534e-05
## ASV0450     -8.785458e-06 -9.351253e-06 -9.956965e-06 -1.060558e-05
## ASV0377      1.130433e-03  1.181106e-03  1.233915e-03  1.288939e-03
## ASV1022      3.193706e-04  3.340216e-04  3.493231e-04  3.653025e-04
## ASV6174     -7.423495e-05 -7.732693e-05 -8.053238e-05 -8.385463e-05
## ASV0786      1.167616e-04  1.212631e-04  1.258909e-04  1.306443e-04
## ASV0053     -1.375743e-03 -1.438233e-03 -1.503425e-03 -1.571423e-03
## ASV0697     -3.782969e-04 -3.939778e-04 -4.102165e-04 -4.270257e-04
## ASV0785      1.001310e-03  1.046036e-03  1.092657e-03  1.141243e-03
## ASV1967     -6.468902e-04 -6.741743e-04 -7.024669e-04 -7.317945e-04
## ASV0385     -2.819056e-04 -2.928668e-04 -3.041689e-04 -3.158169e-04
## ASV0295      2.733250e-05  3.069041e-05  3.438127e-05  3.843427e-05
## ASV0072     -1.044575e-03 -1.088729e-03 -1.134526e-03 -1.182009e-03
## ASV0157     -4.234648e-04 -4.402019e-04 -4.574360e-04 -4.751660e-04
## ASV0501      5.303101e-04  5.559633e-04  5.828280e-04  6.109561e-04
## ASV10729    -8.423633e-04 -8.810466e-04 -9.214400e-04 -9.636134e-04
## ASV1470      3.300575e-04  3.420942e-04  3.544251e-04  3.670459e-04
## ASV0050     -2.676734e-03 -2.794454e-03 -2.916954e-03 -3.044397e-03
## ASV0411     -5.500259e-05 -5.652985e-05 -5.805493e-05 -5.957379e-05
## ASV0549      5.277664e-04  5.528675e-04  5.791715e-04  6.067372e-04
## ASV0184      3.199616e-04  3.344762e-04  3.496232e-04  3.654288e-04
## ASV0705      4.003404e-04  4.194010e-04  4.393577e-04  4.602508e-04
## ASV1715      9.654836e-04  1.009063e-03  1.054507e-03  1.101887e-03
## ASV0603      1.221676e-04  1.281945e-04  1.345286e-04  1.411866e-04
## ASV0826      3.015275e-04  3.137290e-04  3.263329e-04  3.393450e-04
## ASV0034     -1.200240e-03 -1.252014e-03 -1.305785e-03 -1.361609e-03
## ASV0838      2.693515e-04  2.816747e-04  2.945297e-04  3.079361e-04
## ASV0614     -6.911986e-04 -7.215923e-04 -7.532174e-04 -7.861155e-04
## ASV0014     -2.606357e-03 -2.721601e-03 -2.841579e-03 -2.966458e-03
## ASV0585     -1.462516e-04 -1.521386e-04 -1.582210e-04 -1.645018e-04
## ASV0016     -2.666063e-03 -2.784068e-03 -2.906932e-03 -3.034825e-03
## ASV5394     -6.898671e-04 -7.213080e-04 -7.541170e-04 -7.883477e-04
## ASV0666      5.723591e-04  5.974836e-04  6.236179e-04  6.507946e-04
## ASV2085      1.945877e-04  2.006940e-04  2.068343e-04  2.129916e-04
## ASV0003     -2.432152e-03 -2.539324e-03 -2.650869e-03 -2.766938e-03
## ASV0346     -8.624622e-06 -6.225468e-06 -3.489121e-06 -3.840506e-07
## ASV0267     -3.812800e-04 -3.971482e-04 -4.135662e-04 -4.305429e-04
## ASV0353      5.924435e-04  6.228242e-04  6.547915e-04  6.884268e-04
## ASV2419      6.792580e-04  7.086512e-04  7.391922e-04  7.709156e-04
## ASV0447      3.615252e-04  3.803777e-04  4.002479e-04  4.211911e-04
## ASV0654      1.090865e-03  1.140931e-03  1.193202e-03  1.247767e-03
## ASV0151      1.860911e-04  1.961754e-04  2.068479e-04  2.181453e-04
## ASV0065     -9.674713e-04 -1.009604e-03 -1.053414e-03 -1.098953e-03
## ASV0527      7.182894e-04  7.503763e-04  7.838066e-04  8.186290e-04
## ASV4055     -2.882264e-04 -3.024551e-04 -3.174051e-04 -3.331146e-04
## ASV0166     -7.601368e-04 -7.907384e-04 -8.223542e-04 -8.550015e-04
## ASV0417     -6.859316e-04 -7.157336e-04 -7.467091e-04 -7.788944e-04
## ASV0078     -5.261918e-04 -5.477780e-04 -5.701064e-04 -5.931908e-04
## ASV0322     -6.242139e-04 -6.492786e-04 -6.751741e-04 -7.019149e-04
## ASV0156     -8.283758e-04 -8.627497e-04 -8.983623e-04 -9.352446e-04
## ASV0648     -8.187197e-04 -8.567231e-04 -8.964436e-04 -9.379545e-04
## ASV0407      5.620683e-05  5.902323e-05  6.200101e-05  6.515150e-05
## ASV2030     -1.607963e-04 -1.671982e-04 -1.738116e-04 -1.806409e-04
## ASV0300      5.149628e-04  5.407827e-04  5.679098e-04  5.964089e-04
## ASV1150     -5.459401e-05 -5.642059e-05 -5.826827e-05 -6.013300e-05
## ASV0958      5.129645e-04  5.380264e-04  5.643336e-04  5.919491e-04
## ASV0216     -8.177194e-04 -8.524038e-04 -8.883869e-04 -9.257040e-04
## ASV0446      1.226134e-03  1.284664e-03  1.345956e-03  1.410132e-03
## ASV0367     -4.033025e-04 -4.213854e-04 -4.402339e-04 -4.598771e-04
## ASV0200     -7.347049e-04 -7.672150e-04 -8.010716e-04 -8.363238e-04
## ASV0334     -3.407254e-04 -3.525547e-04 -3.645875e-04 -3.768075e-04
## ASV1311      5.291568e-04  5.526824e-04  5.771827e-04  6.026924e-04
## ASV0458      5.603294e-04  5.848415e-04  6.103367e-04  6.368475e-04
## ASV1371      1.837024e-05  1.928599e-05  2.024732e-05  2.125628e-05
## ASV0418      6.484905e-04  6.756575e-04  7.038207e-04  7.330058e-04
## ASV0004      8.093523e-04  8.447624e-04  8.815890e-04  9.198779e-04
## ASV1943      5.865938e-04  6.117491e-04  6.378741e-04  6.649980e-04
## ASV1495     -1.872031e-04 -1.980633e-04 -2.095965e-04 -2.218455e-04
## ASV0901     -9.626136e-04 -1.007419e-03 -1.054264e-03 -1.103237e-03
## ASV0628      5.397944e-04  5.630232e-04  5.871402e-04  6.121697e-04
## ASV0400      2.279104e-04  2.381651e-04  2.488447e-04  2.599632e-04
## ASV0116     -7.262151e-04 -7.597017e-04 -7.946850e-04 -8.312275e-04
## ASV0788      5.969573e-04  6.237435e-04  6.516608e-04  6.807511e-04
## ASV0117      4.001020e-04  4.194410e-04  4.397235e-04  4.609958e-04
## ASV3137      1.099793e-04  1.150775e-04  1.204088e-04  1.259836e-04
## ASV0001      9.572293e-04  9.977311e-04  1.039745e-03  1.083311e-03
## ASV1651      6.211364e-04  6.466020e-04  6.729449e-04  7.001822e-04
## ASV1692      7.259281e-04  7.601264e-04  7.959117e-04  8.333549e-04
## ASV0660      3.848377e-04  4.002059e-04  4.160393e-04  4.323371e-04
## ASV0508      3.661509e-05  3.742233e-05  3.819756e-05  3.893493e-05
## ASV1660     -3.058046e-04 -3.206789e-04 -3.362767e-04 -3.526321e-04
## ASV0233      1.589698e-04  1.663484e-04  1.740668e-04  1.821407e-04
## ASV1343     -7.225878e-04 -7.557615e-04 -7.904043e-04 -8.265769e-04
## ASV0209      6.446565e-04  6.721587e-04  7.007044e-04  7.303232e-04
## ASV0193     -7.899495e-04 -8.220948e-04 -8.553433e-04 -8.897180e-04
## ASV0357     -4.286737e-05 -4.374414e-05 -4.456309e-05 -4.531362e-05
## ASV0198      2.001620e-04  2.098647e-04  2.200313e-04  2.306825e-04
## ASV0007      9.074155e-04  9.458170e-04  9.856535e-04  1.026964e-03
## ASV1772     -8.865534e-05 -9.216485e-05 -9.577547e-05 -9.948606e-05
## ASV0009      8.541120e-04  8.901163e-04  9.274539e-04  9.661600e-04
## ASV0006      3.319762e-04  3.448767e-04  3.581607e-04  3.718302e-04
## ASV0011     -1.010329e-03 -1.056808e-03 -1.105344e-03 -1.156019e-03
## ASV0015      6.799354e-04  7.096800e-04  7.406115e-04  7.727675e-04
## ASV0017      7.186257e-04  7.499684e-04  7.825555e-04  8.164262e-04
## ASV0235     -5.977361e-04 -6.254394e-04 -6.543774e-04 -6.845997e-04
## ASV0382      1.429220e-04  1.518407e-04  1.613330e-04  1.714340e-04
## ASV2357      8.929266e-04  9.336771e-04  9.762115e-04  1.020602e-03
## ASV0567     -6.236041e-04 -6.506390e-04 -6.787483e-04 -7.079678e-04
## ASV0165      7.183360e-04  7.512418e-04  7.855934e-04  8.214489e-04
## ASV0005      1.387945e-03  1.448538e-03  1.511550e-03  1.577060e-03
## ASV0384     -4.424541e-05 -4.452849e-05 -4.466525e-05 -4.463560e-05
## ASV0002      3.035882e-04  3.176829e-04  3.324121e-04  3.478023e-04
## ASV3017      8.057261e-04  8.404902e-04  8.766058e-04  9.141138e-04
## ASV0091      3.257337e-04  3.410237e-04  3.570185e-04  3.737494e-04
## ASV0186     -8.563828e-04 -8.952904e-04 -9.358793e-04 -9.782143e-04
## ASV0370      1.044519e-04  1.101411e-04  1.161617e-04  1.225342e-04
## ASV0018      1.448849e-03  1.512367e-03  1.578446e-03  1.647171e-03
## ASV1377      1.264999e-03  1.320120e-03  1.377419e-03  1.436964e-03
## ASV0019      1.451633e-03  1.515325e-03  1.581590e-03  1.650512e-03
## ASV0023      7.894690e-05  8.059670e-05  8.216320e-05  8.363182e-05
## ASV2194      4.585341e-04  4.787778e-04  4.998692e-04  5.218412e-04
## ASV1155     -4.445232e-05 -4.553667e-05 -4.658470e-05 -4.758785e-05
## ASV0510     -4.911189e-04 -5.100608e-04 -5.295598e-04 -5.496195e-04
## ASV2371     -4.962864e-04 -5.162645e-04 -5.368967e-04 -5.581925e-04
## ASV0024      7.853903e-06  6.292680e-06  4.510640e-06  2.487958e-06
## ASV2452      6.647850e-04  6.927320e-04  7.217006e-04  7.517159e-04
## ASV2332      3.948549e-05  4.260118e-05  4.597737e-05  4.963542e-05
## ASV2591      6.354517e-05  6.864707e-05  7.414788e-05  8.007610e-05
## ASV0521      9.791404e-04  1.025231e-03  1.073448e-03  1.123885e-03
## ASV5542      3.098634e-04  3.249016e-04  3.406630e-04  3.571806e-04
## ASV0336     -4.016312e-04 -4.180018e-04 -4.349453e-04 -4.524758e-04
## ASV10102     6.744864e-04  7.058861e-04  7.387080e-04  7.730123e-04
## ASV16823    -4.831352e-04 -5.026029e-04 -5.227131e-04 -5.434763e-04
## ASV3104      4.830483e-04  5.025090e-04  5.226117e-04  5.433668e-04
## ASV0781      2.560016e-04  2.676625e-04  2.798296e-04  2.925226e-04
## ASV10899     2.679582e-04  2.820387e-04  2.968873e-04  3.125463e-04
## ASV11222    -4.829998e-04 -5.024573e-04 -5.225567e-04 -5.433083e-04
## ASV11327    -4.829129e-04 -5.023634e-04 -5.224553e-04 -5.431989e-04
## ASV12458    -4.828261e-04 -5.022696e-04 -5.223540e-04 -5.430895e-04
## ASV1636     -3.950503e-04 -4.109086e-04 -4.272827e-04 -4.441799e-04
## ASV1890     -4.875246e-04 -5.076558e-04 -5.284993e-04 -5.500719e-04
## ASV2898      1.094082e-03  1.141813e-03  1.191439e-03  1.243017e-03
## ASV8328     -4.696801e-05 -4.634516e-05 -4.546571e-05 -4.430174e-05
## ASV0709     -8.994093e-04 -9.389728e-04 -9.801328e-04 -1.022942e-03
## ASV0856      1.597598e-04  1.679354e-04  1.765422e-04  1.856033e-04
## ASV0909     -3.423812e-04 -3.547136e-04 -3.673095e-04 -3.801581e-04
## ASV0937     -7.062961e-04 -7.380965e-04 -7.712580e-04 -8.058336e-04
## ASV11390    -4.826496e-04 -5.020795e-04 -5.221494e-04 -5.428695e-04
## ASV11966     2.830089e-04  2.971121e-04  3.119266e-04  3.274874e-04
## ASV12990     1.501042e-04  1.573005e-04  1.648324e-04  1.727137e-04
## ASV14797     5.261292e-04  5.488790e-04  5.725109e-04  5.970504e-04
## ASV14904    -4.826385e-04 -5.020684e-04 -5.221384e-04 -5.428588e-04
## ASV15304     1.635276e-04  1.725554e-04  1.821029e-04  1.921999e-04
## ASV16696    -4.825746e-04 -5.019999e-04 -5.220651e-04 -5.427805e-04
## ASV1690      2.908030e-04  3.055346e-04  3.210214e-04  3.373006e-04
## ASV2029      1.407776e-03  1.469647e-03  1.534016e-03  1.600965e-03
## ASV2834      7.648617e-04  7.993027e-04  8.352104e-04  8.726402e-04
## ASV4003      2.530067e-04  2.667850e-04  2.813505e-04  2.967490e-04
## ASV4064      5.303034e-04  5.542178e-04  5.791475e-04  6.051299e-04
## ASV4294      2.179842e-04  2.299690e-04  2.426523e-04  2.560764e-04
## ASV4609     -1.440879e-05 -1.453461e-05 -1.462399e-05 -1.467246e-05
## ASV6283     -4.825942e-04 -5.020236e-04 -5.220935e-04 -5.428144e-04
## ASV6491     -4.825074e-04 -5.019299e-04 -5.219923e-04 -5.427051e-04
## ASV7453      2.308872e-04  2.431249e-04  2.560333e-04  2.696490e-04
## ASV7959      6.728490e-05  7.216824e-05  7.740964e-05  8.303373e-05
## ASV8219      4.824623e-04  5.018823e-04  5.219423e-04  5.426527e-04
## ASV8547     -4.823756e-04 -5.017886e-04 -5.218411e-04 -5.425435e-04
## ASV9319      3.651204e-04  3.825099e-04  4.007163e-04  4.197760e-04
## ASV9382     -4.823307e-04 -5.017406e-04 -5.217900e-04 -5.424891e-04
## ASV11516    -4.822440e-04 -5.016470e-04 -5.216889e-04 -5.423799e-04
## ASV14377    -4.821574e-04 -5.015534e-04 -5.215878e-04 -5.422708e-04
## ASV1867      7.685797e-04  8.040192e-04  8.410384e-04  8.797026e-04
## ASV1895     -1.612549e-04 -1.675739e-04 -1.740904e-04 -1.808073e-04
## ASV3168      3.205586e-04  3.345733e-04  3.491371e-04  3.642653e-04
## ASV4449      6.136757e-04  6.393516e-04  6.659648e-04  6.935394e-04
## ASV6596      4.007742e-04  4.210039e-04  4.422862e-04  4.646773e-04
## ASV7492     -1.577217e-04 -1.624229e-04 -1.671290e-04 -1.718255e-04
## ASV9854     -2.389483e-04 -2.479996e-04 -2.573014e-04 -2.668535e-04
## ASV6296      4.819955e-04  5.013799e-04  5.214021e-04  5.420724e-04
## ASV4201      2.085049e-04  2.206256e-04  2.334902e-04  2.471446e-04
## ASV0552      1.298209e-03  1.358554e-03  1.421621e-03  1.487525e-03
## ASV3671     -7.662370e-05 -7.816171e-05 -7.961254e-05 -8.096196e-05
## ASV3529     -7.969302e-05 -8.099668e-05 -8.217357e-05 -8.320582e-05
## ASV1060      3.193848e-04  3.339978e-04  3.492549e-04  3.651826e-04
## ASV0239     -6.840031e-04 -7.120104e-04 -7.409619e-04 -7.708721e-04
## ASV5711     -6.334697e-04 -6.599820e-04 -6.874620e-04 -7.159349e-04
## ASV4152     -8.468029e-04 -8.831485e-04 -9.208944e-04 -9.600822e-04
## ASV1461      7.556593e-04  7.875069e-04  8.205175e-04  8.547187e-04
## ASV2877      6.226762e-04  6.497104e-04  6.778013e-04  7.069801e-04
## ASV0012      4.830578e-04  5.054654e-04  5.288786e-04  5.533392e-04
## ASV9823      1.197558e-04  1.229833e-04  1.262020e-04  1.294039e-04
## ASV0008      5.239948e-04  5.480289e-04  5.731206e-04  5.993124e-04
## ASV7832     -5.227406e-04 -5.451334e-04 -5.683905e-04 -5.925385e-04
## ASV1915      5.997869e-05  6.375990e-05  6.778512e-05  7.206904e-05
## ASV0055      3.599498e-04  3.754909e-04  3.916282e-04  4.083778e-04
## ASV0032      8.860886e-04  9.247644e-04  9.649841e-04  1.006798e-03
## ASV2977     -7.077659e-04 -7.378632e-04 -7.690932e-04 -8.014870e-04
## ASV0466      7.074934e-04  7.367318e-04  7.669922e-04  7.982951e-04
## ASV3866      7.956892e-04  8.320552e-04  8.700120e-04  9.096226e-04
## ASV0040      1.053521e-03  1.101742e-03  1.152076e-03  1.204608e-03
## ASV0496     -8.933370e-05 -9.561664e-05 -1.023639e-04 -1.096095e-04
## ASV0052      1.267085e-03  1.323226e-03  1.381675e-03  1.442511e-03
## ASV3828     -7.664091e-04 -7.996174e-04 -8.341419e-04 -8.700263e-04
## ASV1930      4.997443e-04  5.225882e-04  5.464223e-04  5.712837e-04
## ASV2126      7.891043e-04  8.240390e-04  8.604041e-04  8.982485e-04
## ASV0793      4.937222e-04  5.173493e-04  5.420952e-04  5.680104e-04
## ASV0299     -3.160979e-04 -3.286500e-04 -3.415946e-04 -3.549356e-04
## ASV0208      7.801652e-04  8.174822e-04  8.565696e-04  8.975086e-04
## ASV0511     -3.782041e-04 -3.929700e-04 -4.081691e-04 -4.238017e-04
## ASV1123     -5.032928e-04 -5.237729e-04 -5.449418e-04 -5.668113e-04
## ASV0099     -2.668023e-04 -2.774668e-04 -2.884686e-04 -2.998105e-04
## ASV0752     -8.056131e-05 -8.544044e-05 -9.062952e-05 -9.614797e-05
## ASV0883      1.586350e-05  1.715674e-05  1.855215e-05  2.005713e-05
## ASV0683      6.849151e-04  7.172087e-04  7.509997e-04  7.863543e-04
## ASV4117     -7.655754e-04 -7.984727e-04 -8.326435e-04 -8.681266e-04
## ASV2172      2.968733e-04  3.103325e-04  3.243704e-04  3.390091e-04
## ASV0330     -5.222245e-04 -5.453644e-04 -5.694674e-04 -5.945692e-04
## ASV0728      5.161366e-04  5.401084e-04  5.651533e-04  5.913149e-04
## ASV0499      1.035098e-03  1.084081e-03  1.135365e-03  1.189054e-03
## ASV0120     -1.108173e-03 -1.157603e-03 -1.209085e-03 -1.262690e-03
## ASV1446      6.847614e-05  6.986947e-05  7.117747e-05  7.238507e-05
## ASV17171    -7.315569e-04 -7.632851e-04 -7.962677e-04 -8.305453e-04
## ASV0533      2.259104e-04  2.369591e-04  2.485556e-04  2.607269e-04
## ASV2495     -3.110096e-04 -3.256041e-04 -3.408842e-04 -3.568828e-04
## ASV5582      2.443696e-04  2.538786e-04  2.636644e-04  2.737270e-04
## ASV1488      3.021833e-04  3.180847e-04  3.348109e-04  3.524001e-04
## ASV0682      7.292831e-04  7.641566e-04  8.006978e-04  8.389859e-04
## ASV0068     -4.940464e-05 -5.249950e-05 -5.579258e-05 -5.929568e-05
## ASV1987     -4.093233e-04 -4.299076e-04 -4.515527e-04 -4.743138e-04
## ASV0035      1.100262e-04  1.129114e-04  1.157322e-04  1.184698e-04
## ASV7192     -4.782865e-04 -4.979147e-04 -5.182172e-04 -5.392066e-04
## ASV0873      5.728531e-05  5.860187e-05  5.987524e-05  6.109689e-05
## ASV4749      1.571898e-05  1.419591e-05  1.241003e-05  1.033437e-05
## ASV2174      4.141200e-04  4.296114e-04  4.455411e-04  4.619133e-04
## ASV1476     -4.074151e-04 -4.254110e-04 -4.441532e-04 -4.636698e-04
## ASV0740     -1.037225e-03 -1.085592e-03 -1.136158e-03 -1.189018e-03
## ASV0170      2.121953e-04  2.216025e-04  2.314014e-04  2.416065e-04
## ASV2466     -9.130794e-04 -9.536432e-04 -9.958973e-04 -1.039904e-03
## ASV1709      6.956656e-04  7.257154e-04  7.569377e-04  7.893685e-04
## ASV6170     -5.424621e-04 -5.630964e-04 -5.843662e-04 -6.062841e-04
## ASV3673      6.835362e-04  7.121575e-04  7.418616e-04  7.726829e-04
## ASV1745      1.547545e-05  1.482831e-05  1.407291e-05  1.320201e-05
## ASV0380     -4.095692e-04 -4.238144e-04 -4.383880e-04 -4.532878e-04
## ASV0426     -1.312925e-04 -1.358822e-04 -1.405685e-04 -1.453479e-04
## ASV0202     -1.096770e-04 -1.111444e-04 -1.123748e-04 -1.133345e-04
## ASV6350     -5.403818e-04 -5.609948e-04 -5.822497e-04 -6.041602e-04
## ASV0713     -4.453009e-04 -4.654846e-04 -4.865425e-04 -5.085090e-04
## ASV1822      1.141248e-04  1.204974e-04  1.272277e-04  1.343344e-04
## ASV4569      6.820377e-04  7.113832e-04  7.418905e-04  7.735993e-04
## ASV0030     -1.769314e-04 -1.859044e-04 -1.953232e-04 -2.052070e-04
## ASV0331      3.123854e-04  3.281014e-04  3.446285e-04  3.620094e-04
## ASV2981      7.434421e-04  7.784411e-04  8.150370e-04  8.532966e-04
## ASV0828     -5.037787e-04 -5.281284e-04 -5.536458e-04 -5.803846e-04
## ASV2440      1.155606e-03  1.209449e-03  1.265729e-03  1.324547e-03
## ASV3006     -4.183829e-04 -4.331468e-04 -4.482742e-04 -4.637656e-04
## ASV3875     -4.183196e-04 -4.330791e-04 -4.482020e-04 -4.636886e-04
## ASV4511      2.937119e-04  3.078702e-04  3.227134e-04  3.382743e-04
## ASV4700     -4.182570e-04 -4.330122e-04 -4.481306e-04 -4.636124e-04
## ASV5804     -4.181937e-04 -4.329447e-04 -4.480584e-04 -4.635354e-04
## ASV6826      5.389666e-04  5.645468e-04  5.913277e-04  6.193639e-04
## ASV7280      4.832287e-04  5.071228e-04  5.321784e-04  5.584473e-04
## ASV7535     -4.181788e-04 -4.329299e-04 -4.480440e-04 -4.635215e-04
## ASV0651     -4.864942e-04 -5.066382e-04 -5.274774e-04 -5.490237e-04
## ASV0913      6.961675e-04  7.287022e-04  7.627298e-04  7.983164e-04
## ASV10832    -4.181196e-04 -4.328667e-04 -4.479766e-04 -4.634497e-04
## ASV1117     -9.459525e-04 -9.868055e-04 -1.029276e-03 -1.073418e-03
## ASV11329     2.942363e-04  3.110379e-04  3.288261e-04  3.476573e-04
## ASV13209     2.888616e-05  3.333102e-05  3.816389e-05  4.340840e-05
## ASV1345      1.583261e-04  1.669180e-04  1.759566e-04  1.854603e-04
## ASV1719     -4.180409e-04 -4.327840e-04 -4.478897e-04 -4.633587e-04
## ASV1886      5.342621e-04  5.571092e-04  5.808625e-04  6.055549e-04
## ASV2158     -6.702596e-05 -6.671721e-05 -6.618648e-05 -6.541609e-05
## ASV2189      5.935815e-04  6.200608e-04  6.476561e-04  6.764092e-04
## ASV2257      4.313004e-04  4.500341e-04  4.695379e-04  4.898421e-04
## ASV2283      4.178965e-04  4.326291e-04  4.477237e-04  4.631808e-04
## ASV2328      4.178333e-04  4.325616e-04  4.476516e-04  4.631039e-04
## ASV2434     -6.817214e-04 -7.100206e-04 -7.393851e-04 -7.698505e-04
## ASV2648      4.176801e-04  4.323967e-04  4.474742e-04  4.629132e-04
## ASV2698      7.063179e-04  7.385277e-04  7.721577e-04  8.072668e-04
## ASV2775      7.918245e-04  8.238259e-04  8.569160e-04  8.911176e-04
## ASV3171      4.175335e-04  4.322389e-04  4.473047e-04  4.627311e-04
## ASV3227      5.823029e-04  6.054234e-04  6.292914e-04  6.539188e-04
## ASV3397      7.111388e-05  7.546669e-05  8.006352e-05  8.491416e-05
## ASV3444      6.486226e-04  6.748854e-04  7.020882e-04  7.302595e-04
## ASV3556      4.173563e-04  4.320485e-04  4.471002e-04  4.625117e-04
## ASV3606     -4.172933e-04 -4.319812e-04 -4.470284e-04 -4.624350e-04
## ASV4190      6.228380e-04  6.511635e-04  6.807380e-04  7.116143e-04
## ASV4197      6.729057e-04  7.002006e-04  7.284528e-04  7.576870e-04
## ASV4722      6.344656e-04  6.622393e-04  6.911461e-04  7.212262e-04
## ASV4765      1.856733e-04  1.948664e-04  2.044811e-04  2.145318e-04
## ASV4809      4.171189e-04  4.317936e-04  4.468265e-04  4.622180e-04
## ASV4846      4.696410e-04  4.912105e-04  5.137164e-04  5.371935e-04
## ASV4903     -6.788467e-05 -6.766508e-05 -6.722931e-05 -6.655973e-05
## ASV4944     -4.170720e-04 -4.317445e-04 -4.467753e-04 -4.621648e-04
## ASV5151     -2.429663e-04 -2.571690e-04 -2.722138e-04 -2.881477e-04
## ASV5413     -4.170412e-04 -4.317128e-04 -4.467428e-04 -4.621315e-04
## ASV5537     -4.169783e-04 -4.316456e-04 -4.466710e-04 -4.620549e-04
## ASV5688      4.169155e-04  4.315784e-04  4.465993e-04  4.619784e-04
## ASV5752      2.737056e-04  2.877628e-04  3.025189e-04  3.180033e-04
## ASV6122     -4.168803e-04 -4.315415e-04 -4.465607e-04 -4.619381e-04
## ASV6135      4.168174e-04  4.314744e-04  4.464890e-04  4.618617e-04
## ASV6188     -4.167546e-04 -4.314072e-04 -4.464173e-04 -4.617852e-04
## ASV6216      6.709507e-04  6.981330e-04  7.262704e-04  7.553881e-04
## ASV6242      4.166088e-04  4.312506e-04  4.462491e-04  4.616047e-04
## ASV6383      4.165461e-04  4.311835e-04  4.461775e-04  4.615283e-04
## ASV6781      4.164833e-04  4.311165e-04  4.461059e-04  4.614519e-04
## ASV6799     -4.164206e-04 -4.310495e-04 -4.460344e-04 -4.613756e-04
## ASV7374     -4.163579e-04 -4.309825e-04 -4.459629e-04 -4.612993e-04
## ASV7539     -4.162952e-04 -4.309155e-04 -4.458913e-04 -4.612230e-04
## ASV8591     -4.162325e-04 -4.308485e-04 -4.458199e-04 -4.611468e-04
## ASV8637      4.161698e-04  4.307815e-04  4.457484e-04  4.610706e-04
## ASV12796    -4.161072e-04 -4.307146e-04 -4.456769e-04 -4.609944e-04
## ASV1934      5.655665e-04  5.913206e-04  6.181976e-04  6.462420e-04
## ASV22549     8.733933e-05  9.443457e-05  1.020380e-04  1.101792e-04
## ASV29857    -4.160601e-04 -4.306652e-04 -4.456253e-04 -4.609404e-04
## ASV3215      7.021399e-04  7.351678e-04  7.697348e-04  8.059112e-04
## ASV3236     -4.159916e-04 -4.305919e-04 -4.455468e-04 -4.608565e-04
## ASV3954     -4.159290e-04 -4.305250e-04 -4.454754e-04 -4.607804e-04
## ASV4850      4.158664e-04  4.304582e-04  4.454041e-04  4.607043e-04
## ASV5225      4.158038e-04  4.303913e-04  4.453327e-04  4.606282e-04
## ASV5532     -4.157413e-04 -4.303245e-04 -4.452614e-04 -4.605521e-04
## ASV7258      1.237103e-04  1.333788e-04  1.437559e-04  1.548874e-04
## ASV9474     -2.041844e-04 -2.092758e-04 -2.143148e-04 -2.192858e-04
## ASV11857    -4.156850e-04 -4.302665e-04 -4.452018e-04 -4.604912e-04
## ASV1202     -4.156225e-04 -4.301997e-04 -4.451305e-04 -4.604152e-04
## ASV14742     3.874942e-04  4.076657e-04  4.289054e-04  4.512689e-04
## ASV16652     2.031771e-04  2.134393e-04  2.241838e-04  2.354273e-04
## ASV2019      6.751020e-04  7.031144e-04  7.321583e-04  7.622635e-04
## ASV2410     -6.575529e-04 -6.868675e-04 -7.174347e-04 -7.493054e-04
## ASV2718      7.382700e-04  7.734852e-04  8.103399e-04  8.489045e-04
## ASV2738      7.486628e-04  7.785949e-04  8.095190e-04  8.414538e-04
## ASV2876      4.154862e-04  4.300543e-04  4.449755e-04  4.602501e-04
## ASV3177      4.154237e-04  4.299875e-04  4.449043e-04  4.601742e-04
## ASV4367      4.153613e-04  4.299208e-04  4.448331e-04  4.600982e-04
## ASV4635      2.246367e-04  2.380879e-04  2.523289e-04  2.674001e-04
## ASV4896      1.076213e-04  1.167594e-04  1.266006e-04  1.371924e-04
## ASV4907      4.152092e-04  4.373371e-04  4.606557e-04  4.852260e-04
## ASV5230     -4.154176e-04 -4.299855e-04 -4.449071e-04 -4.601827e-04
## ASV6509     -4.153551e-04 -4.299188e-04 -4.448359e-04 -4.601067e-04
## ASV7376     -4.152927e-04 -4.298521e-04 -4.447647e-04 -4.600308e-04
## ASV8163     -4.152303e-04 -4.297854e-04 -4.446935e-04 -4.599549e-04
## ASV8195     -4.151678e-04 -4.297187e-04 -4.446223e-04 -4.598790e-04
## ASV8923      3.331752e-04  3.501478e-04  3.679734e-04  3.866911e-04
## ASV9666     -3.581449e-04 -3.700290e-04 -3.821430e-04 -3.944816e-04
## ASV1482      4.676085e-04  4.897597e-04  5.129314e-04  5.371665e-04
## ASV2726      6.108964e-04  6.401165e-04  6.706995e-04  7.027039e-04
## ASV3281     -4.151290e-04 -4.296793e-04 -4.445825e-04 -4.598390e-04
## ASV4235     -4.150666e-04 -4.296126e-04 -4.445114e-04 -4.597632e-04
## ASV4808      6.820214e-04  7.102304e-04  7.394846e-04  7.698163e-04
## ASV4861     -6.798446e-04 -7.080167e-04 -7.372476e-04 -7.675729e-04
## ASV5276      6.721323e-04  6.996976e-04  7.282549e-04  7.578316e-04
## ASV5837      6.200572e-04  6.487651e-04  6.787795e-04  7.101583e-04
## ASV7098      6.297264e-04  6.586265e-04  6.888216e-04  7.203677e-04
## ASV8451     -4.147257e-04 -4.292445e-04 -4.441140e-04 -4.593345e-04
## ASV8694     -4.146634e-04 -4.291780e-04 -4.440430e-04 -4.592588e-04
## ASV0905     -2.694955e-04 -2.817386e-04 -2.944655e-04 -3.076867e-04
## ASV2900      5.292951e-04  5.492525e-04  5.698131e-04  5.909883e-04
## ASV3963     -4.007021e-04 -4.145614e-04 -4.287412e-04 -4.432401e-04
## ASV0041     -5.640242e-04 -5.911042e-04 -6.194587e-04 -6.491430e-04
## ASV1865      5.916736e-04  6.215523e-04  6.529400e-04  6.859090e-04
## ASV1140      4.675182e-04  4.897958e-04  5.130778e-04  5.374016e-04
## ASV1179      6.517753e-04  6.820262e-04  7.136280e-04  7.466348e-04
## ASV0279      8.754660e-04  9.136139e-04  9.533134e-04  9.946210e-04
## ASV0043     -1.102256e-04 -1.176071e-04 -1.255208e-04 -1.340060e-04
## ASV2097     -4.651368e-04 -4.840972e-04 -5.037515e-04 -5.241223e-04
## ASV0309     -2.318122e-04 -2.409380e-04 -2.503538e-04 -2.600639e-04
## ASV0607      1.109991e-03  1.161392e-03  1.215096e-03  1.271199e-03
## ASV0025     -1.182098e-03 -1.237236e-03 -1.294858e-03 -1.355067e-03
## ASV2284     -1.401505e-04 -1.436149e-04 -1.470316e-04 -1.503882e-04
## ASV0556      2.275195e-04  2.398517e-04  2.528670e-04  2.666015e-04
## ASV5040      3.344958e-04  3.453014e-04  3.562898e-04  3.674540e-04
## ASV2924     -3.654379e-04 -3.777917e-04 -3.904087e-04 -4.032861e-04
## ASV1331      1.391693e-03  1.453894e-03  1.518728e-03  1.586295e-03
## ASV0506     -5.922919e-04 -6.157641e-04 -6.399864e-04 -6.649694e-04
## ASV1514      1.049244e-03  1.096260e-03  1.145243e-03  1.196265e-03
## ASV2144      8.740178e-04  9.127673e-04  9.531313e-04  9.951697e-04
## ASV2265      1.171023e-03  1.223572e-03  1.278342e-03  1.335418e-03
## ASV5156      2.133990e-04  2.204330e-04  2.275902e-04  2.348656e-04
## ASV5534      1.586452e-04  1.627892e-04  1.668989e-04  1.709607e-04
## ASV5747     -8.734856e-05 -9.444440e-05 -1.020602e-04 -1.102275e-04
## ASV6657      5.023782e-04  5.232029e-04  5.447892e-04  5.671589e-04
## ASV0658     -5.531415e-04 -5.750726e-04 -5.977109e-04 -6.210675e-04
## ASV0716      1.426621e-04  1.484577e-04  1.544497e-04  1.606418e-04
## ASV1657      2.116905e-04  2.183417e-04  2.250728e-04  2.318750e-04
## ASV1885     -5.878136e-05 -6.435595e-05 -7.037009e-05 -7.685161e-05
## ASV2333      1.259176e-03  1.313725e-03  1.370431e-03  1.429365e-03
## ASV3375      4.399624e-04  4.573401e-04  4.752915e-04  4.938296e-04
## ASV4317      5.020166e-04  5.248973e-04  5.488005e-04  5.737717e-04
## ASV9599     -8.761782e-05 -9.473392e-05 -1.023713e-04 -1.105617e-04
## ASV0175     -1.689726e-03 -1.762388e-03 -1.837842e-03 -1.916167e-03
## ASV1032      4.712672e-04  4.896758e-04  5.086644e-04  5.282421e-04
## ASV1235     -1.707958e-05 -1.996097e-05 -2.311466e-05 -2.655947e-05
## ASV1262      1.500052e-03  1.565636e-03  1.633852e-03  1.704787e-03
## ASV1320      4.141313e-04  4.355903e-04  4.581845e-04  4.819727e-04
## ASV13797     5.392042e-04  5.619376e-04  5.855397e-04  6.100391e-04
## ASV1491      3.331255e-04  3.507846e-04  3.693724e-04  3.889327e-04
## ASV15014    -8.769585e-05 -9.481526e-05 -1.024558e-04 -1.106492e-04
## ASV1510      4.943829e-04  5.185440e-04  5.438521e-04  5.703553e-04
## ASV1551     -1.809577e-04 -1.885368e-04 -1.963936e-04 -2.045353e-04
## ASV1919      1.919375e-05  2.322968e-05  2.765696e-05  3.250260e-05
## ASV2114      2.488929e-04  2.583624e-04  2.681366e-04  2.782247e-04
## ASV21486    -8.760099e-05 -9.470884e-05 -1.023366e-04 -1.105156e-04
## ASV2448      7.467197e-04  7.780417e-04  8.105277e-04  8.442107e-04
## ASV2589      3.415838e-04  3.550362e-04  3.689297e-04  3.832736e-04
## ASV2608      6.023240e-04  6.281792e-04  6.550521e-04  6.829769e-04
## ASV2786      4.887642e-04  5.103311e-04  5.328107e-04  5.562410e-04
## ASV2827      6.365716e-04  6.640932e-04  6.927016e-04  7.224321e-04
## ASV2872      4.890258e-04  5.081134e-04  5.277884e-04  5.480572e-04
## ASV3125      5.903242e-04  6.142196e-04  6.389399e-04  6.645047e-04
## ASV3247      6.474877e-04  6.739533e-04  7.013432e-04  7.296792e-04
## ASV3451     -8.803528e-05 -9.517896e-05 -1.028453e-04 -1.110659e-04
## ASV3465     -1.264399e-04 -1.352079e-04 -1.445686e-04 -1.545575e-04
## ASV3809      3.603407e-04  3.741268e-04  3.883205e-04  4.029257e-04
## ASV4006      8.054337e-04  8.381415e-04  8.719641e-04  9.069240e-04
## ASV4046      5.676836e-04  5.905685e-04  6.142343e-04  6.386986e-04
## ASV4938     -9.207698e-05 -9.940943e-05 -1.072729e-04 -1.156993e-04
## ASV5435     -8.811661e-05 -9.526316e-05 -1.029321e-04 -1.111550e-04
## ASV5605      2.076009e-04  2.141131e-04  2.207013e-04  2.273564e-04
## ASV5635     -8.811101e-05 -9.525525e-05 -1.029215e-04 -1.111412e-04
## ASV5743      7.359029e-04  7.669219e-04  7.991162e-04  8.325222e-04
## ASV6627     -8.817285e-05 -9.532129e-05 -1.029919e-04 -1.112164e-04
## ASV6785     -8.814181e-05 -9.528640e-05 -1.029527e-04 -1.111724e-04
## ASV7368      8.317715e-04  8.691053e-04  9.080413e-04  9.486436e-04
## ASV9118      1.980654e-04  2.045905e-04  2.112359e-04  2.179986e-04
## ASV9135      1.395806e-04  1.429408e-04  1.462418e-04  1.494700e-04
## ASV9435      3.534004e-04  3.657900e-04  3.784413e-04  3.913467e-04
## ASV9671     -8.824714e-05 -9.539821e-05 -1.030713e-04 -1.112979e-04
## ASV0387     -7.993853e-04 -8.317339e-04 -8.651751e-04 -8.997299e-04
## ASV0454     -8.054822e-04 -8.388088e-04 -8.733167e-04 -9.090329e-04
## ASV0751     -5.130741e-04 -5.333365e-04 -5.542421e-04 -5.757996e-04
## ASV1081      2.280704e-04  2.382717e-04  2.488897e-04  2.599377e-04
## ASV1332      4.481949e-04  4.672769e-04  4.870750e-04  5.076083e-04
## ASV2659      7.392148e-04  7.724256e-04  8.070110e-04  8.430162e-04
## ASV2979      7.174414e-04  7.460789e-04  7.756482e-04  8.061638e-04
## ASV4184      2.586921e-04  2.665659e-04  2.744970e-04  2.824699e-04
## ASV6198      2.494606e-04  2.594098e-04  2.697072e-04  2.803635e-04
## ASV7454      4.666885e-04  4.853395e-04  5.046008e-04  5.244828e-04
## ASV8198      1.514318e-04  1.547894e-04  1.580411e-04  1.611678e-04
## ASV0855      1.107098e-03  1.156626e-03  1.208242e-03  1.262023e-03
## ASV10092     4.443406e-04  4.624767e-04  4.812616e-04  5.007137e-04
## ASV1532      6.383591e-04  6.691007e-04  7.013240e-04  7.350993e-04
## ASV2553      1.467468e-03  1.532955e-03  1.601192e-03  1.672280e-03
## ASV2741      6.235673e-04  6.535412e-04  6.849235e-04  7.177748e-04
## ASV4095      3.636119e-04  3.825101e-04  4.023785e-04  4.232617e-04
## ASV5295      3.839901e-04  3.977569e-04  4.118489e-04  4.262614e-04
## ASV5787     -8.848197e-05 -9.564673e-05 -1.033339e-04 -1.115748e-04
## ASV9455      5.446232e-04  5.671408e-04  5.904857e-04  6.146833e-04
## ASV10879     5.807710e-04  6.060107e-04  6.322799e-04  6.596175e-04
## ASV3997      4.365661e-04  4.575928e-04  4.795923e-04  5.026035e-04
## ASV6760      6.703571e-05  6.649555e-05  6.568236e-05  6.457148e-05
## ASV6990      3.991893e-04  4.149699e-04  4.312758e-04  4.481193e-04
## ASV9560      2.368516e-04  2.454210e-04  2.542241e-04  2.632645e-04
## ASV0220      2.464655e-04  2.576908e-04  2.694022e-04  2.816185e-04
## ASV2518      5.870491e-04  6.138828e-04  6.418931e-04  6.711273e-04
## ASV3615      8.900819e-04  9.287670e-04  9.690013e-04  1.010838e-03
## ASV0075      2.003504e-04  2.086011e-04  2.171453e-04  2.259903e-04
## ASV8070      6.513209e-05  6.495347e-05  6.455173e-05  6.390633e-05
## ASV1658      4.089436e-04  4.258027e-04  4.432752e-04  4.613790e-04
## ASV0773      6.813704e-04  7.101763e-04  7.400777e-04  7.711084e-04
## ASV0799      2.741873e-05  2.882901e-05  3.031389e-05  3.187744e-05
## ASV1839     -1.278517e-04 -1.321977e-04 -1.366067e-04 -1.410710e-04
## ASV0265      7.246015e-04  7.606968e-04  7.986063e-04  8.384192e-04
## ASV3741      2.504330e-04  2.606467e-04  2.712036e-04  2.821093e-04
## ASV0847      9.329842e-04  9.742210e-04  1.017148e-03  1.061824e-03
## ASV1026      9.916330e-04  1.034879e-03  1.079844e-03  1.126584e-03
## ASV1222     -2.647807e-04 -2.735580e-04 -2.824972e-04 -2.915926e-04
## ASV0729      1.430062e-04  1.495159e-04  1.563080e-04  1.633936e-04
## ASV0143     -7.298111e-04 -7.597016e-04 -7.906363e-04 -8.226391e-04
## ASV1328      2.440021e-04  2.563447e-04  2.693215e-04  2.829641e-04
## ASV9078     -2.473224e-04 -2.619484e-04 -2.774440e-04 -2.938568e-04
## ASV0027     -1.128267e-03 -1.180727e-03 -1.235535e-03 -1.292786e-03
## ASV0546     -4.460346e-04 -4.637567e-04 -4.820542e-04 -5.009369e-04
## ASV1136      1.209149e-03  1.262395e-03  1.317838e-03  1.375560e-03
## ASV3081      5.775837e-04  6.036025e-04  6.307624e-04  6.591130e-04
## ASV0531      2.767459e-04  2.903125e-04  3.045342e-04  3.194404e-04
## ASV2525      3.250970e-04  3.387958e-04  3.530146e-04  3.677694e-04
## ASV1083     -9.218930e-05 -9.425542e-05 -9.626683e-05 -9.821377e-05
## ASV0424      2.061617e-04  2.150135e-04  2.242094e-04  2.337604e-04
## ASV0644      7.305154e-05  7.897240e-05  8.532578e-05  9.213788e-05
## ASV6007     -8.690948e-05 -9.396625e-05 -1.015405e-04 -1.096638e-04
## ASV0564      3.271861e-04  3.436241e-04  3.608794e-04  3.789890e-04
## ASV1938      2.837322e-04  2.938942e-04  3.043048e-04  3.149630e-04
## ASV6516     -7.406431e-04 -7.734461e-04 -8.076107e-04 -8.431873e-04
## ASV0503     -8.129366e-04 -8.449795e-04 -8.780283e-04 -9.120951e-04
## ASV6913     -8.530806e-04 -8.893187e-04 -9.269762e-04 -9.661028e-04
## ASV0164     -7.038299e-04 -7.369299e-04 -7.715625e-04 -8.077962e-04
## ASV1576      8.215258e-04  8.581195e-04  8.962738e-04  9.360518e-04
## ASV1725      4.452964e-04  4.677806e-04  4.913840e-04  5.161573e-04
## ASV4501      3.057189e-04  3.163658e-04  3.272300e-04  3.383037e-04
## ASV10678    -7.243031e-04 -7.561153e-04 -7.892214e-04 -8.236663e-04
## ASV0944      6.186698e-04  6.478901e-04  6.784732e-04  7.104811e-04
## ASV2292      9.169033e-04  9.561276e-04  9.968587e-04  1.039142e-03
## ASV1090      6.104511e-04  6.376073e-04  6.659041e-04  6.953849e-04
## ASV9117     -2.519299e-04 -2.603560e-04 -2.689444e-04 -2.776902e-04
## ASV0285     -4.223343e-04 -4.448385e-04 -4.685654e-04 -4.935797e-04
## ASV0463     -5.611855e-04 -5.836127e-04 -6.067651e-04 -6.306527e-04
## ASV3199      4.787836e-04  4.974907e-04  5.167844e-04  5.366731e-04
## ASV0150     -2.334806e-04 -2.454265e-04 -2.579846e-04 -2.711845e-04
## ASV6583     -2.614815e-04 -2.708641e-04 -2.805006e-04 -2.903947e-04
## ASV0392      4.813786e-04  5.025658e-04  5.246176e-04  5.475643e-04
## ASV14007    -5.723129e-04 -5.964141e-04 -6.214031e-04 -6.473027e-04
## ASV0177     -2.991094e-04 -3.104263e-04 -3.220499e-04 -3.339783e-04
## ASV6448     -3.084617e-04 -3.258059e-04 -3.441321e-04 -3.634918e-04
## ASV5399     -1.505616e-04 -1.604522e-04 -1.709787e-04 -1.821772e-04
## ASV0277     -1.244934e-04 -1.301760e-04 -1.360968e-04 -1.422631e-04
## ASV2599      1.852076e-04  1.910028e-04  1.968767e-04  2.028239e-04
## ASV13465    -1.359092e-04 -1.392287e-04 -1.424984e-04 -1.457054e-04
## ASV2412      3.103152e-04  3.243970e-04  3.390929e-04  3.544281e-04
## ASV0423      6.354638e-04  6.665396e-04  6.991503e-04  7.333714e-04
## ASV5187      3.206201e-04  3.316496e-04  3.429237e-04  3.544396e-04
## ASV0701     -1.463955e-03 -1.531295e-03 -1.601622e-03 -1.675057e-03
## ASV4248      3.872419e-04  4.071356e-04  4.280489e-04  4.500306e-04
## ASV0519      6.251140e-04  6.547867e-04  6.858301e-04  7.183022e-04
## ASV0764      1.197354e-04  1.265068e-04  1.336733e-04  1.412571e-04
## ASV5385     -7.623077e-04 -7.974156e-04 -8.340982e-04 -8.724234e-04
## ASV3021     -3.912092e-04 -4.058925e-04 -4.210060e-04 -4.365557e-04
## ASV4119     -2.050651e-04 -2.120466e-04 -2.191824e-04 -2.264721e-04
## ASV2534      1.024759e-04  1.062011e-04  1.100276e-04  1.139562e-04
## ASV1061      6.236042e-04  6.557323e-04  6.895643e-04  7.251915e-04
## ASV0670      8.165790e-04  8.543188e-04  8.937577e-04  9.349687e-04
## ASV1384      3.788246e-04  3.980273e-04  4.181905e-04  4.393580e-04
## ASV1981      7.725029e-04  8.088010e-04  8.467579e-04  8.864438e-04
## ASV9632     -1.797117e-04 -1.839317e-04 -1.880716e-04 -1.921142e-04
## ASV4564      1.912805e-04  2.003550e-04  2.098471e-04  2.197739e-04
## ASV5289     -1.813832e-04 -1.902803e-04 -1.996276e-04 -2.094492e-04
## ASV0516      1.529158e-03  1.598466e-03  1.670748e-03  1.746117e-03
## ASV1463     -5.346992e-04 -5.574558e-04 -5.810715e-04 -6.055701e-04
## ASV0969      2.422381e-04  2.520371e-04  2.621563e-04  2.725998e-04
## ASV1113     -7.103806e-04 -7.425412e-04 -7.760863e-04 -8.110695e-04
## ASV1234     -7.963648e-05 -8.713089e-05 -9.528258e-05 -1.041444e-04
## ASV3814      3.792881e-05  3.562848e-05  3.295815e-05  2.988848e-05
## ASV1000      7.083914e-04  7.388953e-04  7.705775e-04  8.034727e-04
## ASV0079     -8.238446e-05 -8.776028e-05 -9.350303e-05 -9.963746e-05
## ASV0145      2.161154e-04  2.240662e-04  2.322324e-04  2.406148e-04
## ASV0457     -8.957718e-04 -9.341996e-04 -9.741035e-04 -1.015527e-03
## ASV1485      3.091977e-04  3.241247e-04  3.397786e-04  3.561951e-04
## ASV0535     -1.739407e-04 -1.805011e-04 -1.872564e-04 -1.942099e-04
## ASV0259     -5.997939e-04 -6.264768e-04 -6.542533e-04 -6.831593e-04
## ASV0570      6.252916e-05  6.690811e-05  7.159779e-05  7.661912e-05
## ASV0906      7.537737e-04  7.861128e-04  8.197016e-04  8.545783e-04
## ASV1748     -4.999225e-04 -5.254831e-04 -5.523524e-04 -5.805936e-04
## ASV5520     -3.144490e-04 -3.317694e-04 -3.500479e-04 -3.693332e-04
## ASV2288     -8.967840e-04 -9.358210e-04 -9.764083e-04 -1.018596e-03
## ASV1887     -2.135973e-04 -2.258071e-04 -2.386919e-04 -2.522832e-04
## ASV0374     -2.569911e-04 -2.668840e-04 -2.770662e-04 -2.875391e-04
## ASV0823      8.345006e-04  8.693989e-04  9.055930e-04  9.431204e-04
## ASV0717      4.394781e-04  4.594188e-04  4.802179e-04  5.019084e-04
## ASV0431      3.067108e-04  3.201823e-04  3.342042e-04  3.487963e-04
## ASV1030      1.319652e-03  1.382457e-03  1.448206e-03  1.517031e-03
## ASV1082     -1.894822e-04 -1.981270e-04 -2.071435e-04 -2.165453e-04
## ASV2684      1.556523e-04  1.649808e-04  1.748506e-04  1.852883e-04
## ASV0051      1.128257e-03  1.179831e-03  1.233677e-03  1.289887e-03
## ASV0513      6.742963e-05  7.160716e-05  7.606370e-05  8.081849e-05
## ASV0581      1.460136e-03  1.527239e-03  1.597311e-03  1.670471e-03
## ASV7282      2.739573e-04  2.885124e-04  3.038725e-04  3.200833e-04
## ASV3009     -7.927549e-04 -8.286733e-04 -8.661362e-04 -9.052028e-04
## ASV2106     -3.738687e-04 -3.890064e-04 -4.046832e-04 -4.209148e-04
## ASV1012      2.746588e-04  2.884490e-04  3.029184e-04  3.180973e-04
## ASV0921     -7.687923e-06 -7.248720e-06 -6.714997e-06 -6.075793e-06
## ASV0010     -1.147183e-03 -1.200603e-03 -1.256423e-03 -1.314742e-03
## ASV1178      4.012514e-05  4.287748e-05  4.580902e-05  4.892935e-05
## ASV2848     -5.793938e-04 -6.041855e-04 -6.299637e-04 -6.567642e-04
## ASV0586      1.659095e-03  1.735735e-03  1.815804e-03  1.899443e-03
## ASV4225      1.387447e-04  1.489181e-04  1.597897e-04  1.714006e-04
## ASV2156     -6.942265e-04 -7.263171e-04 -7.598436e-04 -7.948657e-04
## ASV9778     -4.258947e-04 -4.447774e-04 -4.644447e-04 -4.849253e-04
## ASV0493     -9.139354e-04 -9.529449e-04 -9.934524e-04 -1.035503e-03
## ASV3770      1.213378e-04  1.244258e-04  1.274892e-04  1.305189e-04
## ASV0470      1.154387e-03  1.206355e-03  1.260543e-03  1.317036e-03
## ASV0262     -5.321194e-04 -5.594858e-04 -5.882741e-04 -6.185560e-04
## ASV0998      7.207368e-04  7.540874e-04  7.889391e-04  8.253561e-04
## ASV7708     -1.718736e-04 -1.783859e-04 -1.850722e-04 -1.919311e-04
## ASV0453     -1.683830e-05 -1.743393e-05 -1.806320e-05 -1.873050e-05
## ASV0044      1.446307e-03  1.511228e-03  1.578898e-03  1.649420e-03
## ASV5490      2.197234e-04  2.287490e-04  2.380763e-04  2.477088e-04
## ASV2638      9.506439e-05  1.008224e-04  1.069228e-04  1.133834e-04
## ASV0829     -1.036956e-04 -1.066892e-04 -1.097006e-04 -1.127255e-04
## ASV0601      2.767727e-04  2.902254e-04  3.043354e-04  3.191345e-04
## ASV0234      6.459809e-04  6.755425e-04  7.064072e-04  7.386285e-04
## ASV0133      8.303491e-04  8.677073e-04  9.066493e-04  9.472337e-04
## ASV0323      9.088788e-04  9.519863e-04  9.971286e-04  1.044400e-03
## ASV0854     -6.501986e-05 -6.741900e-05 -6.987651e-05 -7.239122e-05
## ASV0110      1.123070e-03  1.174583e-03  1.228372e-03  1.284530e-03
## ASV0816      5.718749e-05  5.949185e-05  6.187585e-05  6.434165e-05
## ASV1031     -1.512836e-04 -1.568997e-04 -1.626759e-04 -1.686142e-04
## ASV0144     -4.585988e-04 -4.792252e-04 -5.007312e-04 -5.231501e-04
## ASV0020     -2.325816e-04 -2.455010e-04 -2.591974e-04 -2.737212e-04
## ASV0962     -3.725791e-04 -3.891585e-04 -4.064181e-04 -4.243803e-04
## ASV0794      7.803585e-04  8.185587e-04  8.586121e-04  9.006034e-04
## ASV7117     -3.618301e-04 -3.774713e-04 -3.937309e-04 -4.106293e-04
## ASV1008     -2.867126e-04 -3.008095e-04 -3.156079e-04 -3.311427e-04
## ASV0096      1.207931e-03  1.263277e-03  1.321062e-03  1.381385e-03
## ASV0128     -7.573318e-04 -7.946219e-04 -8.337869e-04 -8.749232e-04
## ASV5232      5.877383e-04  6.162904e-04  6.462200e-04  6.775905e-04
## ASV0031      3.462359e-05  3.560133e-05  3.657544e-05  3.754271e-05
## ASV1744     -7.173701e-05 -7.501907e-05 -7.847584e-05 -8.212019e-05
## ASV0289      6.749503e-04  7.059606e-04  7.383610e-04  7.722117e-04
## ASV7413     -2.059313e-04 -2.187244e-04 -2.323192e-04 -2.467624e-04
## ASV0822     -7.779900e-04 -8.106390e-04 -8.444814e-04 -8.795471e-04
## ASV8111     -6.834951e-04 -7.125950e-04 -7.428376e-04 -7.742628e-04
## ASV0687      5.358036e-04  5.617444e-04  5.889225e-04  6.173930e-04
## ASV0112      1.672967e-04  1.735043e-04  1.798647e-04  1.863749e-04
## ASV0987      4.353437e-04  4.569012e-04  4.795530e-04  5.033561e-04
## ASV5332     -1.714888e-04 -1.768106e-04 -1.822270e-04 -1.877380e-04
## ASV1129     -5.322888e-04 -5.567551e-04 -5.823211e-04 -6.090349e-04
## ASV1274     -1.706451e-04 -1.782952e-04 -1.862696e-04 -1.945809e-04
## ASV0119      9.831029e-04  1.028050e-03  1.074969e-03  1.123941e-03
## ASV0890      2.458000e-04  2.571406e-04  2.689787e-04  2.813334e-04
## ASV0848      1.435529e-03  1.501663e-03  1.570739e-03  1.642875e-03
## ASV5944     -7.629195e-04 -7.968810e-04 -8.322624e-04 -8.691159e-04
## ASV19741    -7.249165e-04 -7.570471e-04 -7.905121e-04 -8.253606e-04
## ASV0504     -8.154538e-04 -8.501055e-04 -8.860735e-04 -9.233964e-04
## ASV2146     -5.177642e-04 -5.395835e-04 -5.622531e-04 -5.858037e-04
## ASV0089     -4.571453e-04 -4.782133e-04 -5.002138e-04 -5.231842e-04
## ASV2301     -5.029428e-04 -5.264965e-04 -5.511307e-04 -5.768924e-04
## ASV2982      2.363283e-04  2.506778e-04  2.658910e-04  2.820149e-04
## ASV0891     -6.130165e-04 -6.403436e-04 -6.688087e-04 -6.984525e-04
## ASV0093      1.007799e-03  1.053346e-03  1.100852e-03  1.150391e-03
## ASV0042      4.886418e-04  5.107421e-04  5.337939e-04  5.578343e-04
## ASV0980      6.496992e-04  6.774932e-04  7.063401e-04  7.362684e-04
## ASV0069     -1.687459e-04 -1.768857e-04 -1.854144e-04 -1.943498e-04
## ASV1364     -1.029962e-04 -1.069984e-04 -1.111150e-04 -1.153456e-04
## ASV0524     -2.037974e-04 -2.139727e-04 -2.246681e-04 -2.359104e-04
## ASV0435      1.360601e-03  1.423685e-03  1.489613e-03  1.558508e-03
## ASV0517     -5.581223e-04 -5.840833e-04 -6.112240e-04 -6.395956e-04
## ASV3167     -2.591356e-04 -2.721915e-04 -2.859118e-04 -3.003298e-04
## ASV4280     -7.478895e-05 -7.767098e-05 -8.064458e-05 -8.371212e-05
## ASV1158      3.611616e-04  3.792931e-04  3.983037e-04  4.182302e-04
## ASV2214      2.342661e-04  2.444054e-04  2.549705e-04  2.659803e-04
## ASV0544     -3.206092e-04 -3.361778e-04 -3.525056e-04 -3.696292e-04
## ASV5326     -5.523882e-05 -5.775598e-05 -6.039049e-05 -6.314867e-05
## ASV3765     -8.006007e-04 -8.368715e-04 -8.746990e-04 -9.141423e-04
## ASV4646     -4.983127e-05 -5.425177e-05 -5.900952e-05 -6.412544e-05
## ASV0090      7.307133e-05  7.551076e-05  7.797810e-05  8.046780e-05
## ASV3680      6.909501e-04  7.188843e-04  7.477479e-04  7.775559e-04
## ASV0111      1.172901e-04  1.218227e-04  1.264818e-04  1.312664e-04
## ASV0768      4.791416e-04  5.020787e-04  5.261177e-04  5.513118e-04
## ASV4862     -1.289389e-05 -1.261490e-05 -1.224328e-05 -1.176791e-05
## ASV1742     -5.647072e-04 -5.878930e-04 -6.119109e-04 -6.367831e-04
## ASV3701     -6.488710e-05 -6.649722e-05 -6.808756e-05 -6.965234e-05
## ASV2386     -3.667567e-04 -3.832924e-04 -4.005289e-04 -4.184919e-04
## ASV0375     -8.275510e-04 -8.632187e-04 -9.002948e-04 -9.388260e-04
## ASV2796      2.017930e-04  2.097606e-04  2.180015e-04  2.265239e-04
## ASV1369      5.692365e-04  5.939841e-04  6.197511e-04  6.465774e-04
## ASV10272    -5.257619e-04 -5.488855e-04 -5.729424e-04 -5.979630e-04
## ASV10354    -5.256576e-04 -5.487719e-04 -5.728186e-04 -5.978282e-04
## ASV1067     -3.921910e-05 -4.088905e-05 -4.262085e-05 -4.441598e-05
## ASV1900      1.131149e-03  1.183508e-03  1.238220e-03  1.295384e-03
## ASV4079     -1.985285e-04 -2.080762e-04 -2.180756e-04 -2.285467e-04
## ASV4149      7.121739e-04  7.413781e-04  7.715897e-04  8.028288e-04
## ASV5140     -5.255516e-04 -5.486562e-04 -5.726924e-04 -5.976905e-04
## ASV10782    -5.751260e-06 -4.782529e-06 -3.660554e-06 -2.369475e-06
## ASV4273     -1.103730e-04 -1.143243e-04 -1.183516e-04 -1.224496e-04
## ASV8121      5.166281e-04  5.404081e-04  5.652530e-04  5.912084e-04
## ASV8438     -5.254695e-04 -5.485675e-04 -5.725967e-04 -5.975874e-04
## ASV9390     -5.253653e-04 -5.484541e-04 -5.724731e-04 -5.974528e-04
## ASV1340      7.537131e-04  7.889685e-04  8.258351e-04  8.643826e-04
## ASV2650     -7.709524e-04 -8.040275e-04 -8.383678e-04 -8.740092e-04
## ASV4674      4.037176e-04  4.219019e-04  4.408562e-04  4.606084e-04
## ASV10492    -2.598416e-05 -2.692223e-05 -2.788337e-05 -2.886750e-05
## ASV11430    -5.252188e-04 -5.482949e-04 -5.723004e-04 -5.972655e-04
## ASV12135    -5.251147e-04 -5.481816e-04 -5.721769e-04 -5.971311e-04
## ASV14970    -5.250107e-04 -5.480682e-04 -5.720535e-04 -5.969967e-04
## ASV1954      6.123493e-04  6.402327e-04  6.693222e-04  6.996637e-04
## ASV2613      9.461417e-04  9.885944e-04  1.032839e-03  1.078941e-03
## ASV2757      3.591703e-04  3.740238e-04  3.894020e-04  4.053168e-04
## ASV2909     -5.756438e-04 -6.027452e-04 -6.311071e-04 -6.607865e-04
## ASV2954     -1.045338e-04 -1.087912e-04 -1.131900e-04 -1.177322e-04
## ASV2969      5.443954e-04  5.704614e-04  5.977734e-04  6.263903e-04
## ASV3410      1.186392e-04  1.248249e-04  1.313486e-04  1.382293e-04
## ASV3575      2.755220e-04  2.879509e-04  3.009168e-04  3.144414e-04
## ASV4275      5.891290e-04  6.140708e-04  6.399380e-04  6.667544e-04
## ASV4652      1.151667e-04  1.212952e-04  1.277652e-04  1.345961e-04
## ASV4761      5.890657e-04  6.139936e-04  6.398380e-04  6.666205e-04
## ASV6003      4.866606e-04  5.104647e-04  5.354519e-04  5.616819e-04
## ASV6110     -5.252469e-04 -5.483268e-04 -5.723366e-04 -5.973065e-04
## ASV7427      3.417570e-04  3.569254e-04  3.727184e-04  3.891577e-04
## ASV8092     -5.251797e-04 -5.482537e-04 -5.722569e-04 -5.972198e-04
## ASV8169     -5.250757e-04 -5.481403e-04 -5.721335e-04 -5.970854e-04
## ASV9693      2.339160e-04  2.445899e-04  2.557266e-04  2.673436e-04
## ASV10913     2.621792e-04  2.747607e-04  2.879443e-04  3.017580e-04
## ASV1979     -7.951107e-05 -8.264403e-05 -8.587594e-05 -8.920831e-05
## ASV3772      6.461285e-04  6.743152e-04  7.036300e-04  7.341103e-04
## ASV0113      1.280715e-04  1.335638e-04  1.392705e-04  1.451988e-04
## ASV1800     -4.961732e-05 -5.152816e-05 -5.347729e-05 -5.546087e-05
## ASV2335     -6.744989e-04 -7.034988e-04 -7.336569e-04 -7.650148e-04
## ASV0692      2.282487e-04  2.387002e-04  2.496054e-04  2.609811e-04
## ASV1120      2.962949e-04  3.100048e-04  3.243323e-04  3.393039e-04
## ASV1434     -1.559981e-03 -1.631615e-03 -1.706423e-03 -1.784537e-03
## ASV0076     -1.767308e-04 -1.851967e-04 -1.940624e-04 -2.033458e-04
## ASV0361      1.169276e-03  1.223165e-03  1.279459e-03  1.338255e-03
## ASV2231     -4.155970e-04 -4.369449e-04 -4.594284e-04 -4.831089e-04
## ASV2018     -1.869793e-05 -1.975092e-05 -2.087184e-05 -2.206588e-05
## ASV1529      9.935239e-04  1.040648e-03  1.089993e-03  1.141661e-03
## ASV0841     -3.902299e-05 -4.005428e-05 -4.106629e-05 -4.205305e-05
## ASV2556     -5.736247e-04 -5.990086e-04 -6.254323e-04 -6.529315e-04
## ASV2777      6.918171e-04  7.198763e-04  7.488748e-04  7.788286e-04
## ASV0355      6.007109e-04  6.282987e-04  6.571127e-04  6.872041e-04
## ASV5169     -8.320833e-04 -8.697175e-04 -9.089589e-04 -9.498673e-04
## ASV3091      4.126199e-04  4.323728e-04  4.530723e-04  4.747633e-04
## ASV2435      5.884042e-04  6.149069e-04  6.425343e-04  6.713280e-04
## ASV6822     -3.639313e-04 -3.796104e-04 -3.958921e-04 -4.127933e-04
## ASV12605    -9.045257e-04 -9.454065e-04 -9.880381e-04 -1.032487e-03
## ASV0286     -5.948711e-04 -6.216398e-04 -6.495721e-04 -6.787169e-04
## ASV0074     -4.198662e-05 -4.528300e-05 -4.883446e-05 -5.265947e-05
## ASV2485     -5.747819e-05 -6.126133e-05 -6.532774e-05 -6.970022e-05
## ASV1233     -1.158543e-03 -1.211741e-03 -1.267306e-03 -1.325339e-03
## ASV0356     -5.349793e-04 -5.583461e-04 -5.826637e-04 -6.079663e-04
## ASV2918     -6.890651e-04 -7.196433e-04 -7.514912e-04 -7.846547e-04
## ASV1427     -2.605316e-06 -3.148977e-06 -3.756795e-06 -4.435211e-06
## ASV1409      6.849940e-04  7.174501e-04  7.514319e-04  7.870094e-04
## ASV0770      2.061114e-04  2.144493e-04  2.230553e-04  2.319317e-04
## ASV1403     -8.042541e-04 -8.403204e-04 -8.779090e-04 -9.170760e-04
## ASV0314     -4.386018e-04 -4.584369e-04 -4.791146e-04 -5.006652e-04
## ASV0187     -5.867553e-06 -7.308992e-06 -8.900675e-06 -1.065427e-05
## ASV0313     -5.908079e-04 -6.171031e-04 -6.444884e-04 -6.730024e-04
## ASV1087      1.023380e-03  1.070101e-03  1.118869e-03  1.169766e-03
## ASV1970      5.902471e-05  6.164417e-05  6.437703e-05  6.722848e-05
## ASV0754      8.266913e-04  8.645700e-04  9.041201e-04  9.454101e-04
## ASV3775     -5.726795e-04 -5.996421e-04 -6.278570e-04 -6.573807e-04
## ASV0132      2.367078e-04  2.473780e-04  2.585025e-04  2.700984e-04
## ASV2329     -1.826973e-04 -1.928602e-04 -2.035855e-04 -2.149012e-04
## ASV0561      7.069450e-04  7.384052e-04  7.711674e-04  8.052770e-04
## ASV0130     -8.765071e-04 -9.169779e-04 -9.592508e-04 -1.003400e-03
## ASV0226      9.794620e-04  1.023974e-03  1.070412e-03  1.118851e-03
## ASV12648    -6.709505e-04 -7.004198e-04 -7.311172e-04 -7.630906e-04
## ASV0204      9.763071e-04  1.020655e-03  1.066921e-03  1.115179e-03
## ASV0767      1.627818e-04  1.691969e-04  1.758014e-04  1.825950e-04
## ASV0335     -5.344576e-04 -5.588637e-04 -5.843310e-04 -6.109005e-04
## ASV5901     -1.483766e-04 -1.542429e-04 -1.603093e-04 -1.665816e-04
## ASV0596     -2.018695e-04 -2.099147e-04 -2.182103e-04 -2.267580e-04
## ASV9271      2.393821e-04  2.527576e-04  2.668928e-04  2.818288e-04
## ASV0904      8.808668e-04  9.221286e-04  9.652871e-04  1.010426e-03
## ASV15270    -2.664818e-04 -2.805869e-04 -2.954248e-04 -3.110286e-04
## ASV0990     -2.475877e-04 -2.592540e-04 -2.714628e-04 -2.842383e-04
## ASV0155     -5.234469e-04 -5.473040e-04 -5.722027e-04 -5.981846e-04
## ASV0086     -7.974893e-06 -8.375601e-06 -8.796481e-06 -9.238493e-06
## ASV2581     -3.953251e-05 -4.097357e-05 -4.243724e-05 -4.391984e-05
## ASV1579     -6.223894e-04 -6.520041e-04 -6.830143e-04 -7.154837e-04
## ASV7730     -4.467333e-05 -4.808010e-05 -5.170652e-05 -5.556188e-05
## ASV0897      2.639673e-04  2.766745e-04  2.899940e-04  3.039547e-04
## ASV1975      1.185957e-03  1.240296e-03  1.297046e-03  1.356309e-03
##                                                                           
## (Intercept) -1.156824e-05 -1.496869e-05 -1.902778e-05 -2.384636e-05 ......
## ASV1236      6.198859e-04  6.457143e-04  6.724661e-04  7.001626e-04 ......
## ASV0421     -1.125792e-03 -1.174032e-03 -1.224113e-03 -1.276086e-03 ......
## ASV0691     -9.242006e-04 -9.606364e-04 -9.982071e-04 -1.036925e-03 ......
## ASV0899      2.700825e-05  3.035163e-05  3.399224e-05  3.795044e-05 ......
## ASV1004      1.264220e-03  1.317645e-03  1.373035e-03  1.430438e-03 ......
## ASV1041     -8.672923e-04 -9.044493e-04 -9.430120e-04 -9.830176e-04 ......
## ASV1058      1.181300e-03  1.231617e-03  1.283831e-03  1.337993e-03 ......
## ASV12542     3.528055e-04  3.670646e-04  3.818003e-04  3.970209e-04 ......
## ASV1294      1.390505e-03  1.450822e-03  1.513502e-03  1.578616e-03 ......
## ASV13113     5.331166e-04  5.586846e-04  5.854852e-04  6.135782e-04 ......
## ASV1318      1.201292e-03  1.252599e-03  1.305844e-03  1.361081e-03 ......
## ASV2269     -3.607081e-04 -3.761844e-04 -3.922452e-04 -4.089059e-04 ......
## ASV2542      8.099704e-04  8.473821e-04  8.864667e-04  9.272939e-04 ......
## ASV2660     -6.852114e-04 -7.138588e-04 -7.435344e-04 -7.742615e-04 ......
## ASV2737     -4.891964e-05 -5.174196e-05 -5.472503e-05 -5.787686e-05 ......
## ASV2840      9.051148e-04  9.425030e-04  9.811919e-04  1.021207e-03 ......
## ASV3053      4.613013e-05  4.790190e-05  4.972994e-05  5.161548e-05 ......
## ASV3077      2.842551e-04  2.962440e-04  3.086790e-04  3.215722e-04 ......
## ASV3134      1.061502e-03  1.111658e-03  1.164166e-03  1.219132e-03 ......
## ASV3140      4.598461e-04  4.809220e-04  5.029121e-04  5.258507e-04 ......
## ASV3579      2.005869e-04  2.111184e-04  2.222313e-04  2.339587e-04 ......
## ASV6119     -3.605483e-04 -3.760112e-04 -3.920576e-04 -4.087028e-04 ......
## ASV7557     -3.604637e-04 -3.759192e-04 -3.919577e-04 -4.085943e-04 ......
## ASV8422      1.815827e-04  1.885214e-04  1.956653e-04  2.030166e-04 ......
## ASV1086     -9.593625e-05 -9.982111e-05 -1.038406e-04 -1.079980e-04 ......
## ASV1310      6.806412e-04  7.098552e-04  7.401827e-04  7.716542e-04 ......
## ASV15750    -1.673231e-04 -1.741878e-04 -1.812788e-04 -1.885983e-04 ......
## ASV16905    -3.604258e-04 -3.758778e-04 -3.919126e-04 -4.085451e-04 ......
## ASV2033      6.995981e-04  7.317121e-04  7.652413e-04  8.002420e-04 ......
## ASV2089      2.481589e-04  2.588638e-04  2.699760e-04  2.815060e-04 ......
## ASV2127      9.717677e-04  1.013088e-03  1.055960e-03  1.100428e-03 ......
## ASV2725      1.081807e-03  1.126420e-03  1.172590e-03  1.220347e-03 ......
## ASV2804     -3.604071e-04 -3.758579e-04 -3.918914e-04 -4.085226e-04 ......
## ASV3075      7.038162e-04  7.343510e-04  7.661002e-04  7.991042e-04 ......
## ASV3327      6.876216e-04  7.193218e-04  7.524393e-04  7.870335e-04 ......
## ASV3342      7.392400e-04  7.724604e-04  8.070808e-04  8.431521e-04 ......
## ASV3532     -6.710499e-04 -7.013725e-04 -7.329913e-04 -7.659553e-04 ......
## ASV3600      8.353410e-04  8.724605e-04  9.111224e-04  9.513821e-04 ......
## ASV4013      6.908073e-04  7.205423e-04  7.514235e-04  7.834843e-04 ......
## ASV4136      6.697317e-04  6.975648e-04  7.263901e-04  7.562303e-04 ......
## ASV4195      3.602886e-04  3.757294e-04  3.917521e-04  4.083717e-04 ......
## ASV4407     -3.602042e-04 -3.756376e-04 -3.916523e-04 -4.082632e-04 ......
## ASV4717      1.746397e-06  9.040475e-07 -3.686758e-08 -1.083365e-06 ......
## ASV6794      3.412506e-04  3.544151e-04  3.679747e-04  3.819335e-04 ......
## ASV8324     -3.601662e-04 -3.755955e-04 -3.916058e-04 -4.082119e-04 ......
## ASV8981     -8.772856e-05 -9.066679e-05 -9.363699e-05 -9.663225e-05 ......
## ASV9859      3.072633e-04  3.228602e-04  3.392831e-04  3.565778e-04 ......
## ASV0936     -5.695454e-04 -5.944146e-04 -6.202773e-04 -6.471659e-04 ......
## ASV12683    -6.503209e-05 -6.824489e-05 -7.160893e-05 -7.513007e-05 ......
## ASV1293      8.191887e-04  8.536344e-04  8.893365e-04  9.263254e-04 ......
## ASV13055    -8.282604e-05 -8.593257e-05 -8.910976e-05 -9.235454e-05 ......
## ASV17063    -3.600414e-04 -3.754616e-04 -3.914621e-04 -4.080580e-04 ......
## ASV2228      3.599571e-04  3.753699e-04  3.913624e-04  4.079497e-04 ......
## ASV2769     -6.120449e-05 -6.322521e-05 -6.526732e-05 -6.732649e-05 ......
## ASV2803      1.528088e-04  1.584485e-04  1.642362e-04  1.701716e-04 ......
## ASV2896      4.607009e-04  4.814536e-04  5.031083e-04  5.257027e-04 ......
## ASV3062      1.552620e-04  1.633521e-04  1.718829e-04  1.808790e-04 ......
## ASV3107      5.595375e-04  5.847726e-04  6.110884e-04  6.385263e-04 ......
## ASV3265      1.069240e-03  1.114378e-03  1.161180e-03  1.209688e-03 ......
## ASV3666     -2.572374e-05 -2.690886e-05 -2.814447e-05 -2.943248e-05 ......
## ASV4497      2.566922e-04  2.677767e-04  2.792962e-04  2.912642e-04 ......
## ASV6914     -1.326659e-04 -1.387291e-04 -1.450516e-04 -1.516426e-04 ......
## ASV0576     -1.221141e-03 -1.270307e-03 -1.321095e-03 -1.373531e-03 ......
## ASV0673      3.685458e-04  3.866145e-04  4.055597e-04  4.254208e-04 ......
## ASV0772      3.852865e-04  4.020241e-04  4.194302e-04  4.375274e-04 ......
## ASV0862     -2.997966e-04 -3.117602e-04 -3.241039e-04 -3.368319e-04 ......
## ASV0898      3.425924e-04  3.589927e-04  3.761666e-04  3.941487e-04 ......
## ASV0910      7.314045e-04  7.658206e-04  8.018246e-04  8.394858e-04 ......
## ASV0964     -4.570826e-04 -4.762496e-04 -4.961117e-04 -5.166854e-04 ......
## ASV10059     3.513014e-04  3.684360e-04  3.864225e-04  4.053040e-04 ......
## ASV10263    -3.604224e-04 -3.758774e-04 -3.919159e-04 -4.085532e-04 ......
## ASV1088      3.885456e-04  4.070386e-04  4.264191e-04  4.467308e-04 ......
## ASV1101      6.290345e-04  6.564112e-04  6.848577e-04  7.144045e-04 ......
## ASV1183      4.117450e-04  4.302304e-04  4.494908e-04  4.695542e-04 ......
## ASV11956     1.323603e-04  1.368408e-04  1.414030e-04  1.460432e-04 ......
## ASV12774    -6.263498e-05 -6.580927e-05 -6.914297e-05 -7.264356e-05 ......
## ASV1321      1.846243e-04  1.944877e-04  2.049003e-04  2.158929e-04 ......
## ASV13793    -3.603167e-04 -3.757621e-04 -3.917903e-04 -4.084163e-04 ......
## ASV14482    -4.416133e-05 -4.663176e-05 -4.923592e-05 -5.197983e-05 ......
## ASV15483     2.617611e-04  2.737641e-04  2.863024e-04  2.993986e-04 ......
## ASV2062      1.602730e-03  1.672924e-03  1.745931e-03  1.821841e-03 ......
## ASV2132      7.519707e-04  7.864973e-04  8.225555e-04  8.602087e-04 ......
## ASV2413      1.014531e-03  1.057663e-03  1.102421e-03  1.148853e-03 ......
## ASV2490      6.459356e-04  6.720613e-04  6.990529e-04  7.269239e-04 ......
## ASV2594      3.721658e-04  3.886114e-04  4.057499e-04  4.236094e-04 ......
## ASV2822     -3.604637e-04 -3.759231e-04 -3.919666e-04 -4.086094e-04 ......
## ASV2863      6.143321e-04  6.400082e-04  6.666095e-04  6.941581e-04 ......
## ASV2910      7.979165e-04  8.311497e-04  8.655736e-04  9.012156e-04 ......
## ASV2980      2.942445e-04  3.066315e-04  3.194636e-04  3.327501e-04 ......
## ASV3307      3.603230e-04  3.757702e-04  3.918005e-04  4.084290e-04 ......
## ASV3474      5.941815e-04  6.221594e-04  6.514330e-04  6.820593e-04 ......
## ASV3502      1.189992e-03  1.242568e-03  1.297298e-03  1.354256e-03 ......
## ASV4236      5.853152e-04  6.097910e-04  6.351484e-04  6.614075e-04 ......
## ASV4842     -2.037986e-04 -2.128562e-04 -2.222772e-04 -2.320722e-04 ......
## ASV4894     -3.604269e-04 -3.758840e-04 -3.919251e-04 -4.085654e-04 ......
## ASV5290      4.442032e-04  4.636725e-04  4.839276e-04  5.049949e-04 ......
## ASV5501      8.345251e-05  8.717739e-05  9.106502e-05  9.512252e-05 ......
## ASV5795      3.066600e-04  3.206687e-04  3.352927e-04  3.505566e-04 ......
## ASV5987     -3.604645e-04 -3.759254e-04 -3.919707e-04 -4.086158e-04 ......
## ASV6267     -3.603799e-04 -3.758335e-04 -3.918708e-04 -4.085072e-04 ......
## ASV6862      6.606427e-04  6.871528e-04  7.145337e-04  7.427996e-04 ......
## ASV7145      1.095924e-04  1.134666e-04  1.174322e-04  1.214887e-04 ......
## ASV7673     -3.603481e-04 -3.757984e-04 -3.918322e-04 -4.084648e-04 ......
## ASV7789      1.506314e-04  1.587197e-04  1.672689e-04  1.763061e-04 ......
## ASV7809     -3.798368e-05 -3.892997e-05 -3.984697e-05 -4.072770e-05 ......
## ASV8002     -3.602956e-04 -3.757424e-04 -3.917725e-04 -4.084012e-04 ......
## ASV8205      2.044641e-04  2.132965e-04  2.224846e-04  2.320413e-04 ......
## ASV9155     -2.696250e-04 -2.810322e-04 -2.928544e-04 -3.051007e-04 ......
## ASV9221     -4.261624e-05 -4.411097e-05 -4.563118e-05 -4.717484e-05 ......
## ASV9311     -3.601813e-04 -3.756184e-04 -3.916381e-04 -4.082556e-04 ......
## ASV9557     -3.600969e-04 -3.755266e-04 -3.915383e-04 -4.081472e-04 ......
## ASV9936     -3.600125e-04 -3.754349e-04 -3.914386e-04 -4.080388e-04 ......
## ASV1445      8.547868e-04  8.934821e-04  9.338435e-04  9.759358e-04 ......
## ASV4232      7.302206e-04  7.641564e-04  7.996418e-04  8.367456e-04 ......
## ASV6479      2.617162e-05  2.936974e-05  3.288290e-05  3.673815e-05 ......
## ASV0142     -1.775803e-03 -1.849662e-03 -1.926158e-03 -2.005351e-03 ......
## ASV0378     -5.842196e-04 -6.081965e-04 -6.329862e-04 -6.586012e-04 ......
## ASV1122      1.128233e-03  1.179225e-03  1.232401e-03  1.287841e-03 ......
## ASV0123     -1.738231e-03 -1.810421e-03 -1.885179e-03 -1.962563e-03 ......
## ASV2064      1.608770e-04  1.667481e-04  1.727801e-04  1.789748e-04 ......
## ASV4459     -2.010595e-04 -2.097544e-04 -2.187837e-04 -2.281570e-04 ......
## ASV0448      3.528274e-04  3.708063e-04  3.897215e-04  4.096214e-04 ......
## ASV0397      8.423140e-04  8.800641e-04  9.194014e-04  9.603837e-04 ......
## ASV0485      1.149459e-03  1.199378e-03  1.251274e-03  1.305210e-03 ......
## ASV1566      9.767409e-04  1.020034e-03  1.065103e-03  1.112008e-03 ......
## ASV1365      6.274955e-04  6.551866e-04  6.840069e-04  7.139943e-04 ......
## ASV1065      1.303467e-03  1.361636e-03  1.422231e-03  1.485340e-03 ......
## ASV0722     -2.429954e-05 -2.522288e-05 -2.618046e-05 -2.717420e-05 ......
## ASV12660    -5.830947e-04 -6.071125e-04 -6.319658e-04 -6.576719e-04 ......
## ASV0223     -1.952635e-05 -2.011912e-05 -2.071093e-05 -2.129914e-05 ......
## ASV0229      5.937481e-04  6.209985e-04  6.494519e-04  6.791572e-04 ......
## ASV0877     -2.246234e-04 -2.339726e-04 -2.436398e-04 -2.536295e-04 ......
## ASV0983      1.165561e-03  1.215475e-03  1.267290e-03  1.321058e-03 ......
## ASV0626     -3.435854e-04 -3.556235e-04 -3.678915e-04 -3.803770e-04 ......
## ASV4146     -6.840516e-05 -7.144263e-05 -7.460647e-05 -7.790172e-05 ......
## ASV4175     -7.235141e-04 -7.551759e-04 -7.880976e-04 -8.223185e-04 ......
## ASV2082     -6.524511e-05 -6.929087e-05 -7.361599e-05 -7.824104e-05 ......
## ASV2272      5.265086e-04  5.501469e-04  5.747913e-04  6.004802e-04 ......
## ASV2245     -6.374290e-04 -6.657902e-04 -6.953216e-04 -7.260636e-04 ......
## ASV0590     -4.100927e-04 -4.301657e-04 -4.512328e-04 -4.733432e-04 ......
## ASV0217     -5.073934e-04 -5.242171e-04 -5.412604e-04 -5.584935e-04 ......
## ASV0416      5.491045e-04  5.704297e-04  5.923813e-04  6.149612e-04 ......
## ASV1056      7.392839e-04  7.744124e-04  8.111875e-04  8.496825e-04 ......
## ASV7777     -6.417444e-04 -6.707165e-04 -7.009283e-04 -7.324277e-04 ......
## ASV0455      1.343870e-04  1.408000e-04  1.475042e-04  1.545106e-04 ......
## ASV0604      1.721438e-04  1.819700e-04  1.923825e-04  2.034157e-04 ......
## ASV6100     -5.931804e-04 -6.200174e-04 -6.480061e-04 -6.771909e-04 ......
## ASV11359    -6.387801e-04 -6.663136e-04 -6.949059e-04 -7.245870e-04 ......
## ASV6604      4.761739e-04  4.982817e-04  5.213924e-04  5.455491e-04 ......
## ASV5004     -3.808776e-04 -3.975229e-04 -4.148276e-04 -4.328121e-04 ......
## ASV1483     -3.599134e-04 -3.761255e-04 -3.930253e-04 -4.106386e-04 ......
## ASV9773     -7.548674e-04 -7.887410e-04 -8.240429e-04 -8.608256e-04 ......
## ASV4059      8.448540e-05  8.931201e-05  9.443455e-05  9.987180e-05 ......
## ASV1193      1.218241e-03  1.272423e-03  1.328851e-03  1.387605e-03 ......
## ASV4610     -7.662478e-05 -7.794687e-05 -7.915761e-05 -8.024123e-05 ......
## ASV0742     -4.081336e-04 -4.230148e-04 -4.382412e-04 -4.538041e-04 ......
## ASV1502     -2.264575e-05 -2.466582e-05 -2.685260e-05 -2.921845e-05 ......
## ASV0195     -1.549141e-04 -1.631453e-04 -1.718230e-04 -1.809700e-04 ......
## ASV1213      3.614581e-04  3.757916e-04  3.905677e-04  4.057897e-04 ......
## ASV1648     -5.579024e-04 -5.828721e-04 -6.088922e-04 -6.360017e-04 ......
## ASV6984     -4.183439e-04 -4.371641e-04 -4.567822e-04 -4.772280e-04 ......
## ASV0396     -2.312012e-04 -2.365563e-04 -2.417396e-04 -2.467161e-04 ......
## ASV4297      5.959672e-04  6.206424e-04  6.461963e-04  6.726496e-04 ......
## ASV2622      1.378824e-03  1.437145e-03  1.497635e-03  1.560350e-03 ......
## ASV3512      2.367680e-04  2.488879e-04  2.616553e-04  2.751060e-04 ......
## ASV2411      5.017445e-04  5.250667e-04  5.494371e-04  5.748991e-04 ......
## ASV2291     -1.401667e-04 -1.476597e-04 -1.555790e-04 -1.639499e-04 ......
## ASV0807      6.206000e-04  6.511933e-04  6.832928e-04  7.169692e-04 ......
## ASV1292      3.166184e-04  3.302627e-04  3.444402e-04  3.591680e-04 ......
## ASV1035      1.281004e-04  1.325078e-04  1.369960e-04  1.415607e-04 ......
## ASV0070     -3.036763e-04 -3.146261e-04 -3.258037e-04 -3.371977e-04 ......
## ASV0255      1.272407e-04  1.323133e-04  1.375355e-04  1.429061e-04 ......
## ASV0057     -1.385645e-03 -1.441665e-03 -1.499531e-03 -1.559269e-03 ......
## ASV0077     -1.840808e-04 -1.900080e-04 -1.959850e-04 -2.019971e-04 ......
## ASV0625      1.403416e-03  1.461787e-03  1.522230e-03  1.584790e-03 ......
## ASV2464      6.667670e-04  6.936879e-04  7.215037e-04  7.502297e-04 ......
## ASV1315      1.264539e-03  1.321889e-03  1.381744e-03  1.444207e-03 ......
## ASV2673      9.635142e-04  1.009056e-03  1.056729e-03  1.106632e-03 ......
## ASV2161      4.040470e-04  4.235216e-04  4.439384e-04  4.653422e-04 ......
## ASV0337     -6.089322e-04 -6.356811e-04 -6.635087e-04 -6.924505e-04 ......
## ASV7680     -7.277783e-04 -7.606102e-04 -7.948410e-04 -8.305236e-04 ......
## ASV0611      1.597949e-03  1.671383e-03  1.748072e-03  1.828152e-03 ......
## ASV3118     -5.451449e-04 -5.701869e-04 -5.963336e-04 -6.236294e-04 ......
## ASV1284      6.077397e-04  6.362609e-04  6.660378e-04  6.971157e-04 ......
## ASV0889      4.166414e-04  4.346197e-04  4.533076e-04  4.727286e-04 ......
## ASV4649     -4.511525e-04 -4.714005e-04 -4.925034e-04 -5.144931e-04 ......
## ASV1108     -6.006742e-04 -6.294138e-04 -6.595240e-04 -6.910689e-04 ......
## ASV0738     -1.434714e-05 -1.015328e-05 -5.372200e-06  5.100784e-08 ......
## ASV0473      7.816999e-05  8.124858e-05  8.442293e-05  8.769418e-05 ......
## ASV0598     -5.999736e-04 -6.236091e-04 -6.479698e-04 -6.730612e-04 ......
## ASV0429      1.026710e-03  1.071475e-03  1.118004e-03  1.166347e-03 ......
## ASV1549      1.078515e-03  1.129794e-03  1.183493e-03  1.239725e-03 ......
## ASV1203      7.594955e-04  7.921168e-04  8.259886e-04  8.611465e-04 ......
## ASV4532      1.699561e-05  1.685645e-05  1.664589e-05  1.635727e-05 ......
## ASV0274     -7.285672e-04 -7.577117e-04 -7.878115e-04 -8.188825e-04 ......
## ASV0163     -1.051586e-03 -1.093665e-03 -1.137099e-03 -1.181904e-03 ......
## ASV1298      4.248528e-04  4.417860e-04  4.592660e-04  4.773013e-04 ......
## ASV9424     -9.750206e-04 -1.019702e-03 -1.066354e-03 -1.115057e-03 ......
## ASV0412      1.443351e-03  1.505935e-03  1.570984e-03  1.638575e-03 ......
## ASV0284      6.191145e-04  6.441932e-04  6.701100e-04  6.968789e-04 ......
## ASV0620     -5.280917e-04 -5.538088e-04 -5.807790e-04 -6.090615e-04 ......
## ASV0153     -1.051399e-03 -1.100277e-03 -1.151365e-03 -1.204758e-03 ......
## ASV0498      1.627306e-04  1.731310e-04  1.842005e-04  1.959784e-04 ......
## ASV0097      7.438991e-04  7.784730e-04  8.146315e-04  8.524462e-04 ......
## ASV0104     -3.348629e-03 -3.496021e-03 -3.649417e-03 -3.809023e-03 ......
## ASV1282      6.183788e-04  6.468475e-04  6.765378e-04  7.074922e-04 ......
## ASV3883     -3.549915e-04 -3.716645e-04 -3.890966e-04 -4.073194e-04 ......
## ASV0801      3.743137e-04  3.930251e-04  4.126795e-04  4.333230e-04 ......
## ASV1611     -1.313198e-03 -1.372578e-03 -1.434505e-03 -1.499078e-03 ......
## ASV0227     -4.968346e-04 -5.208614e-04 -5.460407e-04 -5.724249e-04 ......
## ASV0833      5.420823e-04  5.685759e-04  5.963597e-04  6.254934e-04 ......
## ASV0718      1.211409e-03  1.265411e-03  1.321669e-03  1.380264e-03 ......
## ASV1139      4.039771e-04  4.190783e-04  4.345530e-04  4.503930e-04 ......
## ASV0766     -3.268745e-04 -3.409425e-04 -3.555533e-04 -3.707228e-04 ......
## ASV2091      1.531428e-03  1.594098e-03  1.658936e-03  1.725987e-03 ......
## ASV1238     -1.685809e-05 -1.388227e-05 -1.053323e-05 -6.784430e-06 ......
## ASV9193     -2.348527e-04 -2.488470e-04 -2.636452e-04 -2.792860e-04 ......
## ASV0290     -1.376502e-04 -1.442731e-04 -1.512020e-04 -1.584489e-04 ......
## ASV0231      1.269087e-03  1.324555e-03  1.382245e-03  1.442231e-03 ......
## ASV0185      3.370184e-04  3.591587e-04  3.828198e-04  4.081048e-04 ......
## ASV2330      3.602488e-04  3.754552e-04  3.912229e-04  4.075661e-04 ......
## ASV3119     -4.678672e-04 -4.917582e-04 -5.169028e-04 -5.433669e-04 ......
## ASV2368     -6.108583e-04 -6.397477e-04 -6.699913e-04 -7.016513e-04 ......
## ASV0122     -4.374636e-04 -4.553928e-04 -4.739507e-04 -4.931521e-04 ......
## ASV1044      8.597377e-04  9.016684e-04  9.456573e-04  9.918045e-04 ......
## ASV0160     -1.059396e-03 -1.101347e-03 -1.144617e-03 -1.189219e-03 ......
## ASV0326      7.414443e-04  7.746670e-04  8.092871e-04  8.453553e-04 ......
## ASV1388      1.281310e-03  1.337608e-03  1.396179e-03  1.457098e-03 ......
## ASV0792      1.434627e-03  1.496194e-03  1.560117e-03  1.626463e-03 ......
## ASV0036     -9.452717e-04 -9.887619e-04 -1.034179e-03 -1.081600e-03 ......
## ASV2125      1.493804e-03  1.559251e-03  1.627326e-03  1.698117e-03 ......
## ASV1075      3.048123e-04  3.195168e-04  3.349387e-04  3.511135e-04 ......
## ASV0390      3.216263e-04  3.386083e-04  3.565360e-04  3.754643e-04 ......
## ASV3790     -1.214559e-03 -1.269122e-03 -1.326008e-03 -1.385305e-03 ......
## ASV1535     -1.405439e-04 -1.487232e-04 -1.573931e-04 -1.665827e-04 ......
## ASV0263      2.513781e-04  2.625716e-04  2.742262e-04  2.863574e-04 ......
## ASV0675      2.069637e-03  2.166411e-03  2.267588e-03  2.373354e-03 ......
## ASV3348      2.138813e-04  2.249206e-04  2.365578e-04  2.488267e-04 ......
## ASV0058     -1.852274e-03 -1.932007e-03 -2.014837e-03 -2.100859e-03 ......
## ASV4142      4.738979e-04  4.945361e-04  5.159857e-04  5.382711e-04 ......
## ASV0059     -1.587525e-03 -1.655298e-03 -1.725654e-03 -1.798666e-03 ......
## ASV0013     -3.403057e-03 -3.552998e-03 -3.709060e-03 -3.871456e-03 ......
## ASV0033     -1.034517e-03 -1.082428e-03 -1.132490e-03 -1.184791e-03 ......
## ASV4354     -4.326697e-04 -4.513106e-04 -4.706856e-04 -4.908193e-04 ......
## ASV0022     -1.091934e-03 -1.142441e-03 -1.195209e-03 -1.250333e-03 ......
## ASV0134     -2.892357e-04 -3.037815e-04 -3.190736e-04 -3.351503e-04 ......
## ASV0415     -1.638157e-04 -1.677659e-04 -1.716221e-04 -1.753628e-04 ......
## ASV10103    -7.432546e-04 -7.764538e-04 -8.110365e-04 -8.470519e-04 ......
## ASV1613      1.177020e-03  1.227466e-03  1.279836e-03  1.334186e-03 ......
## ASV0135     -2.259230e-05 -2.025588e-05 -1.752082e-05 -1.434621e-05 ......
## ASV0469     -1.464729e-03 -1.527289e-03 -1.592233e-03 -1.659629e-03 ......
## ASV0471      1.011251e-03  1.058242e-03  1.107308e-03  1.158528e-03 ......
## ASV0451     -2.817063e-04 -2.958710e-04 -3.107709e-04 -3.264451e-04 ......
## ASV0747      4.103118e-04  4.307555e-04  4.522147e-04  4.747369e-04 ......
## ASV1314     -6.009734e-04 -6.301209e-04 -6.606930e-04 -6.927595e-04 ......
## ASV0425     -1.620975e-03 -1.687821e-03 -1.757018e-03 -1.828618e-03 ......
## ASV0559     -9.285911e-04 -9.671652e-04 -1.007132e-03 -1.048527e-03 ......
## ASV0148     -9.812083e-04 -1.020534e-03 -1.061133e-03 -1.103022e-03 ......
## ASV0129     -4.446521e-04 -4.599150e-04 -4.754512e-04 -4.912434e-04 ......
## ASV1072      4.532622e-04  4.705558e-04  4.883542e-04  5.066612e-04 ......
## ASV2390      3.524935e-04  3.670520e-04  3.821138e-04  3.976878e-04 ......
## ASV0548      1.103318e-03  1.153089e-03  1.205000e-03  1.259135e-03 ......
## ASV0168     -1.605957e-03 -1.674587e-03 -1.745845e-03 -1.819809e-03 ......
## ASV0066     -1.225842e-03 -1.279899e-03 -1.336156e-03 -1.394690e-03 ......
## ASV0468     -4.487627e-04 -4.684770e-04 -4.889859e-04 -5.103157e-04 ......
## ASV0172     -1.942587e-04 -1.990117e-04 -2.036510e-04 -2.081492e-04 ......
## ASV0236     -5.415054e-04 -5.597789e-04 -5.783433e-04 -5.971737e-04 ......
## ASV0250      1.344271e-04  1.466666e-04  1.599241e-04  1.742754e-04 ......
## ASV0338     -2.397307e-05 -2.128190e-05 -1.818953e-05 -1.466175e-05 ......
## ASV0450     -1.130031e-05 -1.204462e-05 -1.284224e-05 -1.369720e-05 ......
## ASV0377      1.346259e-03  1.405957e-03  1.468118e-03  1.532830e-03 ......
## ASV1022      3.819882e-04  3.994099e-04  4.175982e-04  4.365850e-04 ......
## ASV6174     -8.729707e-05 -9.086323e-05 -9.455673e-05 -9.838132e-05 ......
## ASV0786      1.355223e-04  1.405233e-04  1.456453e-04  1.508856e-04 ......
## ASV0053     -1.642336e-03 -1.716275e-03 -1.793352e-03 -1.873686e-03 ......
## ASV0697     -4.444183e-04 -4.624069e-04 -4.810037e-04 -5.002211e-04 ......
## ASV0785      1.191870e-03  1.244617e-03  1.299563e-03  1.356790e-03 ......
## ASV1967     -7.621832e-04 -7.936593e-04 -8.262487e-04 -8.599770e-04 ......
## ASV0385     -3.278160e-04 -3.401709e-04 -3.528863e-04 -3.659668e-04 ......
## ASV0295      4.288084e-05  4.775479e-05  5.309250e-05  5.893301e-05 ......
## ASV0072     -1.231222e-03 -1.282207e-03 -1.335008e-03 -1.389667e-03 ......
## ASV0157     -4.933889e-04 -5.120995e-04 -5.312905e-04 -5.509518e-04 ......
## ASV0501      6.404009e-04  6.712173e-04  7.034618e-04  7.371920e-04 ......
## ASV10729    -1.007639e-03 -1.053591e-03 -1.101546e-03 -1.151584e-03 ......
## ASV1470      3.799507e-04  3.931324e-04  4.065825e-04  4.202910e-04 ......
## ASV0050     -3.176949e-03 -3.314779e-03 -3.458057e-03 -3.606959e-03 ......
## ASV0411     -6.108216e-05 -6.257548e-05 -6.404896e-05 -6.549755e-05 ......
## ASV0549      6.356264e-04  6.659038e-04  6.976375e-04  7.308990e-04 ......
## ASV0184      3.819197e-04  3.991239e-04  4.170705e-04  4.357897e-04 ......
## ASV0705      4.821223e-04  5.050155e-04  5.289756e-04  5.540493e-04 ......
## ASV1715      1.151275e-03  1.202747e-03  1.256380e-03  1.312254e-03 ......
## ASV0603      1.481861e-04  1.555458e-04  1.632855e-04  1.714262e-04 ......
## ASV0826      3.527704e-04  3.666139e-04  3.808795e-04  3.955703e-04 ......
## ASV0034     -1.419544e-03 -1.479644e-03 -1.541967e-03 -1.606568e-03 ......
## ASV0838      3.219140e-04  3.364836e-04  3.516659e-04  3.674819e-04 ......
## ASV0614     -8.203288e-04 -8.559004e-04 -8.928738e-04 -9.312936e-04 ......
## ASV0014     -3.096407e-03 -3.231599e-03 -3.372210e-03 -3.518421e-03 ......
## ASV0585     -1.709841e-04 -1.776705e-04 -1.845634e-04 -1.916646e-04 ......
## ASV0016     -3.167923e-03 -3.306404e-03 -3.450450e-03 -3.600248e-03 ......
## ASV5394     -8.240556e-04 -8.612978e-04 -9.001328e-04 -9.406210e-04 ......
## ASV0666      6.790468e-04  7.084078e-04  7.389113e-04  7.705912e-04 ......
## ASV2085      2.191473e-04  2.252805e-04  2.313684e-04  2.373861e-04 ......
## ASV0003     -2.887685e-03 -3.013268e-03 -3.143846e-03 -3.279582e-03 ......
## ASV0346      3.123576e-06  7.070010e-06  1.149403e-05  1.643709e-05 ......
## ASV0267     -4.480861e-04 -4.662031e-04 -4.848995e-04 -5.041803e-04 ......
## ASV0353      7.238154e-04  7.610464e-04  8.002130e-04  8.414124e-04 ......
## ASV2419      8.038563e-04  8.380496e-04  8.735305e-04  9.103346e-04 ......
## ASV0447      4.432650e-04  4.665303e-04  4.910505e-04  5.168918e-04 ......
## ASV0654      1.304716e-03  1.364142e-03  1.426143e-03  1.490816e-03 ......
## ASV0151      2.301072e-04  2.427754e-04  2.561947e-04  2.704126e-04 ......
## ASV0065     -1.146277e-03 -1.195442e-03 -1.246503e-03 -1.299518e-03 ......
## ASV0527      8.548934e-04  8.926509e-04  9.319537e-04  9.728551e-04 ......
## ASV4055     -3.496237e-04 -3.669747e-04 -3.852125e-04 -4.043843e-04 ......
## ASV0166     -8.886963e-04 -9.234538e-04 -9.592881e-04 -9.962120e-04 ......
## ASV0417     -8.123261e-04 -8.470411e-04 -8.830763e-04 -9.204691e-04 ......
## ASV0078     -6.170441e-04 -6.416786e-04 -6.671054e-04 -6.933345e-04 ......
## ASV0322     -7.295148e-04 -7.579870e-04 -7.873438e-04 -8.175967e-04 ......
## ASV0156     -9.734281e-04 -1.012944e-03 -1.053823e-03 -1.096097e-03 ......
## ASV0648     -9.813319e-04 -1.026655e-03 -1.074005e-03 -1.123467e-03 ......
## ASV0407      6.848693e-05  7.202054e-05  7.576656e-05  7.974037e-05 ......
## ASV2030     -1.876907e-04 -1.949658e-04 -2.024707e-04 -2.102105e-04 ......
## ASV0300      6.263472e-04  6.577950e-04  6.908255e-04  7.255148e-04 ......
## ASV1150     -6.201019e-05 -6.389471e-05 -6.578085e-05 -6.766232e-05 ......
## ASV0958      6.209394e-04  6.513741e-04  6.833264e-04  7.168733e-04 ......
## ASV0216     -9.643908e-04 -1.004483e-03 -1.046015e-03 -1.089023e-03 ......
## ASV0446      1.477324e-03  1.547664e-03  1.621294e-03  1.698356e-03 ......
## ASV0367     -4.803446e-04 -5.016672e-04 -5.238764e-04 -5.470046e-04 ......
## ASV0200     -8.730222e-04 -9.112187e-04 -9.509663e-04 -9.923200e-04 ......
## ASV0334     -3.891958e-04 -4.017314e-04 -4.143906e-04 -4.271471e-04 ......
## ASV1311      6.292467e-04  6.568815e-04  6.856339e-04  7.155411e-04 ......
## ASV0458      6.644068e-04  6.930480e-04  7.228051e-04  7.537126e-04 ......
## ASV1371      2.231496e-05  2.342549e-05  2.459001e-05  2.581067e-05 ......
## ASV0418      7.632383e-04  7.945437e-04  8.269473e-04  8.604738e-04 ......
## ASV0004      9.596756e-04  1.001029e-03  1.043985e-03  1.088593e-03 ......
## ASV1943      6.931501e-04  7.223603e-04  7.526585e-04  7.840749e-04 ......
## ASV1495     -2.348561e-04 -2.486767e-04 -2.633586e-04 -2.789560e-04 ......
## ASV0901     -1.154431e-03 -1.207941e-03 -1.263868e-03 -1.322314e-03 ......
## ASV0628      6.381355e-04  6.650615e-04  6.929706e-04  7.218857e-04 ......
## ASV0400      2.715345e-04  2.835727e-04  2.960920e-04  3.091063e-04 ......
## ASV0116     -8.693942e-04 -9.092524e-04 -9.508716e-04 -9.943238e-04 ......
## ASV0788      7.110571e-04  7.426229e-04  7.754935e-04  8.097151e-04 ......
## ASV0117      4.833063e-04  5.067058e-04  5.312477e-04  5.569876e-04 ......
## ASV3137      1.318128e-04  1.379082e-04  1.442817e-04  1.509460e-04 ......
## ASV0001      1.128472e-03  1.175266e-03  1.223736e-03  1.273921e-03 ......
## ASV1651      7.283303e-04  7.574047e-04  7.874201e-04  8.183902e-04 ......
## ASV1692      8.725298e-04  9.135131e-04  9.563846e-04  1.001227e-03 ......
## ASV0660      4.490970e-04  4.663146e-04  4.839834e-04  5.020944e-04 ......
## ASV0508      3.962814e-05  4.027044e-05  4.085464e-05  4.137313e-05 ......
## ASV1660     -3.697806e-04 -3.877590e-04 -4.066056e-04 -4.263603e-04 ......
## ASV0233      1.905868e-04  1.994225e-04  2.086664e-04  2.183375e-04 ......
## ASV1343     -8.643418e-04 -9.037639e-04 -9.449104e-04 -9.878507e-04 ......
## ASV0209      7.610447e-04  7.928988e-04  8.259154e-04  8.601243e-04 ......
## ASV0193     -9.252415e-04 -9.619360e-04 -9.998228e-04 -1.038923e-03 ......
## ASV0357     -4.598410e-05 -4.656177e-05 -4.703271e-05 -4.738173e-05 ......
## ASV0198      2.418401e-04  2.535264e-04  2.657646e-04  2.785789e-04 ......
## ASV0007      1.069787e-03  1.114163e-03  1.160129e-03  1.207724e-03 ......
## ASV1772     -1.032949e-04 -1.071995e-04 -1.111968e-04 -1.152829e-04 ......
## ASV0009      1.006270e-03  1.047818e-03  1.090839e-03  1.135367e-03 ......
## ASV0006      3.858866e-04  4.003303e-04  4.151606e-04  4.303762e-04 ......
## ASV0011     -1.208921e-03 -1.264137e-03 -1.321760e-03 -1.381882e-03 ......
## ASV0015      8.061862e-04  8.409060e-04  8.769656e-04  9.144039e-04 ......
## ASV0017      8.516200e-04  8.881772e-04  9.261379e-04  9.655429e-04 ......
## ASV0235     -7.161578e-04 -7.491042e-04 -7.834932e-04 -8.193803e-04 ......
## ASV0382      1.821805e-04  1.936112e-04  2.057664e-04  2.186882e-04 ......
## ASV2357      1.066921e-03  1.115247e-03  1.165659e-03  1.218238e-03 ......
## ASV0567     -7.383343e-04 -7.698854e-04 -8.026594e-04 -8.366956e-04 ......
## ASV0165      8.588680e-04  8.979123e-04  9.386454e-04  9.811326e-04 ......
## ASV0005      1.645147e-03  1.715892e-03  1.789375e-03  1.865679e-03 ......
## ASV0384     -4.441751e-05 -4.398689e-05 -4.331740e-05 -4.238036e-05 ......
## ASV0002      3.638810e-04  3.806769e-04  3.982193e-04  4.165388e-04 ......
## ASV3017      9.530551e-04  9.934711e-04  1.035403e-03  1.078894e-03 ......
## ASV0091      3.912486e-04  4.095496e-04  4.286873e-04  4.486977e-04 ......
## ASV0186     -1.022362e-03 -1.068391e-03 -1.116371e-03 -1.166373e-03 ......
## ASV0370      1.292806e-04  1.364239e-04  1.439890e-04  1.520019e-04 ......
## ASV0018      1.718627e-03  1.792904e-03  1.870090e-03  1.950276e-03 ......
## ASV1377      1.498823e-03  1.563064e-03  1.629756e-03  1.698967e-03 ......
## ASV0019      1.722181e-03  1.796683e-03  1.874110e-03  1.954553e-03 ......
## ASV0023      8.498683e-05  8.621129e-05  8.728699e-05  8.819441e-05 ......
## ASV2194      5.447280e-04  5.685649e-04  5.933886e-04  6.192368e-04 ......
## ASV1155     -4.853672e-05 -4.942103e-05 -5.022957e-05 -5.095011e-05 ......
## ASV0510     -5.702422e-04 -5.914293e-04 -6.131811e-04 -6.354969e-04 ......
## ASV2371     -5.801608e-04 -6.028095e-04 -6.261454e-04 -6.501746e-04 ......
## ASV0024      2.034959e-07 -2.365256e-06 -5.242220e-06 -8.452778e-06 ......
## ASV2452      7.828023e-04  8.149839e-04  8.482842e-04  8.827259e-04 ......
## ASV2332      5.359826e-05  5.789042e-05  6.253815e-05  6.756948e-05 ......
## ASV2591      8.646191e-05  9.333718e-05  1.007355e-04  1.086924e-04 ......
## ASV0521      1.176638e-03  1.231808e-03  1.289498e-03  1.349817e-03 ......
## ASV5542      3.744884e-04  3.926214e-04  4.116160e-04  4.315099e-04 ......
## ASV0336     -4.706072e-04 -4.893537e-04 -5.087293e-04 -5.287482e-04 ......
## ASV10102     8.088615e-04  8.463201e-04  8.854549e-04  9.263349e-04 ......
## ASV16823    -5.649020e-04 -5.869994e-04 -6.097767e-04 -6.332416e-04 ......
## ASV3104      5.647839e-04  5.868721e-04  6.096397e-04  6.330940e-04 ......
## ASV0781      3.057619e-04  3.195683e-04  3.339634e-04  3.489693e-04 ......
## ASV10899     3.290601e-04  3.464753e-04  3.648408e-04  3.842079e-04 ......
## ASV11222    -5.647219e-04 -5.868065e-04 -6.095704e-04 -6.330210e-04 ......
## ASV11327    -5.646039e-04 -5.866793e-04 -6.094334e-04 -6.328735e-04 ......
## ASV12458    -5.644859e-04 -5.865522e-04 -6.092964e-04 -6.327262e-04 ......
## ASV1636     -4.616069e-04 -4.795698e-04 -4.980739e-04 -5.171237e-04 ......
## ASV1890     -5.723899e-04 -5.954697e-04 -6.193276e-04 -6.439794e-04 ......
## ASV2898      1.296610e-03  1.352277e-03  1.410079e-03  1.470079e-03 ......
## ASV8328     -4.282319e-05 -4.099778e-05 -3.879086e-05 -3.616532e-05 ......
## ASV0709     -1.067452e-03 -1.113717e-03 -1.161792e-03 -1.211731e-03 ......
## ASV0856      1.951427e-04  2.051857e-04  2.157589e-04  2.268900e-04 ......
## ASV0909     -3.932466e-04 -4.065603e-04 -4.200824e-04 -4.337940e-04 ......
## ASV0937     -8.418779e-04 -8.794475e-04 -9.186004e-04 -9.593969e-04 ......
## ASV11390    -5.642496e-04 -5.862984e-04 -6.090243e-04 -6.324346e-04 ......
## ASV11966     3.438312e-04  3.609962e-04  3.790220e-04  3.979501e-04 ......
## ASV12990     1.809588e-04  1.895825e-04  1.985997e-04  2.080257e-04 ......
## ASV14797     6.225233e-04  6.489552e-04  6.763715e-04  7.047975e-04 ......
## ASV14904    -5.642393e-04 -5.862888e-04 -6.090156e-04 -6.324271e-04 ......
## ASV15304     2.028776e-04  2.141686e-04  2.261072e-04  2.387293e-04 ......
## ASV16696    -5.641556e-04 -5.861996e-04 -6.089205e-04 -6.323259e-04 ......
## ASV1690      3.544112e-04  3.723934e-04  3.912890e-04  4.111415e-04 ......
## ASV2029      1.670577e-03  1.742937e-03  1.818133e-03  1.896249e-03 ......
## ASV2834      9.116492e-04  9.522957e-04  9.946400e-04  1.038743e-03 ......
## ASV4003      3.130287e-04  3.302403e-04  3.484371e-04  3.676753e-04 ......
## ASV4064      6.322032e-04  6.604062e-04  6.897789e-04  7.203617e-04 ......
## ASV4294      2.702858e-04  2.853279e-04  3.012525e-04  3.181123e-04 ......
## ASV4609     -1.467525e-05 -1.462723e-05 -1.452289e-05 -1.435635e-05 ......
## ASV6283     -5.641959e-04 -5.862470e-04 -6.089763e-04 -6.323911e-04 ......
## ASV6491     -5.640780e-04 -5.861200e-04 -6.088395e-04 -6.322439e-04 ......
## ASV7453      2.840103e-04  2.991571e-04  3.151315e-04  3.319771e-04 ......
## ASV7959      8.906652e-05  9.553546e-05  1.024695e-04  1.098990e-04 ......
## ASV8219      5.640232e-04  5.860629e-04  6.087802e-04  6.321826e-04 ......
## ASV8547     -5.639054e-04 -5.859360e-04 -6.086435e-04 -6.320354e-04 ......
## ASV9319      4.397270e-04  4.606087e-04  4.824618e-04  5.053286e-04 ......
## ASV9382     -5.638476e-04 -5.858746e-04 -6.085784e-04 -6.319666e-04 ......
## ASV11516    -5.637298e-04 -5.857477e-04 -6.084417e-04 -6.318196e-04 ......
## ASV14377    -5.636122e-04 -5.856209e-04 -6.083052e-04 -6.316726e-04 ......
## ASV1867      9.200794e-04  9.622388e-04  1.006253e-03  1.052197e-03 ......
## ASV1895     -1.877272e-04 -1.948529e-04 -2.021868e-04 -2.097314e-04 ......
## ASV3168      3.799732e-04  3.962757e-04  4.131877e-04  4.307235e-04 ......
## ASV4449      7.220998e-04  7.516702e-04  7.822747e-04  8.139374e-04 ......
## ASV6596      4.882360e-04  5.130246e-04  5.391083e-04  5.665556e-04 ......
## ASV7492     -1.764967e-04 -1.811254e-04 -1.856930e-04 -1.901793e-04 ......
## ASV9854     -2.766555e-04 -2.867061e-04 -2.970035e-04 -3.075453e-04 ......
## ASV6296      5.634003e-04  5.853949e-04  6.080645e-04  6.314166e-04 ......
## ASV4201      2.616373e-04  2.770194e-04  2.933449e-04  3.106706e-04 ......
## ASV0552      1.556383e-03  1.628318e-03  1.703457e-03  1.781929e-03 ......
## ASV3671     -8.219469e-05 -8.329437e-05 -8.424354e-05 -8.502362e-05 ......
## ASV3529     -8.407430e-05 -8.475851e-05 -8.523666e-05 -8.548551e-05 ......
## ASV1060      3.818084e-04  3.991605e-04  4.172685e-04  4.361627e-04 ......
## ASV0239     -8.017541e-04 -8.336198e-04 -8.664791e-04 -9.003404e-04 ......
## ASV5711     -7.454255e-04 -7.759587e-04 -8.075592e-04 -8.402516e-04 ......
## ASV4152     -1.000754e-03 -1.042952e-03 -1.086719e-03 -1.132099e-03 ......
## ASV1461      8.901376e-04  9.268003e-04  9.647323e-04  1.003958e-03 ......
## ASV2877      7.372780e-04  7.687263e-04  8.013561e-04  8.351986e-04 ......
## ASV0012      5.788903e-04  6.055764e-04  6.334435e-04  6.625390e-04 ......
## ASV9823      1.325805e-04  1.357228e-04  1.388217e-04  1.418674e-04 ......
## ASV0008      6.266480e-04  6.551726e-04  6.849329e-04  7.159766e-04 ......
## ASV7832     -6.176042e-04 -6.436152e-04 -6.705991e-04 -6.985839e-04 ......
## ASV1915      7.662699e-05  8.147497e-05  8.662961e-05  9.210817e-05 ......
## ASV0055      4.257558e-04  4.437777e-04  4.624589e-04  4.818145e-04 ......
## ASV0032      1.050257e-03  1.095413e-03  1.142319e-03  1.191028e-03 ......
## ASV2977     -8.350756e-04 -8.698901e-04 -9.059614e-04 -9.433203e-04 ......
## ASV0466      8.306606e-04  8.641073e-04  8.986532e-04  9.343149e-04 ......
## ASV3866      9.509523e-04  9.940680e-04  1.039039e-03  1.085936e-03 ......
## ASV0040      1.259424e-03  1.316613e-03  1.376267e-03  1.438480e-03 ......
## ASV0496     -1.173897e-04 -1.257433e-04 -1.347114e-04 -1.443379e-04 ......
## ASV0052      1.505815e-03  1.571672e-03  1.640165e-03  1.711379e-03 ......
## ASV3828     -9.073155e-04 -9.460549e-04 -9.862914e-04 -1.028073e-03 ......
## ASV1930      5.972107e-04  6.242422e-04  6.524177e-04  6.817777e-04 ......
## ASV2126      9.376218e-04  9.785744e-04  1.021158e-03  1.065424e-03 ......
## ASV0793      5.951473e-04  6.235601e-04  6.533052e-04  6.844406e-04 ......
## ASV0299     -3.686763e-04 -3.828193e-04 -3.973668e-04 -4.123199e-04 ......
## ASV0208      9.403839e-04  9.852835e-04  1.032299e-03  1.081527e-03 ......
## ASV0511     -4.398670e-04 -4.563630e-04 -4.732863e-04 -4.906320e-04 ......
## ASV1123     -5.893923e-04 -6.126953e-04 -6.367298e-04 -6.615045e-04 ......
## ASV0099     -3.114945e-04 -3.235213e-04 -3.358911e-04 -3.486027e-04 ......
## ASV0752     -1.020163e-04 -1.082562e-04 -1.148905e-04 -1.219430e-04 ......
## ASV0883      2.167949e-05  2.342753e-05  2.531000e-05  2.733614e-05 ......
## ASV0683      8.233414e-04  8.620324e-04  9.025017e-04  9.448260e-04 ......
## ASV4117     -9.049614e-04 -9.431874e-04 -9.828449e-04 -1.023974e-03 ......
## ASV2172      3.542712e-04  3.701801e-04  3.867596e-04  4.040342e-04 ......
## ASV0330     -6.207062e-04 -6.479159e-04 -6.762368e-04 -7.057084e-04 ......
## ASV0728      6.186377e-04  6.471679e-04  6.769527e-04  7.080404e-04 ......
## ASV0499      1.245259e-03  1.304096e-03  1.365685e-03  1.430151e-03 ......
## ASV0120     -1.318490e-03 -1.376559e-03 -1.436972e-03 -1.499805e-03 ......
## ASV1446      7.347583e-05  7.443187e-05  7.523378e-05  7.586052e-05 ......
## ASV17171    -8.661590e-04 -9.031509e-04 -9.415633e-04 -9.814397e-04 ......
## ASV0533      2.735018e-04  2.869101e-04  3.009831e-04  3.157536e-04 ......
## ASV2495     -3.736345e-04 -3.911758e-04 -4.095447e-04 -4.287817e-04 ......
## ASV5582      2.840657e-04  2.946790e-04  3.055646e-04  3.167189e-04 ......
## ASV1488      3.708911e-04  3.903242e-04  4.107403e-04  4.321814e-04 ......
## ASV0682      8.791036e-04  9.211375e-04  9.651779e-04  1.011319e-03 ......
## ASV0068     -6.302111e-05 -6.698168e-05 -7.119068e-05 -7.566185e-05 ......
## ASV1987     -4.982490e-04 -5.234190e-04 -5.498876e-04 -5.777217e-04 ......
## ASV0035      1.211029e-04  1.236085e-04  1.259611e-04  1.281327e-04 ......
## ASV7192     -5.608947e-04 -5.832926e-04 -6.064107e-04 -6.302584e-04 ......
## ASV0873      6.225764e-05  6.334767e-05  6.435652e-05  6.527306e-05 ......
## ASV4749      7.939764e-06  5.194723e-06  2.065301e-06 -1.485049e-06 ......
## ASV2174      4.787318e-04  4.960004e-04  5.137226e-04  5.319018e-04 ......
## ASV1476     -4.839895e-04 -5.051421e-04 -5.271585e-04 -5.500703e-04 ......
## ASV0740     -1.244270e-03 -1.302016e-03 -1.362359e-03 -1.425410e-03 ......
## ASV0170      2.522327e-04  2.632954e-04  2.748105e-04  2.867943e-04 ......
## ASV2466     -1.085727e-03 -1.133432e-03 -1.183087e-03 -1.234761e-03 ......
## ASV1709      8.230439e-04  8.580005e-04  8.942751e-04  9.319047e-04 ......
## ASV6170     -6.288626e-04 -6.521144e-04 -6.760525e-04 -7.006902e-04 ......
## ASV3673      8.046571e-04  8.378205e-04  8.722103e-04  9.078647e-04 ......
## ASV1745      1.220818e-05  1.108384e-05  9.821305e-06  8.412771e-06 ......
## ASV0380     -4.685110e-04 -4.840546e-04 -4.999146e-04 -5.160870e-04 ......
## ASV0426     -1.502164e-04 -1.551692e-04 -1.602009e-04 -1.653051e-04 ......
## ASV0202     -1.139871e-04 -1.142930e-04 -1.142097e-04 -1.136912e-04 ......
## ASV6350     -6.267398e-04 -6.500025e-04 -6.739627e-04 -6.986351e-04 ......
## ASV0713     -5.314197e-04 -5.553115e-04 -5.802222e-04 -6.061909e-04 ......
## ASV1822      1.418372e-04  1.497566e-04  1.581141e-04  1.669320e-04 ......
## ASV4569      8.065501e-04  8.407849e-04  8.763465e-04  9.132787e-04 ......
## ASV0030     -2.155757e-04 -2.264493e-04 -2.378484e-04 -2.497935e-04 ......
## ASV0331      3.802889e-04  3.995144e-04  4.197355e-04  4.410046e-04 ......
## ASV2981      8.932884e-04  9.350835e-04  9.787546e-04  1.024377e-03 ......
## ASV0828     -6.084008e-04 -6.377525e-04 -6.685000e-04 -7.007063e-04 ......
## ASV2440      1.386010e-03  1.450229e-03  1.517315e-03  1.587386e-03 ......
## ASV3006     -4.796213e-04 -4.958411e-04 -5.124248e-04 -5.293717e-04 ......
## ASV3875     -4.795392e-04 -4.957536e-04 -5.123317e-04 -5.292727e-04 ......
## ASV4511      3.545874e-04  3.716886e-04  3.896157e-04  4.084080e-04 ......
## ASV4700     -4.794580e-04 -4.956672e-04 -5.122397e-04 -5.291749e-04 ......
## ASV5804     -4.793759e-04 -4.955798e-04 -5.121466e-04 -5.290759e-04 ......
## ASV6826      6.487121e-04  6.794315e-04  7.115838e-04  7.452328e-04 ......
## ASV7280      5.859829e-04  6.148402e-04  6.450760e-04  6.767487e-04 ......
## ASV7535     -4.793627e-04 -4.955675e-04 -5.121355e-04 -5.290663e-04 ......
## ASV0651     -5.712877e-04 -5.942791e-04 -6.180063e-04 -6.424765e-04 ......
## ASV0913      8.355312e-04  8.744460e-04  9.151356e-04  9.576779e-04 ......
## ASV10832    -4.792862e-04 -4.954861e-04 -5.120490e-04 -5.289745e-04 ......
## ASV1117     -1.119285e-03 -1.166933e-03 -1.216419e-03 -1.267800e-03 ......
## ASV11329     3.675909e-04  3.886895e-04  4.110184e-04  4.346467e-04 ......
## ASV13209     4.908884e-05  5.523018e-05  6.185796e-05  6.899829e-05 ......
## ASV1345      1.954484e-04  2.059398e-04  2.169539e-04  2.285099e-04 ......
## ASV1719     -4.791911e-04 -4.953869e-04 -5.119458e-04 -5.288672e-04 ......
## ASV1886      6.312203e-04  6.578940e-04  6.856126e-04  7.144141e-04 ......
## ASV2158     -6.438788e-05 -6.308316e-05 -6.148287e-05 -5.956753e-05 ......
## ASV2189      7.063635e-04  7.375635e-04  7.700547e-04  8.038840e-04 ......
## ASV2257      5.109780e-04  5.329780e-04  5.558763e-04  5.797080e-04 ......
## ASV2283      4.790007e-04  4.951832e-04  5.117280e-04  5.286345e-04 ......
## ASV2328      4.789187e-04  4.950959e-04  5.116351e-04  5.285357e-04 ......
## ASV2434     -8.014536e-04 -8.342322e-04 -8.682257e-04 -9.034746e-04 ......
## ASV2648      4.787138e-04  4.948758e-04  5.113988e-04  5.282822e-04 ......
## ASV2698      8.439164e-04  8.821701e-04  9.220936e-04  9.637554e-04 ......
## ASV2775      9.264532e-04  9.629447e-04  1.000614e-03  1.039481e-03 ......
## ASV3171      4.785183e-04  4.946661e-04  5.111741e-04  5.280415e-04 ......
## ASV3227      6.793172e-04  7.054972e-04  7.324689e-04  7.602416e-04 ......
## ASV3397      9.002833e-05  9.541562e-05  1.010854e-04  1.070468e-04 ......
## ASV3444      7.594285e-04  7.896255e-04  8.208816e-04  8.532291e-04 ......
## ASV3556      4.782830e-04  4.944138e-04  5.109038e-04  5.277522e-04 ......
## ASV3606     -4.782013e-04 -4.943268e-04 -5.108113e-04 -5.276538e-04 ......
## ASV4190      7.438474e-04  7.774943e-04  8.126144e-04  8.492694e-04 ......
## ASV4197      7.879276e-04  8.191997e-04  8.515279e-04  8.849372e-04 ......
## ASV4722      7.525214e-04  7.850741e-04  8.189279e-04  8.541277e-04 ......
## ASV4765      2.250331e-04  2.359995e-04  2.474456e-04  2.593857e-04 ......
## ASV4809      4.779681e-04  4.940765e-04  5.105426e-04  5.273657e-04 ......
## ASV4846      5.616777e-04  5.872054e-04  6.138138e-04  6.415405e-04 ......
## ASV4903     -6.563811e-05 -6.444566e-05 -6.296307e-05 -6.117052e-05 ......
## ASV4944     -4.779128e-04 -4.940192e-04 -5.104834e-04 -5.273046e-04 ......
## ASV5151     -3.050204e-04 -3.228834e-04 -3.417909e-04 -3.617994e-04 ......
## ASV5413     -4.778789e-04 -4.939849e-04 -5.104489e-04 -5.272701e-04 ......
## ASV5537     -4.777974e-04 -4.938980e-04 -5.103565e-04 -5.271719e-04 ......
## ASV5688      4.777158e-04  4.938112e-04  5.102641e-04  5.270736e-04 ......
## ASV5752      3.342461e-04  3.512780e-04  3.691300e-04  3.878337e-04 ......
## ASV6122     -4.776738e-04 -4.937676e-04 -5.102188e-04 -5.270268e-04 ......
## ASV6135      4.775923e-04  4.936808e-04  5.101264e-04  5.269286e-04 ......
## ASV6188     -4.775108e-04 -4.935940e-04 -5.100341e-04 -5.268304e-04 ......
## ASV6216      7.855113e-04  8.166656e-04  8.488768e-04  8.821710e-04 ......
## ASV6242      4.773172e-04  4.933864e-04  5.098118e-04  5.265925e-04 ......
## ASV6383      4.772358e-04  4.932998e-04  5.097196e-04  5.264944e-04 ......
## ASV6781      4.771544e-04  4.932131e-04  5.096274e-04  5.263964e-04 ......
## ASV6799     -4.770731e-04 -4.931265e-04 -5.095352e-04 -5.262984e-04 ......
## ASV7374     -4.769918e-04 -4.930399e-04 -5.094431e-04 -5.262005e-04 ......
## ASV7539     -4.769105e-04 -4.929533e-04 -5.093510e-04 -5.261026e-04 ......
## ASV8591     -4.768292e-04 -4.928668e-04 -5.092589e-04 -5.260047e-04 ......
## ASV8637      4.767480e-04  4.927803e-04  5.091669e-04  5.259069e-04 ......
## ASV12796    -4.766668e-04 -4.926938e-04 -5.090749e-04 -5.258091e-04 ......
## ASV1934      6.755000e-04  7.060188e-04  7.378475e-04  7.710362e-04 ......
## ASV22549     1.188887e-04  1.281979e-04  1.381396e-04  1.487473e-04 ......
## ASV29857    -4.766105e-04 -4.926353e-04 -5.090142e-04 -5.257462e-04 ......
## ASV3215      8.437708e-04  8.833905e-04  9.248506e-04  9.682349e-04 ......
## ASV3236     -4.765210e-04 -4.925398e-04 -5.089123e-04 -5.256377e-04 ......
## ASV3954     -4.764398e-04 -4.924534e-04 -5.088204e-04 -5.255400e-04 ......
## ASV4850      4.763587e-04  4.923670e-04  5.087285e-04  5.254423e-04 ......
## ASV5225      4.762776e-04  4.922807e-04  5.086366e-04  5.253447e-04 ......
## ASV5532     -4.761966e-04 -4.921943e-04 -5.085448e-04 -5.252470e-04 ......
## ASV7258      1.668217e-04  1.796097e-04  1.933049e-04  2.079636e-04 ......
## ASV9474     -2.241722e-04 -2.289565e-04 -2.336207e-04 -2.381456e-04 ......
## ASV11857    -4.761346e-04 -4.921316e-04 -5.084817e-04 -5.251840e-04 ......
## ASV1202     -4.760535e-04 -4.920453e-04 -5.083899e-04 -5.250864e-04 ......
## ASV14742     4.748141e-04  4.996018e-04  5.256955e-04  5.531617e-04 ......
## ASV16652     2.471865e-04  2.594782e-04  2.723185e-04  2.857236e-04 ......
## ASV2019      7.934601e-04  8.257790e-04  8.592509e-04  8.939071e-04 ......
## ASV2410     -7.825321e-04 -8.171697e-04 -8.532749e-04 -8.909065e-04 ......
## ASV2718      8.892516e-04  9.314563e-04  9.755960e-04  1.021750e-03 ......
## ASV2738      8.744172e-04  9.084264e-04  9.434979e-04  9.796475e-04 ......
## ASV2876      4.758780e-04  4.918587e-04  5.081918e-04  5.248763e-04 ......
## ASV3177      4.757970e-04  4.917725e-04  5.081001e-04  5.247788e-04 ......
## ASV4367      4.757161e-04  4.916864e-04  5.080084e-04  5.246814e-04 ......
## ASV4635      2.833434e-04  3.002020e-04  3.180205e-04  3.368444e-04 ......
## ASV4896      1.485846e-04  1.608301e-04  1.739843e-04  1.881058e-04 ......
## ASV4907      5.111116e-04  5.383788e-04  5.670968e-04  5.973374e-04 ......
## ASV5230     -4.758123e-04 -4.917957e-04 -5.081324e-04 -5.248216e-04 ......
## ASV6509     -4.757314e-04 -4.917095e-04 -5.080407e-04 -5.247241e-04 ......
## ASV7376     -4.756504e-04 -4.916233e-04 -5.079490e-04 -5.246266e-04 ......
## ASV8163     -4.755695e-04 -4.915372e-04 -5.078573e-04 -5.245292e-04 ......
## ASV8195     -4.754886e-04 -4.914510e-04 -5.077657e-04 -5.244318e-04 ......
## ASV8923      4.063414e-04  4.269656e-04  4.486068e-04  4.713089e-04 ......
## ASV9666     -4.070391e-04 -4.198091e-04 -4.327849e-04 -4.459591e-04 ......
## ASV1482      5.625097e-04  5.890068e-04  6.167051e-04  6.456534e-04 ......
## ASV2726      7.361895e-04  7.712186e-04  8.078549e-04  8.461640e-04 ......
## ASV3281     -4.754489e-04 -4.914118e-04 -5.077274e-04 -5.243949e-04 ......
## ASV4235     -4.753680e-04 -4.913257e-04 -5.076358e-04 -5.242975e-04 ......
## ASV4808      8.012588e-04  8.338463e-04  8.676137e-04  9.025967e-04 ......
## ASV4861     -7.990289e-04 -8.316536e-04 -8.654861e-04 -9.005668e-04 ......
## ASV5276      7.884554e-04  8.201547e-04  8.529577e-04  8.868933e-04 ......
## ASV5837      7.429620e-04  7.772537e-04  8.130991e-04  8.505667e-04 ......
## ASV7098      7.533232e-04  7.877487e-04  8.237074e-04  8.612647e-04 ......
## ASV8451     -4.749059e-04 -4.908278e-04 -5.070994e-04 -5.237201e-04 ......
## ASV8694     -4.748253e-04 -4.907419e-04 -5.070081e-04 -5.236230e-04 ......
## ASV0905     -3.214118e-04 -3.356498e-04 -3.504083e-04 -3.656941e-04 ......
## ASV2900      6.127890e-04  6.352268e-04  6.583130e-04  6.820592e-04 ......
## ASV3963     -4.580568e-04 -4.731892e-04 -4.886354e-04 -5.043928e-04 ......
## ASV0041     -6.802146e-04 -7.127326e-04 -7.467580e-04 -7.823536e-04 ......
## ASV1865      7.205346e-04  7.568954e-04  7.950724e-04  8.351504e-04 ......
## ASV1140      5.628053e-04  5.893275e-04  6.170070e-04  6.458832e-04 ......
## ASV1179      7.811023e-04  8.170878e-04  8.546499e-04  8.938486e-04 ......
## ASV0279      1.037595e-03  1.082296e-03  1.128785e-03  1.177128e-03 ......
## ASV0043     -1.431048e-04 -1.528623e-04 -1.633266e-04 -1.745493e-04 ......
## ASV2097     -5.452331e-04 -5.671079e-04 -5.897721e-04 -6.132515e-04 ......
## ASV0309     -2.700727e-04 -2.803841e-04 -2.910019e-04 -3.019297e-04 ......
## ASV0607      1.329800e-03  1.391000e-03  1.454905e-03  1.521623e-03 ......
## ASV0025     -1.417966e-03 -1.483664e-03 -1.552272e-03 -1.623905e-03 ......
## ASV2284     -1.536718e-04 -1.568685e-04 -1.599643e-04 -1.629443e-04 ......
## ASV0556      2.810932e-04  2.963814e-04  3.125071e-04  3.295131e-04 ......
## ASV5040      3.787862e-04  3.902782e-04  4.019210e-04  4.137053e-04 ......
## ASV2924     -4.164209e-04 -4.298096e-04 -4.434485e-04 -4.573337e-04 ......
## ASV1331      1.656698e-03  1.730046e-03  1.806448e-03  1.886018e-03 ......
## ASV0506     -6.907227e-04 -7.172552e-04 -7.445745e-04 -7.726872e-04 ......
## ASV1514      1.249394e-03  1.304706e-03  1.362272e-03  1.422168e-03 ......
## ASV2144      1.038944e-03  1.084518e-03  1.131957e-03  1.181327e-03 ......
## ASV2265      1.394883e-03  1.456824e-03  1.521331e-03  1.588493e-03 ......
## ASV5156      2.422539e-04  2.497495e-04  2.573462e-04  2.650377e-04 ......
## ASV5534      1.749605e-04  1.788831e-04  1.827126e-04  1.864324e-04 ......
## ASV5747     -1.189792e-04 -1.283494e-04 -1.383731e-04 -1.490867e-04 ......
## ASV6657      5.903338e-04  6.143362e-04  6.391887e-04  6.649143e-04 ......
## ASV0658     -6.451531e-04 -6.699776e-04 -6.955499e-04 -7.218785e-04 ......
## ASV0716      1.670377e-04  1.736413e-04  1.804559e-04  1.874850e-04 ......
## ASV1657      2.387386e-04  2.456536e-04  2.526090e-04  2.595932e-04 ......
## ASV1885     -8.382943e-05 -9.133359e-05 -9.939521e-05 -1.080465e-04 ......
## ASV2333      1.490600e-03  1.554207e-03  1.620262e-03  1.688839e-03 ......
## ASV3375      5.129673e-04  5.327180e-04  5.530950e-04  5.741122e-04 ......
## ASV4317      5.998583e-04  6.271102e-04  6.555795e-04  6.853205e-04 ......
## ASV9599     -1.193379e-04 -1.287340e-04 -1.387854e-04 -1.495284e-04 ......
## ASV0175     -1.997443e-03 -2.081750e-03 -2.169166e-03 -2.259771e-03 ......
## ASV1032      5.484178e-04  5.691998e-04  5.905964e-04  6.126150e-04 ......
## ASV1235     -3.031503e-05 -3.440170e-05 -3.884060e-05 -4.365353e-05 ......
## ASV1262      1.778531e-03  1.855172e-03  1.934803e-03  2.017516e-03 ......
## ASV1320      5.070167e-04  5.333812e-04  5.611337e-04  5.903447e-04 ......
## ASV13797     6.354649e-04  6.618470e-04  6.892162e-04  7.176042e-04 ......
## ASV1491      4.095108e-04  4.311530e-04  4.539070e-04  4.778215e-04 ......
## ASV15014    -1.194282e-04 -1.288269e-04 -1.388804e-04 -1.496252e-04 ......
## ASV1510      5.981028e-04  6.271450e-04  6.575333e-04  6.893202e-04 ......
## ASV1551     -2.129690e-04 -2.217017e-04 -2.307404e-04 -2.400922e-04 ......
## ASV1919      3.779478e-05  4.356276e-05  4.983692e-05  5.664871e-05 ......
## ASV2114      2.886364e-04  2.993824e-04  3.104743e-04  3.219246e-04 ......
## ASV21486    -1.192787e-04 -1.286598e-04 -1.386938e-04 -1.494170e-04 ......
## ASV2448      8.791242e-04  9.153018e-04  9.527774e-04  9.915853e-04 ......
## ASV2589      3.980776e-04  4.133511e-04  4.291040e-04  4.453458e-04 ......
## ASV2608      7.119889e-04  7.421242e-04  7.734199e-04  8.059140e-04 ......
## ASV2786      5.806613e-04  6.061130e-04  6.326393e-04  6.602854e-04 ......
## ASV2827      7.533205e-04  7.854035e-04  8.187180e-04  8.533017e-04 ......
## ASV2872      5.689256e-04  5.903984e-04  6.124795e-04  6.351719e-04 ......
## ASV3125      6.909335e-04  7.182462e-04  7.464627e-04  7.756027e-04 ......
## ASV3247      7.589823e-04  7.892737e-04  8.205744e-04  8.529047e-04 ......
## ASV3451     -1.198737e-04 -1.293028e-04 -1.393885e-04 -1.501672e-04 ......
## ASV3465     -1.652117e-04 -1.765699e-04 -1.886722e-04 -2.015605e-04 ......
## ASV3809      4.179456e-04  4.333833e-04  4.492409e-04  4.655203e-04 ......
## ASV4006      9.430433e-04  9.803433e-04  1.018845e-03  1.058568e-03 ......
## ASV4046      6.639790e-04  6.900927e-04  7.170572e-04  7.448895e-04 ......
## ASV4938     -1.247220e-04 -1.343753e-04 -1.446950e-04 -1.557176e-04 ......
## ASV5435     -1.199648e-04 -1.293954e-04 -1.394820e-04 -1.502609e-04 ......
## ASV5605      2.340685e-04  2.408269e-04  2.476201e-04  2.544360e-04 ......
## ASV5635     -1.199473e-04 -1.293737e-04 -1.394555e-04 -1.502289e-04 ......
## ASV5743      8.671771e-04  9.031189e-04  9.403867e-04  9.790201e-04 ......
## ASV6627     -1.200273e-04 -1.294588e-04 -1.395460e-04 -1.503250e-04 ......
## ASV6785     -1.199780e-04 -1.294036e-04 -1.394841e-04 -1.502558e-04 ......
## ASV7368      9.909787e-04  1.035115e-03  1.081125e-03  1.129081e-03 ......
## ASV9118      2.248753e-04  2.318627e-04  2.389573e-04  2.461554e-04 ......
## ASV9135      1.526112e-04  1.556504e-04  1.585716e-04  1.613586e-04 ......
## ASV9435      4.044973e-04  4.178832e-04  4.314931e-04  4.453147e-04 ......
## ASV9671     -1.201107e-04 -1.295437e-04 -1.396318e-04 -1.504113e-04 ......
## ASV0387     -9.354185e-04 -9.722602e-04 -1.010274e-03 -1.049476e-03 ......
## ASV0454     -9.459836e-04 -9.841943e-04 -1.023690e-03 -1.064495e-03 ......
## ASV0751     -5.980173e-04 -6.209024e-04 -6.444613e-04 -6.686996e-04 ......
## ASV1081      2.714291e-04  2.833772e-04  2.957955e-04  3.086976e-04 ......
## ASV1332      5.288961e-04  5.509575e-04  5.738114e-04  5.974768e-04 ......
## ASV2659      8.804866e-04  9.194680e-04  9.600061e-04  1.002147e-03 ......
## ASV2979      8.376396e-04  8.700886e-04  9.035225e-04  9.379521e-04 ......
## ASV4184      2.904679e-04  2.984732e-04  3.064663e-04  3.144268e-04 ......
## ASV6198      2.913902e-04  3.027990e-04  3.146026e-04  3.268140e-04 ......
## ASV7454      5.449953e-04  5.661478e-04  5.879494e-04  6.104083e-04 ......
## ASV8198      1.641491e-04  1.669633e-04  1.695877e-04  1.719982e-04 ......
## ASV0855      1.318050e-03  1.376404e-03  1.437170e-03  1.500434e-03 ......
## ASV10092     5.208517e-04  5.416949e-04  5.632628e-04  5.855755e-04 ......
## ASV1532      7.705003e-04  8.076038e-04  8.464899e-04  8.872422e-04 ......
## ASV2553      1.746322e-03  1.823428e-03  1.903708e-03  1.987273e-03 ......
## ASV2741      7.521576e-04  7.881363e-04  8.257773e-04  8.651485e-04 ......
## ASV4095      4.452055e-04  4.682568e-04  4.924639e-04  5.178760e-04 ......
## ASV5295      4.409886e-04  4.560239e-04  4.713594e-04  4.869859e-04 ......
## ASV5787     -1.204023e-04 -1.298502e-04 -1.399533e-04 -1.507478e-04 ......
## ASV9455      6.397595e-04  6.657411e-04  6.926559e-04  7.205324e-04 ......
## ASV10879     6.880639e-04  7.176608e-04  7.484517e-04  7.804817e-04 ......
## ASV3997      5.266658e-04  5.518196e-04  5.781059e-04  6.055663e-04 ......
## ASV6760      6.313704e-05  6.135200e-05  5.918815e-05  5.661618e-05 ......
## ASV6990      4.655129e-04  4.834695e-04  5.020021e-04  5.211240e-04 ......
## ASV9560      2.725459e-04  2.820723e-04  2.918479e-04  3.018777e-04 ......
## ASV0220      2.943590e-04  3.076438e-04  3.214932e-04  3.359283e-04 ......
## ASV2518      7.016344e-04  7.334647e-04  7.666704e-04  8.013051e-04 ......
## ASV3615      1.054330e-03  1.099534e-03  1.146505e-03  1.195301e-03 ......
## ASV0075      2.351430e-04  2.446106e-04  2.543999e-04  2.645178e-04 ......
## ASV8070      6.299576e-05  6.179750e-05  6.028811e-05  5.844318e-05 ......
## ASV1658      4.801320e-04  4.995526e-04  5.196595e-04  5.404717e-04 ......
## ASV0773      8.033030e-04  8.366968e-04  8.713256e-04  9.072261e-04 ......
## ASV0799      3.352400e-05  3.525816e-05  3.708481e-05  3.900918e-05 ......
## ASV1839     -1.455816e-04 -1.501287e-04 -1.547010e-04 -1.592861e-04 ......
## ASV0265      8.802285e-04  9.241314e-04  9.702291e-04  1.018627e-03 ......
## ASV3741      2.933685e-04  3.049858e-04  3.169649e-04  3.293091e-04 ......
## ASV0847      1.108309e-03  1.156664e-03  1.206951e-03  1.259233e-03 ......
## ASV1026      1.175155e-03  1.225613e-03  1.278015e-03  1.332418e-03 ......
## ASV1222     -3.008383e-04 -3.102273e-04 -3.197522e-04 -3.294050e-04 ......
## ASV0729      1.707839e-04  1.784908e-04  1.865259e-04  1.949017e-04 ......
## ASV0143     -8.557336e-04 -8.899428e-04 -9.252899e-04 -9.617974e-04 ......
## ASV1328      2.973059e-04  3.123812e-04  3.282261e-04  3.448779e-04 ......
## ASV9078     -3.112359e-04 -3.296327e-04 -3.491004e-04 -3.696939e-04 ......
## ASV0027     -1.352576e-03 -1.415007e-03 -1.480180e-03 -1.548202e-03 ......
## ASV0546     -5.204140e-04 -5.404942e-04 -5.611859e-04 -5.824968e-04 ......
## ASV1136      1.435644e-03  1.498178e-03  1.563248e-03  1.630948e-03 ......
## ASV3081      6.887062e-04  7.195963e-04  7.518400e-04  7.854968e-04 ......
## ASV0531      3.350613e-04  3.514284e-04  3.685738e-04  3.865309e-04 ......
## ASV2525      3.830768e-04  3.989537e-04  4.154172e-04  4.324848e-04 ......
## ASV1083     -1.000860e-04 -1.018729e-04 -1.035634e-04 -1.051458e-04 ......
## ASV0424      2.436775e-04  2.539724e-04  2.646565e-04  2.757419e-04 ......
## ASV0644      9.943590e-05  1.072480e-04  1.156035e-04  1.245323e-04 ......
## ASV6007     -1.183691e-04 -1.276906e-04 -1.376636e-04 -1.483248e-04 ......
## ASV0564      3.979913e-04  4.179260e-04  4.388336e-04  4.607561e-04 ......
## ASV1938      3.258671e-04  3.370152e-04  3.484049e-04  3.600336e-04 ......
## ASV6516     -8.802275e-04 -9.187847e-04 -9.589138e-04 -1.000671e-03 ......
## ASV0503     -9.471910e-04 -9.833253e-04 -1.020506e-03 -1.058739e-03 ......
## ASV6913     -1.006750e-03 -1.048971e-03 -1.092820e-03 -1.138354e-03 ......
## ASV0164     -8.457025e-04 -8.853553e-04 -9.268321e-04 -9.702130e-04 ......
## ASV1576      9.775194e-04  1.020745e-03  1.065800e-03  1.112758e-03 ......
## ASV1725      5.421531e-04  5.694255e-04  5.980304e-04  6.280253e-04 ......
## ASV4501      3.495781e-04  3.610430e-04  3.726872e-04  3.844981e-04 ......
## ASV10678    -8.594962e-04 -8.967582e-04 -9.355005e-04 -9.757724e-04 ......
## ASV0944      7.439781e-04  7.790316e-04  8.157119e-04  8.540921e-04 ......
## ASV2292      1.083022e-03  1.128546e-03  1.175759e-03  1.224708e-03 ......
## ASV1090      7.260939e-04  7.580771e-04  7.913813e-04  8.260552e-04 ......
## ASV9117     -2.865881e-04 -2.956322e-04 -3.048159e-04 -3.141320e-04 ......
## ASV0285     -5.199491e-04 -5.477447e-04 -5.770403e-04 -6.079136e-04 ......
## ASV0463     -6.552842e-04 -6.806673e-04 -7.068084e-04 -7.337126e-04 ......
## ASV3199      5.571652e-04  5.782682e-04  5.999893e-04  6.223351e-04 ......
## ASV0150     -2.850572e-04 -2.996348e-04 -3.149506e-04 -3.310394e-04 ......
## ASV6583     -3.005503e-04 -3.109715e-04 -3.216628e-04 -3.326288e-04 ......
## ASV0392      5.714369e-04  5.962670e-04  6.220873e-04  6.489310e-04 ......
## ASV14007    -6.741356e-04 -7.019244e-04 -7.306912e-04 -7.604579e-04 ......
## ASV0177     -3.462085e-04 -3.587363e-04 -3.715561e-04 -3.846610e-04 ......
## ASV6448     -3.839382e-04 -4.055267e-04 -4.283148e-04 -4.523617e-04 ......
## ASV5399     -1.940849e-04 -2.067408e-04 -2.201847e-04 -2.344581e-04 ......
## ASV0277     -1.486820e-04 -1.553603e-04 -1.623046e-04 -1.695212e-04 ......
## ASV2599      2.088390e-04  2.149161e-04  2.210493e-04  2.272324e-04 ......
## ASV13465    -1.488362e-04 -1.518763e-04 -1.548103e-04 -1.576219e-04 ......
## ASV2412      3.704287e-04  3.871217e-04  4.045353e-04  4.226984e-04 ......
## ASV0423      7.692823e-04  8.069661e-04  8.465098e-04  8.880043e-04 ......
## ASV5187      3.661942e-04  3.781837e-04  3.904041e-04  4.028506e-04 ......
## ASV0701     -1.751729e-03 -1.831766e-03 -1.915305e-03 -2.002484e-03 ......
## ASV4248      4.731312e-04  4.974034e-04  5.229013e-04  5.496813e-04 ......
## ASV0519      7.522629e-04  7.877738e-04  8.248985e-04  8.637023e-04 ......
## ASV0764      1.492817e-04  1.577715e-04  1.667523e-04  1.762506e-04 ......
## ASV5385     -9.124618e-04 -9.542871e-04 -9.979758e-04 -1.043608e-03 ......
## ASV3021     -4.525471e-04 -4.689855e-04 -4.858760e-04 -5.032233e-04 ......
## ASV4119     -2.339155e-04 -2.415122e-04 -2.492623e-04 -2.571660e-04 ......
## ASV2534      1.179875e-04  1.221221e-04  1.263603e-04  1.307023e-04 ......
## ASV1061      7.627097e-04  8.022197e-04  8.438273e-04  8.876434e-04 ......
## ASV0670      9.780278e-04  1.023014e-03  1.070010e-03  1.119100e-03 ......
## ASV1384      4.615751e-04  4.848881e-04  5.093451e-04  5.349954e-04 ......
## ASV1981      9.279311e-04  9.712946e-04  1.016611e-03  1.063961e-03 ......
## ASV9632     -1.960414e-04 -1.998342e-04 -2.034723e-04 -2.069348e-04 ......
## ASV4564      2.301531e-04  2.410026e-04  2.523408e-04  2.641865e-04 ......
## ASV5289     -2.197705e-04 -2.306185e-04 -2.420213e-04 -2.540090e-04 ......
## ASV0516      1.824688e-03  1.906581e-03  1.991916e-03  2.080820e-03 ......
## ASV1463     -6.309753e-04 -6.573111e-04 -6.846011e-04 -7.128689e-04 ......
## ASV0969      2.833707e-04  2.944714e-04  3.059039e-04  3.176689e-04 ......
## ASV1113     -8.475463e-04 -8.855736e-04 -9.252100e-04 -9.665159e-04 ......
## ASV1234     -1.137727e-04 -1.242280e-04 -1.355746e-04 -1.478811e-04 ......
## ASV3814      2.638864e-05  2.242628e-05  1.796750e-05  1.297683e-05 ......
## ASV1000      8.376154e-04  8.730408e-04  9.097835e-04  9.478785e-04 ......
## ASV0079     -1.061899e-04 -1.131881e-04 -1.206619e-04 -1.286423e-04 ......
## ASV0145      2.492143e-04  2.580312e-04  2.670657e-04  2.763175e-04 ......
## ASV0457     -1.058513e-03 -1.103107e-03 -1.149352e-03 -1.197292e-03 ......
## ASV1485      3.734116e-04  3.914673e-04  4.104034e-04  4.302629e-04 ......
## ASV0535     -2.013647e-04 -2.087242e-04 -2.162917e-04 -2.240709e-04 ......
## ASV0259     -7.132308e-04 -7.445044e-04 -7.770164e-04 -8.108034e-04 ......
## ASV0570      8.199425e-05  8.774655e-05  9.390073e-05  1.004829e-04 ......
## ASV0906      8.907817e-04  9.283509e-04  9.673258e-04  1.007746e-03 ......
## ASV1748     -6.102722e-04 -6.414560e-04 -6.742155e-04 -7.086234e-04 ......
## ASV5520     -3.896760e-04 -4.111287e-04 -4.337455e-04 -4.575823e-04 ......
## ASV2288     -1.062434e-03 -1.107974e-03 -1.155269e-03 -1.204371e-03 ......
## ASV1887     -2.666135e-04 -2.817159e-04 -2.976245e-04 -3.143738e-04 ......
## ASV0374     -2.983035e-04 -3.093594e-04 -3.207062e-04 -3.323425e-04 ......
## ASV0823      9.820193e-04  1.022329e-03  1.064087e-03  1.107336e-03 ......
## ASV0717      5.245240e-04  5.480995e-04  5.726707e-04  5.982741e-04 ......
## ASV0431      3.639789e-04  3.797728e-04  3.961995e-04  4.132812e-04 ......
## ASV1030      1.589068e-03  1.664461e-03  1.743356e-03  1.825906e-03 ......
## ASV1082     -2.263460e-04 -2.365597e-04 -2.472004e-04 -2.582826e-04 ......
## ASV2684      1.963216e-04  2.079784e-04  2.202876e-04  2.332788e-04 ......
## ASV0051      1.348559e-03  1.409792e-03  1.473688e-03  1.540356e-03 ......
## ASV0513      8.589209e-05  9.130638e-05  9.708466e-05  1.032517e-04 ......
## ASV0581      1.746845e-03  1.826561e-03  1.909751e-03  1.996552e-03 ......
## ASV7282      3.371929e-04  3.552521e-04  3.743147e-04  3.944370e-04 ......
## ASV3009     -9.459336e-04 -9.883913e-04 -1.032640e-03 -1.078744e-03 ......
## ASV2106     -4.377174e-04 -4.551073e-04 -4.731015e-04 -4.917173e-04 ......
## ASV1012      3.340170e-04  3.507098e-04  3.682088e-04  3.865484e-04 ......
## ASV0921     -5.319106e-06 -4.431801e-06 -3.399524e-06 -2.206605e-06 ......
## ASV0010     -1.375661e-03 -1.439284e-03 -1.505717e-03 -1.575072e-03 ......
## ASV1178      5.224833e-05  5.577600e-05  5.952258e-05  6.349841e-05 ......
## ASV2848     -6.846243e-04 -7.135824e-04 -7.436782e-04 -7.749529e-04 ......
## ASV0586      1.986800e-03  2.078029e-03  2.173287e-03  2.272738e-03 ......
## ASV4225      1.837935e-04  1.970129e-04  2.111052e-04  2.261182e-04 ......
## ASV2156     -8.314454e-04 -8.696465e-04 -9.095349e-04 -9.511789e-04 ......
## ASV9778     -5.062490e-04 -5.284462e-04 -5.515482e-04 -5.755874e-04 ......
## ASV0493     -1.079144e-03 -1.124422e-03 -1.171384e-03 -1.220078e-03 ......
## ASV3770      1.335052e-04  1.364380e-04  1.393065e-04  1.420996e-04 ......
## ASV0470      1.375922e-03  1.437293e-03  1.501243e-03  1.567869e-03 ......
## ASV0262     -6.504061e-04 -6.839026e-04 -7.191269e-04 -7.561640e-04 ......
## ASV0998      8.634046e-04  9.031536e-04  9.446745e-04  9.880415e-04 ......
## ASV7708     -1.989602e-04 -2.061566e-04 -2.135167e-04 -2.210357e-04 ......
## ASV0453     -1.944081e-05 -2.019980e-05 -2.101390e-05 -2.189033e-05 ......
## ASV0044      1.722900e-03  1.799446e-03  1.879170e-03  1.962187e-03 ......
## ASV5490      2.576492e-04  2.678995e-04  2.784606e-04  2.893326e-04 ......
## ASV2638      1.202222e-04  1.274580e-04  1.351099e-04  1.431976e-04 ......
## ASV0829     -1.157590e-04 -1.187961e-04 -1.218320e-04 -1.248614e-04 ......
## ASV0601      3.346558e-04  3.509339e-04  3.680047e-04  3.859061e-04 ......
## ASV0234      7.722615e-04  8.073636e-04  8.439938e-04  8.822136e-04 ......
## ASV0133      9.895206e-04  1.033572e-03  1.079450e-03  1.127219e-03 ......
## ASV0323      1.093901e-03  1.145734e-03  1.200008e-03  1.256835e-03 ......
## ASV0854     -7.496168e-05 -7.758614e-05 -8.026254e-05 -8.298851e-05 ......
## ASV0110      1.343152e-03  1.404339e-03  1.468193e-03  1.534820e-03 ......
## ASV0816      6.689147e-05  6.952764e-05  7.225262e-05  7.506897e-05 ......
## ASV1031     -1.747170e-04 -1.809865e-04 -1.874251e-04 -1.940353e-04 ......
## ASV0144     -5.465165e-04 -5.708655e-04 -5.962335e-04 -6.226575e-04 ......
## ASV0020     -2.891256e-04 -3.054678e-04 -3.228083e-04 -3.412117e-04 ......
## ASV0962     -4.430678e-04 -4.625033e-04 -4.827096e-04 -5.037096e-04 ......
## ASV0794      9.446205e-04  9.907544e-04  1.039099e-03  1.089753e-03 ......
## ASV7117     -4.281878e-04 -4.464281e-04 -4.653724e-04 -4.850435e-04 ......
## ASV1008     -3.474506e-04 -3.645699e-04 -3.825410e-04 -4.014060e-04 ......
## ASV0096      1.444347e-03  1.510055e-03  1.578617e-03  1.650147e-03 ......
## ASV0128     -9.181320e-04 -9.635195e-04 -1.011198e-03 -1.061283e-03 ......
## ASV5232      7.104683e-04  7.449223e-04  7.810238e-04  8.188473e-04 ......
## ASV0031      3.849970e-05  3.944277e-05  4.036800e-05  4.127128e-05 ......
## ASV1744     -8.596618e-05 -9.002915e-05 -9.432586e-05 -9.887460e-05 ......
## ASV0289      8.075755e-04  8.445176e-04  8.831061e-04  9.234116e-04 ......
## ASV7413     -2.621027e-04 -2.783907e-04 -2.956795e-04 -3.140243e-04 ......
## ASV0822     -9.158662e-04 -9.534686e-04 -9.923838e-04 -1.032641e-03 ......
## ASV8111     -8.069121e-04 -8.408279e-04 -8.760542e-04 -9.126362e-04 ......
## ASV0687      6.472133e-04  6.784427e-04  7.111426e-04  7.453765e-04 ......
## ASV0112      1.930308e-04  1.998278e-04  2.067601e-04  2.138211e-04 ......
## ASV0987      5.283705e-04  5.546594e-04  5.822890e-04  6.113294e-04 ......
## ASV5332     -1.933440e-04 -1.990458e-04 -2.048447e-04 -2.107425e-04 ......
## ASV1129     -6.369466e-04 -6.661085e-04 -6.965750e-04 -7.284029e-04 ......
## ASV1274     -2.032416e-04 -2.122652e-04 -2.216652e-04 -2.314557e-04 ......
## ASV0119      1.175047e-03  1.228371e-03  1.284001e-03  1.342027e-03 ......
## ASV0890      2.942240e-04  3.076704e-04  3.216928e-04  3.363119e-04 ......
## ASV0848      1.718198e-03  1.796837e-03  1.878924e-03  1.964598e-03 ......
## ASV5944     -9.074956e-04 -9.474570e-04 -9.890569e-04 -1.032354e-03 ......
## ASV19741    -8.616430e-04 -8.994113e-04 -9.387190e-04 -9.796211e-04 ......
## ASV0504     -9.621135e-04 -1.002264e-03 -1.043888e-03 -1.087025e-03 ......
## ASV2146     -6.102672e-04 -6.356769e-04 -6.620671e-04 -6.894738e-04 ......
## ASV0089     -5.471627e-04 -5.721889e-04 -5.983032e-04 -6.255472e-04 ......
## ASV2301     -6.038306e-04 -6.319963e-04 -6.614421e-04 -6.922226e-04 ......
## ASV2982      2.990984e-04  3.171922e-04  3.363491e-04  3.566237e-04 ......
## ASV0891     -7.293166e-04 -7.614434e-04 -7.948764e-04 -8.296596e-04 ......
## ASV0093      1.202042e-03  1.255886e-03  1.312006e-03  1.370485e-03 ......
## ASV0042      5.829015e-04  6.090352e-04  6.362760e-04  6.646659e-04 ......
## ASV0980      7.673063e-04  7.994821e-04  8.328233e-04  8.673573e-04 ......
## ASV0069     -2.037099e-04 -2.135139e-04 -2.237811e-04 -2.345319e-04 ......
## ASV1364     -1.196894e-04 -1.241449e-04 -1.287105e-04 -1.333837e-04 ......
## ASV0524     -2.477279e-04 -2.601502e-04 -2.732084e-04 -2.869349e-04 ......
## ASV0435      1.630494e-03  1.705701e-03  1.784265e-03  1.866325e-03 ......
## ASV0517     -6.692513e-04 -7.002463e-04 -7.326380e-04 -7.664863e-04 ......
## ASV3167     -3.154800e-04 -3.313987e-04 -3.481237e-04 -3.656945e-04 ......
## ASV4280     -8.687610e-05 -9.013929e-05 -9.350465e-05 -9.697549e-05 ......
## ASV1158      4.391102e-04  4.609823e-04  4.838858e-04  5.078608e-04 ......
## ASV2214      2.774550e-04  2.894159e-04  3.018856e-04  3.148881e-04 ......
## ASV0544     -3.875867e-04 -4.064180e-04 -4.261645e-04 -4.468695e-04 ......
## ASV5326     -6.603734e-05 -6.906385e-05 -7.223610e-05 -7.556264e-05 ......
## ASV3765     -9.552619e-04 -9.981198e-04 -1.042779e-03 -1.089306e-03 ......
## ASV4646     -6.962129e-05 -7.551966e-05 -8.184396e-05 -8.861840e-05 ......
## ASV0090      8.297358e-05  8.548835e-05  8.800421e-05  9.051237e-05 ......
## ASV3680      8.083221e-04  8.400593e-04  8.727790e-04  9.064911e-04 ......
## ASV0111      1.361749e-04  1.412054e-04  1.463551e-04  1.516208e-04 ......
## ASV0768      5.777166e-04  6.053906e-04  6.343948e-04  6.647934e-04 ......
## ASV4862     -1.117662e-05 -1.045610e-05 -9.591824e-06 -8.567920e-06 ......
## ASV1742     -6.625323e-04 -6.891810e-04 -7.167520e-04 -7.452683e-04 ......
## ASV3701     -7.118539e-05 -7.268010e-05 -7.412942e-05 -7.552582e-05 ......
## ASV2386     -4.372075e-04 -4.567024e-04 -4.770038e-04 -4.981393e-04 ......
## ASV0375     -9.788597e-04 -1.020444e-03 -1.063629e-03 -1.108463e-03 ......
## ASV2796      2.353365e-04  2.444485e-04  2.538695e-04  2.636100e-04 ......
## ASV1369      6.745048e-04  7.035765e-04  7.338376e-04  7.653351e-04 ......
## ASV10272    -6.239784e-04 -6.510199e-04 -6.791192e-04 -7.083084e-04 ......
## ASV10354    -6.238317e-04 -6.508603e-04 -6.789456e-04 -7.081195e-04 ......
## ASV1067     -4.627590e-05 -4.820205e-05 -5.019581e-05 -5.225854e-05 ......
## ASV1900      1.355103e-03  1.417483e-03  1.482635e-03  1.550672e-03 ......
## ASV4079     -2.395099e-04 -2.509863e-04 -2.629977e-04 -2.755665e-04 ......
## ASV4149      8.351149e-04  8.684667e-04  9.029023e-04  9.384387e-04 ......
## ASV5140     -6.236814e-04 -6.506964e-04 -6.787670e-04 -7.079249e-04 ......
## ASV10782    -8.920805e-07  7.902839e-07  2.697814e-06  4.852349e-06 ......
## ASV4273     -1.266122e-04 -1.308323e-04 -1.351019e-04 -1.394117e-04 ......
## ASV8121      6.183218e-04  6.466428e-04  6.762226e-04  7.071149e-04 ......
## ASV8438     -6.235705e-04 -6.505771e-04 -6.786388e-04 -7.077873e-04 ......
## ASV9390     -6.234239e-04 -6.504176e-04 -6.784653e-04 -7.075987e-04 ......
## ASV1340      9.046830e-04  9.468109e-04  9.908438e-04  1.036861e-03 ......
## ASV2650     -9.109878e-04 -9.493394e-04 -9.890999e-04 -1.030305e-03 ......
## ASV4674      4.811870e-04  5.026211e-04  5.249404e-04  5.481750e-04 ......
## ASV10492    -2.987455e-05 -3.090444e-05 -3.195712e-05 -3.303254e-05 ......
## ASV11430    -6.232209e-04 -6.501977e-04 -6.782271e-04 -7.073409e-04 ......
## ASV12135    -6.230746e-04 -6.500384e-04 -6.780539e-04 -7.071526e-04 ......
## ASV14970    -6.229283e-04 -6.498792e-04 -6.778808e-04 -7.069643e-04 ......
## ASV1954      7.313044e-04  7.642925e-04  7.986774e-04  8.345096e-04 ......
## ASV2613      1.126969e-03  1.176992e-03  1.229080e-03  1.283308e-03 ......
## ASV2757      4.217798e-04  4.388024e-04  4.563956e-04  4.745704e-04 ......
## ASV2909     -6.918431e-04 -7.243389e-04 -7.583385e-04 -7.939096e-04 ......
## ASV2954     -1.224195e-04 -1.272534e-04 -1.322352e-04 -1.373660e-04 ......
## ASV2969      6.563731e-04  6.877860e-04  7.206956e-04  7.551718e-04 ......
## ASV3410      1.454874e-04  1.531441e-04  1.612222e-04  1.697452e-04 ......
## ASV3575      3.285475e-04  3.432583e-04  3.585984e-04  3.745930e-04 ......
## ASV4275      6.945437e-04  7.233292e-04  7.531339e-04  7.839803e-04 ......
## ASV4652      1.418083e-04  1.494236e-04  1.574645e-04  1.659549e-04 ......
## ASV4761      6.943625e-04  7.230846e-04  7.528067e-04  7.835480e-04 ......
## ASV6003      5.892172e-04  6.181237e-04  6.484703e-04  6.803293e-04 ......
## ASV6110     -6.232673e-04 -6.502502e-04 -6.782866e-04 -7.074083e-04 ......
## ASV7427      4.062653e-04  4.240636e-04  4.425752e-04  4.618234e-04 ......
## ASV8092     -6.231730e-04 -6.501477e-04 -6.781751e-04 -7.072871e-04 ......
## ASV8169     -6.230267e-04 -6.499884e-04 -6.780019e-04 -7.070987e-04 ......
## ASV9693      2.794588e-04  2.920906e-04  3.052576e-04  3.189787e-04 ......
## ASV10913     3.162312e-04  3.313942e-04  3.472789e-04  3.639183e-04 ......
## ASV1979     -9.264260e-05 -9.618020e-05 -9.982249e-05 -1.035708e-04 ......
## ASV3772      7.657946e-04  7.987220e-04  8.329323e-04  8.684662e-04 ......
## ASV0113      1.513559e-04  1.577494e-04  1.643868e-04  1.712763e-04 ......
## ASV1800     -5.747438e-05 -5.951250e-05 -6.156906e-05 -6.363695e-05 ......
## ASV2335     -7.976155e-04 -8.315032e-04 -8.667236e-04 -9.033239e-04 ......
## ASV0692      2.728448e-04  2.852139e-04  2.981063e-04  3.115401e-04 ......
## ASV1120      3.549469e-04  3.712901e-04  3.883631e-04  4.061966e-04 ......
## ASV1434     -1.866092e-03 -1.951230e-03 -2.040095e-03 -2.132837e-03 ......
## ASV0076     -2.130652e-04 -2.232397e-04 -2.338888e-04 -2.450329e-04 ......
## ASV0361      1.399658e-03  1.463776e-03  1.530718e-03  1.600601e-03 ......
## ASV2231     -5.080511e-04 -5.343227e-04 -5.619951e-04 -5.911429e-04 ......
## ASV2018     -2.333869e-05 -2.469640e-05 -2.614572e-05 -2.769392e-05 ......
## ASV1529      1.195758e-03  1.252397e-03  1.311694e-03  1.373771e-03 ......
## ASV0841     -4.300795e-05 -4.392379e-05 -4.479268e-05 -4.560606e-05 ......
## ASV2556     -6.815424e-04 -7.113021e-04 -7.422479e-04 -7.744179e-04 ......
## ASV2777      8.097530e-04  8.416620e-04  8.745691e-04  9.084862e-04 ......
## ASV0355      7.186264e-04  7.514347e-04  7.856864e-04  8.214409e-04 ......
## ASV5169     -9.925040e-04 -1.036932e-03 -1.083214e-03 -1.131416e-03 ......
## ASV3091      4.974929e-04  5.213105e-04  5.462675e-04  5.724178e-04 ......
## ASV2435      7.013306e-04  7.325856e-04  7.651374e-04  7.990316e-04 ......
## ASV6822     -4.303310e-04 -4.485221e-04 -4.673830e-04 -4.869303e-04 ......
## ASV12605    -1.078823e-03 -1.127115e-03 -1.177435e-03 -1.229859e-03 ......
## ASV0286     -7.091248e-04 -7.408489e-04 -7.739444e-04 -8.084689e-04 ......
## ASV0074     -5.677768e-05 -6.120994e-05 -6.597841e-05 -7.110655e-05 ......
## ASV2485     -7.440336e-05 -7.946361e-05 -8.490947e-05 -9.077154e-05 ......
## ASV1233     -1.385943e-03 -1.449225e-03 -1.515296e-03 -1.584273e-03 ......
## ASV0356     -6.342891e-04 -6.616685e-04 -6.901418e-04 -7.197476e-04 ......
## ASV2918     -8.191814e-04 -8.551197e-04 -8.925196e-04 -9.314321e-04 ......
## ASV1427     -5.191260e-06 -6.032622e-06 -6.967672e-06 -8.005544e-06 ......
## ASV1409      8.242558e-04  8.632475e-04  9.040641e-04  9.467886e-04 ......
## ASV0770      2.410797e-04  2.504999e-04  2.601919e-04  2.701543e-04 ......
## ASV1403     -9.578793e-04 -1.000378e-03 -1.044633e-03 -1.090706e-03 ......
## ASV0314     -5.231198e-04 -5.465097e-04 -5.708670e-04 -5.962239e-04 ......
## ASV0187     -1.258212e-05 -1.469726e-05 -1.701343e-05 -1.954507e-05 ......
## ASV0313     -7.026839e-04 -7.335729e-04 -7.657097e-04 -7.991356e-04 ......
## ASV1087      1.222878e-03  1.278293e-03  1.336102e-03  1.396399e-03 ......
## ASV1970      7.020404e-05  7.330957e-05  7.655133e-05  7.993603e-05 ......
## ASV0754      9.885108e-04  1.033495e-03  1.080439e-03  1.129421e-03 ......
## ASV3775     -6.882720e-04 -7.205923e-04 -7.544053e-04 -7.897776e-04 ......
## ASV0132      2.821832e-04  2.947747e-04  3.078912e-04  3.215516e-04 ......
## ASV2329     -2.268361e-04 -2.394199e-04 -2.526833e-04 -2.666577e-04 ......
## ASV0561      8.407801e-04  8.777238e-04  9.161558e-04  9.561244e-04 ......
## ASV0130     -1.049501e-03 -1.097632e-03 -1.147874e-03 -1.200311e-03 ......
## ASV0226      1.169370e-03  1.222045e-03  1.276960e-03  1.334198e-03 ......
## ASV12648    -7.963899e-04 -8.310666e-04 -8.671746e-04 -9.047694e-04 ......
## ASV0204      1.165506e-03  1.217980e-03  1.272681e-03  1.329693e-03 ......
## ASV0767      1.895764e-04  1.967436e-04  2.040937e-04  2.116228e-04 ......
## ASV0335     -6.386141e-04 -6.675149e-04 -6.976469e-04 -7.290551e-04 ......
## ASV5901     -1.730653e-04 -1.797663e-04 -1.866908e-04 -1.938451e-04 ......
## ASV0596     -2.355586e-04 -2.446126e-04 -2.539195e-04 -2.634781e-04 ......
## ASV9271      2.976080e-04  3.142750e-04  3.318761e-04  3.504592e-04 ......
## ASV0904      1.057631e-03  1.106993e-03  1.158606e-03  1.212565e-03 ......
## ASV15270    -3.274321e-04 -3.446698e-04 -3.627770e-04 -3.817894e-04 ......
## ASV0990     -2.976061e-04 -3.115925e-04 -3.262252e-04 -3.415326e-04 ......
## ASV0155     -6.252927e-04 -6.535714e-04 -6.830664e-04 -7.138246e-04 ......
## ASV0086     -9.702634e-06 -1.018994e-05 -1.070147e-05 -1.123835e-05 ......
## ASV2581     -4.541706e-05 -4.692387e-05 -4.843443e-05 -4.994201e-05 ......
## ASV1579     -7.494787e-04 -7.850682e-04 -8.223243e-04 -8.613217e-04 ......
## ASV7730     -5.965531e-05 -6.399562e-05 -6.859126e-05 -7.345013e-05 ......
## ASV0897      3.185871e-04  3.339227e-04  3.499946e-04  3.668372e-04 ......
## ASV1975      1.418190e-03  1.482797e-03  1.550244e-03  1.620647e-03 ......
## 
##  .....suppressing 68 columns in show(); maybe adjust 'options(max.print= *, width = *)'
##  ..............................

stats:glm

1000

library(stats)

logreg_1000 <- stats::glm(as.factor(Clade) ~ . ,
                          data = lr_clr_df_1000[,-1],
                          family = "binomial")
summary(logreg_1000)
## 
## Call:
## stats::glm(formula = as.factor(Clade) ~ ., family = "binomial", 
##     data = lr_clr_df_1000[, -1])
## 
## Coefficients: (756 not defined because of singularities)
##               Estimate Std. Error    z value Pr(>|z|)    
## (Intercept)  2.181e+20  7.431e+06  2.935e+13   <2e-16 ***
## ASV1236      6.843e+28  6.565e+21  1.042e+07   <2e-16 ***
## ASV0421     -2.125e+29  8.469e+21 -2.509e+07   <2e-16 ***
## ASV0691     -1.791e+30  3.961e+22 -4.522e+07   <2e-16 ***
## ASV0899      2.828e+29  6.932e+21  4.079e+07   <2e-16 ***
## ASV1004     -5.579e+28  6.422e+21 -8.686e+06   <2e-16 ***
## ASV1041      3.267e+29  9.988e+21  3.271e+07   <2e-16 ***
## ASV1058     -1.516e+29  8.598e+21 -1.763e+07   <2e-16 ***
## ASV12542    -2.601e+29  1.479e+22 -1.758e+07   <2e-16 ***
## ASV1294      3.981e+29  1.038e+22  3.837e+07   <2e-16 ***
## ASV13113     1.128e+28  2.153e+20  5.239e+07   <2e-16 ***
## ASV1318     -4.843e+28  3.619e+21 -1.338e+07   <2e-16 ***
## ASV2269     -1.889e+29  5.505e+22 -3.431e+06   <2e-16 ***
## ASV2542      2.144e+28  1.016e+21  2.110e+07   <2e-16 ***
## ASV2660     -8.576e+29  1.978e+22 -4.336e+07   <2e-16 ***
## ASV2737     -1.390e+30  2.788e+22 -4.987e+07   <2e-16 ***
## ASV2840      9.305e+28  1.891e+21  4.922e+07   <2e-16 ***
## ASV3053      1.577e+30  2.347e+22  6.718e+07   <2e-16 ***
## ASV3077     -1.226e+30  2.775e+22 -4.418e+07   <2e-16 ***
## ASV3134      2.682e+27  3.011e+20  8.908e+06   <2e-16 ***
## ASV3140     -3.274e+28  8.068e+21 -4.057e+06   <2e-16 ***
## ASV3579      1.942e+27  1.009e+21  1.925e+06   <2e-16 ***
## ASV6119             NA         NA         NA       NA    
## ASV7557             NA         NA         NA       NA    
## ASV8422             NA         NA         NA       NA    
## ASV1086             NA         NA         NA       NA    
## ASV1310     -3.378e+29  5.810e+21 -5.813e+07   <2e-16 ***
## ASV15750     6.602e+29  1.968e+22  3.355e+07   <2e-16 ***
## ASV16905            NA         NA         NA       NA    
## ASV2033     -3.837e+28  4.522e+21 -8.484e+06   <2e-16 ***
## ASV2089             NA         NA         NA       NA    
## ASV2127      9.866e+28  3.808e+21  2.591e+07   <2e-16 ***
## ASV2725      6.243e+29  1.186e+22  5.266e+07   <2e-16 ***
## ASV2804             NA         NA         NA       NA    
## ASV3075     -1.559e+29  3.291e+21 -4.737e+07   <2e-16 ***
## ASV3327     -7.253e+28  4.365e+21 -1.662e+07   <2e-16 ***
## ASV3342      3.521e+28  1.341e+21  2.625e+07   <2e-16 ***
## ASV3532     -9.250e+28  4.111e+21 -2.250e+07   <2e-16 ***
## ASV3600     -1.661e+29  2.759e+21 -6.020e+07   <2e-16 ***
## ASV4013     -5.397e+28  1.033e+22 -5.224e+06   <2e-16 ***
## ASV4136     -3.600e+29  6.267e+21 -5.744e+07   <2e-16 ***
## ASV4195             NA         NA         NA       NA    
## ASV4407             NA         NA         NA       NA    
## ASV4717             NA         NA         NA       NA    
## ASV6794             NA         NA         NA       NA    
## ASV8324             NA         NA         NA       NA    
## ASV8981     -3.369e+28  2.812e+21 -1.198e+07   <2e-16 ***
## ASV9859      2.474e+29  5.038e+21  4.910e+07   <2e-16 ***
## ASV0936      1.058e+29  9.123e+21  1.160e+07   <2e-16 ***
## ASV12683            NA         NA         NA       NA    
## ASV1293      3.356e+29  4.996e+21  6.717e+07   <2e-16 ***
## ASV13055            NA         NA         NA       NA    
## ASV17063            NA         NA         NA       NA    
## ASV2228             NA         NA         NA       NA    
## ASV2769      7.803e+29  2.103e+22  3.710e+07   <2e-16 ***
## ASV2803     -8.397e+29  1.148e+22 -7.316e+07   <2e-16 ***
## ASV2896     -2.995e+28  9.858e+20 -3.039e+07   <2e-16 ***
## ASV3062             NA         NA         NA       NA    
## ASV3107      1.849e+28  4.648e+20  3.979e+07   <2e-16 ***
## ASV3265      3.898e+29  7.889e+21  4.941e+07   <2e-16 ***
## ASV3666             NA         NA         NA       NA    
## ASV4497      1.272e+30  2.641e+22  4.816e+07   <2e-16 ***
## ASV6914             NA         NA         NA       NA    
## ASV0576      9.576e+29  2.825e+22  3.390e+07   <2e-16 ***
## ASV0673     -2.808e+29  1.104e+22 -2.542e+07   <2e-16 ***
## ASV0772      5.216e+29  1.668e+22  3.128e+07   <2e-16 ***
## ASV0862             NA         NA         NA       NA    
## ASV0898             NA         NA         NA       NA    
## ASV0910      6.409e+28  1.250e+21  5.126e+07   <2e-16 ***
## ASV0964             NA         NA         NA       NA    
## ASV10059     4.840e+28  7.875e+20  6.146e+07   <2e-16 ***
## ASV10263            NA         NA         NA       NA    
## ASV1088      2.491e+28  4.342e+21  5.736e+06   <2e-16 ***
## ASV1101             NA         NA         NA       NA    
## ASV1183     -7.674e+28  1.386e+21 -5.538e+07   <2e-16 ***
## ASV11956            NA         NA         NA       NA    
## ASV12774            NA         NA         NA       NA    
## ASV1321             NA         NA         NA       NA    
## ASV13793            NA         NA         NA       NA    
## ASV14482            NA         NA         NA       NA    
## ASV15483            NA         NA         NA       NA    
## ASV2062             NA         NA         NA       NA    
## ASV2132      4.743e+28  2.465e+21  1.924e+07   <2e-16 ***
## ASV2413             NA         NA         NA       NA    
## ASV2490             NA         NA         NA       NA    
## ASV2594      8.244e+28  2.002e+21  4.117e+07   <2e-16 ***
## ASV2822             NA         NA         NA       NA    
## ASV2863             NA         NA         NA       NA    
## ASV2910             NA         NA         NA       NA    
## ASV2980      2.402e+29  1.044e+22  2.301e+07   <2e-16 ***
## ASV3307             NA         NA         NA       NA    
## ASV3474             NA         NA         NA       NA    
## ASV3502     -3.889e+29  7.890e+21 -4.929e+07   <2e-16 ***
## ASV4236             NA         NA         NA       NA    
## ASV4842             NA         NA         NA       NA    
## ASV4894             NA         NA         NA       NA    
## ASV5290             NA         NA         NA       NA    
## ASV5501     -5.250e+28  1.329e+22 -3.951e+06   <2e-16 ***
## ASV5795             NA         NA         NA       NA    
## ASV5987             NA         NA         NA       NA    
## ASV6267             NA         NA         NA       NA    
## ASV6862             NA         NA         NA       NA    
## ASV7145             NA         NA         NA       NA    
## ASV7673             NA         NA         NA       NA    
## ASV7789             NA         NA         NA       NA    
## ASV7809             NA         NA         NA       NA    
## ASV8002             NA         NA         NA       NA    
## ASV8205     -2.181e+28  6.973e+20 -3.128e+07   <2e-16 ***
## ASV9155             NA         NA         NA       NA    
## ASV9221     -6.642e+28  4.031e+21 -1.648e+07   <2e-16 ***
## ASV9311             NA         NA         NA       NA    
## ASV9557             NA         NA         NA       NA    
## ASV9936             NA         NA         NA       NA    
## ASV1445      9.816e+28  5.247e+21  1.871e+07   <2e-16 ***
## ASV4232     -1.318e+28  3.626e+20 -3.634e+07   <2e-16 ***
## ASV6479      1.619e+28  1.908e+21  8.487e+06   <2e-16 ***
## ASV0142      4.350e+29  2.213e+22  1.965e+07   <2e-16 ***
## ASV0378      1.908e+29  5.634e+21  3.386e+07   <2e-16 ***
## ASV1122      1.472e+28  3.307e+21  4.451e+06   <2e-16 ***
## ASV0123      2.039e+29  2.407e+22  8.468e+06   <2e-16 ***
## ASV2064     -1.651e+29  5.834e+21 -2.831e+07   <2e-16 ***
## ASV4459     -2.334e+29  4.085e+21 -5.712e+07   <2e-16 ***
## ASV0448     -5.357e+28  1.358e+21 -3.946e+07   <2e-16 ***
## ASV0397     -6.005e+28  2.968e+21 -2.023e+07   <2e-16 ***
## ASV0485      2.464e+28  2.217e+21  1.111e+07   <2e-16 ***
## ASV1566             NA         NA         NA       NA    
## ASV1365     -2.595e+29  6.024e+21 -4.307e+07   <2e-16 ***
## ASV1065     -3.016e+28  3.413e+21 -8.836e+06   <2e-16 ***
## ASV0722      2.000e+28  3.179e+21  6.290e+06   <2e-16 ***
## ASV12660            NA         NA         NA       NA    
## ASV0223     -1.950e+28  1.096e+21 -1.779e+07   <2e-16 ***
## ASV0229      5.491e+28  5.564e+21  9.870e+06   <2e-16 ***
## ASV0877      1.732e+29  5.588e+21  3.099e+07   <2e-16 ***
## ASV0983      4.495e+28  5.181e+21  8.676e+06   <2e-16 ***
## ASV0626             NA         NA         NA       NA    
## ASV4146      5.245e+29  9.837e+21  5.332e+07   <2e-16 ***
## ASV4175      1.852e+29  4.999e+21  3.704e+07   <2e-16 ***
## ASV2082      7.412e+28  1.056e+22  7.021e+06   <2e-16 ***
## ASV2272      2.267e+28  9.121e+20  2.485e+07   <2e-16 ***
## ASV2245      7.820e+28  3.787e+21  2.065e+07   <2e-16 ***
## ASV0590             NA         NA         NA       NA    
## ASV0217     -8.823e+28  1.654e+21 -5.334e+07   <2e-16 ***
## ASV0416     -4.486e+29  1.034e+22 -4.340e+07   <2e-16 ***
## ASV1056     -8.295e+28  1.750e+21 -4.739e+07   <2e-16 ***
## ASV7777      4.627e+27  1.558e+20  2.970e+07   <2e-16 ***
## ASV0455      3.573e+28  1.333e+21  2.680e+07   <2e-16 ***
## ASV0604             NA         NA         NA       NA    
## ASV6100      3.843e+27  1.225e+20  3.136e+07   <2e-16 ***
## ASV11359    -1.408e+29  4.272e+21 -3.296e+07   <2e-16 ***
## ASV6604      3.014e+28  1.678e+21  1.796e+07   <2e-16 ***
## ASV5004      1.131e+29  4.034e+21  2.804e+07   <2e-16 ***
## ASV1483      1.648e+29  3.333e+21  4.944e+07   <2e-16 ***
## ASV9773      8.011e+26  6.790e+19  1.180e+07   <2e-16 ***
## ASV4059     -7.565e+27  6.979e+20 -1.084e+07   <2e-16 ***
## ASV1193      3.081e+28  6.538e+20  4.712e+07   <2e-16 ***
## ASV4610             NA         NA         NA       NA    
## ASV0742             NA         NA         NA       NA    
## ASV1502     -1.969e+29  3.324e+21 -5.924e+07   <2e-16 ***
## ASV0195      5.334e+28  3.274e+21  1.629e+07   <2e-16 ***
## ASV1213     -1.224e+29  1.924e+21 -6.365e+07   <2e-16 ***
## ASV1648      1.432e+29  2.136e+21  6.707e+07   <2e-16 ***
## ASV6984      1.083e+28  7.837e+20  1.382e+07   <2e-16 ***
## ASV0396     -7.589e+27  1.410e+21 -5.382e+06   <2e-16 ***
## ASV4297             NA         NA         NA       NA    
## ASV2622     -1.238e+29  4.775e+21 -2.592e+07   <2e-16 ***
## ASV3512      1.911e+28  4.142e+20  4.614e+07   <2e-16 ***
## ASV2411             NA         NA         NA       NA    
## ASV2291             NA         NA         NA       NA    
## ASV0807      2.212e+28  1.682e+21  1.315e+07   <2e-16 ***
## ASV1292      7.530e+28  1.205e+21  6.247e+07   <2e-16 ***
## ASV1035             NA         NA         NA       NA    
## ASV0070      4.973e+27  4.139e+20  1.202e+07   <2e-16 ***
## ASV0255     -3.629e+28  1.193e+21 -3.041e+07   <2e-16 ***
## ASV0057      5.395e+26  1.025e+21  5.264e+05   <2e-16 ***
## ASV0077     -1.765e+28  6.104e+20 -2.892e+07   <2e-16 ***
## ASV0625      1.340e+29  4.545e+21  2.948e+07   <2e-16 ***
## ASV2464             NA         NA         NA       NA    
## ASV1315     -3.051e+28  1.180e+21 -2.585e+07   <2e-16 ***
## ASV2673      1.431e+27  3.871e+20  3.698e+06   <2e-16 ***
## ASV2161     -1.590e+27  8.061e+20 -1.973e+06   <2e-16 ***
## ASV0337      9.545e+27  1.443e+21  6.615e+06   <2e-16 ***
## ASV7680     -4.463e+28  1.901e+21 -2.348e+07   <2e-16 ***
## ASV0611      1.981e+27  7.246e+20  2.733e+06   <2e-16 ***
## ASV3118      5.867e+28  3.496e+21  1.678e+07   <2e-16 ***
## ASV1284     -9.127e+28  2.213e+21 -4.124e+07   <2e-16 ***
## ASV0889             NA         NA         NA       NA    
## ASV4649     -9.087e+28  3.138e+21 -2.896e+07   <2e-16 ***
## ASV1108     -1.176e+29  1.806e+21 -6.514e+07   <2e-16 ***
## ASV0738     -4.152e+27  5.188e+20 -8.003e+06   <2e-16 ***
## ASV0473      1.001e+28  3.810e+20  2.627e+07   <2e-16 ***
## ASV0598             NA         NA         NA       NA    
## ASV0429     -2.295e+29  3.948e+21 -5.813e+07   <2e-16 ***
## ASV1549      2.011e+28  4.986e+20  4.034e+07   <2e-16 ***
## ASV1203      5.484e+28  1.606e+21  3.415e+07   <2e-16 ***
## ASV4532     -1.270e+28  3.276e+20 -3.877e+07   <2e-16 ***
## ASV0274     -8.180e+28  1.360e+21 -6.013e+07   <2e-16 ***
## ASV0163     -7.621e+28  3.415e+21 -2.231e+07   <2e-16 ***
## ASV1298     -1.336e+28  6.106e+20 -2.188e+07   <2e-16 ***
## ASV9424      6.333e+28  2.559e+21  2.475e+07   <2e-16 ***
## ASV0412     -4.110e+28  2.051e+21 -2.003e+07   <2e-16 ***
## ASV0284      1.088e+29  1.478e+21  7.364e+07   <2e-16 ***
## ASV0620             NA         NA         NA       NA    
## ASV0153      7.133e+28  1.156e+21  6.172e+07   <2e-16 ***
## ASV0498     -2.297e+28  6.341e+20 -3.622e+07   <2e-16 ***
## ASV0097      2.563e+28  9.050e+20  2.832e+07   <2e-16 ***
## ASV0104      5.319e+28  1.265e+21  4.204e+07   <2e-16 ***
## ASV1282     -4.759e+28  2.912e+21 -1.634e+07   <2e-16 ***
## ASV3883     -2.912e+28  1.400e+21 -2.080e+07   <2e-16 ***
## ASV0801      9.603e+28  1.981e+21  4.847e+07   <2e-16 ***
## ASV1611     -1.216e+29  1.608e+21 -7.562e+07   <2e-16 ***
## ASV0227      1.810e+28  1.208e+21  1.499e+07   <2e-16 ***
## ASV0833             NA         NA         NA       NA    
## ASV0718      3.770e+28  8.795e+20  4.286e+07   <2e-16 ***
## ASV1139             NA         NA         NA       NA    
## ASV0766      1.079e+29  3.854e+21  2.801e+07   <2e-16 ***
## ASV2091      1.820e+28  1.696e+21  1.073e+07   <2e-16 ***
## ASV1238      1.525e+29  2.482e+21  6.145e+07   <2e-16 ***
## ASV9193             NA         NA         NA       NA    
## ASV0290     -5.185e+28  1.421e+21 -3.649e+07   <2e-16 ***
## ASV0231     -4.546e+27  1.749e+21 -2.600e+06   <2e-16 ***
## ASV0185     -1.370e+28  8.453e+20 -1.620e+07   <2e-16 ***
## ASV2330             NA         NA         NA       NA    
## ASV3119      1.212e+27  3.322e+20  3.649e+06   <2e-16 ***
## ASV2368     -1.917e+28  2.505e+20 -7.651e+07   <2e-16 ***
## ASV0122      2.972e+28  6.283e+20  4.730e+07   <2e-16 ***
## ASV1044     -5.002e+28  7.894e+20 -6.337e+07   <2e-16 ***
## ASV0160      4.804e+28  1.204e+21  3.989e+07   <2e-16 ***
## ASV0326     -2.974e+27  1.081e+20 -2.750e+07   <2e-16 ***
## ASV1388      2.563e+28  1.580e+21  1.622e+07   <2e-16 ***
## ASV0792             NA         NA         NA       NA    
## ASV0036     -5.917e+28  2.370e+21 -2.497e+07   <2e-16 ***
## ASV2125     -7.087e+28  1.664e+21 -4.260e+07   <2e-16 ***
## ASV1075      6.018e+27  2.045e+20  2.943e+07   <2e-16 ***
## ASV0390      9.085e+27  3.639e+20  2.497e+07   <2e-16 ***
## ASV3790     -5.568e+28  8.957e+20 -6.216e+07   <2e-16 ***
## ASV1535      2.383e+28  1.609e+21  1.482e+07   <2e-16 ***
## ASV0263             NA         NA         NA       NA    
## ASV0675     -2.318e+28  5.031e+20 -4.608e+07   <2e-16 ***
## ASV3348      3.898e+28  8.378e+20  4.652e+07   <2e-16 ***
## ASV0058     -5.412e+28  7.730e+20 -7.001e+07   <2e-16 ***
## ASV4142             NA         NA         NA       NA    
## ASV0059      2.588e+28  5.482e+20  4.721e+07   <2e-16 ***
## ASV0013      4.766e+28  8.565e+20  5.565e+07   <2e-16 ***
## ASV0033      2.746e+28  2.522e+21  1.089e+07   <2e-16 ***
## ASV4354             NA         NA         NA       NA    
## ASV0022     -2.089e+28  6.499e+20 -3.214e+07   <2e-16 ***
## ASV0134     -1.109e+29  1.289e+21 -8.605e+07   <2e-16 ***
## ASV0415     -2.927e+28  2.070e+21 -1.414e+07   <2e-16 ***
## ASV10103            NA         NA         NA       NA    
## ASV1613      1.578e+28  7.769e+20  2.031e+07   <2e-16 ***
## ASV0135      1.178e+28  5.454e+20  2.160e+07   <2e-16 ***
## ASV0469             NA         NA         NA       NA    
## ASV0471     -9.131e+27  1.614e+21 -5.657e+06   <2e-16 ***
## ASV0451      2.986e+27  1.646e+20  1.814e+07   <2e-16 ***
## ASV0747     -3.092e+28  1.159e+21 -2.667e+07   <2e-16 ***
## ASV1314     -4.147e+27  1.474e+20 -2.814e+07   <2e-16 ***
## ASV0425             NA         NA         NA       NA    
## ASV0559      6.903e+28  1.973e+21  3.499e+07   <2e-16 ***
## ASV0148      1.459e+28  2.220e+20  6.574e+07   <2e-16 ***
## ASV0129     -1.161e+28  2.881e+20 -4.030e+07   <2e-16 ***
## ASV1072      2.080e+28  5.765e+20  3.608e+07   <2e-16 ***
## ASV2390             NA         NA         NA       NA    
## ASV0548     -2.117e+28  5.239e+20 -4.040e+07   <2e-16 ***
## ASV0168     -2.354e+27  1.003e+20 -2.347e+07   <2e-16 ***
## ASV0066     -7.915e+26  1.385e+19 -5.713e+07   <2e-16 ***
## ASV0468     -1.625e+28  3.527e+20 -4.606e+07   <2e-16 ***
## ASV0172     -7.366e+27  3.894e+20 -1.892e+07   <2e-16 ***
## ASV0236      5.326e+28  9.392e+20  5.671e+07   <2e-16 ***
## ASV0250     -1.591e+27  2.347e+20 -6.780e+06   <2e-16 ***
## ASV0338     -3.099e+28  1.010e+21 -3.069e+07   <2e-16 ***
## ASV0450      1.120e+28  2.586e+20  4.329e+07   <2e-16 ***
## ASV0377             NA         NA         NA       NA    
## ASV1022     -1.071e+27  7.790e+19 -1.374e+07   <2e-16 ***
## ASV6174             NA         NA         NA       NA    
## ASV0786             NA         NA         NA       NA    
## ASV0053     -9.714e+27  5.353e+20 -1.815e+07   <2e-16 ***
## ASV0697     -5.380e+27  2.159e+20 -2.492e+07   <2e-16 ***
## ASV0785     -4.830e+27  2.254e+20 -2.143e+07   <2e-16 ***
## ASV1967     -8.431e+27  1.464e+20 -5.759e+07   <2e-16 ***
## ASV0385      1.474e+28  5.002e+20  2.946e+07   <2e-16 ***
## ASV0295      1.389e+27  1.013e+20  1.372e+07   <2e-16 ***
## ASV0072      5.593e+27  2.169e+20  2.578e+07   <2e-16 ***
## ASV0157     -6.235e+27  3.119e+20 -1.999e+07   <2e-16 ***
## ASV0501      3.135e+28  9.096e+20  3.446e+07   <2e-16 ***
## ASV10729     3.761e+28  6.635e+20  5.668e+07   <2e-16 ***
## ASV1470             NA         NA         NA       NA    
## ASV0050     -6.568e+28  2.073e+21 -3.169e+07   <2e-16 ***
## ASV0411      1.366e+28  4.640e+20  2.945e+07   <2e-16 ***
## ASV0549      2.699e+26  2.997e+20  9.008e+05   <2e-16 ***
## ASV0184      5.557e+24  2.707e+17  2.053e+07   <2e-16 ***
## ASV0705     -6.453e+27  1.620e+20 -3.983e+07   <2e-16 ***
## ASV1715     -9.149e+28  2.108e+21 -4.341e+07   <2e-16 ***
## ASV0603      5.191e+28  1.013e+21  5.122e+07   <2e-16 ***
## ASV0826             NA         NA         NA       NA    
## ASV0034      9.970e+27  3.544e+20  2.813e+07   <2e-16 ***
## ASV0838     -1.773e+28  3.285e+20 -5.398e+07   <2e-16 ***
## ASV0614      5.747e+27  2.326e+20  2.471e+07   <2e-16 ***
## ASV0014      1.223e+29  4.764e+21  2.566e+07   <2e-16 ***
## ASV0585             NA         NA         NA       NA    
## ASV0016     -3.690e+28  3.999e+21 -9.227e+06   <2e-16 ***
## ASV5394      5.135e+27  2.961e+20  1.734e+07   <2e-16 ***
## ASV0666             NA         NA         NA       NA    
## ASV2085             NA         NA         NA       NA    
## ASV0003     -1.319e+29  1.589e+21 -8.300e+07   <2e-16 ***
## ASV0346      1.742e+28  5.481e+20  3.178e+07   <2e-16 ***
## ASV0267     -2.282e+27  3.300e+20 -6.917e+06   <2e-16 ***
## ASV0353     -2.067e+28  7.269e+20 -2.844e+07   <2e-16 ***
## ASV2419      4.473e+28  7.625e+20  5.866e+07   <2e-16 ***
## ASV0447             NA         NA         NA       NA    
## ASV0654             NA         NA         NA       NA    
## ASV0151     -5.766e+27  9.188e+20 -6.275e+06   <2e-16 ***
## ASV0065      2.290e+28  3.993e+20  5.735e+07   <2e-16 ***
## ASV0527     -1.688e+28  4.697e+20 -3.593e+07   <2e-16 ***
## ASV4055             NA         NA         NA       NA    
## ASV0166             NA         NA         NA       NA    
## ASV0417      6.418e+27  2.235e+20  2.872e+07   <2e-16 ***
## ASV0078      5.592e+27  9.790e+19  5.712e+07   <2e-16 ***
## ASV0322             NA         NA         NA       NA    
## ASV0156     -2.195e+28  4.131e+20 -5.313e+07   <2e-16 ***
## ASV0648             NA         NA         NA       NA    
## ASV0407     -2.061e+27  1.004e+20 -2.053e+07   <2e-16 ***
## ASV2030             NA         NA         NA       NA    
## ASV0300     -6.594e+27  2.275e+20 -2.899e+07   <2e-16 ***
## ASV1150     -7.556e+27  3.360e+20 -2.249e+07   <2e-16 ***
## ASV0958     -1.517e+28  4.913e+20 -3.087e+07   <2e-16 ***
## ASV0216             NA         NA         NA       NA    
## ASV0446      3.140e+28  6.387e+20  4.917e+07   <2e-16 ***
## ASV0367             NA         NA         NA       NA    
## ASV0200             NA         NA         NA       NA    
## ASV0334             NA         NA         NA       NA    
## ASV1311             NA         NA         NA       NA    
## ASV0458             NA         NA         NA       NA    
## ASV1371             NA         NA         NA       NA    
## ASV0418             NA         NA         NA       NA    
## ASV0004      1.280e+28  2.243e+20  5.710e+07   <2e-16 ***
## ASV1943             NA         NA         NA       NA    
## ASV1495     -1.043e+27  3.707e+19 -2.814e+07   <2e-16 ***
## ASV0901             NA         NA         NA       NA    
## ASV0628             NA         NA         NA       NA    
## ASV0400             NA         NA         NA       NA    
## ASV0116             NA         NA         NA       NA    
## ASV0788             NA         NA         NA       NA    
## ASV0117      2.085e+27  3.652e+19  5.710e+07   <2e-16 ***
## ASV3137             NA         NA         NA       NA    
## ASV0001             NA         NA         NA       NA    
## ASV1651             NA         NA         NA       NA    
## ASV1692             NA         NA         NA       NA    
## ASV0660             NA         NA         NA       NA    
## ASV0508             NA         NA         NA       NA    
## ASV1660             NA         NA         NA       NA    
## ASV0233             NA         NA         NA       NA    
## ASV1343             NA         NA         NA       NA    
## ASV0209             NA         NA         NA       NA    
## ASV0193             NA         NA         NA       NA    
## ASV0357     -1.353e+28  7.875e+20 -1.718e+07   <2e-16 ***
## ASV0198             NA         NA         NA       NA    
## ASV0007             NA         NA         NA       NA    
## ASV1772             NA         NA         NA       NA    
## ASV0009             NA         NA         NA       NA    
## ASV0006             NA         NA         NA       NA    
## ASV0011             NA         NA         NA       NA    
## ASV0015             NA         NA         NA       NA    
## ASV0017             NA         NA         NA       NA    
## ASV0235             NA         NA         NA       NA    
## ASV0382             NA         NA         NA       NA    
## ASV2357             NA         NA         NA       NA    
## ASV0567             NA         NA         NA       NA    
## ASV0165             NA         NA         NA       NA    
## ASV0005             NA         NA         NA       NA    
## ASV0384             NA         NA         NA       NA    
## ASV0002             NA         NA         NA       NA    
## ASV3017             NA         NA         NA       NA    
## ASV0091             NA         NA         NA       NA    
## ASV0186             NA         NA         NA       NA    
## ASV0370             NA         NA         NA       NA    
## ASV0018             NA         NA         NA       NA    
## ASV1377             NA         NA         NA       NA    
## ASV0019             NA         NA         NA       NA    
## ASV0023             NA         NA         NA       NA    
## ASV2194             NA         NA         NA       NA    
## ASV1155             NA         NA         NA       NA    
## ASV0510             NA         NA         NA       NA    
## ASV2371             NA         NA         NA       NA    
## ASV0024             NA         NA         NA       NA    
## ASV2452             NA         NA         NA       NA    
## ASV2332             NA         NA         NA       NA    
## ASV2591             NA         NA         NA       NA    
## ASV0521             NA         NA         NA       NA    
## ASV5542             NA         NA         NA       NA    
## ASV0336             NA         NA         NA       NA    
## ASV10102            NA         NA         NA       NA    
## ASV16823            NA         NA         NA       NA    
## ASV3104             NA         NA         NA       NA    
## ASV0781             NA         NA         NA       NA    
## ASV10899            NA         NA         NA       NA    
## ASV11222            NA         NA         NA       NA    
## ASV11327            NA         NA         NA       NA    
## ASV12458            NA         NA         NA       NA    
## ASV1636             NA         NA         NA       NA    
## ASV1890             NA         NA         NA       NA    
## ASV2898             NA         NA         NA       NA    
## ASV8328             NA         NA         NA       NA    
## ASV0709             NA         NA         NA       NA    
## ASV0856             NA         NA         NA       NA    
## ASV0909             NA         NA         NA       NA    
## ASV0937             NA         NA         NA       NA    
## ASV11390            NA         NA         NA       NA    
## ASV11966            NA         NA         NA       NA    
## ASV12990            NA         NA         NA       NA    
## ASV14797            NA         NA         NA       NA    
## ASV14904            NA         NA         NA       NA    
## ASV15304            NA         NA         NA       NA    
## ASV16696            NA         NA         NA       NA    
## ASV1690             NA         NA         NA       NA    
## ASV2029             NA         NA         NA       NA    
## ASV2834             NA         NA         NA       NA    
## ASV4003             NA         NA         NA       NA    
## ASV4064             NA         NA         NA       NA    
## ASV4294             NA         NA         NA       NA    
## ASV4609             NA         NA         NA       NA    
## ASV6283             NA         NA         NA       NA    
## ASV6491             NA         NA         NA       NA    
## ASV7453             NA         NA         NA       NA    
## ASV7959             NA         NA         NA       NA    
## ASV8219             NA         NA         NA       NA    
## ASV8547             NA         NA         NA       NA    
## ASV9319             NA         NA         NA       NA    
## ASV9382             NA         NA         NA       NA    
## ASV11516            NA         NA         NA       NA    
## ASV14377            NA         NA         NA       NA    
## ASV1867             NA         NA         NA       NA    
## ASV1895             NA         NA         NA       NA    
## ASV3168             NA         NA         NA       NA    
## ASV4449             NA         NA         NA       NA    
## ASV6596             NA         NA         NA       NA    
## ASV7492             NA         NA         NA       NA    
## ASV9854             NA         NA         NA       NA    
## ASV6296             NA         NA         NA       NA    
## ASV4201             NA         NA         NA       NA    
## ASV0552             NA         NA         NA       NA    
## ASV3671             NA         NA         NA       NA    
## ASV3529             NA         NA         NA       NA    
## ASV1060             NA         NA         NA       NA    
## ASV0239             NA         NA         NA       NA    
## ASV5711             NA         NA         NA       NA    
## ASV4152             NA         NA         NA       NA    
## ASV1461             NA         NA         NA       NA    
## ASV2877             NA         NA         NA       NA    
## ASV0012             NA         NA         NA       NA    
## ASV9823             NA         NA         NA       NA    
## ASV0008             NA         NA         NA       NA    
## ASV7832             NA         NA         NA       NA    
## ASV1915             NA         NA         NA       NA    
## ASV0055             NA         NA         NA       NA    
## ASV0032             NA         NA         NA       NA    
## ASV2977             NA         NA         NA       NA    
## ASV0466             NA         NA         NA       NA    
## ASV3866             NA         NA         NA       NA    
## ASV0040             NA         NA         NA       NA    
## ASV0496             NA         NA         NA       NA    
## ASV0052             NA         NA         NA       NA    
## ASV3828             NA         NA         NA       NA    
## ASV1930             NA         NA         NA       NA    
## ASV2126             NA         NA         NA       NA    
## ASV0793             NA         NA         NA       NA    
## ASV0299             NA         NA         NA       NA    
## ASV0208             NA         NA         NA       NA    
## ASV0511             NA         NA         NA       NA    
## ASV1123             NA         NA         NA       NA    
## ASV0099             NA         NA         NA       NA    
## ASV0752             NA         NA         NA       NA    
## ASV0883             NA         NA         NA       NA    
## ASV0683             NA         NA         NA       NA    
## ASV4117             NA         NA         NA       NA    
## ASV2172             NA         NA         NA       NA    
## ASV0330             NA         NA         NA       NA    
## ASV0728             NA         NA         NA       NA    
## ASV0499             NA         NA         NA       NA    
## ASV0120             NA         NA         NA       NA    
## ASV1446             NA         NA         NA       NA    
## ASV17171            NA         NA         NA       NA    
## ASV0533             NA         NA         NA       NA    
## ASV2495             NA         NA         NA       NA    
## ASV5582             NA         NA         NA       NA    
## ASV1488             NA         NA         NA       NA    
## ASV0682             NA         NA         NA       NA    
## ASV0068             NA         NA         NA       NA    
## ASV1987             NA         NA         NA       NA    
## ASV0035             NA         NA         NA       NA    
## ASV7192             NA         NA         NA       NA    
## ASV0873             NA         NA         NA       NA    
## ASV4749             NA         NA         NA       NA    
## ASV2174             NA         NA         NA       NA    
## ASV1476             NA         NA         NA       NA    
## ASV0740             NA         NA         NA       NA    
## ASV0170             NA         NA         NA       NA    
## ASV2466             NA         NA         NA       NA    
## ASV1709             NA         NA         NA       NA    
## ASV6170             NA         NA         NA       NA    
## ASV3673             NA         NA         NA       NA    
## ASV1745             NA         NA         NA       NA    
## ASV0380      3.666e+28  6.178e+20  5.934e+07   <2e-16 ***
## ASV0426             NA         NA         NA       NA    
## ASV0202             NA         NA         NA       NA    
## ASV6350             NA         NA         NA       NA    
## ASV0713             NA         NA         NA       NA    
## ASV1822             NA         NA         NA       NA    
## ASV4569             NA         NA         NA       NA    
## ASV0030             NA         NA         NA       NA    
## ASV0331             NA         NA         NA       NA    
## ASV2981             NA         NA         NA       NA    
## ASV0828             NA         NA         NA       NA    
## ASV2440             NA         NA         NA       NA    
## ASV3006             NA         NA         NA       NA    
## ASV3875             NA         NA         NA       NA    
## ASV4511             NA         NA         NA       NA    
## ASV4700             NA         NA         NA       NA    
## ASV5804             NA         NA         NA       NA    
## ASV6826             NA         NA         NA       NA    
## ASV7280             NA         NA         NA       NA    
## ASV7535             NA         NA         NA       NA    
## ASV0651             NA         NA         NA       NA    
## ASV0913             NA         NA         NA       NA    
## ASV10832            NA         NA         NA       NA    
## ASV1117             NA         NA         NA       NA    
## ASV11329            NA         NA         NA       NA    
## ASV13209            NA         NA         NA       NA    
## ASV1345             NA         NA         NA       NA    
## ASV1719             NA         NA         NA       NA    
## ASV1886             NA         NA         NA       NA    
## ASV2158             NA         NA         NA       NA    
## ASV2189             NA         NA         NA       NA    
## ASV2257             NA         NA         NA       NA    
## ASV2283             NA         NA         NA       NA    
## ASV2328             NA         NA         NA       NA    
## ASV2434             NA         NA         NA       NA    
## ASV2648             NA         NA         NA       NA    
## ASV2698             NA         NA         NA       NA    
## ASV2775             NA         NA         NA       NA    
## ASV3171             NA         NA         NA       NA    
## ASV3227             NA         NA         NA       NA    
## ASV3397             NA         NA         NA       NA    
## ASV3444             NA         NA         NA       NA    
## ASV3556             NA         NA         NA       NA    
## ASV3606             NA         NA         NA       NA    
## ASV4190             NA         NA         NA       NA    
## ASV4197             NA         NA         NA       NA    
## ASV4722             NA         NA         NA       NA    
## ASV4765             NA         NA         NA       NA    
## ASV4809             NA         NA         NA       NA    
## ASV4846             NA         NA         NA       NA    
## ASV4903             NA         NA         NA       NA    
## ASV4944             NA         NA         NA       NA    
## ASV5151             NA         NA         NA       NA    
## ASV5413             NA         NA         NA       NA    
## ASV5537             NA         NA         NA       NA    
## ASV5688             NA         NA         NA       NA    
## ASV5752             NA         NA         NA       NA    
## ASV6122             NA         NA         NA       NA    
## ASV6135             NA         NA         NA       NA    
## ASV6188             NA         NA         NA       NA    
## ASV6216             NA         NA         NA       NA    
## ASV6242             NA         NA         NA       NA    
## ASV6383             NA         NA         NA       NA    
## ASV6781             NA         NA         NA       NA    
## ASV6799             NA         NA         NA       NA    
## ASV7374             NA         NA         NA       NA    
## ASV7539             NA         NA         NA       NA    
## ASV8591             NA         NA         NA       NA    
## ASV8637             NA         NA         NA       NA    
## ASV12796            NA         NA         NA       NA    
## ASV1934             NA         NA         NA       NA    
## ASV22549            NA         NA         NA       NA    
## ASV29857            NA         NA         NA       NA    
## ASV3215             NA         NA         NA       NA    
## ASV3236             NA         NA         NA       NA    
## ASV3954             NA         NA         NA       NA    
## ASV4850             NA         NA         NA       NA    
## ASV5225             NA         NA         NA       NA    
## ASV5532             NA         NA         NA       NA    
## ASV7258             NA         NA         NA       NA    
## ASV9474             NA         NA         NA       NA    
## ASV11857            NA         NA         NA       NA    
## ASV1202             NA         NA         NA       NA    
## ASV14742            NA         NA         NA       NA    
## ASV16652            NA         NA         NA       NA    
## ASV2019             NA         NA         NA       NA    
## ASV2410             NA         NA         NA       NA    
## ASV2718             NA         NA         NA       NA    
## ASV2738             NA         NA         NA       NA    
## ASV2876             NA         NA         NA       NA    
## ASV3177             NA         NA         NA       NA    
## ASV4367             NA         NA         NA       NA    
## ASV4635             NA         NA         NA       NA    
## ASV4896             NA         NA         NA       NA    
## ASV4907             NA         NA         NA       NA    
## ASV5230             NA         NA         NA       NA    
## ASV6509             NA         NA         NA       NA    
## ASV7376             NA         NA         NA       NA    
## ASV8163             NA         NA         NA       NA    
## ASV8195             NA         NA         NA       NA    
## ASV8923             NA         NA         NA       NA    
## ASV9666             NA         NA         NA       NA    
## ASV1482             NA         NA         NA       NA    
## ASV2726             NA         NA         NA       NA    
## ASV3281             NA         NA         NA       NA    
## ASV4235             NA         NA         NA       NA    
## ASV4808             NA         NA         NA       NA    
## ASV4861             NA         NA         NA       NA    
## ASV5276             NA         NA         NA       NA    
## ASV5837             NA         NA         NA       NA    
## ASV7098             NA         NA         NA       NA    
## ASV8451             NA         NA         NA       NA    
## ASV8694             NA         NA         NA       NA    
## ASV0905             NA         NA         NA       NA    
## ASV2900             NA         NA         NA       NA    
## ASV3963             NA         NA         NA       NA    
## ASV0041             NA         NA         NA       NA    
## ASV1865             NA         NA         NA       NA    
## ASV1140             NA         NA         NA       NA    
## ASV1179             NA         NA         NA       NA    
## ASV0279             NA         NA         NA       NA    
## ASV0043             NA         NA         NA       NA    
## ASV2097             NA         NA         NA       NA    
## ASV0309             NA         NA         NA       NA    
## ASV0607             NA         NA         NA       NA    
## ASV0025             NA         NA         NA       NA    
## ASV2284             NA         NA         NA       NA    
## ASV0556             NA         NA         NA       NA    
## ASV5040             NA         NA         NA       NA    
## ASV2924             NA         NA         NA       NA    
## ASV1331             NA         NA         NA       NA    
## ASV0506             NA         NA         NA       NA    
## ASV1514             NA         NA         NA       NA    
## ASV2144             NA         NA         NA       NA    
## ASV2265             NA         NA         NA       NA    
## ASV5156             NA         NA         NA       NA    
## ASV5534             NA         NA         NA       NA    
## ASV5747             NA         NA         NA       NA    
## ASV6657             NA         NA         NA       NA    
## ASV0658             NA         NA         NA       NA    
## ASV0716             NA         NA         NA       NA    
## ASV1657             NA         NA         NA       NA    
## ASV1885             NA         NA         NA       NA    
## ASV2333             NA         NA         NA       NA    
## ASV3375             NA         NA         NA       NA    
## ASV4317             NA         NA         NA       NA    
## ASV9599             NA         NA         NA       NA    
## ASV0175     -1.051e+29  4.110e+21 -2.558e+07   <2e-16 ***
## ASV1032             NA         NA         NA       NA    
## ASV1235             NA         NA         NA       NA    
## ASV1262             NA         NA         NA       NA    
## ASV1320             NA         NA         NA       NA    
## ASV13797            NA         NA         NA       NA    
## ASV1491             NA         NA         NA       NA    
## ASV15014            NA         NA         NA       NA    
## ASV1510             NA         NA         NA       NA    
## ASV1551             NA         NA         NA       NA    
## ASV1919             NA         NA         NA       NA    
## ASV2114             NA         NA         NA       NA    
## ASV21486            NA         NA         NA       NA    
## ASV2448             NA         NA         NA       NA    
## ASV2589             NA         NA         NA       NA    
## ASV2608             NA         NA         NA       NA    
## ASV2786             NA         NA         NA       NA    
## ASV2827             NA         NA         NA       NA    
## ASV2872             NA         NA         NA       NA    
## ASV3125             NA         NA         NA       NA    
## ASV3247             NA         NA         NA       NA    
## ASV3451             NA         NA         NA       NA    
## ASV3465             NA         NA         NA       NA    
## ASV3809             NA         NA         NA       NA    
## ASV4006             NA         NA         NA       NA    
## ASV4046             NA         NA         NA       NA    
## ASV4938             NA         NA         NA       NA    
## ASV5435             NA         NA         NA       NA    
## ASV5605             NA         NA         NA       NA    
## ASV5635             NA         NA         NA       NA    
## ASV5743             NA         NA         NA       NA    
## ASV6627             NA         NA         NA       NA    
## ASV6785             NA         NA         NA       NA    
## ASV7368             NA         NA         NA       NA    
## ASV9118             NA         NA         NA       NA    
## ASV9135             NA         NA         NA       NA    
## ASV9435             NA         NA         NA       NA    
## ASV9671             NA         NA         NA       NA    
## ASV0387             NA         NA         NA       NA    
## ASV0454             NA         NA         NA       NA    
## ASV0751             NA         NA         NA       NA    
## ASV1081             NA         NA         NA       NA    
## ASV1332             NA         NA         NA       NA    
## ASV2659             NA         NA         NA       NA    
## ASV2979             NA         NA         NA       NA    
## ASV4184             NA         NA         NA       NA    
## ASV6198             NA         NA         NA       NA    
## ASV7454             NA         NA         NA       NA    
## ASV8198             NA         NA         NA       NA    
## ASV0855             NA         NA         NA       NA    
## ASV10092            NA         NA         NA       NA    
## ASV1532             NA         NA         NA       NA    
## ASV2553             NA         NA         NA       NA    
## ASV2741             NA         NA         NA       NA    
## ASV4095             NA         NA         NA       NA    
## ASV5295             NA         NA         NA       NA    
## ASV5787             NA         NA         NA       NA    
## ASV9455             NA         NA         NA       NA    
## ASV10879            NA         NA         NA       NA    
## ASV3997             NA         NA         NA       NA    
## ASV6760             NA         NA         NA       NA    
## ASV6990             NA         NA         NA       NA    
## ASV9560             NA         NA         NA       NA    
## ASV0220             NA         NA         NA       NA    
## ASV2518             NA         NA         NA       NA    
## ASV3615             NA         NA         NA       NA    
## ASV0075             NA         NA         NA       NA    
## ASV8070             NA         NA         NA       NA    
## ASV1658             NA         NA         NA       NA    
## ASV0773             NA         NA         NA       NA    
## ASV0799             NA         NA         NA       NA    
## ASV1839             NA         NA         NA       NA    
## ASV0265             NA         NA         NA       NA    
## ASV3741             NA         NA         NA       NA    
## ASV0847     -3.093e+28  1.878e+21 -1.647e+07   <2e-16 ***
## ASV1026             NA         NA         NA       NA    
## ASV1222             NA         NA         NA       NA    
## ASV0729             NA         NA         NA       NA    
## ASV0143             NA         NA         NA       NA    
## ASV1328             NA         NA         NA       NA    
## ASV9078             NA         NA         NA       NA    
## ASV0027             NA         NA         NA       NA    
## ASV0546             NA         NA         NA       NA    
## ASV1136             NA         NA         NA       NA    
## ASV3081             NA         NA         NA       NA    
## ASV0531             NA         NA         NA       NA    
## ASV2525             NA         NA         NA       NA    
## ASV1083             NA         NA         NA       NA    
## ASV0424             NA         NA         NA       NA    
## ASV0644             NA         NA         NA       NA    
## ASV6007             NA         NA         NA       NA    
## ASV0564             NA         NA         NA       NA    
## ASV1938             NA         NA         NA       NA    
## ASV6516             NA         NA         NA       NA    
## ASV0503             NA         NA         NA       NA    
## ASV6913             NA         NA         NA       NA    
## ASV0164             NA         NA         NA       NA    
## ASV1576             NA         NA         NA       NA    
## ASV1725             NA         NA         NA       NA    
## ASV4501             NA         NA         NA       NA    
## ASV10678            NA         NA         NA       NA    
## ASV0944             NA         NA         NA       NA    
## ASV2292             NA         NA         NA       NA    
## ASV1090             NA         NA         NA       NA    
## ASV9117             NA         NA         NA       NA    
## ASV0285             NA         NA         NA       NA    
## ASV0463             NA         NA         NA       NA    
## ASV3199             NA         NA         NA       NA    
## ASV0150             NA         NA         NA       NA    
## ASV6583             NA         NA         NA       NA    
## ASV0392             NA         NA         NA       NA    
## ASV14007            NA         NA         NA       NA    
## ASV0177             NA         NA         NA       NA    
## ASV6448             NA         NA         NA       NA    
## ASV5399             NA         NA         NA       NA    
## ASV0277             NA         NA         NA       NA    
## ASV2599             NA         NA         NA       NA    
## ASV13465            NA         NA         NA       NA    
## ASV2412             NA         NA         NA       NA    
## ASV0423             NA         NA         NA       NA    
## ASV5187             NA         NA         NA       NA    
## ASV0701             NA         NA         NA       NA    
## ASV4248             NA         NA         NA       NA    
## ASV0519             NA         NA         NA       NA    
## ASV0764             NA         NA         NA       NA    
## ASV5385             NA         NA         NA       NA    
## ASV3021             NA         NA         NA       NA    
## ASV4119             NA         NA         NA       NA    
## ASV2534             NA         NA         NA       NA    
## ASV1061             NA         NA         NA       NA    
## ASV0670             NA         NA         NA       NA    
## ASV1384             NA         NA         NA       NA    
## ASV1981             NA         NA         NA       NA    
## ASV9632             NA         NA         NA       NA    
## ASV4564             NA         NA         NA       NA    
## ASV5289             NA         NA         NA       NA    
## ASV0516             NA         NA         NA       NA    
## ASV1463             NA         NA         NA       NA    
## ASV0969             NA         NA         NA       NA    
## ASV1113             NA         NA         NA       NA    
## ASV1234             NA         NA         NA       NA    
## ASV3814             NA         NA         NA       NA    
## ASV1000             NA         NA         NA       NA    
## ASV0079             NA         NA         NA       NA    
## ASV0145     -2.142e+27  2.825e+20 -7.581e+06   <2e-16 ***
## ASV0457             NA         NA         NA       NA    
## ASV1485             NA         NA         NA       NA    
## ASV0535             NA         NA         NA       NA    
## ASV0259             NA         NA         NA       NA    
## ASV0570             NA         NA         NA       NA    
## ASV0906             NA         NA         NA       NA    
## ASV1748             NA         NA         NA       NA    
## ASV5520             NA         NA         NA       NA    
## ASV2288             NA         NA         NA       NA    
## ASV1887             NA         NA         NA       NA    
## ASV0374             NA         NA         NA       NA    
## ASV0823             NA         NA         NA       NA    
## ASV0717             NA         NA         NA       NA    
## ASV0431             NA         NA         NA       NA    
## ASV1030             NA         NA         NA       NA    
## ASV1082             NA         NA         NA       NA    
## ASV2684             NA         NA         NA       NA    
## ASV0051             NA         NA         NA       NA    
## ASV0513             NA         NA         NA       NA    
## ASV0581             NA         NA         NA       NA    
## ASV7282             NA         NA         NA       NA    
## ASV3009             NA         NA         NA       NA    
## ASV2106             NA         NA         NA       NA    
## ASV1012             NA         NA         NA       NA    
## ASV0921             NA         NA         NA       NA    
## ASV0010             NA         NA         NA       NA    
## ASV1178             NA         NA         NA       NA    
## ASV2848             NA         NA         NA       NA    
## ASV0586             NA         NA         NA       NA    
## ASV4225             NA         NA         NA       NA    
## ASV2156             NA         NA         NA       NA    
## ASV9778             NA         NA         NA       NA    
## ASV0493             NA         NA         NA       NA    
## ASV3770             NA         NA         NA       NA    
## ASV0470      1.465e+28  8.951e+20  1.636e+07   <2e-16 ***
## ASV0262             NA         NA         NA       NA    
## ASV0998             NA         NA         NA       NA    
## ASV7708             NA         NA         NA       NA    
## ASV0453             NA         NA         NA       NA    
## ASV0044             NA         NA         NA       NA    
## ASV5490             NA         NA         NA       NA    
## ASV2638             NA         NA         NA       NA    
## ASV0829             NA         NA         NA       NA    
## ASV0601             NA         NA         NA       NA    
## ASV0234             NA         NA         NA       NA    
## ASV0133             NA         NA         NA       NA    
## ASV0323             NA         NA         NA       NA    
## ASV0854             NA         NA         NA       NA    
## ASV0110             NA         NA         NA       NA    
## ASV0816             NA         NA         NA       NA    
## ASV1031             NA         NA         NA       NA    
## ASV0144     -4.842e+27  1.737e+20 -2.787e+07   <2e-16 ***
## ASV0020             NA         NA         NA       NA    
## ASV0962             NA         NA         NA       NA    
## ASV0794             NA         NA         NA       NA    
## ASV7117             NA         NA         NA       NA    
## ASV1008             NA         NA         NA       NA    
## ASV0096             NA         NA         NA       NA    
## ASV0128             NA         NA         NA       NA    
## ASV5232             NA         NA         NA       NA    
## ASV0031             NA         NA         NA       NA    
## ASV1744             NA         NA         NA       NA    
## ASV0289      1.756e+28  2.981e+20  5.890e+07   <2e-16 ***
## ASV7413             NA         NA         NA       NA    
## ASV0822             NA         NA         NA       NA    
## ASV8111             NA         NA         NA       NA    
## ASV0687             NA         NA         NA       NA    
## ASV0112             NA         NA         NA       NA    
## ASV0987             NA         NA         NA       NA    
## ASV5332             NA         NA         NA       NA    
## ASV1129             NA         NA         NA       NA    
## ASV1274             NA         NA         NA       NA    
## ASV0119             NA         NA         NA       NA    
## ASV0890      5.182e+27  3.372e+20  1.537e+07   <2e-16 ***
## ASV0848             NA         NA         NA       NA    
## ASV5944             NA         NA         NA       NA    
## ASV19741            NA         NA         NA       NA    
## ASV0504             NA         NA         NA       NA    
## ASV2146             NA         NA         NA       NA    
## ASV0089             NA         NA         NA       NA    
## ASV2301             NA         NA         NA       NA    
## ASV2982             NA         NA         NA       NA    
## ASV0891             NA         NA         NA       NA    
## ASV0093             NA         NA         NA       NA    
## ASV0042      1.376e+28  3.824e+20  3.598e+07   <2e-16 ***
## ASV0980             NA         NA         NA       NA    
## ASV0069             NA         NA         NA       NA    
## ASV1364             NA         NA         NA       NA    
## ASV0524             NA         NA         NA       NA    
## ASV0435             NA         NA         NA       NA    
## ASV0517             NA         NA         NA       NA    
## ASV3167             NA         NA         NA       NA    
## ASV4280             NA         NA         NA       NA    
## ASV1158             NA         NA         NA       NA    
## ASV2214             NA         NA         NA       NA    
## ASV0544             NA         NA         NA       NA    
## ASV5326             NA         NA         NA       NA    
## ASV3765             NA         NA         NA       NA    
## ASV4646             NA         NA         NA       NA    
## ASV0090             NA         NA         NA       NA    
## ASV3680             NA         NA         NA       NA    
## ASV0111     -4.489e+27  4.914e+20 -9.136e+06   <2e-16 ***
## ASV0768             NA         NA         NA       NA    
## ASV4862             NA         NA         NA       NA    
## ASV1742             NA         NA         NA       NA    
## ASV3701             NA         NA         NA       NA    
## ASV2386             NA         NA         NA       NA    
## ASV0375             NA         NA         NA       NA    
## ASV2796             NA         NA         NA       NA    
## ASV1369             NA         NA         NA       NA    
## ASV10272            NA         NA         NA       NA    
## ASV10354            NA         NA         NA       NA    
## ASV1067             NA         NA         NA       NA    
## ASV1900             NA         NA         NA       NA    
## ASV4079             NA         NA         NA       NA    
## ASV4149             NA         NA         NA       NA    
## ASV5140             NA         NA         NA       NA    
## ASV10782            NA         NA         NA       NA    
## ASV4273             NA         NA         NA       NA    
## ASV8121             NA         NA         NA       NA    
## ASV8438             NA         NA         NA       NA    
## ASV9390             NA         NA         NA       NA    
## ASV1340             NA         NA         NA       NA    
## ASV2650             NA         NA         NA       NA    
## ASV4674             NA         NA         NA       NA    
## ASV10492            NA         NA         NA       NA    
## ASV11430            NA         NA         NA       NA    
## ASV12135            NA         NA         NA       NA    
## ASV14970            NA         NA         NA       NA    
## ASV1954             NA         NA         NA       NA    
## ASV2613             NA         NA         NA       NA    
## ASV2757             NA         NA         NA       NA    
## ASV2909             NA         NA         NA       NA    
## ASV2954             NA         NA         NA       NA    
## ASV2969             NA         NA         NA       NA    
## ASV3410             NA         NA         NA       NA    
## ASV3575             NA         NA         NA       NA    
## ASV4275             NA         NA         NA       NA    
## ASV4652             NA         NA         NA       NA    
## ASV4761             NA         NA         NA       NA    
## ASV6003             NA         NA         NA       NA    
## ASV6110             NA         NA         NA       NA    
## ASV7427             NA         NA         NA       NA    
## ASV8092             NA         NA         NA       NA    
## ASV8169             NA         NA         NA       NA    
## ASV9693             NA         NA         NA       NA    
## ASV10913            NA         NA         NA       NA    
## ASV1979             NA         NA         NA       NA    
## ASV3772             NA         NA         NA       NA    
## ASV0113             NA         NA         NA       NA    
## ASV1800             NA         NA         NA       NA    
## ASV2335             NA         NA         NA       NA    
## ASV0692             NA         NA         NA       NA    
## ASV1120             NA         NA         NA       NA    
## ASV1434             NA         NA         NA       NA    
## ASV0076             NA         NA         NA       NA    
## ASV0361             NA         NA         NA       NA    
## ASV2231     -5.292e+27  2.547e+20 -2.078e+07   <2e-16 ***
## ASV2018             NA         NA         NA       NA    
## ASV1529             NA         NA         NA       NA    
## ASV0841             NA         NA         NA       NA    
## ASV2556             NA         NA         NA       NA    
## ASV2777             NA         NA         NA       NA    
## ASV0355             NA         NA         NA       NA    
## ASV5169             NA         NA         NA       NA    
## ASV3091             NA         NA         NA       NA    
## ASV2435             NA         NA         NA       NA    
## ASV6822             NA         NA         NA       NA    
## ASV12605            NA         NA         NA       NA    
## ASV0286             NA         NA         NA       NA    
## ASV0074             NA         NA         NA       NA    
## ASV2485             NA         NA         NA       NA    
## ASV1233             NA         NA         NA       NA    
## ASV0356             NA         NA         NA       NA    
## ASV2918             NA         NA         NA       NA    
## ASV1427             NA         NA         NA       NA    
## ASV1409             NA         NA         NA       NA    
## ASV0770             NA         NA         NA       NA    
## ASV1403             NA         NA         NA       NA    
## ASV0314             NA         NA         NA       NA    
## ASV0187             NA         NA         NA       NA    
## ASV0313             NA         NA         NA       NA    
## ASV1087             NA         NA         NA       NA    
## ASV1970             NA         NA         NA       NA    
## ASV0754             NA         NA         NA       NA    
## ASV3775             NA         NA         NA       NA    
## ASV0132             NA         NA         NA       NA    
## ASV2329             NA         NA         NA       NA    
## ASV0561             NA         NA         NA       NA    
## ASV0130             NA         NA         NA       NA    
## ASV0226             NA         NA         NA       NA    
## ASV12648            NA         NA         NA       NA    
## ASV0204             NA         NA         NA       NA    
## ASV0767             NA         NA         NA       NA    
## ASV0335             NA         NA         NA       NA    
## ASV5901     -3.411e+28  6.463e+20 -5.278e+07   <2e-16 ***
## ASV0596             NA         NA         NA       NA    
## ASV9271             NA         NA         NA       NA    
## ASV0904             NA         NA         NA       NA    
## ASV15270            NA         NA         NA       NA    
## ASV0990             NA         NA         NA       NA    
## ASV0155             NA         NA         NA       NA    
## ASV0086             NA         NA         NA       NA    
## ASV2581             NA         NA         NA       NA    
## ASV1579             NA         NA         NA       NA    
## ASV7730             NA         NA         NA       NA    
## ASV0897             NA         NA         NA       NA    
## ASV1975             NA         NA         NA       NA    
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
## (Dispersion parameter for binomial family taken to be 1)
## 
##     Null deviance:  385.39  on 277  degrees of freedom
## Residual deviance: 4974.02  on  33  degrees of freedom
## AIC: 5464
## 
## Number of Fisher Scoring iterations: 14
pchisq(logreg_1000$null.deviance, logreg_1000$df.null, lower.tail = FALSE)
## [1] 1.735332e-05
  • The above statistical test indicates that there is evidence for the alternative hypothesis that the model with predictors is much better than the null model with the intercept.
# Bad fit in notes example had a p-value of 0.9995629 from Ressler
# good fit would be the opposite
pchisq(logreg_1000$deviance, logreg_1000$df.residual, lower.tail = FALSE)
## [1] 0

Using top 500 ASVs to see if the model improves

lr_clr_df %>% 
  select(1:502) -> lr_clr_df_500 # because of id column and response column

dim(lr_clr_df_500)
## [1] 278 502

Logistic with Reduced 500 ASVs

glmnet::glmnet

y = as.factor(lr_clr_df_500$Clade)
x = as.matrix(lr_clr_df_500[,-c(1,2)])

glimpse(y)
##  Factor w/ 2 levels "0","1": 2 1 2 1 1 1 1 1 2 1 ...
dim(x)
## [1] 278 500
library(glmnet)
lr_model_500 <- glmnet(x, y, 
                        family = "binomial", 
                        #alpha = 1 ,# lasso L1 norm
                        alpha = 0 # ridge L2 norm
                )
lr_model_500
## 
## Call:  glmnet(x = x, y = y, family = "binomial", alpha = 0) 
## 
##      Df  %Dev  Lambda
## 1   500  0.00 161.800
## 2   500  0.66 154.400
## 3   500  0.69 147.400
## 4   500  0.72 140.700
## 5   500  0.76 134.300
## 6   500  0.79 128.200
## 7   500  0.83 122.400
## 8   500  0.86 116.800
## 9   500  0.90 111.500
## 10  500  0.95 106.500
## 11  500  0.99 101.600
## 12  500  1.03  96.990
## 13  500  1.08  92.590
## 14  500  1.13  88.380
## 15  500  1.18  84.360
## 16  500  1.23  80.530
## 17  500  1.29  76.870
## 18  500  1.35  73.370
## 19  500  1.41  70.040
## 20  500  1.47  66.850
## 21  500  1.54  63.820
## 22  500  1.60  60.920
## 23  500  1.67  58.150
## 24  500  1.75  55.500
## 25  500  1.82  52.980
## 26  500  1.90  50.570
## 27  500  1.99  48.270
## 28  500  2.07  46.080
## 29  500  2.16  43.990
## 30  500  2.26  41.990
## 31  500  2.35  40.080
## 32  500  2.45  38.260
## 33  500  2.56  36.520
## 34  500  2.67  34.860
## 35  500  2.78  33.270
## 36  500  2.90  31.760
## 37  500  3.02  30.320
## 38  500  3.14  28.940
## 39  500  3.27  27.620
## 40  500  3.41  26.370
## 41  500  3.54  25.170
## 42  500  3.69  24.030
## 43  500  3.84  22.930
## 44  500  3.99  21.890
## 45  500  4.15  20.900
## 46  500  4.31  19.950
## 47  500  4.48  19.040
## 48  500  4.66  18.180
## 49  500  4.84  17.350
## 50  500  5.02  16.560
## 51  500  5.22  15.810
## 52  500  5.41  15.090
## 53  500  5.62  14.400
## 54  500  5.83  13.750
## 55  500  6.04  13.120
## 56  500  6.27  12.530
## 57  500  6.49  11.960
## 58  500  6.73  11.410
## 59  500  6.97  10.900
## 60  500  7.22  10.400
## 61  500  7.47   9.928
## 62  500  7.73   9.476
## 63  500  8.00   9.046
## 64  500  8.25   8.635
## 65  500  8.53   8.242
## 66  500  8.82   7.868
## 67  500  9.11   7.510
## 68  500  9.41   7.169
## 69  500  9.72   6.843
## 70  500 10.04   6.532
## 71  500 10.36   6.235
## 72  500 10.69   5.952
## 73  500 11.02   5.681
## 74  500 11.36   5.423
## 75  500 11.71   5.176
## 76  500 12.07   4.941
## 77  500 12.43   4.716
## 78  500 12.80   4.502
## 79  500 13.18   4.297
## 80  500 13.57   4.102
## 81  500 13.96   3.916
## 82  500 14.36   3.738
## 83  500 14.76   3.568
## 84  500 15.17   3.406
## 85  500 15.59   3.251
## 86  500 16.02   3.103
## 87  500 16.45   2.962
## 88  500 16.89   2.827
## 89  500 17.33   2.699
## 90  500 17.78   2.576
## 91  500 18.24   2.459
## 92  500 18.70   2.347
## 93  500 19.17   2.241
## 94  500 19.64   2.139
## 95  500 20.12   2.042
## 96  500 20.61   1.949
## 97  500 21.10   1.860
## 98  500 21.60   1.776
## 99  500 22.10   1.695
## 100 500 22.60   1.618
summary(lr_model_500)
##            Length Class     Mode     
## a0           100  -none-    numeric  
## beta       50000  dgCMatrix S4       
## df           100  -none-    numeric  
## dim            2  -none-    numeric  
## lambda       100  -none-    numeric  
## dev.ratio    100  -none-    numeric  
## nulldev        1  -none-    numeric  
## npasses        1  -none-    numeric  
## jerr           1  -none-    numeric  
## offset         1  -none-    logical  
## classnames     2  -none-    character
## call           5  -none-    call     
## nobs           1  -none-    numeric
plot(lr_model_500)

#plot(lr_model_500, xlim = c(0, 50), ylim = c(-0.02, 0.02))

Cross-Validation

cv_results_500 <- cv.glmnet(x, y,
                        family = "binomial",
                        nfolds = 10)
plot(cv_results_500)

best_lambda_500 <- lr_model_500$lambda.min

# Refit the model with the selected lambda
best_model_500 <- glmnet(x, y, family = "binomial", alpha = 0, lambda = best_lambda_500)

coefficients(best_model_500)
## 501 x 100 sparse Matrix of class "dgCMatrix"
##   [[ suppressing 100 column names 's0', 's1', 's2' ... ]]
##                                                                    
## (Intercept) -1.249001e-16 -1.041408e-06 -1.187762e-06 -1.360009e-06
## ASV1236      3.133071e-38  1.946835e-04  2.039368e-04  2.133395e-04
## ASV0421     -5.547569e-38 -3.458000e-04 -3.622454e-04 -3.789858e-04
## ASV0691     -4.924975e-38 -3.028297e-04 -3.172243e-04 -3.316691e-04
## ASV0899     -1.324028e-39 -5.452944e-06 -5.703335e-06 -5.819708e-06
## ASV1004      6.299724e-38  3.929472e-04  4.116189e-04  4.306578e-04
## ASV1041     -4.258951e-38 -2.659067e-04 -2.785359e-04 -2.914339e-04
## ASV1058      5.855981e-38  3.652796e-04  3.826041e-04  4.003005e-04
## ASV12542     1.842670e-38  1.129563e-04  1.183282e-04  1.236954e-04
## ASV1294      6.764978e-38  4.239201e-04  4.440486e-04  4.646924e-04
## ASV13113     2.351661e-38  1.508735e-04  1.580489e-04  1.655781e-04
## ASV1318      5.929751e-38  3.701616e-04  3.877321e-04  4.056877e-04
## ASV2269     -1.761531e-38 -1.102015e-04 -1.154147e-04 -1.207775e-04
## ASV2542      3.703376e-38  2.361319e-04  2.473402e-04  2.590532e-04
## ASV2660     -3.447239e-38 -2.139622e-04 -2.240865e-04 -2.344023e-04
## ASV2737     -1.456066e-39 -1.059467e-05 -1.105923e-05 -1.165538e-05
## ASV2840      4.606802e-38  2.850893e-04  2.985949e-04  3.122855e-04
## ASV3053      2.609821e-39  1.563830e-05  1.638669e-05  1.710510e-05
## ASV3077      1.430712e-38  8.869862e-05  9.289707e-05  9.716039e-05
## ASV3134      4.753922e-38  3.041846e-04  3.186531e-04  3.337929e-04
## ASV3140      2.100119e-38  1.338102e-04  1.401451e-04  1.467805e-04
## ASV3579      7.918462e-39  5.290693e-05  5.545575e-05  5.820087e-05
## ASV6119     -1.761531e-38 -1.102014e-04 -1.153976e-04 -1.207588e-04
## ASV7557     -1.761531e-38 -1.102013e-04 -1.153888e-04 -1.207493e-04
## ASV8422      1.007031e-38  6.165407e-05  6.462866e-05  6.755334e-05
## ASV1086     -5.080525e-39 -3.102574e-05 -3.249795e-05 -3.396071e-05
## ASV1310      3.341700e-38  2.096597e-04  2.196185e-04  2.298383e-04
## ASV15750    -8.427200e-39 -5.237437e-05 -5.481547e-05 -5.734643e-05
## ASV16905    -1.761531e-38 -1.102012e-04 -1.153858e-04 -1.207457e-04
## ASV2033      3.219968e-38  2.059112e-04  2.157340e-04  2.259757e-04
## ASV2089      1.201683e-38  7.539107e-05  7.893577e-05  8.261583e-05
## ASV2127      4.826544e-38  3.016939e-04  3.160028e-04  3.306542e-04
## ASV2725      5.527505e-38  3.425367e-04  3.588048e-04  3.752820e-04
## ASV2804     -1.761531e-38 -1.102012e-04 -1.153836e-04 -1.207432e-04
## ASV3075      3.447315e-38  2.162683e-04  2.265464e-04  2.370909e-04
## ASV3327      3.161305e-38  2.013935e-04  2.110054e-04  2.209837e-04
## ASV3342      3.467863e-38  2.198175e-04  2.302377e-04  2.410757e-04
## ASV3532     -3.132836e-38 -1.984202e-04 -2.077995e-04 -2.175746e-04
## ASV3600      3.984828e-38  2.517166e-04  2.637003e-04  2.760617e-04
## ASV4013      3.390601e-38  2.123284e-04  2.224141e-04  2.327439e-04
## ASV4136      3.397772e-38  2.112234e-04  2.212088e-04  2.314084e-04
## ASV4195      1.761531e-38  1.102011e-04  1.153710e-04  1.207295e-04
## ASV4407     -1.761531e-38 -1.102011e-04 -1.153623e-04 -1.207200e-04
## ASV4717      1.290371e-39  6.638663e-06  7.018005e-06  7.265575e-06
## ASV6794      1.867634e-38  1.145782e-04  1.200565e-04  1.255079e-04
## ASV8324     -1.761531e-38 -1.102010e-04 -1.153605e-04 -1.207175e-04
## ASV8981     -5.080524e-39 -3.019982e-05 -3.155290e-05 -3.293736e-05
## ASV9859      1.271657e-38  8.320027e-05  8.721343e-05  9.145017e-05
## ASV0936     -2.763764e-38 -1.729459e-04 -1.811844e-04 -1.895901e-04
## ASV12683    -2.597726e-39 -1.740138e-05 -1.817968e-05 -1.908670e-05
## ASV1293      4.103429e-38  2.557504e-04  2.678398e-04  2.802220e-04
## ASV13055    -4.412996e-39 -2.712553e-05 -2.833222e-05 -2.962465e-05
## ASV17063    -1.761531e-38 -1.102009e-04 -1.153452e-04 -1.207008e-04
## ASV2228      1.761531e-38  1.102009e-04  1.153365e-04  1.206913e-04
## ASV2769     -3.595451e-39 -2.097337e-05 -2.188060e-05 -2.281922e-05
## ASV2803      8.703816e-39  5.297709e-05  5.555197e-05  5.805013e-05
## ASV2896      2.186891e-38  1.380459e-04  1.446501e-04  1.514268e-04
## ASV3062      6.184777e-39  4.135702e-05  4.339832e-05  4.554970e-05
## ASV3107      2.630824e-38  1.662676e-04  1.741901e-04  1.823594e-04
## ASV3265      5.341940e-38  3.327030e-04  3.484348e-04  3.645237e-04
## ASV3666     -1.114465e-39 -7.451771e-06 -7.735726e-06 -8.123044e-06
## ASV4497      1.264747e-38  7.875520e-05  8.254192e-05  8.634958e-05
## ASV6914     -6.022177e-39 -3.840633e-05 -4.016566e-05 -4.207069e-05
## ASV0576     -6.389199e-38 -3.941733e-04 -4.128451e-04 -4.317134e-04
## ASV0673      1.553071e-38  1.005599e-04  1.053368e-04  1.103996e-04
## ASV0772      1.888544e-38  1.185841e-04  1.242411e-04  1.300264e-04
## ASV0862     -1.577283e-38 -9.624201e-05 -1.007811e-04 -1.053257e-04
## ASV0898      1.494744e-38  9.690626e-05  1.015252e-04  1.064163e-04
## ASV0910      3.275872e-38  2.102763e-04  2.202774e-04  2.307769e-04
## ASV0964     -2.301490e-38 -1.425616e-04 -1.493006e-04 -1.561496e-04
## ASV10059     1.525478e-38  9.819790e-05  1.029093e-04  1.078277e-04
## ASV10263    -1.761531e-38 -1.102007e-04 -1.153853e-04 -1.207428e-04
## ASV1088      1.737606e-38  1.116371e-04  1.169575e-04  1.225406e-04
## ASV1101      3.039775e-38  1.911419e-04  2.001944e-04  2.095307e-04
## ASV1183      1.927595e-38  1.219949e-04  1.277442e-04  1.337485e-04
## ASV11956     8.034700e-39  4.841974e-05  5.074808e-05  5.300520e-05
## ASV12774    -2.459980e-39 -1.631997e-05 -1.706062e-05 -1.790378e-05
## ASV1321      7.011807e-39  4.743080e-05  4.973275e-05  5.222524e-05
## ASV13793    -1.761531e-38 -1.102007e-04 -1.153754e-04 -1.207318e-04
## ASV14482    -1.373377e-39 -9.725543e-06 -1.015634e-05 -1.068876e-05
## ASV15483     1.217911e-38  7.723984e-05  8.095984e-05  8.476968e-05
## ASV2062      7.731123e-38  4.861818e-04  5.091720e-04  5.329291e-04
## ASV2132      3.470506e-38  2.204742e-04  2.309960e-04  2.418904e-04
## ASV2413      5.051081e-38  3.151927e-04  3.300916e-04  3.453642e-04
## ASV2490      3.356463e-38  2.079765e-04  2.177842e-04  2.277848e-04
## ASV2594      1.808116e-38  1.136191e-04  1.190139e-04  1.245618e-04
## ASV2822     -1.761531e-38 -1.102007e-04 -1.153900e-04 -1.207473e-04
## ASV2863      3.096232e-38  1.927090e-04  2.017708e-04  2.110841e-04
## ASV2910      4.045912e-38  2.513272e-04  2.632667e-04  2.753882e-04
## ASV2980      1.459677e-38  9.099828e-05  9.526817e-05  9.967463e-05
## ASV3307      1.761531e-38  1.102006e-04  1.153755e-04  1.207314e-04
## ASV3474      2.664464e-38  1.712987e-04  1.794682e-04  1.880357e-04
## ASV3502      5.699692e-38  3.588708e-04  3.758956e-04  3.934573e-04
## ASV4236      2.952451e-38  1.830320e-04  1.916124e-04  2.004106e-04
## ASV4842     -9.516024e-39 -5.999834e-05 -6.282871e-05 -6.577126e-05
## ASV4894     -1.761531e-38 -1.102006e-04 -1.153855e-04 -1.207423e-04
## ASV5290      2.150314e-38  1.354662e-04  1.419307e-04  1.485652e-04
## ASV5501      4.076922e-39  2.546688e-05  2.667020e-05  2.790252e-05
## ASV5795      1.425114e-38  9.092280e-05  9.525718e-05  9.976722e-05
## ASV5987     -1.761531e-38 -1.102006e-04 -1.153889e-04 -1.207460e-04
## ASV6267     -1.761531e-38 -1.102006e-04 -1.153801e-04 -1.207365e-04
## ASV6862      3.472093e-38  2.139777e-04  2.240865e-04  2.343159e-04
## ASV7145      6.514140e-39  3.952594e-05  4.138615e-05  4.324086e-05
## ASV7673     -1.761531e-38 -1.102006e-04 -1.153780e-04 -1.207340e-04
## ASV7789      5.781709e-39  3.905618e-05  4.096668e-05  4.301725e-05
## ASV7809     -2.504185e-39 -1.418550e-05 -1.480008e-05 -1.541136e-05
## ASV8002     -1.761531e-38 -1.102005e-04 -1.153710e-04 -1.207266e-04
## ASV8205      1.018531e-38  6.404023e-05  6.713303e-05  7.026445e-05
## ASV9155     -1.330777e-38 -8.308357e-05 -8.696285e-05 -9.099100e-05
## ASV9221     -2.388223e-39 -1.325557e-05 -1.381260e-05 -1.436629e-05
## ASV9311     -1.761531e-38 -1.102005e-04 -1.153592e-04 -1.207137e-04
## ASV9557     -1.761531e-38 -1.102005e-04 -1.153505e-04 -1.207041e-04
## ASV9936     -1.761531e-38 -1.102005e-04 -1.153418e-04 -1.206946e-04
## ASV1445      3.997197e-38  2.534964e-04  2.655666e-04  2.780683e-04
## ASV4232      3.338541e-38  2.135401e-04  2.237365e-04  2.343650e-04
## ASV6479     -8.157800e-40 -2.075860e-06 -2.104403e-06 -2.044495e-06
## ASV0142     -9.010265e-38 -5.595826e-04 -5.860089e-04 -6.129847e-04
## ASV0378     -2.984397e-38 -1.839767e-04 -1.926313e-04 -2.014226e-04
## ASV1122      5.277825e-38  3.349845e-04  3.508960e-04  3.674281e-04
## ASV0123     -8.831622e-38 -5.483120e-04 -5.741572e-04 -6.005769e-04
## ASV2064      9.456684e-39  5.735524e-05  6.002163e-05  6.270867e-05
## ASV4459     -9.719539e-39 -6.054082e-05 -6.338198e-05 -6.631182e-05
## ASV0448      1.423142e-38  9.421691e-05  9.876856e-05  1.036272e-04
## ASV0397      3.967868e-38  2.507260e-04  2.626534e-04  2.749752e-04
## ASV0485      5.602948e-38  3.518069e-04  3.684630e-04  3.856311e-04
## ASV1566      4.654943e-38  2.939236e-04  3.078489e-04  3.222726e-04
## ASV1365      3.010399e-38  1.903257e-04  1.993754e-04  2.087295e-04
## ASV1065      6.170416e-38  3.899635e-04  4.084188e-04  4.275775e-04
## ASV0722     -1.470608e-39 -8.408869e-06 -8.817738e-06 -9.184343e-06
## ASV12660    -2.979446e-38 -1.845255e-04 -1.932216e-04 -2.020925e-04
## ASV0223     -1.235827e-39 -7.434295e-06 -7.790244e-06 -8.133094e-06
## ASV0229      2.730513e-38  1.738682e-04  1.821279e-04  1.907420e-04
## ASV0877     -1.108271e-38 -6.762417e-05 -7.071339e-05 -7.390467e-05
## ASV0983      5.740917e-38  3.595588e-04  3.765378e-04  3.940313e-04
## ASV0626     -1.988713e-38 -1.199933e-04 -1.255101e-04 -1.311011e-04
## ASV4146     -3.218327e-39 -1.993357e-05 -2.078466e-05 -2.173876e-05
## ASV4175     -3.481381e-38 -2.198452e-04 -2.301782e-04 -2.409660e-04
## ASV2082     -2.075558e-39 -1.508225e-05 -1.593355e-05 -1.678569e-05
## ASV2272      2.490583e-38  1.582824e-04  1.658332e-04  1.736581e-04
## ASV2245     -3.017452e-38 -1.912401e-04 -2.002133e-04 -2.096318e-04
## ASV0590     -1.761143e-38 -1.149942e-04 -1.205530e-04 -1.264001e-04
## ASV0217     -3.047970e-38 -1.815986e-04 -1.900350e-04 -1.983746e-04
## ASV0416      2.949399e-38  1.806468e-04  1.891050e-04  1.976779e-04
## ASV1056      3.274151e-38  2.107278e-04  2.208462e-04  2.314033e-04
## ASV7777     -3.002033e-38 -1.897346e-04 -1.986289e-04 -2.079458e-04
## ASV0455      5.747357e-39  3.781383e-05  3.953295e-05  4.146258e-05
## ASV0604      5.799389e-39  4.011724e-05  4.214501e-05  4.430247e-05
## ASV6100     -2.766616e-38 -1.751332e-04 -1.833354e-04 -1.919491e-04
## ASV11359    -3.118370e-38 -1.964049e-04 -2.055929e-04 -2.151996e-04
## ASV6604      2.173846e-38  1.386025e-04  1.452554e-04  1.521335e-04
## ASV5004     -1.832224e-38 -1.153461e-04 -1.206869e-04 -1.263227e-04
## ASV1483     -1.683076e-38 -1.062846e-04 -1.112159e-04 -1.164264e-04
## ASV9773     -3.550227e-38 -2.244712e-04 -2.349787e-04 -2.460033e-04
## ASV4059      2.938087e-39  2.059261e-05  2.165197e-05  2.277407e-05
## ASV1193      5.793652e-38  3.654317e-04  3.827843e-04  4.007021e-04
## ASV4610     -6.006542e-39 -3.361376e-05 -3.510839e-05 -3.653048e-05
## ASV0742     -2.298570e-38 -1.390926e-04 -1.454799e-04 -1.519809e-04
## ASV1502      8.007334e-41 -1.489656e-06 -1.502853e-06 -1.675768e-06
## ASV0195     -5.832160e-39 -3.932767e-05 -4.125131e-05 -4.331309e-05
## ASV1213      1.900259e-38  1.170458e-04  1.224024e-04  1.279818e-04
## ASV1648     -2.634404e-38 -1.662738e-04 -1.740302e-04 -1.821799e-04
## ASV6984     -1.961126e-38 -1.243064e-04 -1.300731e-04 -1.361905e-04
## ASV0396     -1.668481e-38 -9.685642e-05 -1.013878e-04 -1.057003e-04
## ASV4297      3.047471e-38  1.888908e-04  1.978574e-04  2.069480e-04
## ASV2622      6.888392e-38  4.292984e-04  4.495679e-04  4.703425e-04
## ASV3512      9.672295e-39  6.431918e-05  6.749330e-05  7.082858e-05
## ASV2411      2.270339e-38  1.458454e-04  1.527326e-04  1.600178e-04
## ASV2291     -5.441058e-39 -3.634073e-05 -3.822118e-05 -4.012007e-05
## ASV0807      2.604318e-38  1.700233e-04  1.781555e-04  1.867934e-04
## ASV1292      1.555548e-38  9.696567e-05  1.014606e-04  1.061476e-04
## ASV1035      7.560947e-39  4.585392e-05  4.797656e-05  5.012693e-05
## ASV0070     -1.712350e-38 -1.031557e-04 -1.079777e-04 -1.127778e-04
## ASV0255      6.544534e-39  4.138806e-05  4.329341e-05  4.532257e-05
## ASV0057     -7.196267e-38 -4.446108e-04 -4.654916e-04 -4.867951e-04
## ASV0077     -1.116893e-38 -6.605823e-05 -6.911808e-05 -7.212400e-05
## ASV0625      7.103019e-38  4.415884e-04  4.622903e-04  4.835905e-04
## ASV2464      3.477612e-38  2.144505e-04  2.244963e-04  2.347495e-04
## ASV1315      5.946957e-38  3.802862e-04  3.984103e-04  4.173309e-04
## ASV2673      4.308417e-38  2.764213e-04  2.896267e-04  3.034299e-04
## ASV2161      1.768595e-38  1.137333e-04  1.192001e-04  1.248952e-04
## ASV0337     -2.931708e-38 -1.839480e-04 -1.926992e-04 -2.016693e-04
## ASV7680     -3.404884e-38 -2.156237e-04 -2.257378e-04 -2.363461e-04
## ASV0611      7.352171e-38  4.679239e-04  4.901727e-04  5.133384e-04
## ASV3118     -2.500910e-38 -1.591103e-04 -1.665891e-04 -1.744559e-04
## ASV1284      2.644200e-38  1.681236e-04  1.759321e-04  1.842321e-04
## ASV0889      2.055484e-38  1.286152e-04  1.347390e-04  1.409945e-04
## ASV4649     -2.121874e-38 -1.340179e-04 -1.402709e-04 -1.468430e-04
## ASV1108     -2.641951e-38 -1.701282e-04 -1.781678e-04 -1.866879e-04
## ASV0738     -5.908183e-39 -2.913528e-05 -3.040752e-05 -3.140844e-05
## ASV0473      4.155210e-39  2.637619e-05  2.758255e-05  2.888163e-05
## ASV0598     -3.187637e-38 -1.962227e-04 -2.054400e-04 -2.148055e-04
## ASV0429      4.956004e-38  3.109777e-04  3.256632e-04  3.408215e-04
## ASV1549      4.785423e-38  3.077117e-04  3.223763e-04  3.377736e-04
## ASV1203      3.731441e-38  2.348373e-04  2.458620e-04  2.573400e-04
## ASV4532      1.922455e-39  1.077601e-05  1.131747e-05  1.178053e-05
## ASV0274     -3.852814e-38 -2.375162e-04 -2.487210e-04 -2.600797e-04
## ASV0163     -5.515623e-38 -3.395897e-04 -3.554121e-04 -3.716132e-04
## ASV1298      2.242946e-38  1.380283e-04  1.444312e-04  1.510109e-04
## ASV9424     -4.497007e-38 -2.856022e-04 -2.990345e-04 -3.131298e-04
## ASV0412      7.043598e-38  4.419742e-04  4.628691e-04  4.844162e-04
## ASV0284      3.217293e-38  1.989094e-04  2.082146e-04  2.177505e-04
## ASV0620     -2.264305e-38 -1.461548e-04 -1.530494e-04 -1.603837e-04
## ASV0153     -4.777492e-38 -3.050758e-04 -3.196853e-04 -3.348481e-04
## ASV0498      3.908578e-39  3.104521e-05  3.256239e-05  3.441522e-05
## ASV0097      3.406348e-38  2.183378e-04  2.286869e-04  2.395726e-04
## ASV0104     -1.612636e-37 -1.015251e-03 -1.063410e-03 -1.113091e-03
## ASV1282      2.775381e-38  1.761377e-04  1.845146e-04  1.932083e-04
## ASV3883     -1.582262e-38 -1.017875e-04 -1.065799e-04 -1.116688e-04
## ASV0801      1.543506e-38  1.008100e-04  1.055154e-04  1.106291e-04
## ASV1611     -6.138811e-38 -3.898069e-04 -4.081777e-04 -4.274152e-04
## ASV0227     -2.145864e-38 -1.399322e-04 -1.466647e-04 -1.537698e-04
## ASV0833      2.307460e-38  1.504069e-04  1.576088e-04  1.652392e-04
## ASV0718      5.752412e-38  3.635343e-04  3.807210e-04  3.985770e-04
## ASV1139      2.218115e-38  1.352790e-04  1.414905e-04  1.478665e-04
## ASV0766     -1.602961e-38 -9.989027e-05 -1.045224e-04 -1.093487e-04
## ASV2091      7.916680e-38  4.913986e-04  5.145123e-04  5.381831e-04
## ASV1238     -5.836449e-39 -3.262295e-05 -3.405784e-05 -3.543188e-05
## ASV9193     -6.133051e-39 -4.252298e-05 -4.445694e-05 -4.673151e-05
## ASV0290     -5.878822e-39 -3.974421e-05 -4.163142e-05 -4.371537e-05
## ASV0231      6.145335e-38  3.864840e-04  4.046711e-04  4.235506e-04
## ASV0185      8.140561e-39  6.379226e-05  6.699821e-05  7.078330e-05
## ASV2330      1.801334e-38  1.120670e-04  1.173681e-04  1.227824e-04
## ASV3119     -1.890145e-38 -1.245076e-04 -1.304627e-04 -1.368433e-04
## ASV2368     -2.727240e-38 -1.748282e-04 -1.830360e-04 -1.917466e-04
## ASV0122     -2.266189e-38 -1.398877e-04 -1.465446e-04 -1.532500e-04
## ASV1044      3.693122e-38  2.389199e-04  2.503432e-04  2.623734e-04
## ASV0160     -5.622767e-38 -3.459375e-04 -3.621116e-04 -3.786072e-04
## ASV0326      3.500982e-38  2.212507e-04  2.318446e-04  2.427231e-04
## ASV1388      6.164818e-38  3.883747e-04  4.067474e-04  4.257631e-04
## ASV0792      7.055394e-38  4.415925e-04  4.623180e-04  4.837740e-04
## ASV0036     -4.341619e-38 -2.764743e-04 -2.896994e-04 -3.034000e-04
## ASV2125      7.212501e-38  4.541658e-04  4.756585e-04  4.978841e-04
## ASV1075      1.338293e-38  8.595036e-05  9.009366e-05  9.439341e-05
## ASV0390      1.253755e-38  8.323216e-05  8.720603e-05  9.150437e-05
## ASV3790     -5.735622e-38 -3.638395e-04 -3.809898e-04 -3.989265e-04
## ASV1535     -4.340024e-39 -2.906227e-05 -3.044012e-05 -3.195157e-05
## ASV0263      1.187358e-38  7.523985e-05  7.873767e-05  8.243793e-05
## ASV0675      9.307161e-38  5.953542e-04  6.235828e-04  6.532020e-04
## ASV3348      8.656278e-39  5.649751e-05  5.929639e-05  6.217573e-05
## ASV0058     -9.122278e-38 -5.733053e-04 -6.003888e-04 -6.283830e-04
## ASV4142      2.292079e-38  1.439480e-04  1.506681e-04  1.576860e-04
## ASV0059     -7.879787e-38 -4.946907e-04 -5.180093e-04 -5.421330e-04
## ASV0013     -1.637259e-37 -1.030717e-03 -1.079483e-03 -1.129910e-03
## ASV0033     -4.719255e-38 -3.009042e-04 -3.152543e-04 -3.301818e-04
## ASV4354     -2.135964e-38 -1.327488e-04 -1.389715e-04 -1.453732e-04
## ASV0022     -4.986826e-38 -3.176629e-04 -3.327774e-04 -3.485173e-04
## ASV0134     -1.193838e-38 -7.800848e-05 -8.175257e-05 -8.572053e-05
## ASV0415     -1.175890e-38 -6.899319e-05 -7.215382e-05 -7.526393e-05
## ASV10103    -3.511087e-38 -2.228455e-04 -2.333023e-04 -2.442897e-04
## ASV1613      5.799264e-38  3.627341e-04  3.798057e-04  3.974225e-04
## ASV0135     -4.478038e-39 -2.207609e-05 -2.297371e-05 -2.372547e-05
## ASV0469     -7.254312e-38 -4.529830e-04 -4.741998e-04 -4.961543e-04
## ASV0471      4.519901e-38  2.860064e-04  2.994780e-04  3.135410e-04
## ASV0451     -1.173322e-38 -7.689959e-05 -8.063889e-05 -8.456663e-05
## ASV0747      1.684687e-38  1.097657e-04  1.150097e-04  1.205752e-04
## ASV1314     -2.604417e-38 -1.685798e-04 -1.765718e-04 -1.850607e-04
## ASV0425     -8.316441e-38 -5.158172e-04 -5.399914e-04 -5.648101e-04
## ASV0559     -4.740023e-38 -2.936073e-04 -3.073460e-04 -3.214553e-04
## ASV0148     -5.151179e-38 -3.186501e-04 -3.335676e-04 -3.488541e-04
## ASV0129     -2.643876e-38 -1.599418e-04 -1.673529e-04 -1.748304e-04
## ASV1072      2.514587e-38  1.549747e-04  1.622166e-04  1.696185e-04
## ASV2390      1.792174e-38  1.104756e-04  1.156676e-04  1.209480e-04
## ASV0548      5.195657e-38  3.291812e-04  3.448164e-04  3.610350e-04
## ASV0168     -7.970435e-38 -4.988831e-04 -5.223144e-04 -5.465616e-04
## ASV0066     -5.880654e-38 -3.692637e-04 -3.867069e-04 -4.047213e-04
## ASV0468     -2.156339e-38 -1.361408e-04 -1.425096e-04 -1.491839e-04
## ASV0172     -1.376210e-38 -8.026169e-05 -8.388343e-05 -8.746845e-05
## ASV0236     -3.246804e-38 -1.957487e-04 -2.047188e-04 -2.138274e-04
## ASV0250     -7.781599e-40  5.173778e-06  5.681021e-06  6.474908e-06
## ASV0338     -5.609719e-39 -2.967709e-05 -3.090303e-05 -3.205325e-05
## ASV0450     -2.980329e-40 -1.780622e-06 -1.865055e-06 -1.948045e-06
## ASV0377      6.423902e-38  4.049411e-04  4.240437e-04  4.438766e-04
## ASV1022      1.776651e-38  1.125333e-04  1.177974e-04  1.233338e-04
## ASV6174     -4.557312e-39 -2.811043e-05 -2.942073e-05 -3.076428e-05
## ASV0786      7.561788e-39  4.605753e-05  4.818542e-05  5.035450e-05
## ASV0053     -7.710100e-38 -4.867948e-04 -5.098092e-04 -5.336966e-04
## ASV0697     -2.322761e-38 -1.427703e-04 -1.494076e-04 -1.562068e-04
## ASV0785      5.747145e-38  3.625508e-04  3.796848e-04  3.974594e-04
## ASV1967     -3.902972e-38 -2.415227e-04 -2.528982e-04 -2.644943e-04
## ASV0385     -1.854378e-38 -1.134814e-04 -1.187573e-04 -1.241358e-04
## ASV0295     -1.077806e-39 -1.469306e-06 -1.402259e-06 -1.188005e-06
## ASV0072     -6.300848e-38 -3.915530e-04 -4.098479e-04 -4.287222e-04
## ASV0157     -2.674913e-38 -1.637486e-04 -1.713463e-04 -1.791038e-04
## ASV0501      2.719653e-38  1.754011e-04  1.838047e-04  1.926087e-04
## ASV10729    -4.667636e-38 -2.960433e-04 -3.100024e-04 -3.245937e-04
## ASV1470      2.276183e-38  1.418906e-04  1.485360e-04  1.554002e-04
## ASV0050     -1.552864e-37 -9.747961e-04 -1.020649e-03 -1.068174e-03
## ASV0411     -4.571970e-39 -2.634635e-05 -2.751020e-05 -2.866814e-05
## ASV0549      2.846724e-38  1.829132e-04  1.916821e-04  2.008329e-04
## ASV0184      1.803143e-38  1.135917e-04  1.189241e-04  1.244826e-04
## ASV0705      2.127130e-38  1.359615e-04  1.424307e-04  1.491878e-04
## ASV1715      5.451392e-38  3.447821e-04  3.610404e-04  3.779871e-04
## ASV0603      6.303247e-39  4.065942e-05  4.255306e-05  4.459119e-05
## ASV0826      1.883618e-38  1.166425e-04  1.220997e-04  1.277014e-04
## ASV0034     -7.066366e-38 -4.416015e-04 -4.622437e-04 -4.836592e-04
## ASV0838      1.483163e-38  9.304737e-05  9.737047e-05  1.018965e-04
## ASV0614     -4.004712e-38 -2.506635e-04 -2.624696e-04 -2.746524e-04
## ASV0014     -1.504048e-37 -9.447436e-04 -9.891238e-04 -1.035210e-03
## ASV0585     -9.271648e-39 -5.901835e-05 -6.182489e-05 -6.474717e-05
## ASV0016     -1.536910e-37 -9.657417e-04 -1.011042e-03 -1.058165e-03
## ASV5394     -3.851025e-38 -2.439616e-04 -2.554807e-04 -2.674915e-04
## ASV0666      3.316568e-38  2.083025e-04  2.180500e-04  2.282063e-04
## ASV2085      1.443304e-38  8.472616e-05  8.851199e-05  9.232563e-05
## ASV0003     -1.408628e-37 -8.839529e-04 -9.253132e-04 -9.683751e-04
## ASV0346     -4.125123e-39 -1.965175e-05 -2.032965e-05 -2.094696e-05
## ASV0267     -2.302057e-38 -1.414695e-04 -1.479090e-04 -1.546300e-04
## ASV0353      2.834266e-38  1.851254e-04  1.940515e-04  2.034665e-04
## ASV2419      3.995432e-38  2.499379e-04  2.616255e-04  2.737615e-04
## ASV0447      1.710637e-38  1.149651e-04  1.206105e-04  1.266249e-04
## ASV0654      6.042853e-38  3.841134e-04  4.023278e-04  4.213112e-04
## ASV0151      8.512835e-39  5.792983e-05  6.087544e-05  6.395209e-05
## ASV0065     -5.669201e-38 -3.564492e-04 -3.731966e-04 -3.906030e-04
## ASV0527      4.097663e-38  2.578767e-04  2.699771e-04  2.825806e-04
## ASV4055     -1.480477e-38 -9.542381e-05 -9.998134e-05 -1.047687e-04
## ASV0166     -4.804275e-38 -2.985681e-04 -3.124643e-04 -3.268542e-04
## ASV0417     -4.017932e-38 -2.514273e-04 -2.631844e-04 -2.753971e-04
## ASV0078     -3.257390e-38 -2.023835e-04 -2.117827e-04 -2.215305e-04
## ASV0322     -3.965370e-38 -2.462901e-04 -2.577269e-04 -2.695842e-04
## ASV0156     -5.105976e-38 -3.188846e-04 -3.337816e-04 -3.492372e-04
## ASV0648     -4.488601e-38 -2.856173e-04 -2.991022e-04 -3.132289e-04
## ASV0407      3.103441e-39  2.132364e-05  2.238323e-05  2.352379e-05
## ASV2030     -1.031307e-38 -6.227141e-05 -6.520200e-05 -6.811218e-05
## ASV0300      2.546967e-38  1.657125e-04  1.737194e-04  1.821155e-04
## ASV1150     -3.852651e-39 -2.253464e-05 -2.350581e-05 -2.451053e-05
## ASV0958      2.664002e-38  1.731340e-04  1.814351e-04  1.901962e-04
## ASV0216     -4.906846e-38 -3.042568e-04 -3.183550e-04 -3.329800e-04
## ASV0446      6.489840e-38  4.167652e-04  4.365853e-04  4.574037e-04
## ASV0367     -2.295717e-38 -1.442267e-04 -1.509853e-04 -1.580216e-04
## ASV0200     -4.250453e-38 -2.682050e-04 -2.808313e-04 -2.939820e-04
## ASV0334     -2.377183e-38 -1.421075e-04 -1.484606e-04 -1.549958e-04
## ASV1311      3.031849e-38  1.899069e-04  1.987567e-04  2.079851e-04
## ASV0458      3.264472e-38  2.048211e-04  2.145000e-04  2.244843e-04
## ASV1371      9.212320e-40  6.080254e-06  6.383125e-06  6.696727e-06
## ASV0418      3.956423e-38  2.496553e-04  2.613748e-04  2.736124e-04
## ASV0004      4.709975e-38  2.966069e-04  3.105735e-04  3.250851e-04
## ASV1943      3.491045e-38  2.175046e-04  2.278045e-04  2.383315e-04
## ASV1495     -7.505106e-39 -5.143902e-05 -5.403604e-05 -5.678355e-05
## ASV0901     -5.270082e-38 -3.360551e-04 -3.520114e-04 -3.686804e-04
## ASV0628      3.182044e-38  1.984165e-04  2.076485e-04  2.172433e-04
## ASV0400      1.272268e-38  7.945046e-05  8.314678e-05  8.699379e-05
## ASV0116     -4.015755e-38 -2.580865e-04 -2.703479e-04 -2.832524e-04
## ASV0788      3.388298e-38  2.141518e-04  2.242566e-04  2.347750e-04
## ASV0117      2.104939e-38  1.364240e-04  1.429793e-04  1.498636e-04
## ASV3137      6.088051e-39  3.791623e-05  3.970462e-05  4.153870e-05
## ASV0001      5.769339e-38  3.581413e-04  3.747907e-04  3.920276e-04
## ASV1651      3.849282e-38  2.388997e-04  2.499745e-04  2.614694e-04
## ASV1692      3.916604e-38  2.514605e-04  2.634517e-04  2.760142e-04
## ASV0660      2.398237e-38  1.471638e-04  1.539037e-04  1.608848e-04
## ASV0508      3.230712e-39  1.855175e-05  1.940453e-05  2.022018e-05
## ASV1660     -1.583265e-38 -1.028230e-04 -1.077683e-04 -1.129659e-04
## ASV0233      8.806217e-39  5.716965e-05  5.993671e-05  6.282900e-05
## ASV1343     -4.010104e-38 -2.543838e-04 -2.664080e-04 -2.789523e-04
## ASV0209      3.847575e-38  2.380252e-04  2.490540e-04  2.604645e-04
## ASV0193     -4.956363e-38 -3.088622e-04 -3.231897e-04 -3.381152e-04
## ASV0357     -3.708285e-39 -1.953724e-05 -2.031624e-05 -2.106165e-05
## ASV0198      1.029473e-38  6.548113e-05  6.857812e-05  7.181555e-05
## ASV0007      5.469502e-38  3.395376e-04  3.552959e-04  3.716357e-04
## ASV1772     -5.550091e-39 -3.467380e-05 -3.628623e-05 -3.796546e-05
## ASV0009      5.167512e-38  3.204613e-04  3.352972e-04  3.506988e-04
## ASV0006      2.157679e-38  1.303076e-04  1.361999e-04  1.422692e-04
## ASV0011     -5.581552e-38 -3.551291e-04 -3.719002e-04 -3.894659e-04
## ASV0015      3.953436e-38  2.492478e-04  2.609675e-04  2.731742e-04
## ASV0017      4.193162e-38  2.640661e-04  2.764409e-04  2.893550e-04
## ASV0235     -3.262141e-38 -2.074319e-04 -2.172357e-04 -2.274877e-04
## ASV0382      4.625552e-39  3.491635e-05  3.681396e-05  3.883721e-05
## ASV2357      4.986866e-38  3.158868e-04  3.307678e-04  3.463181e-04
## ASV0567     -3.682815e-38 -2.304282e-04 -2.411708e-04 -2.523603e-04
## ASV0165      3.988685e-38  2.514291e-04  2.632803e-04  2.755937e-04
## ASV0005      8.107507e-38  5.079132e-04  5.316402e-04  5.563351e-04
## ASV0384     -4.532717e-39 -2.527178e-05 -2.630848e-05 -2.736124e-05
## ASV0002      1.659396e-38  1.073716e-04  1.125290e-04  1.179397e-04
## ASV3017      4.757079e-38  2.967472e-04  3.105016e-04  3.248571e-04
## ASV0091      1.764900e-38  1.129276e-04  1.182856e-04  1.239049e-04
## ASV0186     -4.797272e-38 -3.041679e-04 -3.184877e-04 -3.334730e-04
## ASV0370      4.710406e-39  3.070008e-05  3.211996e-05  3.367391e-05
## ASV0018      8.430121e-38  5.288148e-04  5.535112e-04  5.792574e-04
## ASV1377      7.378245e-38  4.620171e-04  4.835690e-04  5.060201e-04
## ASV0019      8.439473e-38  5.295109e-04  5.542003e-04  5.799824e-04
## ASV0023      7.066716e-39  3.891951e-05  4.045232e-05  4.204504e-05
## ASV2194      2.682544e-38  1.713287e-04  1.794679e-04  1.879808e-04
## ASV1155     -3.632665e-39 -2.061259e-05 -2.129396e-05 -2.216199e-05
## ASV0510     -3.222010e-38 -1.967476e-04 -2.055820e-04 -2.148570e-04
## ASV2371     -3.120574e-38 -1.919784e-04 -2.009976e-04 -2.101552e-04
## ASV0024      3.056467e-39  1.358095e-05  1.392148e-05  1.427024e-05
## ASV2452      4.023230e-38  2.499164e-04  2.613939e-04  2.734175e-04
## ASV2332      7.898870e-40  1.088705e-05  1.142742e-05  1.226554e-05
## ASV2591      5.921995e-40  9.715932e-06  1.019489e-05  1.097755e-05
## ASV0521      5.271635e-38  3.371330e-04  3.531457e-04  3.699168e-04
## ASV5542      1.600784e-38  1.041186e-04  1.089563e-04  1.142131e-04
## ASV0336     -2.531440e-38 -1.592142e-04 -1.666450e-04 -1.744180e-04
## ASV10102     3.682342e-38  2.344899e-04  2.455203e-04  2.571235e-04
## ASV16823    -3.040027e-38 -1.861720e-04 -1.949377e-04 -2.037772e-04
## ASV3104      3.040027e-38  1.861720e-04  1.949228e-04  2.037615e-04
## ASV0781      1.428856e-38  8.952774e-05  9.365208e-05  9.800044e-05
## ASV10899     1.253085e-38  8.442242e-05  8.848875e-05  9.290881e-05
## ASV11222    -3.040027e-38 -1.861720e-04 -1.949126e-04 -2.037509e-04
## ASV11327    -3.040027e-38 -1.861720e-04 -1.948978e-04 -2.037352e-04
## ASV12458    -3.040027e-38 -1.861720e-04 -1.948831e-04 -2.037196e-04
## ASV1636     -2.490636e-38 -1.524142e-04 -1.594418e-04 -1.666603e-04
## ASV1890     -3.007323e-38 -1.851962e-04 -1.938751e-04 -2.027216e-04
## ASV2898      6.377943e-38  3.991102e-04  4.176855e-04  4.370608e-04
## ASV8328     -6.226076e-39 -3.269425e-05 -3.410095e-05 -3.535726e-05
## ASV0709     -5.198536e-38 -3.261487e-04 -3.412910e-04 -3.571631e-04
## ASV0856      7.771543e-39  5.134275e-05  5.380153e-05  5.643950e-05
## ASV0909     -2.335561e-38 -1.399265e-04 -1.461287e-04 -1.525751e-04
## ASV0937     -4.008191e-38 -2.535362e-04 -2.655637e-04 -2.780369e-04
## ASV11390    -3.040027e-38 -1.861720e-04 -1.948512e-04 -2.036860e-04
## ASV11966     1.420327e-38  9.340981e-05  9.786684e-05  1.026432e-04
## ASV12990     7.819545e-39  5.019317e-05  5.247509e-05  5.496986e-05
## ASV14797     3.089629e-38  1.921482e-04  2.009666e-04  2.102222e-04
## ASV14904    -3.040027e-38 -1.861719e-04 -1.948465e-04 -2.036815e-04
## ASV15304     7.030854e-39  4.886138e-05  5.123167e-05  5.386000e-05
## ASV16696    -3.040027e-38 -1.861719e-04 -1.948342e-04 -2.036685e-04
## ASV1690      1.419706e-38  9.467613e-05  9.925009e-05  1.041570e-04
## ASV2029      8.151639e-38  5.118374e-04  5.357077e-04  5.606507e-04
## ASV2834      4.329441e-38  2.736525e-04  2.865398e-04  2.999809e-04
## ASV4003      1.121142e-38  7.697335e-05  8.073674e-05  8.483879e-05
## ASV4064      2.989265e-38  1.910120e-04  2.000037e-04  2.094872e-04
## ASV4294      9.589711e-39  6.514727e-05  6.832823e-05  7.176777e-05
## ASV4609     -1.530065e-39 -7.910627e-06 -8.343396e-06 -8.649839e-06
## ASV6283     -3.040027e-38 -1.861719e-04 -1.948309e-04 -2.036660e-04
## ASV6491     -3.040027e-38 -1.861719e-04 -1.948162e-04 -2.036503e-04
## ASV7453      1.059821e-38  7.189984e-05  7.540223e-05  7.919080e-05
## ASV7959      1.319226e-39  1.336932e-05  1.409242e-05  1.500950e-05
## ASV8219      3.040027e-38  1.861719e-04  1.948055e-04  2.036392e-04
## ASV8547     -3.040027e-38 -1.861719e-04 -1.947909e-04 -2.036235e-04
## ASV9319      1.938115e-38  1.245389e-04  1.303951e-04  1.366117e-04
## ASV9382     -3.040027e-38 -1.861719e-04 -1.947817e-04 -2.036139e-04
## ASV11516    -3.040027e-38 -1.861719e-04 -1.947672e-04 -2.035982e-04
## ASV14377    -3.040027e-38 -1.861718e-04 -1.947526e-04 -2.035826e-04
## ASV1867      4.243133e-38  2.701572e-04  2.829021e-04  2.962702e-04
## ASV1895     -1.045979e-38 -6.363248e-05 -6.651828e-05 -6.951037e-05
## ASV3168      1.850837e-38  1.157551e-04  1.210767e-04  1.266811e-04
## ASV4449      3.739630e-38  2.312766e-04  2.420048e-04  2.530975e-04
## ASV6596      1.994017e-38  1.309193e-04  1.372577e-04  1.439510e-04
## ASV7492     -1.214220e-38 -7.039246e-05 -7.348614e-05 -7.660670e-05
## ASV9854     -1.586802e-38 -9.606590e-05 -1.004721e-04 -1.049717e-04
## ASV6296      3.040027e-38  1.861718e-04  1.947215e-04  2.035493e-04
## ASV4201      8.213575e-39  5.894788e-05  6.198852e-05  6.526038e-05
## ASV0552      7.091608e-38  4.518652e-04  4.732535e-04  4.956394e-04
## ASV3671     -6.933592e-39 -3.907356e-05 -4.075715e-05 -4.242789e-05
## ASV3529     -7.618069e-39 -4.199743e-05 -4.374597e-05 -4.548362e-05
## ASV1060      1.780419e-38  1.137074e-04  1.191108e-04  1.247612e-04
## ASV0239     -4.212994e-38 -2.596357e-04 -2.715326e-04 -2.839156e-04
## ASV5711     -3.858562e-38 -2.385560e-04 -2.495755e-04 -2.610094e-04
## ASV4152     -5.028716e-38 -3.143754e-04 -3.290136e-04 -3.442676e-04
## ASV1461      4.545945e-38  2.811716e-04  2.940592e-04  3.075208e-04
## ASV2877      3.640261e-38  2.284034e-04  2.390359e-04  2.501520e-04
## ASV0012      2.642182e-38  1.700981e-04  1.782530e-04  1.867778e-04
## ASV9823      1.022522e-38  6.248668e-05  6.530946e-05  6.825689e-05
## ASV0008      2.903262e-38  1.860927e-04  1.949598e-04  2.042410e-04
## ASV7832     -3.117744e-38 -1.937631e-04 -2.027474e-04 -2.120905e-04
## ASV1915      1.884721e-39  1.454413e-05  1.534223e-05  1.619559e-05
## ASV0055      2.110467e-38  1.329004e-04  1.391241e-04  1.456215e-04
## ASV0032      5.174495e-38  3.225017e-04  3.374179e-04  3.530011e-04
## ASV2977     -4.236458e-38 -2.647857e-04 -2.770912e-04 -2.899336e-04
## ASV0466      4.341784e-38  2.690150e-04  2.813895e-04  2.943019e-04
## ASV3866      4.428837e-38  2.813753e-04  2.946381e-04  3.085304e-04
## ASV0040      5.852469e-38  3.735919e-04  3.912923e-04  4.098373e-04
## ASV0496     -2.206917e-39 -1.873837e-05 -1.984616e-05 -2.103045e-05
## ASV0052      7.282631e-38  4.571700e-04  4.784699e-04  5.007403e-04
## ASV3828     -4.522951e-38 -2.820159e-04 -2.950936e-04 -3.087377e-04
## ASV1930      2.768340e-38  1.751902e-04  1.834249e-04  1.920330e-04
## ASV2126      4.533398e-38  2.853177e-04  2.986402e-04  3.125770e-04
## ASV0793      2.607435e-38  1.697940e-04  1.779984e-04  1.866093e-04
## ASV0299     -2.003054e-38 -1.210647e-04 -1.264887e-04 -1.321315e-04
## ASV0208      4.123216e-38  2.644850e-04  2.770884e-04  2.902896e-04
## ASV0511     -2.426196e-38 -1.467718e-04 -1.533269e-04 -1.601653e-04
## ASV1123     -3.131395e-38 -1.924025e-04 -2.011599e-04 -2.103017e-04
## ASV0099     -1.685390e-38 -1.052357e-04 -1.101063e-04 -1.151962e-04
## ASV0752     -2.883957e-39 -2.084376e-05 -2.192580e-05 -2.308699e-05
## ASV0883      1.221272e-40  2.373312e-06  2.532193e-06  2.732560e-06
## ASV0683      3.687287e-38  2.363366e-04  2.475854e-04  2.593685e-04
## ASV4117     -4.545179e-38 -2.837620e-04 -2.969357e-04 -3.106835e-04
## ASV2172      1.665364e-38  1.055248e-04  1.104844e-04  1.156773e-04
## ASV0330     -3.022947e-38 -1.916115e-04 -2.006303e-04 -2.100661e-04
## ASV0728      2.813973e-38  1.811200e-04  1.897547e-04  1.988196e-04
## ASV0499      5.569071e-38  3.566883e-04  3.736585e-04  3.914333e-04
## ASV0120     -6.313502e-38 -3.982444e-04 -4.168781e-04 -4.363797e-04
## ASV1446      6.044190e-39  3.420902e-05  3.564605e-05  3.710991e-05
## ASV17171    -4.305784e-38 -2.693553e-04 -2.818830e-04 -2.949625e-04
## ASV0533      1.169723e-38  7.554038e-05  7.917291e-05  8.297234e-05
## ASV2495     -1.703725e-38 -1.084418e-04 -1.135888e-04 -1.189638e-04
## ASV5582      1.573573e-38  9.603150e-05  1.003560e-04  1.048786e-04
## ASV1488      1.333731e-38  8.589538e-05  8.998741e-05  9.429015e-05
## ASV0682      3.878487e-38  2.483595e-04  2.601720e-04  2.725448e-04
## ASV0068     -1.569197e-39 -1.374209e-05 -1.457184e-05 -1.545627e-05
## ASV1987     -2.040273e-38 -1.336318e-04 -1.401111e-04 -1.469259e-04
## ASV0035      8.741778e-39  4.918705e-05  5.119209e-05  5.326604e-05
## ASV7192     -2.954758e-38 -1.823057e-04 -1.906704e-04 -1.993818e-04
## ASV0873      4.983130e-39  2.780399e-05  2.894903e-05  3.011754e-05
## ASV4749      3.649700e-39  1.719777e-05  1.771264e-05  1.823025e-05
## ASV2174      2.827707e-38  1.736411e-04  1.815371e-04  1.897828e-04
## ASV1476     -2.364743e-38 -1.492825e-04 -1.562933e-04 -1.636200e-04
## ASV0740     -5.655336e-38 -3.616112e-04 -3.787892e-04 -3.967741e-04
## ASV0170      1.225668e-38  7.729607e-05  8.091972e-05  8.470699e-05
## ASV2466     -5.252633e-38 -3.304365e-04 -3.458715e-04 -3.620162e-04
## ASV1709      4.103967e-38  2.569605e-04  2.688981e-04  2.813834e-04
## ASV6170     -3.701779e-38 -2.350778e-04 -2.461756e-04 -2.577794e-04
## ASV3673      4.233390e-38  2.690304e-04  2.817258e-04  2.950150e-04
## ASV1745      3.214905e-39  2.060700e-05  2.158734e-05  2.261402e-05
##                                                                    
## (Intercept) -1.556703e-06 -1.781471e-06 -2.038243e-06 -2.331488e-06
## ASV1236      2.231565e-04  2.334100e-04  2.441169e-04  2.552955e-04
## ASV0421     -3.964882e-04 -4.147721e-04 -4.338709e-04 -4.538181e-04
## ASV0691     -3.467557e-04 -3.624944e-04 -3.789110e-04 -3.960311e-04
## ASV0899     -5.935691e-06 -6.042248e-06 -6.138159e-06 -6.221562e-06
## ASV1004      4.505582e-04  4.713488e-04  4.930670e-04  5.157512e-04
## ASV1041     -3.049122e-04 -3.189948e-04 -3.337065e-04 -3.490736e-04
## ASV1058      4.187994e-04  4.381261e-04  4.583154e-04  4.794031e-04
## ASV12542     1.293031e-04  1.351510e-04  1.412488e-04  1.476057e-04
## ASV1294      4.862748e-04  5.088336e-04  5.324104e-04  5.570484e-04
## ASV13113     1.734694e-04  1.817367e-04  1.903984e-04  1.994733e-04
## ASV1318      4.244488e-04  4.440516e-04  4.645305e-04  4.859221e-04
## ASV2269     -1.263726e-04 -1.322204e-04 -1.383303e-04 -1.447135e-04
## ASV2542      2.713136e-04  2.841510e-04  2.975915e-04  3.116634e-04
## ASV2660     -2.451707e-04 -2.564158e-04 -2.681559e-04 -2.804110e-04
## ASV2737     -1.227316e-05 -1.292700e-05 -1.361799e-05 -1.434843e-05
## ASV2840      3.265870e-04  3.415159e-04  3.570973e-04  3.733570e-04
## ASV3053      1.786297e-05  1.865083e-05  1.947070e-05  2.032356e-05
## ASV3077      1.016217e-04  1.062794e-04  1.111421e-04  1.162181e-04
## ASV3134      3.496556e-04  3.662702e-04  3.836727e-04  4.019002e-04
## ASV3140      1.537175e-04  1.609805e-04  1.685834e-04  1.765420e-04
## ASV3579      6.109375e-05  6.413503e-05  6.733362e-05  7.069812e-05
## ASV6119     -1.263523e-04 -1.321982e-04 -1.383060e-04 -1.446869e-04
## ASV7557     -1.263419e-04 -1.321868e-04 -1.382936e-04 -1.446733e-04
## ASV8422      7.061596e-05  7.380939e-05  7.713947e-05  8.061132e-05
## ASV1086     -3.549559e-05 -3.709522e-05 -3.876286e-05 -4.050101e-05
## ASV1310      2.405268e-04  2.516996e-04  2.633778e-04  2.755831e-04
## ASV15750    -5.998006e-05 -6.273074e-05 -6.560221e-05 -6.859929e-05
## ASV16905    -1.263380e-04 -1.321825e-04 -1.382889e-04 -1.446681e-04
## ASV2033      2.367076e-04  2.479472e-04  2.597189e-04  2.720475e-04
## ASV2089      8.645299e-05  9.046447e-05  9.465675e-05  9.903750e-05
## ASV2127      3.459688e-04  3.619723e-04  3.786936e-04  3.961628e-04
## ASV2725      3.924997e-04  4.104758e-04  4.292412e-04  4.488273e-04
## ASV2804     -1.263353e-04 -1.321796e-04 -1.382857e-04 -1.446647e-04
## ASV3075      2.481224e-04  2.596549e-04  2.717104e-04  2.843116e-04
## ASV3327      2.314379e-04  2.423829e-04  2.538419e-04  2.658388e-04
## ASV3342      2.524114e-04  2.642738e-04  2.766859e-04  2.896726e-04
## ASV3532     -2.277954e-04 -2.384905e-04 -2.496803e-04 -2.613870e-04
## ASV3600      2.890015e-04  3.025377e-04  3.166973e-04  3.315081e-04
## ASV4013      2.435471e-04  2.548382e-04  2.666382e-04  2.789687e-04
## ASV4136      2.420600e-04  2.531849e-04  2.648020e-04  2.769313e-04
## ASV4195      1.263204e-04  1.321632e-04  1.382678e-04  1.446451e-04
## ASV4407     -1.263100e-04 -1.321518e-04 -1.382554e-04 -1.446315e-04
## ASV4717      7.529025e-06  7.796893e-06  8.069483e-06  8.346316e-06
## ASV6794      1.312070e-04  1.371515e-04  1.433511e-04  1.498157e-04
## ASV8324     -1.263073e-04 -1.321489e-04 -1.382521e-04 -1.446279e-04
## ASV8981     -3.436784e-05 -3.585404e-05 -3.739667e-05 -3.899713e-05
## ASV9859      9.590249e-05  1.005756e-04  1.054815e-04  1.106321e-04
## ASV0936     -1.983858e-04 -2.075779e-04 -2.171840e-04 -2.272215e-04
## ASV12683    -2.003034e-05 -2.102254e-05 -2.206518e-05 -2.316093e-05
## ASV1293      2.931556e-04  3.066669e-04  3.207795e-04  3.355181e-04
## ASV13055    -3.096385e-05 -3.236060e-05 -3.381631e-05 -3.533312e-05
## ASV17063    -1.262891e-04 -1.321290e-04 -1.382304e-04 -1.446042e-04
## ASV2228      1.262787e-04  1.321176e-04  1.382179e-04  1.445906e-04
## ASV2769     -2.378542e-05 -2.478686e-05 -2.582364e-05 -2.689631e-05
## ASV2803      6.066531e-05  6.339077e-05  6.623112e-05  6.919051e-05
## ASV2896      1.585248e-04  1.659502e-04  1.737180e-04  1.818436e-04
## ASV3062      4.781807e-05  5.020336e-05  5.271247e-05  5.535223e-05
## ASV3107      1.909127e-04  1.998608e-04  2.092217e-04  2.190139e-04
## ASV3265      3.813362e-04  3.988979e-04  4.172400e-04  4.363942e-04
## ASV3666     -8.521644e-06 -8.940795e-06 -9.381031e-06 -9.843462e-06
## ASV4497      9.033682e-05  9.450181e-05  9.885249e-05  1.033965e-04
## ASV6914     -4.405642e-05 -4.613538e-05 -4.831128e-05 -5.058852e-05
## ASV0576     -4.514208e-04 -4.719872e-04 -4.934466e-04 -5.158337e-04
## ASV0673      1.157056e-04  1.212684e-04  1.271004e-04  1.332147e-04
## ASV0772      1.360837e-04  1.424165e-04  1.490372e-04  1.559584e-04
## ASV0862     -1.100718e-04 -1.150183e-04 -1.201730e-04 -1.255431e-04
## ASV0898      1.115397e-04  1.169122e-04  1.225458e-04  1.284534e-04
## ASV0910      2.417784e-04  2.533046e-04  2.653806e-04  2.780326e-04
## ASV0964     -1.633088e-04 -1.707827e-04 -1.785841e-04 -1.867263e-04
## ASV10059     1.129880e-04  1.183962e-04  1.240646e-04  1.300060e-04
## ASV10263    -1.263353e-04 -1.321796e-04 -1.382858e-04 -1.446649e-04
## ASV1088      1.283916e-04  1.345228e-04  1.409479e-04  1.476809e-04
## ASV1101      2.192957e-04  2.295051e-04  2.401784e-04  2.513355e-04
## ASV1183      1.400235e-04  1.465888e-04  1.534567e-04  1.606407e-04
## ASV11956     5.536413e-05  5.781990e-05  6.037615e-05  6.303620e-05
## ASV12774    -1.878199e-05 -1.970465e-05 -2.067362e-05 -2.169131e-05
## ASV1321      5.485100e-05  5.761448e-05  6.052367e-05  6.358677e-05
## ASV13793    -1.263233e-04 -1.321664e-04 -1.382714e-04 -1.446491e-04
## ASV14482    -1.124259e-05 -1.182703e-05 -1.244345e-05 -1.309371e-05
## ASV15483     8.876385e-05  9.294399e-05  9.731894e-05  1.018976e-04
## ASV2062      5.577737e-04  5.837511e-04  6.109105e-04  6.393033e-04
## ASV2132      2.532991e-04  2.652406e-04  2.777393e-04  2.908209e-04
## ASV2413      3.613307e-04  3.780126e-04  3.954399e-04  4.136439e-04
## ASV2490      2.382302e-04  2.491356e-04  2.605193e-04  2.724004e-04
## ASV2594      1.303707e-04  1.364448e-04  1.427961e-04  1.494367e-04
## ASV2822     -1.263404e-04 -1.321852e-04 -1.382919e-04 -1.446716e-04
## ASV2863      2.208099e-04  2.309685e-04  2.415774e-04  2.526552e-04
## ASV2910      2.880583e-04  3.012900e-04  3.151066e-04  3.295318e-04
## ASV2980      1.042723e-04  1.090751e-04  1.140911e-04  1.193290e-04
## ASV3307      1.263230e-04  1.321662e-04  1.382711e-04  1.446488e-04
## ASV3474      1.970159e-04  2.064258e-04  2.162863e-04  2.266190e-04
## ASV3502      4.118289e-04  4.310410e-04  4.511305e-04  4.721358e-04
## ASV4236      2.096033e-04  2.192006e-04  2.292192e-04  2.396758e-04
## ASV4842     -6.884220e-05 -7.205363e-05 -7.541133e-05 -7.892159e-05
## ASV4894     -1.263350e-04 -1.321793e-04 -1.382855e-04 -1.446646e-04
## ASV5290      1.555080e-04  1.627688e-04  1.703617e-04  1.783013e-04
## ASV5501      2.919666e-05  3.054916e-05  3.196280e-05  3.344024e-05
## ASV5795      1.044945e-04  1.094444e-04  1.146277e-04  1.200550e-04
## ASV5987     -1.263390e-04 -1.321837e-04 -1.382904e-04 -1.446700e-04
## ASV6267     -1.263286e-04 -1.321724e-04 -1.382780e-04 -1.446564e-04
## ASV6862      2.449988e-04  2.561462e-04  2.677764e-04  2.799080e-04
## ASV7145      4.518038e-05  4.720128e-05  4.930672e-05  5.149972e-05
## ASV7673     -1.263259e-04 -1.321694e-04 -1.382747e-04 -1.446528e-04
## ASV7789      4.518000e-05  4.745640e-05  4.985304e-05  5.237677e-05
## ASV7809     -1.603765e-05 -1.668379e-05 -1.734959e-05 -1.803496e-05
## ASV8002     -1.263179e-04 -1.321606e-04 -1.382652e-04 -1.446424e-04
## ASV8205      7.354610e-05  7.697805e-05  8.056712e-05  8.432026e-05
## ASV9155     -9.519400e-05 -9.958493e-05 -1.041714e-04 -1.089614e-04
## ASV9221     -1.493102e-05 -1.551146e-05 -1.610713e-05 -1.671759e-05
## ASV9311     -1.263038e-04 -1.321452e-04 -1.382483e-04 -1.446240e-04
## ASV9557     -1.262934e-04 -1.321338e-04 -1.382359e-04 -1.446104e-04
## ASV9936     -1.262830e-04 -1.321224e-04 -1.382234e-04 -1.445967e-04
## ASV1445      2.911568e-04  3.048540e-04  3.191878e-04  3.341868e-04
## ASV4232      2.455022e-04  2.571678e-04  2.693867e-04  2.821852e-04
## ASV6479     -1.964250e-06 -1.863622e-06 -1.740069e-06 -1.590842e-06
## ASV0142     -6.411693e-04 -6.706020e-04 -7.013336e-04 -7.334166e-04
## ASV0378     -2.106023e-04 -2.201803e-04 -2.301721e-04 -2.405936e-04
## ASV1122      3.847337e-04  4.028452e-04  4.217990e-04  4.416337e-04
## ASV0123     -6.281785e-04 -6.570011e-04 -6.870945e-04 -7.185098e-04
## ASV2064      6.551401e-05  6.843617e-05  7.147930e-05  7.464755e-05
## ASV4459     -6.936772e-05 -7.255953e-05 -7.589272e-05 -7.937301e-05
## ASV0448      1.087262e-04  1.140832e-04  1.197117e-04  1.256260e-04
## ASV0397      2.878646e-04  3.013483e-04  3.154529e-04  3.302058e-04
## ASV0485      4.035820e-04  4.223490e-04  4.419676e-04  4.624742e-04
## ASV1566      3.373641e-04  3.531500e-04  3.696611e-04  3.869294e-04
## ASV1365      2.185203e-04  2.287632e-04  2.394785e-04  2.506873e-04
## ASV1065      4.476182e-04  4.685830e-04  4.905128e-04  5.134504e-04
## ASV0722     -9.568780e-06 -9.966749e-06 -1.037857e-05 -1.080448e-05
## ASV12660    -2.113562e-04 -2.210275e-04 -2.311228e-04 -2.416591e-04
## ASV0223     -8.493031e-06 -8.867466e-06 -9.256854e-06 -9.661638e-06
## ASV0229      1.997577e-04  2.091962e-04  2.190772e-04  2.294211e-04
## ASV0877     -7.722825e-05 -8.069183e-05 -8.430038e-05 -8.805896e-05
## ASV0983      4.123167e-04  4.314278e-04  4.513998e-04  4.722691e-04
## ASV0626     -1.369228e-04 -1.429826e-04 -1.492882e-04 -1.558475e-04
## ASV4146     -2.272942e-05 -2.376308e-05 -2.484134e-05 -2.596588e-05
## ASV4175     -2.522455e-04 -2.640435e-04 -2.763828e-04 -2.892874e-04
## ASV2082     -1.769398e-05 -1.865601e-05 -1.967544e-05 -2.075610e-05
## ASV2272      1.818531e-04  1.904313e-04  1.994106e-04  2.088092e-04
## ASV2245     -2.194816e-04 -2.297877e-04 -2.405705e-04 -2.518513e-04
## ASV0590     -1.325376e-04 -1.389783e-04 -1.457377e-04 -1.528319e-04
## ASV0217     -2.070542e-04 -2.160756e-04 -2.254489e-04 -2.351837e-04
## ASV0416      2.066211e-04  2.159463e-04  2.256678e-04  2.358001e-04
## ASV1056      2.424693e-04  2.540663e-04  2.662198e-04  2.789568e-04
## ASV7777     -2.176881e-04 -2.278790e-04 -2.385386e-04 -2.496876e-04
## ASV0455      4.348231e-05  4.560211e-05  4.782704e-05  5.016241e-05
## ASV0604      4.657770e-05  4.897652e-05  5.150617e-05  5.417434e-05
## ASV6100     -2.009571e-04 -2.103815e-04 -2.202409e-04 -2.305547e-04
## ASV11359    -2.252420e-04 -2.357430e-04 -2.467227e-04 -2.582019e-04
## ASV6604      1.593389e-04  1.668838e-04  1.747839e-04  1.830558e-04
## ASV5004     -1.322115e-04 -1.383688e-04 -1.448060e-04 -1.515355e-04
## ASV1483     -1.218725e-04 -1.275686e-04 -1.335256e-04 -1.397551e-04
## ASV9773     -2.575330e-04 -2.695942e-04 -2.822106e-04 -2.954066e-04
## ASV4059      2.395981e-05  2.521153e-05  2.653323e-05  2.792919e-05
## ASV1193      4.194464e-04  4.390516e-04  4.595553e-04  4.809973e-04
## ASV4610     -3.800081e-05 -3.951634e-05 -4.107724e-05 -4.268329e-05
## ASV0742     -1.587523e-04 -1.658027e-04 -1.731415e-04 -1.807781e-04
## ASV1502     -1.861587e-06 -2.066024e-06 -2.290862e-06 -2.538018e-06
## ASV0195     -4.548109e-05 -4.776195e-05 -5.016173e-05 -5.268697e-05
## ASV1213      1.338008e-04  1.398711e-04  1.462022e-04  1.528040e-04
## ASV1648     -1.907011e-04 -1.996135e-04 -2.089343e-04 -2.186816e-04
## ASV6984     -1.425882e-04 -1.492823e-04 -1.562860e-04 -1.636133e-04
## ASV0396     -1.101776e-04 -1.148166e-04 -1.196204e-04 -1.245916e-04
## ASV4297      2.164456e-04  2.263623e-04  2.367149e-04  2.475208e-04
## ASV2622      4.920531e-04  5.147333e-04  5.384233e-04  5.631649e-04
## ASV3512      7.433613e-05  7.802347e-05  8.190034e-05  8.597704e-05
## ASV2411      1.676488e-04  1.756439e-04  1.840205e-04  1.927969e-04
## ASV2291     -4.212013e-05 -4.422396e-05 -4.643725e-05 -4.876610e-05
## ASV0807      1.958547e-04  2.053627e-04  2.153398e-04  2.258098e-04
## ASV1292      1.110450e-04  1.161609e-04  1.215045e-04  1.270852e-04
## ASV1035      5.237058e-05  5.470790e-05  5.714235e-05  5.967732e-05
## ASV0070     -1.177768e-04 -1.229791e-04 -1.283910e-04 -1.340189e-04
## ASV0255      4.744383e-05  4.966233e-05  5.198242e-05  5.440851e-05
## ASV0057     -5.090388e-04 -5.322540e-04 -5.564789e-04 -5.817529e-04
## ASV0077     -7.524824e-05 -7.849230e-05 -8.185913e-05 -8.535169e-05
## ASV0625      5.058417e-04  5.290796e-04  5.533445e-04  5.786781e-04
## ASV2464      2.454577e-04  2.566321e-04  2.682913e-04  2.804540e-04
## ASV1315      4.371482e-04  4.579037e-04  4.796415e-04  5.024076e-04
## ASV2673      3.178926e-04  3.330453e-04  3.489208e-04  3.655536e-04
## ASV2161      1.308650e-04  1.371213e-04  1.436777e-04  1.505489e-04
## ASV0337     -2.110502e-04 -2.208569e-04 -2.311077e-04 -2.418215e-04
## ASV7680     -2.474433e-04 -2.590539e-04 -2.712010e-04 -2.839085e-04
## ASV0611      5.375931e-04  5.629849e-04  5.895663e-04  6.173921e-04
## ASV3118     -1.826882e-04 -1.913052e-04 -2.003245e-04 -2.097644e-04
## ASV1284      1.929163e-04  2.020055e-04  2.115183e-04  2.214738e-04
## ASV0889      1.475364e-04  1.543739e-04  1.615195e-04  1.689866e-04
## ASV4649     -1.537155e-04 -1.609039e-04 -1.684220e-04 -1.762844e-04
## ASV1108     -1.956143e-04 -2.049690e-04 -2.147726e-04 -2.250468e-04
## ASV0738     -3.241888e-05 -3.343231e-05 -3.444475e-05 -3.545169e-05
## ASV0473      3.024132e-05  3.166433e-05  3.315366e-05  3.471236e-05
## ASV0598     -2.245807e-04 -2.347791e-04 -2.454170e-04 -2.565110e-04
## ASV0429      3.566687e-04  3.732345e-04  3.905495e-04  4.086457e-04
## ASV1549      3.539081e-04  3.708154e-04  3.885327e-04  4.070990e-04
## ASV1203      2.693421e-04  2.818918e-04  2.950130e-04  3.087305e-04
## ASV4532      1.226168e-05  1.275868e-05  1.327166e-05  1.380075e-05
## ASV0274     -2.719386e-04 -2.843132e-04 -2.972236e-04 -3.106905e-04
## ASV0163     -3.885216e-04 -4.061616e-04 -4.245615e-04 -4.437501e-04
## ASV1298      1.578782e-04  1.650423e-04  1.725148e-04  1.803075e-04
## ASV9424     -3.278808e-04 -3.433190e-04 -3.594757e-04 -3.763835e-04
## ASV0412      5.069489e-04  5.305044e-04  5.551269e-04  5.808624e-04
## ASV0284      2.277088e-04  2.381030e-04  2.489505e-04  2.602691e-04
## ASV0620     -1.680689e-04 -1.761241e-04 -1.845673e-04 -1.934174e-04
## ASV0153     -3.507287e-04 -3.673593e-04 -3.847748e-04 -4.030120e-04
## ASV0498      3.638011e-05  3.846848e-05  4.068888e-05  4.305047e-05
## ASV0097      2.509767e-04  2.629235e-04  2.754387e-04  2.885494e-04
## ASV0104     -1.165055e-03 -1.219395e-03 -1.276216e-03 -1.335626e-03
## ASV1282      2.023075e-04  2.118302e-04  2.217957e-04  2.322241e-04
## ASV3883     -1.170002e-04 -1.225865e-04 -1.284399e-04 -1.345732e-04
## ASV0801      1.159884e-04  1.216110e-04  1.275100e-04  1.336992e-04
## ASV1611     -4.475488e-04 -4.686203e-04 -4.906723e-04 -5.137494e-04
## ASV0227     -1.612216e-04 -1.690400e-04 -1.772434e-04 -1.858512e-04
## ASV0833      1.732401e-04  1.816341e-04  1.904404e-04  1.996800e-04
## ASV0718      4.172601e-04  4.368049e-04  4.572498e-04  4.786350e-04
## ASV1139      1.545122e-04  1.614372e-04  1.686514e-04  1.761646e-04
## ASV0766     -1.143889e-04 -1.196534e-04 -1.251513e-04 -1.308922e-04
## ASV2091      5.629086e-04  5.887272e-04  6.156832e-04  6.438224e-04
## ASV1238     -3.684987e-05 -3.831026e-05 -3.981282e-05 -4.135709e-05
## ASV9193     -4.912513e-05 -5.164812e-05 -5.430803e-05 -5.711285e-05
## ASV0290     -4.590611e-05 -4.821099e-05 -5.063628e-05 -5.318862e-05
## ASV0231      4.432956e-04  4.639408e-04  4.855257e-04  5.080910e-04
## ASV0185      7.480092e-05  7.907021e-05  8.360873e-05  8.843527e-05
## ASV2330      1.284394e-04  1.343481e-04  1.405187e-04  1.469621e-04
## ASV3119     -1.435426e-04 -1.505777e-04 -1.579663e-04 -1.657267e-04
## ASV2368     -2.008700e-04 -2.104270e-04 -2.204383e-04 -2.309253e-04
## ASV0122     -1.602525e-04 -1.675610e-04 -1.751877e-04 -1.831450e-04
## ASV1044      2.749856e-04  2.882091e-04  3.020739e-04  3.166116e-04
## ASV0160     -3.958208e-04 -4.137779e-04 -4.325069e-04 -4.520370e-04
## ASV0326      2.541067e-04  2.660159e-04  2.784741e-04  2.915057e-04
## ASV1388      4.456506e-04  4.664486e-04  4.881970e-04  5.109373e-04
## ASV0792      5.062015e-04  5.296396e-04  5.541312e-04  5.797206e-04
## ASV0036     -3.177452e-04 -3.327637e-04 -3.484864e-04 -3.649459e-04
## ASV2125      5.211303e-04  5.454399e-04  5.708594e-04  5.974373e-04
## ASV1075      9.889968e-05  1.036216e-04  1.085695e-04  1.137544e-04
## ASV0390      9.601997e-05  1.007654e-04  1.057530e-04  1.109958e-04
## ASV3790     -4.176970e-04 -4.373398e-04 -4.578944e-04 -4.794020e-04
## ASV1535     -3.354217e-05 -3.521500e-05 -3.697466e-05 -3.882595e-05
## ASV0263      8.630920e-05  9.035957e-05  9.459710e-05  9.903015e-05
## ASV0675      6.842229e-04  7.167126e-04  7.507402e-04  7.863778e-04
## ASV3348      6.519813e-05  6.837029e-05  7.169987e-05  7.519495e-05
## ASV0058     -6.576552e-04 -6.882598e-04 -7.202546e-04 -7.536995e-04
## ASV4142      1.650176e-04  1.726814e-04  1.806915e-04  1.890624e-04
## ASV0059     -5.673546e-04 -5.937210e-04 -6.212817e-04 -6.500876e-04
## ASV0013     -1.182652e-03 -1.237805e-03 -1.295474e-03 -1.355771e-03
## ASV0033     -3.458127e-04 -3.621791e-04 -3.793151e-04 -3.972562e-04
## ASV4354     -1.520636e-04 -1.590510e-04 -1.663478e-04 -1.739667e-04
## ASV0022     -3.649971e-04 -3.822504e-04 -4.003130e-04 -4.192220e-04
## ASV0134     -8.988189e-05 -9.424863e-05 -9.883102e-05 -1.036400e-04
## ASV0415     -7.849442e-05 -8.184613e-05 -8.532194e-05 -8.892460e-05
## ASV10103    -2.557879e-04 -2.678207e-04 -2.804123e-04 -2.935881e-04
## ASV1613      4.158359e-04  4.350781e-04  4.551839e-04  4.761897e-04
## ASV0135     -2.448132e-05 -2.523818e-05 -2.599284e-05 -2.674169e-05
## ASV0469     -5.190968e-04 -5.430677e-04 -5.681102e-04 -5.942690e-04
## ASV0471      3.282523e-04  3.436432e-04  3.597441e-04  3.765865e-04
## ASV0451     -8.868949e-05 -9.301760e-05 -9.756149e-05 -1.023323e-04
## ASV0747      1.264119e-04  1.325351e-04  1.389592e-04  1.456993e-04
## ASV1314     -1.939601e-04 -2.032913e-04 -2.130758e-04 -2.233358e-04
## ASV0425     -5.907300e-04 -6.177929e-04 -6.460448e-04 -6.755331e-04
## ASV0559     -3.361905e-04 -3.515744e-04 -3.676331e-04 -3.843937e-04
## ASV0148     -3.648137e-04 -3.814721e-04 -3.988570e-04 -4.169968e-04
## ASV0129     -1.826182e-04 -1.907267e-04 -1.991664e-04 -2.079480e-04
## ASV1072      1.773441e-04  1.854047e-04  1.938130e-04  2.025825e-04
## ASV2390      1.264589e-04  1.322089e-04  1.382072e-04  1.444632e-04
## ASV0548      3.780080e-04  3.957685e-04  4.143520e-04  4.337956e-04
## ASV0168     -5.719047e-04 -5.983907e-04 -6.260680e-04 -6.549869e-04
## ASV0066     -4.235577e-04 -4.432499e-04 -4.638350e-04 -4.853512e-04
## ASV0468     -1.561654e-04 -1.634677e-04 -1.711051e-04 -1.790923e-04
## ASV0172     -9.118587e-05 -9.503860e-05 -9.902925e-05 -1.031602e-04
## ASV0236     -2.233100e-04 -2.331788e-04 -2.434462e-04 -2.541249e-04
## ASV0250      7.355427e-06  8.331237e-06  9.411798e-06  1.060739e-05
## ASV0338     -3.323023e-05 -3.443120e-05 -3.565447e-05 -3.689803e-05
## ASV0450     -2.033315e-06 -2.121965e-06 -2.214040e-06 -2.309627e-06
## ASV0377      4.646229e-04  4.863202e-04  5.090106e-04  5.327375e-04
## ASV1022      1.291269e-04  1.351884e-04  1.415305e-04  1.481656e-04
## ASV6174     -3.216911e-05 -3.363535e-05 -3.516553e-05 -3.676219e-05
## ASV0786      5.261759e-05  5.497597e-05  5.743310e-05  5.999251e-05
## ASV0053     -5.586863e-04 -5.848259e-04 -6.121664e-04 -6.407609e-04
## ASV0697     -1.633008e-04 -1.707007e-04 -1.784180e-04 -1.864648e-04
## ASV0785      4.160522e-04  4.354990e-04  4.558372e-04  4.771064e-04
## ASV1967     -2.766104e-04 -2.892590e-04 -3.024617e-04 -3.162406e-04
## ASV0385     -1.297452e-04 -1.355937e-04 -1.416901e-04 -1.480434e-04
## ASV0295     -9.375555e-07 -6.464610e-07 -3.101250e-07  7.646991e-08
## ASV0072     -4.484342e-04 -4.690189e-04 -4.905115e-04 -5.129488e-04
## ASV0157     -1.871934e-04 -1.956268e-04 -2.044167e-04 -2.135757e-04
## ASV0501      2.018399e-04  2.115161e-04  2.216589e-04  2.322911e-04
## ASV10729    -3.398636e-04 -3.558426e-04 -3.725630e-04 -3.900580e-04
## ASV1470      1.625714e-04  1.700626e-04  1.778871e-04  1.860585e-04
## ASV0050     -1.117862e-03 -1.169806e-03 -1.224103e-03 -1.280852e-03
## ASV0411     -2.986518e-05 -3.110355e-05 -3.238370e-05 -3.370606e-05
## ASV0549      2.104222e-04  2.204706e-04  2.310001e-04  2.420338e-04
## ASV0184      1.302977e-04  1.363794e-04  1.427393e-04  1.493898e-04
## ASV0705      1.562653e-04  1.636768e-04  1.714381e-04  1.795653e-04
## ASV1715      3.957178e-04  4.142675e-04  4.336729e-04  4.539721e-04
## ASV0603      4.672671e-05  4.896513e-05  5.131145e-05  5.377096e-05
## ASV0826      1.335507e-04  1.396568e-04  1.460300e-04  1.526808e-04
## ASV0034     -5.060368e-04 -5.294184e-04 -5.538460e-04 -5.793632e-04
## ASV0838      1.066274e-04  1.115718e-04  1.167390e-04  1.221381e-04
## ASV0614     -2.873899e-04 -3.007020e-04 -3.146130e-04 -3.291484e-04
## ASV0014     -1.083396e-03 -1.133773e-03 -1.186434e-03 -1.241479e-03
## ASV0585     -6.780625e-05 -7.100867e-05 -7.436102e-05 -7.787019e-05
## ASV0016     -1.107436e-03 -1.158948e-03 -1.212799e-03 -1.269088e-03
## ASV5394     -2.800596e-04 -2.932099e-04 -3.069687e-04 -3.213632e-04
## ASV0666      2.388248e-04  2.499255e-04  2.615292e-04  2.736575e-04
## ASV2085      9.628359e-05  1.003894e-04  1.046465e-04  1.090581e-04
## ASV0003     -1.013394e-03 -1.060455e-03 -1.109644e-03 -1.161052e-03
## ASV0346     -2.156110e-05 -2.216907e-05 -2.276737e-05 -2.335208e-05
## ASV0267     -1.616380e-04 -1.689463e-04 -1.765659e-04 -1.845083e-04
## ASV0353      2.133472e-04  2.237161e-04  2.345979e-04  2.460188e-04
## ASV2419      2.864452e-04  2.996999e-04  3.135499e-04  3.280200e-04
## ASV0447      1.329494e-04  1.396020e-04  1.466008e-04  1.539647e-04
## ASV0654      4.411827e-04  4.619820e-04  4.837514e-04  5.065351e-04
## ASV0151      6.719426e-05  7.060938e-05  7.420747e-05  7.799913e-05
## ASV0065     -4.088024e-04 -4.278305e-04 -4.477234e-04 -4.685183e-04
## ASV0527      2.957606e-04  3.095422e-04  3.239518e-04  3.390164e-04
## ASV4055     -1.097865e-04 -1.150460e-04 -1.205589e-04 -1.263375e-04
## ASV0166     -3.418838e-04 -3.575792e-04 -3.739674e-04 -3.910765e-04
## ASV0417     -2.881613e-04 -3.015007e-04 -3.154395e-04 -3.300031e-04
## ASV0078     -2.317092e-04 -2.423375e-04 -2.534338e-04 -2.650167e-04
## ASV0322     -2.819676e-04 -2.948979e-04 -3.083973e-04 -3.224886e-04
## ASV0156     -3.653889e-04 -3.822651e-04 -3.998963e-04 -4.183139e-04
## ASV0648     -3.280171e-04 -3.434973e-04 -3.597011e-04 -3.766619e-04
## ASV0407      2.472550e-05  2.599212e-05  2.732743e-05  2.873548e-05
## ASV2030     -7.114928e-05 -7.431224e-05 -7.760559e-05 -8.103378e-05
## ASV0300      1.909242e-04  2.001648e-04  2.098588e-04  2.200292e-04
## ASV1150     -2.555215e-05 -2.663153e-05 -2.774936e-05 -2.890630e-05
## ASV0958      1.993858e-04  2.090255e-04  2.191378e-04  2.297465e-04
## ASV0216     -3.482519e-04 -3.641967e-04 -3.808416e-04 -3.982145e-04
## ASV0446      4.792137e-04  5.020641e-04  5.260044e-04  5.510866e-04
## ASV0367     -1.653784e-04 -1.730699e-04 -1.811105e-04 -1.895153e-04
## ASV0200     -3.077380e-04 -3.221263e-04 -3.371750e-04 -3.529132e-04
## ASV0334     -1.617926e-04 -1.688587e-04 -1.762023e-04 -1.838311e-04
## ASV1311      2.176322e-04  2.277143e-04  2.382502e-04  2.492589e-04
## ASV0458      2.349275e-04  2.458450e-04  2.572575e-04  2.691864e-04
## ASV1371      7.026255e-06  7.372497e-06  7.736342e-06  8.118732e-06
## ASV0418      2.864132e-04  2.998022e-04  3.138054e-04  3.284500e-04
## ASV0004      3.402607e-04  3.561303e-04  3.727242e-04  3.900740e-04
## ASV1943      2.493370e-04  2.608349e-04  2.728459e-04  2.853914e-04
## ASV1495     -5.967789e-05 -6.272781e-05 -6.594234e-05 -6.933107e-05
## ASV0901     -3.861340e-04 -4.044089e-04 -4.235435e-04 -4.435775e-04
## ASV0628      2.272675e-04  2.377389e-04  2.486759e-04  2.600976e-04
## ASV0400      9.101363e-05  9.521321e-05  9.960003e-05  1.041818e-04
## ASV0116     -2.967720e-04 -3.109381e-04 -3.257817e-04 -3.413352e-04
## ASV0788      2.457799e-04  2.572923e-04  2.693349e-04  2.819312e-04
## ASV0117      1.570840e-04  1.646559e-04  1.725969e-04  1.809254e-04
## ASV3137      4.345495e-05  4.545672e-05  4.754754e-05  4.973108e-05
## ASV0001      4.100294e-04  4.288261e-04  4.484498e-04  4.689337e-04
## ASV1651      2.734735e-04  2.860076e-04  2.990933e-04  3.127526e-04
## ASV1692      2.891764e-04  3.029669e-04  3.174156e-04  3.325539e-04
## ASV0660      1.681669e-04  1.757601e-04  1.836759e-04  1.919259e-04
## ASV0508      2.106625e-05  2.194203e-05  2.284802e-05  2.378467e-05
## ASV1660     -1.184164e-04 -1.241327e-04 -1.301279e-04 -1.364159e-04
## ASV0233      6.586369e-05  6.904697e-05  7.238634e-05  7.588965e-05
## ASV1343     -2.920811e-04 -3.058204e-04 -3.201979e-04 -3.352427e-04
## ASV0209      2.723785e-04  2.848143e-04  2.977926e-04  3.113348e-04
## ASV0193     -3.537082e-04 -3.699964e-04 -3.870084e-04 -4.047740e-04
## ASV0357     -2.182172e-05 -2.259511e-05 -2.338032e-05 -2.417562e-05
## ASV0198      7.520496e-05  7.875285e-05  8.246650e-05  8.635350e-05
## ASV0007      3.887004e-04  4.065186e-04  4.251206e-04  4.445381e-04
## ASV1772     -3.971967e-05 -4.155222e-05 -4.346635e-05 -4.546538e-05
## ASV0009      3.667816e-04  3.835726e-04  4.011002e-04  4.193938e-04
## ASV0006      1.485880e-04  1.551653e-04  1.620095e-04  1.691291e-04
## ASV0011     -4.078532e-04 -4.271010e-04 -4.472487e-04 -4.683377e-04
## ASV0015      2.859403e-04  2.992914e-04  3.132531e-04  3.278523e-04
## ASV0017      3.028593e-04  3.169808e-04  3.317463e-04  3.471840e-04
## ASV0235     -2.382191e-04 -2.494516e-04 -2.612082e-04 -2.735127e-04
## ASV0382      4.098276e-05  4.325756e-05  4.567020e-05  4.822982e-05
## ASV2357      3.625900e-04  3.796161e-04  3.974304e-04  4.160684e-04
## ASV0567     -2.640560e-04 -2.762788e-04 -2.890511e-04 -3.023962e-04
## ASV0165      2.884744e-04  3.019456e-04  3.160333e-04  3.307646e-04
## ASV0005      5.821466e-04  6.091232e-04  6.373142e-04  6.667712e-04
## ASV0384     -2.844471e-05 -2.955904e-05 -3.070377e-05 -3.187824e-05
## ASV0002      1.236122e-04  1.295600e-04  1.357967e-04  1.423366e-04
## ASV3017      3.398524e-04  3.555174e-04  3.718796e-04  3.889680e-04
## ASV0091      1.297906e-04  1.359551e-04  1.424114e-04  1.491733e-04
## ASV0186     -3.491545e-04 -3.655637e-04 -3.827337e-04 -4.006985e-04
## ASV0370      3.530195e-05  3.700976e-05  3.880130e-05  4.068075e-05
## ASV0018      6.061712e-04  6.343035e-04  6.637064e-04  6.944341e-04
## ASV1377      5.294868e-04  5.540119e-04  5.796404e-04  6.064190e-04
## ASV0019      6.069340e-04  6.351063e-04  6.645514e-04  6.953237e-04
## ASV0023      4.368187e-05  4.536278e-05  4.708677e-05  4.885259e-05
## ASV2194      1.968960e-04  2.062322e-04  2.160094e-04  2.262481e-04
## ASV1155     -2.305031e-05 -2.396511e-05 -2.490599e-05 -2.587256e-05
## ASV0510     -2.245209e-04 -2.345921e-04 -2.450850e-04 -2.560146e-04
## ASV2371     -2.197196e-04 -2.296986e-04 -2.401084e-04 -2.509657e-04
## ASV0024      1.460582e-05  1.492553e-05  1.522572e-05  1.550235e-05
## ASV2452      2.859705e-04  2.990772e-04  3.127599e-04  3.270416e-04
## ASV2332      1.316166e-05  1.412888e-05  1.517289e-05  1.630000e-05
## ASV2591      1.181586e-05  1.272271e-05  1.370366e-05  1.476489e-05
## ASV0521      3.874820e-04  4.058787e-04  4.251460e-04  4.453248e-04
## ASV5542      1.197198e-04  1.254945e-04  1.315502e-04  1.379006e-04
## ASV0336     -1.825460e-04 -1.910443e-04 -1.999292e-04 -2.092172e-04
## ASV10102     2.692688e-04  2.819828e-04  2.952917e-04  3.092225e-04
## ASV16823    -2.130059e-04 -2.226305e-04 -2.326661e-04 -2.431281e-04
## ASV3104      2.129888e-04  2.226118e-04  2.326457e-04  2.431058e-04
## ASV0781      1.025437e-04  1.072916e-04  1.122528e-04  1.174361e-04
## ASV10899     9.755427e-05  1.024411e-04  1.075824e-04  1.129924e-04
## ASV11222    -2.129772e-04 -2.225992e-04 -2.326320e-04 -2.430909e-04
## ASV11327    -2.129601e-04 -2.225805e-04 -2.326116e-04 -2.430686e-04
## ASV12458    -2.129430e-04 -2.225618e-04 -2.325911e-04 -2.430463e-04
## ASV1636     -1.741908e-04 -1.820424e-04 -1.902271e-04 -1.987572e-04
## ASV1890     -2.119600e-04 -2.216004e-04 -2.316586e-04 -2.421511e-04
## ASV2898      4.573101e-04  4.784708e-04  5.005812e-04  5.236814e-04
## ASV8328     -3.664454e-05 -3.795681e-05 -3.929213e-05 -4.064814e-05
## ASV0709     -3.737528e-04 -3.910927e-04 -4.092150e-04 -4.281528e-04
## ASV0856      5.920864e-05  6.211700e-05  6.517183e-05  6.838079e-05
## ASV0909     -1.592797e-04 -1.662514e-04 -1.734982e-04 -1.810280e-04
## ASV0937     -2.910905e-04 -3.047488e-04 -3.190390e-04 -3.339895e-04
## ASV11390    -2.129063e-04 -2.225218e-04 -2.325474e-04 -2.429986e-04
## ASV11966     1.076548e-04  1.129161e-04  1.184398e-04  1.242395e-04
## ASV12990     5.757932e-05  6.031176e-05  6.317280e-05  6.616834e-05
## ASV14797     2.198870e-04  2.299795e-04  2.405170e-04  2.515175e-04
## ASV14904    -2.129014e-04 -2.225165e-04 -2.325417e-04 -2.429925e-04
## ASV15304     5.662779e-05  5.954565e-05  6.262228e-05  6.586692e-05
## ASV16696    -2.128873e-04 -2.225011e-04 -2.325250e-04 -2.429742e-04
## ASV1690      1.093110e-04  1.147277e-04  1.204208e-04  1.264050e-04
## ASV2029      5.867279e-04  6.139885e-04  6.424836e-04  6.722660e-04
## ASV2834      3.140442e-04  3.287564e-04  3.441466e-04  3.602450e-04
## ASV4003      8.915671e-05  9.370552e-05  9.849841e-05  1.035494e-04
## ASV4064      2.194167e-04  2.298142e-04  2.407014e-04  2.521010e-04
## ASV4294      7.538644e-05  7.919577e-05  8.320646e-05  8.742983e-05
## ASV4609     -8.965579e-06 -9.287832e-06 -9.616221e-06 -9.950273e-06
## ASV6283     -2.128846e-04 -2.224984e-04 -2.325221e-04 -2.429713e-04
## ASV6491     -2.128675e-04 -2.224797e-04 -2.325017e-04 -2.429491e-04
## ASV7453      8.317623e-05  8.737080e-05  9.178612e-05  9.643451e-05
## ASV7959      1.599075e-05  1.704288e-05  1.817133e-05  1.938202e-05
## ASV8219      2.128554e-04  2.224665e-04  2.324875e-04  2.429336e-04
## ASV8547     -2.128383e-04 -2.224478e-04 -2.324671e-04 -2.429113e-04
## ASV9319      1.431235e-04  1.499454e-04  1.570923e-04  1.645794e-04
## ASV9382     -2.128278e-04 -2.224364e-04 -2.324546e-04 -2.428977e-04
## ASV11516    -2.128107e-04 -2.224177e-04 -2.324342e-04 -2.428755e-04
## ASV14377    -2.127936e-04 -2.223990e-04 -2.324138e-04 -2.428532e-04
## ASV1867      3.102644e-04  3.249140e-04  3.402489e-04  3.563006e-04
## ASV1895     -7.262899e-05 -7.587866e-05 -7.926409e-05 -8.279007e-05
## ASV3168      1.325358e-04  1.386519e-04  1.450402e-04  1.517117e-04
## ASV4449      2.646798e-04  2.767707e-04  2.893906e-04  3.025606e-04
## ASV6596      1.509771e-04  1.583534e-04  1.660979e-04  1.742298e-04
## ASV7492     -7.984200e-05 -8.319378e-05 -8.666430e-05 -9.025564e-05
## ASV9854     -1.096605e-04 -1.145446e-04 -1.196308e-04 -1.249262e-04
## ASV6296      2.127573e-04  2.223595e-04  2.323707e-04  2.428063e-04
## ASV4201      6.871696e-05  7.236986e-05  7.623122e-05  8.031395e-05
## ASV0552      5.190768e-04  5.436143e-04  5.693028e-04  5.961953e-04
## ASV3671     -4.415401e-05 -4.593583e-05 -4.777373e-05 -4.966791e-05
## ASV3529     -4.727288e-05 -4.911334e-05 -5.100450e-05 -5.294560e-05
## ASV1060      1.306787e-04  1.368760e-04  1.433661e-04  1.501628e-04
## ASV0239     -2.968369e-04 -3.103176e-04 -3.243792e-04 -3.390440e-04
## ASV5711     -2.729464e-04 -2.854069e-04 -2.984116e-04 -3.119823e-04
## ASV4152     -3.602098e-04 -3.768695e-04 -3.942771e-04 -4.124643e-04
## ASV1461      3.215725e-04  3.362378e-04  3.515409e-04  3.675067e-04
## ASV2877      2.617721e-04  2.739176e-04  2.866110e-04  2.998754e-04
## ASV0012      1.957117e-04  2.050744e-04  2.148868e-04  2.251705e-04
## ASV9823      7.132934e-05  7.453134e-05  7.786752e-05  8.134259e-05
## ASV0008      2.139637e-04  2.241489e-04  2.348186e-04  2.459958e-04
## ASV7832     -2.218501e-04 -2.320434e-04 -2.426885e-04 -2.538038e-04
## ASV1915      1.710049e-05  1.806029e-05  1.907860e-05  2.015924e-05
## ASV0055      1.524161e-04  1.595208e-04  1.669494e-04  1.747157e-04
## ASV0032      3.692809e-04  3.862865e-04  4.040480e-04  4.225963e-04
## ASV2977     -3.033548e-04 -3.173795e-04 -3.320333e-04 -3.473428e-04
## ASV0466      3.077837e-04  3.218581e-04  3.365488e-04  3.518801e-04
## ASV3866      3.230709e-04  3.382893e-04  3.542165e-04  3.708847e-04
## ASV0040      4.292567e-04  4.495914e-04  4.708841e-04  4.931794e-04
## ASV0496     -2.229350e-05 -2.364094e-05 -2.507894e-05 -2.661420e-05
## ASV0052      5.240226e-04  5.483605e-04  5.737995e-04  6.003867e-04
## ASV3828     -3.229940e-04 -3.378883e-04 -3.534476e-04 -3.696995e-04
## ASV1930      2.010385e-04  2.104591e-04  2.203132e-04  2.306200e-04
## ASV2126      3.271504e-04  3.423882e-04  3.583192e-04  3.749734e-04
## ASV0793      1.956426e-04  2.051193e-04  2.150617e-04  2.254933e-04
## ASV0299     -1.380079e-04 -1.441258e-04 -1.504934e-04 -1.571190e-04
## ASV0208      3.041199e-04  3.186092e-04  3.337889e-04  3.496919e-04
## ASV0511     -1.672860e-04 -1.746983e-04 -1.824119e-04 -1.904363e-04
## ASV1123     -2.198381e-04 -2.297842e-04 -2.401553e-04 -2.509676e-04
## ASV0099     -1.205139e-04 -1.260684e-04 -1.318696e-04 -1.379275e-04
## ASV0752     -2.431394e-05 -2.561062e-05 -2.698129e-05 -2.843049e-05
## ASV0883      2.949727e-06  3.185102e-06  3.440236e-06  3.716803e-06
## ASV0683      2.717117e-04  2.846415e-04  2.981856e-04  3.123732e-04
## ASV4117     -3.250497e-04 -3.400608e-04 -3.557441e-04 -3.721276e-04
## ASV2172      1.211109e-04  1.267958e-04  1.327435e-04  1.389655e-04
## ASV0330     -2.199399e-04 -2.302713e-04 -2.410811e-04 -2.523907e-04
## ASV0728      2.083182e-04  2.182711e-04  2.287000e-04  2.396276e-04
## ASV0499      4.100526e-04  4.295565e-04  4.499870e-04  4.713877e-04
## ASV0120     -4.567766e-04 -4.781082e-04 -5.004154e-04 -5.237411e-04
## ASV1446      3.862186e-05  4.018237e-05  4.179167e-05  4.344983e-05
## ASV17171    -3.086332e-04 -3.229204e-04 -3.378507e-04 -3.534512e-04
## ASV0533      8.695552e-05  9.113135e-05  9.550929e-05  1.000992e-04
## ASV2495     -1.245921e-04 -1.304856e-04 -1.366568e-04 -1.431188e-04
## ASV5582      1.095926e-04  1.145049e-04  1.196224e-04  1.249524e-04
## ASV1488      9.879920e-05  1.035245e-04  1.084764e-04  1.136659e-04
## ASV0682      2.855052e-04  2.990808e-04  3.133008e-04  3.281957e-04
## ASV0068     -1.640046e-05 -1.740873e-05 -1.848581e-05 -1.963682e-05
## ASV1987     -1.540782e-04 -1.615850e-04 -1.694645e-04 -1.777357e-04
## ASV0035      5.540431e-05  5.760685e-05  5.987323e-05  6.220271e-05
## ASV7192     -2.084737e-04 -2.179615e-04 -2.278606e-04 -2.381872e-04
## ASV0873      3.132249e-05  3.256414e-05  3.384246e-05  3.515726e-05
## ASV4749      1.874192e-05  1.924469e-05  1.973514e-05  2.020936e-05
## ASV2174      1.983841e-04  2.073545e-04  2.167081e-04  2.264591e-04
## ASV1476     -1.712850e-04 -1.793038e-04 -1.876922e-04 -1.964668e-04
## ASV0740     -4.156101e-04 -4.353373e-04 -4.559974e-04 -4.776342e-04
## ASV0170      8.866853e-05  9.281207e-05  9.714571e-05  1.016778e-04
## ASV2466     -3.788996e-04 -3.965544e-04 -4.150143e-04 -4.343147e-04
## ASV1709      2.944336e-04  3.080728e-04  3.223264e-04  3.372204e-04
## ASV6170     -2.699244e-04 -2.826355e-04 -2.959382e-04 -3.098596e-04
## ASV3673      3.089249e-04  3.234841e-04  3.387221e-04  3.546699e-04
## ASV1745      2.368938e-05  2.481568e-05  2.599531e-05  2.723077e-05
##                                                                    
## (Intercept) -2.666280e-06 -3.048378e-06 -3.484315e-06 -3.981496e-06
## ASV1236      2.669649e-04  2.791447e-04  2.918551e-04  3.051169e-04
## ASV0421     -4.746486e-04 -4.963983e-04 -5.191044e-04 -5.428053e-04
## ASV0691     -4.138812e-04 -4.324886e-04 -4.518810e-04 -4.720867e-04
## ASV0899     -6.290428e-06 -6.342522e-06 -6.375389e-06 -6.386336e-06
## ASV1004      5.394410e-04  5.641775e-04  5.900032e-04  6.169617e-04
## ASV1041     -3.651229e-04 -3.818825e-04 -3.993812e-04 -4.176486e-04
## ASV1058      5.014263e-04  5.244233e-04  5.484335e-04  5.734978e-04
## ASV12542     1.542314e-04  1.611356e-04  1.683282e-04  1.758194e-04
## ASV1294      5.827925e-04  6.096892e-04  6.377867e-04  6.671347e-04
## ASV13113     2.089811e-04  2.189426e-04  2.293794e-04  2.403143e-04
## ASV1318      5.082638e-04  5.315949e-04  5.559554e-04  5.813871e-04
## ASV2269     -1.513812e-04 -1.583451e-04 -1.656174e-04 -1.732105e-04
## ASV2542      3.263957e-04  3.418190e-04  3.579651e-04  3.748674e-04
## ASV2660     -2.932016e-04 -3.065488e-04 -3.204743e-04 -3.350003e-04
## ASV2737     -1.512073e-05 -1.593746e-05 -1.680133e-05 -1.771524e-05
## ASV2840      3.903215e-04  4.080181e-04  4.264746e-04  4.457198e-04
## ASV3053      2.121048e-05  2.213254e-05  2.309083e-05  2.408644e-05
## ASV3077      1.215160e-04  1.270445e-04  1.328127e-04  1.388299e-04
## ASV3134      4.209917e-04  4.409880e-04  4.619317e-04  4.838675e-04
## ASV3140      1.848725e-04  1.935918e-04  2.027176e-04  2.122685e-04
## ASV3579      7.423768e-05  7.796200e-05  8.188136e-05  8.600664e-05
## ASV6119     -1.513521e-04 -1.583133e-04 -1.655826e-04 -1.731725e-04
## ASV7557     -1.513372e-04 -1.582970e-04 -1.655647e-04 -1.731530e-04
## ASV8422      8.423020e-05  8.800153e-05  9.193083e-05  9.602377e-05
## ASV1086     -4.231224e-05 -4.419921e-05 -4.616463e-05 -4.821127e-05
## ASV1310      2.883378e-04  3.016651e-04  3.155890e-04  3.301344e-04
## ASV15750    -7.172692e-05 -7.499016e-05 -7.839421e-05 -8.194440e-05
## ASV16905    -1.513315e-04 -1.582908e-04 -1.655579e-04 -1.731455e-04
## ASV2033      2.849592e-04  2.984815e-04  3.126428e-04  3.274733e-04
## ASV2089      1.036146e-04  1.083963e-04  1.133910e-04  1.186075e-04
## ASV2127      4.144111e-04  4.334709e-04  4.533754e-04  4.741592e-04
## ASV2725      4.692668e-04  4.905930e-04  5.128404e-04  5.360442e-04
## ASV2804     -1.513278e-04 -1.582868e-04 -1.655536e-04 -1.731408e-04
## ASV3075      2.974819e-04  3.112456e-04  3.256281e-04  3.406554e-04
## ASV3327      2.783984e-04  2.915467e-04  3.053110e-04  3.197195e-04
## ASV3342      3.032596e-04  3.174739e-04  3.323433e-04  3.478972e-04
## ASV3532     -2.736339e-04 -2.864450e-04 -2.998454e-04 -3.138613e-04
## ASV3600      3.469991e-04  3.632003e-04  3.801430e-04  3.978598e-04
## ASV4013      2.918521e-04  3.053115e-04  3.193711e-04  3.340555e-04
## ASV4136      2.895936e-04  3.028101e-04  3.166028e-04  3.309945e-04
## ASV4195      1.513064e-04  1.582633e-04  1.655280e-04  1.731128e-04
## ASV4407     -1.512915e-04 -1.582470e-04 -1.655101e-04 -1.730933e-04
## ASV4717      8.626864e-06  8.910519e-06  9.196584e-06  9.484270e-06
## ASV6794      1.565553e-04  1.635799e-04  1.709000e-04  1.785264e-04
## ASV8324     -1.512875e-04 -1.582426e-04 -1.655053e-04 -1.730879e-04
## ASV8981     -4.065669e-05 -4.237660e-05 -4.415798e-05 -4.600188e-05
## ASV9859      1.160401e-04  1.217189e-04  1.276827e-04  1.339463e-04
## ASV0936     -2.377086e-04 -2.486643e-04 -2.601079e-04 -2.720597e-04
## ASV12683    -2.431256e-05 -2.552303e-05 -2.679540e-05 -2.813293e-05
## ASV1293      3.509082e-04  3.669764e-04  3.837498e-04  4.012566e-04
## ASV13055    -3.691314e-05 -3.855852e-05 -4.027144e-05 -4.205410e-05
## ASV17063    -1.512617e-04 -1.582144e-04 -1.654745e-04 -1.730544e-04
## ASV2228      1.512467e-04  1.581981e-04  1.654567e-04  1.730349e-04
## ASV2769     -2.800537e-05 -2.915120e-05 -3.033409e-05 -3.155424e-05
## ASV2803      7.227318e-05  7.548346e-05  7.882578e-05  8.230462e-05
## ASV2896      1.903431e-04  1.992330e-04  2.085309e-04  2.182547e-04
## ASV3062      5.812988e-05  6.105311e-05  6.413007e-05  6.736940e-05
## ASV3107      2.292565e-04  2.399696e-04  2.511741e-04  2.628915e-04
## ASV3265      4.563938e-04  4.772728e-04  4.990666e-04  5.218114e-04
## ASV3666     -1.032924e-05 -1.083959e-05 -1.137579e-05 -1.193920e-05
## ASV4497      1.081419e-04  1.130969e-04  1.182700e-04  1.236700e-04
## ASV6914     -5.297168e-05 -5.546552e-05 -5.807502e-05 -6.080534e-05
## ASV0576     -5.391843e-04 -5.635349e-04 -5.889233e-04 -6.153880e-04
## ASV0673      1.396251e-04  1.463461e-04  1.533928e-04  1.607810e-04
## ASV0772      1.631930e-04  1.707546e-04  1.786570e-04  1.869150e-04
## ASV0862     -1.311364e-04 -1.369605e-04 -1.430232e-04 -1.493323e-04
## ASV0898      1.346484e-04  1.411451e-04  1.479584e-04  1.551037e-04
## ASV0910      2.912881e-04  3.051759e-04  3.197262e-04  3.349703e-04
## ASV0964     -1.952226e-04 -2.040867e-04 -2.133329e-04 -2.229759e-04
## ASV10059     1.362335e-04  1.427612e-04  1.496037e-04  1.567763e-04
## ASV10263    -1.513281e-04 -1.582872e-04 -1.655542e-04 -1.731417e-04
## ASV1088      1.547369e-04  1.621313e-04  1.698806e-04  1.780019e-04
## ASV1101      2.629971e-04  2.751848e-04  2.879209e-04  3.012283e-04
## ASV1183      1.681548e-04  1.760137e-04  1.842324e-04  1.928267e-04
## ASV11956     6.580344e-05  6.868127e-05  7.167313e-05  7.478248e-05
## ASV12774    -2.276021e-05 -2.388298e-05 -2.506241e-05 -2.630142e-05
## ASV1321      6.681250e-05  7.021012e-05  7.378942e-05  7.756084e-05
## ASV13793    -1.513108e-04 -1.582683e-04 -1.655335e-04 -1.731190e-04
## ASV14482    -1.377974e-05 -1.450363e-05 -1.526754e-05 -1.607380e-05
## ASV15483     1.066893e-04  1.117036e-04  1.169508e-04  1.224414e-04
## ASV2062      6.689824e-04  7.000032e-04  7.324229e-04  7.663010e-04
## ASV2132      3.045119e-04  3.188401e-04  3.338344e-04  3.495252e-04
## ASV2413      4.326565e-04  4.525111e-04  4.732421e-04  4.948850e-04
## ASV2490      2.847984e-04  2.977337e-04  3.112269e-04  3.252996e-04
## ASV2594      1.563794e-04  1.636373e-04  1.712240e-04  1.791540e-04
## ASV2822     -1.513355e-04 -1.582953e-04 -1.655631e-04 -1.731514e-04
## ASV2863      2.642207e-04  2.762935e-04  2.888940e-04  3.020429e-04
## ASV2910      3.445901e-04  3.603067e-04  3.767079e-04  3.938203e-04
## ASV2980      1.247977e-04  1.305065e-04  1.364650e-04  1.426830e-04
## ASV3307      1.513106e-04  1.582681e-04  1.655333e-04  1.731188e-04
## ASV3474      2.374465e-04  2.487927e-04  2.606825e-04  2.731419e-04
## ASV3502      4.940966e-04  5.170544e-04  5.410523e-04  5.661348e-04
## ASV4236      2.505876e-04  2.619726e-04  2.738489e-04  2.862355e-04
## ASV4842     -8.259095e-05 -8.642618e-05 -9.043430e-05 -9.462257e-05
## ASV4894     -1.513279e-04 -1.582871e-04 -1.655541e-04 -1.731417e-04
## ASV5290      1.866027e-04  1.952816e-04  2.043543e-04  2.138378e-04
## ASV5501      3.498424e-05  3.659767e-05  3.828352e-05  4.004490e-05
## ASV5795      1.257380e-04  1.316884e-04  1.379186e-04  1.444418e-04
## ASV5987     -1.513338e-04 -1.582936e-04 -1.655613e-04 -1.731496e-04
## ASV6267     -1.513189e-04 -1.582772e-04 -1.655435e-04 -1.731300e-04
## ASV6862      2.925601e-04  3.057525e-04  3.195053e-04  3.338393e-04
## ASV7145      5.378337e-05  5.616083e-05  5.863532e-05  6.121011e-05
## ASV7673     -1.513149e-04 -1.582729e-04 -1.655386e-04 -1.731247e-04
## ASV7789      5.503483e-05  5.783493e-05  6.078526e-05  6.389452e-05
## ASV7809     -1.873971e-05 -1.946355e-05 -2.020605e-05 -2.096668e-05
## ASV8002     -1.513036e-04 -1.582606e-04 -1.655253e-04 -1.731102e-04
## ASV8205      8.824470e-05  9.234797e-05  9.663791e-05  1.011227e-04
## ASV9155     -1.139632e-04 -1.191854e-04 -1.246368e-04 -1.303266e-04
## ASV9221     -1.734227e-05 -1.798048e-05 -1.863135e-05 -1.929386e-05
## ASV9311     -1.512836e-04 -1.582386e-04 -1.655013e-04 -1.730841e-04
## ASV9557     -1.512686e-04 -1.582223e-04 -1.654835e-04 -1.730646e-04
## ASV9936     -1.512537e-04 -1.582060e-04 -1.654656e-04 -1.730450e-04
## ASV1445      3.498813e-04  3.663025e-04  3.834832e-04  4.014575e-04
## ASV4232      2.955907e-04  3.096320e-04  3.243391e-04  3.397434e-04
## ASV6479     -1.412923e-06 -1.202996e-06 -9.574178e-07 -6.721902e-07
## ASV0142     -7.669053e-04 -8.018555e-04 -8.383247e-04 -8.763723e-04
## ASV0378     -2.514609e-04 -2.627907e-04 -2.746000e-04 -2.869062e-04
## ASV1122      4.623889e-04  4.841063e-04  5.068292e-04  5.306028e-04
## ASV0123     -7.512998e-04 -7.855192e-04 -8.212241e-04 -8.584722e-04
## ASV2064      7.794513e-05  8.137629e-05  8.494532e-05  8.865656e-05
## ASV4459     -8.300633e-05 -8.679877e-05 -9.075663e-05 -9.488637e-05
## ASV0448      1.318414e-04  1.383738e-04  1.452402e-04  1.524585e-04
## ASV0397      3.456358e-04  3.617727e-04  3.786476e-04  3.962927e-04
## ASV0485      4.839072e-04  5.063059e-04  5.297114e-04  5.541663e-04
## ASV1566      4.049884e-04  4.238727e-04  4.436184e-04  4.642630e-04
## ASV1365      2.624114e-04  2.746738e-04  2.874982e-04  3.009093e-04
## ASV1065      5.374405e-04  5.625295e-04  5.887655e-04  6.161989e-04
## ASV0722     -1.124468e-05 -1.169938e-05 -1.216873e-05 -1.265287e-05
## ASV12660    -2.526536e-04 -2.641245e-04 -2.760900e-04 -2.885692e-04
## ASV0223     -1.008225e-05 -1.051912e-05 -1.097265e-05 -1.144324e-05
## ASV0229      2.402490e-04  2.515834e-04  2.634474e-04  2.758653e-04
## ASV0877     -9.197276e-05 -9.604702e-05 -1.002871e-04 -1.046982e-04
## ASV0983      4.940735e-04  5.168521e-04  5.406454e-04  5.654954e-04
## ASV0626     -1.626684e-04 -1.697588e-04 -1.771267e-04 -1.847798e-04
## ASV4146     -2.713845e-05 -2.836083e-05 -2.963482e-05 -3.096230e-05
## ASV4175     -3.027821e-04 -3.168926e-04 -3.316458e-04 -3.470696e-04
## ASV2082     -2.190215e-05 -2.311803e-05 -2.440852e-05 -2.577876e-05
## ASV2272      2.186464e-04  2.289424e-04  2.397180e-04  2.509952e-04
## ASV2245     -2.636524e-04 -2.759970e-04 -2.889091e-04 -3.024139e-04
## ASV0590     -1.602780e-04 -1.680942e-04 -1.762993e-04 -1.849133e-04
## ASV0217     -2.452897e-04 -2.557762e-04 -2.666524e-04 -2.779271e-04
## ASV0416      2.463582e-04  2.573572e-04  2.688125e-04  2.807398e-04
## ASV1056      2.923053e-04  3.062948e-04  3.209562e-04  3.363220e-04
## ASV7777     -2.613475e-04 -2.735408e-04 -2.862910e-04 -2.996223e-04
## ASV0455      5.261384e-05  5.518719e-05  5.788868e-05  6.072479e-05
## ASV0604      5.698922e-05  5.995952e-05  6.309449e-05  6.640398e-05
## ASV6100     -2.413430e-04 -2.526271e-04 -2.644288e-04 -2.767708e-04
## ASV11359    -2.702021e-04 -2.827458e-04 -2.958563e-04 -3.095576e-04
## ASV6604      1.917169e-04  2.007851e-04  2.102795e-04  2.202197e-04
## ASV5004     -1.585696e-04 -1.659214e-04 -1.736045e-04 -1.816330e-04
## ASV1483     -1.462689e-04 -1.530795e-04 -1.601996e-04 -1.676427e-04
## ASV9773     -3.092081e-04 -3.236416e-04 -3.387350e-04 -3.545171e-04
## ASV4059      2.940396e-05  3.096243e-05  3.260979e-05  3.435160e-05
## ASV1193      5.034186e-04  5.268620e-04  5.513719e-04  5.769946e-04
## ASV4610     -4.433410e-05 -4.602906e-05 -4.776730e-05 -4.954767e-05
## ASV0742     -1.887222e-04 -1.969831e-04 -2.055707e-04 -2.144944e-04
## ASV1502     -2.809586e-06 -3.107845e-06 -3.435276e-06 -3.794578e-06
## ASV0195     -5.534459e-05 -5.814191e-05 -6.108667e-05 -6.418705e-05
## ASV1213      1.596865e-04  1.668602e-04  1.743354e-04  1.821230e-04
## ASV1648     -2.288740e-04 -2.395310e-04 -2.506727e-04 -2.623202e-04
## ASV6984     -1.712787e-04 -1.792971e-04 -1.876844e-04 -1.964568e-04
## ASV0396     -1.297329e-04 -1.350464e-04 -1.405339e-04 -1.461967e-04
## ASV4297      2.587981e-04  2.705654e-04  2.828417e-04  2.956467e-04
## ASV2622      5.890012e-04  6.159768e-04  6.441375e-04  6.735311e-04
## ASV3512      9.026450e-05  9.477429e-05  9.951866e-05  1.045106e-04
## ASV2411      2.019922e-04  2.116262e-04  2.217199e-04  2.322953e-04
## ASV2291     -5.121692e-05 -5.379657e-05 -5.651227e-05 -5.937171e-05
## ASV0807      2.367979e-04  2.483302e-04  2.604344e-04  2.731398e-04
## ASV1292      1.329127e-04  1.389971e-04  1.453488e-04  1.519784e-04
## ASV1035      6.231626e-05  6.506270e-05  6.792021e-05  7.089240e-05
## ASV0070     -1.398694e-04 -1.459488e-04 -1.522637e-04 -1.588201e-04
## ASV0255      5.694520e-05  5.959727e-05  6.236967e-05  6.526751e-05
## ASV0057     -6.081165e-04 -6.356110e-04 -6.642793e-04 -6.941649e-04
## ASV0077     -8.897282e-05 -9.272521e-05 -9.661141e-05 -1.006337e-04
## ASV0625      6.051233e-04  6.327245e-04  6.615274e-04  6.915790e-04
## ASV2464      2.931398e-04  3.063684e-04  3.201605e-04  3.345369e-04
## ASV1315      5.262504e-04  5.512204e-04  5.773703e-04  6.047554e-04
## ASV2673      3.829800e-04  4.012379e-04  4.203669e-04  4.404086e-04
## ASV2161      1.577501e-04  1.652971e-04  1.732068e-04  1.814967e-04
## ASV0337     -2.530181e-04 -2.647180e-04 -2.769423e-04 -2.897131e-04
## ASV7680     -2.972014e-04 -3.111059e-04 -3.256489e-04 -3.408587e-04
## ASV0611      6.465198e-04  6.770090e-04  7.089223e-04  7.423250e-04
## ASV3118     -2.196442e-04 -2.299839e-04 -2.408043e-04 -2.521273e-04
## ASV1284      2.318923e-04  2.427947e-04  2.542030e-04  2.661399e-04
## ASV0889      1.767885e-04  1.849395e-04  1.934542e-04  2.023478e-04
## ASV4649     -1.845061e-04 -1.931030e-04 -2.020913e-04 -2.114879e-04
## ASV1108     -2.358143e-04 -2.470990e-04 -2.589257e-04 -2.713208e-04
## ASV0738     -3.644804e-05 -3.742805e-05 -3.838526e-05 -3.931239e-05
## ASV0473      3.634361e-05  3.805074e-05  3.983724e-05  4.170674e-05
## ASV0598     -2.680783e-04 -2.801364e-04 -2.927035e-04 -3.057979e-04
## ASV0429      4.275564e-04  4.473158e-04  4.679598e-04  4.895250e-04
## ASV1549      4.265550e-04  4.469437e-04  4.683100e-04  4.907009e-04
## ASV1203      3.230700e-04  3.380583e-04  3.537231e-04  3.700932e-04
## ASV4532      1.434603e-05  1.490753e-05  1.548524e-05  1.607908e-05
## ASV0274     -3.247350e-04 -3.393790e-04 -3.546447e-04 -3.705551e-04
## ASV0163     -4.637572e-04 -4.846130e-04 -5.063487e-04 -5.289960e-04
## ASV1298      1.884323e-04  1.969017e-04  2.057283e-04  2.149250e-04
## ASV9424     -3.940764e-04 -4.125900e-04 -4.319613e-04 -4.522290e-04
## ASV0412      6.077583e-04  6.358641e-04  6.652309e-04  6.959119e-04
## ASV0284      2.720772e-04  2.843935e-04  2.972376e-04  3.106292e-04
## ASV0620     -2.026941e-04 -2.124180e-04 -2.226109e-04 -2.332956e-04
## ASV0153     -4.221092e-04 -4.421065e-04 -4.630459e-04 -4.849711e-04
## ASV0498      4.556308e-05  4.823727e-05  5.108436e-05  5.411650e-05
## ASV0097      3.022840e-04  3.166721e-04  3.317447e-04  3.475344e-04
## ASV0104     -1.397736e-03 -1.462664e-03 -1.530532e-03 -1.601465e-03
## ASV1282      2.431364e-04  2.545542e-04  2.665005e-04  2.789988e-04
## ASV3883     -1.409996e-04 -1.477334e-04 -1.547891e-04 -1.621820e-04
## ASV0801      1.401931e-04  1.470072e-04  1.541574e-04  1.616607e-04
## ASV1611     -5.378981e-04 -5.631668e-04 -5.896060e-04 -6.172685e-04
## ASV0227     -1.948837e-04 -2.043626e-04 -2.143104e-04 -2.247507e-04
## ASV0833      2.093746e-04  2.195470e-04  2.302213e-04  2.414228e-04
## ASV0718      5.010020e-04  5.243944e-04  5.488573e-04  5.744376e-04
## ASV1139      1.839872e-04  1.921294e-04  2.006017e-04  2.094144e-04
## ASV0766     -1.368858e-04 -1.431423e-04 -1.496720e-04 -1.564859e-04
## ASV2091      6.731919e-04  7.038405e-04  7.358184e-04  7.691770e-04
## ASV1238     -4.294237e-05 -4.456768e-05 -4.623178e-05 -4.793307e-05
## ASV9193     -6.007107e-05 -6.319172e-05 -6.648441e-05 -6.995934e-05
## ASV0290     -5.587504e-05 -5.870295e-05 -6.168023e-05 -6.481518e-05
## ASV0231      5.316791e-04  5.563339e-04  5.821011e-04  6.090281e-04
## ASV0185      9.357005e-05  9.903482e-05  1.048530e-04  1.110497e-04
## ASV2330      1.536892e-04  1.607114e-04  1.680407e-04  1.756890e-04
## ASV3119     -1.738785e-04 -1.824423e-04 -1.914397e-04 -2.008936e-04
## ASV2368     -2.419107e-04 -2.534180e-04 -2.654720e-04 -2.780987e-04
## ASV0122     -1.914456e-04 -2.001028e-04 -2.091301e-04 -2.185414e-04
## ASV1044      3.318554e-04  3.478399e-04  3.646017e-04  3.821792e-04
## ASV0160     -4.723980e-04 -4.936206e-04 -5.157361e-04 -5.387765e-04
## ASV0326      3.051362e-04  3.193921e-04  3.343010e-04  3.498916e-04
## ASV1388      5.347128e-04  5.595682e-04  5.855503e-04  6.127074e-04
## ASV0792      6.064538e-04  6.343784e-04  6.635437e-04  6.940007e-04
## ASV0036     -3.821760e-04 -4.002123e-04 -4.190917e-04 -4.388528e-04
## ASV2125      6.252239e-04  6.542716e-04  6.846347e-04  7.163696e-04
## ASV1075      1.191875e-04  1.248808e-04  1.308468e-04  1.370987e-04
## ASV0390      1.165076e-04  1.223028e-04  1.283970e-04  1.348064e-04
## ASV3790     -5.019054e-04 -5.254496e-04 -5.500811e-04 -5.758485e-04
## ASV1535     -4.077398e-05 -4.282414e-05 -4.498217e-05 -4.725415e-05
## ASV0263      1.036674e-04  1.085180e-04  1.135914e-04  1.188974e-04
## ASV0675      8.237012e-04  8.627895e-04  9.037253e-04  9.465953e-04
## ASV3348      7.886404e-05  8.271612e-05  8.676066e-05  9.100763e-05
## ASV0058     -7.886568e-04 -8.251911e-04 -8.633694e-04 -9.032611e-04
## ASV4142      1.978096e-04  2.069487e-04  2.164960e-04  2.264685e-04
## ASV0059     -6.801920e-04 -7.116499e-04 -7.445183e-04 -7.788564e-04
## ASV0013     -1.418808e-03 -1.484704e-03 -1.553583e-03 -1.625572e-03
## ASV0033     -4.160400e-04 -4.357053e-04 -4.562928e-04 -4.778450e-04
## ASV4354     -1.819207e-04 -1.902235e-04 -1.988888e-04 -2.079312e-04
## ASV0022     -4.390166e-04 -4.597375e-04 -4.814272e-04 -5.041300e-04
## ASV0134     -1.086871e-04 -1.139843e-04 -1.195444e-04 -1.253807e-04
## ASV0415     -9.265672e-05 -9.652076e-05 -1.005190e-04 -1.046535e-04
## ASV10103    -3.073743e-04 -3.217985e-04 -3.368893e-04 -3.526765e-04
## ASV1613      4.981330e-04  5.210528e-04  5.449892e-04  5.699839e-04
## ASV0135     -2.748066e-05 -2.820515e-05 -2.890997e-05 -2.958931e-05
## ASV0469     -6.215901e-04 -6.501214e-04 -6.799124e-04 -7.110141e-04
## ASV0471      3.942035e-04  4.126294e-04  4.318997e-04  4.520516e-04
## ASV0451     -1.073418e-04 -1.126023e-04 -1.181270e-04 -1.239295e-04
## ASV0747      1.527713e-04  1.601920e-04  1.679789e-04  1.761505e-04
## ASV1314     -2.340949e-04 -2.453779e-04 -2.572106e-04 -2.696204e-04
## ASV0425     -7.063068e-04 -7.384164e-04 -7.719137e-04 -8.068521e-04
## ASV0559     -4.018838e-04 -4.201322e-04 -4.391684e-04 -4.590226e-04
## ASV0148     -4.359208e-04 -4.556592e-04 -4.762427e-04 -4.977032e-04
## ASV0129     -2.170823e-04 -2.265802e-04 -2.364526e-04 -2.467103e-04
## ASV1072      2.117266e-04  2.212593e-04  2.311949e-04  2.415480e-04
## ASV2390      1.509866e-04  1.577873e-04  1.648755e-04  1.722616e-04
## ASV0548      4.541380e-04  4.754195e-04  4.976820e-04  5.209693e-04
## ASV0168     -6.851995e-04 -7.167600e-04 -7.497241e-04 -7.841499e-04
## ASV0066     -5.078384e-04 -5.313380e-04 -5.558926e-04 -5.815468e-04
## ASV0468     -1.874449e-04 -1.961787e-04 -2.053104e-04 -2.148573e-04
## ASV0172     -1.074338e-04 -1.118517e-04 -1.164158e-04 -1.211270e-04
## ASV0236     -2.652272e-04 -2.767658e-04 -2.887531e-04 -3.012015e-04
## ASV0250      1.192923e-05  1.338959e-05  1.500185e-05  1.678061e-05
## ASV0338     -3.815954e-05 -3.943624e-05 -4.072497e-05 -4.202211e-05
## ASV0450     -2.408810e-06 -2.511669e-06 -2.618279e-06 -2.728710e-06
## ASV0377      5.575462e-04  5.834840e-04  6.105997e-04  6.389441e-04
## ASV1022      1.551070e-04  1.623684e-04  1.699640e-04  1.779088e-04
## ASV6174     -3.842796e-05 -4.016555e-05 -4.197776e-05 -4.386746e-05
## ASV0786      6.265774e-05  6.543242e-05  6.832023e-05  7.132490e-05
## ASV0053     -6.706648e-04 -7.019354e-04 -7.346327e-04 -7.688187e-04
## ASV0697     -1.948532e-04 -2.035958e-04 -2.127054e-04 -2.221952e-04
## ASV0785      4.993471e-04  5.226021e-04  5.469153e-04  5.723327e-04
## ASV1967     -3.306185e-04 -3.456187e-04 -3.612656e-04 -3.775838e-04
## ASV0385     -1.546630e-04 -1.615582e-04 -1.687387e-04 -1.762141e-04
## ASV0295      5.188325e-07  1.023006e-06  1.595615e-06  2.243918e-06
## ASV0072     -5.363684e-04 -5.608092e-04 -5.863114e-04 -6.129161e-04
## ASV0157     -2.231170e-04 -2.330538e-04 -2.433995e-04 -2.541678e-04
## ASV0501      2.434366e-04  2.551203e-04  2.673687e-04  2.802091e-04
## ASV10729    -4.083627e-04 -4.275133e-04 -4.475478e-04 -4.685054e-04
## ASV1470      1.945911e-04  2.034994e-04  2.127985e-04  2.225040e-04
## ASV0050     -1.340160e-03 -1.402134e-03 -1.466888e-03 -1.534537e-03
## ASV0411     -3.507093e-05 -3.647848e-05 -3.792872e-05 -3.942149e-05
## ASV0549      2.535960e-04  2.657121e-04  2.784087e-04  2.917139e-04
## ASV0184      1.563436e-04  1.636139e-04  1.712147e-04  1.791601e-04
## ASV0705      1.880756e-04  1.969866e-04  2.063170e-04  2.160861e-04
## ASV1715      4.752049e-04  4.974127e-04  5.206386e-04  5.449275e-04
## ASV0603      5.634918e-05  5.905194e-05  6.188534e-05  6.485580e-05
## ASV0826      1.596202e-04  1.668592e-04  1.744095e-04  1.822827e-04
## ASV0034     -6.060151e-04 -6.338482e-04 -6.629108e-04 -6.932526e-04
## ASV0838      1.277789e-04  1.336715e-04  1.398263e-04  1.462539e-04
## ASV0614     -3.443344e-04 -3.601983e-04 -3.767681e-04 -3.940730e-04
## ASV0014     -1.299009e-03 -1.359130e-03 -1.421951e-03 -1.487588e-03
## ASV0585     -8.154336e-05 -8.538805e-05 -8.941208e-05 -9.362363e-05
## ASV0016     -1.327921e-03 -1.389406e-03 -1.453655e-03 -1.520786e-03
## ASV5394     -3.364219e-04 -3.521744e-04 -3.686515e-04 -3.858853e-04
## ASV0666      2.863328e-04  2.995783e-04  3.134181e-04  3.278772e-04
## ASV2085      1.136272e-04  1.183567e-04  1.232491e-04  1.283067e-04
## ASV0003     -1.214775e-03 -1.270910e-03 -1.329558e-03 -1.390826e-03
## ASV0346     -2.391882e-05 -2.446268e-05 -2.497818e-05 -2.545921e-05
## ASV0267     -1.927853e-04 -2.014086e-04 -2.103904e-04 -2.197431e-04
## ASV0353      2.580064e-04  2.705897e-04  2.837991e-04  2.976667e-04
## ASV2419      3.431363e-04  3.589258e-04  3.754161e-04  3.926362e-04
## ASV0447      1.617141e-04  1.698701e-04  1.784555e-04  1.874942e-04
## ASV0654      5.303794e-04  5.553323e-04  5.814440e-04  6.087670e-04
## ASV0151      8.199563e-05  8.620897e-05  9.065190e-05  9.533801e-05
## ASV0065     -4.902540e-04 -5.129706e-04 -5.367100e-04 -5.615153e-04
## ASV0527      3.547645e-04  3.712255e-04  3.884299e-04  4.064095e-04
## ASV4055     -1.323947e-04 -1.387442e-04 -1.454002e-04 -1.523777e-04
## ASV0166     -4.089355e-04 -4.275741e-04 -4.470231e-04 -4.673142e-04
## ASV0417     -3.452177e-04 -3.611104e-04 -3.777093e-04 -3.950436e-04
## ASV0078     -2.771055e-04 -2.897201e-04 -3.028809e-04 -3.166091e-04
## ASV0322     -3.371952e-04 -3.525414e-04 -3.685520e-04 -3.852528e-04
## ASV0156     -4.375506e-04 -4.576402e-04 -4.786176e-04 -5.005190e-04
## ASV0648     -3.944141e-04 -4.129939e-04 -4.324391e-04 -4.527891e-04
## ASV0407      3.022055e-05  3.178723e-05  3.344039e-05  3.518522e-05
## ASV2030     -8.460137e-05 -8.831297e-05 -9.217329e-05 -9.618705e-05
## ASV0300      2.306998e-04  2.418958e-04  2.536437e-04  2.659714e-04
## ASV1150     -3.010290e-05 -3.133964e-05 -3.261689e-05 -3.393490e-05
## ASV0958      2.408765e-04  2.525542e-04  2.648071e-04  2.776645e-04
## ASV0216     -4.163444e-04 -4.352609e-04 -4.549948e-04 -4.755776e-04
## ASV0446      5.773649e-04  6.048964e-04  6.337406e-04  6.639599e-04
## ASV0367     -1.982998e-04 -2.074803e-04 -2.170737e-04 -2.270974e-04
## ASV0200     -3.693712e-04 -3.865807e-04 -4.045746e-04 -4.233870e-04
## ASV0334     -1.917530e-04 -1.999757e-04 -2.085068e-04 -2.173534e-04
## ASV1311      2.607603e-04  2.727750e-04  2.853242e-04  2.984301e-04
## ASV0458      2.816538e-04  2.946826e-04  3.082969e-04  3.225213e-04
## ASV1371      8.520663e-06  8.943190e-06  9.387427e-06  9.854554e-06
## ASV0418      3.437641e-04  3.597771e-04  3.765195e-04  3.940231e-04
## ASV0004      4.082124e-04  4.271737e-04  4.469933e-04  4.677078e-04
## ASV1943      2.984936e-04  3.121753e-04  3.264603e-04  3.413731e-04
## ASV1495     -7.290419e-05 -7.667255e-05 -8.064769e-05 -8.484191e-05
## ASV0901     -4.645528e-04 -4.865130e-04 -5.095036e-04 -5.335724e-04
## ASV0628      2.720237e-04  2.844748e-04  2.974718e-04  3.110364e-04
## ASV0400      1.089665e-04  1.139624e-04  1.191779e-04  1.246220e-04
## ASV0116     -3.576327e-04 -3.747097e-04 -3.926038e-04 -4.113540e-04
## ASV0788      2.951059e-04  3.088844e-04  3.232933e-04  3.383604e-04
## ASV0117      1.896604e-04  1.988224e-04  2.084326e-04  2.185134e-04
## ASV3137      5.201115e-05  5.439168e-05  5.687671e-05  5.947043e-05
## ASV0001      4.903121e-04  5.126202e-04  5.358942e-04  5.601716e-04
## ASV1651      3.270085e-04  3.418844e-04  3.574047e-04  3.735944e-04
## ASV1692      3.484149e-04  3.650329e-04  3.824442e-04  4.006865e-04
## ASV0660      2.005223e-04  2.094772e-04  2.188030e-04  2.285125e-04
## ASV0508      2.475238e-05  2.575147e-05  2.678220e-05  2.784473e-05
## ASV1660     -1.430112e-04 -1.499290e-04 -1.571855e-04 -1.647973e-04
## ASV0233      7.956517e-05  8.342162e-05  8.746817e-05  9.171447e-05
## ASV1343     -3.509847e-04 -3.674554e-04 -3.846876e-04 -4.027155e-04
## ASV0209      3.254627e-04  3.401991e-04  3.555671e-04  3.715906e-04
## ASV0193     -4.233242e-04 -4.426905e-04 -4.629059e-04 -4.840042e-04
## ASV0357     -2.497896e-05 -2.578800e-05 -2.660003e-05 -2.741194e-05
## ASV0198      9.042177e-05  9.467959e-05  9.913559e-05  1.037988e-04
## ASV0007      4.648034e-04  4.859500e-04  5.080122e-04  5.310253e-04
## ASV1772     -4.755275e-05 -4.973200e-05 -5.200679e-05 -5.438087e-05
## ASV0009      4.384836e-04  4.584006e-04  4.791771e-04  5.008458e-04
## ASV0006      1.765326e-04  1.842286e-04  1.922257e-04  2.005324e-04
## ASV0011     -4.904111e-04 -5.135138e-04 -5.376927e-04 -5.629970e-04
## ASV0015      3.431166e-04  3.590750e-04  3.757574e-04  3.931951e-04
## ASV0017      3.633230e-04  3.801936e-04  3.978271e-04  4.162562e-04
## ASV0235     -2.863901e-04 -2.998663e-04 -3.139686e-04 -3.287251e-04
## ASV0382      5.094623e-05  5.382990e-05  5.689207e-05  6.014476e-05
## ASV2357      4.355670e-04  4.559647e-04  4.773016e-04  4.996195e-04
## ASV0567     -3.163382e-04 -3.309021e-04 -3.461137e-04 -3.619999e-04
## ASV0165      3.461677e-04  3.622718e-04  3.791073e-04  3.967059e-04
## ASV0005      6.975473e-04  7.296976e-04  7.632791e-04  7.983511e-04
## ASV0384     -3.308156e-05 -3.431263e-05 -3.557004e-05 -3.685208e-05
## ASV0002      1.491947e-04  1.563867e-04  1.639291e-04  1.718394e-04
## ASV3017      4.068122e-04  4.254428e-04  4.448917e-04  4.651915e-04
## ASV0091      1.562551e-04  1.636719e-04  1.714393e-04  1.795737e-04
## ASV0186     -4.194940e-04 -4.391573e-04 -4.597273e-04 -4.812442e-04
## ASV0370      4.265252e-05  4.472125e-05  4.689182e-05  4.916934e-05
## ASV0018      7.265427e-04  7.600905e-04  7.951376e-04  8.317464e-04
## ASV1377      6.343960e-04  6.636215e-04  6.941473e-04  7.260271e-04
## ASV0019      7.274795e-04  7.610770e-04  7.961768e-04  8.328415e-04
## ASV0023      5.065862e-05  5.250287e-05  5.438292e-05  5.629587e-05
## ASV2194      2.369699e-04  2.481974e-04  2.599543e-04  2.722653e-04
## ASV1155     -2.686424e-05 -2.788028e-05 -2.891970e-05 -2.998129e-05
## ASV0510     -2.673957e-04 -2.792439e-04 -2.915745e-04 -3.044033e-04
## ASV2371     -2.622875e-04 -2.740913e-04 -2.863951e-04 -2.992173e-04
## ASV0024      1.575092e-05  1.596642e-05  1.614331e-05  1.627545e-05
## ASV2452      3.419459e-04  3.574972e-04  3.737206e-04  3.906417e-04
## ASV2332      1.751703e-05  1.883135e-05  2.025091e-05  2.178431e-05
## ASV2591      1.591307e-05  1.715541e-05  1.849971e-05  1.995439e-05
## ASV0521      4.664579e-04  4.885901e-04  5.117682e-04  5.360412e-04
## ASV5542      1.445604e-04  1.515446e-04  1.588692e-04  1.665509e-04
## ASV0336     -2.189257e-04 -2.290729e-04 -2.396774e-04 -2.507587e-04
## ASV10102     3.238039e-04  3.390656e-04  3.550384e-04  3.717548e-04
## ASV16823    -2.540323e-04 -2.653949e-04 -2.772324e-04 -2.895618e-04
## ASV3104      2.540080e-04  2.653683e-04  2.772034e-04  2.895302e-04
## ASV0781      1.228509e-04  1.285069e-04  1.344138e-04  1.405819e-04
## ASV10899     1.186857e-04  1.246781e-04  1.309862e-04  1.376275e-04
## ASV11222    -2.539918e-04 -2.653508e-04 -2.771844e-04 -2.895095e-04
## ASV11327    -2.539674e-04 -2.653242e-04 -2.771554e-04 -2.894779e-04
## ASV12458    -2.539431e-04 -2.652976e-04 -2.771264e-04 -2.894462e-04
## ASV1636     -2.076452e-04 -2.169038e-04 -2.265461e-04 -2.365854e-04
## ASV1890     -2.530945e-04 -2.645062e-04 -2.764038e-04 -2.888057e-04
## ASV2898      5.478126e-04  5.730177e-04  5.993408e-04  6.268279e-04
## ASV8328     -4.202207e-05 -4.341074e-05 -4.481047e-05 -4.621706e-05
## ASV0709     -4.479406e-04 -4.686140e-04 -4.902099e-04 -5.127666e-04
## ASV0856      7.175195e-05  7.529383e-05  7.901539e-05  8.292612e-05
## ASV0909     -1.888488e-04 -1.969683e-04 -2.053943e-04 -2.141341e-04
## ASV0937     -3.496301e-04 -3.659916e-04 -3.831064e-04 -4.010082e-04
## ASV11390    -2.538911e-04 -2.652409e-04 -2.770646e-04 -2.893789e-04
## ASV11966     1.303293e-04  1.367241e-04  1.434397e-04  1.504927e-04
## ASV12990     6.930451e-05  7.258773e-05  7.602465e-05  7.962222e-05
## ASV14797     2.629994e-04  2.749817e-04  2.874841e-04  3.005268e-04
## ASV14904    -2.538845e-04 -2.652338e-04 -2.770569e-04 -2.893706e-04
## ASV15304     6.928938e-05  7.290009e-05  7.671010e-05  8.073117e-05
## ASV16696    -2.538646e-04 -2.652121e-04 -2.770333e-04 -2.893450e-04
## ASV1690      1.326960e-04  1.393099e-04  1.462642e-04  1.535768e-04
## ASV2029      7.033908e-04  7.359149e-04  7.698973e-04  8.053994e-04
## ASV2834      3.770832e-04  3.946938e-04  4.131110e-04  4.323704e-04
## ASV4003      1.088733e-04  1.144860e-04  1.204041e-04  1.266455e-04
## ASV4064      2.640367e-04  2.765333e-04  2.896167e-04  3.033140e-04
## ASV4294      9.187788e-05  9.656336e-05  1.014998e-04  1.067014e-04
## ASV4609     -1.028944e-05 -1.063308e-05 -1.098048e-05 -1.133079e-05
## ASV6283     -2.538617e-04 -2.652092e-04 -2.770305e-04 -2.893423e-04
## ASV6491     -2.538374e-04 -2.651827e-04 -2.770015e-04 -2.893107e-04
## ASV7453      1.013290e-04  1.064834e-04  1.119123e-04  1.176313e-04
## ASV7959      2.068130e-05  2.207603e-05  2.357358e-05  2.518192e-05
## ASV8219      2.538206e-04  2.651645e-04  2.769819e-04  2.892894e-04
## ASV8547     -2.537963e-04 -2.651380e-04 -2.769529e-04 -2.892578e-04
## ASV9319      1.724228e-04  1.806395e-04  1.892470e-04  1.982637e-04
## ASV9382     -2.537815e-04 -2.651219e-04 -2.769354e-04 -2.892388e-04
## ASV11516    -2.537572e-04 -2.650954e-04 -2.769065e-04 -2.892073e-04
## ASV14377    -2.537329e-04 -2.650689e-04 -2.768776e-04 -2.891757e-04
## ASV1867      3.731019e-04  3.906870e-04  4.090917e-04  4.283533e-04
## ASV1895     -8.646151e-05 -9.028341e-05 -9.426082e-05 -9.839892e-05
## ASV3168      1.586780e-04  1.659508e-04  1.735423e-04  1.814649e-04
## ASV4449      3.163025e-04  3.306386e-04  3.455921e-04  3.611867e-04
## ASV6596      1.827689e-04  1.917365e-04  2.011548e-04  2.110474e-04
## ASV7492     -9.396971e-05 -9.780819e-05 -1.017725e-04 -1.058638e-04
## ASV9854     -1.304378e-04 -1.361730e-04 -1.421391e-04 -1.483434e-04
## ASV6296      2.536818e-04  2.650133e-04  2.768171e-04  2.891099e-04
## ASV4201      8.463184e-05  8.919957e-05  9.403283e-05  9.914833e-05
## ASV0552      6.243474e-04  6.538168e-04  6.846643e-04  7.169528e-04
## ASV3671     -5.161841e-05 -5.362505e-05 -5.568743e-05 -5.780491e-05
## ASV3529     -5.493561e-05 -5.697316e-05 -5.905654e-05 -6.118367e-05
## ASV1060      1.572805e-04  1.647342e-04  1.725397e-04  1.807135e-04
## ASV0239     -3.543347e-04 -3.702744e-04 -3.868869e-04 -4.041968e-04
## ASV5711     -3.261413e-04 -3.409114e-04 -3.563163e-04 -3.723803e-04
## ASV4152     -4.314637e-04 -4.513092e-04 -4.720360e-04 -4.936804e-04
## ASV1461      3.841606e-04  4.015288e-04  4.196384e-04  4.385168e-04
## ASV2877      3.137351e-04  3.282149e-04  3.433405e-04  3.591388e-04
## ASV0012      2.359483e-04  2.472440e-04  2.590826e-04  2.714905e-04
## ASV9823      8.496133e-05  8.872858e-05  9.264924e-05  9.672825e-05
## ASV0008      2.577045e-04  2.699700e-04  2.828187e-04  2.962781e-04
## ASV7832     -2.654085e-04 -2.775226e-04 -2.901666e-04 -3.033616e-04
## ASV1915      2.130632e-05  2.252421e-05  2.381757e-05  2.519139e-05
## ASV0055      1.828344e-04  1.913208e-04  2.001903e-04  2.094595e-04
## ASV0032      4.419637e-04  4.621832e-04  4.832893e-04  5.053173e-04
## ASV2977     -3.633353e-04 -3.800393e-04 -3.974842e-04 -4.157006e-04
## ASV0466      3.678775e-04  3.845668e-04  4.019747e-04  4.201288e-04
## ASV3866      3.883275e-04  4.065799e-04  4.256787e-04  4.456618e-04
## ASV0040      5.165238e-04  5.409661e-04  5.665573e-04  5.933506e-04
## ASV0496     -2.825392e-05 -3.000584e-05 -3.187832e-05 -3.388037e-05
## ASV0052      6.281708e-04  6.572025e-04  6.875344e-04  7.192207e-04
## ASV3828     -3.866729e-04 -4.043974e-04 -4.229039e-04 -4.422244e-04
## ASV1930      2.413993e-04  2.526719e-04  2.644594e-04  2.767839e-04
## ASV2126      3.923820e-04  4.105773e-04  4.295927e-04  4.494631e-04
## ASV0793      2.364387e-04  2.479238e-04  2.599758e-04  2.726234e-04
## ASV0299     -1.640107e-04 -1.711770e-04 -1.786262e-04 -1.863667e-04
## ASV0208      3.663526e-04  3.838072e-04  4.020934e-04  4.212507e-04
## ASV0511     -1.987812e-04 -2.074564e-04 -2.164714e-04 -2.258360e-04
## ASV1123     -2.622370e-04 -2.739804e-04 -2.862147e-04 -2.989571e-04
## ASV0099     -1.442525e-04 -1.508551e-04 -1.577463e-04 -1.649375e-04
## ASV0752     -2.996304e-05 -3.158409e-05 -3.329909e-05 -3.511386e-05
## ASV0883      4.016616e-06  4.341639e-06  4.693991e-06  5.075965e-06
## ASV0683      3.272345e-04  3.428014e-04  3.591073e-04  3.761869e-04
## ASV4117     -3.892408e-04 -4.071139e-04 -4.257783e-04 -4.452665e-04
## ASV2172      1.454742e-04  1.522823e-04  1.594029e-04  1.668499e-04
## ASV0330     -2.642224e-04 -2.765996e-04 -2.895465e-04 -3.030884e-04
## ASV0728      2.510778e-04  2.630754e-04  2.756464e-04  2.888181e-04
## ASV0499      4.938048e-04  5.172864e-04  5.418827e-04  5.676465e-04
## ASV0120     -5.481296e-04 -5.736269e-04 -6.002809e-04 -6.281413e-04
## ASV1446      4.515671e-05  4.691201e-05  4.871514e-05  5.056529e-05
## ASV17171    -3.697503e-04 -3.867775e-04 -4.045632e-04 -4.231390e-04
## ASV0533      1.049116e-04  1.099574e-04  1.152479e-04  1.207954e-04
## ASV2495     -1.498851e-04 -1.569703e-04 -1.643892e-04 -1.721576e-04
## ASV5582      1.305021e-04  1.362790e-04  1.422905e-04  1.485441e-04
## ASV1488      1.191043e-04  1.248036e-04  1.307764e-04  1.370357e-04
## ASV0682      3.437974e-04  3.601391e-04  3.772559e-04  3.951843e-04
## ASV0068     -2.086727e-05 -2.218308e-05 -2.359066e-05 -2.509686e-05
## ASV1987     -1.864186e-04 -1.955343e-04 -2.051050e-04 -2.151541e-04
## ASV0035      6.459416e-05  6.704603e-05  6.955630e-05  7.212241e-05
## ASV7192     -2.489575e-04 -2.601885e-04 -2.718975e-04 -2.841024e-04
## ASV0873      3.650820e-05  3.789477e-05  3.931626e-05  4.077173e-05
## ASV4749      2.066303e-05  2.109128e-05  2.148869e-05  2.184921e-05
## ASV2174      2.366221e-04  2.472121e-04  2.582445e-04  2.697348e-04
## ASV1476     -2.056449e-04 -2.152445e-04 -2.252844e-04 -2.357842e-04
## ASV0740     -5.002936e-04 -5.240233e-04 -5.488735e-04 -5.748966e-04
## ASV0170      1.064172e-04  1.113730e-04  1.165545e-04  1.219719e-04
## ASV2466     -4.544920e-04 -4.755844e-04 -4.976314e-04 -5.206742e-04
## ASV1709      3.527819e-04  3.690390e-04  3.860207e-04  4.037572e-04
## ASV6170     -3.244277e-04 -3.396717e-04 -3.556223e-04 -3.723112e-04
## ASV3673      3.713600e-04  3.888258e-04  4.071028e-04  4.262275e-04
## ASV1745      2.852465e-05  2.987968e-05  3.129870e-05  3.278467e-05
##                                                                    
## (Intercept) -4.548311e-06 -5.194255e-06 -5.930070e-06 -6.767897e-06
## ASV1236      3.189516e-04  3.333812e-04  3.484283e-04  3.641162e-04
## ASV0421     -5.675405e-04 -5.933507e-04 -6.202779e-04 -6.483654e-04
## ASV0691     -4.931350e-04 -5.150552e-04 -5.378777e-04 -5.616330e-04
## ASV0899     -6.372417e-06 -6.330410e-06 -6.256802e-06 -6.147768e-06
## ASV1004      6.450982e-04  6.744592e-04  7.050927e-04  7.370478e-04
## ASV1041     -4.367154e-04 -4.566133e-04 -4.773748e-04 -4.990334e-04
## ASV1058      5.996585e-04  6.269590e-04  6.554440e-04  6.851597e-04
## ASV12542     1.836197e-04  1.917395e-04  2.001895e-04  2.089806e-04
## ASV1294      6.977849e-04  7.297906e-04  7.632068e-04  7.980907e-04
## ASV13113     2.517710e-04  2.637745e-04  2.763509e-04  2.895277e-04
## ASV1318      6.079329e-04  6.356369e-04  6.645449e-04  6.947038e-04
## ASV2269     -1.811374e-04 -1.894114e-04 -1.980463e-04 -2.070560e-04
## ASV2542      3.925607e-04  4.110812e-04  4.304668e-04  4.507572e-04
## ASV2660     -3.501500e-04 -3.659468e-04 -3.824148e-04 -3.995789e-04
## ASV2737     -1.868224e-05 -1.970561e-05 -2.078880e-05 -2.193548e-05
## ASV2840      4.657832e-04  4.866948e-04  5.084856e-04  5.311869e-04
## ASV3053      2.512048e-05  2.619405e-05  2.730825e-05  2.846421e-05
## ASV3077      1.451057e-04  1.516500e-04  1.584730e-04  1.655850e-04
## ASV3134      5.068422e-04  5.309046e-04  5.561061e-04  5.825002e-04
## ASV3140      2.222637e-04  2.327232e-04  2.436679e-04  2.551196e-04
## ASV3579      9.034941e-05  9.492190e-05  9.973711e-05  1.048088e-04
## ASV6119     -1.810959e-04 -1.893661e-04 -1.979967e-04 -2.070019e-04
## ASV7557     -1.810745e-04 -1.893427e-04 -1.979712e-04 -2.069740e-04
## ASV8422      1.002861e-04  1.047238e-04  1.093427e-04  1.141491e-04
## ASV1086     -5.034194e-05 -5.255952e-05 -5.486695e-05 -5.726719e-05
## ASV1310      3.453272e-04  3.611939e-04  3.777622e-04  3.950604e-04
## ASV15750    -8.564619e-05 -8.950517e-05 -9.352703e-05 -9.771759e-05
## ASV16905    -1.810664e-04 -1.893338e-04 -1.979613e-04 -2.069632e-04
## ASV2033      3.430041e-04  3.592679e-04  3.762991e-04  3.941333e-04
## ASV2089      1.240548e-04  1.297422e-04  1.356793e-04  1.418761e-04
## ASV2127      4.958579e-04  5.185085e-04  5.421488e-04  5.668180e-04
## ASV2725      5.602409e-04  5.854677e-04  6.117628e-04  6.391654e-04
## ASV2804     -1.810613e-04 -1.893282e-04 -1.979553e-04 -2.069567e-04
## ASV3075      3.563550e-04  3.727548e-04  3.898844e-04  4.077739e-04
## ASV3327      3.348019e-04  3.505891e-04  3.671136e-04  3.844089e-04
## ASV3342      3.641657e-04  3.811806e-04  3.989746e-04  4.175821e-04
## ASV3532     -3.285198e-04 -3.438493e-04 -3.598792e-04 -3.766401e-04
## ASV3600      4.163847e-04  4.357528e-04  4.560010e-04  4.771672e-04
## ASV4013      3.493906e-04  3.654029e-04  3.821199e-04  3.995700e-04
## ASV4136      3.460084e-04  3.616686e-04  3.779998e-04  3.950272e-04
## ASV4195      1.810307e-04  1.892949e-04  1.979189e-04  2.069169e-04
## ASV4407     -1.810093e-04 -1.892715e-04 -1.978934e-04 -2.068890e-04
## ASV4717      9.772685e-06  1.006082e-05  1.034756e-05  1.063165e-05
## ASV6794      1.864700e-04  1.947419e-04  2.033535e-04  2.123164e-04
## ASV8324     -1.810034e-04 -1.892649e-04 -1.978861e-04 -2.068810e-04
## ASV8981     -4.790921e-05 -4.988076e-05 -5.191716e-05 -5.401883e-05
## ASV9859      1.405255e-04  1.474370e-04  1.546983e-04  1.623279e-04
## ASV0936     -2.845406e-04 -2.975721e-04 -3.111767e-04 -3.253773e-04
## ASV12683    -2.953904e-05 -3.101732e-05 -3.257156e-05 -3.420572e-05
## ASV1293      4.195259e-04  4.385875e-04  4.584722e-04  4.792115e-04
## ASV13055    -4.390870e-05 -4.583744e-05 -4.784252e-05 -4.992614e-05
## ASV17063    -1.809669e-04 -1.892251e-04 -1.978428e-04 -2.068339e-04
## ASV2228      1.809455e-04  1.892018e-04  1.978173e-04  2.068060e-04
## ASV2769     -3.281169e-05 -3.410637e-05 -3.543803e-05 -3.680623e-05
## ASV2803      8.592454e-05  8.969016e-05  9.360617e-05  9.767730e-05
## ASV2896      2.284235e-04  2.390569e-04  2.501754e-04  2.618005e-04
## ASV3062      7.078026e-05  7.437239e-05  7.815610e-05  8.214234e-05
## ASV3107      2.751446e-04  2.879569e-04  3.013528e-04  3.153577e-04
## ASV3265      5.455447e-04  5.703050e-04  5.961320e-04  6.230665e-04
## ASV3666     -1.253124e-05 -1.315341e-05 -1.380732e-05 -1.449462e-05
## ASV4497      1.293060e-04  1.351873e-04  1.413236e-04  1.477248e-04
## ASV6914     -6.366185e-05 -6.665016e-05 -6.977608e-05 -7.304566e-05
## ASV0576     -6.429685e-04 -6.717053e-04 -7.016395e-04 -7.328133e-04
## ASV0673      1.685273e-04  1.766491e-04  1.851648e-04  1.940933e-04
## ASV0772      1.955435e-04  2.045582e-04  2.139754e-04  2.238118e-04
## ASV0862     -1.558959e-04 -1.627220e-04 -1.698187e-04 -1.771941e-04
## ASV0898      1.625976e-04  1.704571e-04  1.787004e-04  1.873464e-04
## ASV0910      3.509415e-04  3.676743e-04  3.852049e-04  4.035713e-04
## ASV0964     -2.330305e-04 -2.435121e-04 -2.544364e-04 -2.658196e-04
## ASV10059     1.642951e-04  1.721771e-04  1.804400e-04  1.891025e-04
## ASV10263    -1.810624e-04 -1.893297e-04 -1.979572e-04 -2.069590e-04
## ASV1088      1.865134e-04  1.954339e-04  2.047832e-04  2.145824e-04
## ASV1101      3.151310e-04  3.296539e-04  3.448223e-04  3.606629e-04
## ASV1183      2.018130e-04  2.112082e-04  2.210302e-04  2.312971e-04
## ASV11956     7.801277e-05  8.136746e-05  8.485000e-05  8.846379e-05
## ASV12774    -2.760310e-05 -2.897069e-05 -3.040760e-05 -3.191741e-05
## ASV1321      8.153544e-05  8.572496e-05  9.014187e-05  9.479943e-05
## ASV13793    -1.810375e-04 -1.893025e-04 -1.979274e-04 -2.069265e-04
## ASV14482    -1.692483e-05 -1.782323e-05 -1.877171e-05 -1.977315e-05
## ASV15483     1.281863e-04  1.341972e-04  1.404860e-04  1.470652e-04
## ASV2062      8.016991e-04  8.386811e-04  8.773132e-04  9.176639e-04
## ASV2132      3.659439e-04  3.831235e-04  4.010983e-04  4.199040e-04
## ASV2413      5.174764e-04  5.410543e-04  5.656577e-04  5.913269e-04
## ASV2490      3.399735e-04  3.552711e-04  3.712157e-04  3.878306e-04
## ASV2594      1.874420e-04  1.961034e-04  2.051543e-04  2.146114e-04
## ASV2822     -1.810731e-04 -1.893415e-04 -1.979702e-04 -2.069733e-04
## ASV2863      3.157618e-04  3.300726e-04  3.449982e-04  3.605620e-04
## ASV2910      4.116718e-04  4.302906e-04  4.497060e-04  4.699481e-04
## ASV2980      1.491705e-04  1.559380e-04  1.629962e-04  1.703558e-04
## ASV3307      1.810375e-04  1.893025e-04  1.979276e-04  2.069268e-04
## ASV3474      2.861984e-04  2.998807e-04  3.142187e-04  3.292440e-04
## ASV3502      5.923483e-04  6.197410e-04  6.483629e-04  6.782655e-04
## ASV4236      2.991517e-04  3.126174e-04  3.266527e-04  3.412787e-04
## ASV4842     -9.899851e-05 -1.035699e-04 -1.083447e-04 -1.133312e-04
## ASV4894     -1.810625e-04 -1.893300e-04 -1.979577e-04 -2.069598e-04
## ASV5290      2.237497e-04  2.341082e-04  2.449323e-04  2.562417e-04
## ASV5501      4.188504e-05  4.380731e-05  4.581522e-05  4.791240e-05
## ASV5795      1.512714e-04  1.584217e-04  1.659075e-04  1.737444e-04
## ASV5987     -1.810712e-04 -1.893396e-04 -1.979683e-04 -2.069714e-04
## ASV6267     -1.810499e-04 -1.893162e-04 -1.979427e-04 -2.069435e-04
## ASV6862      3.487756e-04  3.643359e-04  3.805422e-04  3.974171e-04
## ASV7145      6.388855e-05  6.667401e-05  6.956994e-05  7.257981e-05
## ASV7673     -1.810440e-04 -1.893098e-04 -1.979356e-04 -2.069357e-04
## ASV7789      6.717197e-05  7.062745e-05  7.427142e-05  7.811503e-05
## ASV7809     -2.174472e-05 -2.253931e-05 -2.334939e-05 -2.417369e-05
## ASV8002     -1.810283e-04 -1.892927e-04 -1.979171e-04 -2.069156e-04
## ASV8205      1.058107e-04  1.107109e-04  1.158325e-04  1.211849e-04
## ASV9155     -1.362641e-04 -1.424589e-04 -1.489210e-04 -1.556605e-04
## ASV9221     -1.996678e-05 -2.064866e-05 -2.133783e-05 -2.203234e-05
## ASV9311     -1.809998e-04 -1.892616e-04 -1.978832e-04 -2.068787e-04
## ASV9557     -1.809784e-04 -1.892382e-04 -1.978577e-04 -2.068508e-04
## ASV9936     -1.809570e-04 -1.892149e-04 -1.978321e-04 -2.068228e-04
## ASV1445      4.202610e-04  4.399306e-04  4.605048e-04  4.820240e-04
## ASV4232      3.558780e-04  3.727775e-04  3.904779e-04  4.090172e-04
## ASV6479     -3.429301e-07  3.516447e-08  4.673505e-07  9.593779e-07
## ASV0142     -9.160593e-04 -9.574483e-04 -1.000604e-03 -1.045592e-03
## ASV0378     -2.997270e-04 -3.130805e-04 -3.269851e-04 -3.414594e-04
## ASV1122      5.554742e-04  5.814925e-04  6.087087e-04  6.371762e-04
## ASV0123     -8.973229e-04 -9.378374e-04 -9.800783e-04 -1.024110e-03
## ASV2064      9.251436e-05  9.652309e-05  1.006871e-04  1.050108e-04
## ASV4459     -9.919465e-05 -1.036883e-04 -1.083743e-04 -1.132600e-04
## ASV0448      1.600475e-04  1.680272e-04  1.764186e-04  1.852441e-04
## ASV0397      4.147418e-04  4.340297e-04  4.541927e-04  4.752684e-04
## ASV0485      5.797146e-04  6.064022e-04  6.342762e-04  6.633858e-04
## ASV1566      4.858455e-04  5.084063e-04  5.319874e-04  5.566325e-04
## ASV1365      3.149329e-04  3.295957e-04  3.449255e-04  3.609512e-04
## ASV1065      6.448819e-04  6.748686e-04  7.062154e-04  7.389809e-04
## ASV0722     -1.315189e-05 -1.366585e-05 -1.419477e-05 -1.473863e-05
## ASV12660    -3.015815e-04 -3.151471e-04 -3.292864e-04 -3.440203e-04
## ASV0223     -1.193127e-05 -1.243709e-05 -1.296104e-05 -1.350339e-05
## ASV0229      2.888624e-04  3.024653e-04  3.167015e-04  3.315999e-04
## ASV0877     -1.092860e-04 -1.140557e-04 -1.190129e-04 -1.241630e-04
## ASV0983      5.914455e-04  6.185405e-04  6.468267e-04  6.763520e-04
## ASV0626     -1.927260e-04 -2.009730e-04 -2.095284e-04 -2.183995e-04
## ASV4146     -3.234515e-05 -3.378531e-05 -3.528474e-05 -3.684544e-05
## ASV4175     -3.631927e-04 -3.800455e-04 -3.976589e-04 -4.160653e-04
## ASV2082     -2.723429e-05 -2.878108e-05 -3.042554e-05 -3.217460e-05
## ASV2272      2.627969e-04  2.751468e-04  2.880700e-04  3.015923e-04
## ASV2245     -3.165374e-04 -3.313068e-04 -3.467503e-04 -3.628973e-04
## ASV0590     -1.939572e-04 -2.034533e-04 -2.134249e-04 -2.238965e-04
## ASV0217     -2.896087e-04 -3.017053e-04 -3.142242e-04 -3.271721e-04
## ASV0416      2.931553e-04  3.060749e-04  3.195152e-04  3.334927e-04
## ASV1056      3.524260e-04  3.693039e-04  3.869929e-04  4.055321e-04
## ASV7777     -3.135600e-04 -3.281303e-04 -3.433605e-04 -3.592790e-04
## ASV0455      6.370236e-05  6.682857e-05  7.011097e-05  7.355747e-05
## ASV0604      6.989847e-05  7.358909e-05  7.748770e-05  8.160691e-05
## ASV6100     -2.896770e-04 -3.031720e-04 -3.172816e-04 -3.320323e-04
## ASV11359    -3.238749e-04 -3.388341e-04 -3.544621e-04 -3.707867e-04
## ASV6604      2.306264e-04  2.415212e-04  2.529266e-04  2.648662e-04
## ASV5004     -1.900213e-04 -1.987845e-04 -2.079383e-04 -2.174988e-04
## ASV1483     -1.754226e-04 -1.835537e-04 -1.920510e-04 -2.009299e-04
## ASV9773     -3.710180e-04 -3.882687e-04 -4.063018e-04 -4.251510e-04
## ASV4059      3.619377e-05  3.814265e-05  4.020499e-05  4.238801e-05
## ASV1193      6.037778e-04  6.317716e-04  6.610275e-04  6.915991e-04
## ASV4610     -5.136871e-05 -5.322864e-05 -5.512530e-05 -5.705612e-05
## ASV0742     -2.237638e-04 -2.333885e-04 -2.433778e-04 -2.537408e-04
## ASV1502     -4.188684e-06 -4.620784e-06 -5.094340e-06 -5.613112e-06
## ASV0195     -6.745173e-05 -7.088987e-05 -7.451116e-05 -7.832585e-05
## ASV1213      1.902338e-04  1.986792e-04  2.074702e-04  2.166185e-04
## ASV1648     -2.744953e-04 -2.872207e-04 -3.005199e-04 -3.144173e-04
## ASV6984     -2.056315e-04 -2.152262e-04 -2.252592e-04 -2.357499e-04
## ASV0396     -1.520357e-04 -1.580509e-04 -1.642421e-04 -1.706081e-04
## ASV4297      3.090006e-04  3.229241e-04  3.374386e-04  3.525658e-04
## ASV2622      7.042063e-04  7.362139e-04  7.696057e-04  8.044352e-04
## ASV3512      1.097638e-04  1.152930e-04  1.211135e-04  1.272418e-04
## ASV2411      2.433752e-04  2.549836e-04  2.671458e-04  2.798881e-04
## ASV2291     -6.238306e-05 -6.555496e-05 -6.889661e-05 -7.241776e-05
## ASV0807      2.864769e-04  3.004781e-04  3.151773e-04  3.306102e-04
## ASV1292      1.588972e-04  1.661165e-04  1.736481e-04  1.815041e-04
## ASV1035      7.398296e-05  7.719557e-05  8.053399e-05  8.400198e-05
## ASV0070     -1.656244e-04 -1.726825e-04 -1.800002e-04 -1.875830e-04
## ASV0255      6.829611e-05  7.146096e-05  7.476776e-05  7.822235e-05
## ASV0057     -7.253125e-04 -7.577679e-04 -7.915777e-04 -8.267895e-04
## ASV0077     -1.047943e-04 -1.090949e-04 -1.135371e-04 -1.181221e-04
## ASV0625      7.229278e-04  7.556234e-04  7.897171e-04  8.252612e-04
## ASV2464      3.495193e-04  3.651295e-04  3.813902e-04  3.983243e-04
## ASV1315      6.334336e-04  6.634651e-04  6.949133e-04  7.278441e-04
## ASV2673      4.614067e-04  4.834068e-04  5.064567e-04  5.306066e-04
## ASV2161      1.901852e-04  1.992917e-04  2.088363e-04  2.188404e-04
## ASV0337     -3.030532e-04 -3.169860e-04 -3.315359e-04 -3.467281e-04
## ASV7680     -3.567646e-04 -3.733973e-04 -3.907883e-04 -4.089709e-04
## ASV0611      7.772852e-04  8.138742e-04  8.521660e-04  8.922384e-04
## ASV3118     -2.639754e-04 -2.763724e-04 -2.893430e-04 -3.029127e-04
## ASV1284      2.786293e-04  2.916960e-04  3.053659e-04  3.196658e-04
## ASV0889      2.116358e-04  2.213347e-04  2.314612e-04  2.420327e-04
## ASV4649     -2.213106e-04 -2.315775e-04 -2.423078e-04 -2.535210e-04
## ASV1108     -2.843115e-04 -2.979268e-04 -3.121967e-04 -3.271529e-04
## ASV0738     -4.020132e-05 -4.104300e-05 -4.182732e-05 -4.254306e-05
## ASV0473      4.366306e-05  4.571018e-05  4.785226e-05  5.009367e-05
## ASV0598     -3.194383e-04 -3.336439e-04 -3.484341e-04 -3.638287e-04
## ASV0429      5.120499e-04  5.355738e-04  5.601377e-04  5.857836e-04
## ASV1549      5.141657e-04  5.387563e-04  5.645268e-04  5.915341e-04
## ASV1203      3.871985e-04  4.050699e-04  4.237394e-04  4.432403e-04
## ASV4532      1.668893e-05  1.731457e-05  1.795574e-05  1.861208e-05
## ASV0274     -3.871336e-04 -4.044039e-04 -4.223905e-04 -4.411182e-04
## ASV0163     -5.525874e-04 -5.771559e-04 -6.027352e-04 -6.293594e-04
## ASV1298      2.245051e-04  2.344820e-04  2.448694e-04  2.556815e-04
## ASV9424     -4.734332e-04 -4.956160e-04 -5.188210e-04 -5.430937e-04
## ASV0412      7.279620e-04  7.614383e-04  7.963996e-04  8.329071e-04
## ASV0284      3.245889e-04  3.391375e-04  3.542963e-04  3.700874e-04
## ASV0620     -2.444958e-04 -2.562367e-04 -2.685444e-04 -2.814465e-04
## ASV0153     -5.079281e-04 -5.319647e-04 -5.571309e-04 -5.834791e-04
## ASV0498      5.734676e-05  6.078912e-05  6.445861e-05  6.837133e-05
## ASV0097      3.640753e-04  3.814031e-04  3.995551e-04  4.185705e-04
## ASV0104     -1.675594e-03 -1.753054e-03 -1.833987e-03 -1.918537e-03
## ASV1282      2.920738e-04  3.057514e-04  3.200582e-04  3.350221e-04
## ASV3883     -1.699284e-04 -1.780449e-04 -1.865493e-04 -1.954600e-04
## ASV0801      1.695348e-04  1.777984e-04  1.864712e-04  1.955737e-04
## ASV1611     -6.462092e-04 -6.764853e-04 -7.081565e-04 -7.412848e-04
## ASV0227     -2.357088e-04 -2.472108e-04 -2.592844e-04 -2.719588e-04
## ASV0833      2.531780e-04  2.655150e-04  2.784632e-04  2.920533e-04
## ASV0718      6.011843e-04  6.291481e-04  6.583820e-04  6.889409e-04
## ASV1139      2.185782e-04  2.281035e-04  2.380009e-04  2.482807e-04
## ASV0766     -1.635950e-04 -1.710105e-04 -1.787443e-04 -1.868083e-04
## ASV2091      8.039694e-04  8.402503e-04  8.780753e-04  9.175020e-04
## ASV1238     -4.966960e-05 -5.143901e-05 -5.323851e-05 -5.506481e-05
## ASV9193     -7.362736e-05 -7.750001e-05 -8.158956e-05 -8.590906e-05
## ASV0290     -6.811662e-05 -7.159384e-05 -7.525669e-05 -7.911557e-05
## ASV0231      6.371640e-04  6.665598e-04  6.972683e-04  7.293443e-04
## ASV0185      1.176520e-04  1.246890e-04  1.321920e-04  1.401947e-04
## ASV2330      1.836690e-04  1.919935e-04  2.006757e-04  2.097293e-04
## ASV3119     -2.108282e-04 -2.212691e-04 -2.322431e-04 -2.437788e-04
## ASV2368     -2.913250e-04 -3.051793e-04 -3.196915e-04 -3.348927e-04
## ASV0122     -2.283509e-04 -2.385731e-04 -2.492230e-04 -2.603157e-04
## ASV1044      4.006126e-04  4.199443e-04  4.402186e-04  4.614822e-04
## ASV0160     -5.627742e-04 -5.877625e-04 -6.137750e-04 -6.408459e-04
## ASV0326      3.661937e-04  3.832383e-04  4.010578e-04  4.196854e-04
## ASV1388      6.410898e-04  6.707495e-04  7.017408e-04  7.341196e-04
## ASV0792      7.258021e-04  7.590022e-04  7.936572e-04  8.298252e-04
## ASV0036     -4.595359e-04 -4.811830e-04 -5.038381e-04 -5.275469e-04
## ASV2125      7.495348e-04  7.841912e-04  8.204018e-04  8.582317e-04
## ASV1075      1.436501e-04  1.505157e-04  1.577103e-04  1.652500e-04
## ASV0390      1.415482e-04  1.486408e-04  1.561035e-04  1.639568e-04
## ASV3790     -6.028026e-04 -6.309959e-04 -6.604835e-04 -6.913225e-04
## ASV1535     -4.964652e-05 -5.216615e-05 -5.482031e-05 -5.761673e-05
## ASV0263      1.244461e-04  1.302484e-04  1.363151e-04  1.426579e-04
## ASV0675      9.914899e-04  1.038504e-03  1.087736e-03  1.139290e-03
## ASV3348      9.546758e-05  1.001516e-04  1.050714e-04  1.102393e-04
## ASV0058     -9.449383e-04 -9.884756e-04 -1.033950e-03 -1.081442e-03
## ASV4142      2.368836e-04  2.477593e-04  2.591142e-04  2.709676e-04
## ASV0059     -8.147255e-04 -8.521888e-04 -8.913120e-04 -9.321628e-04
## ASV0013     -1.700803e-03 -1.779415e-03 -1.861549e-03 -1.947354e-03
## ASV0033     -5.004064e-04 -5.240234e-04 -5.487444e-04 -5.746198e-04
## ASV4354     -2.173654e-04 -2.272069e-04 -2.374714e-04 -2.481751e-04
## ASV0022     -5.278924e-04 -5.527626e-04 -5.787910e-04 -6.060304e-04
## ASV0134     -1.315074e-04 -1.379393e-04 -1.446919e-04 -1.517816e-04
## ASV0415     -1.089259e-04 -1.133379e-04 -1.178906e-04 -1.225848e-04
## ASV10103    -3.691911e-04 -3.864656e-04 -4.045337e-04 -4.234303e-04
## ASV1613      5.960798e-04  6.233213e-04  6.517542e-04  6.814257e-04
## ASV0135     -3.023666e-05 -3.084474e-05 -3.140545e-05 -3.190977e-05
## ASV0469     -7.434791e-04 -7.773620e-04 -8.127189e-04 -8.496074e-04
## ASV0471      4.731238e-04  4.951564e-04  5.181910e-04  5.422711e-04
## ASV0451     -1.300243e-04 -1.364269e-04 -1.431533e-04 -1.502206e-04
## ASV0747      1.847264e-04  1.937268e-04  2.031735e-04  2.130889e-04
## ASV1314     -2.826360e-04 -2.962875e-04 -3.106067e-04 -3.256269e-04
## ASV0425     -8.432863e-04 -8.812727e-04 -9.208687e-04 -9.621335e-04
## ASV0559     -4.797262e-04 -5.013113e-04 -5.238106e-04 -5.472581e-04
## ASV0148     -5.200730e-04 -5.433854e-04 -5.676742e-04 -5.929742e-04
## ASV0129     -2.573640e-04 -2.684243e-04 -2.799017e-04 -2.918061e-04
## ASV1072      2.523333e-04  2.635659e-04  2.752614e-04  2.874353e-04
## ASV2390      1.799562e-04  1.879699e-04  1.963139e-04  2.049991e-04
## ASV0548      5.453268e-04  5.708019e-04  5.974441e-04  6.253047e-04
## ASV0168     -8.200972e-04 -8.576278e-04 -8.968057e-04 -9.376969e-04
## ASV0066     -6.083464e-04 -6.363392e-04 -6.655744e-04 -6.961030e-04
## ASV0468     -2.248374e-04 -2.352693e-04 -2.461726e-04 -2.575673e-04
## ASV0172     -1.259863e-04 -1.309940e-04 -1.361497e-04 -1.414526e-04
## ASV0236     -3.141231e-04 -3.275299e-04 -3.414335e-04 -3.558450e-04
## ASV0250      1.874177e-05  2.090270e-05  2.328228e-05  2.590109e-05
## ASV0338     -4.332353e-05 -4.462454e-05 -4.591987e-05 -4.720359e-05
## ASV0450     -2.843025e-06 -2.961280e-06 -3.083521e-06 -3.209787e-06
## ASV0377      6.685702e-04  6.995328e-04  7.318887e-04  7.656970e-04
## ASV1022      1.862183e-04  1.949086e-04  2.039965e-04  2.134996e-04
## ASV6174     -4.583763e-05 -4.789133e-05 -5.003170e-05 -5.226199e-05
## ASV0786      7.445020e-05  7.769994e-05  8.107795e-05  8.458808e-05
## ASV0053     -8.045582e-04 -8.419183e-04 -8.809688e-04 -9.217819e-04
## ASV0697     -2.320784e-04 -2.423687e-04 -2.530799e-04 -2.642260e-04
## ASV0785      5.989020e-04  6.266726e-04  6.556960e-04  6.860254e-04
## ASV1967     -3.945989e-04 -4.123372e-04 -4.308256e-04 -4.500916e-04
## ASV0385     -1.839945e-04 -1.920898e-04 -2.005101e-04 -2.092658e-04
## ASV0295      2.975863e-06  3.800145e-06  4.726274e-06  5.764641e-06
## ASV0072     -6.406657e-04 -6.696037e-04 -6.997748e-04 -7.312246e-04
## ASV0157     -2.653723e-04 -2.770270e-04 -2.891456e-04 -3.017422e-04
## ASV0501      2.936707e-04  3.077837e-04  3.225800e-04  3.380931e-04
## ASV10729    -4.904273e-04 -5.133562e-04 -5.373366e-04 -5.624149e-04
## ASV1470      2.326321e-04  2.431991e-04  2.542222e-04  2.657188e-04
## ASV0050     -1.605203e-03 -1.679010e-03 -1.756088e-03 -1.836572e-03
## ASV0411     -4.095645e-05 -4.253301e-05 -4.415035e-05 -4.580739e-05
## ASV0549      3.056569e-04  3.202684e-04  3.355806e-04  3.516273e-04
## ASV0184      1.874652e-04  1.961455e-04  2.052170e-04  2.146966e-04
## ASV0705      2.263143e-04  2.370226e-04  2.482332e-04  2.599690e-04
## ASV1715      5.703261e-04  5.968829e-04  6.246485e-04  6.536752e-04
## ASV0603      6.797008e-05  7.123524e-05  7.465877e-05  7.824848e-05
## ASV0826      1.904909e-04  1.990467e-04  2.079626e-04  2.172516e-04
## ASV0034     -7.249250e-04 -7.579810e-04 -7.924751e-04 -8.284634e-04
## ASV0838      1.529655e-04  1.599724e-04  1.672864e-04  1.749197e-04
## ASV0614     -4.121433e-04 -4.310100e-04 -4.507054e-04 -4.712627e-04
## ASV0014     -1.556158e-03 -1.627782e-03 -1.702588e-03 -1.780706e-03
## ASV0585     -9.803123e-05 -1.026438e-04 -1.074705e-04 -1.125211e-04
## ASV0016     -1.590919e-03 -1.664181e-03 -1.740699e-03 -1.820610e-03
## ASV5394     -4.039092e-04 -4.227580e-04 -4.424679e-04 -4.630764e-04
## ASV0666      3.429814e-04  3.587575e-04  3.752332e-04  3.924371e-04
## ASV2085      1.335314e-04  1.389249e-04  1.444881e-04  1.502217e-04
## ASV0003     -1.454821e-03 -1.521656e-03 -1.591449e-03 -1.664320e-03
## ASV0346     -2.589900e-05 -2.629001e-05 -2.662392e-05 -2.689153e-05
## ASV0267     -2.294791e-04 -2.396110e-04 -2.501516e-04 -2.611136e-04
## ASV0353      3.122266e-04  3.275142e-04  3.435673e-04  3.604255e-04
## ASV2419      4.106157e-04  4.293854e-04  4.489771e-04  4.694236e-04
## ASV0447      1.970115e-04  2.070343e-04  2.175910e-04  2.287118e-04
## ASV0654      6.373556e-04  6.672668e-04  6.985598e-04  7.312963e-04
## ASV0151      1.002818e-04  1.054986e-04  1.110049e-04  1.168181e-04
## ASV0065     -5.874315e-04 -6.145050e-04 -6.427839e-04 -6.723179e-04
## ASV0527      4.251972e-04  4.448270e-04  4.653344e-04  4.867559e-04
## ASV4055     -1.596924e-04 -1.673608e-04 -1.754002e-04 -1.838289e-04
## ASV0166     -4.884799e-04 -5.105538e-04 -5.335703e-04 -5.575646e-04
## ASV0417     -4.131432e-04 -4.320393e-04 -4.517639e-04 -4.723503e-04
## ASV0078     -3.309260e-04 -3.458540e-04 -3.614155e-04 -3.776339e-04
## ASV0322     -4.026698e-04 -4.208303e-04 -4.397617e-04 -4.594923e-04
## ASV0156     -5.233815e-04 -5.472438e-04 -5.721457e-04 -5.981279e-04
## ASV0648     -4.740847e-04 -4.963690e-04 -5.196865e-04 -5.440837e-04
## ASV0407      3.702725e-05  3.897237e-05  4.102686e-05  4.319742e-05
## ASV2030     -1.003591e-04 -1.046942e-04 -1.091972e-04 -1.138732e-04
## ASV0300      2.789082e-04  2.924848e-04  3.067337e-04  3.216890e-04
## ASV1150     -3.529379e-05 -3.669353e-05 -3.813392e-05 -3.961455e-05
## ASV0958      2.911570e-04  3.053169e-04  3.201782e-04  3.357766e-04
## ASV0216     -4.970416e-04 -5.194201e-04 -5.427473e-04 -5.670582e-04
## ASV0446      6.956196e-04  7.287881e-04  7.635368e-04  7.999408e-04
## ASV0367     -2.375695e-04 -2.485088e-04 -2.599347e-04 -2.718674e-04
## ASV0200     -4.430534e-04 -4.636108e-04 -4.850975e-04 -5.075534e-04
## ASV0334     -2.265228e-04 -2.360217e-04 -2.458564e-04 -2.560330e-04
## ASV1311      3.121153e-04  3.264035e-04  3.413189e-04  3.568866e-04
## ASV0458      3.373817e-04  3.529045e-04  3.691175e-04  3.860493e-04
## ASV1371      1.034582e-05  1.086254e-05  1.140612e-05  1.197803e-05
## ASV0418      4.123209e-04  4.314471e-04  4.514374e-04  4.723288e-04
## ASV0004      4.893555e-04  5.119760e-04  5.356104e-04  5.603011e-04
## ASV1943      3.569390e-04  3.731843e-04  3.901360e-04  4.078219e-04
## ASV1495     -8.926826e-05 -9.394067e-05 -9.887394e-05 -1.040839e-04
## ASV0901     -5.587690e-04 -5.851455e-04 -6.127563e-04 -6.416580e-04
## ASV0628      3.251910e-04  3.399586e-04  3.553628e-04  3.714280e-04
## ASV0400      1.303035e-04  1.362318e-04  1.424166e-04  1.488675e-04
## ASV0116     -4.310014e-04 -4.515889e-04 -4.731617e-04 -4.957669e-04
## ASV0788      3.541143e-04  3.705850e-04  3.878037e-04  4.058025e-04
## ASV0117      2.290884e-04  2.401823e-04  2.518211e-04  2.640321e-04
## ASV3137      6.217717e-05  6.500138e-05  6.794763e-05  7.102066e-05
## ASV0001      5.854907e-04  6.118908e-04  6.394124e-04  6.680969e-04
## ASV1651      3.904791e-04  4.080853e-04  4.264400e-04  4.455711e-04
## ASV1692      4.197995e-04  4.398247e-04  4.608057e-04  4.827878e-04
## ASV0660      2.386182e-04  2.491331e-04  2.600702e-04  2.714425e-04
## ASV0508      2.893915e-05  3.006543e-05  3.122342e-05  3.241287e-05
## ASV1660     -1.727822e-04 -1.811587e-04 -1.899463e-04 -1.991654e-04
## ASV0233      9.617069e-05  1.008476e-04  1.057564e-04  1.109090e-04
## ASV1343     -4.215747e-04 -4.413022e-04 -4.619366e-04 -4.835183e-04
## ASV0209      3.882939e-04  4.057022e-04  4.238411e-04  4.427367e-04
## ASV0193     -5.060204e-04 -5.289905e-04 -5.529514e-04 -5.779413e-04
## ASV0357     -2.822021e-05 -2.902082e-05 -2.980926e-05 -3.058040e-05
## ASV0198      1.086786e-04  1.137847e-04  1.191276e-04  1.247177e-04
## ASV0007      5.550259e-04  5.800512e-04  6.061394e-04  6.333300e-04
## ASV1772     -5.685810e-05 -5.944244e-05 -6.213793e-05 -6.494872e-05
## ASV0009      5.234406e-04  5.469961e-04  5.715478e-04  5.971322e-04
## ASV0006      2.091571e-04  2.181080e-04  2.273934e-04  2.370210e-04
## ASV0011     -5.894777e-04 -6.171882e-04 -6.461841e-04 -6.765233e-04
## ASV0015      4.114203e-04  4.304667e-04  4.503690e-04  4.711633e-04
## ASV0017      4.355148e-04  4.556380e-04  4.766621e-04  4.986249e-04
## ASV0235     -3.441653e-04 -3.603200e-04 -3.772212e-04 -3.949022e-04
## ASV0382      6.360085e-05  6.727410e-05  7.117926e-05  7.533209e-05
## ASV2357      5.229620e-04  5.473743e-04  5.729037e-04  5.995993e-04
## ASV0567     -3.785884e-04 -3.959078e-04 -4.139880e-04 -4.328596e-04
## ASV0165      4.151003e-04  4.343246e-04  4.544142e-04  4.754058e-04
## ASV0005      8.349744e-04  8.732122e-04  9.131296e-04  9.547939e-04
## ASV0384     -3.815669e-05 -3.948146e-05 -4.082351e-05 -4.217953e-05
## ASV0002      1.801357e-04  1.888374e-04  1.979646e-04  2.075386e-04
## ASV3017      4.863760e-04  5.084799e-04  5.315390e-04  5.555901e-04
## ASV0091      1.880924e-04  1.970132e-04  2.063550e-04  2.161373e-04
## ASV0186     -5.037501e-04 -5.272887e-04 -5.519056e-04 -5.776481e-04
## ASV0370      5.155922e-05  5.406712e-05  5.669901e-05  5.946117e-05
## ASV0018      8.699817e-04  9.099103e-04  9.516011e-04  9.951255e-04
## ASV1377      7.593165e-04  7.940727e-04  8.303550e-04  8.682247e-04
## ASV0019      8.711358e-04  9.111269e-04  9.528839e-04  9.964785e-04
## ASV0023      5.823831e-05  6.020628e-05  6.219514e-05  6.419961e-05
## ASV2194      2.851563e-04  2.986542e-04  3.127874e-04  3.275854e-04
## ASV1155     -3.106356e-05 -3.216474e-05 -3.328273e-05 -3.441507e-05
## ASV0510     -3.177461e-04 -3.316186e-04 -3.460369e-04 -3.610169e-04
## ASV2371     -3.125767e-04 -3.264927e-04 -3.409849e-04 -3.560735e-04
## ASV0024      1.635604e-05  1.637758e-05  1.633182e-05  1.620967e-05
## ASV2452      4.082870e-04  4.266836e-04  4.458592e-04  4.658421e-04
## ASV2332      2.344083e-05  2.523049e-05  2.716407e-05  2.925320e-05
## ASV2591      2.152852e-05  2.323189e-05  2.507505e-05  2.706939e-05
## ASV0521      5.614604e-04  5.880793e-04  6.159541e-04  6.451432e-04
## ASV5542      1.746073e-04  1.830566e-04  1.919181e-04  2.012121e-04
## ASV0336     -2.623369e-04 -2.744328e-04 -2.870682e-04 -3.002655e-04
## ASV10102     3.892484e-04  4.075545e-04  4.267097e-04  4.467521e-04
## ASV16823    -3.024004e-04 -3.157656e-04 -3.296756e-04 -3.441484e-04
## ASV3104      3.023659e-04  3.157280e-04  3.296346e-04  3.441037e-04
## ASV0781      1.470219e-04  1.537446e-04  1.607613e-04  1.680837e-04
## ASV10899     1.446208e-04  1.519858e-04  1.597432e-04  1.679153e-04
## ASV11222    -3.023434e-04 -3.157036e-04 -3.296081e-04 -3.440751e-04
## ASV11327    -3.023089e-04 -3.156660e-04 -3.295672e-04 -3.440304e-04
## ASV12458    -3.022744e-04 -3.156285e-04 -3.295262e-04 -3.439858e-04
## ASV1636     -2.470352e-04 -2.579092e-04 -2.692212e-04 -2.809854e-04
## ASV1890     -3.017306e-04 -3.151976e-04 -3.292265e-04 -3.438374e-04
## ASV2898      6.555261e-04  6.854843e-04  7.167530e-04  7.493841e-04
## ASV8328     -4.762573e-05 -4.903109e-05 -5.042704e-05 -5.180677e-05
## ASV0709     -5.363235e-04 -5.609216e-04 -5.866030e-04 -6.134112e-04
## ASV0856      8.703599e-05  9.135554e-05  9.589589e-05  1.006687e-04
## ASV0909     -2.231950e-04 -2.325840e-04 -2.423077e-04 -2.523721e-04
## ASV0937     -4.197319e-04 -4.393141e-04 -4.597930e-04 -4.812082e-04
## ASV11390    -3.022011e-04 -3.155486e-04 -3.294393e-04 -3.438913e-04
## ASV11966     1.579006e-04  1.656816e-04  1.738552e-04  1.824416e-04
## ASV12990     8.338765e-05  8.732843e-05  9.145237e-05  9.576754e-05
## ASV14797     3.141304e-04  3.283163e-04  3.431063e-04  3.585227e-04
## ASV14904    -3.021921e-04 -3.155390e-04 -3.294290e-04 -3.438802e-04
## ASV15304     8.497578e-05  8.945717e-05  9.418938e-05  9.918734e-05
## ASV16696    -3.021643e-04 -3.155088e-04 -3.293962e-04 -3.438446e-04
## ASV1690      1.612671e-04  1.693553e-04  1.778626e-04  1.868117e-04
## ASV2029      8.424846e-04  8.812185e-04  9.216692e-04  9.639070e-04
## ASV2834      4.525089e-04  4.735650e-04  4.955786e-04  5.185914e-04
## ASV4003      1.332290e-04  1.401747e-04  1.475039e-04  1.552391e-04
## ASV4064      3.176533e-04  3.326640e-04  3.483770e-04  3.648242e-04
## ASV4294      1.121835e-04  1.179621e-04  1.240543e-04  1.304782e-04
## ASV4609     -1.168307e-05 -1.203626e-05 -1.238917e-05 -1.274048e-05
## ASV6283     -3.021618e-04 -3.155064e-04 -3.293941e-04 -3.438430e-04
## ASV6491     -3.021273e-04 -3.154689e-04 -3.293532e-04 -3.437984e-04
## ASV7453      1.236567e-04  1.300059e-04  1.366974e-04  1.437505e-04
## ASV7959      2.690961e-05  2.876589e-05  3.076066e-05  3.290462e-05
## ASV8219      3.021043e-04  3.154440e-04  3.293264e-04  3.437695e-04
## ASV8547     -3.020699e-04 -3.154065e-04 -3.292855e-04 -3.437249e-04
## ASV9319      2.077090e-04  2.176030e-04  2.279669e-04  2.388225e-04
## ASV9382     -3.020492e-04 -3.153841e-04 -3.292612e-04 -3.436986e-04
## ASV11516    -3.020148e-04 -3.153466e-04 -3.292203e-04 -3.436541e-04
## ASV14377    -3.019804e-04 -3.153091e-04 -3.291795e-04 -3.436095e-04
## ASV1867      4.485106e-04  4.696041e-04  4.916763e-04  5.147710e-04
## ASV1895     -1.027029e-04 -1.071781e-04 -1.118298e-04 -1.166633e-04
## ASV3168      1.897316e-04  1.983554e-04  2.073500e-04  2.167290e-04
## ASV4449      3.774470e-04  3.943981e-04  4.120659e-04  4.304768e-04
## ASV6596      2.214388e-04  2.323554e-04  2.438245e-04  2.558752e-04
## ASV7492     -1.100829e-04 -1.144303e-04 -1.189059e-04 -1.235095e-04
## ASV9854     -1.547937e-04 -1.614974e-04 -1.684623e-04 -1.756961e-04
## ASV6296      3.019089e-04  3.152314e-04  3.290951e-04  3.435179e-04
## ASV4201      1.045639e-04  1.102985e-04  1.163725e-04  1.228074e-04
## ASV0552      7.507482e-04  7.861195e-04  8.231383e-04  8.618796e-04
## ASV3671     -5.997657e-05 -6.220116e-05 -6.447713e-05 -6.680257e-05
## ASV3529     -6.335204e-05 -6.555867e-05 -6.780009e-05 -7.007229e-05
## ASV1060      1.892728e-04  1.982357e-04  2.076212e-04  2.174490e-04
## ASV0239     -4.222287e-04 -4.410080e-04 -4.605605e-04 -4.809123e-04
## ASV5711     -3.891285e-04 -4.065864e-04 -4.247806e-04 -4.437380e-04
## ASV4152     -5.162801e-04 -5.398740e-04 -5.645024e-04 -5.902068e-04
## ASV1461      4.581923e-04  4.786937e-04  5.000505e-04  5.222927e-04
## ASV2877      3.756373e-04  3.928644e-04  4.108497e-04  4.296235e-04
## ASV0012      2.844952e-04  2.981254e-04  3.124114e-04  3.273849e-04
## ASV9823      1.009706e-04  1.053812e-04  1.099651e-04  1.147273e-04
## ASV0008      3.103773e-04  3.251464e-04  3.406173e-04  3.568231e-04
## ASV7832     -3.171295e-04 -3.314930e-04 -3.464754e-04 -3.621008e-04
## ASV1915      2.665097e-05  2.820197e-05  2.985040e-05  3.160267e-05
## ASV0055      2.191452e-04  2.292650e-04  2.398369e-04  2.508798e-04
## ASV0032      5.283036e-04  5.522858e-04  5.773026e-04  6.033938e-04
## ASV2977     -4.347200e-04 -4.545750e-04 -4.752994e-04 -4.969280e-04
## ASV0466      4.390572e-04  4.587889e-04  4.793535e-04  5.007815e-04
## ASV3866      4.665691e-04  4.884419e-04  5.113234e-04  5.352585e-04
## ASV0040      6.214015e-04  6.507682e-04  6.815114e-04  7.136944e-04
## ASV0496     -3.602170e-05 -3.831276e-05 -4.076480e-05 -4.338994e-05
## ASV0052      7.523179e-04  7.868842e-04  8.229798e-04  8.606670e-04
## ASV3828     -4.623918e-04 -4.834401e-04 -5.054048e-04 -5.283220e-04
## ASV1930      2.896687e-04  3.031378e-04  3.172162e-04  3.319298e-04
## ASV2126      4.702245e-04  4.919142e-04  5.145708e-04  5.382345e-04
## ASV0793      2.858968e-04  2.998277e-04  3.144493e-04  3.297969e-04
## ASV0299     -1.944071e-04 -2.027555e-04 -2.114205e-04 -2.204101e-04
## ASV0208      4.413206e-04  4.623465e-04  4.843739e-04  5.074504e-04
## ASV0511     -2.355595e-04 -2.456514e-04 -2.561209e-04 -2.669768e-04
## ASV1123     -3.122253e-04 -3.260372e-04 -3.404111e-04 -3.553653e-04
## ASV0099     -1.724401e-04 -1.802660e-04 -1.884274e-04 -1.969366e-04
## ASV0752     -3.703458e-05 -3.906782e-05 -4.122056e-05 -4.350022e-05
## ASV0883      5.490037e-06  5.938881e-06  6.425381e-06  6.952646e-06
## ASV0683      3.940766e-04  4.128147e-04  4.324410e-04  4.529972e-04
## ASV4117     -4.656123e-04 -4.868503e-04 -5.090167e-04 -5.321484e-04
## ASV2172      1.746375e-04  1.827807e-04  1.912949e-04  2.001962e-04
## ASV0330     -3.172516e-04 -3.320634e-04 -3.475523e-04 -3.637477e-04
## ASV0728      3.026191e-04  3.170792e-04  3.322295e-04  3.481027e-04
## ASV0499      5.946330e-04  6.228999e-04  6.525078e-04  6.835199e-04
## ASV0120     -6.572598e-04 -6.876897e-04 -7.194866e-04 -7.527078e-04
## ASV1446      5.246134e-05  5.440186e-05  5.638505e-05  5.840872e-05
## ASV17171    -4.425376e-04 -4.627931e-04 -4.839404e-04 -5.060160e-04
## ASV0533      1.266125e-04  1.327124e-04  1.391092e-04  1.458175e-04
## ASV2495     -1.802919e-04 -1.888095e-04 -1.977285e-04 -2.070679e-04
## ASV5582      1.550474e-04  1.618081e-04  1.688337e-04  1.761320e-04
## ASV1488      1.435953e-04  1.504696e-04  1.576737e-04  1.652234e-04
## ASV0682      4.139626e-04  4.336307e-04  4.542307e-04  4.758063e-04
## ASV0068     -2.670911e-05 -2.843537e-05 -3.028422e-05 -3.226489e-05
## ASV1987     -2.257062e-04 -2.367873e-04 -2.484246e-04 -2.606469e-04
## ASV0035      7.474122e-05  7.740892e-05  8.012100e-05  8.287210e-05
## ASV7192     -2.968213e-04 -3.100729e-04 -3.238764e-04 -3.382511e-04
## ASV0873      4.226002e-05  4.377969e-05  4.532903e-05  4.690601e-05
## ASV4749      2.216613e-05  2.243201e-05  2.263858e-05  2.277674e-05
## ASV2174      2.816989e-04  2.941530e-04  3.071134e-04  3.205969e-04
## ASV1476     -2.467644e-04 -2.582462e-04 -2.702518e-04 -2.828044e-04
## ASV0740     -6.021472e-04 -6.306827e-04 -6.605630e-04 -6.918505e-04
## ASV0170      1.276352e-04  1.335551e-04  1.397428e-04  1.462099e-04
## ASV2466     -5.447555e-04 -5.699198e-04 -5.962131e-04 -6.236834e-04
## ASV1709      4.222797e-04  4.416206e-04  4.618132e-04  4.828921e-04
## ASV6170     -3.897716e-04 -4.080381e-04 -4.271468e-04 -4.471350e-04
## ASV3673      4.462381e-04  4.671746e-04  4.890786e-04  5.119934e-04
## ASV1745      3.434069e-05  3.596999e-05  3.767593e-05  3.946202e-05
##                                                                    
## (Intercept) -7.721446e-06 -8.806188e-06 -1.003957e-05 -1.144122e-05
## ASV1236      3.804688e-04  3.975105e-04  4.152662e-04  4.337615e-04
## ASV0421     -6.776574e-04 -7.081997e-04 -7.400389e-04 -7.732230e-04
## ASV0691     -5.863524e-04 -6.120673e-04 -6.388096e-04 -6.666117e-04
## ASV0899     -5.999148e-06 -5.806429e-06 -5.564726e-06 -5.268751e-06
## ASV1004      7.703753e-04  8.051272e-04  8.413569e-04  8.791191e-04
## ASV1041     -5.216233e-04 -5.451800e-04 -5.697396e-04 -5.953392e-04
## ASV1058      7.161536e-04  7.484744e-04  7.821723e-04  8.172986e-04
## ASV12542     2.181238e-04  2.276301e-04  2.375108e-04  2.477769e-04
## ASV1294      8.345008e-04  8.724978e-04  9.121441e-04  9.535041e-04
## ASV13113     3.033336e-04  3.177986e-04  3.329542e-04  3.488335e-04
## ASV1318      7.261618e-04  7.589687e-04  7.931754e-04  8.288343e-04
## ASV2269     -2.164552e-04 -2.262587e-04 -2.364819e-04 -2.471404e-04
## ASV2542      4.719937e-04  4.942193e-04  5.174791e-04  5.418200e-04
## ASV2660     -4.174644e-04 -4.360970e-04 -4.555032e-04 -4.757098e-04
## ASV2737     -2.314955e-05 -2.443512e-05 -2.579658e-05 -2.723854e-05
## ASV2840      5.548309e-04  5.794502e-04  6.050782e-04  6.317485e-04
## ASV3053      2.966301e-05  3.090575e-05  3.219353e-05  3.352741e-05
## ASV3077      1.729968e-04  1.807193e-04  1.887636e-04  1.971413e-04
## ASV3134      6.101430e-04  6.390932e-04  6.694122e-04  7.011643e-04
## ASV3140      2.671010e-04  2.796357e-04  2.927482e-04  3.064641e-04
## ASV3579      1.101517e-04  1.157812e-04  1.217139e-04  1.279671e-04
## ASV6119     -2.163961e-04 -2.261943e-04 -2.364116e-04 -2.470637e-04
## ASV7557     -2.163656e-04 -2.261609e-04 -2.363751e-04 -2.470239e-04
## ASV8422      1.191491e-04  1.243490e-04  1.297552e-04  1.353741e-04
## ASV1086     -5.976327e-05 -6.235825e-05 -6.505522e-05 -6.785733e-05
## ASV1310      4.131179e-04  4.319650e-04  4.516330e-04  4.721540e-04
## ASV15750    -1.020828e-04 -1.066286e-04 -1.113611e-04 -1.162866e-04
## ASV16905    -2.163538e-04 -2.261480e-04 -2.363610e-04 -2.470084e-04
## ASV2033      4.128080e-04  4.323622e-04  4.528368e-04  4.742744e-04
## ASV2089      1.483428e-04  1.550898e-04  1.621279e-04  1.694681e-04
## ASV2127      5.925565e-04  6.194059e-04  6.474089e-04  6.766095e-04
## ASV2725      6.677153e-04  6.974536e-04  7.284217e-04  7.606623e-04
## ASV2804     -2.163468e-04 -2.261404e-04 -2.363528e-04 -2.469996e-04
## ASV3075      4.264547e-04  4.459595e-04  4.663218e-04  4.875766e-04
## ASV3327      4.025105e-04  4.214550e-04  4.412807e-04  4.620279e-04
## ASV3342      4.370385e-04  4.573808e-04  4.786475e-04  5.008785e-04
## ASV3532     -3.941640e-04 -4.124839e-04 -4.316343e-04 -4.516509e-04
## ASV3600      4.992911e-04  5.224139e-04  5.465782e-04  5.718284e-04
## ASV4013      4.177825e-04  4.367875e-04  4.566161e-04  4.773005e-04
## ASV4136      4.127770e-04  4.312757e-04  4.505507e-04  4.706300e-04
## ASV4195      2.163034e-04  2.260930e-04  2.363011e-04  2.469433e-04
## ASV4407     -2.162729e-04 -2.260597e-04 -2.362647e-04 -2.469035e-04
## ASV4717      1.091171e-05  1.118618e-05  1.145338e-05  1.171144e-05
## ASV6794      2.216424e-04  2.313435e-04  2.414318e-04  2.519197e-04
## ASV8324     -2.162640e-04 -2.260499e-04 -2.362539e-04 -2.468916e-04
## ASV8981     -5.618602e-05 -5.841872e-05 -6.071666e-05 -6.307927e-05
## ASV9859      1.703455e-04  1.787717e-04  1.876285e-04  1.969390e-04
## ASV0936     -3.401977e-04 -3.556624e-04 -3.717969e-04 -3.886270e-04
## ASV12683    -3.592398e-05 -3.773072e-05 -3.963055e-05 -4.162829e-05
## ASV1293      5.008380e-04  5.233849e-04  5.468865e-04  5.713778e-04
## ASV13055    -5.209047e-05 -5.433761e-05 -5.666966e-05 -5.908861e-05
## ASV17063    -2.162127e-04 -2.259941e-04 -2.361933e-04 -2.468257e-04
## ASV2228      2.161822e-04  2.259608e-04  2.361569e-04  2.467859e-04
## ASV2769     -3.821036e-05 -3.964957e-05 -4.112276e-05 -4.262856e-05
## ASV2803      1.019083e-04  1.063040e-04  1.108691e-04  1.156086e-04
## ASV2896      2.739542e-04  2.866599e-04  2.999418e-04  3.138249e-04
## ASV3062      8.634276e-05  9.076969e-05  9.543624e-05  1.003563e-04
## ASV3107      3.299981e-04  3.453015e-04  3.612965e-04  3.780127e-04
## ASV3265      6.511502e-04  6.804260e-04  7.109380e-04  7.427311e-04
## ASV3666     -1.521710e-05 -1.597660e-05 -1.677511e-05 -1.761470e-05
## ASV4497      1.544013e-04  1.613635e-04  1.686222e-04  1.761886e-04
## ASV6914     -7.646517e-05 -8.004113e-05 -8.378031e-05 -8.768972e-05
## ASV0576     -7.652697e-04 -7.990523e-04 -8.342054e-04 -8.707740e-04
## ASV0673      2.034547e-04  2.132699e-04  2.235609e-04  2.343505e-04
## ASV0772      2.340850e-04  2.448130e-04  2.560145e-04  2.677090e-04
## ASV0862     -1.848563e-04 -1.928134e-04 -2.010732e-04 -2.096438e-04
## ASV0898      1.964150e-04  2.059270e-04  2.159042e-04  2.263697e-04
## ASV0910      4.228133e-04  4.429723e-04  4.640919e-04  4.862176e-04
## ASV0964     -2.776781e-04 -2.900286e-04 -3.028881e-04 -3.162742e-04
## ASV10059     1.981842e-04  2.077057e-04  2.176885e-04  2.281553e-04
## ASV10263    -2.163496e-04 -2.261439e-04 -2.363572e-04 -2.470049e-04
## ASV1088      2.248532e-04  2.356186e-04  2.469028e-04  2.587311e-04
## ASV1101      3.772028e-04  3.944704e-04  4.124945e-04  4.313052e-04
## ASV1183      2.420281e-04  2.532429e-04  2.649619e-04  2.772065e-04
## ASV11956     9.221223e-05  9.609863e-05  1.001263e-04  1.042983e-04
## ASV12774    -3.350391e-05 -3.517105e-05 -3.692299e-05 -3.876412e-05
## ASV1321      9.971170e-05  1.048936e-04  1.103611e-04  1.161310e-04
## ASV13793    -2.163141e-04 -2.261050e-04 -2.363146e-04 -2.469584e-04
## ASV14482    -2.083058e-05 -2.194719e-05 -2.312635e-05 -2.437160e-05
## ASV15483     1.539479e-04  1.611477e-04  1.686787e-04  1.765557e-04
## ASV2062      9.598042e-04  1.003807e-03  1.049749e-03  1.097708e-03
## ASV2132      4.395779e-04  4.601590e-04  4.816876e-04  5.042060e-04
## ASV2413      6.181033e-04  6.460296e-04  6.751497e-04  7.055087e-04
## ASV2490      4.051401e-04  4.231688e-04  4.419418e-04  4.614846e-04
## ASV2594      2.244920e-04  2.348142e-04  2.455968e-04  2.568591e-04
## ASV2822     -2.163654e-04 -2.261613e-04 -2.363762e-04 -2.470260e-04
## ASV2863      3.767878e-04  3.937002e-04  4.113244e-04  4.296863e-04
## ASV2910      4.910475e-04  5.130359e-04  5.359454e-04  5.598092e-04
## ASV2980      1.780282e-04  1.860249e-04  1.943574e-04  2.030377e-04
## ASV3307      2.163145e-04  2.261057e-04  2.363155e-04  2.469597e-04
## ASV3474      3.449896e-04  3.614900e-04  3.787814e-04  3.969018e-04
## ASV3502      7.095027e-04  7.421299e-04  7.762046e-04  8.117865e-04
## ASV4236      3.565164e-04  3.723877e-04  3.889147e-04  4.061198e-04
## ASV4842     -1.185380e-04 -1.239739e-04 -1.296479e-04 -1.355693e-04
## ASV4894     -2.163508e-04 -2.261455e-04 -2.363592e-04 -2.470075e-04
## ASV5290      2.680566e-04  2.803981e-04  2.932881e-04  3.067490e-04
## ASV5501      5.010267e-05  5.238997e-05  5.477840e-05  5.727226e-05
## ASV5795      1.819485e-04  1.905367e-04  1.995268e-04  2.089371e-04
## ASV5987     -2.163636e-04 -2.261596e-04 -2.363747e-04 -2.470246e-04
## ASV6267     -2.163330e-04 -2.261262e-04 -2.363382e-04 -2.469848e-04
## ASV6862      4.149835e-04  4.332649e-04  4.522847e-04  4.720672e-04
## ASV7145      7.570716e-05  7.895553e-05  8.232854e-05  8.582980e-05
## ASV7673     -2.163245e-04 -2.261168e-04 -2.363279e-04 -2.469734e-04
## ASV7789      8.217011e-05  8.644929e-05  9.096599e-05  9.573451e-05
## ASV7809     -2.501074e-05 -2.585878e-05 -2.671580e-05 -2.757948e-05
## ASV8002     -2.163027e-04 -2.260932e-04 -2.363024e-04 -2.469459e-04
## ASV8205      1.267782e-04  1.326227e-04  1.387291e-04  1.451086e-04
## ASV9155     -1.626879e-04 -1.700138e-04 -1.776492e-04 -1.856053e-04
## ASV9221     -2.272996e-05 -2.342815e-05 -2.412399e-05 -2.481421e-05
## ASV9311     -2.162624e-04 -2.260493e-04 -2.362546e-04 -2.468938e-04
## ASV9557     -2.162319e-04 -2.260160e-04 -2.362182e-04 -2.468541e-04
## ASV9936     -2.162014e-04 -2.259827e-04 -2.361818e-04 -2.468143e-04
## ASV1445      5.045299e-04  5.280660e-04  5.526777e-04  5.784120e-04
## ASV4232      4.284350e-04  4.487729e-04  4.700743e-04  4.923849e-04
## ASV6479      1.517531e-06  2.148674e-06  2.860295e-06  3.660559e-06
## ASV0142     -1.092480e-03 -1.141337e-03 -1.192235e-03 -1.245245e-03
## ASV0378     -3.565223e-04 -3.721929e-04 -3.884905e-04 -4.054345e-04
## ASV1122      6.669502e-04  6.980884e-04  7.306508e-04  7.646998e-04
## ASV0123     -1.069998e-03 -1.117810e-03 -1.167615e-03 -1.219483e-03
## ASV2064      1.094983e-04  1.141541e-04  1.189823e-04  1.239869e-04
## ASV4459     -1.183525e-04 -1.236595e-04 -1.291887e-04 -1.349479e-04
## ASV0448      1.945271e-04  2.042924e-04  2.145665e-04  2.253769e-04
## ASV0397      4.972960e-04  5.203161e-04  5.443708e-04  5.695037e-04
## ASV0485      6.937816e-04  7.255162e-04  7.586437e-04  7.932203e-04
## ASV1566      5.823867e-04  6.092971e-04  6.374123e-04  6.667825e-04
## ASV1365      3.777029e-04  3.952117e-04  4.135100e-04  4.326314e-04
## ASV1065      7.732258e-04  8.090133e-04  8.464087e-04  8.854799e-04
## ASV0722     -1.529734e-05 -1.587078e-05 -1.645875e-05 -1.706101e-05
## ASV12660    -3.593705e-04 -3.753588e-04 -3.920078e-04 -4.093403e-04
## ASV0223     -1.406441e-05 -1.464429e-05 -1.524317e-05 -1.586113e-05
## ASV0229      3.471904e-04  3.635045e-04  3.805750e-04  3.984358e-04
## ASV0877     -1.295115e-04 -1.350637e-04 -1.408249e-04 -1.468004e-04
## ASV0983      7.071657e-04  7.393186e-04  7.728633e-04  8.078537e-04
## ASV0626     -2.275934e-04 -2.371171e-04 -2.469770e-04 -2.571792e-04
## ASV4146     -3.846944e-05 -4.015878e-05 -4.191554e-05 -4.374181e-05
## ASV4175     -4.352983e-04 -4.553927e-04 -4.763843e-04 -4.983107e-04
## ASV2082     -3.403570e-05 -3.601688e-05 -3.812677e-05 -4.037472e-05
## ASV2272      3.157410e-04  3.305442e-04  3.460315e-04  3.622337e-04
## ASV2245     -3.797782e-04 -3.974246e-04 -4.158695e-04 -4.351470e-04
## ASV0590     -2.348941e-04 -2.464451e-04 -2.585782e-04 -2.713237e-04
## ASV0217     -3.405550e-04 -3.543781e-04 -3.686454e-04 -3.833601e-04
## ASV0416      3.480239e-04  3.631257e-04  3.788148e-04  3.951078e-04
## ASV1056      4.249624e-04  4.453266e-04  4.666697e-04  4.890387e-04
## ASV7777     -3.759150e-04 -3.932991e-04 -4.114630e-04 -4.304393e-04
## ASV0455      7.717639e-05  8.097644e-05  8.496680e-05  8.915704e-05
## ASV0604      8.596012e-05  9.056161e-05  9.542652e-05  1.005710e-04
## ASV6100     -3.474519e-04 -3.635692e-04 -3.804141e-04 -3.980177e-04
## ASV11359    -3.878367e-04 -4.056420e-04 -4.242334e-04 -4.436427e-04
## ASV6604      2.773646e-04  2.904476e-04  3.041419e-04  3.184756e-04
## ASV5004     -2.274827e-04 -2.379073e-04 -2.487904e-04 -2.601506e-04
## ASV1483     -2.102065e-04 -2.198975e-04 -2.300201e-04 -2.405920e-04
## ASV9773     -4.448511e-04 -4.654384e-04 -4.869507e-04 -5.094269e-04
## ASV4059      4.469942e-05  4.714747e-05  4.974095e-05  5.248927e-05
## ASV1193      7.235421e-04  7.569140e-04  7.917746e-04  8.281857e-04
## ASV4610     -5.901809e-05 -6.100772e-05 -6.302100e-05 -6.505333e-05
## ASV0742     -2.644866e-04 -2.756238e-04 -2.871608e-04 -2.991055e-04
## ASV1502     -6.181178e-06 -6.802960e-06 -7.483248e-06 -8.227229e-06
## ASV0195     -8.234479e-05 -8.657944e-05 -9.104192e-05 -9.574503e-05
## ASV1213      2.261356e-04  2.360331e-04  2.463229e-04  2.570167e-04
## ASV1648     -3.289381e-04 -3.441088e-04 -3.599565e-04 -3.765095e-04
## ASV6984     -2.467181e-04 -2.581846e-04 -2.701710e-04 -2.826998e-04
## ASV0396     -1.771469e-04 -1.838556e-04 -1.907305e-04 -1.977665e-04
## ASV4297      3.683281e-04  3.847483e-04  4.018497e-04  4.196561e-04
## ASV2622      8.407577e-04  8.786295e-04  9.181087e-04  9.592550e-04
## ASV3512      1.336953e-04  1.404923e-04  1.476526e-04  1.551969e-04
## ASV2411      2.932379e-04  3.072243e-04  3.218773e-04  3.372286e-04
## ASV2291     -7.612879e-05 -8.004069e-05 -8.416516e-05 -8.851461e-05
## ASV0807      3.468146e-04  3.638300e-04  3.816981e-04  4.004627e-04
## ASV1292      1.896971e-04  1.982399e-04  2.071458e-04  2.164283e-04
## ASV1035      8.760332e-05  9.134181e-05  9.522125e-05  9.924543e-05
## ASV0070     -1.954361e-04 -2.035644e-04 -2.119722e-04 -2.206634e-04
## ASV0255      8.183082e-05  8.559940e-05  8.953453e-05  9.364282e-05
## ASV0057     -8.634517e-04 -9.016135e-04 -9.413249e-04 -9.826362e-04
## ASV0077     -1.228505e-04 -1.277226e-04 -1.327383e-04 -1.378967e-04
## ASV0625      8.623097e-04  9.009174e-04  9.411408e-04  9.830374e-04
## ASV2464      4.159553e-04  4.343070e-04  4.534039e-04  4.732707e-04
## ASV1315      7.623266e-04  7.984328e-04  8.362383e-04  8.758218e-04
## ASV2673      5.559089e-04  5.824187e-04  6.101935e-04  6.392938e-04
## ASV2161      2.293263e-04  2.403173e-04  2.518380e-04  2.639140e-04
## ASV0337     -3.625886e-04 -3.791442e-04 -3.964227e-04 -4.144526e-04
## ASV7680     -4.279792e-04 -4.478489e-04 -4.686170e-04 -4.903219e-04
## ASV0611      9.341721e-04  9.780517e-04  1.023965e-03  1.072004e-03
## ASV3118     -3.171085e-04 -3.319581e-04 -3.474906e-04 -3.637362e-04
## ASV1284      3.346240e-04  3.502696e-04  3.666331e-04  3.837461e-04
## ASV0889      2.530672e-04  2.645832e-04  2.766001e-04  2.891375e-04
## ASV4649     -2.652375e-04 -2.774787e-04 -2.902663e-04 -3.036232e-04
## ASV1108     -3.428286e-04 -3.592586e-04 -3.764792e-04 -3.945288e-04
## ASV0738     -4.317778e-05 -4.371773e-05 -4.414768e-05 -4.445087e-05
## ASV0473      5.243896e-05  5.489290e-05  5.746050e-05  6.014699e-05
## ASV0598     -3.798478e-04 -3.965117e-04 -4.138408e-04 -4.318559e-04
## ASV0429      6.125553e-04  6.404976e-04  6.696570e-04  7.000810e-04
## ASV1549      6.198378e-04  6.495004e-04  6.805872e-04  7.131670e-04
## ASV1203      4.636070e-04  4.848748e-04  5.070808e-04  5.302626e-04
## ASV4532      1.928316e-05  1.996845e-05  2.066732e-05  2.137906e-05
## ASV0274     -4.606121e-04 -4.808980e-04 -5.020016e-04 -5.239494e-04
## ASV0163     -6.570632e-04 -6.858816e-04 -7.158501e-04 -7.470044e-04
## ASV1298      2.669323e-04  2.786363e-04  2.908080e-04  3.034623e-04
## ASV9424     -5.684816e-04 -5.950340e-04 -6.228024e-04 -6.518402e-04
## ASV0412      8.710240e-04  9.108154e-04  9.523488e-04  9.956940e-04
## ASV0284      3.865329e-04  4.036556e-04  4.214787e-04  4.400257e-04
## ASV0620     -2.949717e-04 -3.091503e-04 -3.240139e-04 -3.395957e-04
## ASV0153     -6.110637e-04 -6.399419e-04 -6.701732e-04 -7.018198e-04
## ASV0498      7.254456e-05  7.699681e-05  8.174792e-05  8.681914e-05
## ASV0097      4.384904e-04  4.593576e-04  4.812172e-04  5.041162e-04
## ASV0104     -2.006857e-03 -2.099102e-03 -2.195434e-03 -2.296021e-03
## ASV1282      3.506722e-04  3.670385e-04  3.841524e-04  4.020466e-04
## ASV3883     -2.047962e-04 -2.145783e-04 -2.248273e-04 -2.355653e-04
## ASV0801      2.051277e-04  2.151557e-04  2.256819e-04  2.367312e-04
## ASV1611     -7.759349e-04 -8.121742e-04 -8.500729e-04 -8.897037e-04
## ASV0227     -2.852645e-04 -2.992337e-04 -3.139004e-04 -3.293002e-04
## ASV0833      3.063179e-04  3.212911e-04  3.370088e-04  3.535085e-04
## ASV0718      7.208817e-04  7.542637e-04  7.891484e-04  8.255996e-04
## ASV1139      2.589534e-04  2.700291e-04  2.815176e-04  2.934286e-04
## ASV0766     -1.952148e-04 -2.039764e-04 -2.131060e-04 -2.226167e-04
## ASV2091      9.585891e-04  1.001397e-03  1.045986e-03  1.092420e-03
## ASV1238     -5.691408e-05 -5.878190e-05 -6.066321e-05 -6.255224e-05
## ASV9193     -9.047238e-05 -9.529426e-05 -1.003904e-04 -1.057775e-04
## ASV0290     -8.318151e-05 -8.746612e-05 -9.198171e-05 -9.674125e-05
## ASV0231      7.628444e-04  7.978272e-04  8.343536e-04  8.724861e-04
## ASV0185      1.487334e-04  1.578469e-04  1.675773e-04  1.779695e-04
## ASV2330      2.191682e-04  2.290068e-04  2.392598e-04  2.499422e-04
## ASV3119     -2.559062e-04 -2.686569e-04 -2.820646e-04 -2.961646e-04
## ASV2368     -3.508153e-04 -3.674936e-04 -3.849632e-04 -4.032615e-04
## ASV0122     -2.718668e-04 -2.838921e-04 -2.964077e-04 -3.094299e-04
## ASV1044      4.837842e-04  5.071759e-04  5.317113e-04  5.574472e-04
## ASV0160     -6.690097e-04 -6.983014e-04 -7.287562e-04 -7.604094e-04
## ASV0326      4.391562e-04  4.595061e-04  4.807726e-04  5.029946e-04
## ASV1388      7.679441e-04  8.032743e-04  8.401727e-04  8.787036e-04
## ASV0792      8.675657e-04  9.069404e-04  9.480127e-04  9.908475e-04
## ASV0036     -5.523571e-04 -5.783185e-04 -6.054830e-04 -6.339045e-04
## ASV2125      8.977487e-04  9.390229e-04  9.821267e-04  1.027135e-03
## ASV1075      1.731513e-04  1.814317e-04  1.901093e-04  1.992034e-04
## ASV0390      1.722224e-04  1.809233e-04  1.900838e-04  1.997299e-04
## ASV3790     -7.235722e-04 -7.572947e-04 -7.925542e-04 -8.294176e-04
## ASV1535     -6.056363e-05 -6.366972e-05 -6.694428e-05 -7.039717e-05
## ASV0263      1.492886e-04  1.562197e-04  1.634640e-04  1.710350e-04
## ASV0675      1.193275e-03  1.249802e-03  1.308991e-03  1.370964e-03
## ASV3348      1.156685e-04  1.213725e-04  1.273661e-04  1.336644e-04
## ASV0058     -1.131034e-03 -1.182811e-03 -1.236861e-03 -1.293276e-03
## ASV4142      2.833391e-04  2.962492e-04  3.097187e-04  3.237692e-04
## ASV0059     -9.748112e-04 -1.019330e-03 -1.065792e-03 -1.114277e-03
## ASV0013     -2.036983e-03 -2.130594e-03 -2.228353e-03 -2.330427e-03
## ASV0033     -6.017026e-04 -6.300476e-04 -6.597124e-04 -6.907568e-04
## ASV4354     -2.593348e-04 -2.709677e-04 -2.830913e-04 -2.957238e-04
## ASV0022     -6.345356e-04 -6.643638e-04 -6.955746e-04 -7.282302e-04
## ASV0134     -1.592257e-04 -1.670424e-04 -1.752506e-04 -1.838706e-04
## ASV0415     -1.274209e-04 -1.323986e-04 -1.375176e-04 -1.427764e-04
## ASV10103    -4.431920e-04 -4.638568e-04 -4.854641e-04 -5.080550e-04
## ASV1613      7.123844e-04  7.446804e-04  7.783651e-04  8.134915e-04
## ASV0135     -3.234769e-05 -3.270814e-05 -3.297883e-05 -3.314622e-05
## ASV0469     -8.880873e-04 -9.282196e-04 -9.700675e-04 -1.013696e-03
## ASV0471      5.674416e-04  5.937493e-04  6.212426e-04  6.499718e-04
## ASV0451     -1.576467e-04 -1.654505e-04 -1.736521e-04 -1.822726e-04
## ASV0747      2.234969e-04  2.344226e-04  2.458922e-04  2.579333e-04
## ASV1314     -3.413831e-04 -3.579122e-04 -3.752529e-04 -3.934461e-04
## ASV0425     -1.005127e-03 -1.049912e-03 -1.096549e-03 -1.145105e-03
## ASV0559     -5.716883e-04 -5.971366e-04 -6.236392e-04 -6.512332e-04
## ASV0148     -6.193205e-04 -6.467490e-04 -6.752960e-04 -7.049985e-04
## ASV0129     -3.041475e-04 -3.169353e-04 -3.301783e-04 -3.438848e-04
## ASV1072      3.001034e-04  3.132816e-04  3.269862e-04  3.412333e-04
## ASV2390      2.140367e-04  2.234382e-04  2.332149e-04  2.433782e-04
## ASV0548      6.544370e-04  6.848966e-04  7.167412e-04  7.500310e-04
## ASV0168     -9.803694e-04 -1.024893e-03 -1.071341e-03 -1.119788e-03
## ASV0066     -7.279777e-04 -7.612528e-04 -7.959846e-04 -8.322310e-04
## ASV0468     -2.694743e-04 -2.819153e-04 -2.949128e-04 -3.084902e-04
## ASV0172     -1.469012e-04 -1.524931e-04 -1.582251e-04 -1.640932e-04
## ASV0236     -3.707753e-04 -3.862345e-04 -4.022320e-04 -4.187765e-04
## ASV0250      2.878151e-05  3.194790e-05  3.542672e-05  3.924672e-05
## ASV0338     -4.846905e-05 -4.970884e-05 -5.091474e-05 -5.207761e-05
## ASV0450     -3.340102e-06 -3.474480e-06 -3.612920e-06 -3.755408e-06
## ASV0377      8.010189e-04  8.379178e-04  8.764595e-04  9.167119e-04
## ASV1022      2.234361e-04  2.338249e-04  2.446858e-04  2.560393e-04
## ASV6174     -5.458555e-05 -5.700580e-05 -5.952628e-05 -6.215062e-05
## ASV0786      8.823418e-05  9.202010e-05  9.594968e-05  1.000267e-04
## ASV0053     -9.644330e-04 -1.009000e-03 -1.055564e-03 -1.104208e-03
## ASV0697     -2.758212e-04 -2.878797e-04 -3.004162e-04 -3.134450e-04
## ASV0785      7.177161e-04  7.508256e-04  7.854132e-04  8.215405e-04
## ASV1967     -4.701636e-04 -4.910703e-04 -5.128414e-04 -5.355071e-04
## ASV0385     -2.183670e-04 -2.278241e-04 -2.376474e-04 -2.478473e-04
## ASV0295      6.926594e-06  8.224520e-06  9.671929e-06  1.128354e-05
## ASV0072     -7.639999e-04 -7.981486e-04 -8.337195e-04 -8.707624e-04
## ASV0157     -3.148306e-04 -3.284245e-04 -3.425376e-04 -3.571831e-04
## ASV0501      3.543580e-04  3.714117e-04  3.892927e-04  4.080416e-04
## ASV10729    -5.886392e-04 -6.160595e-04 -6.447279e-04 -6.746985e-04
## ASV1470      2.777068e-04  2.902047e-04  3.032314e-04  3.168061e-04
## ASV0050     -1.920598e-03 -2.008311e-03 -2.099857e-03 -2.195388e-03
## ASV0411     -4.750272e-05 -4.923460e-05 -5.100093e-05 -5.279917e-05
## ASV0549      3.684439e-04  3.860674e-04  4.045368e-04  4.238928e-04
## ASV0184      2.246016e-04  2.349502e-04  2.457611e-04  2.570538e-04
## ASV0705      2.722541e-04  2.851135e-04  2.985733e-04  3.126608e-04
## ASV1715      6.840178e-04  7.157328e-04  7.488791e-04  7.835179e-04
## ASV0603      8.201263e-05  8.595989e-05  9.009940e-05  9.444075e-05
## ASV0826      2.269270e-04  2.370023e-04  2.474911e-04  2.584074e-04
## ASV0034     -8.660039e-04 -9.051560e-04 -9.459805e-04 -9.885401e-04
## ASV0838      1.828847e-04  1.911943e-04  1.998614e-04  2.088997e-04
## ASV0614     -4.927162e-04 -5.151014e-04 -5.384545e-04 -5.628133e-04
## ASV0014     -1.862272e-03 -1.947425e-03 -2.036310e-03 -2.129077e-03
## ASV0585     -1.178057e-04 -1.233347e-04 -1.291191e-04 -1.351702e-04
## ASV0016     -1.904051e-03 -1.991167e-03 -2.082106e-03 -2.177021e-03
## ASV5394     -4.846226e-04 -5.071470e-04 -5.306920e-04 -5.553011e-04
## ASV0666      4.103989e-04  4.291491e-04  4.487193e-04  4.691420e-04
## ASV2085      1.561258e-04  1.621997e-04  1.684420e-04  1.748508e-04
## ASV0003     -1.740393e-03 -1.819797e-03 -1.902664e-03 -1.989133e-03
## ASV0346     -2.708270e-05 -2.718625e-05 -2.718991e-05 -2.708021e-05
## ASV0267     -2.725101e-04 -2.843537e-04 -2.966574e-04 -3.094339e-04
## ASV0353      3.781303e-04  3.967259e-04  4.162586e-04  4.367770e-04
## ASV2419      4.907587e-04  5.130172e-04  5.362350e-04  5.604491e-04
## ASV0447      2.404285e-04  2.527749e-04  2.657868e-04  2.795021e-04
## ASV0654      7.655404e-04  8.013590e-04  8.388217e-04  8.780007e-04
## ASV0151      1.229570e-04  1.294413e-04  1.362923e-04  1.435325e-04
## ASV0065     -7.031585e-04 -7.353589e-04 -7.689742e-04 -8.040609e-04
## ASV0527      5.091294e-04  5.324942e-04  5.568910e-04  5.823616e-04
## ASV4055     -1.926658e-04 -2.019310e-04 -2.116457e-04 -2.218320e-04
## ASV0166     -5.825730e-04 -6.086324e-04 -6.357808e-04 -6.640569e-04
## ASV0417     -4.938326e-04 -5.162461e-04 -5.396271e-04 -5.640131e-04
## ASV0078     -3.945327e-04 -4.121361e-04 -4.304687e-04 -4.495554e-04
## ASV0322     -4.800512e-04 -5.014677e-04 -5.237721e-04 -5.469948e-04
## ASV0156     -6.252329e-04 -6.535041e-04 -6.829862e-04 -7.137251e-04
## ASV0648     -5.696093e-04 -5.963137e-04 -6.242496e-04 -6.534718e-04
## ASV0407      4.549117e-05  4.791572e-05  5.047919e-05  5.319020e-05
## ASV2030     -1.187269e-04 -1.237633e-04 -1.289874e-04 -1.344041e-04
## ASV0300      3.373866e-04  3.538641e-04  3.711613e-04  3.893200e-04
## ASV1150     -4.113482e-05 -4.269386e-05 -4.429054e-05 -4.592343e-05
## ASV0958      3.521500e-04  3.693379e-04  3.873823e-04  4.063272e-04
## ASV0216     -5.923886e-04 -6.187753e-04 -6.462558e-04 -6.748682e-04
## ASV0446      8.380782e-04  8.780310e-04  9.198849e-04  9.637296e-04
## ASV0367     -2.843275e-04 -2.973368e-04 -3.109174e-04 -3.250924e-04
## ASV0200     -5.310199e-04 -5.555398e-04 -5.811578e-04 -6.079200e-04
## ASV0334     -2.665567e-04 -2.774323e-04 -2.886641e-04 -3.002554e-04
## ASV1311      3.731325e-04  3.900833e-04  4.077663e-04  4.262099e-04
## ASV0458      4.037295e-04  4.221887e-04  4.414588e-04  4.615725e-04
## ASV1371      1.257984e-05  1.321322e-05  1.387991e-05  1.458177e-05
## ASV0418      4.941597e-04  5.169699e-04  5.408008e-04  5.656953e-04
## ASV0004      5.860922e-04  6.130295e-04  6.411601e-04  6.705329e-04
## ASV1943      4.262709e-04  4.455127e-04  4.655778e-04  4.864977e-04
## ASV1495     -1.095872e-04 -1.154019e-04 -1.215470e-04 -1.280427e-04
## ASV0901     -6.719099e-04 -7.035739e-04 -7.367147e-04 -7.713996e-04
## ASV0628      3.881790e-04  4.056415e-04  4.238417e-04  4.428062e-04
## ASV0400      1.555948e-04  1.626087e-04  1.699198e-04  1.775390e-04
## ASV0116     -5.194539e-04 -5.442746e-04 -5.702833e-04 -5.975367e-04
## ASV0788      4.246151e-04  4.442762e-04  4.648221e-04  4.862903e-04
## ASV0117      2.768443e-04  2.902879e-04  3.043946e-04  3.191980e-04
## ASV3137      7.422532e-05  7.756660e-05  8.104962e-05  8.467964e-05
## ASV0001      6.979865e-04  7.291246e-04  7.615555e-04  7.953240e-04
## ASV1651      4.655071e-04  4.862771e-04  5.079109e-04  5.304390e-04
## ASV1692      5.058189e-04  5.299489e-04  5.552299e-04  5.817167e-04
## ASV0660      2.832631e-04  2.955449e-04  3.083009e-04  3.215438e-04
## ASV0508      3.363337e-05  3.488437e-05  3.616514e-05  3.747480e-05
## ASV1660     -2.088376e-04 -2.189852e-04 -2.296321e-04 -2.408029e-04
## ASV0233      1.163180e-04  1.219967e-04  1.279589e-04  1.342193e-04
## ASV1343     -5.060890e-04 -5.296924e-04 -5.543738e-04 -5.801804e-04
## ASV0209      4.624158e-04  4.829056e-04  5.042338e-04  5.264287e-04
## ASV0193     -6.039995e-04 -6.311661e-04 -6.594823e-04 -6.889907e-04
## ASV0357     -3.132851e-05 -3.204716e-05 -3.272916e-05 -3.336650e-05
## ASV0198      1.305662e-04  1.366847e-04  1.430854e-04  1.497807e-04
## ASV0007      6.616628e-04  6.911791e-04  7.219207e-04  7.539303e-04
## ASV1772     -6.787905e-05 -7.093322e-05 -7.411563e-05 -7.743072e-05
## ASV0009      6.237863e-04  6.515481e-04  6.804562e-04  7.105502e-04
## ASV0006      2.469985e-04  2.573332e-04  2.680318e-04  2.791009e-04
## ASV0011     -7.082664e-04 -7.414765e-04 -7.762191e-04 -8.125627e-04
## ASV0015      4.928871e-04  5.155791e-04  5.392793e-04  5.640292e-04
## ASV0017      5.215654e-04  5.455240e-04  5.705425e-04  5.966643e-04
## ASV0235     -4.133976e-04 -4.327436e-04 -4.529779e-04 -4.741394e-04
## ASV0382      7.974947e-05  8.444942e-05  8.945123e-05  9.477549e-05
## ASV2357      6.275120e-04  6.566950e-04  6.872037e-04  7.190953e-04
## ASV0567     -4.525542e-04 -4.731046e-04 -4.945446e-04 -5.169091e-04
## ASV0165      4.973373e-04  5.202484e-04  5.441797e-04  5.691736e-04
## ASV0005      9.982744e-04  1.043643e-03  1.090972e-03  1.140338e-03
## ASV0384     -4.354566e-05 -4.491749e-05 -4.628997e-05 -4.765736e-05
## ASV0002      2.175815e-04  2.281169e-04  2.391695e-04  2.507650e-04
## ASV3017      5.806710e-04  6.068206e-04  6.340787e-04  6.624862e-04
## ASV0091      2.263806e-04  2.371064e-04  2.483370e-04  2.600959e-04
## ASV0186     -6.045654e-04 -6.327088e-04 -6.621314e-04 -6.928884e-04
## ASV0370      6.236020e-05  6.540304e-05  6.859701e-05  7.194981e-05
## ASV0018      1.040557e-03  1.087972e-03  1.137449e-03  1.189068e-03
## ASV1377      9.077449e-04  9.489807e-04  9.919991e-04  1.036869e-03
## ASV0019      1.041985e-03  1.089479e-03  1.139039e-03  1.190747e-03
## ASV0023      6.621362e-05  6.823029e-05  7.024184e-05  7.223950e-05
## ASV2194      3.430792e-04  3.593010e-04  3.762847e-04  3.940656e-04
## ASV1155     -3.555889e-05 -3.671088e-05 -3.786724e-05 -3.902366e-05
## ASV0510     -3.765744e-04 -3.927251e-04 -4.094846e-04 -4.268681e-04
## ASV2371     -3.717789e-04 -3.881219e-04 -4.051239e-04 -4.228063e-04
## ASV0024      1.600112e-05  1.569521e-05  1.527991e-05  1.474207e-05
## ASV2452      4.866613e-04  5.083463e-04  5.309271e-04  5.544342e-04
## ASV2332      3.151040e-05  3.394917e-05  3.658401e-05  3.943051e-05
## ASV2591      2.922712e-05  3.156143e-05  3.408645e-05  3.681739e-05
## ASV0521      6.757079e-04  7.077123e-04  7.412233e-04  7.763109e-04
## ASV5542      2.109595e-04  2.211826e-04  2.319045e-04  2.431494e-04
## ASV0336     -3.140478e-04 -3.284391e-04 -3.434644e-04 -3.591491e-04
## ASV10102     4.677216e-04  4.896596e-04  5.126092e-04  5.366153e-04
## ASV16823    -3.592026e-04 -3.748570e-04 -3.911305e-04 -4.080424e-04
## ASV3104      3.591540e-04  3.748040e-04  3.910729e-04  4.079797e-04
## ASV0781      1.757237e-04  1.836935e-04  1.920059e-04  2.006738e-04
## ASV10899     1.765255e-04  1.855984e-04  1.951604e-04  2.052392e-04
## ASV11222    -3.591229e-04 -3.747705e-04 -3.910366e-04 -4.079404e-04
## ASV11327    -3.590743e-04 -3.747175e-04 -3.909790e-04 -4.078778e-04
## ASV12458    -3.590257e-04 -3.746646e-04 -3.909214e-04 -4.078151e-04
## ASV1636     -2.932160e-04 -3.059272e-04 -3.191334e-04 -3.328492e-04
## ASV1890     -3.590508e-04 -3.748880e-04 -3.913703e-04 -4.085197e-04
## ASV2898      7.834312e-04  8.189495e-04  8.559958e-04  8.946284e-04
## ASV8328     -5.316263e-05 -5.448612e-05 -5.576776e-05 -5.699708e-05
## ASV0709     -6.413913e-04 -6.705894e-04 -7.010533e-04 -7.328321e-04
## ASV0856      1.056865e-04  1.109621e-04  1.165093e-04  1.223427e-04
## ASV0909     -2.627830e-04 -2.735454e-04 -2.846639e-04 -2.961420e-04
## ASV0937     -5.036010e-04 -5.270145e-04 -5.514936e-04 -5.770849e-04
## ASV11390    -3.589229e-04 -3.745528e-04 -3.907999e-04 -4.076831e-04
## ASV11966     1.914624e-04  2.009401e-04  2.108983e-04  2.213621e-04
## ASV12990     1.002824e-04  1.050055e-04  1.099460e-04  1.151131e-04
## ASV14797     3.745885e-04  3.913270e-04  4.087622e-04  4.269184e-04
## ASV14904    -3.589111e-04 -3.745402e-04 -3.907864e-04 -4.076688e-04
## ASV15304     1.044669e-04  1.100448e-04  1.159389e-04  1.221681e-04
## ASV16696    -3.588724e-04 -3.744983e-04 -3.907410e-04 -4.076196e-04
## ASV1690      1.962262e-04  2.061311e-04  2.165527e-04  2.275187e-04
## ASV2029      1.008004e-03  1.054037e-03  1.102082e-03  1.152219e-03
## ASV2834      5.426466e-04  5.677892e-04  5.940657e-04  6.215247e-04
## ASV4003      1.634044e-04  1.720253e-04  1.811287e-04  1.907434e-04
## ASV4064      3.820390e-04  4.000562e-04  4.189121e-04  4.386446e-04
## ASV4294      1.372531e-04  1.443993e-04  1.519385e-04  1.598936e-04
## ASV4609     -1.308869e-05 -1.343218e-05 -1.376913e-05 -1.409756e-05
## ASV6283     -3.588714e-04 -3.744979e-04 -3.907415e-04 -4.076212e-04
## ASV6491     -3.588228e-04 -3.744451e-04 -3.906840e-04 -4.075586e-04
## ASV7453      1.511860e-04  1.590258e-04  1.672929e-04  1.760119e-04
## ASV7959      3.520922e-05  3.768682e-05  4.035064e-05  4.321491e-05
## ASV8219      3.587916e-04  3.744115e-04  3.906478e-04  4.075198e-04
## ASV8547     -3.587431e-04 -3.743587e-04 -3.905904e-04 -4.074572e-04
## ASV9319      2.501929e-04  2.621023e-04  2.745757e-04  2.876393e-04
## ASV9382     -3.587146e-04 -3.743278e-04 -3.905569e-04 -4.074211e-04
## ASV11516    -3.586661e-04 -3.742750e-04 -3.904995e-04 -4.073586e-04
## ASV14377    -3.586176e-04 -3.742222e-04 -3.904420e-04 -4.072961e-04
## ASV1867      5.389342e-04  5.642138e-04  5.906594e-04  6.183230e-04
## ASV1895     -1.216842e-04 -1.268979e-04 -1.323098e-04 -1.379253e-04
## ASV3168      2.265065e-04  2.366971e-04  2.473153e-04  2.583759e-04
## ASV4449      4.496581e-04  4.696376e-04  4.904441e-04  5.121067e-04
## ASV6596      2.685381e-04  2.818455e-04  2.958314e-04  3.105317e-04
## ASV7492     -1.282400e-04 -1.330960e-04 -1.380755e-04 -1.431757e-04
## ASV9854     -1.832064e-04 -1.910011e-04 -1.990878e-04 -2.074744e-04
## ASV6296      3.585182e-04  3.741144e-04  3.903252e-04  4.071695e-04
## ASV4201      1.296263e-04  1.368538e-04  1.445160e-04  1.526409e-04
## ASV0552      9.024214e-04  9.448452e-04  9.892358e-04  1.035682e-03
## ASV3671     -6.917514e-05 -7.159210e-05 -7.405024e-05 -7.654586e-05
## ASV3529     -7.237065e-05 -7.468992e-05 -7.702418e-05 -7.936672e-05
## ASV1060      2.277398e-04  2.385152e-04  2.497981e-04  2.616120e-04
## ASV0239     -5.020900e-04 -5.241206e-04 -5.470311e-04 -5.708490e-04
## ASV5711     -4.634863e-04 -4.840539e-04 -5.054700e-04 -5.277641e-04
## ASV4152     -6.170302e-04 -6.450171e-04 -6.742131e-04 -7.046654e-04
## ASV1461      5.454509e-04  5.695562e-04  5.946400e-04  6.207343e-04
## ASV2877      4.492171e-04  4.696628e-04  4.909937e-04  5.132440e-04
## ASV0012      3.430792e-04  3.595292e-04  3.767712e-04  3.948437e-04
## ASV9823      1.196727e-04  1.248060e-04  1.301321e-04  1.356556e-04
## ASV0008      3.737985e-04  3.915799e-04  4.102054e-04  4.297147e-04
## ASV7832     -3.783938e-04 -3.953800e-04 -4.130858e-04 -4.315380e-04
## ASV1915      3.346562e-05  3.544650e-05  3.755301e-05  3.979333e-05
## ASV0055      2.624131e-04  2.744570e-04  2.870322e-04  3.001602e-04
## ASV0032      6.306003e-04  6.589640e-04  6.885281e-04  7.193368e-04
## ASV2977     -5.194967e-04 -5.430427e-04 -5.676042e-04 -5.932208e-04
## ASV0466      5.231038e-04  5.463522e-04  5.705591e-04  5.957574e-04
## ASV3866      5.602942e-04  5.864789e-04  6.138636e-04  6.425010e-04
## ASV0040      7.473835e-04  7.826478e-04  8.195595e-04  8.581937e-04
## ASV0496     -4.620126e-05 -4.921279e-05 -5.243965e-05 -5.589811e-05
## ASV0052      9.000103e-04  9.410760e-04  9.839327e-04  1.028651e-03
## ASV3828     -5.522295e-04 -5.771660e-04 -6.031714e-04 -6.302871e-04
## ASV1930      3.473052e-04  3.633701e-04  3.801533e-04  3.976843e-04
## ASV2126      5.629466e-04  5.887498e-04  6.156884e-04  6.438079e-04
## ASV0793      3.459072e-04  3.628192e-04  3.805735e-04  3.992132e-04
## ASV0299     -2.297325e-04 -2.393955e-04 -2.494070e-04 -2.597743e-04
## ASV0208      5.316257e-04  5.569520e-04  5.834841e-04  6.112790e-04
## ASV0511     -2.782277e-04 -2.898818e-04 -3.019468e-04 -3.144299e-04
## ASV1123     -3.709184e-04 -3.870894e-04 -4.038971e-04 -4.213605e-04
## ASV0099     -2.058064e-04 -2.150497e-04 -2.246795e-04 -2.347091e-04
## ASV0752     -4.591467e-05 -4.847228e-05 -5.118193e-05 -5.405302e-05
## ASV0883      7.524026e-06  8.143130e-06  8.813841e-06  9.540331e-06
## ASV0683      4.745268e-04  4.970756e-04  5.206911e-04  5.454231e-04
## ASV4117     -5.562841e-04 -5.814633e-04 -6.077269e-04 -6.351172e-04
## ASV2172      2.095012e-04  2.192272e-04  2.293923e-04  2.400151e-04
## ASV0330     -3.806806e-04 -3.983827e-04 -4.168872e-04 -4.362286e-04
## ASV0728      3.647329e-04  3.821558e-04  4.004085e-04  4.195300e-04
## ASV0499      7.160024e-04  7.500248e-04  7.856595e-04  8.229825e-04
## ASV0120     -7.874130e-04 -8.236636e-04 -8.615234e-04 -9.010584e-04
## ASV1446      6.047026e-05  6.256656e-05  6.469402e-05  6.684843e-05
## ASV17171    -5.290574e-04 -5.531035e-04 -5.781946e-04 -6.043722e-04
## ASV0533      1.528527e-04  1.602311e-04  1.679697e-04  1.760862e-04
## ASV2495     -2.168475e-04 -2.270883e-04 -2.378122e-04 -2.490423e-04
## ASV5582      1.837104e-04  1.915764e-04  1.997375e-04  2.082007e-04
## ASV1488      1.731351e-04  1.814263e-04  1.901149e-04  1.992199e-04
## ASV0682      4.984034e-04  5.220700e-04  5.468562e-04  5.728145e-04
## ASV0068     -3.438728e-05 -3.666208e-05 -3.910073e-05 -4.171554e-05
## ASV1987     -2.734845e-04 -2.869692e-04 -3.011346e-04 -3.160160e-04
## ASV0035      8.565599e-05  8.846543e-05  9.129211e-05  9.412649e-05
## ASV7192     -3.532170e-04 -3.687942e-04 -3.850034e-04 -4.018655e-04
## ASV0873      4.850828e-05  5.013308e-05  5.177731e-05  5.343741e-05
## ASV4749      2.283640e-05  2.280647e-05  2.267473e-05  2.242774e-05
## ASV2174      3.346203e-04  3.492006e-04  3.643549e-04  3.801005e-04
## ASV1476     -2.959280e-04 -3.096479e-04 -3.239902e-04 -3.389822e-04
## ASV0740     -7.246106e-04 -7.589117e-04 -7.948252e-04 -8.324257e-04
## ASV0170      1.529682e-04  1.600303e-04  1.674092e-04  1.751181e-04
## ASV2466     -6.523803e-04 -6.823553e-04 -7.136622e-04 -7.463562e-04
## ASV1709      5.048931e-04  5.278530e-04  5.518100e-04  5.768034e-04
## ASV6170     -4.680420e-04 -4.899085e-04 -5.127767e-04 -5.366907e-04
## ASV3673      5.359640e-04  5.610376e-04  5.872630e-04  6.146912e-04
## ASV1745      4.133194e-05  4.328948e-05  4.533862e-05  4.748349e-05
##                                                                    
## (Intercept) -1.303326e-05 -1.484053e-05 -1.689092e-05 -1.921574e-05
## ASV1236      4.530227e-04  4.730762e-04  4.939491e-04  5.156692e-04
## ASV0421     -8.078011e-04 -8.438235e-04 -8.813413e-04 -9.204069e-04
## ASV0691     -6.955060e-04 -7.255251e-04 -7.567019e-04 -7.890691e-04
## ASV0899     -4.912804e-06 -4.490741e-06 -3.995957e-06 -3.421368e-06
## ASV1004      9.184697e-04  9.594661e-04  1.002167e-03  1.046631e-03
## ASV1041     -6.220167e-04 -6.498108e-04 -6.787611e-04 -7.089078e-04
## ASV1058      8.539060e-04  8.920486e-04  9.317814e-04  9.731611e-04
## ASV12542     2.584397e-04  2.695105e-04  2.810005e-04  2.929209e-04
## ASV1294      9.966440e-04  1.041632e-03  1.088537e-03  1.137433e-03
## ASV13113     3.654711e-04  3.829033e-04  4.011680e-04  4.203050e-04
## ASV1318      8.659989e-04  9.047241e-04  9.450661e-04  9.870822e-04
## ASV2269     -2.582504e-04 -2.698282e-04 -2.818907e-04 -2.944549e-04
## ASV2542      5.672909e-04  5.939428e-04  6.218289e-04  6.510046e-04
## ASV2660     -4.967443e-04 -5.186343e-04 -5.414082e-04 -5.650943e-04
## ASV2737     -2.876589e-05 -3.038382e-05 -3.209777e-05 -3.391353e-05
## ASV2840      6.594953e-04  6.883531e-04  7.183569e-04  7.495418e-04
## ASV3053      3.490845e-05  3.633769e-05  3.781615e-05  3.934483e-05
## ASV3077      2.058641e-04  2.149438e-04  2.243927e-04  2.342231e-04
## ASV3134      7.344167e-04  7.692397e-04  8.057070e-04  8.438954e-04
## ASV3140      3.208099e-04  3.358132e-04  3.515027e-04  3.679082e-04
## ASV3579      1.345596e-04  1.415110e-04  1.488422e-04  1.565754e-04
## ASV6119     -2.581667e-04 -2.697370e-04 -2.817913e-04 -2.943467e-04
## ASV7557     -2.581233e-04 -2.696896e-04 -2.817395e-04 -2.942902e-04
## ASV8422      1.412122e-04  1.472762e-04  1.535725e-04  1.601078e-04
## ASV1086     -7.076772e-05 -7.378959e-05 -7.692613e-05 -8.018056e-05
## ASV1310      4.935612e-04  5.158885e-04  5.391709e-04  5.634442e-04
## ASV15750    -1.214111e-04 -1.267410e-04 -1.322827e-04 -1.380422e-04
## ASV16905    -2.581063e-04 -2.696711e-04 -2.817193e-04 -2.942680e-04
## ASV2033      4.967195e-04  5.202188e-04  5.448207e-04  5.705760e-04
## ASV2089      1.771219e-04  1.851008e-04  1.934166e-04  2.020815e-04
## ASV2127      7.070527e-04  7.387849e-04  7.718536e-04  8.063073e-04
## ASV2725      7.942183e-04  8.291337e-04  8.654529e-04  9.032207e-04
## ASV2804     -2.580969e-04 -2.696609e-04 -2.817084e-04 -2.942564e-04
## ASV3075      5.097600e-04  5.329091e-04  5.570627e-04  5.822604e-04
## ASV3327      4.837381e-04  5.064550e-04  5.302241e-04  5.550925e-04
## ASV3342      5.241151e-04  5.484005e-04  5.737792e-04  6.002976e-04
## ASV3532     -4.725708e-04 -4.944326e-04 -5.172763e-04 -5.411434e-04
## ASV3600      5.982106e-04  6.257724e-04  6.545635e-04  6.846351e-04
## ASV4013      4.988735e-04  5.213691e-04  5.448221e-04  5.692682e-04
## ASV4136      4.915419e-04  5.133158e-04  5.359812e-04  5.595685e-04
## ASV4195      2.580355e-04  2.695939e-04  2.816354e-04  2.941769e-04
## ASV4407     -2.579920e-04 -2.695465e-04 -2.815837e-04 -2.941205e-04
## ASV4717      1.195833e-05  1.219181e-05  1.240945e-05  1.260861e-05
## ASV6794      2.628194e-04  2.741437e-04  2.859052e-04  2.981166e-04
## ASV8324     -2.579788e-04 -2.695319e-04 -2.815676e-04 -2.941027e-04
## ASV8981     -6.550564e-05 -6.799450e-05 -7.054414e-05 -7.315241e-05
## ASV9859      2.067277e-04  2.170204e-04  2.278445e-04  2.392289e-04
## ASV0936     -4.061797e-04 -4.244824e-04 -4.435635e-04 -4.634521e-04
## ASV12683    -4.372900e-05 -4.593797e-05 -4.826076e-05 -5.070318e-05
## ASV1293      5.968945e-04  6.234733e-04  6.511515e-04  6.799672e-04
## ASV13055    -6.159642e-05 -6.419491e-05 -6.688580e-05 -6.967069e-05
## ASV17063    -2.579072e-04 -2.694542e-04 -2.814833e-04 -2.940113e-04
## ASV2228      2.578638e-04  2.694069e-04  2.814316e-04  2.939549e-04
## ASV2769     -4.416531e-05 -4.573100e-05 -4.732329e-05 -4.893943e-05
## ASV2803      1.205272e-04  1.256297e-04  1.309208e-04  1.364053e-04
## ASV2896      3.283355e-04  3.435010e-04  3.593498e-04  3.759115e-04
## ASV3062      1.055448e-04  1.110172e-04  1.167904e-04  1.228820e-04
## ASV3107      3.954811e-04  4.137336e-04  4.328035e-04  4.527253e-04
## ASV3265      7.758514e-04  8.103458e-04  8.462622e-04  8.836494e-04
## ASV3666     -1.849756e-05 -1.942601e-05 -2.040251e-05 -2.142963e-05
## ASV4497      1.840740e-04  1.922902e-04  2.008490e-04  2.097629e-04
## ASV6914     -9.177664e-05 -9.604859e-05 -1.005134e-04 -1.051790e-04
## ASV0576     -9.088037e-04 -9.483404e-04 -9.894307e-04 -1.032121e-03
## ASV0673      2.456626e-04  2.575224e-04  2.699559e-04  2.829906e-04
## ASV0772      2.799163e-04  2.926573e-04  3.059534e-04  3.198268e-04
## ASV0862     -2.185329e-04 -2.277479e-04 -2.372963e-04 -2.471851e-04
## ASV0898      2.373474e-04  2.488626e-04  2.609416e-04  2.736122e-04
## ASV0910      5.093971e-04  5.336803e-04  5.591191e-04  5.857682e-04
## ASV0964     -3.302043e-04 -3.446965e-04 -3.597687e-04 -3.754392e-04
## ASV10059     2.391299e-04  2.506374e-04  2.627039e-04  2.753571e-04
## ASV10263    -2.581033e-04 -2.696687e-04 -2.817177e-04 -2.942676e-04
## ASV1088      2.711302e-04  2.841280e-04  2.977538e-04  3.120384e-04
## ASV1101      4.509333e-04  4.714105e-04  4.927692e-04  5.150428e-04
## ASV1183      2.899984e-04  3.033606e-04  3.173164e-04  3.318902e-04
## ASV11956     1.086177e-04  1.130876e-04  1.177107e-04  1.224897e-04
## ASV12774    -4.069904e-05 -4.273255e-05 -4.486974e-05 -4.711590e-05
## ASV1321      1.222213e-04  1.286509e-04  1.354401e-04  1.426103e-04
## ASV13793    -2.580525e-04 -2.696131e-04 -2.816571e-04 -2.942014e-04
## ASV14482    -2.568665e-05 -2.707543e-05 -2.854201e-05 -3.009071e-05
## ASV15483     1.847942e-04  1.934101e-04  2.024202e-04  2.118418e-04
## ASV2062      1.147766e-03  1.200004e-03  1.254510e-03  1.311373e-03
## ASV2132      5.277581e-04  5.523897e-04  5.781483e-04  6.050836e-04
## ASV2413      7.371527e-04  7.701294e-04  8.044874e-04  8.402766e-04
## ASV2490      4.818232e-04  5.029841e-04  5.249939e-04  5.478797e-04
## ASV2594      2.686215e-04  2.809050e-04  2.937316e-04  3.071239e-04
## ASV2822     -2.581265e-04 -2.696942e-04 -2.817459e-04 -2.942987e-04
## ASV2863      4.488120e-04  4.687286e-04  4.894633e-04  5.110443e-04
## ASV2910      5.846607e-04  6.105346e-04  6.374656e-04  6.654895e-04
## ASV2980      2.120780e-04  2.214907e-04  2.312883e-04  2.414835e-04
## ASV3307      2.580541e-04  2.696152e-04  2.816597e-04  2.942047e-04
## ASV3474      4.158908e-04  4.357901e-04  4.566431e-04  4.784955e-04
## ASV3502      8.489370e-04  8.877200e-04  9.282011e-04  9.704483e-04
## ASV4236      4.240260e-04  4.426565e-04  4.620349e-04  4.821849e-04
## ASV4842     -1.417476e-04 -1.481927e-04 -1.549146e-04 -1.619236e-04
## ASV4894     -2.581066e-04 -2.696728e-04 -2.817228e-04 -2.942739e-04
## ASV5290      3.208043e-04  3.354779e-04  3.507947e-04  3.667803e-04
## ASV5501      5.987601e-05  6.259429e-05  6.543195e-05  6.839403e-05
## ASV5795      2.187870e-04  2.290965e-04  2.398866e-04  2.511793e-04
## ASV5987     -2.581254e-04 -2.696936e-04 -2.817457e-04 -2.942991e-04
## ASV6267     -2.580820e-04 -2.696461e-04 -2.816940e-04 -2.942427e-04
## ASV6862      4.926364e-04  5.140171e-04  5.362338e-04  5.593116e-04
## ASV7145      8.946297e-05  9.323173e-05  9.713976e-05  1.011908e-04
## ASV7673     -2.580694e-04 -2.696323e-04 -2.816787e-04 -2.942259e-04
## ASV7789      1.007700e-04  1.060888e-04  1.117080e-04  1.176461e-04
## ASV7809     -2.844718e-05 -2.931588e-05 -3.018218e-05 -3.104227e-05
## ASV8002     -2.580397e-04 -2.696002e-04 -2.816442e-04 -2.941887e-04
## ASV8205      1.517729e-04  1.587340e-04  1.660044e-04  1.735974e-04
## ASV9155     -1.938934e-04 -2.025252e-04 -2.115124e-04 -2.208671e-04
## ASV9221     -2.549511e-05 -2.616252e-05 -2.681177e-05 -2.743768e-05
## ASV9311     -2.579831e-04 -2.695386e-04 -2.815773e-04 -2.941160e-04
## ASV9557     -2.579397e-04 -2.694912e-04 -2.815255e-04 -2.940595e-04
## ASV9936     -2.578963e-04 -2.694439e-04 -2.814738e-04 -2.940031e-04
## ASV1445      6.053181e-04  6.334468e-04  6.628512e-04  6.935864e-04
## ASV4232      5.157523e-04  5.402265e-04  5.658599e-04  5.927073e-04
## ASV6479      4.558364e-06  5.563390e-06  6.686172e-06  7.938153e-06
## ASV0142     -1.300442e-03 -1.357900e-03 -1.417697e-03 -1.479910e-03
## ASV0378     -4.230442e-04 -4.413391e-04 -4.603386e-04 -4.800619e-04
## ASV1122      8.003002e-04  8.375195e-04  8.764276e-04  9.170974e-04
## ASV0123     -1.273486e-03 -1.329697e-03 -1.388190e-03 -1.449041e-03
## ASV2064      1.291719e-04  1.345412e-04  1.400984e-04  1.458469e-04
## ASV4459     -1.409451e-04 -1.471884e-04 -1.536861e-04 -1.604465e-04
## ASV0448      2.367531e-04  2.487260e-04  2.613283e-04  2.745945e-04
## ASV0397      5.957602e-04  6.231871e-04  6.518329e-04  6.817479e-04
## ASV0485      8.293037e-04  8.669537e-04  9.062320e-04  9.472021e-04
## ASV1566      6.974601e-04  7.294989e-04  7.629548e-04  7.978855e-04
## ASV1365      4.526106e-04  4.734837e-04  4.952882e-04  5.180627e-04
## ASV1065      9.262972e-04  9.689335e-04  1.013464e-03  1.059967e-03
## ASV0722     -1.767723e-05 -1.830702e-05 -1.894991e-05 -1.960535e-05
## ASV12660    -4.273795e-04 -4.461492e-04 -4.656734e-04 -4.859764e-04
## ASV0223     -1.649817e-05 -1.715421e-05 -1.782907e-05 -1.852243e-05
## ASV0229      4.171226e-04  4.366725e-04  4.571242e-04  4.785178e-04
## ASV0877     -1.529954e-04 -1.594148e-04 -1.660633e-04 -1.729458e-04
## ASV0983      8.443452e-04  8.823950e-04  9.220617e-04  9.634054e-04
## ASV0626     -2.677293e-04 -2.786326e-04 -2.898934e-04 -3.015157e-04
## ASV4146     -4.563969e-05 -4.761132e-05 -4.965882e-05 -5.178433e-05
## ASV4175     -5.212102e-04 -5.451228e-04 -5.700897e-04 -5.961535e-04
## ASV2082     -4.277076e-05 -4.532573e-05 -4.805130e-05 -5.096005e-05
## ASV2272      3.791828e-04  3.969124e-04  4.154571e-04  4.348535e-04
## ASV2245     -4.552923e-04 -4.763422e-04 -4.983346e-04 -5.213090e-04
## ASV0590     -2.847136e-04 -2.987816e-04 -3.135630e-04 -3.290953e-04
## ASV0217     -3.985238e-04 -4.141369e-04 -4.301981e-04 -4.467046e-04
## ASV0416      4.120215e-04  4.295723e-04  4.477765e-04  4.666502e-04
## ASV1056      5.124828e-04  5.370535e-04  5.628048e-04  5.897930e-04
## ASV7777     -4.502622e-04 -4.709667e-04 -4.925894e-04 -5.151680e-04
## ASV0455      9.355725e-05  9.817796e-05  1.030302e-04  1.081256e-04
## ASV0604      1.060122e-04  1.117683e-04  1.178586e-04  1.243038e-04
## ASV6100     -4.164122e-04 -4.356309e-04 -4.557087e-04 -4.766813e-04
## ASV11359    -4.639026e-04 -4.850473e-04 -5.071115e-04 -5.301314e-04
## ASV6604      3.334779e-04  3.491795e-04  3.656122e-04  3.828093e-04
## ASV5004     -2.720067e-04 -2.843785e-04 -2.972862e-04 -3.107506e-04
## ASV1483     -2.516319e-04 -2.631586e-04 -2.751919e-04 -2.877522e-04
## ASV9773     -5.329075e-04 -5.574344e-04 -5.830511e-04 -6.098026e-04
## ASV4059      5.540247e-05  5.849127e-05  6.176713e-05  6.524228e-05
## ASV1193      8.662112e-04  9.059173e-04  9.473725e-04  9.906475e-04
## ASV4610     -6.709952e-05 -6.915370e-05 -7.120930e-05 -7.325897e-05
## ASV0742     -3.114654e-04 -3.242473e-04 -3.374576e-04 -3.511017e-04
## ASV1502     -9.040516e-06 -9.929177e-06 -1.089977e-05 -1.195937e-05
## ASV0195     -1.007023e-04 -1.059280e-04 -1.114373e-04 -1.172460e-04
## ASV1213      2.681264e-04  2.796638e-04  2.916405e-04  3.040682e-04
## ASV1648     -3.937968e-04 -4.118489e-04 -4.306970e-04 -4.503735e-04
## ASV6984     -2.957942e-04 -3.094783e-04 -3.237775e-04 -3.387176e-04
## ASV0396     -2.049576e-04 -2.122961e-04 -2.197733e-04 -2.273786e-04
## ASV4297      4.381918e-04  4.574814e-04  4.775501e-04  4.984231e-04
## ASV2622      1.002129e-03  1.046794e-03  1.093313e-03  1.141751e-03
## ASV3512      1.631472e-04  1.715270e-04  1.803611e-04  1.896760e-04
## ASV2411      3.533112e-04  3.701598e-04  3.878105e-04  4.063012e-04
## ASV2291     -9.310225e-05 -9.794209e-05 -1.030490e-04 -1.084389e-04
## ASV0807      4.201700e-04  4.408684e-04  4.626090e-04  4.854454e-04
## ASV1292      2.261014e-04  2.361793e-04  2.466769e-04  2.576090e-04
## ASV1035      1.034181e-04  1.077431e-04  1.122241e-04  1.168647e-04
## ASV0070     -2.296412e-04 -2.389083e-04 -2.484666e-04 -2.583170e-04
## ASV0255      9.793108e-05  1.024063e-04  1.070756e-04  1.119463e-04
## ASV0057     -1.025599e-03 -1.070264e-03 -1.116683e-03 -1.164909e-03
## ASV0077     -1.431962e-04 -1.486349e-04 -1.542096e-04 -1.599164e-04
## ASV0625      1.026666e-03  1.072086e-03  1.119359e-03  1.168546e-03
## ASV2464      4.939323e-04  5.154142e-04  5.377421e-04  5.609420e-04
## ASV1315      9.172656e-04  9.606557e-04  1.006082e-03  1.053638e-03
## ASV2673      6.697827e-04  7.017264e-04  7.351942e-04  7.702588e-04
## ASV2161      2.765725e-04  2.898417e-04  3.037513e-04  3.183325e-04
## ASV0337     -4.332633e-04 -4.528851e-04 -4.733491e-04 -4.946872e-04
## ASV7680     -5.130036e-04 -5.367034e-04 -5.614642e-04 -5.873305e-04
## ASV0611      1.122265e-03  1.174848e-03  1.229856e-03  1.287398e-03
## ASV3118     -3.807263e-04 -3.984936e-04 -4.170722e-04 -4.364972e-04
## ASV1284      4.016417e-04  4.203541e-04  4.399191e-04  4.603738e-04
## ASV0889      3.022159e-04  3.158565e-04  3.300810e-04  3.449117e-04
## ASV4649     -3.175728e-04 -3.321394e-04 -3.473481e-04 -3.632251e-04
## ASV1108     -4.134473e-04 -4.332767e-04 -4.540611e-04 -4.758464e-04
## ASV0738     -4.460884e-05 -4.460129e-05 -4.440596e-05 -4.399844e-05
## ASV0473      6.295784e-05  6.589879e-05  6.897587e-05  7.219535e-05
## ASV0598     -4.505776e-04 -4.700269e-04 -4.902246e-04 -5.111915e-04
## ASV0429      7.318190e-04  7.649214e-04  7.994402e-04  8.354288e-04
## ASV1549      7.473117e-04  7.830965e-04  8.206004e-04  8.599063e-04
## ASV1203      5.544597e-04  5.797124e-04  6.060625e-04  6.335530e-04
## ASV4532      2.210283e-05  2.283769e-05  2.358257e-05  2.433631e-05
## ASV0274     -5.467677e-04 -5.704832e-04 -5.951228e-04 -6.207134e-04
## ASV0163     -7.793804e-04 -8.130141e-04 -8.479415e-04 -8.841985e-04
## ASV1298      3.166140e-04  3.302782e-04  3.444698e-04  3.592040e-04
## ASV9424     -6.822030e-04 -7.139487e-04 -7.471376e-04 -7.818320e-04
## ASV0412      1.040923e-03  1.088109e-03  1.137329e-03  1.188663e-03
## ASV0284      4.593206e-04  4.793875e-04  5.002509e-04  5.219355e-04
## ASV0620     -3.559304e-04 -3.730544e-04 -3.910058e-04 -4.098245e-04
## ASV0153     -7.349466e-04 -7.696214e-04 -8.059147e-04 -8.439004e-04
## ASV0498      9.223321e-05  9.801450e-05  1.041890e-04  1.107846e-04
## ASV0097      5.281040e-04  5.532322e-04  5.795550e-04  6.071288e-04
## ASV0104     -2.401035e-03 -2.510656e-03 -2.625068e-03 -2.744461e-03
## ASV1282      4.207550e-04  4.403126e-04  4.607561e-04  4.821232e-04
## ASV3883     -2.468153e-04 -2.586017e-04 -2.709495e-04 -2.838852e-04
## ASV0801      2.483300e-04  2.605059e-04  2.732881e-04  2.867069e-04
## ASV1611     -9.311427e-04 -9.744687e-04 -1.019764e-03 -1.067113e-03
## ASV0227     -3.454704e-04 -3.624505e-04 -3.802819e-04 -3.990080e-04
## ASV0833      3.708299e-04  3.890144e-04  4.081058e-04  4.281498e-04
## ASV0718      8.636834e-04  9.034685e-04  9.450260e-04  9.884294e-04
## ASV1139      3.057713e-04  3.185546e-04  3.317868e-04  3.454756e-04
## ASV0766     -2.325219e-04 -2.428354e-04 -2.535709e-04 -2.647426e-04
## ASV2091      1.140762e-03  1.191077e-03  1.243432e-03  1.297893e-03
## ASV1238     -6.444244e-05 -6.632643e-05 -6.819592e-05 -7.004164e-05
## ASV9193     -1.114732e-04 -1.174963e-04 -1.238670e-04 -1.306064e-04
## ASV0290     -1.017585e-04 -1.070478e-04 -1.126245e-04 -1.185048e-04
## ASV0231      9.122897e-04  9.538313e-04  9.971800e-04  1.042407e-03
## ASV0185      1.890720e-04  2.009369e-04  2.136201e-04  2.271817e-04
## ASV2330      2.610693e-04  2.726569e-04  2.847210e-04  2.972779e-04
## ASV3119     -3.109942e-04 -3.265930e-04 -3.430025e-04 -3.602669e-04
## ASV2368     -4.224277e-04 -4.425026e-04 -4.635293e-04 -4.855525e-04
## ASV0122     -3.229753e-04 -3.370606e-04 -3.517027e-04 -3.669188e-04
## ASV1044      5.844432e-04  6.127617e-04  6.424684e-04  6.736322e-04
## ASV0160     -7.932966e-04 -8.274531e-04 -8.629142e-04 -8.997151e-04
## ASV0326      5.262124e-04  5.504678e-04  5.758038e-04  6.022654e-04
## ASV1388      9.189336e-04  9.609318e-04  1.004769e-03  1.050519e-03
## ASV0792      1.035512e-03  1.082075e-03  1.130606e-03  1.181178e-03
## ASV0036     -6.636393e-04 -6.947462e-04 -7.272860e-04 -7.613224e-04
## ASV2125      1.074126e-03  1.123179e-03  1.174377e-03  1.227805e-03
## ASV1075      2.087340e-04  2.187221e-04  2.291897e-04  2.401600e-04
## ASV0390      2.098889e-04  2.205899e-04  2.318635e-04  2.437425e-04
## ASV3790     -8.679543e-04 -9.082366e-04 -9.503395e-04 -9.943408e-04
## ASV1535     -7.403888e-05 -7.788054e-05 -8.193400e-05 -8.621186e-05
## ASV0263      1.789464e-04  1.872126e-04  1.958486e-04  2.048698e-04
## ASV0675      1.435852e-03  1.503788e-03  1.574914e-03  1.649376e-03
## ASV3348      1.402837e-04  1.472411e-04  1.545546e-04  1.622432e-04
## ASV0058     -1.352149e-03 -1.413578e-03 -1.477662e-03 -1.544503e-03
## ASV4142      3.384227e-04  3.537020e-04  3.696301e-04  3.862308e-04
## ASV0059     -1.164861e-03 -1.217628e-03 -1.272661e-03 -1.330046e-03
## ASV0013     -2.436994e-03 -2.548234e-03 -2.664335e-03 -2.785490e-03
## ASV0033     -7.232433e-04 -7.572369e-04 -7.928055e-04 -8.300199e-04
## ASV4354     -3.088839e-04 -3.225905e-04 -3.368633e-04 -3.517222e-04
## ASV0022     -7.623954e-04 -7.981376e-04 -8.355270e-04 -8.746366e-04
## ASV0134     -1.929234e-04 -2.024312e-04 -2.124173e-04 -2.229063e-04
## ASV0415     -1.481733e-04 -1.537057e-04 -1.593703e-04 -1.651629e-04
## ASV10103    -5.316720e-04 -5.563595e-04 -5.821636e-04 -6.091319e-04
## ASV1613      8.501140e-04  8.882881e-04  9.280711e-04  9.695214e-04
## ASV0135     -3.319537e-05 -3.310984e-05 -3.287155e-05 -3.246066e-05
## ASV0469     -1.059170e-03 -1.106560e-03 -1.155934e-03 -1.207363e-03
## ASV0471      6.799890e-04  7.113484e-04  7.441059e-04  7.783193e-04
## ASV0451     -1.913342e-04 -2.008603e-04 -2.108758e-04 -2.214066e-04
## ASV0747      2.705752e-04  2.838482e-04  2.977846e-04  3.124180e-04
## ASV1314     -4.125345e-04 -4.325634e-04 -4.535801e-04 -4.756345e-04
## ASV0425     -1.195643e-03 -1.248229e-03 -1.302931e-03 -1.359817e-03
## ASV0559     -6.799563e-04 -7.098470e-04 -7.409445e-04 -7.732888e-04
## ASV0148     -7.358938e-04 -7.680195e-04 -8.014135e-04 -8.361139e-04
## ASV0129     -3.580626e-04 -3.727185e-04 -3.878583e-04 -4.034872e-04
## ASV1072      3.560391e-04  3.714199e-04  3.873920e-04  4.039713e-04
## ASV2390      2.539397e-04  2.649107e-04  2.763026e-04  2.881267e-04
## ASV0548      7.848282e-04  8.211975e-04  8.592064e-04  8.989244e-04
## ASV0168     -1.170309e-03 -1.222984e-03 -1.277894e-03 -1.335122e-03
## ASV0066     -8.700518e-04 -9.095086e-04 -9.506647e-04 -9.935853e-04
## ASV0468     -3.226715e-04 -3.374819e-04 -3.529472e-04 -3.690943e-04
## ASV0172     -1.700922e-04 -1.762156e-04 -1.824561e-04 -1.888045e-04
## ASV0236     -4.358756e-04 -4.535360e-04 -4.717632e-04 -4.905613e-04
## ASV0250      4.343911e-05  4.803778e-05  5.307943e-05  5.860388e-05
## ASV0338     -5.318736e-05 -5.423287e-05 -5.520191e-05 -5.608106e-05
## ASV0450     -3.901908e-06 -4.052372e-06 -4.206727e-06 -4.364882e-06
## ASV0377      9.587455e-04  1.002633e-03  1.048450e-03  1.096274e-03
## ASV1022      2.679069e-04  2.803107e-04  2.932738e-04  3.068202e-04
## ASV6174     -6.488256e-05 -6.772595e-05 -7.068473e-05 -7.376298e-05
## ASV0786      1.042550e-04  1.086381e-04  1.131798e-04  1.178835e-04
## ASV0053     -1.155019e-03 -1.208088e-03 -1.263507e-03 -1.321372e-03
## ASV0697     -3.269808e-04 -3.410381e-04 -3.556316e-04 -3.707757e-04
## ASV0785      8.592712e-04  8.986712e-04  9.398089e-04  9.827547e-04
## ASV1967     -5.590980e-04 -5.836456e-04 -6.091816e-04 -6.357386e-04
## ASV0385     -2.584338e-04 -2.694173e-04 -2.808075e-04 -2.926144e-04
## ASV0295      1.307540e-05  1.506496e-05  1.727122e-05  1.971480e-05
## ASV0072     -9.093279e-04 -9.494674e-04 -9.912333e-04 -1.034678e-03
## ASV0157     -3.723742e-04 -3.881234e-04 -4.044429e-04 -4.213442e-04
## ASV0501      4.277009e-04  4.483154e-04  4.699317e-04  4.925992e-04
## ASV10729    -7.060275e-04 -7.387733e-04 -7.729963e-04 -8.087595e-04
## ASV1470      3.309488e-04  3.456794e-04  3.610186e-04  3.769874e-04
## ASV0050     -2.295063e-03 -2.399041e-03 -2.507489e-03 -2.620579e-03
## ASV0411     -5.462635e-05 -5.647899e-05 -5.835307e-05 -6.024396e-05
## ASV0549      4.441780e-04  4.654374e-04  4.877178e-04  5.110684e-04
## ASV0184      2.688486e-04  2.811664e-04  2.940291e-04  3.074593e-04
## ASV0705      3.274043e-04  3.428332e-04  3.589784e-04  3.758716e-04
## ASV1715      8.197124e-04  8.575286e-04  8.970346e-04  9.383011e-04
## ASV0603      9.899406e-05  1.037700e-04  1.087798e-04  1.140352e-04
## ASV0826      2.697654e-04  2.815794e-04  2.938638e-04  3.066334e-04
## ASV0034     -1.032899e-03 -1.079123e-03 -1.127278e-03 -1.177434e-03
## ASV0838      2.183229e-04  2.281450e-04  2.383804e-04  2.490439e-04
## ASV0614     -5.882162e-04 -6.147031e-04 -6.423145e-04 -6.710925e-04
## ASV0014     -2.225879e-03 -2.326874e-03 -2.432226e-03 -2.542104e-03
## ASV0585     -1.414999e-04 -1.481204e-04 -1.550447e-04 -1.622859e-04
## ASV0016     -2.276071e-03 -2.379418e-03 -2.487230e-03 -2.599680e-03
## ASV5394     -5.810198e-04 -6.078952e-04 -6.359762e-04 -6.653134e-04
## ASV0666      4.904509e-04  5.126804e-04  5.358661e-04  5.600446e-04
## ASV2085      1.814231e-04  1.881550e-04  1.950416e-04  2.020768e-04
## ASV0003     -2.079343e-03 -2.173441e-03 -2.271575e-03 -2.373901e-03
## ASV0346     -2.684239e-05 -2.646030e-05 -2.591630e-05 -2.519116e-05
## ASV0267     -3.226958e-04 -3.364553e-04 -3.507247e-04 -3.655156e-04
## ASV0353      4.583328e-04  4.809800e-04  5.047758e-04  5.297803e-04
## ASV2419      5.856975e-04  6.120192e-04  6.394544e-04  6.680441e-04
## ASV0447      2.939609e-04  3.092056e-04  3.252812e-04  3.422351e-04
## ASV0654      9.189712e-04  9.618115e-04  1.006603e-03  1.053429e-03
## ASV0151      1.511861e-04  1.592787e-04  1.678378e-04  1.768926e-04
## ASV0065     -8.406777e-04 -8.788848e-04 -9.187444e-04 -9.603204e-04
## ASV0527      6.089494e-04  6.366992e-04  6.656571e-04  6.958709e-04
## ASV4055     -2.325130e-04 -2.437132e-04 -2.554583e-04 -2.677752e-04
## ASV0166     -6.935002e-04 -7.241509e-04 -7.560501e-04 -7.892392e-04
## ASV0417     -5.894424e-04 -6.159548e-04 -6.435908e-04 -6.723921e-04
## ASV0078     -4.694216e-04 -4.900930e-04 -5.115955e-04 -5.339551e-04
## ASV0322     -5.711670e-04 -5.963203e-04 -6.224865e-04 -6.496980e-04
## ASV0156     -7.457683e-04 -7.791640e-04 -8.139622e-04 -8.502136e-04
## ASV0648     -6.840376e-04 -7.160063e-04 -7.494398e-04 -7.844025e-04
## ASV0407      5.605799e-05  5.909238e-05  6.230385e-05  6.570356e-05
## ASV2030     -1.400182e-04 -1.458346e-04 -1.518582e-04 -1.580936e-04
## ASV0300      4.083839e-04  4.283992e-04  4.494144e-04  4.714806e-04
## ASV1150     -4.759077e-05 -4.929043e-05 -5.101988e-05 -5.277612e-05
## ASV0958      4.262191e-04  4.471069e-04  4.690422e-04  4.920794e-04
## ASV0216     -7.046518e-04 -7.356462e-04 -7.678919e-04 -8.014300e-04
## ASV0446      1.009659e-03  1.057770e-03  1.108166e-03  1.160954e-03
## ASV0367     -3.398855e-04 -3.553212e-04 -3.714247e-04 -3.882223e-04
## ASV0200     -6.358744e-04 -6.650707e-04 -6.955602e-04 -7.273963e-04
## ASV0334     -3.122086e-04 -3.245253e-04 -3.372058e-04 -3.502494e-04
## ASV1311      4.454430e-04  4.654955e-04  4.863980e-04  5.081818e-04
## ASV0458      4.825638e-04  5.044677e-04  5.273205e-04  5.511596e-04
## ASV1371      1.532077e-05  1.609899e-05  1.691863e-05  1.778202e-05
## ASV0418      5.916978e-04  6.188544e-04  6.472128e-04  6.768225e-04
## ASV0004      7.011984e-04  7.332089e-04  7.666183e-04  8.014821e-04
## ASV1943      5.083047e-04  5.310322e-04  5.547144e-04  5.793864e-04
## ASV1495     -1.349108e-04 -1.421741e-04 -1.498573e-04 -1.579865e-04
## ASV0901     -8.076991e-04 -8.456866e-04 -8.854388e-04 -9.270357e-04
## ASV0628      4.625624e-04  4.831382e-04  5.045621e-04  5.268627e-04
## ASV0400      1.854774e-04  1.937462e-04  2.023570e-04  2.113213e-04
## ASV0116     -6.260943e-04 -6.560186e-04 -6.873748e-04 -7.202312e-04
## ASV0788      5.087196e-04  5.321504e-04  5.566245e-04  5.821852e-04
## ASV0117      3.347334e-04  3.510377e-04  3.681499e-04  3.861111e-04
## ASV3137      8.846205e-05  9.240237e-05  9.650624e-05  1.007794e-04
## ASV0001      8.304761e-04  8.670585e-04  9.051183e-04  9.447036e-04
## ASV1651      5.538924e-04  5.783029e-04  6.037026e-04  6.301242e-04
## ASV1692      6.094666e-04  6.385395e-04  6.689981e-04  7.009081e-04
## ASV0660      3.352862e-04  3.495404e-04  3.643183e-04  3.796314e-04
## ASV0508      3.881224e-05  4.017617e-05  4.156507e-05  4.297717e-05
## ASV1660     -2.525237e-04 -2.648218e-04 -2.777258e-04 -2.912656e-04
## ASV0233      1.407936e-04  1.476979e-04  1.549497e-04  1.625672e-04
## ASV1343     -6.071614e-04 -6.353677e-04 -6.648524e-04 -6.956706e-04
## ASV0209      5.495189e-04  5.735333e-04  5.985013e-04  6.244525e-04
## ASV0193     -7.197344e-04 -7.517578e-04 -7.851063e-04 -8.198262e-04
## ASV0357     -3.395024e-05 -3.447048e-05 -3.491622e-05 -3.527532e-05
## ASV0198      1.567839e-04  1.641087e-04  1.717692e-04  1.797803e-04
## ASV0007      7.872514e-04  8.219282e-04  8.580055e-04  8.955288e-04
## ASV1772     -8.088300e-05 -8.447701e-05 -8.821732e-05 -9.210851e-05
## ASV0009      7.418698e-04  7.744559e-04  8.083494e-04  8.435921e-04
## ASV0006      2.905461e-04  3.023727e-04  3.145851e-04  3.271869e-04
## ASV0011     -8.505787e-04 -8.903411e-04 -9.319274e-04 -9.754179e-04
## ASV0015      5.898717e-04  6.168512e-04  6.450133e-04  6.744054e-04
## ASV0017      6.239339e-04  6.523975e-04  6.821028e-04  7.130989e-04
## ASV0235     -4.962688e-04 -5.194084e-04 -5.436021e-04 -5.688954e-04
## ASV0382      1.004442e-04  1.064808e-04  1.129104e-04  1.197598e-04
## ASV2357      7.524296e-04  7.872687e-04  8.236768e-04  8.617209e-04
## ASV0567     -5.402340e-04 -5.645563e-04 -5.899143e-04 -6.163472e-04
## ASV0165      5.952740e-04  6.225261e-04  6.509768e-04  6.806745e-04
## ASV0005      1.191819e-03  1.245495e-03  1.301447e-03  1.359759e-03
## ASV0384     -4.901316e-05 -5.035003e-05 -5.165971e-05 -5.293295e-05
## ASV0002      2.629309e-04  2.756957e-04  2.890895e-04  3.031440e-04
## ASV3017      6.920848e-04  7.229173e-04  7.550274e-04  7.884596e-04
## ASV0091      2.724073e-04  2.852969e-04  2.987912e-04  3.129179e-04
## ASV0186     -7.250372e-04 -7.586373e-04 -7.937504e-04 -8.304407e-04
## ASV0370      7.546952e-05  7.916466e-05  8.304420e-05  8.711759e-05
## ASV0018      1.242913e-03  1.299069e-03  1.357623e-03  1.418666e-03
## ASV1377      1.083662e-03  1.132451e-03  1.183311e-03  1.236318e-03
## ASV0019      1.244686e-03  1.300941e-03  1.359602e-03  1.420758e-03
## ASV0023      7.421342e-05  7.615261e-05  7.804482e-05  7.987644e-05
## ASV2194      4.126806e-04  4.321683e-04  4.525690e-04  4.739248e-04
## ASV1155     -4.017521e-05 -4.131636e-05 -4.244084e-05 -4.354167e-05
## ASV0510     -4.448905e-04 -4.635664e-04 -4.829096e-04 -5.029336e-04
## ASV2371     -4.411908e-04 -4.602996e-04 -4.801550e-04 -5.007794e-04
## ASV0024      1.406729e-05  1.323985e-05  1.224261e-05  1.105692e-05
## ASV2452      5.788987e-04  6.043518e-04  6.308253e-04  6.583512e-04
## ASV2332      4.250541e-05  4.582671e-05  4.941368e-05  5.328699e-05
## ASV2591      3.977056e-05  4.296345e-05  4.641481e-05  5.014469e-05
## ASV0521      8.130480e-04  8.515112e-04  8.917802e-04  9.339382e-04
## ASV5542      2.549427e-04  2.673109e-04  2.802818e-04  2.938843e-04
## ASV0336     -3.755199e-04 -3.926041e-04 -4.104300e-04 -4.290266e-04
## ASV10102     5.617248e-04  5.879861e-04  6.154497e-04  6.441683e-04
## ASV16823    -4.256119e-04 -4.438586e-04 -4.628020e-04 -4.824618e-04
## ASV3104      4.255437e-04  4.437845e-04  4.627215e-04  4.823744e-04
## ASV0781      2.097104e-04  2.191295e-04  2.289450e-04  2.391711e-04
## ASV10899     2.158642e-04  2.270665e-04  2.388790e-04  2.513366e-04
## ASV11222    -4.255013e-04 -4.437388e-04 -4.626722e-04 -4.823213e-04
## ASV11327    -4.254332e-04 -4.436647e-04 -4.625917e-04 -4.822339e-04
## ASV12458    -4.253651e-04 -4.435906e-04 -4.625113e-04 -4.821465e-04
## ASV1636     -3.470888e-04 -3.618667e-04 -3.771972e-04 -3.930945e-04
## ASV1890     -4.263587e-04 -4.449099e-04 -4.641967e-04 -4.842425e-04
## ASV2898      9.349073e-04  9.768940e-04  1.020652e-03  1.066245e-03
## ASV8328     -5.816248e-05 -5.925117e-05 -6.024908e-05 -6.114076e-05
## ASV0709     -7.659762e-04 -8.005375e-04 -8.365691e-04 -8.741257e-04
## ASV0856      1.284775e-04  1.349298e-04  1.417165e-04  1.488556e-04
## ASV0909     -3.079827e-04 -3.201877e-04 -3.327580e-04 -3.456933e-04
## ASV0937     -6.038371e-04 -6.318009e-04 -6.610290e-04 -6.915762e-04
## ASV11390    -4.252218e-04 -4.434351e-04 -4.623425e-04 -4.819635e-04
## ASV11966     2.323577e-04  2.439128e-04  2.560563e-04  2.688188e-04
## ASV12990     1.205166e-04  1.261663e-04  1.320725e-04  1.382459e-04
## ASV14797     4.458204e-04  4.654935e-04  4.859631e-04  5.072553e-04
## ASV14904    -4.252065e-04 -4.434188e-04 -4.623253e-04 -4.819453e-04
## ASV15304     1.287525e-04  1.357131e-04  1.430726e-04  1.508548e-04
## ASV16696    -4.251532e-04 -4.433613e-04 -4.622631e-04 -4.818781e-04
## ASV1690      2.390585e-04  2.512026e-04  2.639834e-04  2.774348e-04
## ASV2029      1.204531e-03  1.259104e-03  1.316024e-03  1.375382e-03
## ASV2834      6.502164e-04  6.801932e-04  7.115091e-04  7.442203e-04
## ASV4003      2.008998e-04  2.116303e-04  2.229691e-04  2.349527e-04
## ASV4064      4.592929e-04  4.808980e-04  5.035026e-04  5.271509e-04
## ASV4294      1.682888e-04  1.771500e-04  1.865045e-04  1.963813e-04
## ASV4609     -1.441526e-05 -1.471984e-05 -1.500870e-05 -1.527896e-05
## ASV6283     -4.251561e-04 -4.433657e-04 -4.622694e-04 -4.818866e-04
## ASV6491     -4.250881e-04 -4.432917e-04 -4.621890e-04 -4.817993e-04
## ASV7453      1.852087e-04  1.949108e-04  2.051471e-04  2.159483e-04
## ASV7959      4.629486e-05  4.960685e-05  5.316839e-05  5.699822e-05
## ASV8219      4.250464e-04  4.432471e-04  4.621412e-04  4.817482e-04
## ASV8547     -4.249784e-04 -4.431731e-04 -4.620609e-04 -4.816609e-04
## ASV9319      3.013207e-04  3.156483e-04  3.306520e-04  3.463631e-04
## ASV9382     -4.249393e-04 -4.431309e-04 -4.620153e-04 -4.816118e-04
## ASV11516    -4.248713e-04 -4.430570e-04 -4.619350e-04 -4.815246e-04
## ASV14377    -4.248034e-04 -4.429832e-04 -4.618548e-04 -4.814374e-04
## ASV1867      6.472586e-04  6.775221e-04  7.091721e-04  7.422692e-04
## ASV1895     -1.437499e-04 -1.497890e-04 -1.560480e-04 -1.625323e-04
## ASV3168      2.698942e-04  2.818853e-04  2.943647e-04  3.073479e-04
## ASV4449      5.346553e-04  5.581206e-04  5.825336e-04  6.079262e-04
## ASV6596      3.259842e-04  3.422289e-04  3.593079e-04  3.772654e-04
## ASV7492     -1.483930e-04 -1.537232e-04 -1.591612e-04 -1.647008e-04
## ASV9854     -2.161683e-04 -2.251773e-04 -2.345088e-04 -2.441702e-04
## ASV6296      4.246663e-04  4.428349e-04  4.616944e-04  4.812641e-04
## ASV4201      1.612581e-04  1.703993e-04  1.800982e-04  1.903907e-04
## ASV0552      1.084275e-03  1.135112e-03  1.188293e-03  1.243921e-03
## ASV3671     -7.907469e-05 -8.163193e-05 -8.421213e-05 -8.680920e-05
## ASV3529     -8.171007e-05 -8.404589e-05 -8.636493e-05 -8.865695e-05
## ASV1060      2.739819e-04  2.869338e-04  3.004948e-04  3.146935e-04
## ASV0239     -5.956018e-04 -6.213171e-04 -6.480226e-04 -6.757458e-04
## ASV5711     -5.509665e-04 -5.751083e-04 -6.002209e-04 -6.263364e-04
## ASV4152     -7.364227e-04 -7.695351e-04 -8.040542e-04 -8.400330e-04
## ASV1461      6.478714e-04  6.760838e-04  7.054043e-04  7.358657e-04
## ASV2877      5.364488e-04  5.606440e-04  5.858665e-04  6.121541e-04
## ASV0012      4.137868e-04  4.336424e-04  4.544547e-04  4.762698e-04
## ASV9823      1.413810e-04  1.473126e-04  1.534544e-04  1.598102e-04
## ASV0008      4.501496e-04  4.715535e-04  4.939722e-04  5.174533e-04
## ASV7832     -4.507645e-04 -4.707939e-04 -4.916555e-04 -5.133793e-04
## ASV1915      4.217616e-05  4.471068e-05  4.740665e-05  5.027438e-05
## ASV0055      3.138631e-04  3.281637e-04  3.430856e-04  3.586530e-04
## ASV0032      7.514352e-04  7.848697e-04  8.196875e-04  8.559368e-04
## ASV2977     -6.199329e-04 -6.477826e-04 -6.768127e-04 -7.070676e-04
## ASV0466      6.219807e-04  6.492632e-04  6.776393e-04  7.071441e-04
## ASV3866      6.724459e-04  7.037554e-04  7.364890e-04  7.707082e-04
## ASV0040      8.986292e-04  9.409479e-04  9.852354e-04  1.031581e-03
## ASV0496     -5.960566e-05 -6.358110e-05 -6.784462e-05 -7.241792e-05
## ASV0052      1.075304e-03  1.123966e-03  1.174715e-03  1.227629e-03
## ASV3828     -6.585555e-04 -6.880203e-04 -7.187267e-04 -7.507209e-04
## ASV1930      4.159937e-04  4.351129e-04  4.550746e-04  4.759122e-04
## ASV2126      6.731555e-04  7.037797e-04  7.357305e-04  7.690594e-04
## ASV0793      4.187834e-04  4.393314e-04  4.609073e-04  4.835632e-04
## ASV0299     -2.705045e-04 -2.816045e-04 -2.930806e-04 -3.049387e-04
## ASV0208      6.403967e-04  6.708998e-04  7.028538e-04  7.363275e-04
## ASV0511     -3.273377e-04 -3.406759e-04 -3.544495e-04 -3.686627e-04
## ASV1123     -4.394988e-04 -4.583308e-04 -4.778756e-04 -4.981520e-04
## ASV0099     -2.451521e-04 -2.560220e-04 -2.673324e-04 -2.790971e-04
## ASV0752     -5.709553e-05 -6.032004e-05 -6.373772e-05 -6.736043e-05
## ASV0883      1.032709e-05  1.117892e-05  1.210099e-05  1.309884e-05
## ASV0683      5.713237e-04  5.984473e-04  6.268506e-04  6.565930e-04
## ASV4117     -6.636778e-04 -6.934535e-04 -7.244905e-04 -7.568365e-04
## ASV2172      2.511148e-04  2.627115e-04  2.748259e-04  2.874795e-04
## ASV0330     -4.564425e-04 -4.775660e-04 -4.996375e-04 -5.226967e-04
## ASV0728      4.395608e-04  4.605435e-04  4.825221e-04  5.055429e-04
## ASV0499      8.620731e-04  9.030146e-04  9.458938e-04  9.908016e-04
## ASV0120     -9.423364e-04 -9.854279e-04 -1.030405e-03 -1.077343e-03
## ASV1446      6.902499e-05  7.121821e-05  7.342187e-05  7.562893e-05
## ASV17171    -6.316791e-04 -6.601598e-04 -6.898600e-04 -7.208269e-04
## ASV0533      1.845996e-04  1.935295e-04  2.028967e-04  2.127229e-04
## ASV2495     -2.608026e-04 -2.731185e-04 -2.860168e-04 -2.995252e-04
## ASV5582      2.169732e-04  2.260617e-04  2.354727e-04  2.452124e-04
## ASV1488      2.087612e-04  2.187593e-04  2.292360e-04  2.402139e-04
## ASV0682      5.999998e-04  6.284695e-04  6.582835e-04  6.895046e-04
## ASV0068     -4.451971e-05 -4.752741e-05 -5.075383e-05 -5.421524e-05
## ASV1987     -3.316506e-04 -3.480774e-04 -3.653377e-04 -3.834748e-04
## ASV0035      9.695774e-05  9.977356e-05  1.025601e-04  1.053016e-04
## ASV7192     -4.194016e-04 -4.376333e-04 -4.565821e-04 -4.762700e-04
## ASV0873      5.510936e-05  5.678867e-05  5.847031e-05  6.014868e-05
## ASV4749      2.205078e-05  2.152767e-05  2.084074e-05  1.997065e-05
## ASV2174      3.964547e-04  4.134347e-04  4.310579e-04  4.493415e-04
## ASV1476     -3.546524e-04 -3.710305e-04 -3.881474e-04 -4.060352e-04
## ASV0740     -8.717910e-04 -9.130025e-04 -9.561451e-04 -1.001307e-03
## ASV0170      1.831713e-04  1.915830e-04  2.003684e-04  2.095431e-04
## ASV2466     -7.804950e-04 -8.161383e-04 -8.533478e-04 -8.921876e-04
## ASV1709      6.028738e-04  6.300629e-04  6.584140e-04  6.879712e-04
## ASV6170     -5.616965e-04 -5.878416e-04 -6.151756e-04 -6.437502e-04
## ASV3673      6.433753e-04  6.733705e-04  7.047342e-04  7.375260e-04
## ASV1745      4.972838e-05  5.207777e-05  5.453630e-05  5.710878e-05
##                                                                    
## (Intercept) -2.185004e-05 -2.483305e-05 -2.820861e-05 -3.202566e-05
## ASV1236      5.382644e-04  5.617631e-04  5.861942e-04  6.115867e-04
## ASV0421     -9.610737e-04 -1.003396e-03 -1.047429e-03 -1.093228e-03
## ASV0691     -8.226594e-04 -8.575056e-04 -8.936397e-04 -9.310939e-04
## ASV0899     -2.759386e-06 -2.001907e-06 -1.140288e-06 -1.653389e-07
## ASV1004      1.092921e-03  1.141096e-03  1.191222e-03  1.243360e-03
## ASV1041     -7.402919e-04 -7.729549e-04 -8.069390e-04 -8.422867e-04
## ASV1058      1.016245e-03  1.061092e-03  1.107762e-03  1.156315e-03
## ASV12542     3.052825e-04  3.180964e-04  3.313732e-04  3.451233e-04
## ASV1294      1.188391e-03  1.241488e-03  1.296801e-03  1.354409e-03
## ASV13113     4.403561e-04  4.613650e-04  4.833773e-04  5.064410e-04
## ASV1318      1.030831e-03  1.076372e-03  1.123765e-03  1.173073e-03
## ASV2269     -3.075384e-04 -3.211588e-04 -3.353343e-04 -3.500830e-04
## ASV2542      6.815279e-04  7.134587e-04  7.468598e-04  7.817965e-04
## ASV2660     -5.897216e-04 -6.153191e-04 -6.419161e-04 -6.695420e-04
## ASV2737     -3.583714e-05 -3.787503e-05 -4.003390e-05 -4.232083e-05
## ASV2840      7.819429e-04  8.155957e-04  8.505354e-04  8.867971e-04
## ASV3053      4.092469e-05  4.255667e-05  4.424168e-05  4.598059e-05
## ASV3077      2.444476e-04  2.550791e-04  2.661305e-04  2.776148e-04
## ASV3134      8.838855e-04  9.257615e-04  9.696114e-04  1.015527e-03
## ASV3140      3.850604e-04  4.029916e-04  4.217348e-04  4.413245e-04
## ASV3579      1.647343e-04  1.733438e-04  1.824306e-04  1.920228e-04
## ASV6119     -3.074206e-04 -3.210306e-04 -3.351947e-04 -3.499312e-04
## ASV7557     -3.073589e-04 -3.209634e-04 -3.351214e-04 -3.498513e-04
## ASV8422      1.668888e-04  1.739221e-04  1.812143e-04  1.887720e-04
## ASV1086     -8.355610e-05 -8.705599e-05 -9.068343e-05 -9.444165e-05
## ASV1310      5.887453e-04  6.151118e-04  6.425821e-04  6.711957e-04
## ASV15750    -1.440261e-04 -1.502404e-04 -1.566915e-04 -1.633853e-04
## ASV16905    -3.073347e-04 -3.209369e-04 -3.350926e-04 -3.498198e-04
## ASV2033      5.975375e-04  6.257605e-04  6.553025e-04  6.862236e-04
## ASV2089      2.111079e-04  2.205083e-04  2.302956e-04  2.404826e-04
## ASV2127      8.421957e-04  8.795698e-04  9.184813e-04  9.589832e-04
## ASV2725      9.424827e-04  9.832846e-04  1.025672e-03  1.069692e-03
## ASV2804     -3.073222e-04 -3.209236e-04 -3.350783e-04 -3.498047e-04
## ASV3075      6.085436e-04  6.359548e-04  6.645378e-04  6.943381e-04
## ASV3327      5.811098e-04  6.083274e-04  6.367987e-04  6.665797e-04
## ASV3342      6.280037e-04  6.569471e-04  6.871794e-04  7.187540e-04
## ASV3532     -5.660770e-04 -5.921216e-04 -6.193236e-04 -6.477309e-04
## ASV3600      7.160403e-04  7.488344e-04  7.830742e-04  8.188189e-04
## ASV4013      5.947440e-04  6.212871e-04  6.489360e-04  6.777298e-04
## ASV4136      5.841084e-04  6.096320e-04  6.361712e-04  6.637579e-04
## ASV4195      3.072357e-04  3.208294e-04  3.349759e-04  3.496933e-04
## ASV4407     -3.071741e-04 -3.207623e-04 -3.349027e-04 -3.496135e-04
## ASV4717      1.278644e-05  1.293985e-05  1.306550e-05  1.315983e-05
## ASV6794      3.107906e-04  3.239402e-04  3.375782e-04  3.517173e-04
## ASV8324     -3.071545e-04 -3.207406e-04 -3.348787e-04 -3.495870e-04
## ASV8981     -7.581665e-05 -7.853363e-05 -8.129952e-05 -8.410979e-05
## ASV9859      2.512043e-04  2.638030e-04  2.770593e-04  2.910094e-04
## ASV0936     -4.841780e-04 -5.057718e-04 -5.282647e-04 -5.516887e-04
## ASV12683    -5.327127e-05 -5.597138e-05 -5.881012e-05 -6.179435e-05
## ASV1293      7.099592e-04  7.411669e-04  7.736303e-04  8.073900e-04
## ASV13055    -7.255100e-05 -7.552797e-05 -7.860266e-05 -8.177586e-05
## ASV17063    -3.070554e-04 -3.206333e-04 -3.347627e-04 -3.494616e-04
## ASV2228      3.069939e-04  3.205663e-04  3.346896e-04  3.493820e-04
## ASV2769     -5.057624e-05 -5.223009e-05 -5.389684e-05 -5.557181e-05
## ASV2803      1.420879e-04  1.479730e-04  1.540651e-04  1.603687e-04
## ASV2896      3.932169e-04  4.112984e-04  4.301894e-04  4.499249e-04
## ASV3062      1.293108e-04  1.360968e-04  1.432612e-04  1.508265e-04
## ASV3107      4.735347e-04  4.952689e-04  5.179664e-04  5.416669e-04
## ASV3265      9.225570e-04  9.630354e-04  1.005136e-03  1.048909e-03
## ASV3666     -2.251013e-05 -2.364689e-05 -2.484298e-05 -2.610165e-05
## ASV4497      2.190441e-04  2.287056e-04  2.387602e-04  2.492213e-04
## ASV6914     -1.100540e-04 -1.151467e-04 -1.204662e-04 -1.260217e-04
## ASV0576     -1.076459e-03 -1.122491e-03 -1.170264e-03 -1.219826e-03
## ASV0673      2.966548e-04  3.109782e-04  3.259920e-04  3.417282e-04
## ASV0772      3.343002e-04  3.493974e-04  3.651427e-04  3.815613e-04
## ASV0862     -2.574210e-04 -2.680102e-04 -2.789588e-04 -2.902719e-04
## ASV0898      2.869033e-04  3.008453e-04  3.154699e-04  3.308105e-04
## ASV0910      6.136846e-04  6.429278e-04  6.735601e-04  7.056466e-04
## ASV0964     -3.917264e-04 -4.086489e-04 -4.262251e-04 -4.444737e-04
## ASV10059     2.886259e-04  3.025406e-04  3.171332e-04  3.324372e-04
## ASV10263    -3.073357e-04 -3.209396e-04 -3.350975e-04 -3.498274e-04
## ASV1088      3.270143e-04  3.427156e-04  3.591778e-04  3.764387e-04
## ASV1101      5.382657e-04  5.624726e-04  5.876995e-04  6.139829e-04
## ASV1183      3.471072e-04  3.629933e-04  3.795753e-04  3.968808e-04
## ASV11956     1.274270e-04  1.325249e-04  1.377855e-04  1.432106e-04
## ASV12774    -4.947663e-05 -5.195775e-05 -5.456538e-05 -5.730594e-05
## ASV1321      1.501844e-04  1.581865e-04  1.666423e-04  1.755791e-04
## ASV13793    -3.072634e-04 -3.208607e-04 -3.350114e-04 -3.497335e-04
## ASV14482    -3.172600e-05 -3.345260e-05 -3.527541e-05 -3.719952e-05
## ASV15483     2.216931e-04  2.319929e-04  2.427608e-04  2.540172e-04
## ASV2062      1.370683e-03  1.432535e-03  1.497025e-03  1.564253e-03
## ASV2132      6.332470e-04  6.626922e-04  6.934750e-04  7.256532e-04
## ASV2413      8.775477e-04  9.163531e-04  9.567458e-04  9.987802e-04
## ASV2490      5.716688e-04  5.963887e-04  6.220672e-04  6.487319e-04
## ASV2594      3.211056e-04  3.357012e-04  3.509365e-04  3.668378e-04
## ASV2822     -3.073700e-04 -3.209776e-04 -3.351394e-04 -3.498737e-04
## ASV2863      5.334997e-04  5.568586e-04  5.811502e-04  6.064041e-04
## ASV2910      6.946424e-04  7.249610e-04  7.564824e-04  7.892444e-04
## ASV2980      2.520892e-04  2.631183e-04  2.745840e-04  2.864993e-04
## ASV3307      3.072674e-04  3.208657e-04  3.350175e-04  3.497409e-04
## ASV3474      5.013949e-04  5.253913e-04  5.505367e-04  5.768858e-04
## ASV3502      1.014532e-03  1.060524e-03  1.108500e-03  1.158535e-03
## ASV4236      5.031305e-04  5.248960e-04  5.475057e-04  5.709838e-04
## ASV4842     -1.692301e-04 -1.768448e-04 -1.847786e-04 -1.930426e-04
## ASV4894     -3.073433e-04 -3.209489e-04 -3.351088e-04 -3.498410e-04
## ASV5290      3.834613e-04  4.008647e-04  4.190187e-04  4.379520e-04
## ASV5501      7.148580e-05  7.471275e-05  7.808061e-05  8.159538e-05
## ASV5795      2.629973e-04  2.753645e-04  2.883056e-04  3.018466e-04
## ASV5987     -3.073712e-04 -3.209797e-04 -3.351427e-04 -3.498785e-04
## ASV6267     -3.073096e-04 -3.209125e-04 -3.350694e-04 -3.497986e-04
## ASV6862      5.832753e-04  6.081499e-04  6.339606e-04  6.607321e-04
## ASV7145      1.053885e-04  1.097366e-04  1.142389e-04  1.188991e-04
## ASV7673     -3.072912e-04 -3.208923e-04 -3.350472e-04 -3.497742e-04
## ASV7789      1.239226e-04  1.305582e-04  1.375752e-04  1.449972e-04
## ASV7809     -3.189183e-05 -3.272609e-05 -3.353972e-05 -3.432679e-05
## ASV8002     -3.072511e-04 -3.208493e-04 -3.350010e-04 -3.497247e-04
## ASV8205      1.815263e-04  1.898053e-04  1.984490e-04  2.074727e-04
## ASV9155     -2.306015e-04 -2.407279e-04 -2.512587e-04 -2.622064e-04
## ASV9221     -2.803443e-05 -2.859559e-05 -2.911403e-05 -2.958187e-05
## ASV9311     -3.071722e-04 -3.207635e-04 -3.349080e-04 -3.496239e-04
## ASV9557     -3.071106e-04 -3.206964e-04 -3.348349e-04 -3.495442e-04
## ASV9936     -3.070491e-04 -3.206293e-04 -3.347617e-04 -3.494644e-04
## ASV1445      7.257096e-04  7.592801e-04  7.943597e-04  8.310123e-04
## ASV4232      6.208260e-04  6.502762e-04  6.811209e-04  7.134261e-04
## ASV6479      9.331759e-06  1.088047e-05  1.259890e-05  1.450288e-05
## ASV0142     -1.544617e-03 -1.611899e-03 -1.681837e-03 -1.754512e-03
## ASV0378     -5.005280e-04 -5.217556e-04 -5.437629e-04 -5.665677e-04
## ASV1122      9.596044e-04  1.004027e-03  1.050446e-03  1.098947e-03
## ASV0123     -1.512325e-03 -1.578121e-03 -1.646506e-03 -1.717559e-03
## ASV2064      1.517901e-04  1.579308e-04  1.642717e-04  1.708152e-04
## ASV4459     -1.674782e-04 -1.747896e-04 -1.823895e-04 -1.902865e-04
## ASV0448      2.885613e-04  3.032670e-04  3.187525e-04  3.350607e-04
## ASV0397      7.129841e-04  7.455952e-04  7.796368e-04  8.151662e-04
## ASV0485      9.899295e-04  1.034482e-03  1.080928e-03  1.129340e-03
## ASV1566      8.343506e-04  8.724117e-04  9.121323e-04  9.535779e-04
## ASV1365      5.418474e-04  5.666836e-04  5.926142e-04  6.196835e-04
## ASV1065      1.108524e-03  1.159217e-03  1.212134e-03  1.267363e-03
## ASV0722     -2.027270e-05 -2.095124e-05 -2.164014e-05 -2.233851e-05
## ASV12660    -5.070831e-04 -5.290182e-04 -5.518070e-04 -5.754748e-04
## ASV0223     -1.923388e-05 -1.996284e-05 -2.070857e-05 -2.147014e-05
## ASV0229      5.008955e-04  5.243008e-04  5.487794e-04  5.743786e-04
## ASV0877     -1.800664e-04 -1.874294e-04 -1.950384e-04 -2.028971e-04
## ASV0983      1.006488e-03  1.051372e-03  1.098123e-03  1.146806e-03
## ASV0626     -3.135024e-04 -3.258559e-04 -3.385774e-04 -3.516673e-04
## ASV4146     -5.398999e-05 -5.627794e-05 -5.865032e-05 -6.110926e-05
## ASV4175     -6.233583e-04 -6.517493e-04 -6.813734e-04 -7.122787e-04
## ASV2082     -5.406555e-05 -5.738240e-05 -6.092635e-05 -6.471434e-05
## ASV2272      4.551394e-04  4.763543e-04  4.985392e-04  5.217369e-04
## ASV2245     -5.453059e-04 -5.703677e-04 -5.965378e-04 -6.238614e-04
## ASV0590     -3.454178e-04 -3.625720e-04 -3.806013e-04 -3.995518e-04
## ASV0217     -4.636515e-04 -4.810318e-04 -4.988362e-04 -5.170531e-04
## ASV0416      4.862089e-04  5.064680e-04  5.274421e-04  5.491452e-04
## ASV1056      6.180771e-04  6.477189e-04  6.787828e-04  7.113363e-04
## ASV7777     -5.387414e-04 -5.633501e-04 -5.890358e-04 -6.158415e-04
## ASV0455      1.134761e-04  1.190944e-04  1.249938e-04  1.311879e-04
## ASV0604      1.311256e-04  1.383472e-04  1.459931e-04  1.540894e-04
## ASV6100     -4.985861e-04 -5.214616e-04 -5.453478e-04 -5.702860e-04
## ASV11359    -5.541439e-04 -5.791873e-04 -6.053007e-04 -6.325244e-04
## ASV6604      4.008055e-04  4.196371e-04  4.393418e-04  4.599590e-04
## ASV5004     -3.247932e-04 -3.394361e-04 -3.547020e-04 -3.706142e-04
## ASV1483     -3.008604e-04 -3.145383e-04 -3.288082e-04 -3.436931e-04
## ASV9773     -6.377353e-04 -6.668975e-04 -6.973388e-04 -7.291108e-04
## ASV4059      6.892976e-05  7.284352e-05  7.699841e-05  8.141029e-05
## ASV1193      1.035815e-03  1.082951e-03  1.132133e-03  1.183440e-03
## ASV4610     -7.529454e-05 -7.730699e-05 -7.928633e-05 -8.122163e-05
## ASV0742     -3.651844e-04 -3.797095e-04 -3.946797e-04 -4.100968e-04
## ASV1502     -1.311562e-05 -1.437674e-05 -1.575160e-05 -1.724973e-05
## ASV0195     -1.233710e-04 -1.298300e-04 -1.366416e-04 -1.438255e-04
## ASV1213      3.169583e-04  3.303221e-04  3.441705e-04  3.585141e-04
## ASV1648     -4.709119e-04 -4.923468e-04 -5.147139e-04 -5.380503e-04
## ASV6984     -3.543259e-04 -3.706303e-04 -3.876601e-04 -4.054454e-04
## ASV0396     -2.350998e-04 -2.429228e-04 -2.508316e-04 -2.588079e-04
## ASV4297      5.201263e-04  5.426857e-04  5.661275e-04  5.904784e-04
## ASV2622      1.192176e-03  1.244654e-03  1.299255e-03  1.356049e-03
## ASV3512      1.994995e-04  2.098616e-04  2.207939e-04  2.323297e-04
## ASV2411      4.256714e-04  4.459625e-04  4.672178e-04  4.894824e-04
## ASV2291     -1.141285e-04 -1.201356e-04 -1.264793e-04 -1.331797e-04
## ASV0807      5.094341e-04  5.346343e-04  5.611082e-04  5.889214e-04
## ASV1292      2.689911e-04  2.808389e-04  2.931685e-04  3.059963e-04
## ASV1035      1.216686e-04  1.266395e-04  1.317807e-04  1.370957e-04
## ASV0070     -2.684595e-04 -2.788930e-04 -2.896153e-04 -3.006229e-04
## ASV0255      1.170258e-04  1.223218e-04  1.278419e-04  1.335939e-04
## ASV0057     -1.214994e-03 -1.266988e-03 -1.320945e-03 -1.376914e-03
## ASV0077     -1.657506e-04 -1.717063e-04 -1.777763e-04 -1.839524e-04
## ASV0625      1.219710e-03  1.272915e-03  1.328225e-03  1.385704e-03
## ASV2464      5.850399e-04  6.100622e-04  6.360352e-04  6.629855e-04
## ASV1315      1.103421e-03  1.155534e-03  1.210083e-03  1.267180e-03
## ASV2673      8.069961e-04  8.454859e-04  8.858113e-04  9.280596e-04
## ASV2161      3.336179e-04  3.496418e-04  3.664401e-04  3.840505e-04
## ASV0337     -5.169324e-04 -5.401183e-04 -5.642793e-04 -5.894508e-04
## ASV7680     -6.143483e-04 -6.425653e-04 -6.720310e-04 -7.027965e-04
## ASV0611      1.347588e-03  1.410544e-03  1.476388e-03  1.545248e-03
## ASV3118     -4.568056e-04 -4.780354e-04 -5.002261e-04 -5.234191e-04
## ASV1284      4.817567e-04  5.041080e-04  5.274693e-04  5.518839e-04
## ASV0889      3.603718e-04  3.764850e-04  3.932756e-04  4.107689e-04
## ASV4649     -3.797970e-04 -3.970916e-04 -4.151375e-04 -4.339641e-04
## ASV1108     -4.986811e-04 -5.226158e-04 -5.477034e-04 -5.739995e-04
## ASV0738     -4.335205e-05 -4.243762e-05 -4.122334e-05 -3.967458e-05
## ASV0473      7.556387e-05  7.908834e-05  8.277605e-05  8.663460e-05
## ASV0598     -5.329481e-04 -5.555150e-04 -5.789124e-04 -6.031601e-04
## ASV0429      8.729417e-04  9.120352e-04  9.527666e-04  9.951945e-04
## ASV1549      9.011006e-04  9.442744e-04  9.895225e-04  1.036945e-03
## ASV1203      6.622282e-04  6.921335e-04  7.233160e-04  7.558237e-04
## ASV4532      2.509760e-05  2.586500e-05  2.663697e-05  2.741183e-05
## ASV0274     -6.472818e-04 -6.748549e-04 -7.034592e-04 -7.331212e-04
## ASV0163     -9.218209e-04 -9.608440e-04 -1.001303e-03 -1.043231e-03
## ASV1298      3.744959e-04  3.903607e-04  4.068133e-04  4.238687e-04
## ASV9424     -8.180972e-04 -8.560005e-04 -8.956122e-04 -9.370051e-04
## ASV0412      1.242190e-03  1.297994e-03  1.356161e-03  1.416779e-03
## ASV0284      5.444662e-04  5.678681e-04  5.921663e-04  6.173859e-04
## ASV0620     -4.295522e-04 -4.502326e-04 -4.719114e-04 -4.946364e-04
## ASV0153     -8.836553e-04 -9.252595e-04 -9.687966e-04 -1.014354e-03
## ASV0498      1.178311e-04  1.253601e-04  1.334055e-04  1.420034e-04
## ASV0097      6.360131e-04  6.662698e-04  6.979640e-04  7.311636e-04
## ASV0104     -2.869033e-03 -2.998985e-03 -3.134527e-03 -3.275872e-03
## ASV1282      5.044534e-04  5.277874e-04  5.521673e-04  5.776368e-04
## ASV3883     -2.974361e-04 -3.116312e-04 -3.265002e-04 -3.420746e-04
## ASV0801      3.007943e-04  3.155839e-04  3.311108e-04  3.474118e-04
## ASV1611     -1.116606e-03 -1.168333e-03 -1.222391e-03 -1.278879e-03
## ASV0227     -4.186747e-04 -4.393298e-04 -4.610240e-04 -4.838101e-04
## ASV0833      4.491944e-04  4.712900e-04  4.944896e-04  5.188485e-04
## ASV0718      1.033755e-03  1.081082e-03  1.130492e-03  1.182069e-03
## ASV1139      3.596280e-04  3.742502e-04  3.893474e-04  4.049239e-04
## ASV0766     -2.763649e-04 -2.884521e-04 -3.010189e-04 -3.140801e-04
## ASV2091      1.354528e-03  1.413407e-03  1.474598e-03  1.538171e-03
## ASV1238     -7.185323e-05 -7.361920e-05 -7.532680e-05 -7.696195e-05
## ASV9193     -1.377372e-04 -1.452832e-04 -1.532699e-04 -1.617244e-04
## ASV0290     -1.247055e-04 -1.312445e-04 -1.381406e-04 -1.454135e-04
## ASV0231      1.089586e-03  1.138793e-03  1.190106e-03  1.243605e-03
## ASV0185      2.416862e-04  2.572030e-04  2.738064e-04  2.915762e-04
## ASV2330      3.103441e-04  3.239367e-04  3.380725e-04  3.527691e-04
## ASV3119     -3.784325e-04 -3.975483e-04 -4.176663e-04 -4.388409e-04
## ASV2368     -5.086193e-04 -5.327787e-04 -5.580823e-04 -5.845840e-04
## ASV0122     -3.827260e-04 -3.991417e-04 -4.161830e-04 -4.338673e-04
## ASV1044      7.063253e-04  7.406237e-04  7.766068e-04  8.143582e-04
## ASV0160     -9.378905e-04 -9.774744e-04 -1.018500e-03 -1.061001e-03
## ASV0326      6.298987e-04  6.587517e-04  6.888738e-04  7.203160e-04
## ASV1388      1.098258e-03  1.148063e-03  1.200016e-03  1.254199e-03
## ASV0792      1.233865e-03  1.288742e-03  1.345887e-03  1.405378e-03
## ASV0036     -7.969214e-04 -8.341516e-04 -8.730846e-04 -9.137943e-04
## ASV2125      1.283552e-03  1.341708e-03  1.402368e-03  1.465626e-03
## ASV1075      2.516572e-04  2.637065e-04  2.763345e-04  2.895690e-04
## ASV0390      2.562615e-04  2.694572e-04  2.833685e-04  2.980366e-04
## ASV3790     -1.040321e-03 -1.088365e-03 -1.138558e-03 -1.190991e-03
## ASV1535     -9.072752e-05 -9.549523e-05 -1.005301e-04 -1.058484e-04
## ASV0263      2.142921e-04  2.241322e-04  2.344071e-04  2.451345e-04
## ASV0675      1.727329e-03  1.808932e-03  1.894353e-03  1.983767e-03
## ASV3348      1.703270e-04  1.788273e-04  1.877665e-04  1.971681e-04
## ASV0058     -1.614207e-03 -1.686883e-03 -1.762642e-03 -1.841598e-03
## ASV4142      4.035284e-04  4.215475e-04  4.403134e-04  4.598516e-04
## ASV0059     -1.389871e-03 -1.452228e-03 -1.517209e-03 -1.584910e-03
## ASV0013     -2.911899e-03 -3.043767e-03 -3.181306e-03 -3.324734e-03
## ASV0033     -8.689535e-04 -9.096831e-04 -9.522884e-04 -9.968524e-04
## ASV4354     -3.671876e-04 -3.832805e-04 -4.000223e-04 -4.174348e-04
## ASV0022     -9.155426e-04 -9.583239e-04 -1.003063e-03 -1.049845e-03
## ASV0134     -2.339239e-04 -2.454972e-04 -2.576547e-04 -2.704261e-04
## ASV0415     -1.710785e-04 -1.771110e-04 -1.832532e-04 -1.894968e-04
## ASV10103    -6.373140e-04 -6.667613e-04 -6.975271e-04 -7.296665e-04
## ASV1613      1.012699e-03  1.057664e-03  1.104479e-03  1.153209e-03
## ASV0135     -3.185541e-05 -3.103198e-05 -2.996434e-05 -2.862406e-05
## ASV0469     -1.260922e-03 -1.316684e-03 -1.374726e-03 -1.435126e-03
## ASV0471      8.140488e-04  8.513563e-04  8.903060e-04  9.309641e-04
## ASV0451     -2.324804e-04 -2.441261e-04 -2.563743e-04 -2.692573e-04
## ASV0747      3.277840e-04  3.439196e-04  3.608641e-04  3.786582e-04
## ASV1314     -4.987791e-04 -5.230692e-04 -5.485629e-04 -5.753213e-04
## ASV0425     -1.418954e-03 -1.480412e-03 -1.544261e-03 -1.610569e-03
## ASV0559     -8.069204e-04 -8.418804e-04 -8.782107e-04 -9.159535e-04
## ASV0148     -8.721587e-04 -9.095862e-04 -9.484341e-04 -9.887401e-04
## ASV0129     -4.196087e-04 -4.362253e-04 -4.533380e-04 -4.709462e-04
## ASV1072      4.211738e-04  4.390152e-04  4.575106e-04  4.766751e-04
## ASV2390      3.003941e-04  3.131155e-04  3.263015e-04  3.399624e-04
## ASV0548      9.404241e-04  9.837804e-04  1.029071e-03  1.076377e-03
## ASV0168     -1.394753e-03 -1.456874e-03 -1.521574e-03 -1.588946e-03
## ASV0066     -1.038337e-03 -1.084990e-03 -1.133613e-03 -1.184279e-03
## ASV0468     -3.859509e-04 -4.035457e-04 -4.219084e-04 -4.410697e-04
## ASV0172     -1.952505e-04 -2.017819e-04 -2.083847e-04 -2.150432e-04
## ASV0236     -5.099327e-04 -5.298783e-04 -5.503972e-04 -5.714860e-04
## ASV0250      6.465422e-05  7.127709e-05  7.852293e-05  8.644622e-05
## ASV0338     -5.685566e-05 -5.750966e-05 -5.802563e-05 -5.838458e-05
## ASV0450     -4.526724e-06 -4.692115e-06 -4.860895e-06 -5.032880e-06
## ASV0377      1.146186e-03  1.198268e-03  1.252606e-03  1.309288e-03
## ASV1022      3.209750e-04  3.357640e-04  3.512142e-04  3.673536e-04
## ASV6174     -7.696489e-05 -8.029475e-05 -8.375701e-05 -8.735624e-05
## ASV0786      1.227526e-04  1.277905e-04  1.330002e-04  1.383846e-04
## ASV0053     -1.381783e-03 -1.444843e-03 -1.510659e-03 -1.579339e-03
## ASV0697     -3.864847e-04 -4.027728e-04 -4.196538e-04 -4.371414e-04
## ASV0785      1.027581e-03  1.074364e-03  1.123181e-03  1.174112e-03
## ASV1967     -6.633493e-04 -6.920472e-04 -7.218658e-04 -7.528393e-04
## ASV0385     -3.048475e-04 -3.175160e-04 -3.306287e-04 -3.441943e-04
## ASV0295      2.241814e-05  2.540555e-05  2.870345e-05  3.234041e-05
## ASV0072     -1.079856e-03 -1.126819e-03 -1.175624e-03 -1.226323e-03
## ASV0157     -4.388382e-04 -4.569347e-04 -4.756428e-04 -4.949703e-04
## ASV0501      5.163692e-04  5.412959e-04  5.674359e-04  5.948485e-04
## ASV10729    -8.461279e-04 -8.851691e-04 -9.259530e-04 -9.685523e-04
## ASV1470      3.936070e-04  4.108991e-04  4.288857e-04  4.475889e-04
## ASV0050     -2.738486e-03 -2.861391e-03 -2.989478e-03 -3.122938e-03
## ASV0411     -6.214638e-05 -6.405437e-05 -6.596116e-05 -6.785916e-05
## ASV0549      5.355406e-04  5.611886e-04  5.880688e-04  6.162405e-04
## ASV0184      3.214804e-04  3.361169e-04  3.513939e-04  3.673377e-04
## ASV0705      3.935462e-04  4.120365e-04  4.313786e-04  4.516095e-04
## ASV1715      9.814014e-04  1.026411e-03  1.073410e-03  1.122477e-03
## ASV0603      1.195488e-04  1.253338e-04  1.314039e-04  1.377739e-04
## ASV0826      3.199027e-04  3.336866e-04  3.479998e-04  3.628570e-04
## ASV0034     -1.229661e-03 -1.284028e-03 -1.340610e-03 -1.399478e-03
## ASV0838      2.601501e-04  2.717143e-04  2.837517e-04  2.962778e-04
## ASV0614     -7.010797e-04 -7.323203e-04 -7.648591e-04 -7.987421e-04
## ASV0014     -2.656680e-03 -2.776132e-03 -2.900644e-03 -3.030401e-03
## ASV0585     -1.698580e-04 -1.777752e-04 -1.860524e-04 -1.947051e-04
## ASV0016     -2.716948e-03 -2.839214e-03 -2.966669e-03 -3.099504e-03
## ASV5394     -6.959591e-04 -7.279676e-04 -7.613951e-04 -7.962996e-04
## ASV0666      5.852536e-04  6.115315e-04  6.389181e-04  6.674538e-04
## ASV2085      2.092533e-04  2.165624e-04  2.239942e-04  2.315368e-04
## ASV0003     -2.480574e-03 -2.591759e-03 -2.707622e-03 -2.828332e-03
## ASV0346     -2.426393e-05 -2.311182e-05 -2.171010e-05 -2.003196e-05
## ASV0267     -3.808394e-04 -3.967068e-04 -4.131281e-04 -4.301127e-04
## ASV0353      5.560568e-04  5.836721e-04  6.126965e-04  6.432039e-04
## ASV2419      6.978306e-04  7.288572e-04  7.611680e-04  7.948082e-04
## ASV0447      3.601177e-04  3.789820e-04  3.988843e-04  4.198840e-04
## ASV0654      1.102378e-03  1.153540e-03  1.207009e-03  1.262884e-03
## ASV0151      1.864743e-04  1.966161e-04  2.073536e-04  2.187246e-04
## ASV0065     -1.003679e-03 -1.048887e-03 -1.096014e-03 -1.145131e-03
## ASV0527      7.273897e-04  7.602640e-04  7.945458e-04  8.302887e-04
## ASV4055     -2.806921e-04 -2.942389e-04 -3.084468e-04 -3.233487e-04
## ASV0166     -8.237607e-04 -8.596572e-04 -8.969720e-04 -9.357488e-04
## ASV0417     -7.024017e-04 -7.336634e-04 -7.662221e-04 -8.001238e-04
## ASV0078     -5.571983e-04 -5.813512e-04 -6.064402e-04 -6.324915e-04
## ASV0322     -6.779871e-04 -7.073866e-04 -7.379293e-04 -7.696478e-04
## ASV0156     -8.879706e-04 -9.272865e-04 -9.682158e-04 -1.010814e-03
## ASV0648     -8.209613e-04 -8.591859e-04 -8.991485e-04 -9.409244e-04
## ASV0407      6.930343e-05  7.311614e-05  7.715522e-05  8.143507e-05
## ASV2030     -1.645457e-04 -1.712190e-04 -1.781182e-04 -1.852477e-04
## ASV0300      4.946513e-04  5.189828e-04  5.445342e-04  5.713678e-04
## ASV1150     -5.455569e-05 -5.635458e-05 -5.816820e-05 -5.999132e-05
## ASV0958      5.162758e-04  5.416917e-04  5.683909e-04  5.964405e-04
## ASV0216     -8.363024e-04 -8.725512e-04 -9.102193e-04 -9.493499e-04
## ASV0446      1.216245e-03  1.274157e-03  1.334810e-03  1.398331e-03
## ASV0367     -4.057406e-04 -4.240074e-04 -4.430510e-04 -4.629009e-04
## ASV0200     -7.606341e-04 -7.953307e-04 -8.315452e-04 -8.693386e-04
## ASV0334     -3.636539e-04 -3.774158e-04 -3.915299e-04 -4.059893e-04
## ASV1311      5.308790e-04  5.545225e-04  5.791459e-04  6.047833e-04
## ASV0458      5.760236e-04  6.019523e-04  6.289867e-04  6.571691e-04
## ASV1371      1.869162e-05  1.965005e-05  2.066005e-05  2.172453e-05
## ASV0418      7.077346e-04  7.400021e-04  7.736798e-04  8.088243e-04
## ASV0004      8.378578e-04  8.758046e-04  9.153834e-04  9.566570e-04
## ASV1943      6.050844e-04  6.318454e-04  6.597072e-04  6.887088e-04
## ASV1495     -1.665894e-04 -1.756957e-04 -1.853369e-04 -1.955465e-04
## ASV0901     -9.705608e-04 -1.016101e-03 -1.063747e-03 -1.113594e-03
## ASV0628      5.500695e-04  5.742121e-04  5.993205e-04  6.254250e-04
## ASV0400      2.206510e-04  2.303582e-04  2.404548e-04  2.509533e-04
## ASV0116     -7.546595e-04 -7.907344e-04 -8.285344e-04 -8.681415e-04
## ASV0788      6.088773e-04  6.367471e-04  6.658426e-04  6.962133e-04
## ASV0117      4.049642e-04  4.247547e-04  4.455303e-04  4.673409e-04
## ASV3137      1.052278e-04  1.098574e-04  1.146744e-04  1.196848e-04
## ASV0001      9.858627e-04  1.028645e-03  1.073099e-03  1.119274e-03
## ASV1651      6.576011e-04  6.861668e-04  7.158556e-04  7.467019e-04
## ASV1692      7.343379e-04  7.693595e-04  8.060479e-04  8.444816e-04
## ASV0660      3.954905e-04  4.119059e-04  4.288870e-04  4.464426e-04
## ASV0508      4.441048e-05  4.586269e-05  4.733125e-05  4.881328e-05
## ASV1660     -3.054728e-04 -3.203801e-04 -3.360220e-04 -3.524347e-04
## ASV0233      1.705695e-04  1.789769e-04  1.878110e-04  1.970942e-04
## ASV1343     -7.278797e-04 -7.615390e-04 -7.967104e-04 -8.334580e-04
## ASV0209      6.514168e-04  6.794241e-04  7.085046e-04  7.386883e-04
## ASV0193     -8.559645e-04 -8.935694e-04 -9.326898e-04 -9.733753e-04
## ASV0357     -3.553434e-05 -3.567846e-05 -3.569136e-05 -3.555511e-05
## ASV0198      1.881575e-04  1.969170e-04  2.060755e-04  2.156504e-04
## ASV0007      9.345440e-04  9.750974e-04  1.017236e-03  1.061006e-03
## ASV1772     -9.615514e-05 -1.003618e-04 -1.047328e-04 -1.092728e-04
## ASV0009      8.802259e-04  9.182931e-04  9.578361e-04  9.988977e-04
## ASV0006      3.401808e-04  3.535685e-04  3.673504e-04  3.815257e-04
## ASV0011     -1.020896e-03 -1.068450e-03 -1.118169e-03 -1.170147e-03
## ASV0015      7.050762e-04  7.370759e-04  7.704563e-04  8.052706e-04
## ASV0017      7.454365e-04  7.791677e-04  8.143463e-04  8.510277e-04
## ASV0235     -5.953357e-04 -6.229721e-04 -6.518555e-04 -6.820387e-04
## ASV0382      1.270572e-04  1.348331e-04  1.431197e-04  1.519512e-04
## ASV2357      9.014705e-04  9.429974e-04  9.863766e-04  1.031686e-03
## ASV0567     -6.438955e-04 -6.726008e-04 -7.025059e-04 -7.336548e-04
## ASV0165      7.116692e-04  7.440127e-04  7.777581e-04  8.129604e-04
## ASV0005      1.420518e-03  1.483812e-03  1.549730e-03  1.618364e-03
## ASV0384     -5.415940e-05 -5.532752e-05 -5.642445e-05 -5.743594e-05
## ASV0002      3.178926e-04  3.333703e-04  3.496138e-04  3.666619e-04
## ASV3017      8.232593e-04  8.594729e-04  8.971471e-04  9.363298e-04
## ASV0091      3.277061e-04  3.431860e-04  3.593889e-04  3.763479e-04
## ASV0186     -8.687743e-04 -9.088200e-04 -9.506489e-04 -9.943346e-04
## ASV0370      9.139475e-05  9.588614e-05  1.006028e-04  1.055563e-04
## ASV0018      1.482291e-03  1.548592e-03  1.617666e-03  1.689613e-03
## ASV1377      1.291553e-03  1.349095e-03  1.409028e-03  1.471437e-03
## ASV0019      1.484503e-03  1.550932e-03  1.620142e-03  1.692233e-03
## ASV0023      8.163238e-05  8.329600e-05  8.484894e-05  8.627101e-05
## ASV2194      4.962799e-04  5.196801e-04  5.441735e-04  5.698103e-04
## ASV1155     -4.461100e-05 -4.564013e-05 -4.661935e-05 -4.753795e-05
## ASV0510     -5.236508e-04 -5.450731e-04 -5.672113e-04 -5.900751e-04
## ASV2371     -5.221955e-04 -5.444259e-04 -5.674935e-04 -5.914211e-04
## ASV0024      9.662447e-06  8.037140e-06  6.157050e-06  3.996225e-06
## ASV2452      6.869615e-04  7.166885e-04  7.475644e-04  7.796215e-04
## ASV2332      5.746879e-05  6.198277e-05  6.685424e-05  7.211025e-05
## ASV2591      5.417456e-05  5.852734e-05  6.322750e-05  6.830112e-05
## ASV0521      9.780724e-04  1.024273e-03  1.072636e-03  1.123260e-03
## ASV5542      3.081488e-04  3.231068e-04  3.387913e-04  3.552368e-04
## ASV0336     -4.484240e-04 -4.686530e-04 -4.897455e-04 -5.117343e-04
## ASV10102     6.741963e-04  7.055905e-04  7.384094e-04  7.727142e-04
## ASV16823    -5.028577e-04 -5.240091e-04 -5.459358e-04 -5.686570e-04
## ASV3104      5.027627e-04  5.239061e-04  5.458240e-04  5.685357e-04
## ASV0781      2.498225e-04  2.609139e-04  2.724605e-04  2.844777e-04
## ASV10899     2.644760e-04  2.783362e-04  2.929582e-04  3.083857e-04
## ASV11222    -5.027056e-04 -5.238446e-04 -5.457580e-04 -5.684650e-04
## ASV11327    -5.026107e-04 -5.237416e-04 -5.456463e-04 -5.683438e-04
## ASV12458    -5.025158e-04 -5.236387e-04 -5.455346e-04 -5.682227e-04
## ASV1636     -4.095727e-04 -4.266456e-04 -4.443266e-04 -4.626291e-04
## ASV1890     -5.050713e-04 -5.267074e-04 -5.491754e-04 -5.725003e-04
## ASV2898      1.113740e-03  1.163204e-03  1.214707e-03  1.268319e-03
## ASV8328     -6.190929e-05 -6.253616e-05 -6.300117e-05 -6.328231e-05
## ASV0709     -9.132631e-04 -9.540384e-04 -9.965102e-04 -1.040738e-03
## ASV0856      1.563659e-04  1.642672e-04  1.725804e-04  1.813275e-04
## ASV0909     -3.589918e-04 -3.726505e-04 -3.866647e-04 -4.010281e-04
## ASV0937     -7.234997e-04 -7.568590e-04 -7.917159e-04 -8.281349e-04
## ASV11390    -5.023175e-04 -5.234239e-04 -5.453021e-04 -5.679712e-04
## ASV11966     2.822323e-04  2.963305e-04  3.111488e-04  3.267242e-04
## ASV12990     1.446973e-04  1.514379e-04  1.584793e-04  1.658333e-04
## ASV14797     5.293963e-04  5.524125e-04  5.763306e-04  6.011775e-04
## ASV14904    -5.022983e-04 -5.234037e-04 -5.452808e-04 -5.679489e-04
## ASV15304     1.590848e-04  1.677893e-04  1.769965e-04  1.867362e-04
## ASV16696    -5.022257e-04 -5.233254e-04 -5.451965e-04 -5.678581e-04
## ASV1690      2.915927e-04  3.064945e-04  3.221796e-04  3.386893e-04
## ASV2029      1.437271e-03  1.501786e-03  1.569025e-03  1.639089e-03
## ASV2834      7.783851e-04  8.140640e-04  8.513193e-04  8.902159e-04
## ASV4003      2.476197e-04  2.610109e-04  2.751698e-04  2.901424e-04
## ASV4064      5.518891e-04  5.777650e-04  6.048282e-04  6.331305e-04
## ASV4294      2.068110e-04  2.178262e-04  2.294614e-04  2.417530e-04
## ASV4609     -1.552754e-05 -1.575105e-05 -1.594587e-05 -1.610804e-05
## ASV6283     -5.022369e-04 -5.233397e-04 -5.452145e-04 -5.678804e-04
## ASV6491     -5.021421e-04 -5.232369e-04 -5.451030e-04 -5.677595e-04
## ASV7453      2.273470e-04  2.393774e-04  2.520757e-04  2.654801e-04
## ASV7959      6.111640e-05  6.554437e-05  7.030503e-05  7.542281e-05
## ASV8219      5.020875e-04  5.231787e-04  5.450410e-04  5.676937e-04
## ASV8547     -5.019928e-04 -5.230759e-04 -5.449296e-04 -5.675729e-04
## ASV9319      3.628139e-04  3.800383e-04  3.980717e-04  4.169509e-04
## ASV9382     -5.019399e-04 -5.230189e-04 -5.448682e-04 -5.675069e-04
## ASV11516    -5.018452e-04 -5.229162e-04 -5.447568e-04 -5.673861e-04
## ASV14377    -5.017506e-04 -5.228135e-04 -5.446454e-04 -5.672654e-04
## ASV1867      7.768765e-04  8.130596e-04  8.508863e-04  8.904274e-04
## ASV1895     -1.692470e-04 -1.761973e-04 -1.833885e-04 -1.908254e-04
## ASV3168      3.208504e-04  3.348879e-04  3.494758e-04  3.646296e-04
## ASV4449      6.343308e-04  6.617806e-04  6.903090e-04  7.199502e-04
## ASV6596      3.961483e-04  4.160058e-04  4.368900e-04  4.588555e-04
## ASV7492     -1.703349e-04 -1.760554e-04 -1.818527e-04 -1.877164e-04
## ASV9854     -2.541686e-04 -2.645112e-04 -2.752048e-04 -2.862560e-04
## ASV6296      5.015634e-04  5.226115e-04  5.444276e-04  5.670306e-04
## ASV4201      2.013149e-04  2.129115e-04  2.252235e-04  2.382968e-04
## ASV0552      1.302105e-03  1.362958e-03  1.426597e-03  1.493143e-03
## ASV3671     -8.941636e-05 -9.202607e-05 -9.463003e-05 -9.721913e-05
## ASV3529     -9.091069e-05 -9.311378e-05 -9.525269e-05 -9.731267e-05
## ASV1060      3.295598e-04  3.451248e-04  3.614214e-04  3.784837e-04
## ASV0239     -7.045142e-04 -7.343548e-04 -7.652946e-04 -7.973598e-04
## ASV5711     -6.534875e-04 -6.817074e-04 -7.110298e-04 -7.414888e-04
## ASV4152     -8.775261e-04 -9.165896e-04 -9.572811e-04 -9.996596e-04
## ASV1461      7.675011e-04  8.003432e-04  8.344248e-04  8.697786e-04
## ASV2877      6.395455e-04  6.680801e-04  6.977983e-04  7.287411e-04
## ASV0012      4.991362e-04  5.231044e-04  5.482275e-04  5.745612e-04
## ASV9823      1.663836e-04  1.731777e-04  1.801952e-04  1.874384e-04
## ASV0008      5.420467e-04  5.678045e-04  5.947814e-04  6.230344e-04
## ASV7832     -5.359964e-04 -5.595385e-04 -5.840379e-04 -6.095281e-04
## ASV1915      5.332476e-05  5.656928e-05  6.002008e-05  6.368991e-05
## ASV0055      3.748909e-04  3.918248e-04  4.094810e-04  4.278866e-04
## ASV0032      8.936669e-04  9.329279e-04  9.737706e-04  1.016247e-03
## ASV2977     -7.385928e-04 -7.714349e-04 -8.056419e-04 -8.412629e-04
## ASV0466      7.378131e-04  7.696820e-04  8.027869e-04  8.371639e-04
## ASV3866      8.064771e-04  8.438623e-04  8.829330e-04  9.237607e-04
## ASV0040      1.080077e-03  1.130822e-03  1.183915e-03  1.239463e-03
## ASV0496     -7.732428e-05 -8.258868e-05 -8.823790e-05 -9.430064e-05
## ASV0052      1.282790e-03  1.340282e-03  1.400190e-03  1.462601e-03
## ASV3828     -7.840508e-04 -8.187654e-04 -8.549151e-04 -8.925517e-04
## ASV1930      4.976601e-04  5.203537e-04  5.440294e-04  5.687245e-04
## ASV2126      8.038194e-04  8.400649e-04  8.778518e-04  9.172376e-04
## ASV0793      5.073544e-04  5.323387e-04  5.585768e-04  5.861325e-04
## ASV0299     -3.171843e-04 -3.298222e-04 -3.428566e-04 -3.562909e-04
## ASV0208      7.713927e-04  8.081244e-04  8.466013e-04  8.869057e-04
## ASV0511     -3.833184e-04 -3.984185e-04 -4.139635e-04 -4.299525e-04
## ASV1123     -5.191786e-04 -5.409737e-04 -5.635553e-04 -5.869409e-04
## ASV0099     -2.913297e-04 -3.040438e-04 -3.172529e-04 -3.309703e-04
## ASV0752     -7.120068e-05 -7.527169e-05 -7.958743e-05 -8.416261e-05
## ASV0883      1.417839e-05  1.534597e-05  1.660835e-05  1.797277e-05
## ASV0683      6.877364e-04  7.203454e-04  7.544875e-04  7.902329e-04
## ASV4117     -7.905404e-04 -8.256527e-04 -8.622253e-04 -9.003113e-04
## ASV2172      3.006945e-04  3.144937e-04  3.289011e-04  3.439410e-04
## ASV0330     -5.467848e-04 -5.719446e-04 -5.982199e-04 -6.256566e-04
## ASV0728      5.296538e-04  5.549052e-04  5.813490e-04  6.090398e-04
## ASV0499      1.037833e-03  1.087088e-03  1.138670e-03  1.192688e-03
## ASV0120     -1.126319e-03 -1.177411e-03 -1.230702e-03 -1.286275e-03
## ASV1446      7.783151e-05  8.002077e-05  8.218687e-05  8.431887e-05
## ASV17171    -7.531093e-04 -7.867574e-04 -8.218229e-04 -8.583593e-04
## ASV0533      2.230310e-04  2.338450e-04  2.451902e-04  2.570929e-04
## ASV2495     -3.136733e-04 -3.284919e-04 -3.440135e-04 -3.602722e-04
## ASV5582      2.552866e-04  2.657007e-04  2.764594e-04  2.875671e-04
## ASV1488      2.517165e-04  2.637686e-04  2.763959e-04  2.896252e-04
## ASV0682      7.221983e-04  7.564330e-04  7.922804e-04  8.298150e-04
## ASV0068     -5.792907e-05 -6.191396e-05 -6.618982e-05 -7.077796e-05
## ASV1987     -4.025342e-04 -4.225639e-04 -4.436144e-04 -4.657385e-04
## ASV0035      1.079807e-04  1.105778e-04  1.130709e-04  1.154358e-04
## ASV7192     -4.967190e-04 -5.179512e-04 -5.399888e-04 -5.628540e-04
## ASV0873      6.181761e-05  6.347029e-05  6.509924e-05  6.669628e-05
## ASV4749      1.889629e-05  1.759463e-05  1.604062e-05  1.420697e-05
## ASV2174      4.683025e-04  4.879577e-04  5.083239e-04  5.294172e-04
## ASV1476     -4.247277e-04 -4.442597e-04 -4.646678e-04 -4.859901e-04
## ASV0740     -1.048582e-03 -1.098066e-03 -1.149859e-03 -1.204067e-03
## ASV0170      2.191232e-04  2.291257e-04  2.395678e-04  2.504677e-04
## ASV2466     -9.327242e-04 -9.750263e-04 -1.019165e-03 -1.065214e-03
## ASV1709      7.187804e-04  7.508884e-04  7.843435e-04  8.191953e-04
## ASV6170     -6.736187e-04 -7.048368e-04 -7.374622e-04 -7.715547e-04
## ASV3673      7.718081e-04  8.076448e-04  8.451033e-04  8.842530e-04
## ASV1745      5.980022e-05  6.261579e-05  6.556087e-05  6.864101e-05
##                                                                    
## (Intercept) -3.633874e-05 -4.120855e-05 -4.670257e-05 -5.289567e-05
## ASV1236      6.379701e-04  6.653740e-04  6.938282e-04  7.233626e-04
## ASV0421     -1.140850e-03 -1.190353e-03 -1.241795e-03 -1.295233e-03
## ASV0691     -9.698996e-04 -1.010088e-03 -1.051688e-03 -1.094731e-03
## ASV0899      9.326934e-07  2.164131e-06  3.539870e-06  5.071382e-06
## ASV1004      1.297576e-03  1.353934e-03  1.412501e-03  1.473342e-03
## ASV1041     -8.790413e-04 -9.172460e-04 -9.569443e-04 -9.981801e-04
## ASV1058      1.206814e-03  1.259321e-03  1.313899e-03  1.370613e-03
## ASV12542     3.593570e-04  3.740840e-04  3.893140e-04  4.050558e-04
## ASV1294      1.414392e-03  1.476833e-03  1.541815e-03  1.609424e-03
## ASV13113     5.306064e-04  5.559259e-04  5.824548e-04  6.102505e-04
## ASV1318      1.224358e-03  1.277684e-03  1.333113e-03  1.390712e-03
## ASV2269     -3.654234e-04 -3.813742e-04 -3.979543e-04 -4.151825e-04
## ASV2542      8.183367e-04  8.565510e-04  8.965131e-04  9.382995e-04
## ASV2660     -6.982263e-04 -7.279984e-04 -7.588877e-04 -7.909232e-04
## ASV2737     -4.474324e-05 -4.730888e-05 -5.002587e-05 -5.290270e-05
## ASV2840      9.244158e-04  9.634258e-04  1.003861e-03  1.045755e-03
## ASV3053      4.777425e-05  4.962347e-05  5.152902e-05  5.349165e-05
## ASV3077      2.895455e-04  3.019360e-04  3.147997e-04  3.281504e-04
## ASV3134      1.063605e-03  1.113946e-03  1.166656e-03  1.221843e-03
## ASV3140      4.617963e-04  4.831870e-04  5.055347e-04  5.288789e-04
## ASV3579      2.021504e-04  2.128451e-04  2.241406e-04  2.360726e-04
## ASV6119     -3.652584e-04 -3.811950e-04 -3.977597e-04 -4.149713e-04
## ASV7557     -3.651714e-04 -3.811002e-04 -3.976565e-04 -4.148590e-04
## ASV8422      1.966018e-04  2.047101e-04  2.131034e-04  2.217881e-04
## ASV1086     -9.833384e-05 -1.023632e-04 -1.065329e-04 -1.108460e-04
## ASV1310      7.009926e-04  7.320138e-04  7.643008e-04  7.978958e-04
## ASV15750    -1.703279e-04 -1.775250e-04 -1.849823e-04 -1.927051e-04
## ASV16905    -3.651370e-04 -3.810627e-04 -3.976156e-04 -4.148144e-04
## ASV2033      7.185862e-04  7.524556e-04  7.878995e-04  8.249887e-04
## ASV2089      2.510826e-04  2.621088e-04  2.735747e-04  2.854938e-04
## ASV2127      1.001129e-03  1.044975e-03  1.090574e-03  1.137986e-03
## ASV2725      1.115391e-03  1.162814e-03  1.212007e-03  1.263017e-03
## ASV2804     -3.651210e-04 -3.810457e-04 -3.975977e-04 -4.147956e-04
## ASV3075      7.254025e-04  7.577792e-04  7.915182e-04  8.266709e-04
## ASV3327      6.977283e-04  7.303052e-04  7.643731e-04  7.999976e-04
## ASV3342      7.517261e-04  7.861527e-04  8.220929e-04  8.596076e-04
## ASV3532     -6.773930e-04 -7.083615e-04 -7.406894e-04 -7.744319e-04
## ASV3600      8.561295e-04  8.950691e-04  9.357031e-04  9.780987e-04
## ASV4013      7.077087e-04  7.389136e-04  7.713862e-04  8.051689e-04
## ASV4136      6.924246e-04  7.222041e-04  7.531295e-04  7.852338e-04
## ASV4195      3.649999e-04  3.809142e-04  3.974548e-04  4.146405e-04
## ASV4407     -3.649130e-04 -3.808195e-04 -3.973517e-04 -4.145283e-04
## ASV4717      1.321900e-05  1.323892e-05  1.321523e-05  1.314330e-05
## ASV6794      3.663704e-04  3.815502e-04  3.972694e-04  4.135405e-04
## ASV8324     -3.648837e-04 -3.807872e-04 -3.973161e-04 -4.144890e-04
## ASV8981     -8.695921e-05 -8.984173e-05 -9.275042e-05 -9.567742e-05
## ASV9859      3.056918e-04  3.211470e-04  3.374179e-04  3.545500e-04
## ASV0936     -5.760767e-04 -6.014618e-04 -6.278782e-04 -6.553605e-04
## ASV12683    -6.493125e-05 -6.822825e-05 -7.169309e-05 -7.533376e-05
## ASV1293      8.424871e-04  8.789630e-04  9.168597e-04  9.562192e-04
## ASV13055    -8.504813e-05 -8.841971e-05 -9.189055e-05 -9.546020e-05
## ASV17063    -3.647483e-04 -3.806410e-04 -3.971584e-04 -4.143191e-04
## ASV2228      3.646615e-04  3.805465e-04  3.970555e-04  4.142071e-04
## ASV2769     -5.724975e-05 -5.892479e-05 -6.059038e-05 -6.223927e-05
## ASV2803      1.668878e-04  1.736265e-04  1.805887e-04  1.877781e-04
## ASV2896      4.705412e-04  4.920764e-04  5.145700e-04  5.380635e-04
## ASV3062      1.588166e-04  1.672567e-04  1.761740e-04  1.855967e-04
## ASV3107      5.664119e-04  5.922441e-04  6.192077e-04  6.473487e-04
## ASV3265      1.094409e-03  1.141687e-03  1.190797e-03  1.241792e-03
## ASV3666     -2.742632e-05 -2.882065e-05 -3.028849e-05 -3.183393e-05
## ASV4497      2.601023e-04  2.714169e-04  2.831789e-04  2.954023e-04
## ASV6914     -1.318225e-04 -1.378784e-04 -1.441994e-04 -1.507958e-04
## ASV0576     -1.271223e-03 -1.324500e-03 -1.379705e-03 -1.436882e-03
## ASV0673      3.582204e-04  3.755035e-04  3.936138e-04  4.125887e-04
## ASV0772      3.986790e-04  4.165227e-04  4.351197e-04  4.544986e-04
## ASV0862     -3.019544e-04 -3.140103e-04 -3.264432e-04 -3.392553e-04
## ASV0898      3.469017e-04  3.637800e-04  3.814832e-04  4.000510e-04
## ASV0910      7.392551e-04  7.744567e-04  8.113253e-04  8.499382e-04
## ASV0964     -4.634130e-04 -4.830615e-04 -5.034374e-04 -5.245586e-04
## ASV10059     3.484877e-04  3.653217e-04  3.829778e-04  4.014967e-04
## ASV10263    -3.651480e-04 -3.810777e-04 -3.976354e-04 -4.148401e-04
## ASV1088      3.945377e-04  4.135162e-04  4.334179e-04  4.542886e-04
## ASV1101      6.413599e-04  6.698684e-04  6.995468e-04  7.304341e-04
## ASV1183      4.149383e-04  4.337770e-04  4.534272e-04  4.739199e-04
## ASV11956     1.488017e-04  1.545600e-04  1.604865e-04  1.665819e-04
## ASV12774    -6.018614e-05 -6.321299e-05 -6.639383e-05 -6.973633e-05
## ASV1321      1.850258e-04  1.950130e-04  2.055731e-04  2.167407e-04
## ASV13793    -3.650456e-04 -3.809661e-04 -3.975138e-04 -4.147076e-04
## ASV14482    -3.923026e-05 -4.137313e-05 -4.363386e-05 -4.601834e-05
## ASV15483     2.657833e-04  2.780810e-04  2.909334e-04  3.043641e-04
## ASV2062      1.634321e-03  1.707334e-03  1.783398e-03  1.862623e-03
## ASV2132      7.592872e-04  7.944393e-04  8.311747e-04  8.695606e-04
## ASV2413      1.042511e-03  1.087996e-03  1.135290e-03  1.184453e-03
## ASV2490      6.764106e-04  7.051312e-04  7.349213e-04  7.658082e-04
## ASV2594      3.834329e-04  4.007506e-04  4.188207e-04  4.376744e-04
## ASV2822     -3.651992e-04 -3.811344e-04 -3.976982e-04 -4.149096e-04
## ASV2863      6.326504e-04  6.599193e-04  6.882413e-04  7.176473e-04
## ASV2910      8.232847e-04  8.586416e-04  8.953535e-04  9.334591e-04
## ASV2980      2.988775e-04  3.117316e-04  3.250748e-04  3.389201e-04
## ASV3307      3.650545e-04  3.809768e-04  3.975267e-04  4.147231e-04
## ASV3474      6.044956e-04  6.334258e-04  6.637387e-04  6.954993e-04
## ASV3502      1.210711e-03  1.265107e-03  1.321807e-03  1.380899e-03
## ASV4236      5.953548e-04  6.206430e-04  6.468724e-04  6.740669e-04
## ASV4842     -2.016480e-04 -2.106061e-04 -2.199284e-04 -2.296264e-04
## ASV4894     -3.651643e-04 -3.810972e-04 -3.976587e-04 -4.148678e-04
## ASV5290      4.576941e-04  4.782755e-04  4.997272e-04  5.220811e-04
## ASV5501      8.526331e-05  8.909093e-05  9.308510e-05  9.725297e-05
## ASV5795      3.160143e-04  3.308368e-04  3.463434e-04  3.625643e-04
## ASV5987     -3.652056e-04 -3.811429e-04 -3.977091e-04 -4.149235e-04
## ASV6267     -3.651186e-04 -3.810481e-04 -3.976059e-04 -4.148111e-04
## ASV6862      6.884894e-04  7.172568e-04  7.470588e-04  7.779193e-04
## ASV7145      1.237210e-04  1.287082e-04  1.338646e-04  1.391940e-04
## ASV7673     -3.650917e-04 -3.810185e-04 -3.975734e-04 -4.147755e-04
## ASV7789      1.528492e-04  1.611580e-04  1.699519e-04  1.792611e-04
## ASV7809     -3.508078e-05 -3.579446e-05 -3.645992e-05 -3.706845e-05
## ASV8002     -3.650388e-04 -3.809620e-04 -3.975132e-04 -4.147113e-04
## ASV8205      2.168922e-04  2.267239e-04  2.369848e-04  2.476928e-04
## ASV9155     -2.735837e-04 -2.854032e-04 -2.976776e-04 -3.104196e-04
## ASV9221     -2.999039e-05 -3.033005e-05 -3.059032e-05 -3.075969e-05
## ASV9311     -3.649296e-04 -3.808437e-04 -3.973852e-04 -4.145729e-04
## ASV9557     -3.648427e-04 -3.807491e-04 -3.972821e-04 -4.144608e-04
## ASV9936     -3.647558e-04 -3.806545e-04 -3.971791e-04 -4.143487e-04
## ASV1445      8.693044e-04  9.093048e-04  9.510850e-04  9.947188e-04
## ASV4232      7.472609e-04  7.826976e-04  8.198120e-04  8.586835e-04
## ASV6479      1.660951e-05  1.893730e-05  2.150623e-05  2.433786e-05
## ASV0142     -1.830005e-03 -1.908401e-03 -1.989781e-03 -2.074229e-03
## ASV0378     -5.901872e-04 -6.146378e-04 -6.399350e-04 -6.660934e-04
## ASV1122      1.149616e-03  1.202545e-03  1.257826e-03  1.315557e-03
## ASV0123     -1.791359e-03 -1.867987e-03 -1.947521e-03 -2.030042e-03
## ASV2064      1.775632e-04  1.845174e-04  1.916787e-04  1.990478e-04
## ASV4459     -1.984893e-04 -2.070067e-04 -2.158474e-04 -2.250201e-04
## ASV0448      3.522369e-04  3.703289e-04  3.893872e-04  4.094649e-04
## ASV0397      8.522425e-04  8.909269e-04  9.312822e-04  9.733733e-04
## ASV0485      1.179791e-03  1.232356e-03  1.287114e-03  1.344143e-03
## ASV1566      9.968160e-04  1.041916e-03  1.088949e-03  1.137990e-03
## ASV1365      6.479372e-04  6.774224e-04  7.081878e-04  7.402834e-04
## ASV1065      1.324997e-03  1.385130e-03  1.447861e-03  1.513291e-03
## ASV0722     -2.304532e-05 -2.375946e-05 -2.447974e-05 -2.520482e-05
## ASV12660    -6.000472e-04 -6.255496e-04 -6.520076e-04 -6.794468e-04
## ASV0223     -2.224642e-05 -2.303604e-05 -2.383737e-05 -2.464850e-05
## ASV0229      6.011478e-04  6.291384e-04  6.584037e-04  6.889993e-04
## ASV0877     -2.110085e-04 -2.193751e-04 -2.279994e-04 -2.368829e-04
## ASV0983      1.197490e-03  1.250242e-03  1.305134e-03  1.362237e-03
## ASV0626     -3.651245e-04 -3.789472e-04 -3.931318e-04 -4.076737e-04
## ASV4146     -6.365690e-05 -6.629537e-05 -6.902679e-05 -7.185328e-05
## ASV4175     -7.445150e-04 -7.781331e-04 -8.131857e-04 -8.497267e-04
## ASV2082     -6.876462e-05 -7.309686e-05 -7.773219e-05 -8.269335e-05
## ASV2272      5.459921e-04  5.713512e-04  5.978624e-04  6.255760e-04
## ASV2245     -6.523849e-04 -6.821565e-04 -7.132257e-04 -7.456436e-04
## ASV0590     -4.194718e-04 -4.404120e-04 -4.624260e-04 -4.855700e-04
## ASV0217     -5.356678e-04 -5.546631e-04 -5.740182e-04 -5.937092e-04
## ASV0416      5.715908e-04  5.947914e-04  6.187586e-04  6.435029e-04
## ASV1056      7.454496e-04  7.811962e-04  8.186529e-04  8.578996e-04
## ASV7777     -6.438118e-04 -6.729926e-04 -7.034312e-04 -7.351766e-04
## ASV0455      1.376912e-04  1.445185e-04  1.516855e-04  1.592082e-04
## ASV0604      1.626636e-04  1.717450e-04  1.813645e-04  1.915547e-04
## ASV6100     -5.963189e-04 -6.234909e-04 -6.518477e-04 -6.814366e-04
## ASV11359    -6.608996e-04 -6.904689e-04 -7.212754e-04 -7.533636e-04
## ASV6604      4.815298e-04  5.040970e-04  5.277052e-04  5.524009e-04
## ASV5004     -3.871966e-04 -4.044739e-04 -4.224712e-04 -4.412143e-04
## ASV1483     -3.592167e-04 -3.754034e-04 -3.922782e-04 -4.098671e-04
## ASV9773     -7.622665e-04 -7.968609e-04 -8.329505e-04 -8.705937e-04
## ASV4059      8.609605e-05  9.107370e-05  9.636243e-05  1.019827e-04
## ASV1193      1.236956e-03  1.292765e-03  1.350956e-03  1.411616e-03
## ASV4610     -8.310087e-05 -8.491095e-05 -8.663760e-05 -8.826534e-05
## ASV0742     -4.259610e-04 -4.422714e-04 -4.590257e-04 -4.762198e-04
## ASV1502     -1.888138e-05 -2.065755e-05 -2.259004e-05 -2.469150e-05
## ASV0195     -1.514025e-04 -1.593943e-04 -1.678238e-04 -1.767150e-04
## ASV1213      3.733632e-04  3.887275e-04  4.046162e-04  4.210380e-04
## ASV1648     -5.623941e-04 -5.877846e-04 -6.142624e-04 -6.418694e-04
## ASV6984     -4.240176e-04 -4.434091e-04 -4.636537e-04 -4.847862e-04
## ASV0396     -2.668313e-04 -2.748787e-04 -2.829245e-04 -2.909401e-04
## ASV4297      6.157649e-04  6.420138e-04  6.692519e-04  6.975060e-04
## ASV2622      1.415107e-03  1.476502e-03  1.540306e-03  1.606594e-03
## ASV3512      2.445049e-04  2.573572e-04  2.709268e-04  2.852563e-04
## ASV2411      5.128036e-04  5.372305e-04  5.628148e-04  5.896100e-04
## ASV2291     -1.402581e-04 -1.477373e-04 -1.556413e-04 -1.639956e-04
## ASV0807      6.181425e-04  6.488435e-04  6.811000e-04  7.149914e-04
## ASV1292      3.193392e-04  3.332142e-04  3.476387e-04  3.626306e-04
## ASV1035      1.425878e-04  1.482604e-04  1.541165e-04  1.601592e-04
## ASV0070     -3.119105e-04 -3.234717e-04 -3.352978e-04 -3.473786e-04
## ASV0255      1.395858e-04  1.458254e-04  1.523207e-04  1.590797e-04
## ASV0057     -1.434947e-03 -1.495093e-03 -1.557400e-03 -1.621916e-03
## ASV0077     -1.902249e-04 -1.965826e-04 -2.030127e-04 -2.095006e-04
## ASV0625      1.445419e-03  1.507434e-03  1.571816e-03  1.638630e-03
## ASV2464      6.909395e-04  7.199235e-04  7.499639e-04  7.810867e-04
## ASV1315      1.326940e-03  1.389483e-03  1.454937e-03  1.523432e-03
## ASV2673      9.723221e-04  1.018694e-03  1.067276e-03  1.118173e-03
## ASV2161      4.025124e-04  4.218674e-04  4.421587e-04  4.634319e-04
## ASV0337     -6.156688e-04 -6.429702e-04 -6.713925e-04 -7.009740e-04
## ASV7680     -7.349146e-04 -7.684399e-04 -8.034290e-04 -8.399402e-04
## ASV0611      1.617258e-03  1.692558e-03  1.771290e-03  1.853607e-03
## ASV3118     -5.476568e-04 -5.729835e-04 -5.994452e-04 -6.270893e-04
## ASV1284      5.773967e-04  6.040543e-04  6.319051e-04  6.609994e-04
## ASV0889      4.289906e-04  4.479673e-04  4.677261e-04  4.882952e-04
## ASV4649     -4.536019e-04 -4.740819e-04 -4.954365e-04 -5.176986e-04
## ASV1108     -6.015623e-04 -6.304526e-04 -6.607343e-04 -6.924740e-04
## ASV0738     -3.775363e-05 -3.541957e-05 -3.262800e-05 -2.933082e-05
## ASV0473      9.067203e-05  9.489673e-05  9.931754e-05  1.039438e-04
## ASV0598     -6.282773e-04 -6.542830e-04 -6.811952e-04 -7.090315e-04
## ASV0429      1.039379e-03  1.085381e-03  1.133263e-03  1.183088e-03
## ASV1549      1.086645e-03  1.138733e-03  1.193322e-03  1.250533e-03
## ASV1203      7.897061e-04  8.250139e-04  8.617991e-04  9.001149e-04
## ASV4532      2.818777e-05  2.896288e-05  2.973512e-05  3.050237e-05
## ASV0274     -7.638669e-04 -7.957219e-04 -8.287112e-04 -8.628593e-04
## ASV0163     -1.086663e-03 -1.131632e-03 -1.178167e-03 -1.226301e-03
## ASV1298      4.415418e-04  4.598470e-04  4.787989e-04  4.984116e-04
## ASV9424     -9.802548e-04 -1.025440e-03 -1.072641e-03 -1.121944e-03
## ASV0412      1.479938e-03  1.545731e-03  1.614253e-03  1.685601e-03
## ASV0284      6.435520e-04  6.706896e-04  6.988235e-04  7.279781e-04
## ASV0620     -5.184575e-04 -5.434269e-04 -5.695991e-04 -5.970310e-04
## ASV0153     -1.062021e-03 -1.111893e-03 -1.164069e-03 -1.218649e-03
## ASV0498      1.511923e-04  1.610130e-04  1.715091e-04  1.827267e-04
## ASV0097      7.659398e-04  8.023670e-04  8.405232e-04  8.804900e-04
## ASV0104     -3.423242e-03 -3.576865e-03 -3.736972e-03 -3.903803e-03
## ASV1282      6.042413e-04  6.320273e-04  6.610434e-04  6.913393e-04
## ASV3883     -3.583868e-04 -3.754707e-04 -3.933617e-04 -4.120966e-04
## ASV0801      3.645255e-04  3.824925e-04  4.013550e-04  4.211573e-04
## ASV1611     -1.337900e-03 -1.399560e-03 -1.463971e-03 -1.531246e-03
## ASV0227     -5.077438e-04 -5.328833e-04 -5.592900e-04 -5.870280e-04
## ASV0833      5.444248e-04  5.712794e-04  5.994759e-04  6.290809e-04
## ASV0718      1.235901e-03  1.292078e-03  1.350692e-03  1.411840e-03
## ASV1139      4.209828e-04  4.375259e-04  4.545535e-04  4.720644e-04
## ASV0766     -3.276504e-04 -3.417449e-04 -3.563784e-04 -3.715659e-04
## ASV2091      1.604196e-03  1.672745e-03  1.743888e-03  1.817696e-03
## ASV1238     -7.850915e-05 -7.995135e-05 -8.126985e-05 -8.244422e-05
## ASV9193     -1.706751e-04 -1.801525e-04 -1.901887e-04 -2.008177e-04
## ASV0290     -1.530841e-04 -1.611739e-04 -1.697059e-04 -1.787038e-04
## ASV0231      1.299373e-03  1.357494e-03  1.418055e-03  1.481147e-03
## ASV0185      3.105978e-04  3.309631e-04  3.527701e-04  3.761241e-04
## ASV2330      3.680439e-04  3.839146e-04  4.003991e-04  4.175155e-04
## ASV3119     -4.611299e-04 -4.845941e-04 -5.092976e-04 -5.353080e-04
## ASV2368     -6.123399e-04 -6.414092e-04 -6.718536e-04 -7.037376e-04
## ASV0122     -4.522118e-04 -4.712337e-04 -4.909499e-04 -5.113772e-04
## ASV1044      8.539655e-04  8.955204e-04  9.391191e-04  9.848625e-04
## ASV0160     -1.105008e-03 -1.150552e-03 -1.197661e-03 -1.246363e-03
## ASV0326      7.531311e-04  7.873735e-04  8.230990e-04  8.603653e-04
## ASV1388      1.310698e-03  1.369601e-03  1.430998e-03  1.494981e-03
## ASV0792      1.467295e-03  1.531720e-03  1.598736e-03  1.668426e-03
## ASV0036     -9.563580e-04 -1.000856e-03 -1.047370e-03 -1.095987e-03
## ASV2125      1.531583e-03  1.600339e-03  1.672000e-03  1.746673e-03
## ASV1075      3.034392e-04  3.179756e-04  3.332099e-04  3.491758e-04
## ASV0390      3.135055e-04  3.298214e-04  3.470337e-04  3.651945e-04
## ASV3790     -1.245758e-03 -1.302954e-03 -1.362681e-03 -1.425041e-03
## ASV1535     -1.114670e-04 -1.174043e-04 -1.236796e-04 -1.303134e-04
## ASV0263      2.563328e-04  2.680208e-04  2.802181e-04  2.929448e-04
## ASV0675      2.077355e-03  2.175307e-03  2.277822e-03  2.385105e-03
## ASV3348      2.070572e-04  2.174601e-04  2.284045e-04  2.399199e-04
## ASV0058     -1.923868e-03 -2.009572e-03 -2.098832e-03 -2.191774e-03
## ASV4142      4.801884e-04  5.013499e-04  5.233631e-04  5.462550e-04
## ASV0059     -1.655428e-03 -1.728862e-03 -1.805314e-03 -1.884887e-03
## ASV0013     -3.474276e-03 -3.630161e-03 -3.792628e-03 -3.961920e-03
## ASV0033     -1.043462e-03 -1.092205e-03 -1.143177e-03 -1.196474e-03
## ASV4354     -4.355403e-04 -4.543614e-04 -4.739212e-04 -4.942435e-04
## ASV0022     -1.098758e-03 -1.149896e-03 -1.203352e-03 -1.259228e-03
## ASV0134     -2.838430e-04 -2.979381e-04 -3.127460e-04 -3.283028e-04
## ASV0415     -1.958323e-04 -2.022488e-04 -2.087341e-04 -2.152743e-04
## ASV10103    -7.632369e-04 -7.982974e-04 -8.349094e-04 -8.731361e-04
## ASV1613      1.203916e-03  1.256666e-03  1.311527e-03  1.368564e-03
## ASV0135     -2.698015e-05 -2.499885e-05 -2.264346e-05 -1.987411e-05
## ASV0469     -1.497961e-03 -1.563313e-03 -1.631264e-03 -1.701895e-03
## ASV0471      9.733990e-04  1.017682e-03  1.063884e-03  1.112083e-03
## ASV0451     -2.828090e-04 -2.970652e-04 -3.120636e-04 -3.278439e-04
## ASV0747      3.973452e-04  4.169699e-04  4.375797e-04  4.592242e-04
## ASV1314     -6.034088e-04 -6.328930e-04 -6.638453e-04 -6.963405e-04
## ASV0425     -1.679407e-03 -1.750843e-03 -1.824949e-03 -1.901791e-03
## ASV0559     -9.551516e-04 -9.958483e-04 -1.038087e-03 -1.081913e-03
## ASV0148     -1.030541e-03 -1.073874e-03 -1.118774e-03 -1.165276e-03
## ASV0129     -4.890472e-04 -5.076368e-04 -5.267082e-04 -5.462523e-04
## ASV1072      4.965229e-04  5.170679e-04  5.383231e-04  5.603008e-04
## ASV2390      3.541077e-04  3.687468e-04  3.838884e-04  3.995403e-04
## ASV0548      1.125782e-03  1.177372e-03  1.231236e-03  1.287467e-03
## ASV0168     -1.659082e-03 -1.732078e-03 -1.808032e-03 -1.887042e-03
## ASV0066     -1.237063e-03 -1.292039e-03 -1.349286e-03 -1.408882e-03
## ASV0468     -4.610612e-04 -4.819157e-04 -5.036669e-04 -5.263495e-04
## ASV0172     -2.217394e-04 -2.284531e-04 -2.351616e-04 -2.418396e-04
## ASV0236     -5.931395e-04 -6.153497e-04 -6.381059e-04 -6.613945e-04
## ASV0250      9.510581e-05  1.045652e-04  1.148928e-04  1.261623e-04
## ASV0338     -5.856596e-05 -5.854750e-05 -5.830518e-05 -5.781311e-05
## ASV0450     -5.207863e-06 -5.385613e-06 -5.565879e-06 -5.748395e-06
## ASV0377      1.368405e-03  1.430051e-03  1.494321e-03  1.561314e-03
## ASV1022      3.842114e-04  4.018177e-04  4.202040e-04  4.394028e-04
## ASV6174     -9.109715e-05 -9.498462e-05 -9.902367e-05 -1.032195e-04
## ASV0786      1.439465e-04  1.496884e-04  1.556125e-04  1.617207e-04
## ASV0053     -1.650997e-03 -1.725749e-03 -1.803716e-03 -1.885021e-03
## ASV0697     -4.552488e-04 -4.739887e-04 -4.933732e-04 -5.134141e-04
## ASV0785      1.227240e-03  1.282649e-03  1.340427e-03  1.400664e-03
## ASV1967     -7.850021e-04 -8.183887e-04 -8.530340e-04 -8.889729e-04
## ASV0385     -3.582208e-04 -3.727155e-04 -3.876855e-04 -4.031368e-04
## ASV0295      3.634741e-05  4.075796e-05  4.560829e-05  5.093752e-05
## ASV0072     -1.278971e-03 -1.333623e-03 -1.390333e-03 -1.449153e-03
## ASV0157     -5.149238e-04 -5.355084e-04 -5.567275e-04 -5.785827e-04
## ASV0501      6.235960e-04  6.537436e-04  6.853597e-04  7.185158e-04
## ASV10729    -1.013042e-03 -1.059499e-03 -1.108004e-03 -1.158641e-03
## ASV1470      4.670310e-04  4.872348e-04  5.082228e-04  5.300179e-04
## ASV0050     -3.261966e-03 -3.406759e-03 -3.557522e-03 -3.714463e-03
## ASV0411     -6.973989e-05 -7.159390e-05 -7.341066e-05 -7.517854e-05
## ASV0549      6.457657e-04  6.767093e-04  7.091395e-04  7.431273e-04
## ASV0184      3.839754e-04  4.013351e-04  4.194462e-04  4.383390e-04
## ASV0705      4.727678e-04  4.948935e-04  5.180279e-04  5.422140e-04
## ASV1715      1.173699e-03  1.227160e-03  1.282953e-03  1.341168e-03
## ASV0603      1.444592e-04  1.514763e-04  1.588423e-04  1.665757e-04
## ASV0826      3.782731e-04  3.942625e-04  4.108398e-04  4.280191e-04
## ASV0034     -1.460708e-03 -1.524374e-03 -1.590553e-03 -1.659322e-03
## ASV0838      3.093080e-04  3.228581e-04  3.369436e-04  3.515801e-04
## ASV0614     -8.340162e-04 -8.707292e-04 -9.089298e-04 -9.486677e-04
## ASV0014     -3.165598e-03 -3.306430e-03 -3.453099e-03 -3.605813e-03
## ASV0585     -2.037493e-04 -2.132015e-04 -2.230789e-04 -2.333992e-04
## ASV0016     -3.237918e-03 -3.382115e-03 -3.532301e-03 -3.688691e-03
## ASV5394     -8.327411e-04 -8.707816e-04 -9.104850e-04 -9.519173e-04
## ASV0666      6.971801e-04  7.281396e-04  7.603756e-04  7.939324e-04
## ASV2085      2.391770e-04  2.468996e-04  2.546874e-04  2.625213e-04
## ASV0003     -2.954066e-03 -3.085001e-03 -3.221320e-03 -3.363210e-03
## ASV0346     -1.804834e-05 -1.572786e-05 -1.303663e-05 -9.938137e-06
## ASV0267     -4.476693e-04 -4.658057e-04 -4.845285e-04 -5.038435e-04
## ASV0353      6.752723e-04  7.089836e-04  7.444241e-04  7.816846e-04
## ASV2419      8.298242e-04  8.662630e-04  9.041727e-04  9.436024e-04
## ASV0447      4.420438e-04  4.654299e-04  4.901121e-04  5.161641e-04
## ASV0654      1.321264e-03  1.382254e-03  1.445962e-03  1.512500e-03
## ASV0151      2.307694e-04  2.435313e-04  2.570559e-04  2.713923e-04
## ASV0065     -1.196312e-03 -1.249631e-03 -1.305164e-03 -1.362989e-03
## ASV0527      8.675478e-04  9.063794e-04  9.468416e-04  9.889938e-04
## ASV4055     -3.389792e-04 -3.553744e-04 -3.725726e-04 -3.906140e-04
## ASV0166     -9.760317e-04 -1.017865e-03 -1.061293e-03 -1.106360e-03
## ASV0417     -8.354154e-04 -8.721451e-04 -9.103617e-04 -9.501152e-04
## ASV0078     -6.595311e-04 -6.875846e-04 -7.166771e-04 -7.468334e-04
## ASV0322     -8.025748e-04 -8.367428e-04 -8.721837e-04 -9.089292e-04
## ASV0156     -1.055139e-03 -1.101247e-03 -1.149197e-03 -1.199050e-03
## ASV0648     -9.845916e-04 -1.030231e-03 -1.077927e-03 -1.127767e-03
## ASV0407      8.597103e-05  9.077945e-05  9.587771e-05  1.012843e-04
## ASV2030     -1.926119e-04 -2.002151e-04 -2.080617e-04 -2.161558e-04
## ASV0300      5.995487e-04  6.291454e-04  6.602298e-04  6.928772e-04
## ASV1150     -6.181802e-05 -6.364162e-05 -6.545465e-05 -6.724872e-05
## ASV0958      6.259112e-04  6.568776e-04  6.894184e-04  7.236166e-04
## ASV0216     -9.899868e-04 -1.032174e-03 -1.075956e-03 -1.121377e-03
## ASV0446      1.464854e-03  1.534517e-03  1.607463e-03  1.683842e-03
## ASV0367     -4.835868e-04 -5.051399e-04 -5.275916e-04 -5.509745e-04
## ASV0200     -9.087741e-04 -9.499168e-04 -9.928341e-04 -1.037596e-03
## ASV0334     -4.207852e-04 -4.359068e-04 -4.513412e-04 -4.670729e-04
## ASV1311      6.314697e-04  6.592407e-04  6.881323e-04  7.181813e-04
## ASV0458      6.865432e-04  7.171538e-04  7.490470e-04  7.822704e-04
## ASV1371      2.284657e-05  2.402940e-05  2.527645e-05  2.659131e-05
## ASV0418      8.454941e-04  8.837497e-04  9.236537e-04  9.652705e-04
## ASV0004      9.996900e-04  1.044549e-03  1.091301e-03  1.140018e-03
## ASV1943      7.188899e-04  7.502913e-04  7.829545e-04  8.169221e-04
## ASV1495     -2.063603e-04 -2.178164e-04 -2.299550e-04 -2.428191e-04
## ASV0901     -1.165739e-03 -1.220286e-03 -1.277343e-03 -1.337019e-03
## ASV0628      6.525560e-04  6.807440e-04  7.100197e-04  7.404136e-04
## ASV0400      2.618657e-04  2.732045e-04  2.849818e-04  2.972101e-04
## ASV0116     -9.096416e-04 -9.531244e-04 -9.986838e-04 -1.046418e-03
## ASV0788      7.279105e-04  7.609870e-04  7.954974e-04  8.314979e-04
## ASV0117      4.902394e-04  5.142811e-04  5.395243e-04  5.660301e-04
## ASV3137      1.248952e-04  1.303118e-04  1.359413e-04  1.417901e-04
## ASV0001      1.167221e-03  1.216988e-03  1.268626e-03  1.322184e-03
## ASV1651      7.787404e-04  8.120063e-04  8.465347e-04  8.823612e-04
## ASV1692      8.847426e-04  9.269165e-04  9.710930e-04  1.017365e-03
## ASV0660      4.645802e-04  4.833062e-04  5.026257e-04  5.225424e-04
## ASV0508      5.030561e-05  5.180473e-05  5.330678e-05  5.480756e-05
## ASV1660     -3.696558e-04 -3.877247e-04 -4.066826e-04 -4.265727e-04
## ASV0233      2.068506e-04  2.171053e-04  2.278850e-04  2.392177e-04
## ASV1343     -8.718482e-04 -9.119500e-04 -9.538349e-04 -9.975771e-04
## ASV0209      7.700055e-04  8.024860e-04  8.361597e-04  8.710561e-04
## ASV0193     -1.015676e-03 -1.059644e-03 -1.105330e-03 -1.152786e-03
## ASV0357     -3.524999e-05 -3.475441e-05 -3.404471e-05 -3.309502e-05
## ASV0198      2.256600e-04  2.361233e-04  2.470599e-04  2.584906e-04
## ASV0007      1.106456e-03  1.153632e-03  1.202581e-03  1.253350e-03
## ASV1772     -1.139859e-04 -1.188762e-04 -1.239477e-04 -1.292040e-04
## ASV0009      1.041520e-03  1.085746e-03  1.131618e-03  1.179178e-03
## ASV0006      3.960922e-04  4.110463e-04  4.263823e-04  4.420932e-04
## ASV0011     -1.224483e-03 -1.281277e-03 -1.340636e-03 -1.402669e-03
## ASV0015      8.415735e-04  8.794214e-04  9.188721e-04  9.599849e-04
## ASV0017      8.892685e-04  9.291273e-04  9.706638e-04  1.013940e-03
## ASV0235     -7.135764e-04 -7.465253e-04 -7.809439e-04 -8.168928e-04
## ASV0382      1.613640e-04  1.713968e-04  1.820905e-04  1.934883e-04
## ASV2357      1.079005e-03  1.128417e-03  1.180009e-03  1.233870e-03
## ASV0567     -7.660927e-04 -7.998661e-04 -8.350227e-04 -8.716115e-04
## ASV0165      8.496763e-04  8.879640e-04  9.278836e-04  9.694967e-04
## ASV0005      1.689808e-03  1.764156e-03  1.841506e-03  1.921955e-03
## ASV0384     -5.834619e-05 -5.913773e-05 -5.979127e-05 -6.028558e-05
## ASV0002      3.845552e-04  4.033367e-04  4.230512e-04  4.437462e-04
## ASV3017      9.770693e-04  1.019414e-03  1.063415e-03  1.109120e-03
## ASV0091      3.940971e-04  4.126722e-04  4.321102e-04  4.524497e-04
## ASV0186     -1.039953e-03 -1.087583e-03 -1.137306e-03 -1.189205e-03
## ASV0370      1.107588e-04  1.162233e-04  1.219634e-04  1.279931e-04
## ASV0018      1.764533e-03  1.842531e-03  1.923711e-03  2.008181e-03
## ASV1377      1.536408e-03  1.604029e-03  1.674390e-03  1.747584e-03
## ASV0019      1.767307e-03  1.845469e-03  1.926824e-03  2.011480e-03
## ASV0023      8.754010e-05  8.863199e-05  8.952023e-05  9.017602e-05
## ASV2194      5.966430e-04  6.247261e-04  6.541169e-04  6.848751e-04
## ASV1155     -4.838407e-05 -4.914466e-05 -4.980537e-05 -5.035047e-05
## ASV0510     -6.136730e-04 -6.380122e-04 -6.630984e-04 -6.889356e-04
## ASV2371     -6.162314e-04 -6.419472e-04 -6.685908e-04 -6.961846e-04
## ASV0024      1.526575e-06 -1.282266e-06 -4.463080e-06 -8.051214e-06
## ASV2452      8.128916e-04  8.474064e-04  8.831972e-04  9.202946e-04
## ASV2332      7.777967e-05  8.389325e-05  9.048377e-05  9.758606e-05
## ASV2591      7.377599e-05  7.968165e-05  8.604951e-05  9.291291e-05
## ASV0521      1.176247e-03  1.231706e-03  1.289749e-03  1.350492e-03
## ASV5542      3.724790e-04  3.905554e-04  4.095048e-04  4.293678e-04
## ASV0336     -5.346528e-04 -5.585358e-04 -5.834186e-04 -6.093376e-04
## ASV10102     8.085681e-04  8.460365e-04  8.851873e-04  9.260906e-04
## ASV16823    -5.921919e-04 -6.165597e-04 -6.417789e-04 -6.678679e-04
## ASV3104      5.920606e-04  6.164174e-04  6.416249e-04  6.677013e-04
## ASV0781      2.969811e-04  3.099866e-04  3.235102e-04  3.375681e-04
## ASV10899     3.246645e-04  3.418431e-04  3.599726e-04  3.791072e-04
## ASV11222    -5.919847e-04 -6.163362e-04 -6.415380e-04 -6.676086e-04
## ASV11327    -5.918534e-04 -6.161940e-04 -6.413842e-04 -6.674421e-04
## ASV12458    -5.917222e-04 -6.160519e-04 -6.412303e-04 -6.672757e-04
## ASV1636     -4.815657e-04 -5.011490e-04 -5.213907e-04 -5.423021e-04
## ASV1890     -5.967074e-04 -6.218222e-04 -6.478705e-04 -6.748785e-04
## ASV2898      1.324111e-03  1.382156e-03  1.442530e-03  1.505307e-03
## ASV8328     -6.335567e-05 -6.319527e-05 -6.277297e-05 -6.205835e-05
## ASV0709     -1.086783e-03 -1.134706e-03 -1.184572e-03 -1.236443e-03
## ASV0856      1.905316e-04  2.002170e-04  2.104094e-04  2.211355e-04
## ASV0909     -4.157323e-04 -4.307673e-04 -4.461203e-04 -4.617767e-04
## ASV0937     -8.661830e-04 -9.059299e-04 -9.474482e-04 -9.908135e-04
## ASV11390    -5.914502e-04 -6.157579e-04 -6.409128e-04 -6.669329e-04
## ASV11966     3.430957e-04  3.603041e-04  3.783921e-04  3.974045e-04
## ASV12990     1.735120e-04  1.815276e-04  1.898930e-04  1.986208e-04
## ASV14797     6.269801e-04  6.537653e-04  6.815601e-04  7.103912e-04
## ASV14904    -5.914270e-04 -6.157338e-04 -6.408878e-04 -6.669071e-04
## ASV15304     1.970399e-04  2.079408e-04  2.194739e-04  2.316762e-04
## ASV16696    -5.913293e-04 -6.156288e-04 -6.407750e-04 -6.667862e-04
## ASV1690      3.560670e-04  3.743580e-04  3.936098e-04  4.138721e-04
## ASV2029      1.712080e-03  1.788104e-03  1.867270e-03  1.949688e-03
## ASV2834      9.308208e-04  9.732034e-04  1.017435e-03  1.063591e-03
## ASV4003      3.059773e-04  3.227261e-04  3.404434e-04  3.591871e-04
## ASV4064      6.627253e-04  6.936682e-04  7.260166e-04  7.598299e-04
## ASV4294      2.547396e-04  2.684622e-04  2.829640e-04  2.982908e-04
## ASV4609     -1.623332e-05 -1.631712e-05 -1.635451e-05 -1.634022e-05
## ASV6283     -5.913566e-04 -6.156620e-04 -6.408150e-04 -6.668340e-04
## ASV6491     -5.912256e-04 -6.155201e-04 -6.406614e-04 -6.666678e-04
## ASV7453      2.796310e-04  2.945711e-04  3.103451e-04  3.270004e-04
## ASV7959      8.092378e-05  8.683570e-05  9.318814e-05  1.000125e-04
## ASV8219      5.911558e-04  6.154462e-04  6.405834e-04  6.665857e-04
## ASV8547     -5.910249e-04 -6.153044e-04 -6.404299e-04 -6.664196e-04
## ASV9319      4.367141e-04  4.574014e-04  4.790543e-04  5.017161e-04
## ASV9382     -5.909541e-04 -6.152284e-04 -6.403485e-04 -6.663324e-04
## ASV11516    -5.908232e-04 -6.150867e-04 -6.401951e-04 -6.661665e-04
## ASV14377    -5.906924e-04 -6.149451e-04 -6.400418e-04 -6.660006e-04
## ASV1867      9.317561e-04  9.749484e-04  1.020083e-03  1.067241e-03
## ASV1895     -1.985130e-04 -2.064560e-04 -2.146590e-04 -2.231267e-04
## ASV3168      3.803645e-04  3.966956e-04  4.136374e-04  4.312043e-04
## ASV4449      7.507391e-04  7.827108e-04  8.159011e-04  8.503462e-04
## ASV6596      4.819601e-04  5.062645e-04  5.318327e-04  5.587322e-04
## ASV7492     -1.936343e-04 -1.995930e-04 -2.055776e-04 -2.115716e-04
## ASV9854     -2.976712e-04 -3.094565e-04 -3.216178e-04 -3.341604e-04
## ASV6296      5.904396e-04  6.146730e-04  6.397493e-04  6.656865e-04
## ASV4201      2.521802e-04  2.669252e-04  2.825869e-04  2.992232e-04
## ASV0552      1.562724e-03  1.635470e-03  1.711518e-03  1.791010e-03
## ASV3671     -9.978339e-05 -1.023119e-04 -1.047930e-04 -1.072137e-04
## ASV3529     -9.927766e-05 -1.011303e-04 -1.028517e-04 -1.044216e-04
## ASV1060      3.963477e-04  4.150510e-04  4.346329e-04  4.551348e-04
## ASV0239     -8.305761e-04 -8.649687e-04 -9.005616e-04 -9.373781e-04
## ASV5711     -7.731191e-04 -8.059557e-04 -8.400340e-04 -8.753899e-04
## ASV4152     -1.043786e-03 -1.089722e-03 -1.137531e-03 -1.187280e-03
## ASV1461      9.064365e-04  9.444302e-04  9.837909e-04  1.024549e-03
## ASV2877      7.609503e-04  7.944684e-04  8.293386e-04  8.656045e-04
## ASV0012      6.021635e-04  6.310955e-04  6.614209e-04  6.932063e-04
## ASV9823      1.949090e-04  2.026082e-04  2.105366e-04  2.186940e-04
## ASV0008      6.526230e-04  6.836097e-04  7.160595e-04  7.500404e-04
## ASV7832     -6.360431e-04 -6.636178e-04 -6.922879e-04 -7.220901e-04
## ASV1915      6.759219e-05  7.174100e-05  7.615111e-05  8.083796e-05
## ASV0055      4.470691e-04  4.670570e-04  4.878791e-04  5.095651e-04
## ASV0032      1.060409e-03  1.106311e-03  1.154005e-03  1.203547e-03
## ASV2977     -8.783482e-04 -9.169494e-04 -9.571193e-04 -9.989117e-04
## ASV0466      8.728493e-04  9.098797e-04  9.482912e-04  9.881201e-04
## ASV3866      9.664200e-04  1.010988e-03  1.057545e-03  1.106173e-03
## ASV0040      1.297574e-03  1.358363e-03  1.421950e-03  1.488457e-03
## ASV0496     -1.008076e-04 -1.077918e-04 -1.152882e-04 -1.233345e-04
## ASV0052      1.527606e-03  1.595295e-03  1.665762e-03  1.739103e-03
## ASV3828     -9.317285e-04 -9.725002e-04 -1.014923e-03 -1.059054e-03
## ASV1930      5.944771e-04  6.213262e-04  6.493117e-04  6.784744e-04
## ASV2126      9.582811e-04  1.001043e-03  1.045584e-03  1.091968e-03
## ASV0793      6.150728e-04  6.454678e-04  6.773913e-04  7.109204e-04
## ASV0299     -3.701280e-04 -3.843699e-04 -3.990175e-04 -4.140711e-04
## ASV0208      9.291235e-04  9.733447e-04  1.019663e-03  1.068178e-03
## ASV0511     -4.463832e-04 -4.632514e-04 -4.805511e-04 -4.982743e-04
## ASV1123     -6.111475e-04 -6.361917e-04 -6.620890e-04 -6.888544e-04
## ASV0099     -3.452088e-04 -3.599810e-04 -3.752989e-04 -3.911739e-04
## ASV0752     -8.901277e-05 -9.415423e-05 -9.960417e-05 -1.053807e-04
## ASV0883      1.944692e-05  2.103902e-05  2.275780e-05  2.461254e-05
## ASV0683      8.276552e-04  8.668307e-04  9.078392e-04  9.507637e-04
## ASV4117     -9.399657e-04 -9.812446e-04 -1.024206e-03 -1.068909e-03
## ASV2172      3.596389e-04  3.760208e-04  3.931137e-04  4.109456e-04
## ASV0330     -6.543016e-04 -6.842037e-04 -7.154131e-04 -7.479816e-04
## ASV0728      6.380340e-04  6.683906e-04  7.001706e-04  7.334375e-04
## ASV0499      1.249255e-03  1.308491e-03  1.370519e-03  1.435470e-03
## ASV0120     -1.344216e-03 -1.404613e-03 -1.467557e-03 -1.533141e-03
## ASV1446      8.640466e-05  8.843086e-05  9.038274e-05  9.224412e-05
## ASV17171    -8.964216e-04 -9.360665e-04 -9.773523e-04 -1.020339e-03
## ASV0533      2.695811e-04  2.826840e-04  2.964322e-04  3.108579e-04
## ASV2495     -3.773040e-04 -3.951466e-04 -4.138398e-04 -4.334253e-04
## ASV5582      2.990274e-04  3.108433e-04  3.230169e-04  3.355496e-04
## ASV1488      3.034845e-04  3.180030e-04  3.332112e-04  3.491406e-04
## ASV0682      8.691151e-04  9.102620e-04  9.533408e-04  9.984402e-04
## ASV0068     -7.570107e-05 -8.098337e-05 -8.665065e-05 -9.273034e-05
## ASV1987     -4.889921e-04 -5.134336e-04 -5.391246e-04 -5.661297e-04
## ASV0035      1.176455e-04  1.196701e-04  1.214766e-04  1.230286e-04
## ASV7192     -5.865688e-04 -6.111553e-04 -6.366352e-04 -6.630301e-04
## ASV0873      6.825248e-05  6.975817e-05  7.120285e-05  7.257518e-05
## ASV4749      1.206407e-05  9.579781e-06  6.719287e-06  3.444905e-06
## ASV2174      5.512537e-04  5.738487e-04  5.972174e-04  6.213741e-04
## ASV1476     -5.082663e-04 -5.315376e-04 -5.558473e-04 -5.812403e-04
## ASV0740     -1.260799e-03 -1.320170e-03 -1.382298e-03 -1.447308e-03
## ASV0170      2.618440e-04  2.737162e-04  2.861043e-04  2.990292e-04
## ASV2466     -1.113250e-03 -1.163351e-03 -1.215600e-03 -1.270080e-03
## ASV1709      8.554946e-04  8.932936e-04  9.326459e-04  9.736062e-04
## ASV6170     -8.071766e-04 -8.443922e-04 -8.832684e-04 -9.238742e-04
## ASV3673      9.251663e-04  9.679179e-04  1.012586e-03  1.059250e-03
## ASV1745      7.186196e-05  7.522966e-05  7.875022e-05  8.242996e-05
##                                                                    
## (Intercept) -5.987081e-05 -6.771975e-05 -7.654384e-05 -8.645478e-05
## ASV1236      7.540073e-04  7.857923e-04  8.187474e-04  8.529027e-04
## ASV0421     -1.350727e-03 -1.408335e-03 -1.468116e-03 -1.530130e-03
## ASV0691     -1.139244e-03 -1.185255e-03 -1.232791e-03 -1.281875e-03
## ASV0899      6.770706e-06  8.650441e-06  1.072373e-05  1.300422e-05
## ASV1004      1.536524e-03  1.602115e-03  1.670179e-03  1.740784e-03
## ASV1041     -1.040997e-03 -1.085438e-03 -1.131547e-03 -1.179367e-03
## ASV1058      1.429528e-03  1.490708e-03  1.554220e-03  1.620129e-03
## ASV12542     4.213182e-04  4.381091e-04  4.554361e-04  4.733060e-04
## ASV1294      1.679747e-03  1.752872e-03  1.828888e-03  1.907886e-03
## ASV13113     6.393736e-04  6.698871e-04  7.018572e-04  7.353531e-04
## ASV1318      1.450544e-03  1.512677e-03  1.577175e-03  1.644105e-03
## ASV2269     -4.330779e-04 -4.516593e-04 -4.709459e-04 -4.909566e-04
## ASV2542      9.819896e-04  1.027666e-03  1.075415e-03  1.125325e-03
## ASV2660     -8.241340e-04 -8.585486e-04 -8.941951e-04 -9.311009e-04
## ASV2737     -5.594821e-05 -5.917158e-05 -6.258238e-05 -6.619048e-05
## ASV2840      1.089140e-03  1.134048e-03  1.180509e-03  1.228552e-03
## ASV3053      5.551208e-05  5.759100e-05  5.972910e-05  6.192704e-05
## ASV3077      3.420017e-04  3.563676e-04  3.712617e-04  3.866980e-04
## ASV3134      1.279623e-03  1.340116e-03  1.403447e-03  1.469748e-03
## ASV3140      5.532602e-04  5.787205e-04  6.053031e-04  6.330525e-04
## ASV3579      2.486790e-04  2.619998e-04  2.760776e-04  2.909573e-04
## ASV6119     -4.328488e-04 -4.514111e-04 -4.706770e-04 -4.906655e-04
## ASV7557     -4.327266e-04 -4.512782e-04 -4.705325e-04 -4.905084e-04
## ASV8422      2.307704e-04  2.400564e-04  2.496521e-04  2.595635e-04
## ASV1086     -1.153056e-04 -1.199149e-04 -1.246769e-04 -1.295945e-04
## ASV1310      8.328419e-04  8.691823e-04  9.069609e-04  9.462219e-04
## ASV15750    -2.006987e-04 -2.089678e-04 -2.175170e-04 -2.263502e-04
## ASV16905    -4.326780e-04 -4.512253e-04 -4.704750e-04 -4.904459e-04
## ASV2033      8.637966e-04  9.043997e-04  9.468774e-04  9.913122e-04
## ASV2089      2.978795e-04  3.107455e-04  3.241054e-04  3.379727e-04
## ASV2127      1.187265e-03  1.238471e-03  1.291661e-03  1.346896e-03
## ASV2725      1.315889e-03  1.370667e-03  1.427394e-03  1.486115e-03
## ASV2804     -4.326583e-04 -4.512047e-04 -4.704536e-04 -4.904238e-04
## ASV3075      8.632903e-04  9.014312e-04  9.411500e-04  9.825051e-04
## ASV3327      8.372467e-04  8.761910e-04  9.169042e-04  9.594623e-04
## ASV3342      8.987598e-04  9.396146e-04  9.822389e-04  1.026702e-03
## ASV3532     -8.096458e-04 -8.463901e-04 -8.847255e-04 -9.247149e-04
## ASV3600      1.022326e-03  1.068456e-03  1.116563e-03  1.166725e-03
## ASV4013      8.403048e-04  8.768377e-04  9.148119e-04  9.542723e-04
## ASV4136      8.185507e-04  8.531136e-04  8.889560e-04  9.261116e-04
## ASV4195      4.324900e-04  4.510222e-04  4.702558e-04  4.902095e-04
## ASV4407     -4.323680e-04 -4.508895e-04 -4.701115e-04 -4.900527e-04
## ASV4717      1.301823e-05  1.283483e-05  1.258766e-05  1.227100e-05
## ASV6794      4.303758e-04  4.477878e-04  4.657885e-04  4.843898e-04
## ASV8324     -4.323246e-04 -4.508417e-04 -4.700588e-04 -4.899946e-04
## ASV8981     -9.861385e-05 -1.015497e-04 -1.044739e-04 -1.073739e-04
## ASV9859      3.725914e-04  3.915930e-04  4.116086e-04  4.326951e-04
## ASV0936     -6.839440e-04 -7.136645e-04 -7.445584e-04 -7.766623e-04
## ASV12683    -7.915855e-05 -8.317601e-05 -8.739496e-05 -9.182448e-05
## ASV1293      9.970840e-04  1.039497e-03  1.083500e-03  1.129135e-03
## ASV13055    -9.912783e-05 -1.028922e-04 -1.067515e-04 -1.107036e-04
## ASV17063    -4.321418e-04 -4.506451e-04 -4.698477e-04 -4.897682e-04
## ASV2228      4.320200e-04  4.505126e-04  4.697037e-04  4.896117e-04
## ASV2769     -6.386347e-05 -6.545419e-05 -6.700178e-05 -6.849574e-05
## ASV2803      1.951982e-04  2.028523e-04  2.107432e-04  2.188738e-04
## ASV2896      5.625998e-04  5.882239e-04  6.149830e-04  6.429259e-04
## ASV3062      1.955552e-04  2.060815e-04  2.172094e-04  2.289750e-04
## ASV3107      6.767144e-04  7.073539e-04  7.393179e-04  7.726588e-04
## ASV3265      1.294725e-03  1.349649e-03  1.406619e-03  1.465687e-03
## ASV3666     -3.346133e-05 -3.517530e-05 -3.698074e-05 -3.888286e-05
## ASV4497      3.081014e-04  3.212904e-04  3.349837e-04  3.491960e-04
## ASV6914     -1.576782e-04 -1.648574e-04 -1.723445e-04 -1.801509e-04
## ASV0576     -1.496076e-03 -1.557329e-03 -1.620685e-03 -1.686183e-03
## ASV0673      4.324673e-04  4.532899e-04  4.750981e-04  4.979351e-04
## ASV0772      4.746884e-04  4.957192e-04  5.176219e-04  5.404282e-04
## ASV0862     -3.524486e-04 -3.660235e-04 -3.799798e-04 -3.943159e-04
## ASV0898      4.195248e-04  4.399477e-04  4.613647e-04  4.838226e-04
## ASV0910      8.903759e-04  9.327224e-04  9.770652e-04  1.023495e-03
## ASV0964     -5.464428e-04 -5.691071e-04 -5.925685e-04 -6.168431e-04
## ASV10059     4.209211e-04  4.412955e-04  4.626671e-04  4.850849e-04
## ASV10263    -4.327108e-04 -4.512664e-04 -4.705261e-04 -4.905087e-04
## ASV1088      4.761762e-04  4.991316e-04  5.232077e-04  5.484603e-04
## ASV1101      7.625697e-04  7.959933e-04  8.307449e-04  8.668646e-04
## ASV1183      4.952870e-04  5.175612e-04  5.407760e-04  5.649660e-04
## ASV11956     1.728464e-04  1.792798e-04  1.858817e-04  1.926512e-04
## ASV12774    -7.324850e-05 -7.693869e-05 -8.081562e-05 -8.488836e-05
## ASV1321      2.285521e-04  2.410459e-04  2.542629e-04  2.682462e-04
## ASV13793    -4.325665e-04 -4.511094e-04 -4.703552e-04 -4.903229e-04
## ASV14482    -4.853269e-05 -5.118316e-05 -5.397621e-05 -5.691842e-05
## ASV15483     3.183978e-04  3.330600e-04  3.483775e-04  3.643775e-04
## ASV2062      1.945123e-03  2.031011e-03  2.120406e-03  2.213426e-03
## ASV2132      9.096671e-04  9.515666e-04  9.953343e-04  1.041048e-03
## ASV2413      1.235543e-03  1.288619e-03  1.343743e-03  1.400975e-03
## ASV2490      7.978191e-04  8.309809e-04  8.653197e-04  9.008615e-04
## ASV2594      4.573441e-04  4.778638e-04  4.992685e-04  5.215951e-04
## ASV2822     -4.327878e-04 -4.513518e-04 -4.706208e-04 -4.906139e-04
## ASV2863      7.481682e-04  7.798348e-04  8.126783e-04  8.467297e-04
## ASV2910      9.729971e-04  1.014006e-03  1.056524e-03  1.100591e-03
## ASV2980      3.532803e-04  3.681681e-04  3.835960e-04  3.995761e-04
## ASV3307      4.325849e-04  4.511312e-04  4.703810e-04  4.903534e-04
## ASV3474      7.287755e-04  7.636383e-04  8.001614e-04  8.384220e-04
## ASV3502      1.442470e-03  1.506612e-03  1.573417e-03  1.642981e-03
## ASV4236      7.022502e-04  7.314456e-04  7.616757e-04  7.929626e-04
## ASV4842     -2.397117e-04 -2.501961e-04 -2.610910e-04 -2.724081e-04
## ASV4894     -4.327435e-04 -4.513052e-04 -4.705718e-04 -4.905626e-04
## ASV5290      5.453698e-04  5.696264e-04  5.948849e-04  6.211799e-04
## ASV5501      1.016020e-04  1.061402e-04  1.108757e-04  1.158171e-04
## ASV5795      3.795311e-04  3.972768e-04  4.158354e-04  4.352424e-04
## ASV5987     -4.328051e-04 -4.513731e-04 -4.706469e-04 -4.906456e-04
## ASV6267     -4.326828e-04 -4.512402e-04 -4.705024e-04 -4.904885e-04
## ASV6862      8.098616e-04  8.429088e-04  8.770834e-04  9.124069e-04
## ASV7145      1.447001e-04  1.503869e-04  1.562582e-04  1.623179e-04
## ASV7673     -4.326437e-04 -4.511972e-04 -4.704552e-04 -4.904368e-04
## ASV7789      1.891179e-04  1.995562e-04  2.106124e-04  2.223248e-04
## ASV7809     -3.761056e-05 -3.807586e-05 -3.845307e-05 -3.872993e-05
## ASV8002     -4.325755e-04 -4.511250e-04 -4.703788e-04 -4.903561e-04
## ASV8205      2.588663e-04  2.705243e-04  2.826869e-04  2.953747e-04
## ASV9155     -3.236417e-04 -3.373564e-04 -3.515761e-04 -3.663129e-04
## ASV9221     -3.082556e-05 -3.077419e-05 -3.059059e-05 -3.025847e-05
## ASV9311     -4.324260e-04 -4.509635e-04 -4.702046e-04 -4.901684e-04
## ASV9557     -4.323039e-04 -4.508308e-04 -4.700603e-04 -4.900116e-04
## ASV9936     -4.321820e-04 -4.506981e-04 -4.699161e-04 -4.898548e-04
## ASV1445      1.040283e-03  1.087857e-03  1.137523e-03  1.189365e-03
## ASV4232      8.993955e-04  9.420349e-04  9.866930e-04  1.033465e-03
## ASV6479      2.745540e-05  3.088389e-05  3.465020e-05  3.878323e-05
## ASV0142     -2.161827e-03 -2.252658e-03 -2.346805e-03 -2.444349e-03
## ASV0378     -6.931264e-04 -7.210460e-04 -7.498629e-04 -7.795862e-04
## ASV1122      1.375838e-03  1.438773e-03  1.504469e-03  1.573037e-03
## ASV0123     -2.115630e-03 -2.204363e-03 -2.296321e-03 -2.391581e-03
## ASV2064      2.066249e-04  2.144094e-04  2.224002e-04  2.305955e-04
## ASV4459     -2.345337e-04 -2.443965e-04 -2.546173e-04 -2.652044e-04
## ASV0448      4.306181e-04  4.529057e-04  4.763901e-04  5.011364e-04
## ASV0397      1.017267e-03  1.063032e-03  1.110738e-03  1.160459e-03
## ASV0485      1.403525e-03  1.465344e-03  1.529686e-03  1.596638e-03
## ASV1566      1.189112e-03  1.242395e-03  1.297917e-03  1.355759e-03
## ASV1365      7.737608e-04  8.086731e-04  8.450746e-04  8.830215e-04
## ASV1065      1.581523e-03  1.652665e-03  1.726828e-03  1.804124e-03
## ASV0722     -2.593332e-05 -2.666373e-05 -2.739445e-05 -2.812382e-05
## ASV12660    -7.078927e-04 -7.373706e-04 -7.679056e-04 -7.995226e-04
## ASV0223     -2.546718e-05 -2.629081e-05 -2.711639e-05 -2.794047e-05
## ASV0229      7.209831e-04  7.544151e-04  7.893577e-04  8.258759e-04
## ASV0877     -2.460268e-04 -2.554319e-04 -2.650979e-04 -2.750244e-04
## ASV0983      1.421623e-03  1.483366e-03  1.547542e-03  1.614226e-03
## ASV0626     -4.225666e-04 -4.378024e-04 -4.533715e-04 -4.692626e-04
## ASV4146     -7.477699e-05 -7.780007e-05 -8.092469e-05 -8.415308e-05
## ASV4175     -8.878113e-04 -9.274965e-04 -9.688402e-04 -1.011902e-03
## ASV2082     -8.800480e-05 -9.369281e-05 -9.978559e-05 -1.063134e-04
## ASV2272      6.545443e-04  6.848217e-04  7.164648e-04  7.495322e-04
## ASV2245     -7.794629e-04 -8.147379e-04 -8.515243e-04 -8.898797e-04
## ASV0590     -5.099030e-04 -5.354871e-04 -5.623875e-04 -5.906726e-04
## ASV0217     -6.137083e-04 -6.339838e-04 -6.544999e-04 -6.752164e-04
## ASV0416      6.690337e-04  6.953593e-04  7.224862e-04  7.504198e-04
## ASV1056      8.990195e-04  9.420996e-04  9.872302e-04  1.034505e-03
## ASV7777     -7.682792e-04 -8.027908e-04 -8.387649e-04 -8.762566e-04
## ASV0455      1.671035e-04  1.753888e-04  1.840820e-04  1.932017e-04
## ASV0604      2.023501e-04  2.137872e-04  2.259044e-04  2.387422e-04
## ASV6100     -7.123065e-04 -7.445080e-04 -7.780931e-04 -8.131157e-04
## ASV11359    -7.867788e-04 -8.215674e-04 -8.577767e-04 -8.954547e-04
## ASV6604      5.782324e-04  6.052501e-04  6.335064e-04  6.630559e-04
## ASV5004     -4.607297e-04 -4.810444e-04 -5.021860e-04 -5.241829e-04
## ASV1483     -4.281964e-04 -4.472934e-04 -4.671859e-04 -4.879026e-04
## ASV9773     -9.098508e-04 -9.507839e-04 -9.934567e-04 -1.037935e-03
## ASV4059      1.079561e-04  1.143059e-04  1.210566e-04  1.282342e-04
## ASV1193      1.474840e-03  1.540721e-03  1.609357e-03  1.680848e-03
## ASV4610     -8.977740e-05 -9.115571e-05 -9.238081e-05 -9.343180e-05
## ASV0742     -4.938479e-04 -5.119023e-04 -5.303736e-04 -5.492500e-04
## ASV1502     -2.697545e-05 -2.945638e-05 -3.214971e-05 -3.507193e-05
## ASV0195     -1.860934e-04 -1.959853e-04 -2.064185e-04 -2.174221e-04
## ASV1213      4.380008e-04  4.555117e-04  4.735771e-04  4.922022e-04
## ASV1648     -6.706487e-04 -7.006449e-04 -7.319038e-04 -7.644725e-04
## ASV6984     -5.068428e-04 -5.298609e-04 -5.538794e-04 -5.789384e-04
## ASV0396     -2.988940e-04 -3.067517e-04 -3.144750e-04 -3.220225e-04
## ASV4297      7.268027e-04  7.571687e-04  7.886302e-04  8.212135e-04
## ASV2622      1.675440e-03  1.746920e-03  1.821108e-03  1.898083e-03
## ASV3512      3.003910e-04  3.163788e-04  3.332708e-04  3.511210e-04
## ASV2411      6.176723e-04  6.470601e-04  6.778343e-04  7.100584e-04
## ASV2291     -1.728273e-04 -1.821652e-04 -1.920396e-04 -2.024826e-04
## ASV0807      7.506007e-04  7.880149e-04  8.273251e-04  8.686265e-04
## ASV1292      3.782080e-04  3.943891e-04  4.111929e-04  4.286383e-04
## ASV1035      1.663915e-04  1.728163e-04  1.794363e-04  1.862542e-04
## ASV0070     -3.597016e-04 -3.722520e-04 -3.850125e-04 -3.979635e-04
## ASV0255      1.661102e-04  1.734199e-04  1.810165e-04  1.889073e-04
## ASV0057     -1.688686e-03 -1.757753e-03 -1.829159e-03 -1.902944e-03
## ASV0077     -2.160301e-04 -2.225827e-04 -2.291380e-04 -2.356732e-04
## ASV0625      1.707942e-03  1.779818e-03  1.854324e-03  1.931522e-03
## ASV2464      8.133176e-04  8.466822e-04  8.812054e-04  9.169119e-04
## ASV1315      1.595104e-03  1.670095e-03  1.748555e-03  1.830635e-03
## ASV2673      1.171493e-03  1.227351e-03  1.285868e-03  1.347167e-03
## ASV2161      4.857345e-04  5.091167e-04  5.336305e-04  5.593309e-04
## ASV0337     -7.317536e-04 -7.637708e-04 -7.970657e-04 -8.316788e-04
## ASV7680     -8.780336e-04 -9.177715e-04 -9.592179e-04 -1.002439e-03
## ASV0611      1.939664e-03  2.029625e-03  2.123658e-03  2.221942e-03
## ASV3118     -6.559650e-04 -6.861233e-04 -7.176169e-04 -7.505005e-04
## ASV1284      6.913891e-04  7.231282e-04  7.562726e-04  7.908801e-04
## ASV0889      5.097031e-04  5.319792e-04  5.551539e-04  5.792579e-04
## ASV4649     -5.409024e-04 -5.650827e-04 -5.902754e-04 -6.165172e-04
## ASV1108     -7.257416e-04 -7.606103e-04 -7.971564e-04 -8.354600e-04
## ASV0738     -2.547603e-05 -2.100744e-05 -1.586445e-05 -9.981799e-06
## ASV0473      1.087851e-04  1.138519e-04  1.191549e-04  1.247054e-04
## ASV0598     -7.378084e-04 -7.675414e-04 -7.982452e-04 -8.299329e-04
## ASV0429      1.234922e-03  1.288828e-03  1.344874e-03  1.403127e-03
## ASV1549      1.310489e-03  1.373323e-03  1.439171e-03  1.508175e-03
## ASV1203      9.400157e-04  9.815573e-04  1.024796e-03  1.069791e-03
## ASV4532      3.126239e-05  3.201290e-05  3.275155e-05  3.347595e-05
## ASV0274     -8.981897e-04 -9.347252e-04 -9.724876e-04 -1.011497e-03
## ASV0163     -1.276061e-03 -1.327474e-03 -1.380567e-03 -1.435362e-03
## ASV1298      5.186989e-04  5.396743e-04  5.613511e-04  5.837418e-04
## ASV9424     -1.173436e-03 -1.227206e-03 -1.283350e-03 -1.341965e-03
## ASV0412      1.759875e-03  1.837177e-03  1.917610e-03  2.001281e-03
## ASV0284      7.581777e-04  7.894460e-04  8.218061e-04  8.552806e-04
## ASV0620     -6.257820e-04 -6.559140e-04 -6.874915e-04 -7.205819e-04
## ASV0153     -1.275741e-03 -1.335455e-03 -1.397905e-03 -1.463211e-03
## ASV0498      1.947147e-04  2.075251e-04  2.212128e-04  2.358357e-04
## ASV0097      9.223524e-04  9.661999e-04  1.012125e-03  1.060227e-03
## ASV0104     -4.077604e-03 -4.258626e-03 -4.447127e-03 -4.643368e-03
## ASV1282      7.229665e-04  7.559782e-04  7.904289e-04  8.263750e-04
## ASV3883     -4.317135e-04 -4.522523e-04 -4.737540e-04 -4.962614e-04
## ASV0801      4.419459e-04  4.637692e-04  4.866779e-04  5.107251e-04
## ASV1611     -1.601506e-03 -1.674872e-03 -1.751474e-03 -1.831441e-03
## ASV0227     -6.161645e-04 -6.467700e-04 -6.789184e-04 -7.126867e-04
## ASV0833      6.601642e-04  6.927986e-04  7.270603e-04  7.630286e-04
## ASV0718      1.475621e-03  1.542136e-03  1.611492e-03  1.683794e-03
## ASV1139      4.900556e-04  5.085223e-04  5.274575e-04  5.468519e-04
## ASV0766     -3.873222e-04 -4.036623e-04 -4.206006e-04 -4.381519e-04
## ASV2091      1.894238e-03  1.973585e-03  2.055807e-03  2.140971e-03
## ASV1238     -8.345217e-05 -8.426942e-05 -8.486962e-05 -8.522419e-05
## ASV9193     -2.120754e-04 -2.240000e-04 -2.366316e-04 -2.500127e-04
## ASV0290     -1.881926e-04 -1.981984e-04 -2.087481e-04 -2.198701e-04
## ASV0231      1.546861e-03  1.615290e-03  1.686531e-03  1.760682e-03
## ASV0185      4.011375e-04  4.279306e-04  4.566319e-04  4.873787e-04
## ASV2330      4.352817e-04  4.537158e-04  4.728361e-04  4.926607e-04
## ASV3119     -5.626967e-04 -5.915388e-04 -6.219133e-04 -6.539036e-04
## ASV2368     -7.371287e-04 -7.720977e-04 -8.087186e-04 -8.470686e-04
## ASV0122     -5.325321e-04 -5.544308e-04 -5.770891e-04 -6.005223e-04
## ASV1044      1.032856e-03  1.083211e-03  1.136042e-03  1.191471e-03
## ASV0160     -1.296684e-03 -1.348647e-03 -1.402274e-03 -1.457582e-03
## ASV0326      8.992317e-04  9.397592e-04  9.820104e-04  1.026049e-03
## ASV1388      1.561647e-03  1.631093e-03  1.703418e-03  1.778727e-03
## ASV0792      1.740876e-03  1.816172e-03  1.894401e-03  1.975650e-03
## ASV0036     -1.146796e-03 -1.199889e-03 -1.255362e-03 -1.313313e-03
## ASV2125      1.824467e-03  1.905495e-03  1.989873e-03  2.077718e-03
## ASV1075      3.659080e-04  3.834432e-04  4.018196e-04  4.210772e-04
## ASV0390      3.843591e-04  4.045864e-04  4.259384e-04  4.484811e-04
## ASV3790     -1.490142e-03 -1.558094e-03 -1.629011e-03 -1.703013e-03
## ASV1535     -1.373276e-04 -1.447454e-04 -1.525913e-04 -1.608914e-04
## ASV0263      3.062217e-04  3.200702e-04  3.345124e-04  3.495709e-04
## ASV0675      2.497373e-03  2.614848e-03  2.737764e-03  2.866364e-03
## ASV3348      2.520371e-04  2.647889e-04  2.782095e-04  2.923352e-04
## ASV0058     -2.288525e-03 -2.389216e-03 -2.493978e-03 -2.602946e-03
## ASV4142      5.700529e-04  5.947842e-04  6.204767e-04  6.471581e-04
## ASV0059     -1.967687e-03 -2.053820e-03 -2.143394e-03 -2.236520e-03
## ASV0013     -4.138285e-03 -4.321980e-03 -4.513266e-03 -4.712412e-03
## ASV0033     -1.252196e-03 -1.310448e-03 -1.371338e-03 -1.434978e-03
## ASV4354     -5.153520e-04 -5.372714e-04 -5.600263e-04 -5.836421e-04
## ASV0022     -1.317624e-03 -1.378648e-03 -1.442410e-03 -1.509023e-03
## ASV0134     -3.446466e-04 -3.618171e-04 -3.798559e-04 -3.988066e-04
## ASV0415     -2.218540e-04 -2.284563e-04 -2.350621e-04 -2.416508e-04
## ASV10103    -9.130432e-04 -9.546982e-04 -9.981713e-04 -1.043534e-03
## ASV1613      1.427847e-03  1.489443e-03  1.553421e-03  1.619851e-03
## ASV0135     -1.664754e-05 -1.291689e-05 -8.631468e-06 -3.736486e-06
## ASV0469     -1.775292e-03 -1.851539e-03 -1.930723e-03 -2.012929e-03
## ASV0471      1.162354e-03  1.214778e-03  1.269437e-03  1.326416e-03
## ASV0451     -3.444477e-04 -3.619190e-04 -3.803040e-04 -3.996511e-04
## ASV0747      4.819550e-04  5.058266e-04  5.308955e-04  5.572211e-04
## ASV1314     -7.304574e-04 -7.662792e-04 -8.038931e-04 -8.433910e-04
## ASV0425     -1.981438e-03 -2.063958e-03 -2.149415e-03 -2.237875e-03
## ASV0559     -1.127369e-03 -1.174501e-03 -1.223354e-03 -1.273973e-03
## ASV0148     -1.213414e-03 -1.263220e-03 -1.314725e-03 -1.367957e-03
## ASV0129     -5.662574e-04 -5.867090e-04 -6.075894e-04 -6.288777e-04
## ASV1072      5.830123e-04  6.064678e-04  6.306764e-04  6.556457e-04
## ASV2390      4.157096e-04  4.324028e-04  4.496250e-04  4.673803e-04
## ASV0548      1.346161e-03  1.407417e-03  1.471336e-03  1.538023e-03
## ASV0168     -1.969209e-03 -2.054636e-03 -2.143428e-03 -2.235690e-03
## ASV0066     -1.470908e-03 -1.535445e-03 -1.602577e-03 -1.672389e-03
## ASV0468     -5.499997e-04 -5.746543e-04 -6.003515e-04 -6.271307e-04
## ASV0172     -2.484590e-04 -2.549888e-04 -2.613947e-04 -2.676390e-04
## ASV0236     -6.851985e-04 -7.094977e-04 -7.342679e-04 -7.594809e-04
## ASV0250      1.384530e-04  1.518503e-04  1.664457e-04  1.823376e-04
## ASV0338     -5.704346e-05 -5.596636e-05 -5.454988e-05 -5.275988e-05
## ASV0450     -5.932878e-06 -6.119039e-06 -6.306590e-06 -6.495249e-06
## ASV0377      1.631133e-03  1.703881e-03  1.779665e-03  1.858594e-03
## ASV1022      4.594480e-04  4.803748e-04  5.022197e-04  5.250205e-04
## ASV6174     -1.075775e-04 -1.121033e-04 -1.168026e-04 -1.216816e-04
## ASV0786      1.680149e-04  1.744962e-04  1.811656e-04  1.880238e-04
## ASV0053     -1.969791e-03 -2.058157e-03 -2.150254e-03 -2.246220e-03
## ASV0697     -5.341222e-04 -5.555077e-04 -5.775798e-04 -6.003469e-04
## ASV0785      1.463453e-03  1.528889e-03  1.597070e-03  1.668096e-03
## ASV1967     -9.262406e-04 -9.648720e-04 -1.004902e-03 -1.046366e-03
## ASV0385     -4.190751e-04 -4.355049e-04 -4.524300e-04 -4.698532e-04
## ASV0295      5.678788e-05  6.320490e-05  7.023763e-05  7.793888e-05
## ASV0072     -1.510138e-03 -1.573338e-03 -1.638804e-03 -1.706587e-03
## ASV0157     -6.010735e-04 -6.241973e-04 -6.479488e-04 -6.723198e-04
## ASV0501      7.532867e-04  7.897508e-04  8.279902e-04  8.680906e-04
## ASV10729    -1.211494e-03 -1.266652e-03 -1.324206e-03 -1.384251e-03
## ASV1470      5.526428e-04  5.761204e-04  6.004731e-04  6.257236e-04
## ASV0050     -3.877792e-03 -4.047726e-03 -4.224485e-03 -4.408292e-03
## ASV0411     -7.688472e-05 -7.851507e-05 -8.005410e-05 -8.148484e-05
## ASV0549      7.787474e-04  8.160776e-04  8.551995e-04  8.961984e-04
## ASV0184      4.580447e-04  4.785961e-04  5.000270e-04  5.223725e-04
## ASV0705      5.674959e-04  5.939194e-04  6.215317e-04  6.503814e-04
## ASV1715      1.401902e-03  1.465255e-03  1.531327e-03  1.600223e-03
## ASV0603      1.746957e-04  1.832228e-04  1.921789e-04  2.015868e-04
## ASV0826      4.458144e-04  4.642394e-04  4.833073e-04  5.030309e-04
## ASV0034     -1.730756e-03 -1.804934e-03 -1.881933e-03 -1.961830e-03
## ASV0838      3.667831e-04  3.825679e-04  3.989496e-04  4.159429e-04
## ASV0614     -9.899931e-04 -1.032957e-03 -1.077612e-03 -1.124009e-03
## ASV0014     -3.764780e-03 -3.930217e-03 -4.102343e-03 -4.281380e-03
## ASV0585     -2.441807e-04 -2.554423e-04 -2.672034e-04 -2.794841e-04
## ASV0016     -3.851501e-03 -4.020954e-03 -4.197275e-03 -4.380698e-03
## ASV5394     -9.951465e-04 -1.040243e-03 -1.087278e-03 -1.136326e-03
## ASV0666      8.288552e-04  8.651897e-04  9.029828e-04  9.422819e-04
## ASV2085      2.703799e-04  2.782395e-04  2.860737e-04  2.938539e-04
## ASV0003     -3.510861e-03 -3.664467e-03 -3.824225e-03 -3.990336e-03
## ASV0346     -6.393074e-06 -2.359213e-06  2.208745e-06  7.359321e-06
## ASV0267     -5.237548e-04 -5.442654e-04 -5.653766e-04 -5.870881e-04
## ASV0353      8.208604e-04  8.620520e-04  9.053648e-04  9.509095e-04
## ASV2419      9.846019e-04  1.027222e-03  1.071514e-03  1.117530e-03
## ASV0447      5.436635e-04  5.726920e-04  6.033358e-04  6.356854e-04
## ASV0654      1.581983e-03  1.654529e-03  1.730262e-03  1.809307e-03
## ASV0151      2.865926e-04  3.027124e-04  3.198108e-04  3.379507e-04
## ASV0065     -1.423186e-03 -1.485836e-03 -1.551022e-03 -1.618826e-03
## ASV0527      1.032897e-03  1.078613e-03  1.126206e-03  1.175741e-03
## ASV4055     -4.095408e-04 -4.293973e-04 -4.502302e-04 -4.720886e-04
## ASV0166     -1.153110e-03 -1.201589e-03 -1.251840e-03 -1.303906e-03
## ASV0417     -9.914565e-04 -1.034437e-03 -1.079110e-03 -1.125529e-03
## ASV0078     -7.780773e-04 -8.104319e-04 -8.439191e-04 -8.785596e-04
## ASV0322     -9.470102e-04 -9.864570e-04 -1.027299e-03 -1.069564e-03
## ASV0156     -1.250866e-03 -1.304707e-03 -1.360636e-03 -1.418715e-03
## ASV0648     -1.179840e-03 -1.234242e-03 -1.291069e-03 -1.350421e-03
## ASV0407      1.070190e-04  1.131025e-04  1.195573e-04  1.264068e-04
## ASV2030     -2.245015e-04 -2.331029e-04 -2.419641e-04 -2.510892e-04
## ASV0300      7.271665e-04  7.631805e-04  8.010059e-04  8.407334e-04
## ASV1150     -6.901453e-05 -7.074175e-05 -7.241894e-05 -7.403350e-05
## ASV0958      7.595595e-04  7.973393e-04  8.370531e-04  8.788033e-04
## ASV0216     -1.168482e-03 -1.217316e-03 -1.267924e-03 -1.320350e-03
## ASV0446      1.763811e-03  1.847533e-03  1.935176e-03  2.026917e-03
## ASV0367     -5.753219e-04 -6.006678e-04 -6.270471e-04 -6.544954e-04
## ASV0200     -1.084273e-03 -1.132940e-03 -1.183673e-03 -1.236551e-03
## ASV0334     -4.830843e-04 -4.993547e-04 -5.158609e-04 -5.325766e-04
## ASV1311      7.494247e-04  7.819002e-04  8.156458e-04  8.506997e-04
## ASV0458      8.168727e-04  8.529042e-04  8.904163e-04  9.294621e-04
## ASV1371      2.797778e-05  2.943985e-05  3.098172e-05  3.260779e-05
## ASV0418      1.008667e-03  1.053911e-03  1.101074e-03  1.150229e-03
## ASV0004      1.190770e-03  1.243632e-03  1.298678e-03  1.355987e-03
## ASV1943      8.522374e-04  8.889447e-04  9.270892e-04  9.667168e-04
## ASV1495     -2.564546e-04 -2.709098e-04 -2.862364e-04 -3.024892e-04
## ASV0901     -1.399432e-03 -1.464703e-03 -1.532957e-03 -1.604325e-03
## ASV0628      7.719562e-04  8.046774e-04  8.386071e-04  8.737744e-04
## ASV0400      3.099014e-04  3.230678e-04  3.367210e-04  3.508727e-04
## ASV0116     -1.096430e-03 -1.148826e-03 -1.203719e-03 -1.261225e-03
## ASV0788      8.690466e-04  9.082031e-04  9.490290e-04  9.915874e-04
## ASV0117      5.938630e-04  6.230904e-04  6.537833e-04  6.860162e-04
## ASV3137      1.478650e-04  1.541726e-04  1.607198e-04  1.675134e-04
## ASV0001      1.377710e-03  1.435252e-03  1.494859e-03  1.556576e-03
## ASV1651      9.195213e-04  9.580504e-04  9.979843e-04  1.039358e-03
## ASV1692      1.065832e-03  1.116593e-03  1.169757e-03  1.225433e-03
## ASV0660      5.430581e-04  5.641731e-04  5.858853e-04  6.081905e-04
## ASV0508      5.630251e-05  5.778670e-05  5.925479e-05  6.070111e-05
## ASV1660     -4.474398e-04 -4.693307e-04 -4.922944e-04 -5.163816e-04
## ASV0233      2.511333e-04  2.636631e-04  2.768402e-04  2.906996e-04
## ASV1343     -1.043253e-03 -1.090943e-03 -1.140729e-03 -1.192696e-03
## ASV0209      9.072042e-04  9.446326e-04  9.833695e-04  1.023442e-03
## ASV0193     -1.202066e-03 -1.253222e-03 -1.306308e-03 -1.361377e-03
## ASV0357     -3.187708e-05 -3.036009e-05 -2.851047e-05 -2.629170e-05
## ASV0198      2.704366e-04  2.829203e-04  2.959649e-04  3.095948e-04
## ASV0007      1.305985e-03  1.360532e-03  1.417036e-03  1.475541e-03
## ASV1772     -1.346487e-04 -1.402846e-04 -1.461145e-04 -1.521404e-04
## ASV0009      1.228466e-03  1.279524e-03  1.332390e-03  1.387105e-03
## ASV0006      4.581694e-04  4.745998e-04  4.913704e-04  5.084650e-04
## ASV0011     -1.467490e-03 -1.535215e-03 -1.605969e-03 -1.679876e-03
## ASV0015      1.002821e-03  1.047441e-03  1.093911e-03  1.142295e-03
## ASV0017      1.059018e-03  1.105963e-03  1.154840e-03  1.205718e-03
## ASV0235     -8.544348e-04 -8.936346e-04 -9.345589e-04 -9.772767e-04
## ASV0382      2.056361e-04  2.185823e-04  2.323778e-04  2.470764e-04
## ASV2357      1.290093e-03  1.348773e-03  1.410010e-03  1.473906e-03
## ASV0567     -9.096826e-04 -9.492879e-04 -9.904803e-04 -1.033314e-03
## ASV0165      1.012867e-03  1.058059e-03  1.105141e-03  1.154180e-03
## ASV0005      2.005602e-03  2.092548e-03  2.182895e-03  2.276744e-03
## ASV0384     -6.059728e-05 -6.070072e-05 -6.056776e-05 -6.016762e-05
## ASV0002      4.654712e-04  4.882786e-04  5.122233e-04  5.373629e-04
## ASV3017      1.156581e-03  1.205847e-03  1.256970e-03  1.310000e-03
## ASV0091      4.737310e-04  4.959958e-04  5.192875e-04  5.436511e-04
## ASV0186     -1.243367e-03 -1.299880e-03 -1.358837e-03 -1.420331e-03
## ASV0370      1.343278e-04  1.409832e-04  1.479761e-04  1.553242e-04
## ASV0018      2.096049e-03  2.187427e-03  2.282426e-03  2.381161e-03
## ASV1377      1.823704e-03  1.902844e-03  1.985102e-03  2.070573e-03
## ASV0019      2.099548e-03  2.191138e-03  2.286364e-03  2.385340e-03
## ASV0023      9.056803e-05  9.066227e-05  9.042195e-05  8.980726e-05
## ASV2194      7.170628e-04  7.507450e-04  7.859896e-04  8.228671e-04
## ASV1155     -5.076276e-05 -5.102349e-05 -5.111223e-05 -5.100682e-05
## ASV0510     -7.155261e-04 -7.428703e-04 -7.709665e-04 -7.998107e-04
## ASV2371     -7.247506e-04 -7.543106e-04 -7.848856e-04 -8.164965e-04
## ASV0024     -1.208472e-05 -1.660453e-05 -2.165456e-05 -2.728194e-05
## ASV2452      9.587285e-04  9.985280e-04  1.039721e-03  1.082335e-03
## ASV2332      1.052372e-04  1.134764e-04  1.223455e-04  1.318885e-04
## ASV2591      1.003072e-04  1.082697e-04  1.168399e-04  1.260597e-04
## ASV0521      1.414059e-03  1.480576e-03  1.550176e-03  1.622996e-03
## ASV5542      4.501863e-04  4.720042e-04  4.948667e-04  5.188211e-04
## ASV0336     -6.363302e-04 -6.644346e-04 -6.936899e-04 -7.241361e-04
## ASV10102     9.688192e-04  1.013448e-03  1.060054e-03  1.108719e-03
## ASV16823    -6.948448e-04 -7.227269e-04 -7.515312e-04 -7.812743e-04
## ASV3104      6.946646e-04  7.225322e-04  7.513210e-04  7.810473e-04
## ASV0781      3.521767e-04  3.673526e-04  3.831123e-04  3.994725e-04
## ASV10899     3.993036e-04  4.206220e-04  4.431255e-04  4.668807e-04
## ASV11222    -6.945657e-04 -7.224268e-04 -7.512090e-04 -7.809284e-04
## ASV11327    -6.943857e-04 -7.222323e-04 -7.509989e-04 -7.807017e-04
## ASV12458    -6.942058e-04 -7.220379e-04 -7.507889e-04 -7.804750e-04
## ASV1636     -5.638939e-04 -5.861761e-04 -6.091578e-04 -6.328475e-04
## ASV1890     -7.028725e-04 -7.318790e-04 -7.619250e-04 -7.930376e-04
## ASV2898      1.570563e-03  1.638376e-03  1.708823e-03  1.781985e-03
## ASV8328     -6.101852e-05 -5.961807e-05 -5.781883e-05 -5.557982e-05
## ASV0709     -1.290385e-03 -1.346464e-03 -1.404745e-03 -1.465297e-03
## ASV0856      2.324238e-04  2.443037e-04  2.568064e-04  2.699646e-04
## ASV0909     -4.777191e-04 -4.939274e-04 -5.103786e-04 -5.270467e-04
## ASV0937     -1.036104e-03 -1.083403e-03 -1.132793e-03 -1.184365e-03
## ASV11390    -6.938360e-04 -7.216393e-04 -7.503596e-04 -7.800128e-04
## ASV11966     4.173884e-04  4.383926e-04  4.604686e-04  4.836699e-04
## ASV12990     2.077244e-04  2.172169e-04  2.271119e-04  2.374231e-04
## ASV14797     7.402853e-04  7.712689e-04  8.033679e-04  8.366081e-04
## ASV14904    -6.938095e-04 -7.216123e-04 -7.503321e-04 -7.799852e-04
## ASV15304     2.445865e-04  2.582458e-04  2.726972e-04  2.879858e-04
## ASV16696    -6.936799e-04 -7.214735e-04 -7.501837e-04 -7.798266e-04
## ASV1690      4.351968e-04  4.576380e-04  4.812523e-04  5.060985e-04
## ASV2029      2.035472e-03  2.124736e-03  2.217598e-03  2.314179e-03
## ASV2834      1.111747e-03  1.161982e-03  1.214379e-03  1.269021e-03
## ASV4003      3.790182e-04  4.000014e-04  4.222051e-04  4.457013e-04
## ASV4064      7.951700e-04  8.321003e-04  8.706867e-04  9.109970e-04
## ASV4294      3.144908e-04  3.316151e-04  3.497179e-04  3.688559e-04
## ASV4609     -1.626855e-05 -1.613345e-05 -1.592839e-05 -1.564644e-05
## ASV6283     -6.937368e-04 -7.215408e-04 -7.502629e-04 -7.799196e-04
## ASV6491     -6.935571e-04 -7.213466e-04 -7.500533e-04 -7.796933e-04
## ASV7453      3.445867e-04  3.631566e-04  3.827650e-04  4.034700e-04
## ASV7959      1.073423e-04  1.152128e-04  1.236617e-04  1.327288e-04
## ASV8219      6.934708e-04  7.212562e-04  7.499587e-04  7.795948e-04
## ASV8547     -6.932912e-04 -7.210622e-04 -7.497492e-04 -7.793687e-04
## ASV9319      5.254319e-04  5.502484e-04  5.762145e-04  6.033808e-04
## ASV9382     -6.931980e-04 -7.209626e-04 -7.496430e-04 -7.792555e-04
## ASV11516    -6.930186e-04 -7.207687e-04 -7.494336e-04 -7.790296e-04
## ASV14377    -6.928393e-04 -7.205750e-04 -7.492244e-04 -7.788038e-04
## ASV1867      1.116508e-03  1.167971e-03  1.221719e-03  1.277847e-03
## ASV1895     -2.318634e-04 -2.408733e-04 -2.501606e-04 -2.597293e-04
## ASV3168      4.494101e-04  4.682679e-04  4.877903e-04  5.079890e-04
## ASV4449      8.860830e-04  9.231485e-04  9.615805e-04  1.001417e-03
## ASV6596      5.870338e-04  6.168122e-04  6.481460e-04  6.811178e-04
## ASV7492     -2.175565e-04 -2.235123e-04 -2.294171e-04 -2.352468e-04
## ASV9854     -3.470896e-04 -3.604100e-04 -3.741261e-04 -3.882417e-04
## ASV6296      6.925021e-04  7.202134e-04  7.488371e-04  7.783893e-04
## ASV4201      3.168960e-04  3.356704e-04  3.556155e-04  3.768044e-04
## ASV0552      1.874093e-03  1.960918e-03  2.051644e-03  2.146434e-03
## ASV3671     -1.095605e-04 -1.118184e-04 -1.139717e-04 -1.160034e-04
## ASV3529     -1.058182e-04 -1.070181e-04 -1.079962e-04 -1.087259e-04
## ASV1060      4.765999e-04  4.990737e-04  5.226035e-04  5.472394e-04
## ASV0239     -9.754404e-04 -1.014769e-03 -1.055384e-03 -1.097302e-03
## ASV5711     -9.120595e-04 -9.500791e-04 -9.894855e-04 -1.030316e-03
## ASV4152     -1.239033e-03 -1.292860e-03 -1.348830e-03 -1.407014e-03
## ASV1461      1.066733e-03  1.110373e-03  1.155495e-03  1.202126e-03
## ASV2877      9.033102e-04  9.425005e-04  9.832202e-04  1.025515e-03
## ASV0012      7.265216e-04  7.614397e-04  7.980370e-04  8.363932e-04
## ASV9823      2.270795e-04  2.356911e-04  2.445262e-04  2.535810e-04
## ASV0008      7.856237e-04  8.228834e-04  8.618972e-04  9.027459e-04
## ASV7832     -7.530615e-04 -7.852404e-04 -8.186658e-04 -8.533775e-04
## ASV1915      8.581768e-05  9.110708e-05  9.672366e-05  1.026856e-04
## ASV0055      5.321451e-04  5.556498e-04  5.801105e-04  6.055590e-04
## ASV0032      1.254990e-03  1.308390e-03  1.363803e-03  1.421284e-03
## ASV2977     -1.042382e-03 -1.087586e-03 -1.134581e-03 -1.183426e-03
## ASV0466      1.029402e-03  1.072173e-03  1.116468e-03  1.162322e-03
## ASV3866      1.156960e-03  1.209993e-03  1.265365e-03  1.323172e-03
## ASV0040      1.558013e-03  1.630753e-03  1.706815e-03  1.786343e-03
## ASV0496     -1.319708e-04 -1.412398e-04 -1.511872e-04 -1.618614e-04
## ASV0052      1.815414e-03  1.894794e-03  1.977343e-03  2.063163e-03
## ASV3828     -1.104953e-03 -1.152681e-03 -1.202299e-03 -1.253872e-03
## ASV1930      7.088554e-04  7.404971e-04  7.734420e-04  8.077334e-04
## ASV2126      1.140259e-03  1.190524e-03  1.242828e-03  1.297241e-03
## ASV0793      7.461361e-04  7.831231e-04  8.219702e-04  8.627701e-04
## ASV0299     -4.295298e-04 -4.453919e-04 -4.616544e-04 -4.783134e-04
## ASV0208      1.118991e-03  1.172210e-03  1.227947e-03  1.286319e-03
## ASV0511     -5.164108e-04 -5.349483e-04 -5.538717e-04 -5.731636e-04
## ASV1123     -7.165020e-04 -7.450449e-04 -7.744950e-04 -8.048632e-04
## ASV0099     -4.076168e-04 -4.246373e-04 -4.422443e-04 -4.604453e-04
## ASV0752     -1.115026e-04 -1.179900e-04 -1.248634e-04 -1.321449e-04
## ASV0883      2.661308e-05  2.876988e-05  3.109398e-05  3.359708e-05
## ASV0683      9.956908e-04  1.042711e-03  1.091917e-03  1.143406e-03
## ASV4117     -1.115414e-03 -1.163784e-03 -1.214084e-03 -1.266377e-03
## ASV2172      4.295449e-04  4.489414e-04  4.691654e-04  4.902483e-04
## ASV0330     -7.819625e-04 -8.174109e-04 -8.543833e-04 -8.929380e-04
## ASV0728      7.682574e-04  8.046986e-04  8.428322e-04  8.827316e-04
## ASV0499      1.503478e-03  1.574685e-03  1.649239e-03  1.727294e-03
## ASV0120     -1.601457e-03 -1.672605e-03 -1.746680e-03 -1.823785e-03
## ASV1446      9.399725e-05  9.562274e-05  9.709938e-05  9.840412e-05
## ASV17171    -1.065089e-03 -1.111665e-03 -1.160134e-03 -1.210562e-03
## ASV0533      3.259949e-04  3.418787e-04  3.585464e-04  3.760371e-04
## ASV2495     -4.539472e-04 -4.754518e-04 -4.979879e-04 -5.216068e-04
## ASV5582      3.484419e-04  3.616932e-04  3.753019e-04  3.892652e-04
## ASV1488      3.658242e-04  3.832961e-04  4.015920e-04  4.207486e-04
## ASV0682      1.045653e-03  1.095075e-03  1.146808e-03  1.200957e-03
## ASV0068     -9.925160e-05 -1.062454e-04 -1.137444e-04 -1.217835e-04
## ASV1987     -5.945166e-04 -6.243567e-04 -6.557244e-04 -6.886982e-04
## ASV0035      1.242860e-04  1.252046e-04  1.257363e-04  1.258280e-04
## ASV7192     -6.903612e-04 -7.186492e-04 -7.479146e-04 -7.781769e-04
## ASV0873      7.386296e-05  7.505312e-05  7.613162e-05  7.708351e-05
## ASV4749     -2.840851e-07 -4.511638e-06 -9.285129e-06 -1.465556e-05
## ASV2174      6.463326e-04  6.721059e-04  6.987065e-04  7.261458e-04
## ASV1476     -6.077635e-04 -6.354659e-04 -6.643984e-04 -6.946144e-04
## ASV0740     -1.515328e-03 -1.586493e-03 -1.660944e-03 -1.738824e-03
## ASV0170      3.125125e-04  3.265764e-04  3.412441e-04  3.565395e-04
## ASV2466     -1.326879e-03 -1.386088e-03 -1.447801e-03 -1.512113e-03
## ASV1709      1.016231e-03  1.060577e-03  1.106703e-03  1.154669e-03
## ASV6170     -9.662815e-04 -1.010564e-03 -1.056799e-03 -1.105066e-03
## ASV3673      1.107995e-03  1.158906e-03  1.212074e-03  1.267591e-03
## ASV1745      8.627538e-05  9.029316e-05  9.449016e-05  9.887340e-05
##                                                                    
## (Intercept) -9.757550e-05 -1.100410e-04 -1.239993e-04 -1.396124e-04
## ASV1236      8.882876e-04  9.249316e-04  9.628637e-04  1.002113e-03
## ASV0421     -1.594436e-03 -1.661091e-03 -1.730154e-03 -1.801683e-03
## ASV0691     -1.332531e-03 -1.384782e-03 -1.438648e-03 -1.494147e-03
## ASV0899      1.550607e-05  1.824385e-05  2.123255e-05  2.448748e-05
## ASV1004      1.813996e-03  1.889881e-03  1.968503e-03  2.049926e-03
## ASV1041     -1.228940e-03 -1.280307e-03 -1.333508e-03 -1.388584e-03
## ASV1058      1.688502e-03  1.759405e-03  1.832905e-03  1.909067e-03
## ASV12542     4.917250e-04  5.106986e-04  5.302315e-04  5.503277e-04
## ASV1294      1.989957e-03  2.075194e-03  2.163690e-03  2.255539e-03
## ASV13113     7.704473e-04  8.072154e-04  8.457368e-04  8.860942e-04
## ASV1318      1.713532e-03  1.785523e-03  1.860143e-03  1.937457e-03
## ASV2269     -5.117099e-04 -5.332245e-04 -5.555187e-04 -5.786104e-04
## ASV2542      1.177490e-03  1.232004e-03  1.288969e-03  1.348487e-03
## ASV2660     -9.692931e-04 -1.008798e-03 -1.049640e-03 -1.091844e-03
## ASV2737     -7.000611e-05 -7.403980e-05 -7.830240e-05 -8.280500e-05
## ASV2840      1.278204e-03  1.329492e-03  1.382439e-03  1.437068e-03
## ASV3053      6.418549e-05  6.650513e-05  6.888667e-05  7.133086e-05
## ASV3077      4.026904e-04  4.192528e-04  4.363990e-04  4.541428e-04
## ASV3134      1.539155e-03  1.611811e-03  1.687866e-03  1.767475e-03
## ASV3140      6.620146e-04  6.922364e-04  7.237663e-04  7.566541e-04
## ASV3579      3.066865e-04  3.233157e-04  3.408979e-04  3.594894e-04
## ASV6119     -5.113951e-04 -5.328842e-04 -5.551512e-04 -5.782138e-04
## ASV7557     -5.112245e-04 -5.326990e-04 -5.549502e-04 -5.779957e-04
## ASV8422      2.697963e-04  2.803561e-04  2.912482e-04  3.024782e-04
## ASV1086     -1.346708e-04 -1.399086e-04 -1.453110e-04 -1.508809e-04
## ASV1310      9.870100e-04  1.029370e-03  1.073346e-03  1.118984e-03
## ASV15750    -2.354712e-04 -2.448831e-04 -2.545885e-04 -2.645894e-04
## ASV16905    -5.111565e-04 -5.326252e-04 -5.548702e-04 -5.779090e-04
## ASV2033      1.037790e-03  1.086399e-03  1.137233e-03  1.190385e-03
## ASV2089      3.523607e-04  3.672828e-04  3.827520e-04  3.987812e-04
## ASV2127      1.404234e-03  1.463734e-03  1.525458e-03  1.589465e-03
## ASV2725      1.546871e-03  1.609701e-03  1.674646e-03  1.741743e-03
## ASV2804     -5.111338e-04 -5.326020e-04 -5.548467e-04 -5.778855e-04
## ASV3075      1.025557e-03  1.070366e-03  1.116999e-03  1.165519e-03
## ASV3327      1.003945e-03  1.050434e-03  1.099014e-03  1.149775e-03
## ASV3342      1.073075e-03  1.121431e-03  1.171846e-03  1.224397e-03
## ASV3532     -9.664233e-04 -1.009918e-03 -1.055268e-03 -1.102544e-03
## ASV3600      1.219019e-03  1.273526e-03  1.330331e-03  1.389519e-03
## ASV4013      9.952643e-04  1.037834e-03  1.082027e-03  1.127889e-03
## ASV4136      9.646140e-04  1.004496e-03  1.045792e-03  1.088534e-03
## ASV4195      5.109018e-04  5.323510e-04  5.545752e-04  5.775921e-04
## ASV4407     -5.107315e-04 -5.321661e-04 -5.543745e-04 -5.773744e-04
## ASV4717      1.187888e-05  1.140509e-05  1.084316e-05  1.018643e-05
## ASV6794      5.036035e-04  5.234411e-04  5.439142e-04  5.650338e-04
## ASV8324     -5.106675e-04 -5.320957e-04 -5.542971e-04 -5.772892e-04
## ASV8981     -1.102360e-04 -1.130448e-04 -1.157836e-04 -1.184340e-04
## ASV9859      4.549128e-04  4.783254e-04  5.030002e-04  5.290083e-04
## ASV0936     -8.100138e-04 -8.446504e-04 -8.806101e-04 -9.179313e-04
## ASV12683    -9.647389e-05 -1.013527e-04 -1.064707e-04 -1.118379e-04
## ASV1293      1.176446e-03  1.225475e-03  1.276262e-03  1.328850e-03
## ASV13055    -1.147457e-04 -1.188742e-04 -1.230853e-04 -1.273741e-04
## ASV17063    -5.104250e-04 -5.318362e-04 -5.540199e-04 -5.769936e-04
## ASV2228      5.102550e-04  5.316517e-04  5.538196e-04  5.767763e-04
## ASV2769     -6.992463e-05 -7.127605e-05 -7.253662e-05 -7.369191e-05
## ASV2803      2.272466e-04  2.358638e-04  2.447272e-04  2.538384e-04
## ASV2896      6.721040e-04  7.025708e-04  7.343825e-04  7.675977e-04
## ASV3062      2.414162e-04  2.545731e-04  2.684882e-04  2.832063e-04
## ASV3107      8.074307e-04  8.436896e-04  8.814932e-04  9.209011e-04
## ASV3265      1.526907e-03  1.590329e-03  1.656006e-03  1.723988e-03
## ASV3666     -4.088721e-05 -4.299969e-05 -4.522657e-05 -4.757454e-05
## ASV4497      3.639416e-04  3.792353e-04  3.950915e-04  4.115249e-04
## ASV6914     -1.882883e-04 -1.967686e-04 -2.056038e-04 -2.148063e-04
## ASV0576     -1.753864e-03 -1.823766e-03 -1.895924e-03 -1.970373e-03
## ASV0673      5.218452e-04  5.468741e-04  5.730687e-04  6.004774e-04
## ASV0772      5.641709e-04  5.888834e-04  6.146001e-04  6.413565e-04
## ASV0862     -4.090289e-04 -4.241146e-04 -4.395676e-04 -4.553806e-04
## ASV0898      5.073701e-04  5.320579e-04  5.579385e-04  5.850666e-04
## ASV0910      1.072108e-03  1.123001e-03  1.176278e-03  1.232045e-03
## ASV0964     -6.419465e-04 -6.678936e-04 -6.946983e-04 -7.223739e-04
## ASV10059     5.086004e-04  5.332677e-04  5.591433e-04  5.862864e-04
## ASV10263    -5.112333e-04 -5.327184e-04 -5.549825e-04 -5.780439e-04
## ASV1088      5.749483e-04  6.027331e-04  6.318795e-04  6.624553e-04
## ASV1101      9.043928e-04  9.433694e-04  9.838344e-04  1.025827e-03
## ASV1183      5.901664e-04  6.164132e-04  6.437435e-04  6.721948e-04
## ASV11956     1.995870e-04  2.066874e-04  2.139502e-04  2.213728e-04
## ASV12774    -8.916638e-05 -9.365951e-05 -9.837798e-05 -1.033324e-04
## ASV1321      2.830413e-04  2.986963e-04  3.152619e-04  3.327915e-04
## ASV13793    -5.110312e-04 -5.324988e-04 -5.547441e-04 -5.777850e-04
## ASV14482    -6.001652e-05 -6.327735e-05 -6.670784e-05 -7.031498e-05
## ASV15483     3.810887e-04  3.985405e-04  4.167633e-04  4.357889e-04
## ASV2062      2.310194e-03  2.410835e-03  2.515473e-03  2.624239e-03
## ASV2132      1.088789e-03  1.138640e-03  1.190688e-03  1.245022e-03
## ASV2413      1.460377e-03  1.522010e-03  1.585937e-03  1.652222e-03
## ASV2490      9.376312e-04  9.756533e-04  1.014951e-03  1.055548e-03
## ASV2594      5.448817e-04  5.691685e-04  5.944972e-04  6.209114e-04
## ASV2822     -5.113501e-04 -5.328482e-04 -5.551269e-04 -5.782045e-04
## ASV2863      8.820199e-04  9.185798e-04  9.564400e-04  9.956309e-04
## ASV2910      1.146243e-03  1.193520e-03  1.242457e-03  1.293092e-03
## ASV2980      4.161201e-04  4.332395e-04  4.509451e-04  4.692474e-04
## ASV3307      5.110672e-04  5.325412e-04  5.547938e-04  5.778433e-04
## ASV3474      8.785003e-04  9.204799e-04  9.644477e-04  1.010494e-03
## ASV3502      1.715403e-03  1.790783e-03  1.869222e-03  1.950828e-03
## ASV4236      8.253281e-04  8.587927e-04  8.933765e-04  9.290982e-04
## ASV4842     -2.841587e-04 -2.963544e-04 -3.090062e-04 -3.221251e-04
## ASV4894     -5.112966e-04 -5.327927e-04 -5.550695e-04 -5.781456e-04
## ASV5290      6.485464e-04  6.770201e-04  7.066371e-04  7.374340e-04
## ASV5501      1.209737e-04  1.263550e-04  1.319710e-04  1.378324e-04
## ASV5795      4.555344e-04  4.767497e-04  4.989277e-04  5.221094e-04
## ASV5987     -5.113883e-04 -5.328941e-04 -5.551816e-04 -5.782696e-04
## ASV6267     -5.112176e-04 -5.327087e-04 -5.549804e-04 -5.780512e-04
## ASV6862      9.489005e-04  9.865844e-04  1.025478e-03  1.065599e-03
## ASV7145      1.685701e-04  1.750190e-04  1.816688e-04  1.885240e-04
## ASV7673     -5.111610e-04 -5.326467e-04 -5.549125e-04 -5.779769e-04
## ASV7789      2.347344e-04  2.478844e-04  2.618208e-04  2.765920e-04
## ASV7809     -3.889317e-05 -3.892846e-05 -3.882034e-05 -3.855219e-05
## ASV8002     -5.110761e-04 -5.325576e-04 -5.548193e-04 -5.778799e-04
## ASV8205      3.086092e-04  3.224127e-04  3.368085e-04  3.518207e-04
## ASV9155     -3.815788e-04 -3.973855e-04 -4.137443e-04 -4.306662e-04
## ASV9221     -2.976013e-05 -2.907643e-05 -2.818663e-05 -2.706837e-05
## ASV9311     -5.108740e-04 -5.323401e-04 -5.545856e-04 -5.776289e-04
## ASV9557     -5.107036e-04 -5.321551e-04 -5.543847e-04 -5.774110e-04
## ASV9936     -5.105333e-04 -5.319701e-04 -5.541840e-04 -5.771932e-04
## ASV1445      1.243473e-03  1.299935e-03  1.358848e-03  1.420306e-03
## ASV4232      1.082452e-03  1.133759e-03  1.187495e-03  1.243775e-03
## ASV6479      4.331401e-05  4.827578e-05  5.370413e-05  5.963715e-05
## ASV0142     -2.545370e-03 -2.649949e-03 -2.758162e-03 -2.870088e-03
## ASV0378     -8.102230e-04 -8.417785e-04 -8.742559e-04 -9.076558e-04
## ASV1122      1.644591e-03  1.719249e-03  1.797132e-03  1.878365e-03
## ASV0123     -2.490220e-03 -2.592314e-03 -2.697937e-03 -2.807161e-03
## ASV2064      2.389928e-04  2.475890e-04  2.563798e-04  2.653606e-04
## ASV4459     -2.761662e-04 -2.875108e-04 -2.992463e-04 -3.113804e-04
## ASV0448      5.272136e-04  5.546940e-04  5.836535e-04  6.141719e-04
## ASV0397      1.212269e-03  1.266244e-03  1.322462e-03  1.381003e-03
## ASV0485      1.666291e-03  1.738736e-03  1.814067e-03  1.892381e-03
## ASV1566      1.416005e-03  1.478741e-03  1.544052e-03  1.612029e-03
## ASV1365      9.225709e-04  9.637818e-04  1.006714e-03  1.051430e-03
## ASV1065      1.884670e-03  1.968586e-03  2.055994e-03  2.147022e-03
## ASV0722     -2.885010e-05 -2.957146e-05 -3.028607e-05 -3.099204e-05
## ASV12660    -8.322459e-04 -8.660998e-04 -9.011078e-04 -9.372928e-04
## ASV0223     -2.875914e-05 -2.956793e-05 -3.036178e-05 -3.113499e-05
## ASV0229      8.640370e-04  9.039109e-04  9.455704e-04  9.890907e-04
## ASV0877     -2.852100e-04 -2.956527e-04 -3.063497e-04 -3.172976e-04
## ASV0983      1.683496e-03  1.755428e-03  1.830103e-03  1.907598e-03
## ASV0626     -4.854621e-04 -5.019549e-04 -5.187233e-04 -5.357479e-04
## ASV4146     -8.748752e-05 -9.093036e-05 -9.448409e-05 -9.815132e-05
## ASV4175     -1.056743e-03 -1.103425e-03 -1.152013e-03 -1.202570e-03
## ASV2082     -1.133088e-04 -1.208066e-04 -1.288440e-04 -1.374610e-04
## ASV2272      7.840851e-04  8.201869e-04  8.579035e-04  8.973033e-04
## ASV2245     -9.298631e-04 -9.715351e-04 -1.014958e-03 -1.060196e-03
## ASV0590     -6.204141e-04 -6.516874e-04 -6.845711e-04 -7.191478e-04
## ASV0217     -6.960882e-04 -7.170653e-04 -7.380925e-04 -7.591091e-04
## ASV0416      7.791636e-04  8.087192e-04  8.390866e-04  8.702635e-04
## ASV1056      1.084023e-03  1.135883e-03  1.190193e-03  1.247062e-03
## ASV7777     -9.153224e-04 -9.560207e-04 -9.984115e-04 -1.042556e-03
## ASV0455      2.027672e-04  2.127981e-04  2.233147e-04  2.343379e-04
## ASV0604      2.523432e-04  2.667522e-04  2.820162e-04  2.981847e-04
## ASV6100     -8.496314e-04 -8.876976e-04 -9.273735e-04 -9.687201e-04
## ASV11359    -9.346504e-04 -9.754136e-04 -1.017795e-03 -1.061845e-03
## ASV6604      6.939553e-04  7.262637e-04  7.600422e-04  7.953547e-04
## ASV5004     -5.470639e-04 -5.708585e-04 -5.955968e-04 -6.213094e-04
## ASV1483     -5.094728e-04 -5.319265e-04 -5.552945e-04 -5.796081e-04
## ASV9773     -1.084287e-03 -1.132582e-03 -1.182892e-03 -1.235291e-03
## ASV4059      1.358665e-04  1.439827e-04  1.526138e-04  1.617929e-04
## ASV1193      1.755295e-03  1.832802e-03  1.913478e-03  1.997429e-03
## ASV4610     -9.428635e-05 -9.492060e-05 -9.530919e-05 -9.542517e-05
## ASV0742     -5.685175e-04 -5.881598e-04 -6.081582e-04 -6.284913e-04
## ASV1502     -3.824057e-05 -4.167429e-05 -4.539290e-05 -4.941740e-05
## ASV0195     -2.290267e-04 -2.412640e-04 -2.541672e-04 -2.677710e-04
## ASV1213      5.113914e-04  5.311478e-04  5.514733e-04  5.723685e-04
## ASV1648     -7.983997e-04 -8.337354e-04 -8.705312e-04 -9.088401e-04
## ASV6984     -6.050796e-04 -6.323460e-04 -6.607825e-04 -6.904353e-04
## ASV0396     -3.293488e-04 -3.364049e-04 -3.431375e-04 -3.494894e-04
## ASV4297      8.549443e-04  8.898478e-04  9.259491e-04  9.632723e-04
## ASV2622      1.977919e-03  2.060694e-03  2.146485e-03  2.235367e-03
## ASV3512      3.699866e-04  3.899283e-04  4.110107e-04  4.333017e-04
## ASV2411      7.437985e-04  7.791235e-04  8.161051e-04  8.548177e-04
## ASV2291     -2.135284e-04 -2.252130e-04 -2.375744e-04 -2.506527e-04
## ASV0807      9.120187e-04  9.576056e-04  1.005496e-03  1.055802e-03
## ASV1292      4.467447e-04  4.655318e-04  4.850196e-04  5.052284e-04
## ASV1035      1.932726e-04  2.004941e-04  2.079211e-04  2.155561e-04
## ASV0070     -4.110820e-04 -4.243422e-04 -4.377151e-04 -4.511680e-04
## ASV0255      1.970995e-04  2.055997e-04  2.144141e-04  2.235486e-04
## ASV0057     -1.979142e-03 -2.057789e-03 -2.138912e-03 -2.222540e-03
## ASV0077     -2.421631e-04 -2.485802e-04 -2.548939e-04 -2.610712e-04
## ASV0625      2.011477e-03  2.094252e-03  2.179907e-03  2.268503e-03
## ASV2464      9.538257e-04  9.919700e-04  1.031368e-03  1.072040e-03
## ASV1315      1.916498e-03  2.006308e-03  2.100238e-03  2.198468e-03
## ASV2673      1.411380e-03  1.478644e-03  1.549100e-03  1.622899e-03
## ASV2161      5.862752e-04  6.145233e-04  6.441382e-04  6.751855e-04
## ASV0337     -8.676513e-04 -9.050244e-04 -9.438399e-04 -9.841397e-04
## ASV7680     -1.047502e-03 -1.094479e-03 -1.143440e-03 -1.194460e-03
## ASV0611      2.324659e-03  2.431999e-03  2.544162e-03  2.661352e-03
## ASV3118     -7.848302e-04 -8.206645e-04 -8.580634e-04 -8.970890e-04
## ASV1284      8.270106e-04  8.647262e-04  9.040911e-04  9.451714e-04
## ASV0889      6.043230e-04  6.303818e-04  6.574675e-04  6.856143e-04
## ASV4649     -6.438459e-04 -6.723001e-04 -7.019193e-04 -7.327440e-04
## ASV1108     -8.756045e-04 -9.176773e-04 -9.617697e-04 -1.007977e-03
## ASV0738     -3.289293e-06  4.288459e-06  1.283231e-05  2.242886e-05
## ASV0473      1.305153e-04  1.365973e-04  1.429645e-04  1.496308e-04
## ASV0598     -8.626167e-04 -8.963070e-04 -9.310130e-04 -9.667418e-04
## ASV0429      1.463654e-03  1.526524e-03  1.591805e-03  1.659568e-03
## ASV1549      1.580485e-03  1.656258e-03  1.735656e-03  1.818849e-03
## ASV1203      1.116600e-03  1.165284e-03  1.215903e-03  1.268521e-03
## ASV4532      3.418374e-05  3.487256e-05  3.554014e-05  3.618434e-05
## ASV0274     -1.051774e-03 -1.093335e-03 -1.136198e-03 -1.180377e-03
## ASV0163     -1.491881e-03 -1.550143e-03 -1.610162e-03 -1.671954e-03
## ASV1298      6.068589e-04  6.307142e-04  6.553192e-04  6.806847e-04
## ASV9424     -1.403151e-03 -1.467012e-03 -1.533657e-03 -1.603198e-03
## ASV0412      2.088298e-03  2.178771e-03  2.272813e-03  2.370538e-03
## ASV0284      8.898914e-04  9.256594e-04  9.626047e-04  1.000746e-03
## ASV0620     -7.552552e-04 -7.915841e-04 -8.296443e-04 -8.695147e-04
## ASV0153     -1.531495e-03 -1.602887e-03 -1.677518e-03 -1.755526e-03
## ASV0498      2.514552e-04  2.681357e-04  2.859451e-04  3.049548e-04
## ASV0097      1.110606e-03  1.163369e-03  1.218627e-03  1.276496e-03
## ASV0104     -4.847620e-03 -5.060156e-03 -5.281258e-03 -5.511209e-03
## ASV1282      8.638742e-04  9.029861e-04  9.437715e-04  9.862929e-04
## ASV3883     -5.198189e-04 -5.444723e-04 -5.702690e-04 -5.972581e-04
## ASV0801      5.359661e-04  5.624586e-04  5.902630e-04  6.194422e-04
## ASV1611     -1.914912e-03 -2.002026e-03 -2.092931e-03 -2.187775e-03
## ASV0227     -7.481559e-04 -7.854104e-04 -8.245384e-04 -8.656319e-04
## ASV0833      8.007865e-04  8.404203e-04  8.820200e-04  9.256793e-04
## ASV0718      1.759156e-03  1.837691e-03  1.919517e-03  2.004753e-03
## ASV1139      5.666940e-04  5.869694e-04  6.076611e-04  6.287488e-04
## ASV0766     -4.563305e-04 -4.751503e-04 -4.946253e-04 -5.147690e-04
## ASV2091      2.229147e-03  2.320399e-03  2.414793e-03  2.512392e-03
## ASV1238     -8.530225e-05 -8.507045e-05 -8.449292e-05 -8.353107e-05
## ASV9193     -2.641882e-04 -2.792051e-04 -2.951133e-04 -3.119650e-04
## ASV0290     -2.315936e-04 -2.439489e-04 -2.569672e-04 -2.706810e-04
## ASV0231      1.837845e-03  1.918120e-03  2.001614e-03  2.088433e-03
## ASV0185      5.203176e-04  5.556045e-04  5.934061e-04  6.338993e-04
## ASV2330      5.132077e-04  5.344951e-04  5.565408e-04  5.793626e-04
## ASV3119     -6.875974e-04 -7.230868e-04 -7.604687e-04 -7.998451e-04
## ASV2368     -8.872289e-04 -9.292839e-04 -9.733224e-04 -1.019437e-03
## ASV0122     -6.247454e-04 -6.497726e-04 -6.756176e-04 -7.022935e-04
## ASV1044      1.249625e-03  1.310636e-03  1.374643e-03  1.441790e-03
## ASV0160     -1.514589e-03 -1.573307e-03 -1.633746e-03 -1.695913e-03
## ASV0326      1.071942e-03  1.119756e-03  1.169560e-03  1.221424e-03
## ASV1388      1.857124e-03  1.938716e-03  2.023613e-03  2.111928e-03
## ASV0792      2.060008e-03  2.147562e-03  2.238402e-03  2.332617e-03
## ASV0036     -1.373844e-03 -1.437060e-03 -1.503071e-03 -1.571987e-03
## ASV2125      2.169151e-03  2.264295e-03  2.363274e-03  2.466217e-03
## ASV1075      4.412578e-04  4.624050e-04  4.845644e-04  5.077836e-04
## ASV0390      4.722842e-04  4.974219e-04  5.239724e-04  5.520187e-04
## ASV3790     -1.780220e-03 -1.860758e-03 -1.944758e-03 -2.032352e-03
## ASV1535     -1.696735e-04 -1.789668e-04 -1.888024e-04 -1.992131e-04
## ASV0263      3.652693e-04  3.816316e-04  3.986825e-04  4.164475e-04
## ASV0675      3.000900e-03  3.141636e-03  3.288844e-03  3.442808e-03
## ASV3348      3.072044e-04  3.228572e-04  3.393360e-04  3.566855e-04
## ASV0058     -2.716257e-03 -2.834050e-03 -2.956464e-03 -3.083642e-03
## ASV4142      6.748561e-04  7.035986e-04  7.334133e-04  7.643276e-04
## ASV0059     -2.333308e-03 -2.433872e-03 -2.538323e-03 -2.646777e-03
## ASV0013     -4.919692e-03 -5.135385e-03 -5.359778e-03 -5.593161e-03
## ASV0033     -1.501484e-03 -1.570976e-03 -1.643578e-03 -1.719419e-03
## ASV4354     -6.081445e-04 -6.335595e-04 -6.599137e-04 -6.872341e-04
## ASV0022     -1.578606e-03 -1.651280e-03 -1.727170e-03 -1.806406e-03
## ASV0134     -4.187150e-04 -4.396287e-04 -4.615977e-04 -4.846742e-04
## ASV0415     -2.481997e-04 -2.546841e-04 -2.610771e-04 -2.673498e-04
## ASV10103    -1.090862e-03 -1.140231e-03 -1.191720e-03 -1.245410e-03
## ASV1613      1.688802e-03  1.760343e-03  1.834545e-03  1.911474e-03
## ASV0135      1.827179e-06  8.123251e-06  1.522032e-05  2.319211e-05
## ASV0469     -2.098247e-03 -2.186763e-03 -2.278567e-03 -2.373749e-03
## ASV0471      1.385800e-03  1.447680e-03  1.512146e-03  1.579295e-03
## ASV0451     -4.200112e-04 -4.414379e-04 -4.639871e-04 -4.877177e-04
## ASV0747      5.848654e-04  6.138928e-04  6.443708e-04  6.763695e-04
## ASV1314     -8.848695e-04 -9.284302e-04 -9.741801e-04 -1.022232e-03
## ASV0425     -2.329400e-03 -2.424050e-03 -2.521883e-03 -2.622957e-03
## ASV0559     -1.326404e-03 -1.380693e-03 -1.436886e-03 -1.495031e-03
## ASV0148     -1.422943e-03 -1.479707e-03 -1.538272e-03 -1.598657e-03
## ASV0129     -6.505492e-04 -6.725756e-04 -6.949242e-04 -7.175581e-04
## ASV1072      6.813822e-04  7.078904e-04  7.351731e-04  7.632314e-04
## ASV2390      4.856718e-04  5.045009e-04  5.238678e-04  5.437709e-04
## ASV0548      1.607588e-03  1.680142e-03  1.755800e-03  1.834681e-03
## ASV0168     -2.331529e-03 -2.431056e-03 -2.534378e-03 -2.641609e-03
## ASV0066     -1.744966e-03 -1.820394e-03 -1.898763e-03 -1.980159e-03
## ASV0468     -6.550325e-04 -6.840985e-04 -7.143717e-04 -7.458964e-04
## ASV0172     -2.736802e-04 -2.794734e-04 -2.849692e-04 -2.901142e-04
## ASV0236     -7.851044e-04 -8.111014e-04 -8.374300e-04 -8.640433e-04
## ASV0250      1.996313e-04  2.184397e-04  2.388837e-04  2.610922e-04
## ASV0338     -5.056000e-05 -4.791158e-05 -4.477361e-05 -4.110269e-05
## ASV0450     -6.684760e-06 -6.874902e-06 -7.065510e-06 -7.256499e-06
## ASV0377      1.940782e-03  2.026341e-03  2.115390e-03  2.208048e-03
## ASV1022      5.488168e-04  5.736492e-04  5.995603e-04  6.265941e-04
## ASV6174     -1.267464e-04 -1.320038e-04 -1.374604e-04 -1.431236e-04
## ASV0786      1.950710e-04  2.023067e-04  2.097303e-04  2.173406e-04
## ASV0053     -2.346196e-03 -2.450326e-03 -2.558760e-03 -2.671650e-03
## ASV0697     -6.238162e-04 -6.479938e-04 -6.728847e-04 -6.984923e-04
## ASV0785      1.742069e-03  1.819095e-03  1.899282e-03  1.982739e-03
## ASV1967     -1.089299e-03 -1.133734e-03 -1.179706e-03 -1.227249e-03
## ASV0385     -4.877761e-04 -5.061995e-04 -5.251227e-04 -5.445439e-04
## ASV0295      8.636539e-05  9.557813e-05  1.056425e-04  1.166288e-04
## ASV0072     -1.776733e-03 -1.849289e-03 -1.924299e-03 -2.001803e-03
## ASV0157     -6.972992e-04 -7.228726e-04 -7.490217e-04 -7.757245e-04
## ASV0501      9.101414e-04  9.542364e-04  1.000473e-03  1.048954e-03
## ASV10729    -1.446882e-03 -1.512200e-03 -1.580308e-03 -1.651310e-03
## ASV1470      6.518939e-04  6.790059e-04  7.070811e-04  7.361404e-04
## ASV0050     -4.599373e-03 -4.797960e-03 -5.004283e-03 -5.218580e-03
## ASV0411     -8.278881e-05 -8.394586e-05 -8.493414e-05 -8.572996e-05
## ASV0549      9.391634e-04  9.841878e-04  1.031369e-03  1.080808e-03
## ASV0184      5.456689e-04  5.699542e-04  5.952674e-04  6.216495e-04
## ASV0705      6.805186e-04  7.119947e-04  7.448626e-04  7.791765e-04
## ASV1715      1.672053e-03  1.746927e-03  1.824961e-03  1.906271e-03
## ASV0603      2.114711e-04  2.218575e-04  2.327737e-04  2.442489e-04
## ASV0826      5.234225e-04  5.444938e-04  5.662559e-04  5.887191e-04
## ASV0034     -2.044701e-03 -2.130623e-03 -2.219672e-03 -2.311921e-03
## ASV0838      4.335621e-04  4.518209e-04  4.707323e-04  4.903088e-04
## ASV0614     -1.172202e-03 -1.222244e-03 -1.274188e-03 -1.328089e-03
## ASV0014     -4.467557e-03 -4.661104e-03 -4.862256e-03 -5.071251e-03
## ASV0585     -2.923049e-04 -3.056872e-04 -3.196525e-04 -3.342231e-04
## ASV0016     -4.571455e-03 -4.769788e-03 -4.975938e-03 -5.190152e-03
## ASV5394     -1.187463e-03 -1.240768e-03 -1.296320e-03 -1.354201e-03
## ASV0666      9.831350e-04  1.025591e-03  1.069699e-03  1.115508e-03
## ASV2085      3.015484e-04  3.091228e-04  3.165397e-04  3.237583e-04
## ASV0003     -4.163004e-03 -4.342434e-03 -4.528837e-03 -4.722424e-03
## ASV0346      1.314440e-05  1.961936e-05  2.684323e-05  3.487881e-05
## ASV0267     -6.093978e-04 -6.323015e-04 -6.557930e-04 -6.798639e-04
## ASV0353      9.988024e-04  1.049166e-03  1.102127e-03  1.157821e-03
## ASV2419      1.165324e-03  1.214948e-03  1.266457e-03  1.319907e-03
## ASV0447      6.698357e-04  7.058866e-04  7.439429e-04  7.841142e-04
## ASV0654      1.891794e-03  1.977856e-03  2.067631e-03  2.161258e-03
## ASV0151      3.571991e-04  3.776274e-04  3.993113e-04  4.223311e-04
## ASV0065     -1.689335e-03 -1.762635e-03 -1.838812e-03 -1.917956e-03
## ASV0527      1.227284e-03  1.280902e-03  1.336666e-03  1.394644e-03
## ASV4055     -4.950242e-04 -5.190913e-04 -5.443472e-04 -5.708520e-04
## ASV0166     -1.357831e-03 -1.413657e-03 -1.471426e-03 -1.531178e-03
## ASV0417     -1.173747e-03 -1.223821e-03 -1.275804e-03 -1.329755e-03
## ASV0078     -9.143729e-04 -9.513765e-04 -9.895864e-04 -1.029016e-03
## ASV0322     -1.113279e-03 -1.158469e-03 -1.205159e-03 -1.253369e-03
## ASV0156     -1.479008e-03 -1.541581e-03 -1.606497e-03 -1.673824e-03
## ASV0648     -1.412403e-03 -1.477122e-03 -1.544690e-03 -1.615222e-03
## ASV0407      1.336761e-04  1.413918e-04  1.495821e-04  1.582767e-04
## ASV2030     -2.604822e-04 -2.701473e-04 -2.800888e-04 -2.903112e-04
## ASV0300      8.824579e-04  9.262786e-04  9.722991e-04  1.020628e-03
## ASV1150     -7.557157e-05 -7.701795e-05 -7.835602e-05 -7.956765e-05
## ASV0958      9.226980e-04  9.688507e-04  1.017381e-03  1.068416e-03
## ASV0216     -1.374641e-03 -1.430840e-03 -1.488993e-03 -1.549144e-03
## ASV0446      2.122938e-03  2.223429e-03  2.328586e-03  2.438615e-03
## ASV0367     -6.830493e-04 -7.127458e-04 -7.436230e-04 -7.757197e-04
## ASV0200     -1.291655e-03 -1.349067e-03 -1.408875e-03 -1.471166e-03
## ASV0334     -5.494724e-04 -5.665156e-04 -5.836700e-04 -6.008959e-04
## ASV1311      8.871006e-04  9.248871e-04  9.640980e-04  1.004772e-03
## ASV0458      9.700956e-04  1.012373e-03  1.056350e-03  1.102087e-03
## ASV1371      3.432268e-05  3.613122e-05  3.803847e-05  4.004972e-05
## ASV0418      1.201452e-03  1.254819e-03  1.310411e-03  1.368311e-03
## ASV0004      1.415637e-03  1.477708e-03  1.542283e-03  1.609446e-03
## ASV1943      1.007874e-03  1.050609e-03  1.094970e-03  1.141006e-03
## ASV1495     -3.197261e-04 -3.380088e-04 -3.574027e-04 -3.779769e-04
## ASV0901     -1.678943e-03 -1.756954e-03 -1.838505e-03 -1.923748e-03
## ASV0628      9.102078e-04  9.479351e-04  9.869831e-04  1.027377e-03
## ASV0400      3.655340e-04  3.807159e-04  3.964286e-04  4.126821e-04
## ASV0116     -1.321468e-03 -1.384574e-03 -1.450677e-03 -1.519916e-03
## ASV0788      1.035943e-03  1.082164e-03  1.130317e-03  1.180473e-03
## ASV0117      7.198675e-04  7.554190e-04  7.927571e-04  8.319719e-04
## ASV3137      1.745603e-04  1.818673e-04  1.894415e-04  1.972899e-04
## ASV0001      1.620449e-03  1.686522e-03  1.754838e-03  1.825437e-03
## ASV1651      1.082208e-03  1.126568e-03  1.172474e-03  1.219960e-03
## ASV1692      1.283738e-03  1.344791e-03  1.408719e-03  1.475651e-03
## ASV0660      6.310822e-04  6.545508e-04  6.785839e-04  7.031659e-04
## ASV0508      6.211956e-05  6.350368e-05  6.484662e-05  6.614116e-05
## ASV1660     -5.416453e-04 -5.681405e-04 -5.959244e-04 -6.250562e-04
## ASV0233      3.052783e-04  3.206153e-04  3.367519e-04  3.537314e-04
## ASV1343     -1.246933e-03 -1.303530e-03 -1.362582e-03 -1.424187e-03
## ASV0209      1.064877e-03  1.107700e-03  1.151937e-03  1.197609e-03
## ASV0193     -1.418483e-03 -1.477680e-03 -1.539021e-03 -1.602561e-03
## ASV0357     -2.366409e-05 -2.058458e-05 -1.700648e-05 -1.287924e-05
## ASV0198      3.238351e-04  3.387122e-04  3.542537e-04  3.704881e-04
## ASV0007      1.536091e-03  1.598728e-03  1.663491e-03  1.730419e-03
## ASV1772     -1.583640e-04 -1.647862e-04 -1.714072e-04 -1.782263e-04
## ASV0009      1.443705e-03  1.502227e-03  1.562705e-03  1.625171e-03
## ASV0006      5.258648e-04  5.435481e-04  5.614900e-04  5.796627e-04
## ASV0011     -1.757070e-03 -1.837684e-03 -1.921861e-03 -2.009745e-03
## ASV0015      1.192659e-03  1.245071e-03  1.299601e-03  1.356319e-03
## ASV0017      1.258665e-03  1.313752e-03  1.371049e-03  1.430630e-03
## ASV0235     -1.021859e-03 -1.068379e-03 -1.116912e-03 -1.167536e-03
## ASV0382      2.627344e-04  2.794112e-04  2.971687e-04  3.160720e-04
## ASV2357      1.540567e-03  1.610104e-03  1.682629e-03  1.758259e-03
## ASV0567     -1.077845e-03 -1.124131e-03 -1.172231e-03 -1.222204e-03
## ASV0165      1.205246e-03  1.258413e-03  1.313753e-03  1.371341e-03
## ASV0005      2.374199e-03  2.475362e-03  2.580336e-03  2.689226e-03
## ASV0384     -5.946662e-05 -5.842802e-05 -5.701176e-05 -5.517423e-05
## ASV0002      5.637581e-04  5.914726e-04  6.205732e-04  6.511300e-04
## ASV3017      1.364989e-03  1.421986e-03  1.481044e-03  1.542211e-03
## ASV0091      5.691335e-04  5.957832e-04  6.236504e-04  6.527873e-04
## ASV0186     -1.484458e-03 -1.551319e-03 -1.621015e-03 -1.693650e-03
## ASV0370      1.630461e-04  1.711616e-04  1.796914e-04  1.886577e-04
## ASV0018      2.483744e-03  2.590292e-03  2.700921e-03  2.815748e-03
## ASV1377      2.159359e-03  2.251558e-03  2.347272e-03  2.446603e-03
## ASV0019      2.488182e-03  2.595006e-03  2.705930e-03  2.821072e-03
## ASV0023      8.877532e-05  8.727994e-05  8.527150e-05  8.269681e-05
## ASV2194      8.614515e-04  9.018195e-04  9.440514e-04  9.882307e-04
## ASV1155     -5.068324e-05 -5.011554e-05 -4.927574e-05 -4.813374e-05
## ASV0510     -8.293967e-04 -8.597158e-04 -8.907564e-04 -9.225045e-04
## ASV2371     -8.491636e-04 -8.829064e-04 -9.177438e-04 -9.536939e-04
## ASV0024     -3.353708e-05 -4.047391e-05 -4.814998e-05 -5.662659e-05
## ASV2452      1.126394e-03  1.171924e-03  1.218946e-03  1.267480e-03
## ASV2332      1.421521e-04  1.531858e-04  1.650414e-04  1.777739e-04
## ASV2591      1.359730e-04  1.466260e-04  1.580676e-04  1.703487e-04
## ASV0521      1.699180e-03  1.778878e-03  1.862245e-03  1.949442e-03
## ASV5542      5.439160e-04  5.702021e-04  5.977316e-04  6.265587e-04
## ASV0336     -7.558141e-04 -7.887658e-04 -8.230338e-04 -8.586618e-04
## ASV10102     1.159523e-03  1.212553e-03  1.267895e-03  1.325640e-03
## ASV16823    -8.119718e-04 -8.436388e-04 -8.762897e-04 -9.099382e-04
## ASV3104      8.117270e-04  8.433749e-04  8.760055e-04  9.096322e-04
## ASV0781      4.164499e-04  4.340614e-04  4.523236e-04  4.712532e-04
## ASV10899     4.919576e-04  5.184298e-04  5.463747e-04  5.758736e-04
## ASV11222    -8.116009e-04 -8.432416e-04 -8.758647e-04 -9.094837e-04
## ASV11327    -8.113563e-04 -8.429779e-04 -8.755807e-04 -9.091780e-04
## ASV12458    -8.111119e-04 -8.427144e-04 -8.752968e-04 -9.088725e-04
## ASV1636     -6.572526e-04 -6.823797e-04 -7.082345e-04 -7.348216e-04
## ASV1890     -8.252441e-04 -8.585721e-04 -8.930494e-04 -9.287043e-04
## ASV2898      1.857939e-03  1.936767e-03  2.018548e-03  2.103362e-03
## ASV8328     -5.285704e-05 -4.960336e-05 -4.576836e-05 -4.129819e-05
## ASV0709     -1.528187e-03 -1.593483e-03 -1.661253e-03 -1.731566e-03
## ASV0856      2.838125e-04  2.983858e-04  3.137222e-04  3.298609e-04
## ASV0909     -5.439025e-04 -5.609133e-04 -5.780427e-04 -5.952508e-04
## ASV0937     -1.238209e-03 -1.294423e-03 -1.353106e-03 -1.414361e-03
## ASV11390    -8.106147e-04 -8.421800e-04 -8.747227e-04 -9.082562e-04
## ASV11966     5.080525e-04  5.336748e-04  5.605976e-04  5.888844e-04
## ASV12990     2.481643e-04  2.593496e-04  2.709929e-04  2.831085e-04
## ASV14797     8.710146e-04  9.066122e-04  9.434249e-04  9.814760e-04
## ASV14904    -8.105871e-04 -8.421527e-04 -8.746961e-04 -9.082306e-04
## ASV15304     3.041591e-04  3.212669e-04  3.393613e-04  3.584968e-04
## ASV16696    -8.104179e-04 -8.419724e-04 -8.745042e-04 -9.080266e-04
## ASV1690      5.322378e-04  5.597338e-04  5.886526e-04  6.190626e-04
## ASV2029      2.414601e-03  2.518989e-03  2.627470e-03  2.740172e-03
## ASV2834      1.325996e-03  1.385393e-03  1.447305e-03  1.511827e-03
## ASV4003      4.705664e-04  4.968807e-04  5.247291e-04  5.542011e-04
## ASV4064      9.531015e-04  9.970721e-04  1.042983e-03  1.090912e-03
## ASV4294      3.890893e-04  4.104816e-04  4.330994e-04  4.570133e-04
## ASV4609     -1.528018e-05 -1.482170e-05 -1.426256e-05 -1.359379e-05
## ASV6283     -8.105265e-04 -8.420988e-04 -8.746508e-04 -9.081963e-04
## ASV6491     -8.102824e-04 -8.418357e-04 -8.743674e-04 -9.078913e-04
## ASV7453      4.253322e-04  4.484155e-04  4.727868e-04  4.985161e-04
## ASV7959      1.424563e-04  1.528886e-04  1.640728e-04  1.760584e-04
## ASV8219      8.101802e-04  8.417301e-04  8.742588e-04  9.077800e-04
## ASV8547     -8.099363e-04 -8.414672e-04 -8.739756e-04 -9.074752e-04
## ASV9319      6.318000e-04  6.615268e-04  6.926182e-04  7.251333e-04
## ASV9382     -8.098159e-04 -8.413393e-04 -8.738399e-04 -9.073315e-04
## ASV11516    -8.095722e-04 -8.410766e-04 -8.735570e-04 -9.070269e-04
## ASV14377    -8.093287e-04 -8.408141e-04 -8.732742e-04 -9.067225e-04
## ASV1867      1.336450e-03  1.397629e-03  1.461486e-03  1.528127e-03
## ASV1895     -2.695833e-04 -2.797265e-04 -2.901628e-04 -3.008958e-04
## ASV3168      5.288747e-04  5.504573e-04  5.727456e-04  5.957469e-04
## ASV4449      1.042697e-03  1.085458e-03  1.129741e-03  1.175585e-03
## ASV6596      7.158144e-04  7.523270e-04  7.907515e-04  8.311887e-04
## ASV7492     -2.409754e-04 -2.465746e-04 -2.520138e-04 -2.572604e-04
## ASV9854     -4.027603e-04 -4.176850e-04 -4.330182e-04 -4.487621e-04
## ASV6296      8.088855e-04  8.403407e-04  8.727692e-04  9.061843e-04
## ASV4201      3.993144e-04  4.232270e-04  4.486282e-04  4.756088e-04
## ASV0552      2.245456e-03  2.348885e-03  2.456902e-03  2.569692e-03
## ASV3671     -1.178956e-04 -1.196293e-04 -1.211842e-04 -1.225393e-04
## ASV3529     -1.091785e-04 -1.093241e-04 -1.091305e-04 -1.085639e-04
## ASV1060      5.730337e-04  6.000413e-04  6.283197e-04  6.579294e-04
## ASV0239     -1.140541e-03 -1.185114e-03 -1.231033e-03 -1.278308e-03
## ASV5711     -1.072606e-03 -1.116395e-03 -1.161719e-03 -1.208616e-03
## ASV4152     -1.467484e-03 -1.530315e-03 -1.595582e-03 -1.663360e-03
## ASV1461      1.250290e-03  1.300010e-03  1.351306e-03  1.404200e-03
## ASV2877      1.069429e-03  1.115009e-03  1.162300e-03  1.211348e-03
## ASV0012      8.765917e-04  9.187196e-04  9.628676e-04  1.009131e-03
## ASV9823      2.628506e-04  2.723290e-04  2.820089e-04  2.918817e-04
## ASV0008      9.455140e-04  9.902896e-04  1.037165e-03  1.086235e-03
## ASV7832     -8.894160e-04 -9.268230e-04 -9.656408e-04 -1.005912e-03
## ASV1915      1.090116e-04  1.157212e-04  1.228344e-04  1.303717e-04
## ASV0055      6.320275e-04  6.595486e-04  6.881553e-04  7.178807e-04
## ASV0032      1.480888e-03  1.542671e-03  1.606689e-03  1.672996e-03
## ASV2977     -1.234180e-03 -1.286904e-03 -1.341659e-03 -1.398509e-03
## ASV0466      1.209768e-03  1.258840e-03  1.309569e-03  1.361986e-03
## ASV3866      1.383512e-03  1.446488e-03  1.512206e-03  1.580774e-03
## ASV0040      1.869488e-03  1.956406e-03  2.047259e-03  2.142214e-03
## ASV0496     -1.733142e-04 -1.856004e-04 -1.987782e-04 -2.129095e-04
## ASV0052      2.152356e-03  2.245027e-03  2.341280e-03  2.441222e-03
## ASV3828     -1.307464e-03 -1.363144e-03 -1.420981e-03 -1.481044e-03
## ASV1930      8.434150e-04  8.805310e-04  9.191255e-04  9.592433e-04
## ASV2126      1.353832e-03  1.412672e-03  1.473831e-03  1.537384e-03
## ASV0793      9.056198e-04  9.506207e-04  9.978787e-04  1.047504e-03
## ASV0299     -4.953638e-04 -5.127993e-04 -5.306125e-04 -5.487949e-04
## ASV0208      1.347450e-03  1.411465e-03  1.478500e-03  1.548694e-03
## ASV0511     -5.928034e-04 -6.127681e-04 -6.330311e-04 -6.535629e-04
## ASV1123     -8.361590e-04 -8.683906e-04 -9.015647e-04 -9.356864e-04
## ASV0099     -4.792465e-04 -4.986527e-04 -5.186666e-04 -5.392893e-04
## ASV0752     -1.398569e-04 -1.480234e-04 -1.566689e-04 -1.658193e-04
## ASV0883      3.629151e-05  3.919030e-05  4.230715e-05  4.565646e-05
## ASV0683      1.197281e-03  1.253647e-03  1.312612e-03  1.374291e-03
## ASV4117     -1.320733e-03 -1.377220e-03 -1.435908e-03 -1.496870e-03
## ASV2172      5.122224e-04  5.351208e-04  5.589777e-04  5.838283e-04
## ASV0330     -9.331348e-04 -9.750351e-04 -1.018702e-03 -1.064200e-03
## ASV0728      9.244730e-04  9.681351e-04  1.013799e-03  1.061550e-03
## ASV0499      1.809011e-03  1.894559e-03  1.984111e-03  2.077851e-03
## ASV0120     -1.904021e-03 -1.987492e-03 -2.074303e-03 -2.164560e-03
## ASV1446      9.951185e-05  1.003953e-04  1.010251e-04  1.013691e-04
## ASV17171    -1.263019e-03 -1.317577e-03 -1.374309e-03 -1.433290e-03
## ASV0533      3.943917e-04  4.136531e-04  4.338662e-04  4.550782e-04
## ASV2495     -5.463624e-04 -5.723118e-04 -5.995146e-04 -6.280339e-04
## ASV5582      4.035793e-04  4.182388e-04  4.332372e-04  4.485664e-04
## ASV1488      4.408044e-04  4.617988e-04  4.837729e-04  5.067691e-04
## ASV0682      1.257630e-03  1.316942e-03  1.379011e-03  1.443960e-03
## ASV0068     -1.303992e-04 -1.396303e-04 -1.495177e-04 -1.601041e-04
## ASV1987     -7.233602e-04 -7.597963e-04 -7.980968e-04 -8.383560e-04
## ASV0035      1.254220e-04  1.244549e-04  1.228581e-04  1.205564e-04
## ASV7192     -8.094552e-04 -8.417678e-04 -8.751321e-04 -9.095643e-04
## ASV0873      7.789289e-05  7.854287e-05  7.901558e-05  7.929217e-05
## ASV4749     -2.067776e-05 -2.741058e-05 -3.491713e-05 -4.326497e-05
## ASV2174      7.544344e-04  7.835822e-04  8.135978e-04  8.444891e-04
## ASV1476     -7.261693e-04 -7.591211e-04 -7.935301e-04 -8.294594e-04
## ASV0740     -1.820287e-03 -1.905489e-03 -1.994593e-03 -2.087770e-03
## ASV0170      3.724874e-04  3.891133e-04  4.064439e-04  4.245065e-04
## ASV2466     -1.579124e-03 -1.648939e-03 -1.721664e-03 -1.797409e-03
## ASV1709      1.204537e-03  1.256368e-03  1.310226e-03  1.366177e-03
## ASV6170     -1.155446e-03 -1.208025e-03 -1.262889e-03 -1.320130e-03
## ASV3673      1.325553e-03  1.386058e-03  1.449210e-03  1.515115e-03
## ASV1745      1.034501e-04  1.082276e-04  1.132133e-04  1.184150e-04
##                                                                    
## (Intercept) -1.570570e-04 -1.765259e-04 -1.982285e-04 -2.223921e-04
## ASV1236      1.042706e-03  1.084673e-03  1.128039e-03  1.172831e-03
## ASV0421     -1.875735e-03 -1.952364e-03 -2.031627e-03 -2.113577e-03
## ASV0691     -1.551297e-03 -1.610111e-03 -1.670602e-03 -1.732783e-03
## ASV0899      2.802421e-05  3.185851e-05  3.600621e-05  4.048316e-05
## ASV1004      2.134214e-03  2.221427e-03  2.311625e-03  2.404867e-03
## ASV1041     -1.445572e-03 -1.504509e-03 -1.565428e-03 -1.628364e-03
## ASV1058      1.987958e-03  2.069643e-03  2.154187e-03  2.241654e-03
## ASV12542     5.709903e-04  5.922215e-04  6.140227e-04  6.363945e-04
## ASV1294      2.350835e-03  2.449674e-03  2.552151e-03  2.658360e-03
## ASV13113     9.283744e-04  9.726679e-04  1.019069e-03  1.067677e-03
## ASV1318      2.017530e-03  2.100425e-03  2.186206e-03  2.274933e-03
## ASV2269     -6.025172e-04 -6.272560e-04 -6.528435e-04 -6.792955e-04
## ASV2542      1.410665e-03  1.475616e-03  1.543452e-03  1.614295e-03
## ASV2660     -1.135434e-03 -1.180431e-03 -1.226856e-03 -1.274728e-03
## ASV2737     -8.755897e-05 -9.257585e-05 -9.786738e-05 -1.034454e-04
## ASV2840      1.493399e-03  1.551448e-03  1.611230e-03  1.672758e-03
## ASV3053      7.383851e-05  7.641053e-05  7.904795e-05  8.175192e-05
## ASV3077      4.724981e-04  4.914786e-04  5.110978e-04  5.313696e-04
## ASV3134      1.850801e-03  1.938013e-03  2.029288e-03  2.124811e-03
## ASV3140      7.909507e-04  8.267082e-04  8.639799e-04  9.028204e-04
## ASV3579      3.791495e-04  3.999407e-04  4.219290e-04  4.451838e-04
## ASV6119     -6.020896e-04 -6.267954e-04 -6.523478e-04 -6.787627e-04
## ASV7557     -6.018531e-04 -6.265391e-04 -6.520701e-04 -6.784620e-04
## ASV8422      3.140510e-04  3.259718e-04  3.382453e-04  3.508764e-04
## ASV1086     -1.566212e-04 -1.625348e-04 -1.686247e-04 -1.748940e-04
## ASV1310      1.166328e-03  1.215422e-03  1.266311e-03  1.319038e-03
## ASV15750    -2.748871e-04 -2.854823e-04 -2.963749e-04 -3.075640e-04
## ASV16905    -6.017592e-04 -6.264375e-04 -6.519604e-04 -6.783436e-04
## ASV2033      1.245957e-03  1.304049e-03  1.364767e-03  1.428221e-03
## ASV2089      4.153829e-04  4.325693e-04  4.503521e-04  4.687428e-04
## ASV2127      1.655815e-03  1.724569e-03  1.795786e-03  1.869526e-03
## ASV2725      1.811027e-03  1.882532e-03  1.956290e-03  2.032330e-03
## ASV2804     -6.017358e-04 -6.264147e-04 -6.519386e-04 -6.783232e-04
## ASV3075      1.215997e-03  1.268502e-03  1.323108e-03  1.379889e-03
## ASV3327      1.202807e-03  1.258205e-03  1.316068e-03  1.376496e-03
## ASV3342      1.279164e-03  1.336228e-03  1.395675e-03  1.457590e-03
## ASV3532     -1.151822e-03 -1.203176e-03 -1.256686e-03 -1.312433e-03
## ASV3600      1.451179e-03  1.515401e-03  1.582279e-03  1.651909e-03
## ASV4013      1.175468e-03  1.224811e-03  1.275963e-03  1.328971e-03
## ASV4136      1.132756e-03  1.178488e-03  1.225765e-03  1.274616e-03
## ASV4195      6.014190e-04  6.260727e-04  6.515696e-04  6.779255e-04
## ASV4407     -6.011829e-04 -6.258169e-04 -6.512926e-04 -6.776255e-04
## ASV4717      9.428067e-06  8.561039e-06  7.578210e-06  6.472348e-06
## ASV6794      5.868110e-04  6.092568e-04  6.323819e-04  6.561970e-04
## ASV8324     -6.010894e-04 -6.257142e-04 -6.511798e-04 -6.775019e-04
## ASV8981     -1.209758e-04 -1.233869e-04 -1.256434e-04 -1.277193e-04
## ASV9859      5.564250e-04  5.853298e-04  6.158065e-04  6.479439e-04
## ASV0936     -9.566527e-04 -9.968129e-04 -1.038451e-03 -1.081606e-03
## ASV12683    -1.174643e-04 -1.233601e-04 -1.295357e-04 -1.360014e-04
## ASV1293      1.383280e-03  1.439592e-03  1.497824e-03  1.558017e-03
## ASV13055    -1.317353e-04 -1.361625e-04 -1.406487e-04 -1.451860e-04
## ASV17063    -6.007745e-04 -6.253795e-04 -6.508247e-04 -6.771259e-04
## ASV2228      6.005389e-04  6.251242e-04  6.505482e-04  6.768265e-04
## ASV2769     -7.472644e-05 -7.562365e-05 -7.636587e-05 -7.693434e-05
## ASV2803      2.631989e-04  2.728094e-04  2.826708e-04  2.927834e-04
## ASV2896      8.022779e-04  8.384873e-04  8.762934e-04  9.157669e-04
## ASV3062      2.987748e-04  3.152434e-04  3.326646e-04  3.510937e-04
## ASV3107      9.619747e-04  1.004778e-03  1.049375e-03  1.095834e-03
## ASV3265      1.794326e-03  1.867067e-03  1.942259e-03  2.019948e-03
## ASV3666     -5.005073e-05 -5.266273e-05 -5.541862e-05 -5.832704e-05
## ASV4497      4.285499e-04  4.461810e-04  4.644324e-04  4.833182e-04
## ASV6914     -2.243888e-04 -2.343639e-04 -2.447449e-04 -2.555447e-04
## ASV0576     -2.047147e-03 -2.126274e-03 -2.207784e-03 -2.291702e-03
## ASV0673      6.291494e-04  6.591352e-04  6.904863e-04  7.232550e-04
## ASV0772      6.691889e-04  6.981345e-04  7.282316e-04  7.595193e-04
## ASV0862     -4.715450e-04 -4.880502e-04 -5.048839e-04 -5.220322e-04
## ASV0898      6.134986e-04  6.432933e-04  6.745110e-04  7.072144e-04
## ASV0910      1.290412e-03  1.351495e-03  1.415412e-03  1.482287e-03
## ASV0964     -7.509325e-04 -7.803850e-04 -8.107413e-04 -8.420099e-04
## ASV10059     6.147591e-04  6.446262e-04  6.759555e-04  7.088179e-04
## ASV10263    -6.019204e-04 -6.266295e-04 -6.521881e-04 -6.786127e-04
## ASV1088      6.945321e-04  7.281846e-04  7.634914e-04  8.005350e-04
## ASV1101      1.069387e-03  1.114551e-03  1.161358e-03  1.209843e-03
## ASV1183      7.018057e-04  7.326156e-04  7.646642e-04  7.979926e-04
## ASV11956     2.289522e-04  2.366851e-04  2.445674e-04  2.525951e-04
## ASV12774    -1.085338e-04 -1.139937e-04 -1.197238e-04 -1.257364e-04
## ASV1321      3.513413e-04  3.709706e-04  3.917413e-04  4.137189e-04
## ASV13793    -6.016395e-04 -6.263248e-04 -6.518579e-04 -6.782550e-04
## ASV14482    -7.410582e-05 -7.808738e-05 -8.226666e-05 -8.665060e-05
## ASV15483     4.556496e-04  4.763792e-04  4.980123e-04  5.205848e-04
## ASV2062      2.737262e-03  2.854675e-03  2.976611e-03  3.103205e-03
## ASV2132      1.301734e-03  1.360920e-03  1.422679e-03  1.487111e-03
## ASV2413      1.720926e-03  1.792114e-03  1.865849e-03  1.942195e-03
## ASV2490      1.097464e-03  1.140720e-03  1.185335e-03  1.231328e-03
## ASV2594      6.484567e-04  6.771808e-04  7.071338e-04  7.383679e-04
## ASV2822     -6.020991e-04 -6.268285e-04 -6.524098e-04 -6.788599e-04
## ASV2863      1.036183e-03  1.078125e-03  1.121487e-03  1.166298e-03
## ASV2910      1.345461e-03  1.399599e-03  1.455541e-03  1.513321e-03
## ASV2980      4.881562e-04  5.076806e-04  5.278289e-04  5.486089e-04
## ASV3307      6.017076e-04  6.264044e-04  6.519506e-04  6.783629e-04
## ASV3474      1.058713e-03  1.109202e-03  1.162062e-03  1.217398e-03
## ASV3502      2.035706e-03  2.123967e-03  2.215722e-03  2.311087e-03
## ASV4236      9.659760e-04  1.004026e-03  1.043265e-03  1.083706e-03
## ASV4842     -3.357217e-04 -3.498064e-04 -3.643890e-04 -3.794791e-04
## ASV4894     -6.020391e-04 -6.267678e-04 -6.523490e-04 -6.787997e-04
## ASV5290      7.694475e-04  8.027148e-04  8.372733e-04  8.731602e-04
## ASV5501      1.439504e-04  1.503369e-04  1.570042e-04  1.639656e-04
## ASV5795      5.463371e-04  5.716545e-04  5.981069e-04  6.257410e-04
## ASV5987     -6.021762e-04 -6.269194e-04 -6.525166e-04 -6.789850e-04
## ASV6267     -6.019394e-04 -6.266626e-04 -6.522384e-04 -6.786837e-04
## ASV6862      1.106967e-03  1.149596e-03  1.193502e-03  1.238699e-03
## ASV7145      1.955892e-04  2.028692e-04  2.103692e-04  2.180947e-04
## ASV7673     -6.018581e-04 -6.265738e-04 -6.521414e-04 -6.785778e-04
## ASV7789      2.922496e-04  3.088480e-04  3.264445e-04  3.451000e-04
## ASV7809     -3.810620e-05 -3.746329e-05 -3.660310e-05 -3.550398e-05
## ASV8002     -6.017574e-04 -6.264698e-04 -6.520346e-04 -6.784687e-04
## ASV8205      3.674745e-04  3.837958e-04  4.008118e-04  4.185507e-04
## ASV9155     -4.481618e-04 -4.662412e-04 -4.849141e-04 -5.041894e-04
## ASV9221     -2.569755e-05 -2.404823e-05 -2.209259e-05 -1.980080e-05
## ASV9311     -6.014883e-04 -6.261815e-04 -6.517261e-04 -6.781391e-04
## ASV9557     -6.012519e-04 -6.259253e-04 -6.514485e-04 -6.778385e-04
## ASV9936     -6.010157e-04 -6.256693e-04 -6.511711e-04 -6.775381e-04
## ASV1445      1.484411e-03  1.551266e-03  1.620976e-03  1.693653e-03
## ASV4232      1.302720e-03  1.364456e-03  1.429115e-03  1.496836e-03
## ASV6479      6.611552e-05  7.318266e-05  8.088483e-05  8.927128e-05
## ASV0142     -2.985800e-03 -3.105371e-03 -3.228873e-03 -3.356372e-03
## ASV0378     -9.419764e-04 -9.772131e-04 -1.013358e-03 -1.050401e-03
## ASV1122      1.963076e-03  2.051398e-03  2.143468e-03  2.239423e-03
## ASV0123     -2.920058e-03 -3.036695e-03 -3.157139e-03 -3.281453e-03
## ASV2064      2.745255e-04  2.838678e-04  2.933799e-04  3.030533e-04
## ASV4459     -3.239208e-04 -3.368749e-04 -3.502499e-04 -3.640529e-04
## ASV0448      6.463328e-04  6.802240e-04  7.159374e-04  7.535691e-04
## ASV0397      1.441950e-03  1.505386e-03  1.571397e-03  1.640071e-03
## ASV0485      1.973776e-03  2.058353e-03  2.146214e-03  2.237464e-03
## ASV1566      1.682761e-03  1.756340e-03  1.832861e-03  1.912419e-03
## ASV1365      1.097991e-03  1.146463e-03  1.196909e-03  1.249397e-03
## ASV1065      2.241797e-03  2.340453e-03  2.443124e-03  2.549951e-03
## ASV0722     -3.168749e-05 -3.237053e-05 -3.303937e-05 -3.369224e-05
## ASV12660    -9.746774e-04 -1.013283e-03 -1.053131e-03 -1.094242e-03
## ASV0223     -3.188116e-05 -3.259311e-05 -3.326279e-05 -3.388125e-05
## ASV0229      1.034550e-03  1.082030e-03  1.131613e-03  1.183388e-03
## ASV0877     -3.284922e-04 -3.399285e-04 -3.516007e-04 -3.635024e-04
## ASV0983      1.987994e-03  2.071372e-03  2.157812e-03  2.247395e-03
## ASV0626     -5.530068e-04 -5.704759e-04 -5.881289e-04 -6.059370e-04
## ASV4146     -1.019349e-04 -1.058377e-04 -1.098633e-04 -1.140153e-04
## ASV4175     -1.255162e-03 -1.309858e-03 -1.366725e-03 -1.425832e-03
## ASV2082     -1.467002e-04 -1.566072e-04 -1.672307e-04 -1.786225e-04
## ASV2272      9.384571e-04  9.814387e-04  1.026324e-03  1.073193e-03
## ASV2245     -1.107313e-03 -1.156378e-03 -1.207459e-03 -1.260626e-03
## ASV0590     -7.555039e-04 -7.937296e-04 -8.339192e-04 -8.761711e-04
## ASV0217     -7.800486e-04 -8.008387e-04 -8.214008e-04 -8.416498e-04
## ASV0416      9.022456e-04  9.350260e-04  9.685956e-04  1.002943e-03
## ASV1056      1.306601e-03  1.368929e-03  1.434165e-03  1.502436e-03
## ASV7777     -1.088518e-03 -1.136363e-03 -1.186157e-03 -1.237969e-03
## ASV0455      2.458888e-04  2.579892e-04  2.706611e-04  2.839268e-04
## ASV0604      3.153093e-04  3.334442e-04  3.526459e-04  3.729734e-04
## ASV6100     -1.011800e-03 -1.056680e-03 -1.103424e-03 -1.152104e-03
## ASV11359    -1.107617e-03 -1.155163e-03 -1.204534e-03 -1.255786e-03
## ASV6604      8.322672e-04  8.708485e-04  9.111697e-04  9.533048e-04
## ASV5004     -6.480277e-04 -6.757836e-04 -7.046095e-04 -7.345387e-04
## ASV1483     -6.048996e-04 -6.312018e-04 -6.585482e-04 -6.869732e-04
## ASV9773     -1.289853e-03 -1.346658e-03 -1.405784e-03 -1.467314e-03
## ASV4059      1.715545e-04  1.819355e-04  1.929744e-04  2.047120e-04
## ASV1193      2.084769e-03  2.175610e-03  2.270068e-03  2.368261e-03
## ASV4610     -9.524006e-05 -9.472380e-05 -9.384475e-05 -9.256976e-05
## ASV0742     -6.491350e-04 -6.700625e-04 -6.912441e-04 -7.126471e-04
## ASV1502     -5.377004e-05 -5.847435e-05 -6.355515e-05 -6.903859e-05
## ASV0195     -2.821115e-04 -2.972265e-04 -3.131549e-04 -3.299374e-04
## ASV1213      5.938326e-04  6.158632e-04  6.384564e-04  6.616063e-04
## ASV1648     -9.487167e-04 -9.902172e-04 -1.033400e-03 -1.078323e-03
## ASV6984     -7.213523e-04 -7.535833e-04 -7.871798e-04 -8.221953e-04
## ASV0396     -3.553987e-04 -3.607995e-04 -3.656208e-04 -3.697875e-04
## ASV4297      1.001841e-03  1.041679e-03  1.082808e-03  1.125249e-03
## ASV2622      2.327418e-03  2.422713e-03  2.521328e-03  2.623339e-03
## ASV3512      4.568737e-04  4.818030e-04  5.081704e-04  5.360616e-04
## ASV2411      8.953387e-04  9.377486e-04  9.821308e-04  1.028572e-03
## ASV2291     -2.644904e-04 -2.791322e-04 -2.946252e-04 -3.110188e-04
## ASV0807      1.108643e-03  1.164140e-03  1.222421e-03  1.283618e-03
## ASV1292      5.261790e-04  5.478923e-04  5.703899e-04  5.936934e-04
## ASV1035      2.234014e-04  2.314597e-04  2.397333e-04  2.482250e-04
## ASV0070     -4.646646e-04 -4.781645e-04 -4.916233e-04 -5.049919e-04
## ASV0255      2.330081e-04  2.427969e-04  2.529182e-04  2.633742e-04
## ASV0057     -2.308692e-03 -2.397388e-03 -2.488640e-03 -2.582456e-03
## ASV0077     -2.670759e-04 -2.728689e-04 -2.784076e-04 -2.836463e-04
## ASV0625      2.360098e-03  2.454748e-03  2.552508e-03  2.653429e-03
## ASV2464      1.114009e-03  1.157295e-03  1.201915e-03  1.247889e-03
## ASV1315      2.301183e-03  2.408577e-03  2.520848e-03  2.638204e-03
## ASV2673      1.700196e-03  1.781154e-03  1.865942e-03  1.954736e-03
## ASV2161      7.077339e-04  7.418553e-04  7.776248e-04  8.151209e-04
## ASV0337     -1.025966e-03 -1.069361e-03 -1.114366e-03 -1.161024e-03
## ASV7680     -1.247615e-03 -1.302985e-03 -1.360649e-03 -1.420690e-03
## ASV0611      2.783784e-03  2.911681e-03  3.045272e-03  3.184798e-03
## ASV3118     -9.378054e-04 -9.802784e-04 -1.024576e-03 -1.070769e-03
## ASV1284      9.880357e-04  1.032755e-03  1.079402e-03  1.128052e-03
## ASV0889      7.148572e-04  7.452319e-04  7.767753e-04  8.095250e-04
## ASV4649     -7.648156e-04 -7.981764e-04 -8.328695e-04 -8.689391e-04
## ASV1108     -1.056399e-03 -1.107139e-03 -1.160305e-03 -1.216011e-03
## ASV0738      3.317069e-05  4.515669e-05  5.849230e-05  7.328978e-05
## ASV0473      1.566108e-04  1.639198e-04  1.715740e-04  1.795904e-04
## ASV0598     -1.003499e-03 -1.041288e-03 -1.080111e-03 -1.119967e-03
## ASV0429      1.729881e-03  1.802814e-03  1.878437e-03  1.956819e-03
## ASV1549      1.906014e-03  1.997337e-03  2.093010e-03  2.193235e-03
## ASV1203      1.323199e-03  1.380001e-03  1.438993e-03  1.500238e-03
## ASV4532      3.680316e-05  3.739486e-05  3.795799e-05  3.849146e-05
## ASV0274     -1.225885e-03 -1.272734e-03 -1.320933e-03 -1.370490e-03
## ASV0163     -1.735528e-03 -1.800891e-03 -1.868048e-03 -1.936999e-03
## ASV1298      7.068213e-04  7.337389e-04  7.614472e-04  7.899552e-04
## ASV9424     -1.675749e-03 -1.751431e-03 -1.830366e-03 -1.912682e-03
## ASV0412      2.472062e-03  2.577502e-03  2.686979e-03  2.800612e-03
## ASV0284      1.040102e-03  1.080689e-03  1.122522e-03  1.165615e-03
## ASV0620     -9.112768e-04 -9.550154e-04 -1.000818e-03 -1.048776e-03
## ASV0153     -1.837054e-03 -1.922247e-03 -2.011259e-03 -2.104246e-03
## ASV0498      3.252394e-04  3.468774e-04  3.699504e-04  3.945438e-04
## ASV0097      1.337098e-03  1.400560e-03  1.467013e-03  1.536594e-03
## ASV0104     -5.750301e-03 -5.998828e-03 -6.257091e-03 -6.525394e-03
## ASV1282      1.030614e-03  1.076801e-03  1.124919e-03  1.175037e-03
## ASV3883     -6.254900e-04 -6.550167e-04 -6.858920e-04 -7.181706e-04
## ASV0801      6.500616e-04  6.821897e-04  7.158975e-04  7.512591e-04
## ASV1611     -2.286716e-03 -2.389913e-03 -2.497532e-03 -2.609744e-03
## ASV0227     -9.087873e-04 -9.541046e-04 -1.001688e-03 -1.051647e-03
## ASV0833      9.714954e-04  1.019570e-03  1.070007e-03  1.122916e-03
## ASV0718      2.093523e-03  2.185953e-03  2.282173e-03  2.382314e-03
## ASV1139      6.502093e-04  6.720157e-04  6.941376e-04  7.165406e-04
## ASV0766     -5.355945e-04 -5.571146e-04 -5.793416e-04 -6.022874e-04
## ASV2091      2.613258e-03  2.717451e-03  2.825027e-03  2.936042e-03
## ASV1238     -8.214357e-05 -8.028619e-05 -7.791170e-05 -7.496981e-05
## ASV9193     -3.298152e-04 -3.487216e-04 -3.687448e-04 -3.899481e-04
## ASV0290     -2.851234e-04 -3.003285e-04 -3.163310e-04 -3.331662e-04
## ASV0231      2.178685e-03  2.272482e-03  2.369935e-03  2.471159e-03
## ASV0185      6.772727e-04  7.237264e-04  7.734729e-04  8.267379e-04
## ASV2330      6.029780e-04  6.274046e-04  6.526594e-04  6.787595e-04
## ASV3119     -8.413228e-04 -8.850140e-04 -9.310365e-04 -9.795135e-04
## ASV2368     -1.067724e-03 -1.118286e-03 -1.171228e-03 -1.226661e-03
## ASV0122     -7.298124e-04 -7.581859e-04 -7.874246e-04 -8.175381e-04
## ASV1044      1.512228e-03  1.586116e-03  1.663616e-03  1.744901e-03
## ASV0160     -1.759810e-03 -1.825436e-03 -1.892786e-03 -1.961851e-03
## ASV0326      1.275420e-03  1.331621e-03  1.390103e-03  1.450939e-03
## ASV1388      2.203776e-03  2.299273e-03  2.398540e-03  2.501696e-03
## ASV0792      2.430293e-03  2.531520e-03  2.636385e-03  2.744974e-03
## ASV0036     -1.643924e-03 -1.719000e-03 -1.797337e-03 -1.879059e-03
## ASV2125      2.573253e-03  2.684514e-03  2.800133e-03  2.920247e-03
## ASV1075      5.321123e-04  5.576022e-04  5.843075e-04  6.122842e-04
## ASV0390      5.816486e-04  6.129549e-04  6.460360e-04  6.809956e-04
## ASV3790     -2.123678e-03 -2.218878e-03 -2.318098e-03 -2.421487e-03
## ASV1535     -2.102337e-04 -2.219008e-04 -2.342532e-04 -2.473317e-04
## ASV0263      4.349527e-04  4.542250e-04  4.742919e-04  4.951816e-04
## ASV0675      3.603823e-03  3.772195e-03  3.948242e-03  4.132292e-03
## ASV3348      3.749527e-04  3.941869e-04  4.144400e-04  4.357665e-04
## ASV0058     -3.215725e-03 -3.352859e-03 -3.495188e-03 -3.642857e-03
## ASV4142      7.963690e-04  8.295646e-04  8.639411e-04  8.995250e-04
## ASV0059     -2.759346e-03 -2.876146e-03 -2.997290e-03 -3.122894e-03
## ASV0013     -5.835833e-03 -6.088094e-03 -6.350253e-03 -6.622621e-03
## ASV0033     -1.798632e-03 -1.881352e-03 -1.967722e-03 -2.057885e-03
## ASV4354     -7.155481e-04 -7.448836e-04 -7.752690e-04 -8.067332e-04
## ASV0022     -1.889120e-03 -1.975451e-03 -2.065539e-03 -2.159528e-03
## ASV0134     -5.089126e-04 -5.343700e-04 -5.611057e-04 -5.891818e-04
## ASV0415     -2.734709e-04 -2.794068e-04 -2.851215e-04 -2.905768e-04
## ASV10103    -1.301386e-03 -1.359733e-03 -1.420539e-03 -1.483896e-03
## ASV1613      1.991201e-03  2.073793e-03  2.159315e-03  2.247835e-03
## ASV0135      3.211778e-05  4.208218e-05  5.317616e-05  6.549686e-05
## ASV0469     -2.472397e-03 -2.574602e-03 -2.680454e-03 -2.790042e-03
## ASV0471      1.649220e-03  1.722023e-03  1.797805e-03  1.876669e-03
## ASV0451     -5.126911e-04 -5.389718e-04 -5.666271e-04 -5.957273e-04
## ASV0747      7.099621e-04  7.452243e-04  7.822351e-04  8.210762e-04
## ASV1314     -1.072703e-03 -1.125719e-03 -1.181410e-03 -1.239913e-03
## ASV0425     -2.727322e-03 -2.835030e-03 -2.946127e-03 -3.060655e-03
## ASV0559     -1.555172e-03 -1.617360e-03 -1.681640e-03 -1.748062e-03
## ASV0148     -1.660877e-03 -1.724946e-03 -1.790871e-03 -1.858659e-03
## ASV0129     -7.404355e-04 -7.635098e-04 -7.867289e-04 -8.100353e-04
## ASV1072      7.920642e-04  8.216680e-04  8.520372e-04  8.831633e-04
## ASV2390      5.642068e-04  5.851703e-04  6.066542e-04  6.286490e-04
## ASV0548      1.916907e-03  2.002603e-03  2.091899e-03  2.184927e-03
## ASV0168     -2.752860e-03 -2.868245e-03 -2.987879e-03 -3.111876e-03
## ASV0066     -2.064672e-03 -2.152393e-03 -2.243409e-03 -2.337812e-03
## ASV0468     -7.787182e-04 -8.128839e-04 -8.484418e-04 -8.854417e-04
## ASV0172     -2.948504e-04 -2.991152e-04 -3.028410e-04 -3.059552e-04
## ASV0236     -8.908889e-04 -9.179087e-04 -9.450387e-04 -9.722088e-04
## ASV0250      2.852033e-04  3.113638e-04  3.397303e-04  3.704696e-04
## ASV0338     -3.685300e-05 -3.197629e-05 -2.642186e-05 -2.013659e-05
## ASV0450     -7.447889e-06 -7.639840e-06 -7.832688e-06 -8.026993e-06
## ASV0377      2.304437e-03  2.404680e-03  2.508905e-03  2.617240e-03
## ASV1022      6.547964e-04  6.842148e-04  7.148986e-04  7.468991e-04
## ASV6174     -1.490009e-04 -1.551002e-04 -1.614298e-04 -1.679986e-04
## ASV0786      2.251359e-04  2.331137e-04  2.412712e-04  2.496051e-04
## ASV0053     -2.789150e-03 -2.911420e-03 -3.038621e-03 -3.170918e-03
## ASV0697     -7.248188e-04 -7.518648e-04 -7.796292e-04 -8.081093e-04
## ASV0785      2.069580e-03  2.159920e-03  2.253875e-03  2.351567e-03
## ASV1967     -1.276397e-03 -1.327181e-03 -1.379634e-03 -1.433787e-03
## ASV0385     -5.644598e-04 -5.848658e-04 -6.057558e-04 -6.271223e-04
## ASV0295      1.286119e-04  1.416722e-04  1.558955e-04  1.713735e-04
## ASV0072     -2.081840e-03 -2.164445e-03 -2.249651e-03 -2.337485e-03
## ASV0157     -8.029545e-04 -8.306804e-04 -8.588661e-04 -8.874699e-04
## ASV0501      1.099784e-03  1.153075e-03  1.208942e-03  1.267505e-03
## ASV10729    -1.725314e-03 -1.802433e-03 -1.882780e-03 -1.966471e-03
## ASV1470      7.662041e-04  7.972917e-04  8.294221e-04  8.626132e-04
## ASV0050     -5.441088e-03 -5.672048e-03 -5.911700e-03 -6.160289e-03
## ASV0411     -8.630777e-05 -8.663999e-05 -8.669700e-05 -8.644704e-05
## ASV0549      1.132612e-03  1.186891e-03  1.243760e-03  1.303341e-03
## ASV0184      6.491427e-04  6.777909e-04  7.076400e-04  7.387374e-04
## ASV0705      8.149919e-04  8.523655e-04  8.913553e-04  9.320202e-04
## ASV1715      1.990981e-03  2.079213e-03  2.171095e-03  2.266760e-03
## ASV0603      2.563140e-04  2.690021e-04  2.823484e-04  2.963903e-04
## ASV0826      6.118930e-04  6.357863e-04  6.604067e-04  6.857610e-04
## ASV0034     -2.407444e-03 -2.506312e-03 -2.608594e-03 -2.714358e-03
## ASV0838      5.105618e-04  5.315015e-04  5.531372e-04  5.754766e-04
## ASV0614     -1.383999e-03 -1.441974e-03 -1.502067e-03 -1.564332e-03
## ASV0014     -5.288330e-03 -5.513736e-03 -5.747716e-03 -5.990518e-03
## ASV0585     -3.494216e-04 -3.652713e-04 -3.817956e-04 -3.990186e-04
## ASV0016     -5.412681e-03 -5.643777e-03 -5.883698e-03 -6.132700e-03
## ASV5394     -1.414497e-03 -1.477291e-03 -1.542673e-03 -1.610732e-03
## ASV0666      1.163069e-03  1.212432e-03  1.263647e-03  1.316766e-03
## ASV2085      3.307350e-04  3.374226e-04  3.437703e-04  3.497239e-04
## ASV0003     -4.923409e-03 -5.132008e-03 -5.348439e-03 -5.572922e-03
## ASV0346      4.379279e-05  5.365586e-05  6.454285e-05  7.653277e-05
## ASV0267     -7.045033e-04 -7.296978e-04 -7.554315e-04 -7.816856e-04
## ASV0353      1.216388e-03  1.277975e-03  1.342737e-03  1.410834e-03
## ASV2419      1.375351e-03  1.432847e-03  1.492450e-03  1.554217e-03
## ASV0447      8.265154e-04  8.712665e-04  9.184932e-04  9.683261e-04
## ASV0654      2.258882e-03  2.360649e-03  2.466711e-03  2.577219e-03
## ASV0151      4.467725e-04  4.727261e-04  5.002880e-04  5.295600e-04
## ASV0065     -2.000155e-03 -2.085498e-03 -2.174076e-03 -2.265980e-03
## ASV0527      1.454909e-03  1.517531e-03  1.582585e-03  1.650145e-03
## ASV4055     -5.986690e-04 -6.278649e-04 -6.585099e-04 -6.906779e-04
## ASV0166     -1.592954e-03 -1.656792e-03 -1.722729e-03 -1.790800e-03
## ASV0417     -1.385730e-03 -1.443786e-03 -1.503981e-03 -1.566375e-03
## ASV0078     -1.069678e-03 -1.111580e-03 -1.154728e-03 -1.199125e-03
## ASV0322     -1.303120e-03 -1.354430e-03 -1.407312e-03 -1.461780e-03
## ASV0156     -1.743626e-03 -1.815970e-03 -1.890922e-03 -1.968551e-03
## ASV0648     -1.688837e-03 -1.765656e-03 -1.845808e-03 -1.929422e-03
## ASV0407      1.675073e-04  1.773071e-04  1.877116e-04  1.987579e-04
## ASV2030     -3.008193e-04 -3.116182e-04 -3.227132e-04 -3.341105e-04
## ASV0300      1.071377e-03  1.124664e-03  1.180612e-03  1.239349e-03
## ASV1150     -8.063309e-05 -8.153091e-05 -8.223788e-05 -8.272889e-05
## ASV0958      1.122088e-03  1.178538e-03  1.237912e-03  1.300367e-03
## ASV0216     -1.611338e-03 -1.675619e-03 -1.742033e-03 -1.810622e-03
## ASV0446      2.553727e-03  2.674140e-03  2.800082e-03  2.931786e-03
## ASV0367     -8.090752e-04 -8.437299e-04 -8.797247e-04 -9.171013e-04
## ASV0200     -1.536031e-03 -1.603563e-03 -1.673858e-03 -1.747016e-03
## ASV0334     -6.181501e-04 -6.353852e-04 -6.525502e-04 -6.695901e-04
## ASV1311      1.046948e-03  1.090665e-03  1.135960e-03  1.182872e-03
## ASV0458      1.149643e-03  1.199079e-03  1.250457e-03  1.303843e-03
## ASV1371      4.217046e-05  4.440643e-05  4.676357e-05  4.924805e-05
## ASV0418      1.428602e-03  1.491372e-03  1.556711e-03  1.624711e-03
## ASV0004      1.679282e-03  1.751879e-03  1.827326e-03  1.905712e-03
## ASV1943      1.188767e-03  1.238303e-03  1.289667e-03  1.342908e-03
## ASV1495     -3.998047e-04 -4.229636e-04 -4.475357e-04 -4.736074e-04
## ASV0901     -2.012844e-03 -2.105957e-03 -2.203260e-03 -2.304930e-03
## ASV0628      1.069142e-03  1.112300e-03  1.156872e-03  1.202878e-03
## ASV0400      4.294855e-04  4.468472e-04  4.647748e-04  4.832749e-04
## ASV0116     -1.592435e-03 -1.668385e-03 -1.747923e-03 -1.831213e-03
## ASV0788      1.232704e-03  1.287084e-03  1.343688e-03  1.402593e-03
## ASV0117      8.731581e-04  9.164150e-04  9.618464e-04  1.009561e-03
## ASV3137      2.054193e-04  2.138368e-04  2.225495e-04  2.315643e-04
## ASV0001      1.898358e-03  1.973638e-03  2.051311e-03  2.131410e-03
## ASV1651      1.269061e-03  1.319811e-03  1.372243e-03  1.426390e-03
## ASV1692      1.545724e-03  1.619080e-03  1.695864e-03  1.776230e-03
## ASV0660      7.282775e-04  7.538959e-04  7.799939e-04  8.065399e-04
## ASV0508      6.737972e-05  6.855435e-05  6.965679e-05  7.067846e-05
## ASV1660     -6.555976e-04 -6.876121e-04 -7.211657e-04 -7.563264e-04
## ASV0233      3.715998e-04  3.904056e-04  4.101998e-04  4.310364e-04
## ASV1343     -1.488445e-03 -1.555460e-03 -1.625340e-03 -1.698196e-03
## ASV0209      1.244741e-03  1.293353e-03  1.343466e-03  1.395097e-03
## ASV0193     -1.668353e-03 -1.736449e-03 -1.806903e-03 -1.879766e-03
## ASV0357     -8.148221e-06 -2.754399e-06  3.365886e-06  1.028122e-05
## ASV0198      3.874456e-04  4.051572e-04  4.236559e-04  4.429757e-04
## ASV0007      1.799551e-03  1.870920e-03  1.944559e-03  2.020499e-03
## ASV1772     -1.852419e-04 -1.924512e-04 -1.998503e-04 -2.074338e-04
## ASV0009      1.689658e-03  1.756193e-03  1.824804e-03  1.895513e-03
## ASV0006      5.980349e-04  6.165719e-04  6.352351e-04  6.539822e-04
## ASV0011     -2.101487e-03 -2.197243e-03 -2.297173e-03 -2.401444e-03
## ASV0015      1.415296e-03  1.476604e-03  1.540319e-03  1.606513e-03
## ASV0017      1.492570e-03  1.556943e-03  1.623826e-03  1.693296e-03
## ASV0235     -1.220330e-03 -1.275376e-03 -1.332759e-03 -1.392563e-03
## ASV0382      3.361887e-04  3.575893e-04  3.803470e-04  4.045379e-04
## ASV2357      1.837117e-03  1.919326e-03  2.005016e-03  2.094321e-03
## ASV0567     -1.274114e-03 -1.328024e-03 -1.384001e-03 -1.442112e-03
## ASV0165      1.431255e-03  1.493572e-03  1.558374e-03  1.625740e-03
## ASV0005      2.802132e-03  2.919158e-03  3.040405e-03  3.165972e-03
## ASV0384     -5.286802e-05 -5.004165e-05 -4.663930e-05 -4.260049e-05
## ASV0002      6.832168e-04  7.169107e-04  7.522928e-04  7.894480e-04
## ASV3017      1.605538e-03  1.671075e-03  1.738870e-03  1.808971e-03
## ASV0091      6.832478e-04  7.150876e-04  7.483644e-04  7.831376e-04
## ASV0186     -1.769331e-03 -1.848166e-03 -1.930267e-03 -2.015746e-03
## ASV0370      1.980835e-04  2.079936e-04  2.184140e-04  2.293722e-04
## ASV0018      2.934889e-03  3.058463e-03  3.186585e-03  3.319372e-03
## ASV1377      2.549654e-03  2.656527e-03  2.767328e-03  2.882161e-03
## ASV0019      2.940551e-03  3.064485e-03  3.192994e-03  3.326194e-03
## ASV0023      7.949895e-05  7.561715e-05  7.098665e-05  6.553857e-05
## ASV2194      1.034444e-03  1.082783e-03  1.133342e-03  1.186218e-03
## ASV1155     -4.665727e-05 -4.481175e-05 -4.256028e-05 -3.986354e-05
## ASV0510     -9.549429e-04 -9.880516e-04 -1.021807e-03 -1.056184e-03
## ASV2371     -9.907740e-04 -1.029000e-03 -1.068388e-03 -1.108952e-03
## ASV0024     -6.596901e-05 -7.624655e-05 -8.753268e-05 -9.990522e-05
## ASV2452      1.317545e-03  1.369157e-03  1.422328e-03  1.477070e-03
## ASV2332      1.914409e-04  2.061032e-04  2.218243e-04  2.386711e-04
## ASV2591      1.835229e-04  1.976462e-04  2.127771e-04  2.289764e-04
## ASV0521      2.040637e-03  2.136006e-03  2.235728e-03  2.339992e-03
## ASV5542      6.567392e-04  6.883310e-04  7.213933e-04  7.559877e-04
## ASV0336     -8.956942e-04 -9.341763e-04 -9.741542e-04 -1.015675e-03
## ASV10102     1.385880e-03  1.448710e-03  1.514227e-03  1.582532e-03
## ASV16823    -9.445968e-04 -9.802774e-04 -1.016991e-03 -1.054747e-03
## ASV3104      9.442676e-04  9.799236e-04  1.016611e-03  1.054339e-03
## ASV0781      4.908670e-04  5.111815e-04  5.322131e-04  5.539783e-04
## ASV10899     6.070116e-04  6.398782e-04  6.745671e-04  7.111762e-04
## ASV11222    -9.441115e-04 -9.797597e-04 -1.016439e-03 -1.054160e-03
## ASV11327    -9.437826e-04 -9.794062e-04 -1.016060e-03 -1.053753e-03
## ASV12458    -9.434539e-04 -9.790529e-04 -1.015680e-03 -1.053345e-03
## ASV1636     -7.621444e-04 -7.902054e-04 -8.190060e-04 -8.485461e-04
## ASV1890     -9.655652e-04 -1.003661e-03 -1.043021e-03 -1.083674e-03
## ASV2898      2.191291e-03  2.282415e-03  2.376815e-03  2.474570e-03
## ASV8328     -3.613540e-05 -3.021883e-05 -2.348341e-05 -1.586009e-05
## ASV0709     -1.804491e-03 -1.880097e-03 -1.958452e-03 -2.039625e-03
## ASV0856      3.468428e-04  3.647110e-04  3.835101e-04  4.032867e-04
## ASV0909     -6.124936e-04 -6.297228e-04 -6.468863e-04 -6.639273e-04
## ASV0937     -1.478297e-03 -1.545027e-03 -1.614666e-03 -1.687338e-03
## ASV11390    -9.427929e-04 -9.783445e-04 -1.014922e-03 -1.052534e-03
## ASV11966     6.186012e-04  6.498165e-04  6.826017e-04  7.170307e-04
## ASV12990     2.957106e-04  3.088135e-04  3.224314e-04  3.365787e-04
## ASV14797     1.020788e-03  1.061383e-03  1.103281e-03  1.146503e-03
## ASV14904    -9.427689e-04 -9.783224e-04 -1.014902e-03 -1.052517e-03
## ASV15304     3.787306e-04  4.001221e-04  4.227336e-04  4.466296e-04
## ASV16696    -9.425523e-04 -9.780929e-04 -1.014659e-03 -1.052261e-03
## ASV1690      6.510345e-04  6.846416e-04  7.199593e-04  7.570653e-04
## ASV2029      2.857225e-03  2.978764e-03  3.104921e-03  3.235833e-03
## ASV2834      1.579057e-03  1.649095e-03  1.722046e-03  1.798015e-03
## ASV4003      5.853910e-04  6.183980e-04  6.533266e-04  6.902869e-04
## ASV4064      1.140935e-03  1.193136e-03  1.247595e-03  1.304399e-03
## ASV4294      4.822972e-04  5.090292e-04  5.372912e-04  5.671694e-04
## ASV4609     -1.280582e-05 -1.188849e-05 -1.083099e-05 -9.621822e-06
## ASV6283     -9.427481e-04 -9.783182e-04 -1.014918e-03 -1.052557e-03
## ASV6491     -9.424200e-04 -9.779655e-04 -1.014539e-03 -1.052150e-03
## ASV7453      5.256767e-04  5.543451e-04  5.846015e-04  6.165291e-04
## ASV7959      1.888979e-04  2.026460e-04  2.173607e-04  2.331026e-04
## ASV8219      9.423067e-04  9.778508e-04  1.014424e-03  1.052036e-03
## ASV8547     -9.419787e-04 -9.774983e-04 -1.014045e-03 -1.051629e-03
## ASV9319      7.591335e-04  7.946825e-04  8.318466e-04  8.706947e-04
## ASV9382     -9.418268e-04 -9.773380e-04 -1.013876e-03 -1.051452e-03
## ASV11516    -9.414992e-04 -9.769858e-04 -1.013498e-03 -1.051045e-03
## ASV14377    -9.411718e-04 -9.766339e-04 -1.013120e-03 -1.050640e-03
## ASV1867      1.597661e-03  1.670200e-03  1.745860e-03  1.824760e-03
## ASV1895     -3.119293e-04 -3.232673e-04 -3.349137e-04 -3.468726e-04
## ASV3168      6.194673e-04  6.439114e-04  6.690823e-04  6.949813e-04
## ASV4449      1.223030e-03  1.272117e-03  1.322888e-03  1.375382e-03
## ASV6596      8.737441e-04  9.185287e-04  9.656586e-04  1.015256e-03
## ASV7492     -2.622788e-04 -2.670314e-04 -2.714776e-04 -2.755745e-04
## ASV9854     -4.649181e-04 -4.814873e-04 -4.984700e-04 -5.158663e-04
## ASV6296      9.405988e-04  9.760246e-04  1.012473e-03  1.049953e-03
## ASV4201      5.042645e-04  5.346960e-04  5.670091e-04  6.013152e-04
## ASV0552      2.687448e-03  2.810368e-03  2.938655e-03  3.072520e-03
## ASV3671     -1.236721e-04 -1.245594e-04 -1.251769e-04 -1.254992e-04
## ASV3529     -1.075889e-04 -1.061679e-04 -1.042617e-04 -1.018294e-04
## ASV1060      6.889340e-04  7.214002e-04  7.553980e-04  7.910009e-04
## ASV0239     -1.326947e-03 -1.376955e-03 -1.428335e-03 -1.481085e-03
## ASV5711     -1.257124e-03 -1.307279e-03 -1.359120e-03 -1.412684e-03
## ASV4152     -1.733729e-03 -1.806768e-03 -1.882555e-03 -1.961174e-03
## ASV1461      1.458707e-03  1.514843e-03  1.572621e-03  1.632052e-03
## ASV2877      1.262196e-03  1.314891e-03  1.369476e-03  1.425995e-03
## ASV0012      1.057608e-03  1.108403e-03  1.161622e-03  1.217379e-03
## ASV9823      3.019371e-04  3.121636e-04  3.225479e-04  3.330750e-04
## ASV0008      1.137600e-03  1.191365e-03  1.247637e-03  1.306530e-03
## ASV7832     -1.047682e-03 -1.090994e-03 -1.135895e-03 -1.182431e-03
## ASV1915      1.383543e-04  1.468035e-04  1.557412e-04  1.651897e-04
## ASV0055      7.487584e-04  7.808220e-04  8.141050e-04  8.486412e-04
## ASV0032      1.741648e-03  1.812699e-03  1.886203e-03  1.962213e-03
## ASV2977     -1.457515e-03 -1.518742e-03 -1.582256e-03 -1.648123e-03
## ASV0466      1.416122e-03  1.472005e-03  1.529662e-03  1.589117e-03
## ASV3866      1.652306e-03  1.726920e-03  1.804735e-03  1.885877e-03
## ASV0040      2.241445e-03  2.345133e-03  2.453464e-03  2.566632e-03
## ASV0496     -2.280594e-04 -2.442974e-04 -2.616964e-04 -2.803336e-04
## ASV0052      2.544959e-03  2.652599e-03  2.764248e-03  2.880014e-03
## ASV3828     -1.543407e-03 -1.608144e-03 -1.675331e-03 -1.745048e-03
## ASV1930      1.000929e-03  1.044227e-03  1.089181e-03  1.135837e-03
## ASV2126      1.603404e-03  1.671965e-03  1.743143e-03  1.817013e-03
## ASV0793      1.099612e-03  1.154323e-03  1.211761e-03  1.272056e-03
## ASV0299     -5.673368e-04 -5.862275e-04 -6.054554e-04 -6.250076e-04
## ASV0208      1.622191e-03  1.699143e-03  1.779709e-03  1.864053e-03
## ASV0511     -6.743305e-04 -6.952976e-04 -7.164241e-04 -7.376665e-04
## ASV1123     -9.707593e-04 -1.006785e-03 -1.043764e-03 -1.081693e-03
## ASV0099     -5.605192e-04 -5.823526e-04 -6.047828e-04 -6.278000e-04
## ASV0752     -1.755012e-04 -1.857425e-04 -1.965718e-04 -2.080189e-04
## ASV0883      4.925336e-05  5.311372e-05  5.725411e-05  6.169189e-05
## ASV0683      1.438801e-03  1.506266e-03  1.576810e-03  1.650567e-03
## ASV4117     -1.560180e-03 -1.625915e-03 -1.694151e-03 -1.764969e-03
## ASV2172      6.097086e-04  6.366557e-04  6.647080e-04  6.939045e-04
## ASV0330     -1.111596e-03 -1.160958e-03 -1.212354e-03 -1.265856e-03
## ASV0728      1.111474e-03  1.163660e-03  1.218202e-03  1.275194e-03
## ASV0499      2.175970e-03  2.278665e-03  2.386144e-03  2.498621e-03
## ASV0120     -2.258371e-03 -2.355845e-03 -2.457091e-03 -2.562219e-03
## ASV1446      1.013929e-04  1.010592e-04  1.003280e-04  9.915597e-05
## ASV17171    -1.494599e-03 -1.558316e-03 -1.624522e-03 -1.693303e-03
## ASV0533      4.773385e-04  5.006985e-04  5.252126e-04  5.509371e-04
## ASV2495     -6.579360e-04 -6.892904e-04 -7.221706e-04 -7.566534e-04
## ASV5582      4.642171e-04  4.801782e-04  4.964370e-04  5.129792e-04
## ASV1488      5.308312e-04  5.560045e-04  5.823354e-04  6.098718e-04
## ASV0682      1.511919e-03  1.583019e-03  1.657401e-03  1.735207e-03
## ASV0068     -1.714347e-04 -1.835567e-04 -1.965193e-04 -2.103742e-04
## ASV1987     -8.806725e-04 -9.251498e-04 -9.718957e-04 -1.021023e-03
## ASV0035      1.174685e-04  1.135059e-04  1.085730e-04  1.025658e-04
## ASV7192     -9.450800e-04 -9.816930e-04 -1.019416e-03 -1.058261e-03
## ASV0873      7.935283e-05  7.917676e-05  7.874223e-05  7.802658e-05
## ASV4749     -5.252631e-05 -6.277826e-05 -7.410300e-05 -8.658802e-05
## ASV2174      8.762629e-04  9.089249e-04  9.424799e-04  9.769317e-04
## ASV1476     -8.669745e-04 -9.061440e-04 -9.470393e-04 -9.897348e-04
## ASV0740     -2.185197e-03 -2.287055e-03 -2.393534e-03 -2.504832e-03
## ASV0170      4.433294e-04  4.629421e-04  4.833748e-04  5.046589e-04
## ASV2466     -1.876289e-03 -1.958422e-03 -2.043930e-03 -2.132938e-03
## ASV1709      1.424285e-03  1.484617e-03  1.547243e-03  1.612230e-03
## ASV6170     -1.379839e-03 -1.442114e-03 -1.507053e-03 -1.574756e-03
## ASV3673      1.583880e-03  1.655620e-03  1.730450e-03  1.808489e-03
## ASV1745      1.238402e-04  1.294970e-04  1.353931e-04  1.415366e-04
##                                                                    
## (Intercept) -2.492627e-04 -2.791062e-04 -3.122088e-04 -3.488785e-04
## ASV1236      1.219075e-03  1.266795e-03  1.316015e-03  1.366759e-03
## ASV0421     -2.198266e-03 -2.285745e-03 -2.376062e-03 -2.469266e-03
## ASV0691     -1.796660e-03 -1.862242e-03 -1.929532e-03 -1.998533e-03
## ASV0899      4.530504e-05  5.048731e-05  5.604498e-05  6.199257e-05
## ASV1004      2.501209e-03  2.600704e-03  2.703404e-03  2.809358e-03
## ASV1041     -1.693347e-03 -1.760405e-03 -1.829563e-03 -1.900844e-03
## ASV1058      2.332108e-03  2.425612e-03  2.522227e-03  2.622015e-03
## ASV12542     6.593365e-04  6.828474e-04  7.069251e-04  7.315666e-04
## ASV1294      2.768398e-03  2.882358e-03  3.000336e-03  3.122426e-03
## ASV13113     1.118595e-03  1.171931e-03  1.227797e-03  1.286310e-03
## ASV1318      2.366667e-03  2.461467e-03  2.559390e-03  2.660492e-03
## ASV2269     -7.066272e-04 -7.348532e-04 -7.639869e-04 -7.940411e-04
## ASV2542      1.688266e-03  1.765494e-03  1.846110e-03  1.930251e-03
## ASV2660     -1.324066e-03 -1.374886e-03 -1.427203e-03 -1.481030e-03
## ASV2737     -1.093219e-04 -1.155088e-04 -1.220179e-04 -1.288612e-04
## ASV2840      1.736040e-03  1.801083e-03  1.867888e-03  1.936455e-03
## ASV3053      8.452379e-05  8.736514e-05  9.027779e-05  9.326391e-05
## ASV3077      5.523074e-04  5.739248e-04  5.962352e-04  6.192521e-04
## ASV3134      2.224773e-03  2.329377e-03  2.438830e-03  2.553350e-03
## ASV3140      9.432852e-04  9.854311e-04  1.029316e-03  1.074998e-03
## ASV3579      4.697782e-04  4.957887e-04  5.232961e-04  5.523847e-04
## ASV6119     -7.060551e-04 -7.342395e-04 -7.633295e-04 -7.933377e-04
## ASV7557     -7.057297e-04 -7.338876e-04 -7.629490e-04 -7.929267e-04
## ASV8422      3.638697e-04  3.772298e-04  3.909613e-04  4.050686e-04
## ASV1086     -1.813458e-04 -1.879833e-04 -1.948100e-04 -2.018294e-04
## ASV1310      1.373646e-03  1.430176e-03  1.488669e-03  1.549166e-03
## ASV15750    -3.190476e-04 -3.308232e-04 -3.428870e-04 -3.552342e-04
## ASV16905    -7.056020e-04 -7.337501e-04 -7.628011e-04 -7.927678e-04
## ASV2033      1.494523e-03  1.563789e-03  1.636140e-03  1.711697e-03
## ASV2089      4.877520e-04  5.073900e-04  5.276663e-04  5.485897e-04
## ASV2127      1.945848e-03  2.024811e-03  2.106473e-03  2.190892e-03
## ASV2725      2.110677e-03  2.191357e-03  2.274390e-03  2.359795e-03
## ASV2804     -7.055836e-04 -7.337343e-04 -7.627889e-04 -7.927599e-04
## ASV3075      1.438923e-03  1.500293e-03  1.564080e-03  1.630373e-03
## ASV3327      1.439594e-03  1.505471e-03  1.574238e-03  1.646010e-03
## ASV3342      1.522062e-03  1.589181e-03  1.659039e-03  1.731732e-03
## ASV3532     -1.370499e-03 -1.430973e-03 -1.493942e-03 -1.559499e-03
## ASV3600      1.724388e-03  1.799819e-03  1.878303e-03  1.959947e-03
## ASV4013      1.383881e-03  1.440741e-03  1.499594e-03  1.560486e-03
## ASV4136      1.325073e-03  1.377168e-03  1.430929e-03  1.486387e-03
## ASV4195      7.051553e-04  7.332732e-04  7.622929e-04  7.922268e-04
## ASV4407     -7.048306e-04 -7.329221e-04 -7.619134e-04 -7.918168e-04
## ASV4717      5.236172e-06  3.862406e-06  2.343827e-06  6.733300e-07
## ASV6794      6.807128e-04  7.059399e-04  7.318892e-04  7.585715e-04
## ASV8324     -7.046952e-04 -7.327739e-04 -7.617513e-04 -7.916398e-04
## ASV8981     -1.295864e-04 -1.312144e-04 -1.325705e-04 -1.336197e-04
## ASV9859      6.818354e-04  7.175797e-04  7.552810e-04  7.950488e-04
## ASV0936     -1.126316e-03 -1.172622e-03 -1.220561e-03 -1.270172e-03
## ASV12683    -1.427678e-04 -1.498451e-04 -1.572436e-04 -1.649735e-04
## ASV1293      1.620207e-03  1.684432e-03  1.750726e-03  1.819125e-03
## ASV13055    -1.497656e-04 -1.543777e-04 -1.590115e-04 -1.636552e-04
## ASV17063    -7.042979e-04 -7.323552e-04 -7.613110e-04 -7.911781e-04
## ASV2228      7.039740e-04  7.320048e-04  7.609323e-04  7.907690e-04
## ASV2769     -7.730917e-05 -7.746937e-05 -7.739287e-05 -7.705653e-05
## ASV2803      3.031474e-04  3.137625e-04  3.246284e-04  3.357445e-04
## ASV2896      9.569819e-04  1.000016e-03  1.044952e-03  1.091875e-03
## ASV3062      3.705888e-04  3.912107e-04  4.130236e-04  4.360943e-04
## ASV3107      1.144225e-03  1.194618e-03  1.247088e-03  1.301710e-03
## ASV3265      2.100178e-03  2.182991e-03  2.268428e-03  2.356528e-03
## ASV3666     -6.139718e-05 -6.463884e-05 -6.806245e-05 -7.167916e-05
## ASV4497      5.028523e-04  5.230485e-04  5.439201e-04  5.654803e-04
## ASV6914     -2.667768e-04 -2.784548e-04 -2.905922e-04 -3.032028e-04
## ASV0576     -2.378051e-03 -2.466854e-03 -2.558128e-03 -2.651890e-03
## ASV0673      7.574946e-04  7.932589e-04  8.306022e-04  8.695794e-04
## ASV0772      7.920380e-04  8.258287e-04  8.609339e-04  8.973968e-04
## ASV0862     -5.394788e-04 -5.572058e-04 -5.751930e-04 -5.934182e-04
## ASV0898      7.414680e-04  7.773382e-04  8.148934e-04  8.542037e-04
## ASV0910      1.552248e-03  1.625426e-03  1.701958e-03  1.781984e-03
## ASV0964     -8.741980e-04 -9.073113e-04 -9.413538e-04 -9.763281e-04
## ASV10059     7.432875e-04  7.794416e-04  8.173609e-04  8.571295e-04
## ASV10263    -7.059192e-04 -7.341229e-04 -7.632382e-04 -7.932789e-04
## ASV1088      8.394018e-04  8.801824e-04  9.229717e-04  9.678692e-04
## ASV1101      1.260042e-03  1.311986e-03  1.365709e-03  1.421239e-03
## ASV1183      8.326420e-04  8.686546e-04  9.060732e-04  9.449414e-04
## ASV11956     2.607635e-04  2.690677e-04  2.775025e-04  2.860623e-04
## ASV12774    -1.320442e-04 -1.386603e-04 -1.455981e-04 -1.528717e-04
## ASV1321      4.369716e-04  4.615710e-04  4.875921e-04  5.151130e-04
## ASV13793    -7.055319e-04 -7.337037e-04 -7.627849e-04 -7.927889e-04
## ASV14482    -9.124599e-05 -9.605948e-05 -1.010975e-04 -1.063662e-04
## ASV15483     5.441333e-04  5.686957e-04  5.943110e-04  6.210190e-04
## ASV2062      3.234595e-03  3.370918e-03  3.512314e-03  3.658923e-03
## ASV2132      1.554322e-03  1.624420e-03  1.697515e-03  1.773721e-03
## ASV2413      2.021214e-03  2.102970e-03  2.187528e-03  2.274949e-03
## ASV2490      1.278713e-03  1.327507e-03  1.377721e-03  1.429367e-03
## ASV2594      7.709378e-04  8.049011e-04  8.403181e-04  8.772519e-04
## ASV2822     -7.061949e-04 -7.344304e-04 -7.635814e-04 -7.936620e-04
## ASV2863      1.212586e-03  1.260379e-03  1.309705e-03  1.360590e-03
## ASV2910      1.572970e-03  1.634521e-03  1.698003e-03  1.763447e-03
## ASV2980      5.700273e-04  5.920900e-04  6.148019e-04  6.381668e-04
## ASV3307      7.056573e-04  7.338492e-04  7.629534e-04  7.929839e-04
## ASV3474      1.275318e-03  1.335935e-03  1.399364e-03  1.465725e-03
## ASV3502      2.410177e-03  2.513113e-03  2.620014e-03  2.731006e-03
## ASV4236      1.125362e-03  1.168245e-03  1.212363e-03  1.257725e-03
## ASV4842     -3.950856e-04 -4.112170e-04 -4.278810e-04 -4.450847e-04
## ASV4894     -7.061361e-04 -7.343741e-04 -7.635287e-04 -7.936144e-04
## ASV5290      9.104129e-04  9.490687e-04  9.891646e-04  1.030737e-03
## ASV5501      1.712350e-04  1.788271e-04  1.867577e-04  1.950432e-04
## ASV5795      6.546048e-04  6.847478e-04  7.162212e-04  7.490772e-04
## ASV5987     -7.063410e-04 -7.346007e-04 -7.637792e-04 -7.938914e-04
## ASV6267     -7.060149e-04 -7.342478e-04 -7.633976e-04 -7.934789e-04
## ASV6862      1.285202e-03  1.333021e-03  1.382167e-03  1.432651e-03
## ASV7145      2.260515e-04  2.342459e-04  2.426846e-04  2.513751e-04
## ASV7673     -7.058994e-04 -7.341220e-04 -7.632607e-04 -7.933299e-04
## ASV7789      3.648785e-04  3.858473e-04  4.080775e-04  4.316438e-04
## ASV7809     -3.414289e-05 -3.249544e-05 -3.053587e-05 -2.823702e-05
## ASV8002     -7.057888e-04 -7.340107e-04 -7.631498e-04 -7.932208e-04
## ASV8205      4.370417e-04  4.563153e-04  4.764032e-04  4.973380e-04
## ASV9155     -5.240756e-04 -5.445806e-04 -5.657115e-04 -5.874746e-04
## ASV9221     -1.714097e-05 -1.407904e-05 -1.057872e-05 -6.601416e-06
## ASV9311     -7.054370e-04 -7.336359e-04 -7.627510e-04 -7.927971e-04
## ASV9557     -7.051116e-04 -7.332838e-04 -7.623702e-04 -7.923856e-04
## ASV9936     -7.047865e-04 -7.329320e-04 -7.619899e-04 -7.919745e-04
## ASV1445      1.769409e-03  1.848361e-03  1.930628e-03  2.016334e-03
## ASV4232      1.567764e-03  1.642050e-03  1.719854e-03  1.801341e-03
## ASV6479      9.839438e-05  1.083097e-04  1.190763e-04  1.307565e-04
## ASV0142     -3.487936e-03 -3.623625e-03 -3.763500e-03 -3.907616e-03
## ASV0378     -1.088328e-03 -1.127121e-03 -1.166759e-03 -1.207217e-03
## ASV1122      2.339408e-03  2.443569e-03  2.552057e-03  2.665024e-03
## ASV0123     -3.409698e-03 -3.541931e-03 -3.678206e-03 -3.818576e-03
## ASV2064      3.128784e-04  3.228446e-04  3.329402e-04  3.431526e-04
## ASV4459     -3.782905e-04 -3.929694e-04 -4.080958e-04 -4.236760e-04
## ASV0448      7.932197e-04  8.349944e-04  8.790027e-04  9.253591e-04
## ASV0397      1.711495e-03  1.785762e-03  1.862963e-03  1.943193e-03
## ASV0485      2.332210e-03  2.430560e-03  2.532627e-03  2.638524e-03
## ASV1566      1.995110e-03  2.081033e-03  2.170286e-03  2.262971e-03
## ASV1365      1.303993e-03  1.360766e-03  1.419785e-03  1.481119e-03
## ASV1065      2.661074e-03  2.776638e-03  2.896792e-03  3.021687e-03
## ASV0722     -3.432755e-05 -3.494383e-05 -3.553984e-05 -3.611463e-05
## ASV12660    -1.136634e-03 -1.180326e-03 -1.225335e-03 -1.271678e-03
## ASV0223     -3.443852e-05 -3.492356e-05 -3.532413e-05 -3.562670e-05
## ASV0229      1.237445e-03  1.293876e-03  1.352778e-03  1.414252e-03
## ASV0877     -3.756264e-04 -3.879648e-04 -4.005091e-04 -4.132503e-04
## ASV0983      2.340203e-03  2.436318e-03  2.535820e-03  2.638792e-03
## ASV0626     -6.238691e-04 -6.418917e-04 -6.599692e-04 -6.780635e-04
## ASV4146     -1.182977e-04 -1.227153e-04 -1.272733e-04 -1.319778e-04
## ASV4175     -1.487251e-03 -1.551053e-03 -1.617309e-03 -1.686093e-03
## ASV2082     -1.908379e-04 -2.039356e-04 -2.179780e-04 -2.330314e-04
## ASV2272      1.122126e-03  1.173209e-03  1.226528e-03  1.282176e-03
## ASV2245     -1.315951e-03 -1.373506e-03 -1.433369e-03 -1.495613e-03
## ASV0590     -9.205879e-04 -9.672764e-04 -1.016348e-03 -1.067918e-03
## ASV0217     -8.614942e-04 -8.808355e-04 -8.995686e-04 -9.175811e-04
## ASV0416      1.038053e-03  1.073909e-03  1.110491e-03  1.147776e-03
## ASV1056      1.573869e-03  1.648598e-03  1.726757e-03  1.808487e-03
## ASV7777     -1.291870e-03 -1.347932e-03 -1.406230e-03 -1.466841e-03
## ASV0455      2.978089e-04  3.123301e-04  3.275132e-04  3.433808e-04
## ASV0604      3.944883e-04  4.172545e-04  4.413384e-04  4.668092e-04
## ASV6100     -1.202790e-03 -1.255556e-03 -1.310477e-03 -1.367632e-03
## ASV11359    -1.308972e-03 -1.364145e-03 -1.421360e-03 -1.480671e-03
## ASV6604      9.973304e-04  1.043326e-03  1.091373e-03  1.141557e-03
## ASV5004     -7.656049e-04 -7.978425e-04 -8.312866e-04 -8.659732e-04
## ASV1483     -7.165117e-04 -7.471994e-04 -7.790727e-04 -8.121688e-04
## ASV9773     -1.531332e-03 -1.597925e-03 -1.667180e-03 -1.739190e-03
## ASV4059      2.171914e-04  2.304575e-04  2.445576e-04  2.595414e-04
## ASV1193      2.470309e-03  2.576333e-03  2.686458e-03  2.800809e-03
## ASV4610     -9.086416e-05 -8.869181e-05 -8.601519e-05 -8.279548e-05
## ASV0742     -7.342359e-04 -7.559718e-04 -7.778132e-04 -7.997154e-04
## ASV1502     -7.495220e-05 -8.132489e-05 -8.818696e-05 -9.557010e-05
## ASV0195     -3.476162e-04 -3.662349e-04 -3.858388e-04 -4.064747e-04
## ASV1213      6.853056e-04  7.095446e-04  7.343119e-04  7.595941e-04
## ASV1648     -1.125050e-03 -1.173642e-03 -1.224166e-03 -1.276688e-03
## ASV6984     -8.586852e-04 -8.967071e-04 -9.363206e-04 -9.775878e-04
## ASV0396     -3.732192e-04 -3.758311e-04 -3.775334e-04 -3.782315e-04
## ASV4297      1.169023e-03  1.214150e-03  1.260648e-03  1.308535e-03
## ASV2622      2.728819e-03  2.837843e-03  2.950484e-03  3.066813e-03
## ASV3512      5.655666e-04  5.967811e-04  6.298056e-04  6.647465e-04
## ASV2411      1.077161e-03  1.127992e-03  1.181161e-03  1.236766e-03
## ASV2291     -3.283652e-04 -3.467190e-04 -3.661377e-04 -3.866811e-04
## ASV0807      1.347869e-03  1.415315e-03  1.486103e-03  1.560386e-03
## ASV1292      6.178252e-04  6.428079e-04  6.686648e-04  6.954195e-04
## ASV1035      2.569374e-04  2.658735e-04  2.750364e-04  2.844297e-04
## ASV0070     -5.182167e-04 -5.312393e-04 -5.439959e-04 -5.564176e-04
## ASV0255      2.741661e-04  2.852933e-04  2.967537e-04  3.085434e-04
## ASV0057     -2.678839e-03 -2.777783e-03 -2.879281e-03 -2.983316e-03
## ASV0077     -2.885360e-04 -2.930239e-04 -2.970537e-04 -3.005656e-04
## ASV0625      2.757561e-03  2.864950e-03  2.975641e-03  3.089673e-03
## ASV2464      1.295233e-03  1.343963e-03  1.394094e-03  1.445638e-03
## ASV1315      2.760860e-03  2.889035e-03  3.022959e-03  3.162868e-03
## ASV2673      2.047722e-03  2.145092e-03  2.247046e-03  2.353792e-03
## ASV2161      8.544254e-04  8.956238e-04  9.388053e-04  9.840630e-04
## ASV0337     -1.209377e-03 -1.259466e-03 -1.311332e-03 -1.365016e-03
## ASV7680     -1.483194e-03 -1.548247e-03 -1.615939e-03 -1.686361e-03
## ASV0611      3.330507e-03  3.482657e-03  3.641516e-03  3.807361e-03
## ASV3118     -1.118928e-03 -1.169128e-03 -1.221445e-03 -1.275957e-03
## ASV1284      1.178783e-03  1.231675e-03  1.286811e-03  1.344275e-03
## ASV0889      8.435197e-04  8.787990e-04  9.154037e-04  9.533755e-04
## ASV4649     -9.064301e-04 -9.453885e-04 -9.858610e-04 -1.027895e-03
## ASV1108     -1.274374e-03 -1.335517e-03 -1.399567e-03 -1.466657e-03
## ASV0738      8.966849e-05  1.077552e-04  1.276841e-04  1.495976e-04
## ASV0473      1.879866e-04  1.967815e-04  2.059946e-04  2.156465e-04
## ASV0598     -1.160852e-03 -1.202763e-03 -1.245691e-03 -1.289625e-03
## ASV0429      2.038030e-03  2.122139e-03  2.209212e-03  2.299319e-03
## ASV1549      2.298220e-03  2.408183e-03  2.523350e-03  2.643956e-03
## ASV1203      1.563803e-03  1.629755e-03  1.698159e-03  1.769082e-03
## ASV4532      3.899466e-05  3.946751e-05  3.991059e-05  4.032524e-05
## ASV0274     -1.421409e-03 -1.473694e-03 -1.527347e-03 -1.582364e-03
## ASV0163     -2.007741e-03 -2.080267e-03 -2.154565e-03 -2.230623e-03
## ASV1298      8.192718e-04  8.494055e-04  8.803645e-04  9.121570e-04
## ASV9424     -1.998510e-03 -2.087988e-03 -2.181255e-03 -2.278456e-03
## ASV0412      2.918525e-03  3.040841e-03  3.167685e-03  3.299183e-03
## ASV0284      1.209979e-03  1.255626e-03  1.302563e-03  1.350798e-03
## ASV0620     -1.098983e-03 -1.151537e-03 -1.206537e-03 -1.264087e-03
## ASV0153     -2.201369e-03 -2.302795e-03 -2.408695e-03 -2.519245e-03
## ASV0498      4.207462e-04  4.486498e-04  4.783499e-04  5.099452e-04
## ASV0097      1.609448e-03  1.685724e-03  1.765577e-03  1.849170e-03
## ASV0104     -6.804047e-03 -7.093361e-03 -7.393652e-03 -7.705241e-03
## ASV1282      1.227224e-03  1.281550e-03  1.338086e-03  1.396905e-03
## ASV3883     -7.519090e-04 -7.871650e-04 -8.239973e-04 -8.624662e-04
## ASV0801      7.883516e-04  8.272550e-04  8.680526e-04  9.108308e-04
## ASV1611     -2.726724e-03 -2.848653e-03 -2.975719e-03 -3.108112e-03
## ASV0227     -1.104094e-03 -1.159147e-03 -1.216927e-03 -1.277562e-03
## ASV0833      1.178409e-03  1.236604e-03  1.297620e-03  1.361582e-03
## ASV0718      2.486512e-03  2.594905e-03  2.707632e-03  2.824837e-03
## ASV1139      7.391864e-04  7.620322e-04  7.850311e-04  8.081312e-04
## ASV0766     -6.259634e-04 -6.503805e-04 -6.755491e-04 -7.014792e-04
## ASV2091      3.050546e-03  3.168590e-03  3.290220e-03  3.415479e-03
## ASV1238     -7.140707e-05 -6.716679e-05 -6.218899e-05 -5.641036e-05
## ASV9193     -4.123978e-04 -4.361632e-04 -4.613164e-04 -4.879328e-04
## ASV0290     -3.508702e-04 -3.694791e-04 -3.890294e-04 -4.095572e-04
## ASV0231      2.576270e-03  2.685384e-03  2.798621e-03  2.916100e-03
## ASV0185      8.837601e-04  9.447926e-04  1.010103e-03  1.079973e-03
## ASV2330      7.057213e-04  7.335614e-04  7.622957e-04  7.919402e-04
## ASV3119     -1.030574e-03 -1.084354e-03 -1.140994e-03 -1.200641e-03
## ASV2368     -1.284702e-03 -1.345470e-03 -1.409092e-03 -1.475702e-03
## ASV0122     -8.485353e-04 -8.804240e-04 -9.132109e-04 -9.469019e-04
## ASV1044      1.830148e-03  1.919543e-03  2.013280e-03  2.111557e-03
## ASV0160     -2.032616e-03 -2.105063e-03 -2.179168e-03 -2.254904e-03
## ASV0326      1.514208e-03  1.579986e-03  1.648353e-03  1.719388e-03
## ASV1388      2.608868e-03  2.720179e-03  2.835760e-03  2.955740e-03
## ASV0792      2.857372e-03  2.973663e-03  3.093928e-03  3.218248e-03
## ASV0036     -1.964294e-03 -2.053173e-03 -2.145828e-03 -2.242396e-03
## ASV2125      3.044992e-03  3.174507e-03  3.308931e-03  3.448407e-03
## ASV1075      6.415910e-04  6.722888e-04  7.044410e-04  7.381136e-04
## ASV0390      7.179437e-04  7.569960e-04  7.982752e-04  8.419103e-04
## ASV3790     -2.529199e-03 -2.641392e-03 -2.758229e-03 -2.879875e-03
## ASV1535     -2.611793e-04 -2.758413e-04 -2.913651e-04 -3.078007e-04
## ASV0263      5.169233e-04  5.395464e-04  5.630817e-04  5.875601e-04
## ASV0675      4.324688e-03  4.525783e-03  4.735942e-03  4.955545e-03
## ASV3348      4.582238e-04  4.818719e-04  5.067738e-04  5.329956e-04
## ASV0058     -3.796012e-03 -3.954797e-03 -4.119358e-03 -4.289839e-03
## ASV4142      9.363424e-04  9.744187e-04  1.013779e-03  1.054448e-03
## ASV0059     -3.253070e-03 -3.387931e-03 -3.527588e-03 -3.672151e-03
## ASV0013     -6.905517e-03 -7.199261e-03 -7.504180e-03 -7.820604e-03
## ASV0033     -2.151992e-03 -2.250196e-03 -2.352653e-03 -2.459525e-03
## ASV4354     -8.393057e-04 -8.730165e-04 -9.078961e-04 -9.439759e-04
## ASV0022     -2.257567e-03 -2.359808e-03 -2.466405e-03 -2.577518e-03
## ASV0134     -6.186628e-04 -6.496163e-04 -6.821124e-04 -7.162244e-04
## ASV0415     -2.957317e-04 -3.005432e-04 -3.049655e-04 -3.089504e-04
## ASV10103    -1.549895e-03 -1.618633e-03 -1.690207e-03 -1.764716e-03
## ASV1613      2.339414e-03  2.434116e-03  2.532001e-03  2.633127e-03
## ASV0135      7.914799e-05  9.424013e-05  1.108910e-04  1.292259e-04
## ASV0469     -2.903458e-03 -3.020791e-03 -3.142131e-03 -3.267568e-03
## ASV0471      1.958723e-03  2.044076e-03  2.132840e-03  2.225130e-03
## ASV0451     -6.263459e-04 -6.585592e-04 -6.924471e-04 -7.280924e-04
## ASV0747      8.618324e-04  9.045914e-04  9.494438e-04  9.964829e-04
## ASV1314     -1.301374e-03 -1.365943e-03 -1.433779e-03 -1.505051e-03
## ASV0425     -3.178653e-03 -3.300156e-03 -3.425195e-03 -3.553794e-03
## ASV0559     -1.816675e-03 -1.887528e-03 -1.960674e-03 -2.036164e-03
## ASV0148     -1.928310e-03 -1.999819e-03 -2.073178e-03 -2.148374e-03
## ASV0129     -8.333657e-04 -8.566503e-04 -8.798132e-04 -9.027715e-04
## ASV1072      9.150354e-04  9.476395e-04  9.809585e-04  1.014972e-03
## ASV2390      6.511428e-04  6.741212e-04  6.975674e-04  7.214615e-04
## ASV0548      2.281822e-03  2.382724e-03  2.487775e-03  2.597121e-03
## ASV0168     -3.240354e-03 -3.373428e-03 -3.511217e-03 -3.653839e-03
## ASV0066     -2.435692e-03 -2.537137e-03 -2.642237e-03 -2.751081e-03
## ASV0468     -9.239348e-04 -9.639738e-04 -1.005613e-03 -1.048909e-03
## ASV0172     -3.083795e-04 -3.100306e-04 -3.108192e-04 -3.106500e-04
## ASV0236     -9.993421e-04 -1.026355e-03 -1.053158e-03 -1.079653e-03
## ASV0250      4.037586e-04  4.397855e-04  4.787496e-04  5.208620e-04
## ASV0338     -1.306494e-05 -5.149017e-06  3.671361e-06  1.345861e-05
## ASV0450     -8.223591e-06 -8.423653e-06 -8.628757e-06 -8.840970e-06
## ASV0377      2.729815e-03  2.846761e-03  2.968213e-03  3.094305e-03
## ASV1022      7.802696e-04  8.150655e-04  8.513443e-04  8.891657e-04
## ASV6174     -1.748157e-04 -1.818911e-04 -1.892350e-04 -1.968583e-04
## ASV0786      2.581112e-04  2.667849e-04  2.756209e-04  2.846132e-04
## ASV0053     -3.308479e-03 -3.451476e-03 -3.600081e-03 -3.754472e-03
## ASV0697     -8.373005e-04 -8.671964e-04 -8.977884e-04 -9.290662e-04
## ASV0785      2.453117e-03  2.558649e-03  2.668290e-03  2.782169e-03
## ASV1967     -1.489672e-03 -1.547319e-03 -1.606755e-03 -1.668010e-03
## ASV0385     -6.489559e-04 -6.712458e-04 -6.939797e-04 -7.171433e-04
## ASV0295      1.882038e-04  2.064904e-04  2.263437e-04  2.478812e-04
## ASV0072     -2.427971e-03 -2.521129e-03 -2.616973e-03 -2.715513e-03
## ASV0157     -9.164442e-04 -9.457352e-04 -9.752824e-04 -1.005018e-03
## ASV0501      1.328889e-03  1.393222e-03  1.460640e-03  1.531280e-03
## ASV10729    -2.053626e-03 -2.144368e-03 -2.238820e-03 -2.337110e-03
## ASV1470      8.968817e-04  9.322434e-04  9.687128e-04  1.006303e-03
## ASV0050     -6.418058e-03 -6.685253e-03 -6.962118e-03 -7.248898e-03
## ASV0411     -8.585612e-05 -8.488800e-05 -8.350410e-05 -8.166348e-05
## ASV0549      1.365758e-03  1.431143e-03  1.499631e-03  1.571364e-03
## ASV0184      7.711326e-04  8.048769e-04  8.400238e-04  8.766291e-04
## ASV0705      9.744203e-04  1.018616e-03  1.064670e-03  1.112644e-03
## ASV1715      2.366342e-03  2.469978e-03  2.577810e-03  2.689982e-03
## ASV0603      3.111674e-04  3.267223e-04  3.431000e-04  3.603488e-04
## ASV0826      7.118548e-04  7.386927e-04  7.662780e-04  7.946127e-04
## ASV0034     -2.823667e-03 -2.936584e-03 -3.053166e-03 -3.173469e-03
## ASV0838      5.985259e-04  6.222896e-04  6.467700e-04  6.719676e-04
## ASV0614     -1.628820e-03 -1.695586e-03 -1.764681e-03 -1.836154e-03
## ASV0014     -6.242394e-03 -6.503596e-03 -6.774377e-03 -7.054992e-03
## ASV0585     -4.169644e-04 -4.356576e-04 -4.551227e-04 -4.753846e-04
## ASV0016     -6.391046e-03 -6.658999e-03 -6.936823e-03 -7.224784e-03
## ASV5394     -1.681558e-03 -1.755245e-03 -1.831886e-03 -1.911576e-03
## ASV0666      1.371839e-03  1.428916e-03  1.488048e-03  1.549285e-03
## ASV2085      3.552258e-04  3.602142e-04  3.646239e-04  3.683858e-04
## ASV0003     -5.805676e-03 -6.046923e-03 -6.296884e-03 -6.555782e-03
## ASV0346      8.970891e-05  1.041589e-04  1.199748e-04  1.372531e-04
## ASV0267     -8.084384e-04 -8.356654e-04 -8.633389e-04 -8.914283e-04
## ASV0353      1.482434e-03  1.557714e-03  1.636856e-03  1.720052e-03
## ASV2419      1.618205e-03  1.684471e-03  1.753073e-03  1.824067e-03
## ASV0447      1.020902e-03  1.076362e-03  1.134855e-03  1.196533e-03
## ASV0654      2.692331e-03  2.812204e-03  2.937000e-03  3.066883e-03
## ASV0151      5.606501e-04  5.936723e-04  6.287472e-04  6.660021e-04
## ASV0065     -2.361298e-03 -2.460122e-03 -2.562541e-03 -2.668645e-03
## ASV0527      1.720285e-03  1.793082e-03  1.868611e-03  1.946950e-03
## ASV4055     -7.244466e-04 -7.598980e-04 -7.971184e-04 -8.361985e-04
## ASV0166     -1.861040e-03 -1.933480e-03 -2.008152e-03 -2.085084e-03
## ASV0417     -1.631026e-03 -1.697995e-03 -1.767339e-03 -1.839121e-03
## ASV0078     -1.244771e-03 -1.291662e-03 -1.339787e-03 -1.389136e-03
## ASV0322     -1.517842e-03 -1.575504e-03 -1.634767e-03 -1.695632e-03
## ASV0156     -2.048922e-03 -2.132102e-03 -2.218159e-03 -2.307159e-03
## ASV0648     -2.016633e-03 -2.107579e-03 -2.202402e-03 -2.301249e-03
## ASV0407      2.104853e-04  2.229353e-04  2.361513e-04  2.501793e-04
## ASV2030     -3.458166e-04 -3.578390e-04 -3.701860e-04 -3.828668e-04
## ASV0300      1.301005e-03  1.365719e-03  1.433633e-03  1.504894e-03
## ASV1150     -8.297688e-05 -8.295270e-05 -8.262505e-05 -8.196040e-05
## ASV0958      1.366065e-03  1.435179e-03  1.507890e-03  1.584387e-03
## ASV0216     -1.881432e-03 -1.954508e-03 -2.029893e-03 -2.107633e-03
## ASV0446      3.069495e-03  3.213458e-03  3.363933e-03  3.521184e-03
## ASV0367     -9.559019e-04 -9.961698e-04 -1.037949e-03 -1.081283e-03
## ASV0200     -1.823136e-03 -1.902323e-03 -1.984684e-03 -2.070326e-03
## ASV0334     -6.864458e-04 -7.030541e-04 -7.193478e-04 -7.352554e-04
## ASV1311      1.231437e-03  1.281693e-03  1.333675e-03  1.387419e-03
## ASV0458      1.359302e-03  1.416899e-03  1.476705e-03  1.538788e-03
## ASV1371      5.186626e-05  5.462476e-05  5.753032e-05  6.058990e-05
## ASV0418      1.695468e-03  1.769078e-03  1.845642e-03  1.925263e-03
## ASV0004      1.987129e-03  2.071669e-03  2.159427e-03  2.250499e-03
## ASV1943      1.398081e-03  1.455238e-03  1.514433e-03  1.575720e-03
## ASV1495     -5.012704e-04 -5.306211e-04 -5.617614e-04 -5.947984e-04
## ASV0901     -2.411153e-03 -2.522121e-03 -2.638033e-03 -2.759095e-03
## ASV0628      1.250333e-03  1.299253e-03  1.349650e-03  1.401531e-03
## ASV0400      5.023531e-04  5.220138e-04  5.422600e-04  5.630931e-04
## ASV0116     -1.918425e-03 -2.009736e-03 -2.105330e-03 -2.205399e-03
## ASV0788      1.463878e-03  1.527622e-03  1.593908e-03  1.662818e-03
## ASV0117      1.059673e-03  1.112301e-03  1.167569e-03  1.225607e-03
## ASV3137      2.408884e-04  2.505287e-04  2.604926e-04  2.707871e-04
## ASV0001      2.213962e-03  2.298993e-03  2.386527e-03  2.476582e-03
## ASV1651      1.482286e-03  1.539963e-03  1.599452e-03  1.660787e-03
## ASV1692      1.860335e-03  1.948345e-03  2.040430e-03  2.136765e-03
## ASV0660      8.334976e-04  8.608256e-04  8.884772e-04  9.163996e-04
## ASV0508      7.161046e-05  7.244368e-05  7.316873e-05  7.377604e-05
## ASV1660     -7.931644e-04 -8.317521e-04 -8.721640e-04 -9.144765e-04
## ASV0233      4.529723e-04  4.760672e-04  5.003845e-04  5.259906e-04
## ASV1343     -1.774141e-03 -1.853294e-03 -1.935776e-03 -2.021713e-03
## ASV0209      1.448264e-03  1.502982e-03  1.559264e-03  1.617124e-03
## ASV0193     -1.955091e-03 -2.032928e-03 -2.113328e-03 -2.196340e-03
## ASV0357      1.806538e-05  2.679768e-05  3.656322e-05  4.745325e-05
## ASV0198      4.631526e-04  4.842239e-04  5.062290e-04  5.292091e-04
## ASV0007      2.098767e-03  2.179388e-03  2.262384e-03  2.347773e-03
## ASV1772     -2.151947e-04 -2.231243e-04 -2.312120e-04 -2.394448e-04
## ASV0009      1.968342e-03  2.043310e-03  2.120431e-03  2.199717e-03
## ASV0006      6.727670e-04  6.915391e-04  7.102438e-04  7.288220e-04
## ASV0011     -2.510225e-03 -2.623695e-03 -2.742035e-03 -2.865432e-03
## ASV0015      1.675263e-03  1.746645e-03  1.820736e-03  1.897612e-03
## ASV0017      1.765433e-03  1.840316e-03  1.918024e-03  1.998639e-03
## ASV0235     -1.454877e-03 -1.519791e-03 -1.587398e-03 -1.657792e-03
## ASV0382      4.302404e-04  4.575353e-04  4.865058e-04  5.172370e-04
## ASV2357      2.187378e-03  2.284329e-03  2.385320e-03  2.490504e-03
## ASV0567     -1.502428e-03 -1.565020e-03 -1.629963e-03 -1.697335e-03
## ASV0165      1.695754e-03  1.768500e-03  1.844064e-03  1.922532e-03
## ASV0005      3.295958e-03  3.430459e-03  3.569569e-03  3.713379e-03
## ASV0384     -3.785983e-05 -3.234664e-05 -2.598464e-05 -1.869161e-05
## ASV0002      8.284653e-04  8.694378e-04  9.124631e-04  9.576430e-04
## ASV3017      1.881427e-03  1.956284e-03  2.033587e-03  2.113382e-03
## ASV0091      8.194685e-04  8.574202e-04  8.970577e-04  9.384478e-04
## ASV0186     -2.104718e-03 -2.197301e-03 -2.293613e-03 -2.393773e-03
## ASV0370      2.408976e-04  2.530211e-04  2.657756e-04  2.791960e-04
## ASV0018      3.456940e-03  3.599403e-03  3.746874e-03  3.899464e-03
## ASV1377      3.001130e-03  3.124339e-03  3.251895e-03  3.383900e-03
## ASV0019      3.464205e-03  3.607142e-03  3.755121e-03  3.908255e-03
## ASV0023      5.919985e-05  5.189308e-05  4.353651e-05  3.404394e-05
## ASV2194      1.241515e-03  1.299338e-03  1.359798e-03  1.423011e-03
## ASV1155     -3.667977e-05 -3.296468e-05 -2.867148e-05 -2.375082e-05
## ASV0510     -1.091152e-03 -1.126678e-03 -1.162726e-03 -1.199258e-03
## ASV2371     -1.150705e-03 -1.193658e-03 -1.237822e-03 -1.283207e-03
## ASV0024     -1.134464e-04 -1.282428e-04 -1.443858e-04 -1.619713e-04
## ASV2452      1.533391e-03  1.591295e-03  1.650784e-03  1.711855e-03
## ASV2332      2.567133e-04  2.760239e-04  2.966790e-04  3.187581e-04
## ASV2591      2.463078e-04  2.648371e-04  2.846327e-04  3.057653e-04
## ASV0521      2.448993e-03  2.562933e-03  2.682022e-03  2.806476e-03
## ASV5542      7.921771e-04  8.300266e-04  8.696029e-04  9.109744e-04
## ASV0336     -1.058787e-03 -1.103538e-03 -1.149979e-03 -1.198159e-03
## ASV10102     1.653726e-03  1.727912e-03  1.805199e-03  1.885693e-03
## ASV16823    -1.093556e-03 -1.133424e-03 -1.174358e-03 -1.216365e-03
## ASV3104      1.093118e-03  1.132955e-03  1.173856e-03  1.215828e-03
## ASV0781      5.764932e-04  5.997742e-04  6.238371e-04  6.486978e-04
## ASV10899     7.498081e-04  7.905701e-04  8.335741e-04  8.789369e-04
## ASV11222    -1.092932e-03 -1.132761e-03 -1.173656e-03 -1.215621e-03
## ASV11327    -1.092494e-03 -1.132293e-03 -1.173154e-03 -1.215084e-03
## ASV12458    -1.092058e-03 -1.131824e-03 -1.172652e-03 -1.214548e-03
## ASV1636     -8.788249e-04 -9.098402e-04 -9.415888e-04 -9.740661e-04
## ASV1890     -1.125652e-03 -1.168984e-03 -1.213702e-03 -1.259839e-03
## ASV2898      2.575760e-03  2.680465e-03  2.788762e-03  2.900729e-03
## ASV8328     -7.275601e-06  2.347594e-06  1.309149e-05  2.504267e-05
## ASV0709     -2.123682e-03 -2.210692e-03 -2.300720e-03 -2.393833e-03
## ASV0856      4.240896e-04  4.459694e-04  4.689786e-04  4.931721e-04
## ASV0909     -6.807847e-04 -6.973925e-04 -7.136801e-04 -7.295724e-04
## ASV0937     -1.763169e-03 -1.842292e-03 -1.924842e-03 -2.010964e-03
## ASV11390    -1.091190e-03 -1.130897e-03 -1.171663e-03 -1.213492e-03
## ASV11966     7.531802e-04  7.911298e-04  8.309616e-04  8.727606e-04
## ASV12990     3.512697e-04  3.665185e-04  3.823395e-04  3.987469e-04
## ASV14797     1.191068e-03  1.236993e-03  1.284295e-03  1.332991e-03
## ASV14904    -1.091177e-03 -1.130890e-03 -1.171661e-03 -1.213497e-03
## ASV15304     4.718777e-04  4.985478e-04  5.267125e-04  5.564473e-04
## ASV16696    -1.090907e-03 -1.130605e-03 -1.171361e-03 -1.213183e-03
## ASV1690      7.960396e-04  8.369643e-04  8.799232e-04  9.250024e-04
## ASV2029      3.371639e-03  3.512476e-03  3.658486e-03  3.809811e-03
## ASV2834      1.877112e-03  1.959449e-03  2.045141e-03  2.134305e-03
## ASV4003      7.293944e-04  7.707707e-04  8.145433e-04  8.608462e-04
## ASV4064      1.363633e-03  1.425387e-03  1.489751e-03  1.556818e-03
## ASV4294      5.987541e-04  6.321404e-04  6.674277e-04  7.047204e-04
## ASV4609     -8.248785e-06 -6.698916e-06 -4.958452e-06 -3.012785e-06
## ASV6283     -1.091245e-03 -1.130991e-03 -1.171801e-03 -1.213681e-03
## ASV6491     -1.090809e-03 -1.130523e-03 -1.171300e-03 -1.213146e-03
## ASV7453      6.502150e-04  6.857496e-04  7.232271e-04  7.627452e-04
## ASV7959      2.499354e-04  2.679257e-04  2.871433e-04  3.076612e-04
## ASV8219      1.090696e-03  1.130413e-03  1.171195e-03  1.213047e-03
## ASV8547     -1.090260e-03 -1.129946e-03 -1.170694e-03 -1.212511e-03
## ASV9319      9.112982e-04  9.537312e-04  9.980709e-04  1.044397e-03
## ASV9382     -1.090074e-03 -1.129751e-03 -1.170490e-03 -1.212299e-03
## ASV11516    -1.089638e-03 -1.129284e-03 -1.169990e-03 -1.211764e-03
## ASV14377    -1.089203e-03 -1.128817e-03 -1.169491e-03 -1.211229e-03
## ASV1867      1.907021e-03  1.992768e-03  2.082130e-03  2.175239e-03
## ASV1895     -3.591485e-04 -3.717462e-04 -3.846707e-04 -3.979279e-04
## ASV3168      7.216077e-04  7.489590e-04  7.770308e-04  8.058163e-04
## ASV4449      1.429644e-03  1.485714e-03  1.543637e-03  1.603455e-03
## ASV6596      1.067448e-03  1.122368e-03  1.180156e-03  1.240959e-03
## ASV7492     -2.792762e-04 -2.825341e-04 -2.852968e-04 -2.875101e-04
## ASV9854     -5.336755e-04 -5.518964e-04 -5.705271e-04 -5.895655e-04
## ASV6296      1.088476e-03  1.128048e-03  1.168678e-03  1.210372e-03
## ASV4201      6.377313e-04  6.763798e-04  7.173896e-04  7.608952e-04
## ASV0552      3.212178e-03  3.357849e-03  3.509762e-03  3.668147e-03
## ASV3671     -1.255003e-04 -1.251530e-04 -1.244297e-04 -1.233019e-04
## ASV3529     -9.882818e-05 -9.521368e-05 -9.093982e-05 -8.595900e-05
## ASV1060      8.282865e-04  8.673360e-04  9.082349e-04  9.510733e-04
## ASV0239     -1.535204e-03 -1.590683e-03 -1.647513e-03 -1.705682e-03
## ASV5711     -1.468010e-03 -1.525133e-03 -1.584093e-03 -1.644926e-03
## ASV4152     -2.042706e-03 -2.127236e-03 -2.214848e-03 -2.305626e-03
## ASV1461      1.693143e-03  1.755899e-03  1.820324e-03  1.886417e-03
## ASV2877      1.484490e-03  1.545004e-03  1.607577e-03  1.672248e-03
## ASV0012      1.275788e-03  1.336973e-03  1.401059e-03  1.468177e-03
## ASV9823      3.437283e-04  3.544891e-04  3.653368e-04  3.762491e-04
## ASV0008      1.368160e-03  1.432650e-03  1.500128e-03  1.570723e-03
## ASV7832     -1.230649e-03 -1.280598e-03 -1.332327e-03 -1.385886e-03
## ASV1915      1.751712e-04  1.857083e-04  1.968234e-04  2.085388e-04
## ASV0055      8.844640e-04  9.216066e-04  9.601020e-04  9.999824e-04
## ASV0032      2.040782e-03  2.121962e-03  2.205803e-03  2.292356e-03
## ASV2977     -1.716407e-03 -1.787177e-03 -1.860500e-03 -1.936443e-03
## ASV0466      1.650395e-03  1.713518e-03  1.778504e-03  1.845371e-03
## ASV3866      1.970475e-03  2.058663e-03  2.150577e-03  2.246361e-03
## ASV0040      2.684836e-03  2.808284e-03  2.937188e-03  3.071769e-03
## ASV0496     -3.002903e-04 -3.216520e-04 -3.445086e-04 -3.689547e-04
## ASV0052      3.000004e-03  3.124325e-03  3.253085e-03  3.386387e-03
## ASV3828     -1.817375e-03 -1.892395e-03 -1.970194e-03 -2.050859e-03
## ASV1930      1.184236e-03  1.234423e-03  1.286439e-03  1.340325e-03
## ASV2126      1.893652e-03  1.973138e-03  2.055549e-03  2.140961e-03
## ASV0793      1.335342e-03  1.401760e-03  1.471455e-03  1.544577e-03
## ASV0299     -6.448707e-04 -6.650305e-04 -6.854721e-04 -7.061805e-04
## ASV0208      1.952348e-03  2.044771e-03  2.141510e-03  2.242759e-03
## ASV0511     -7.589774e-04 -7.803056e-04 -8.015964e-04 -8.227910e-04
## ASV1123     -1.120570e-03 -1.160388e-03 -1.201139e-03 -1.242813e-03
## ASV0099     -6.513911e-04 -6.755392e-04 -7.002233e-04 -7.254179e-04
## ASV0752     -2.201146e-04 -2.328907e-04 -2.463798e-04 -2.606156e-04
## ASV0883      6.644515e-05  7.153272e-05  7.697420e-05  8.278993e-05
## ASV0683      1.727671e-03  1.808264e-03  1.892491e-03  1.980502e-03
## ASV4117     -1.838449e-03 -1.914677e-03 -1.993737e-03 -2.075717e-03
## ASV2172      7.242856e-04  7.558928e-04  7.887686e-04  8.229570e-04
## ASV0330     -1.321536e-03 -1.379468e-03 -1.439728e-03 -1.502393e-03
## ASV0728      1.334734e-03  1.396922e-03  1.461863e-03  1.529661e-03
## ASV0499      2.616321e-03  2.739477e-03  2.868330e-03  3.003134e-03
## ASV0120     -2.671341e-03 -2.784567e-03 -2.902007e-03 -3.023772e-03
## ASV1446      9.749682e-05  9.530071e-05  9.251423e-05  8.908017e-05
## ASV17171    -1.764746e-03 -1.838942e-03 -1.915981e-03 -1.995961e-03
## ASV0533      5.779312e-04  6.062569e-04  6.359786e-04  6.671638e-04
## ASV2495     -7.928198e-04 -8.307547e-04 -8.705472e-04 -9.122906e-04
## ASV5582      5.297890e-04  5.468486e-04  5.641386e-04  5.816378e-04
## ASV1488      6.386630e-04  6.687595e-04  7.002128e-04  7.330760e-04
## ASV0682      1.816587e-03  1.901696e-03  1.990695e-03  2.083751e-03
## ASV0068     -2.251751e-04 -2.409775e-04 -2.578394e-04 -2.758203e-04
## ASV1987     -1.072650e-03 -1.126899e-03 -1.183899e-03 -1.243784e-03
## ASV0035      9.537259e-05  8.687225e-05  7.693450e-05  6.541906e-05
## ASV7192     -1.098237e-03 -1.139353e-03 -1.181614e-03 -1.225025e-03
## ASV0873      7.700627e-05  7.565690e-05  7.395331e-05  7.186960e-05
## ASV4749     -1.003263e-04 -1.154165e-04 -1.319631e-04 -1.500769e-04
## ASV2174      1.012283e-03  1.048536e-03  1.085692e-03  1.123751e-03
## ASV1476     -1.034308e-03 -1.080839e-03 -1.129413e-03 -1.180117e-03
## ASV0740     -2.621152e-03 -2.742706e-03 -2.869710e-03 -3.002392e-03
## ASV0170      5.268266e-04  5.499116e-04  5.739482e-04  5.989723e-04
## ASV2466     -2.225578e-03 -2.321985e-03 -2.422297e-03 -2.526659e-03
## ASV1709      1.679648e-03  1.749568e-03  1.822062e-03  1.897201e-03
## ASV6170     -1.645330e-03 -1.718881e-03 -1.795520e-03 -1.875359e-03
## ASV3673      1.889861e-03  1.974693e-03  2.063114e-03  2.155258e-03
## ASV1745      1.479354e-04  1.545975e-04  1.615309e-04  1.687434e-04
##                                                                    
## (Intercept) -3.894455e-04 -4.342632e-04 -4.837086e-04 -5.381835e-04
## ASV1236      1.419049e-03  1.472904e-03  1.528347e-03  1.585394e-03
## ASV0421     -2.565402e-03 -2.664513e-03 -2.766640e-03 -2.871823e-03
## ASV0691     -2.069245e-03 -2.141668e-03 -2.215799e-03 -2.291631e-03
## ASV0899      6.834385e-05  7.511172e-05  8.230805e-05  8.994346e-05
## ASV1004      2.918611e-03  3.031206e-03  3.147182e-03  3.266575e-03
## ASV1041     -1.974268e-03 -2.049851e-03 -2.127606e-03 -2.207541e-03
## ASV1058      2.725034e-03  2.831343e-03  2.940998e-03  3.054057e-03
## ASV12542     7.567682e-04  7.825254e-04  8.088329e-04  8.356850e-04
## ASV1294      3.248720e-03  3.379313e-03  3.514294e-03  3.653755e-03
## ASV13113     1.347592e-03  1.411772e-03  1.478982e-03  1.549361e-03
## ASV1318      2.764826e-03  2.872444e-03  2.983394e-03  3.097724e-03
## ASV2269     -8.250275e-04 -8.569566e-04 -8.898379e-04 -9.236797e-04
## ASV2542      2.018056e-03  2.109671e-03  2.205245e-03  2.304933e-03
## ASV2660     -1.536377e-03 -1.593256e-03 -1.651673e-03 -1.711634e-03
## ASV2737     -1.360501e-04 -1.435960e-04 -1.515100e-04 -1.598024e-04
## ASV2840      2.006779e-03  2.078853e-03  2.152663e-03  2.228196e-03
## ASV3053      9.632601e-05  9.946704e-05  1.026904e-04  1.060002e-04
## ASV3077      6.429890e-04  6.674595e-04  6.926770e-04  7.186554e-04
## ASV3134      2.673164e-03  2.798508e-03  2.929628e-03  3.066778e-03
## ASV3140      1.122537e-03  1.171993e-03  1.223428e-03  1.276902e-03
## ASV3579      5.831430e-04  6.156636e-04  6.500431e-04  6.863824e-04
## ASV6119     -8.242758e-04 -8.561545e-04 -8.889834e-04 -9.227707e-04
## ASV7557     -8.238320e-04 -8.556756e-04 -8.884669e-04 -9.222140e-04
## ASV8422      4.195563e-04  4.344290e-04  4.496914e-04  4.653483e-04
## ASV1086     -2.090454e-04 -2.164620e-04 -2.240838e-04 -2.319156e-04
## ASV1310      1.611703e-03  1.676317e-03  1.743044e-03  1.811914e-03
## ASV15750    -3.678590e-04 -3.807544e-04 -3.939122e-04 -4.073232e-04
## ASV16905    -8.236616e-04 -8.554931e-04 -8.882717e-04 -9.220057e-04
## ASV2033      1.790588e-03  1.872942e-03  1.958891e-03  2.048571e-03
## ASV2089      5.701682e-04  5.924090e-04  6.153183e-04  6.389013e-04
## ASV2127      2.278123e-03  2.368222e-03  2.461245e-03  2.557243e-03
## ASV2725      2.447586e-03  2.537776e-03  2.630373e-03  2.725382e-03
## ASV2804     -8.236592e-04 -8.554973e-04 -8.882840e-04 -9.220277e-04
## ASV3075      1.699260e-03  1.770836e-03  1.845196e-03  1.922442e-03
## ASV3327      1.720906e-03  1.799047e-03  1.880559e-03  1.965572e-03
## ASV3342      1.807356e-03  1.886010e-03  1.967795e-03  2.052814e-03
## ASV3532     -1.627739e-03 -1.698759e-03 -1.772661e-03 -1.849549e-03
## ASV3600      2.044859e-03  2.133150e-03  2.224933e-03  2.320322e-03
## ASV4013      1.623462e-03  1.688565e-03  1.755838e-03  1.825321e-03
## ASV4136      1.543571e-03  1.602509e-03  1.663229e-03  1.725758e-03
## ASV4195      8.230866e-04  8.548829e-04  8.876251e-04  9.213215e-04
## ASV4407     -8.226440e-04 -8.544052e-04 -8.871100e-04 -9.207664e-04
## ASV4717     -1.156009e-06 -3.150861e-06 -5.317566e-06 -7.662052e-06
## ASV6794      7.859980e-04  8.141801e-04  8.431299e-04  8.728598e-04
## ASV8324     -8.224507e-04 -8.541945e-04 -8.868805e-04 -9.205168e-04
## ASV8981     -1.343242e-04 -1.346439e-04 -1.345360e-04 -1.339547e-04
## ASV9859      8.369988e-04  8.812528e-04  9.279388e-04  9.771918e-04
## ASV0936     -1.321495e-03 -1.374567e-03 -1.429426e-03 -1.486110e-03
## ASV12683    -1.730448e-04 -1.814672e-04 -1.902501e-04 -1.994024e-04
## ASV1293      1.889662e-03  1.962368e-03  2.037275e-03  2.114410e-03
## ASV13055    -1.682960e-04 -1.729199e-04 -1.775118e-04 -1.820556e-04
## ASV17063    -8.219681e-04 -8.536917e-04 -8.863586e-04 -9.199772e-04
## ASV2228      8.215265e-04  8.532152e-04  8.858447e-04  9.194233e-04
## ASV2769     -7.643619e-05 -7.550673e-05 -7.424211e-05 -7.261549e-05
## ASV2803      3.471100e-04  3.587239e-04  3.705852e-04  3.826929e-04
## ASV2896      1.140875e-03  1.192048e-03  1.245494e-03  1.301317e-03
## ASV3062      4.604930e-04  4.862929e-04  5.135706e-04  5.424057e-04
## ASV3107      1.358561e-03  1.417724e-03  1.479278e-03  1.543310e-03
## ASV3265      2.447327e-03  2.540858e-03  2.637154e-03  2.736243e-03
## ASV3666     -7.550081e-05 -7.953999e-05 -8.381013e-05 -8.832545e-05
## ASV4497      5.877419e-04  6.107174e-04  6.344189e-04  6.588581e-04
## ASV6914     -3.163007e-04 -3.298997e-04 -3.440139e-04 -3.586575e-04
## ASV0576     -2.748154e-03 -2.846931e-03 -2.948231e-03 -3.052059e-03
## ASV0673      9.102455e-04  9.526555e-04  9.968644e-04  1.042927e-03
## ASV0772      9.352619e-04  9.745747e-04  1.015382e-03  1.057731e-03
## ASV0862     -6.118570e-04 -6.304830e-04 -6.492674e-04 -6.681795e-04
## ASV0898      8.953409e-04  9.383789e-04  9.833925e-04  1.030459e-03
## ASV0910      1.865650e-03  1.953105e-03  2.044504e-03  2.140005e-03
## ASV0964     -1.012235e-03 -1.049073e-03 -1.086841e-03 -1.125532e-03
## ASV10059     8.988351e-04  9.425691e-04  9.884265e-04  1.036506e-03
## ASV10263    -8.242579e-04 -8.561873e-04 -8.890781e-04 -9.229405e-04
## ASV1088      1.014979e-03  1.064410e-03  1.116275e-03  1.170695e-03
## ASV1101      1.478602e-03  1.537825e-03  1.598926e-03  1.661926e-03
## ASV1183      9.853031e-04  1.027203e-03  1.070686e-03  1.115799e-03
## ASV11956     2.947414e-04  3.035341e-04  3.124344e-04  3.214363e-04
## ASV12774    -1.604953e-04 -1.684836e-04 -1.768519e-04 -1.856156e-04
## ASV1321      5.442155e-04  5.749843e-04  6.075081e-04  6.418785e-04
## ASV13793    -8.237286e-04 -8.556159e-04 -8.884616e-04 -9.222759e-04
## ASV14482    -1.118715e-04 -1.176187e-04 -1.236130e-04 -1.298589e-04
## ASV15483     6.488608e-04  6.778781e-04  7.081140e-04  7.396122e-04
## ASV2062      3.810885e-03  3.968341e-03  4.131434e-03  4.300306e-03
## ASV2132      1.853157e-03  1.935942e-03  2.022201e-03  2.112059e-03
## ASV2413      2.365297e-03  2.458634e-03  2.555023e-03  2.654525e-03
## ASV2490      1.482456e-03  1.536994e-03  1.592987e-03  1.650440e-03
## ASV2594      9.157690e-04  9.559391e-04  9.978355e-04  1.041535e-03
## ASV2822     -8.246856e-04 -8.566650e-04 -8.896117e-04 -9.235366e-04
## ASV2863      1.413060e-03  1.467140e-03  1.522857e-03  1.580233e-03
## ASV2910      1.830880e-03  1.900328e-03  1.971817e-03  2.045371e-03
## ASV2980      6.621876e-04  6.868658e-04  7.122021e-04  7.381957e-04
## ASV3307      8.239538e-04  8.558756e-04  8.887608e-04  9.226200e-04
## ASV3474      1.535142e-03  1.607740e-03  1.683650e-03  1.763006e-03
## ASV3502      2.846213e-03  2.965764e-03  3.089791e-03  3.218425e-03
## ASV4236      1.304338e-03  1.352206e-03  1.401331e-03  1.451715e-03
## ASV4842     -4.628344e-04 -4.811357e-04 -4.999933e-04 -5.194108e-04
## ASV4894     -8.246448e-04 -8.566328e-04 -8.895904e-04 -9.235289e-04
## ASV5290      1.073822e-03  1.118456e-03  1.164672e-03  1.212505e-03
## ASV5501      2.037012e-04  2.127503e-04  2.222101e-04  2.321016e-04
## ASV5795      7.833697e-04  8.191536e-04  8.564854e-04  8.954227e-04
## ASV5987     -8.249510e-04 -8.569712e-04 -8.899644e-04 -9.239421e-04
## ASV6267     -8.245054e-04 -8.564902e-04 -8.894454e-04 -9.233823e-04
## ASV6862      1.484480e-03  1.537663e-03  1.592206e-03  1.648115e-03
## ASV7145      2.603252e-04  2.695436e-04  2.790397e-04  2.888239e-04
## ASV7673     -8.243435e-04 -8.563144e-04 -8.892547e-04 -9.231757e-04
## ASV7789      4.566247e-04  4.831026e-04  5.111636e-04  5.408982e-04
## ASV7809     -2.557034e-05 -2.250591e-05 -1.901244e-05 -1.505732e-05
## ASV8002     -8.242376e-04 -8.562136e-04 -8.891611e-04 -9.230918e-04
## ASV8205      5.191541e-04  5.418867e-04  5.655726e-04  5.902500e-04
## ASV9155     -6.098755e-04 -6.329192e-04 -6.566095e-04 -6.809498e-04
## ASV9221     -2.106145e-06  2.950512e-06  8.614478e-06  1.493423e-05
## ASV9311     -8.237883e-04 -8.557379e-04 -8.886584e-04 -9.225615e-04
## ASV9557     -8.233438e-04 -8.552579e-04 -8.881404e-04 -9.220030e-04
## ASV9936     -8.228997e-04 -8.547785e-04 -8.876231e-04 -9.214451e-04
## ASV1445      2.105606e-03  2.198575e-03  2.295374e-03  2.396141e-03
## ASV4232      1.886685e-03  1.976068e-03  2.069681e-03  2.167722e-03
## ASV6479      1.434163e-04  1.571256e-04  1.719579e-04  1.879907e-04
## ASV0142     -4.056028e-03 -4.208784e-03 -4.365931e-03 -4.527510e-03
## ASV0378     -1.248464e-03 -1.290468e-03 -1.333191e-03 -1.376590e-03
## ASV1122      2.782629e-03  2.905031e-03  3.032394e-03  3.164885e-03
## ASV0123     -3.963086e-03 -4.111782e-03 -4.264703e-03 -4.421885e-03
## ASV2064      3.534682e-04  3.638722e-04  3.743489e-04  3.848819e-04
## ASV4459     -4.397160e-04 -4.562217e-04 -4.731988e-04 -4.906531e-04
## ASV0448      9.741827e-04  1.025598e-03  1.079733e-03  1.136722e-03
## ASV0397      2.026546e-03  2.113119e-03  2.203011e-03  2.296320e-03
## ASV0485      2.748367e-03  2.862275e-03  2.980367e-03  3.102767e-03
## ASV1566      2.359188e-03  2.459041e-03  2.562632e-03  2.670064e-03
## ASV1365      1.544838e-03  1.611013e-03  1.679714e-03  1.751012e-03
## ASV1065      3.151477e-03  3.286319e-03  3.426373e-03  3.571803e-03
## ASV0722     -3.666757e-05 -3.719842e-05 -3.770746e-05 -3.819549e-05
## ASV12660    -1.319370e-03 -1.368425e-03 -1.418855e-03 -1.470673e-03
## ASV0223     -3.581637e-05 -3.587676e-05 -3.578986e-05 -3.553595e-05
## ASV0229      1.478400e-03  1.545330e-03  1.615152e-03  1.687979e-03
## ASV0877     -4.261786e-04 -4.392840e-04 -4.525561e-04 -4.659843e-04
## ASV0983      2.745315e-03  2.855470e-03  2.969338e-03  3.086999e-03
## ASV0626     -6.961343e-04 -7.141393e-04 -7.320342e-04 -7.497728e-04
## ASV4146     -1.368355e-04 -1.418544e-04 -1.470435e-04 -1.524131e-04
## ASV4175     -1.757479e-03 -1.831541e-03 -1.908354e-03 -1.987993e-03
## ASV2082     -2.491661e-04 -2.664564e-04 -2.849810e-04 -3.048227e-04
## ASV2272      1.340244e-03  1.400830e-03  1.464032e-03  1.529954e-03
## ASV2245     -1.560318e-03 -1.627563e-03 -1.697429e-03 -1.769997e-03
## ASV0590     -1.122107e-03 -1.179039e-03 -1.238843e-03 -1.301654e-03
## ASV0217     -9.347537e-04 -9.509597e-04 -9.660655e-04 -9.799299e-04
## ASV0416      1.185737e-03  1.224345e-03  1.263568e-03  1.303369e-03
## ASV1056      1.893932e-03  1.983237e-03  2.076552e-03  2.174030e-03
## ASV7777     -1.529842e-03 -1.595316e-03 -1.663344e-03 -1.734013e-03
## ASV0455      3.599555e-04  3.772593e-04  3.953140e-04  4.141407e-04
## ASV0604      4.937382e-04  5.221992e-04  5.522686e-04  5.840250e-04
## ASV6100     -1.427103e-03 -1.488971e-03 -1.553324e-03 -1.620250e-03
## ASV11359    -1.542133e-03 -1.605798e-03 -1.671722e-03 -1.739958e-03
## ASV6604      1.193967e-03  1.248692e-03  1.305827e-03  1.365469e-03
## ASV5004     -9.019386e-04 -9.392204e-04 -9.778566e-04 -1.017886e-03
## ASV1483     -8.465255e-04 -8.821814e-04 -9.191758e-04 -9.575488e-04
## ASV9773     -1.814047e-03 -1.891847e-03 -1.972688e-03 -2.056670e-03
## ASV4059      2.754607e-04  2.923698e-04  3.103252e-04  3.293858e-04
## ASV1193      2.919513e-03  3.042700e-03  3.170500e-03  3.303045e-03
## ASV4610     -7.899261e-05 -7.456546e-05 -6.947193e-05 -6.366916e-05
## ASV0742     -8.216305e-04 -8.435080e-04 -8.652944e-04 -8.869332e-04
## ASV1502     -1.035074e-04 -1.120335e-04 -1.211842e-04 -1.309968e-04
## ASV0195     -4.281909e-04 -4.510371e-04 -4.750647e-04 -5.003266e-04
## ASV1213      7.853752e-04  8.116374e-04  8.383602e-04  8.655208e-04
## ASV1648     -1.331278e-03 -1.388007e-03 -1.446950e-03 -1.508182e-03
## ASV6984     -1.020573e-03 -1.065344e-03 -1.111969e-03 -1.160521e-03
## ASV0396     -3.778259e-04 -3.762127e-04 -3.732829e-04 -3.689234e-04
## ASV4297      1.357828e-03  1.408542e-03  1.460692e-03  1.514291e-03
## ASV2622      3.186902e-03  3.310822e-03  3.438640e-03  3.570426e-03
## ASV3512      7.017157e-04  7.408313e-04  7.822175e-04  8.260051e-04
## ASV2411      1.294911e-03  1.355700e-03  1.419243e-03  1.485651e-03
## ASV2291     -4.084124e-04 -4.313971e-04 -4.557039e-04 -4.814043e-04
## ASV0807      1.638318e-03  1.720062e-03  1.805784e-03  1.895653e-03
## ASV1292      7.230965e-04  7.517207e-04  7.813178e-04  8.119144e-04
## ASV1035      2.940572e-04  3.039232e-04  3.140326e-04  3.243907e-04
## ASV0070     -5.684297e-04 -5.799519e-04 -5.908978e-04 -6.011747e-04
## ASV0255      3.206566e-04  3.330847e-04  3.458169e-04  3.588392e-04
## ASV0057     -3.089865e-03 -3.198897e-03 -3.310376e-03 -3.424255e-03
## ASV0077     -3.034958e-04 -3.057769e-04 -3.073378e-04 -3.081036e-04
## ASV0625      3.207083e-03  3.327906e-03  3.452171e-03  3.579904e-03
## ASV2464      1.498608e-03  1.553013e-03  1.608864e-03  1.666167e-03
## ASV1315      3.309005e-03  3.461620e-03  3.620973e-03  3.787328e-03
## ASV2673      2.465548e-03  2.582540e-03  2.705003e-03  2.833182e-03
## ASV2161      1.031494e-03  1.081199e-03  1.133283e-03  1.187855e-03
## ASV0337     -1.420557e-03 -1.477995e-03 -1.537369e-03 -1.598715e-03
## ASV7680     -1.759608e-03 -1.835776e-03 -1.914963e-03 -1.997271e-03
## ASV0611      3.980479e-03  4.161169e-03  4.349738e-03  4.546506e-03
## ASV3118     -1.332744e-03 -1.391889e-03 -1.453475e-03 -1.517589e-03
## ASV1284      1.404154e-03  1.466538e-03  1.531519e-03  1.599190e-03
## ASV0889      9.927576e-04  1.033594e-03  1.075931e-03  1.119814e-03
## ASV4649     -1.071540e-03 -1.116844e-03 -1.163858e-03 -1.212633e-03
## ASV1108     -1.536925e-03 -1.610514e-03 -1.687574e-03 -1.768257e-03
## ASV0738      1.736459e-04  1.999877e-04  2.287903e-04  2.602297e-04
## ASV0473      2.257586e-04  2.363535e-04  2.474546e-04  2.590864e-04
## ASV0598     -1.334554e-03 -1.380461e-03 -1.427328e-03 -1.475134e-03
## ASV0429      2.392526e-03  2.488897e-03  2.588499e-03  2.691393e-03
## ASV1549      2.770245e-03  2.902471e-03  3.040895e-03  3.185789e-03
## ASV1203      1.842591e-03  1.918754e-03  1.997637e-03  2.079307e-03
## ASV4532      4.071369e-05  4.107917e-05  4.142609e-05  4.176015e-05
## ASV0274     -1.638743e-03 -1.696477e-03 -1.755557e-03 -1.815974e-03
## ASV0163     -2.308420e-03 -2.387934e-03 -2.469138e-03 -2.552001e-03
## ASV1298      9.447910e-04  9.782749e-04  1.012617e-03  1.047826e-03
## ASV9424     -2.379740e-03 -2.485263e-03 -2.595182e-03 -2.709663e-03
## ASV0412      3.435462e-03  3.576649e-03  3.722873e-03  3.874262e-03
## ASV0284      1.400334e-03  1.451174e-03  1.503318e-03  1.556764e-03
## ASV0620     -1.324294e-03 -1.387267e-03 -1.453119e-03 -1.521966e-03
## ASV0153     -2.634626e-03 -2.755024e-03 -2.880627e-03 -3.011630e-03
## ASV0498      5.435373e-04  5.792306e-04  6.171320e-04  6.573510e-04
## ASV0097      1.936671e-03  2.028255e-03  2.124104e-03  2.224407e-03
## ASV0104     -8.028449e-03 -8.363601e-03 -8.711026e-03 -9.071051e-03
## ASV1282      1.458077e-03  1.521678e-03  1.587779e-03  1.656456e-03
## ASV3883     -9.026327e-04 -9.445588e-04 -9.883073e-04 -1.033941e-03
## ASV0801      9.556796e-04  1.002692e-03  1.051965e-03  1.103598e-03
## ASV1611     -3.246029e-03 -3.389674e-03 -3.539254e-03 -3.694982e-03
## ASV0227     -1.341184e-03 -1.407927e-03 -1.477933e-03 -1.551347e-03
## ASV0833      1.428618e-03  1.498860e-03  1.572443e-03  1.649508e-03
## ASV0718      2.946665e-03  3.073263e-03  3.204781e-03  3.341370e-03
## ASV1139      8.312759e-04  8.544033e-04  8.774468e-04  9.003338e-04
## ASV0766     -7.281800e-04 -7.556606e-04 -7.839292e-04 -8.129939e-04
## ASV2091      3.544406e-03  3.677037e-03  3.813405e-03  3.953539e-03
## ASV1238     -4.976424e-05 -4.218058e-05 -3.358599e-05 -2.390373e-05
## ASV9193     -5.160905e-04 -5.458706e-04 -5.773574e-04 -6.106379e-04
## ASV0290     -4.310989e-04 -4.536898e-04 -4.773648e-04 -5.021574e-04
## ASV0231      3.037943e-03  3.164270e-03  3.295206e-03  3.430873e-03
## ASV0185      1.154702e-03  1.234603e-03  1.320007e-03  1.411264e-03
## ASV2330      8.225102e-04  8.540212e-04  8.864880e-04  9.199256e-04
## ASV3119     -1.263450e-03 -1.329582e-03 -1.399204e-03 -1.472489e-03
## ASV2368     -1.545437e-03 -1.618441e-03 -1.694866e-03 -1.774870e-03
## ASV0122     -9.815016e-04 -1.017014e-03 -1.053441e-03 -1.090785e-03
## ASV1044      2.214585e-03  2.322578e-03  2.435759e-03  2.554362e-03
## ASV0160     -2.332237e-03 -2.411127e-03 -2.491533e-03 -2.573405e-03
## ASV0326      1.793170e-03  1.869780e-03  1.949299e-03  2.031807e-03
## ASV1388      3.080251e-03  3.209429e-03  3.343410e-03  3.482333e-03
## ASV0792      3.346701e-03  3.479362e-03  3.616303e-03  3.757594e-03
## ASV0036     -2.343014e-03 -2.447824e-03 -2.556968e-03 -2.670590e-03
## ASV2125      3.593075e-03  3.743078e-03  3.898559e-03  4.059661e-03
## ASV1075      7.733749e-04  8.102960e-04  8.489504e-04  8.894145e-04
## ASV0390      8.880377e-04  9.368011e-04  9.883518e-04  1.042849e-03
## ASV3790     -3.006501e-03 -3.138282e-03 -3.275395e-03 -3.418024e-03
## ASV1535     -3.252003e-04 -3.436187e-04 -3.631130e-04 -3.837428e-04
## ASV0263      6.130137e-04  6.394752e-04  6.669781e-04  6.955566e-04
## ASV0675      5.184982e-03  5.424657e-03  5.674988e-03  5.936405e-03
## ASV3348      5.606063e-04  5.896784e-04  6.202875e-04  6.525127e-04
## ASV0058     -4.466382e-03 -4.649129e-03 -4.838219e-03 -5.033789e-03
## ASV4142      1.096450e-03  1.139807e-03  1.184543e-03  1.230680e-03
## ASV0059     -3.821728e-03 -3.976423e-03 -4.136340e-03 -4.301578e-03
## ASV0013     -8.148865e-03 -8.489302e-03 -8.842254e-03 -9.208065e-03
## ASV0033     -2.570978e-03 -2.687179e-03 -2.808301e-03 -2.934520e-03
## ASV4354     -9.812879e-04 -1.019865e-03 -1.059740e-03 -1.100948e-03
## ASV0022     -2.693308e-03 -2.813939e-03 -2.939578e-03 -3.070394e-03
## ASV0134     -7.520283e-04 -7.896037e-04 -8.290329e-04 -8.704021e-04
## ASV0415     -3.124474e-04 -3.154036e-04 -3.177635e-04 -3.194697e-04
## ASV10103    -1.842263e-03 -1.922951e-03 -2.006887e-03 -2.094178e-03
## ASV1613      2.737549e-03  2.845320e-03  2.956490e-03  3.071104e-03
## ASV0135      1.493777e-04  1.714874e-04  1.957042e-04  2.221861e-04
## ASV0469     -3.397191e-03 -3.531089e-03 -3.669352e-03 -3.812067e-03
## ASV0471      2.321063e-03  2.420760e-03  2.524344e-03  2.631941e-03
## ASV0451     -7.655812e-04 -8.050028e-04 -8.464499e-04 -8.900181e-04
## ASV0747      1.045805e-03  1.097509e-03  1.151697e-03  1.208473e-03
## ASV1314     -1.579934e-03 -1.658612e-03 -1.741279e-03 -1.828137e-03
## ASV0425     -3.685975e-03 -3.821752e-03 -3.961138e-03 -4.104136e-03
## ASV0559     -2.114052e-03 -2.194393e-03 -2.277246e-03 -2.362669e-03
## ASV0148     -2.225386e-03 -2.304189e-03 -2.384752e-03 -2.467036e-03
## ASV0129     -9.254356e-04 -9.477082e-04 -9.694850e-04 -9.906535e-04
## ASV1072      1.049658e-03  1.084987e-03  1.120931e-03  1.157454e-03
## ASV2390      7.457808e-04  7.704994e-04  7.955884e-04  8.210154e-04
## ASV0548      2.710911e-03  2.829299e-03  2.952438e-03  3.080489e-03
## ASV0168     -3.801411e-03 -3.954055e-03 -4.111889e-03 -4.275033e-03
## ASV0066     -2.863754e-03 -2.980343e-03 -3.100933e-03 -3.225606e-03
## ASV0468     -1.093918e-03 -1.140701e-03 -1.189320e-03 -1.239837e-03
## ASV0172     -3.094219e-04 -3.070274e-04 -3.033528e-04 -2.982778e-04
## ASV0236     -1.105735e-03 -1.131292e-03 -1.156204e-03 -1.180344e-03
## ASV0250      5.663460e-04  6.154375e-04  6.683854e-04  7.254520e-04
## ASV0338      2.427726e-05  3.619384e-05  4.927674e-05  6.359604e-05
## ASV0450     -9.062937e-06 -9.297984e-06 -9.550235e-06 -9.824744e-06
## ASV0377      3.225174e-03  3.360956e-03  3.501790e-03  3.647815e-03
## ASV1022      9.285919e-04  9.696875e-04  1.012520e-03  1.057158e-03
## ASV6174     -2.047726e-04 -2.129901e-04 -2.215238e-04 -2.303870e-04
## ASV0786      2.937552e-04  3.030396e-04  3.124587e-04  3.220037e-04
## ASV0053     -3.914827e-03 -4.081327e-03 -4.254156e-03 -4.433498e-03
## ASV0697     -9.610172e-04 -9.936265e-04 -1.026877e-03 -1.060750e-03
## ASV0785      2.900418e-03  3.023168e-03  3.150556e-03  3.282719e-03
## ASV1967     -1.731111e-03 -1.796084e-03 -1.862954e-03 -1.931745e-03
## ASV0385     -7.407207e-04 -7.646946e-04 -7.890458e-04 -8.137533e-04
## ASV0295      2.712275e-04  2.965146e-04  3.238820e-04  3.534774e-04
## ASV0072     -2.816752e-03 -2.920689e-03 -3.027313e-03 -3.136611e-03
## ASV0157     -1.034867e-03 -1.064745e-03 -1.094561e-03 -1.124212e-03
## ASV0501      1.605288e-03  1.682812e-03  1.764006e-03  1.849028e-03
## ASV10729    -2.439369e-03 -2.545728e-03 -2.656321e-03 -2.771286e-03
## ASV1470      1.045025e-03  1.084890e-03  1.125904e-03  1.168076e-03
## ASV0050     -7.545838e-03 -7.853182e-03 -8.171170e-03 -8.500044e-03
## ASV0411     -7.932278e-05 -7.643627e-05 -7.295579e-05 -6.883080e-05
## ASV0549      1.646489e-03  1.725159e-03  1.807532e-03  1.893775e-03
## ASV0184      9.147506e-04  9.544487e-04  9.957863e-04  1.038829e-03
## ASV0705      1.162601e-03  1.214603e-03  1.268715e-03  1.324999e-03
## ASV1715      2.806643e-03  2.927942e-03  3.054036e-03  3.185080e-03
## ASV0603      3.785198e-04  3.976677e-04  4.178507e-04  4.391310e-04
## ASV0826      8.236977e-04  8.535323e-04  8.841143e-04  9.154403e-04
## ASV0034     -3.297543e-03 -3.425435e-03 -3.557187e-03 -3.692835e-03
## ASV0838      6.978800e-04  7.245026e-04  7.518274e-04  7.798435e-04
## ASV0614     -1.910058e-03 -1.986439e-03 -2.065344e-03 -2.146819e-03
## ASV0014     -7.345697e-03 -7.646748e-03 -7.958401e-03 -8.280911e-03
## ASV0585     -4.964679e-04 -5.183973e-04 -5.411972e-04 -5.648914e-04
## ASV0016     -7.523150e-03 -7.832189e-03 -8.152169e-03 -8.483358e-03
## ASV5394     -1.994413e-03 -2.080494e-03 -2.169916e-03 -2.262780e-03
## ASV0666      1.612677e-03  1.678273e-03  1.746121e-03  1.816268e-03
## ASV2085      3.714269e-04  3.736706e-04  3.750360e-04  3.754390e-04
## ASV0003     -6.823839e-03 -7.101276e-03 -7.388314e-03 -7.685173e-03
## ASV0346      1.560946e-04  1.766045e-04  1.988926e-04  2.230726e-04
## ASV0267     -9.198996e-04 -9.487158e-04 -9.778367e-04 -1.007219e-03
## ASV0353      1.807501e-03  1.899408e-03  1.995990e-03  2.097470e-03
## ASV2419      1.897512e-03  1.973466e-03  2.051985e-03  2.133127e-03
## ASV0447      1.261555e-03  1.330086e-03  1.402295e-03  1.478357e-03
## ASV0654      3.202016e-03  3.342566e-03  3.488702e-03  3.640591e-03
## ASV0151      7.055713e-04  7.475965e-04  7.922267e-04  8.396185e-04
## ASV0065     -2.778522e-03 -2.892259e-03 -3.009943e-03 -3.131658e-03
## ASV0527      2.028175e-03  2.112364e-03  2.199595e-03  2.289946e-03
## ASV4055     -8.772340e-04 -9.203259e-04 -9.655801e-04 -1.013109e-03
## ASV0166     -2.164301e-03 -2.245828e-03 -2.329686e-03 -2.415893e-03
## ASV0417     -1.913401e-03 -1.990240e-03 -2.069698e-03 -2.151838e-03
## ASV0078     -1.439689e-03 -1.491424e-03 -1.544313e-03 -1.598320e-03
## ASV0322     -1.758092e-03 -1.822137e-03 -1.887754e-03 -1.954924e-03
## ASV0156     -2.399170e-03 -2.494258e-03 -2.592490e-03 -2.693931e-03
## ASV0648     -2.404271e-03 -2.511621e-03 -2.623458e-03 -2.739946e-03
## ASV0407      2.650674e-04  2.808663e-04  2.976289e-04  3.154109e-04
## ASV2030     -3.958921e-04 -4.092737e-04 -4.230253e-04 -4.371622e-04
## ASV0300      1.579655e-03  1.658073e-03  1.740310e-03  1.826534e-03
## ASV1150     -8.092290e-05 -7.947429e-05 -7.757382e-05 -7.517824e-05
## ASV0958      1.664871e-03  1.749552e-03  1.838650e-03  1.932398e-03
## ASV0216     -2.187774e-03 -2.270361e-03 -2.355443e-03 -2.443066e-03
## ASV0446      3.685484e-03  3.857112e-03  4.036357e-03  4.223512e-03
## ASV0367     -1.126218e-03 -1.172799e-03 -1.221074e-03 -1.271088e-03
## ASV0200     -2.159363e-03 -2.251910e-03 -2.348082e-03 -2.448001e-03
## ASV0334     -7.507016e-04 -7.656071e-04 -7.798884e-04 -7.934587e-04
## ASV1311      1.442958e-03  1.500324e-03  1.559550e-03  1.620665e-03
## ASV0458      1.603220e-03  1.670072e-03  1.739419e-03  1.811336e-03
## ASV1371      6.381060e-05  6.719967e-05  7.076446e-05  7.451243e-05
## ASV0418      2.008048e-03  2.094106e-03  2.183548e-03  2.276489e-03
## ASV0004      2.344979e-03  2.442966e-03  2.544557e-03  2.649852e-03
## ASV1943      1.639153e-03  1.704787e-03  1.772678e-03  1.842880e-03
## ASV1495     -6.298450e-04 -6.670198e-04 -7.064477e-04 -7.482596e-04
## ASV0901     -2.885521e-03 -3.017534e-03 -3.155362e-03 -3.299242e-03
## ASV0628      1.454904e-03  1.509769e-03  1.566125e-03  1.623966e-03
## ASV0400      5.845130e-04  6.065177e-04  6.291034e-04  6.522637e-04
## ASV0116     -2.310140e-03 -2.419759e-03 -2.534471e-03 -2.654495e-03
## ASV0788      1.734437e-03  1.808850e-03  1.886144e-03  1.966406e-03
## ASV0117      1.286551e-03  1.350542e-03  1.417728e-03  1.488262e-03
## ASV3137      2.814194e-04  2.923971e-04  3.037275e-04  3.154184e-04
## ASV0001      2.569175e-03  2.664316e-03  2.762013e-03  2.862271e-03
## ASV1651      1.723997e-03  1.789115e-03  1.856172e-03  1.925198e-03
## ASV1692      2.237535e-03  2.342927e-03  2.453137e-03  2.568366e-03
## ASV0660      9.445342e-04  9.728155e-04  1.001172e-03  1.029523e-03
## ASV0508      7.425587e-05  7.459833e-05  7.479346e-05  7.483123e-05
## ASV1660     -9.587682e-04 -1.005119e-03 -1.053613e-03 -1.104331e-03
## ASV0233      5.529555e-04  5.813529e-04  6.112605e-04  6.427596e-04
## ASV1343     -2.111233e-03 -2.204469e-03 -2.301558e-03 -2.402641e-03
## ASV0209      1.676570e-03  1.737612e-03  1.800256e-03  1.864507e-03
## ASV0193     -2.282013e-03 -2.370394e-03 -2.461530e-03 -2.555468e-03
## ASV0357      5.956544e-05  7.300425e-05  8.788121e-05  1.043153e-04
## ASV0198      5.532074e-04  5.782693e-04  6.044424e-04  6.317770e-04
## ASV0007      2.435571e-03  2.525789e-03  2.618434e-03  2.713510e-03
## ASV1772     -2.478076e-04 -2.562822e-04 -2.648477e-04 -2.734799e-04
## ASV0009      2.281176e-03  2.364814e-03  2.450630e-03  2.538623e-03
## ASV0006      7.472102e-04  7.653406e-04  7.831405e-04  8.005328e-04
## ASV0011     -2.994079e-03 -3.128175e-03 -3.267925e-03 -3.413536e-03
## ASV0015      1.977351e-03  2.060031e-03  2.145731e-03  2.234528e-03
## ASV0017      2.082243e-03  2.168918e-03  2.258746e-03  2.351809e-03
## ASV0235     -1.731069e-03 -1.807326e-03 -1.886665e-03 -1.969187e-03
## ASV0382      5.498159e-04  5.843310e-04  6.208718e-04  6.595287e-04
## ASV2357      2.600036e-03  2.714077e-03  2.832793e-03  2.956356e-03
## ASV0567     -1.767216e-03 -1.839689e-03 -1.914839e-03 -1.992758e-03
## ASV0165      2.003993e-03  2.088536e-03  2.176251e-03  2.267230e-03
## ASV0005      3.861978e-03  4.015451e-03  4.173879e-03  4.337338e-03
## ASV0384     -1.037904e-05 -9.516983e-07  9.692698e-06  2.166392e-05
## ASV0002      1.005084e-03  1.054898e-03  1.107201e-03  1.162113e-03
## ASV3017      2.195712e-03  2.280619e-03  2.368147e-03  2.458334e-03
## ASV0091      9.816589e-04  1.026761e-03  1.073826e-03  1.122928e-03
## ASV0186     -2.497902e-03 -2.606122e-03 -2.718555e-03 -2.835323e-03
## ASV0370      2.933195e-04  3.081853e-04  3.238355e-04  3.403146e-04
## ASV0018      4.057283e-03  4.220437e-03  4.389030e-03  4.563164e-03
## ASV1377      3.520460e-03  3.661678e-03  3.807658e-03  3.958501e-03
## ASV0019      4.066657e-03  4.230436e-03  4.399700e-03  4.574551e-03
## ASV0023      2.332469e-05  1.128363e-05 -2.178877e-06 -1.716687e-05
## ASV2194      1.489095e-03  1.558175e-03  1.630379e-03  1.705841e-03
## ASV1155     -1.815079e-05 -1.181696e-05 -4.692367e-06  3.282400e-06
## ASV0510     -1.236229e-03 -1.273594e-03 -1.311305e-03 -1.349308e-03
## ASV2371     -1.329819e-03 -1.377665e-03 -1.426749e-03 -1.477074e-03
## ASV0024     -1.810999e-04 -2.018767e-04 -2.244116e-04 -2.488191e-04
## ASV2452      1.774504e-03  1.838721e-03  1.904493e-03  1.971803e-03
## ASV2332      3.423437e-04  3.675215e-04  3.943806e-04  4.230129e-04
## ASV2591      3.283081e-04  3.523365e-04  3.779280e-04  4.051624e-04
## ASV0521      2.936520e-03  3.072386e-03  3.214314e-03  3.362552e-03
## ASV5542      9.542115e-04  9.993862e-04  1.046572e-03  1.095845e-03
## ASV0336     -1.248130e-03 -1.299945e-03 -1.353657e-03 -1.409321e-03
## ASV10102     1.969506e-03  2.056750e-03  2.147537e-03  2.241984e-03
## ASV16823    -1.259449e-03 -1.303614e-03 -1.348861e-03 -1.395193e-03
## ASV3104      1.258875e-03  1.303000e-03  1.348206e-03  1.394494e-03
## ASV0781      6.743724e-04  7.008764e-04  7.282259e-04  7.564365e-04
## ASV10899     9.267803e-04  9.772310e-04  1.030421e-03  1.086487e-03
## ASV11222    -1.258662e-03 -1.302783e-03 -1.347985e-03 -1.394270e-03
## ASV11327    -1.258088e-03 -1.302169e-03 -1.347330e-03 -1.393572e-03
## ASV12458    -1.257514e-03 -1.301556e-03 -1.346676e-03 -1.392874e-03
## ASV1636     -1.007267e-03 -1.041184e-03 -1.075811e-03 -1.111138e-03
## ASV1890     -1.307426e-03 -1.356499e-03 -1.407092e-03 -1.459242e-03
## ASV2898      3.016443e-03  3.135980e-03  3.259412e-03  3.386815e-03
## ASV8328      3.829240e-05  5.293678e-05  6.907685e-05  8.681869e-05
## ASV0709     -2.490094e-03 -2.589568e-03 -2.692315e-03 -2.798398e-03
## ASV0856      5.186067e-04  5.453412e-04  5.734367e-04  6.029563e-04
## ASV0909     -7.449890e-04 -7.598449e-04 -7.740500e-04 -7.875095e-04
## ASV0937     -2.100807e-03 -2.194525e-03 -2.292280e-03 -2.394239e-03
## ASV11390    -1.256390e-03 -1.300359e-03 -1.345401e-03 -1.391519e-03
## ASV11966     9.166145e-04  9.626137e-04  1.010852e-03  1.061424e-03
## ASV12990     4.157547e-04  4.333771e-04  4.516284e-04  4.705225e-04
## ASV14797     1.383095e-03  1.434621e-03  1.487582e-03  1.541991e-03
## ASV14904    -1.256403e-03 -1.300381e-03 -1.345435e-03 -1.391566e-03
## ASV15304     5.878301e-04  6.209417e-04  6.558652e-04  6.926866e-04
## ASV16696    -1.256073e-03 -1.300037e-03 -1.345076e-03 -1.391192e-03
## ASV1690      9.722893e-04  1.021873e-03  1.073844e-03  1.128295e-03
## ASV2029      3.966594e-03  4.128980e-03  4.297113e-03  4.471142e-03
## ASV2834      2.227063e-03  2.323536e-03  2.423851e-03  2.528137e-03
## ASV4003      9.098198e-04  9.616116e-04  1.016376e-03  1.074274e-03
## ASV4064      1.626682e-03  1.699439e-03  1.775188e-03  1.854026e-03
## ASV4294      7.441276e-04  7.857637e-04  8.297482e-04  8.762060e-04
## ASV4609     -8.464188e-07  1.557084e-06  4.215150e-06  7.146246e-06
## ASV6283     -1.256639e-03 -1.300676e-03 -1.345798e-03 -1.392006e-03
## ASV6491     -1.256066e-03 -1.300064e-03 -1.345144e-03 -1.391309e-03
## ASV7453      8.044052e-04  8.483121e-04  8.945744e-04  9.433043e-04
## ASV7959      3.295553e-04  3.529052e-04  3.777934e-04  4.043059e-04
## ASV8219      1.255975e-03  1.299985e-03  1.345079e-03  1.391260e-03
## ASV8547     -1.255403e-03 -1.299373e-03 -1.344426e-03 -1.390563e-03
## ASV9319      1.092793e-03  1.143346e-03  1.196144e-03  1.251281e-03
## ASV9382     -1.255182e-03 -1.299144e-03 -1.344189e-03 -1.390319e-03
## ASV11516    -1.254610e-03 -1.298533e-03 -1.343537e-03 -1.389623e-03
## ASV14377    -1.254038e-03 -1.297922e-03 -1.342885e-03 -1.388928e-03
## ASV1867      2.272229e-03  2.373238e-03  2.478407e-03  2.587880e-03
## ASV1895     -4.115238e-04 -4.254657e-04 -4.397613e-04 -4.544194e-04
## ASV3168      8.353064e-04  8.654900e-04  8.963533e-04  9.278800e-04
## ASV4449      1.665214e-03  1.728958e-03  1.794734e-03  1.862588e-03
## ASV6596      1.304928e-03  1.372225e-03  1.443014e-03  1.517469e-03
## ASV7492     -2.891168e-04 -2.900566e-04 -2.902667e-04 -2.896808e-04
## ASV9854     -6.090085e-04 -6.288527e-04 -6.490941e-04 -6.697279e-04
## ASV6296      1.253135e-03  1.296971e-03  1.341886e-03  1.387880e-03
## ASV4201      8.070375e-04  8.559639e-04  9.078284e-04  9.627914e-04
## ASV0552      3.833244e-03  4.005295e-03  4.184547e-03  4.371254e-03
## ASV3671     -1.217407e-04 -1.197166e-04 -1.172000e-04 -1.141610e-04
## ASV3529     -8.022215e-05 -7.367886e-05 -6.627749e-05 -5.796531e-05
## ASV1060      9.959456e-04  1.042952e-03  1.092196e-03  1.143789e-03
## ASV0239     -1.765173e-03 -1.825965e-03 -1.888035e-03 -1.951356e-03
## ASV5711     -1.707670e-03 -1.772362e-03 -1.839039e-03 -1.907739e-03
## ASV4152     -2.399658e-03 -2.497030e-03 -2.597830e-03 -2.702145e-03
## ASV1461      1.954176e-03  2.023596e-03  2.094667e-03  2.167380e-03
## ASV2877      1.739057e-03  1.808038e-03  1.879228e-03  1.952659e-03
## ASV0012      1.538464e-03  1.612059e-03  1.689110e-03  1.769769e-03
## ASV9823      3.872013e-04  3.981668e-04  4.091168e-04  4.200204e-04
## ASV0008      1.644575e-03  1.721823e-03  1.802616e-03  1.887107e-03
## ASV7832     -1.441326e-03 -1.498699e-03 -1.558057e-03 -1.619455e-03
## ASV1915      2.208764e-04  2.338580e-04  2.475046e-04  2.618362e-04
## ASV0055      1.041280e-03  1.084025e-03  1.128247e-03  1.173977e-03
## ASV0032      2.381670e-03  2.473792e-03  2.568769e-03  2.666647e-03
## ASV2977     -2.015075e-03 -2.096464e-03 -2.180678e-03 -2.267785e-03
## ASV0466      1.914134e-03  1.984805e-03  2.057394e-03  2.131909e-03
## ASV3866      2.346162e-03  2.450132e-03  2.558427e-03  2.671212e-03
## ASV0040      3.212254e-03  3.358878e-03  3.511881e-03  3.671513e-03
## ASV0496     -3.950890e-04 -4.230152e-04 -4.528414e-04 -4.846807e-04
## ASV0052      3.524337e-03  3.667038e-03  3.814591e-03  3.967096e-03
## ASV3828     -2.134481e-03 -2.221152e-03 -2.310970e-03 -2.404033e-03
## ASV1930      1.396123e-03  1.453869e-03  1.513603e-03  1.575359e-03
## ASV2126      2.229454e-03  2.321106e-03  2.415996e-03  2.514202e-03
## ASV0793      1.621280e-03  1.701726e-03  1.786080e-03  1.874512e-03
## ASV0299     -7.271402e-04 -7.483359e-04 -7.697529e-04 -7.913766e-04
## ASV0208      2.348719e-03  2.459601e-03  2.575624e-03  2.697014e-03
## ASV0511     -8.438270e-04 -8.646384e-04 -8.851555e-04 -9.053053e-04
## ASV1123     -1.285399e-03 -1.328881e-03 -1.373243e-03 -1.418466e-03
## ASV0099     -7.510925e-04 -7.772117e-04 -8.037340e-04 -8.306118e-04
## ASV0752     -2.756327e-04 -2.914665e-04 -3.081534e-04 -3.257305e-04
## ASV0883      8.900096e-05  9.562909e-05  1.026968e-04  1.102273e-04
## ASV0683      2.072453e-03  2.168505e-03  2.268822e-03  2.373574e-03
## ASV4117     -2.160706e-03 -2.248797e-03 -2.340083e-03 -2.434660e-03
## ASV2172      8.585029e-04  8.954525e-04  9.338537e-04  9.737552e-04
## ASV0330     -1.567540e-03 -1.635249e-03 -1.705602e-03 -1.778679e-03
## ASV0728      1.600426e-03  1.674268e-03  1.751303e-03  1.831646e-03
## ASV0499      3.144150e-03  3.291649e-03  3.445914e-03  3.607236e-03
## ASV0120     -3.149972e-03 -3.280716e-03 -3.416111e-03 -3.556264e-03
## ASV1446      8.493731e-05  8.002018e-05  7.425889e-05  6.757883e-05
## ASV17171    -2.078979e-03 -2.165136e-03 -2.254537e-03 -2.347288e-03
## ASV0533      6.998830e-04  7.342094e-04  7.702197e-04  8.079935e-04
## ASV2495     -9.560829e-04 -1.002027e-03 -1.050229e-03 -1.100801e-03
## ASV5582      5.993233e-04  6.171702e-04  6.351520e-04  6.532404e-04
## ASV1488      7.674030e-04  8.032487e-04  8.406690e-04  8.797207e-04
## ASV0682      2.181034e-03  2.282724e-03  2.389004e-03  2.500065e-03
## ASV0068     -2.949817e-04 -3.153869e-04 -3.371005e-04 -3.601886e-04
## ASV1987     -1.306692e-03 -1.372770e-03 -1.442168e-03 -1.515044e-03
## ASV0035      5.217516e-05  3.704091e-05  1.984280e-05  3.950231e-07
## ASV7192     -1.269588e-03 -1.315302e-03 -1.362166e-03 -1.410175e-03
## ASV0873      6.937922e-05  6.645507e-05  6.306956e-05  5.919476e-05
## ASV4749     -1.698746e-04 -1.914795e-04 -2.150213e-04 -2.406367e-04
## ASV2174      1.162713e-03  1.202578e-03  1.243345e-03  1.285013e-03
## ASV1476     -1.233041e-03 -1.288281e-03 -1.345933e-03 -1.406101e-03
## ASV0740     -3.140984e-03 -3.285727e-03 -3.436870e-03 -3.594670e-03
## ASV0170      6.250206e-04  6.521311e-04  6.803431e-04  7.096970e-04
## ASV2466     -2.635220e-03 -2.748133e-03 -2.865558e-03 -2.987660e-03
## ASV1709      1.975059e-03  2.055709e-03  2.139224e-03  2.225679e-03
## ASV6170     -1.958516e-03 -2.045108e-03 -2.135258e-03 -2.229089e-03
## ASV3673      2.251263e-03  2.351269e-03  2.455420e-03  2.563865e-03
## ASV1745      1.762428e-04  1.840367e-04  1.921325e-04  2.005373e-04
##                                                                    
## (Intercept) -5.981142e-04 -6.639528e-04 -7.361770e-04 -8.152903e-04
## ASV1236      1.644065e-03  1.704375e-03  1.766341e-03  1.829975e-03
## ASV0421     -2.980098e-03 -3.091501e-03 -3.206062e-03 -3.323812e-03
## ASV0691     -2.369158e-03 -2.448373e-03 -2.529266e-03 -2.611828e-03
## ASV0899      9.802714e-05  1.065667e-04  1.155679e-04  1.250346e-04
## ASV1004      3.389417e-03  3.515737e-03  3.645558e-03  3.778902e-03
## ASV1041     -2.289662e-03 -2.373970e-03 -2.460462e-03 -2.549129e-03
## ASV1058      3.170572e-03  3.290596e-03  3.414182e-03  3.541378e-03
## ASV12542     8.630754e-04  8.909971e-04  9.194432e-04  9.484064e-04
## ASV1294      3.797786e-03  3.946473e-03  4.099904e-03  4.258163e-03
## ASV13113     1.623052e-03  1.700205e-03  1.780976e-03  1.865527e-03
## ASV1318      3.215478e-03  3.336698e-03  3.461423e-03  3.589689e-03
## ASV2269     -9.584889e-04 -9.942712e-04 -1.031031e-03 -1.068770e-03
## ASV2542      2.408893e-03  2.517288e-03  2.630288e-03  2.748064e-03
## ASV2660     -1.773143e-03 -1.836202e-03 -1.900811e-03 -1.966968e-03
## ASV2737     -1.684833e-04 -1.775621e-04 -1.870472e-04 -1.969463e-04
## ASV2840      2.305429e-03  2.384340e-03  2.464901e-03  2.547080e-03
## ASV3053      1.094010e-04  1.128981e-04  1.164978e-04  1.202071e-04
## ASV3077      7.454085e-04  7.729504e-04  8.012957e-04  8.304591e-04
## ASV3134      3.210225e-03  3.360245e-03  3.517125e-03  3.681162e-03
## ASV3140      1.332480e-03  1.390223e-03  1.450194e-03  1.512457e-03
## ASV3579      7.247866e-04  7.653650e-04  8.082312e-04  8.535028e-04
## ASV6119     -9.575236e-04 -9.932478e-04 -1.029948e-03 -1.067627e-03
## ASV7557     -9.569240e-04 -9.926024e-04 -1.029254e-03 -1.066881e-03
## ASV8422      4.814050e-04  4.978667e-04  5.147393e-04  5.320288e-04
## ASV1086     -2.399628e-04 -2.482313e-04 -2.567275e-04 -2.654588e-04
## ASV1310      1.882960e-03  1.956207e-03  2.031682e-03  2.109405e-03
## ASV15750    -4.209766e-04 -4.348604e-04 -4.489615e-04 -4.632650e-04
## ASV16905    -9.567020e-04 -9.923663e-04 -1.029003e-03 -1.066615e-03
## ASV2033      2.142122e-03  2.239684e-03  2.341403e-03  2.447425e-03
## ASV2089      6.631624e-04  6.881045e-04  7.137297e-04  7.400386e-04
## ASV2127      2.656270e-03  2.758375e-03  2.863609e-03  2.972018e-03
## ASV2725      2.822805e-03  2.922641e-03  3.024884e-03  3.129526e-03
## ASV2804     -9.567355e-04 -9.924135e-04 -1.029066e-03 -1.066697e-03
## ASV3075      2.002679e-03  2.086014e-03  2.172562e-03  2.262439e-03
## ASV3327      2.054217e-03  2.146630e-03  2.242951e-03  2.343322e-03
## ASV3342      2.141172e-03  2.232976e-03  2.328334e-03  2.427356e-03
## ASV3532     -1.929530e-03 -2.012716e-03 -2.099223e-03 -2.189168e-03
## ASV3600      2.419436e-03  2.522394e-03  2.629319e-03  2.740335e-03
## ASV4013      1.897056e-03  1.971081e-03  2.047433e-03  2.126149e-03
## ASV4136      1.790124e-03  1.856352e-03  1.924470e-03  1.994501e-03
## ASV4195      9.559794e-04  9.916045e-04  1.028201e-03  1.065773e-03
## ASV4407     -9.553814e-04 -9.909608e-04 -1.027509e-03 -1.065029e-03
## ASV4717     -1.018975e-05 -1.290549e-05 -1.581344e-05 -1.891695e-05
## ASV6794      9.033828e-04  9.347130e-04  9.668653e-04  9.998554e-04
## ASV8324     -9.551103e-04 -9.906667e-04 -1.027190e-03 -1.064684e-03
## ASV8981     -1.328517e-04 -1.311757e-04 -1.288727e-04 -1.258855e-04
## ASV9859      1.029153e-03  1.083973e-03  1.141806e-03  1.202818e-03
## ASV0936     -1.544657e-03 -1.605102e-03 -1.667483e-03 -1.731835e-03
## ASV12683    -2.089327e-04 -2.188489e-04 -2.291584e-04 -2.398679e-04
## ASV1293      2.193801e-03  2.275475e-03  2.359455e-03  2.445766e-03
## ASV13055    -1.865338e-04 -1.909277e-04 -1.952177e-04 -1.993827e-04
## ASV17063    -9.545550e-04 -9.900982e-04 -1.026612e-03 -1.064099e-03
## ASV2228      9.539585e-04  9.894560e-04  1.025921e-03  1.063356e-03
## ASV2769     -7.059928e-05 -6.816532e-05 -6.528492e-05 -6.192909e-05
## ASV2803      3.950459e-04  4.076432e-04  4.204839e-04  4.335676e-04
## ASV2896      1.359628e-03  1.420545e-03  1.484190e-03  1.550693e-03
## ASV3062      5.728811e-04  6.050830e-04  6.391007e-04  6.750268e-04
## ASV3107      1.609906e-03  1.679155e-03  1.751149e-03  1.825982e-03
## ASV3265      2.838152e-03  2.942904e-03  3.050520e-03  3.161019e-03
## ASV3666     -9.310108e-05 -9.815303e-05 -1.034983e-04 -1.091547e-04
## ASV4497      6.840463e-04  7.099944e-04  7.367127e-04  7.642114e-04
## ASV6914     -3.738445e-04 -3.895893e-04 -4.059058e-04 -4.228084e-04
## ASV0576     -3.158422e-03 -3.267321e-03 -3.378758e-03 -3.492731e-03
## ASV0673      1.090896e-03  1.140826e-03  1.192769e-03  1.246775e-03
## ASV0772      1.101672e-03  1.147255e-03  1.194530e-03  1.243551e-03
## ASV0862     -6.871865e-04 -7.062535e-04 -7.253436e-04 -7.444181e-04
## ASV0898      1.079655e-03  1.131061e-03  1.184757e-03  1.240823e-03
## ASV0910      2.239770e-03  2.343966e-03  2.452764e-03  2.566339e-03
## ASV0964     -1.165141e-03 -1.205659e-03 -1.247076e-03 -1.289379e-03
## ASV10059     1.086911e-03  1.139747e-03  1.195126e-03  1.253162e-03
## ASV10263    -9.577836e-04 -9.936155e-04 -1.030443e-03 -1.068272e-03
## ASV1088      1.227792e-03  1.287697e-03  1.350544e-03  1.416475e-03
## ASV1101      1.726839e-03  1.793675e-03  1.862442e-03  1.933141e-03
## ASV1183      1.162587e-03  1.211098e-03  1.261378e-03  1.313476e-03
## ASV11956     3.305340e-04  3.397218e-04  3.489942e-04  3.583459e-04
## ASV12774    -1.947906e-04 -2.043932e-04 -2.144402e-04 -2.249484e-04
## ASV1321      6.781908e-04  7.165435e-04  7.570384e-04  7.997806e-04
## ASV13793    -9.570675e-04 -9.928444e-04 -1.029613e-03 -1.067380e-03
## ASV14482    -1.363603e-04 -1.431205e-04 -1.501423e-04 -1.574276e-04
## ASV15483     7.724176e-04  8.065756e-04  8.421327e-04  8.791360e-04
## ASV2062      4.475098e-03  4.655953e-03  4.843012e-03  5.036416e-03
## ASV2132      2.205648e-03  2.303098e-03  2.404547e-03  2.510133e-03
## ASV2413      2.757203e-03  2.863117e-03  2.972329e-03  3.084898e-03
## ASV2490      1.709355e-03  1.769731e-03  1.831566e-03  1.894857e-03
## ASV2594      1.087119e-03  1.134671e-03  1.184282e-03  1.236046e-03
## ASV2822     -9.584496e-04 -9.943597e-04 -1.031275e-03 -1.069201e-03
## ASV2863      1.639293e-03  1.700060e-03  1.762556e-03  1.826803e-03
## ASV2910      2.121012e-03  2.198761e-03  2.278639e-03  2.360664e-03
## ASV2980      7.648446e-04  7.921456e-04  8.200941e-04  8.486844e-04
## ASV3307      9.574627e-04  9.932977e-04  1.030133e-03  1.067974e-03
## ASV3474      1.845945e-03  1.932607e-03  2.023134e-03  2.117674e-03
## ASV3502      3.351802e-03  3.490061e-03  3.633341e-03  3.781786e-03
## ASV4236      1.503357e-03  1.556254e-03  1.610402e-03  1.665795e-03
## ASV4842     -5.393911e-04 -5.599360e-04 -5.810461e-04 -6.027211e-04
## ASV4894     -9.584584e-04 -9.943883e-04 -1.031327e-03 -1.069282e-03
## ASV5290      1.261987e-03  1.313150e-03  1.366023e-03  1.420635e-03
## ASV5501      2.424468e-04  2.532694e-04  2.645942e-04  2.764476e-04
## ASV5795      9.360243e-04  9.783500e-04  1.022461e-03  1.068419e-03
## ASV5987     -9.589149e-04 -9.948924e-04 -1.031884e-03 -1.069896e-03
## ASV6267     -9.583115e-04 -9.942424e-04 -1.031184e-03 -1.069143e-03
## ASV6862      1.705394e-03  1.764047e-03  1.824079e-03  1.885491e-03
## ASV7145      2.989073e-04  3.093021e-04  3.200216e-04  3.310803e-04
## ASV7673     -9.580878e-04 -9.940006e-04 -1.030923e-03 -1.068861e-03
## ASV7789      5.724007e-04  6.057699e-04  6.411084e-04  6.785235e-04
## ASV7809     -1.060668e-05 -5.625407e-06 -7.722200e-08  6.075217e-06
## ASV8002     -9.580164e-04 -9.939450e-04 -1.030887e-03 -1.068849e-03
## ASV8205      6.159583e-04  6.427385e-04  6.706329e-04  6.996855e-04
## ASV9155     -7.059423e-04 -7.315884e-04 -7.578887e-04 -7.848430e-04
## ASV9221      2.196085e-05  2.974804e-05  3.835218e-05  4.783234e-05
## ASV9311     -9.574584e-04 -9.933589e-04 -1.030273e-03 -1.068208e-03
## ASV9557     -9.568563e-04 -9.927103e-04 -1.029574e-03 -1.067456e-03
## ASV9936     -9.562549e-04 -9.920625e-04 -1.028877e-03 -1.066706e-03
## ASV1445      2.501017e-03  2.610148e-03  2.723683e-03  2.841772e-03
## ASV4232      2.270399e-03  2.377931e-03  2.490542e-03  2.608472e-03
## ASV6479      2.053054e-04  2.239878e-04  2.441275e-04  2.658187e-04
## ASV0142     -4.693559e-03 -4.864115e-03 -5.039207e-03 -5.218862e-03
## ASV0378     -1.420618e-03 -1.465222e-03 -1.510347e-03 -1.555930e-03
## ASV1122      3.302673e-03  3.445930e-03  3.594832e-03  3.749555e-03
## ASV0123     -4.583360e-03 -4.749157e-03 -4.919300e-03 -5.093809e-03
## ASV2064      3.954533e-04  4.060449e-04  4.166375e-04  4.272110e-04
## ASV4459     -5.085904e-04 -5.270165e-04 -5.459375e-04 -5.653596e-04
## ASV0448      1.196704e-03  1.259822e-03  1.326227e-03  1.396070e-03
## ASV0397      2.393148e-03  2.493595e-03  2.597764e-03  2.705759e-03
## ASV0485      3.229601e-03  3.360997e-03  3.497086e-03  3.638000e-03
## ASV1566      2.781443e-03  2.896874e-03  3.016460e-03  3.140307e-03
## ASV1365      1.824977e-03  1.901680e-03  1.981189e-03  2.063573e-03
## ASV1065      3.722774e-03  3.879454e-03  4.042015e-03  4.210631e-03
## ASV0722     -3.866401e-05 -3.911523e-05 -3.955226e-05 -3.997917e-05
## ASV12660    -1.523890e-03 -1.578514e-03 -1.634553e-03 -1.692016e-03
## ASV0223     -3.509346e-05 -3.443887e-05 -3.354650e-05 -3.238847e-05
## ASV0229      1.763929e-03  1.843123e-03  1.925687e-03  2.011748e-03
## ASV0877     -4.795579e-04 -4.932660e-04 -5.070982e-04 -5.210441e-04
## ASV0983      3.208534e-03  3.334021e-03  3.463541e-03  3.597170e-03
## ASV0626     -7.673071e-04 -7.845877e-04 -8.015640e-04 -8.181841e-04
## ASV4146     -1.579750e-04 -1.637430e-04 -1.697326e-04 -1.759615e-04
## ASV4175     -2.070534e-03 -2.156053e-03 -2.244625e-03 -2.336327e-03
## ASV2082     -3.260692e-04 -3.488126e-04 -3.731497e-04 -3.991822e-04
## ASV2272      1.598701e-03  1.670380e-03  1.745104e-03  1.822986e-03
## ASV2245     -1.845353e-03 -1.923580e-03 -2.004767e-03 -2.088999e-03
## ASV0590     -1.367608e-03 -1.436848e-03 -1.509521e-03 -1.585779e-03
## ASV0217     -9.924050e-04 -1.003336e-03 -1.012559e-03 -1.019908e-03
## ASV0416      1.343710e-03  1.384547e-03  1.425834e-03  1.467521e-03
## ASV1056      2.275826e-03  2.382098e-03  2.493006e-03  2.608711e-03
## ASV7777     -1.807412e-03 -1.883629e-03 -1.962760e-03 -2.044899e-03
## ASV0455      4.337595e-04  4.541897e-04  4.754495e-04  4.975555e-04
## ASV0604      6.175491e-04  6.529242e-04  6.902354e-04  7.295699e-04
## ASV6100     -1.689842e-03 -1.762195e-03 -1.837407e-03 -1.915581e-03
## ASV11359    -1.810558e-03 -1.883575e-03 -1.959061e-03 -2.037066e-03
## ASV6604      1.427717e-03  1.492676e-03  1.560450e-03  1.631149e-03
## ASV5004     -1.059349e-03 -1.102287e-03 -1.146741e-03 -1.192755e-03
## ASV1483     -9.973410e-04 -1.038594e-03 -1.081351e-03 -1.125653e-03
## ASV9773     -2.143898e-03 -2.234478e-03 -2.328517e-03 -2.426128e-03
## ASV4059      3.496128e-04  3.710698e-04  3.938227e-04  4.179393e-04
## ASV1193      3.440469e-03  3.582905e-03  3.730490e-03  3.883361e-03
## ASV4610     -5.711365e-05 -4.976153e-05 -4.156875e-05 -3.249137e-05
## ASV0742     -9.083658e-04 -9.295307e-04 -9.503643e-04 -9.708012e-04
## ASV1502     -1.415100e-04 -1.527637e-04 -1.647991e-04 -1.776587e-04
## ASV0195     -5.268772e-04 -5.547721e-04 -5.840688e-04 -6.148259e-04
## ASV1213      8.930939e-04  9.210518e-04  9.493640e-04  9.779973e-04
## ASV1648     -1.571783e-03 -1.637835e-03 -1.706423e-03 -1.777634e-03
## ASV6984     -1.211077e-03 -1.263714e-03 -1.318514e-03 -1.375564e-03
## ASV0396     -3.630166e-04 -3.554409e-04 -3.460707e-04 -3.347769e-04
## ASV4297      1.569351e-03  1.625883e-03  1.683898e-03  1.743404e-03
## ASV2622      3.706247e-03  3.846168e-03  3.990255e-03  4.138572e-03
## ASV3512      8.723316e-04  9.213412e-04  9.731857e-04  1.028024e-03
## ASV2411      1.555041e-03  1.627528e-03  1.703236e-03  1.782286e-03
## ASV2291     -5.085727e-04 -5.372863e-04 -5.676256e-04 -5.996737e-04
## ASV0807      1.989843e-03  2.088534e-03  2.191908e-03  2.300150e-03
## ASV1292      8.435380e-04  8.762169e-04  9.099808e-04  9.448604e-04
## ASV1035      3.350037e-04  3.458786e-04  3.570231e-04  3.684460e-04
## ASV0070     -6.106837e-04 -6.193192e-04 -6.269688e-04 -6.335135e-04
## ASV0255      3.721346e-04  3.856823e-04  3.994576e-04  4.134315e-04
## ASV0057     -3.540481e-03 -3.658992e-03 -3.779717e-03 -3.902577e-03
## ASV0077     -3.079956e-04 -3.069317e-04 -3.048261e-04 -3.015898e-04
## ASV0625      3.711126e-03  3.845856e-03  3.984106e-03  4.125886e-03
## ASV2464      1.724928e-03  1.785154e-03  1.846846e-03  1.910008e-03
## ASV1315      3.960958e-03  4.142144e-03  4.331170e-03  4.528333e-03
## ASV2673      2.967329e-03  3.107710e-03  3.254596e-03  3.408274e-03
## ASV2161      1.245030e-03  1.304926e-03  1.367665e-03  1.433374e-03
## ASV0337     -1.662070e-03 -1.727471e-03 -1.794949e-03 -1.864540e-03
## ASV7680     -2.082801e-03 -2.171660e-03 -2.263956e-03 -2.359799e-03
## ASV0611      4.751804e-03  4.965974e-03  5.189368e-03  5.422353e-03
## ASV3118     -1.584320e-03 -1.653757e-03 -1.725992e-03 -1.801119e-03
## ASV1284      1.669649e-03  1.742994e-03  1.819326e-03  1.898746e-03
## ASV0889      1.165293e-03  1.212417e-03  1.261239e-03  1.311811e-03
## ASV4649     -1.263222e-03 -1.315676e-03 -1.370050e-03 -1.426398e-03
## ASV1108     -1.852726e-03 -1.941144e-03 -2.033684e-03 -2.130523e-03
## ASV0738      2.944910e-04  3.317685e-04  3.722658e-04  4.161961e-04
## ASV0473      2.712746e-04  2.840456e-04  2.974273e-04  3.114482e-04
## ASV0598     -1.523854e-03 -1.573462e-03 -1.623928e-03 -1.675218e-03
## ASV0429      2.797641e-03  2.907303e-03  3.020438e-03  3.137102e-03
## ASV1549      3.337435e-03  3.496123e-03  3.662152e-03  3.835834e-03
## ASV1203      2.163829e-03  2.251271e-03  2.341696e-03  2.435169e-03
## ASV4532      4.208855e-05  4.242010e-05  4.276548e-05  4.313738e-05
## ASV0274     -1.877714e-03 -1.940762e-03 -2.005100e-03 -2.070708e-03
## ASV0163     -2.636489e-03 -2.722562e-03 -2.810177e-03 -2.899288e-03
## ASV1298      1.083912e-03  1.120885e-03  1.158756e-03  1.197538e-03
## ASV9424     -2.828874e-03 -2.952990e-03 -3.082190e-03 -3.216659e-03
## ASV0412      4.030945e-03  4.193052e-03  4.360710e-03  4.534049e-03
## ASV0284      1.611505e-03  1.667534e-03  1.724840e-03  1.783409e-03
## ASV0620     -1.593926e-03 -1.669121e-03 -1.747675e-03 -1.829716e-03
## ASV0153     -3.148231e-03 -3.290632e-03 -3.439037e-03 -3.593656e-03
## ASV0498      6.999989e-04  7.451888e-04  7.930350e-04  8.436526e-04
## ASV0097      2.329361e-03  2.439167e-03  2.554037e-03  2.674189e-03
## ASV0104     -9.444008e-03 -9.830227e-03 -1.023004e-02 -1.064378e-02
## ASV1282      1.727780e-03  1.801825e-03  1.878663e-03  1.958367e-03
## ASV3883     -1.081525e-03 -1.131121e-03 -1.182795e-03 -1.236608e-03
## ASV0801      1.157696e-03  1.214365e-03  1.273719e-03  1.335871e-03
## ASV1611     -3.857077e-03 -4.025763e-03 -4.201271e-03 -4.383834e-03
## ASV0227     -1.628321e-03 -1.709009e-03 -1.793572e-03 -1.882175e-03
## ASV0833      1.730196e-03  1.814654e-03  1.903030e-03  1.995479e-03
## ASV0718      3.483184e-03  3.630377e-03  3.783105e-03  3.941524e-03
## ASV1139      9.229865e-04  9.453216e-04  9.672495e-04  9.886751e-04
## ASV0766     -8.428621e-04 -8.735409e-04 -9.050372e-04 -9.373576e-04
## ASV2091      4.097464e-03  4.245201e-03  4.396768e-03  4.552178e-03
## ASV1238     -1.305382e-05 -9.530732e-07  1.248478e-05  2.734893e-05
## ASV9193     -6.458020e-04 -6.829421e-04 -7.221535e-04 -7.635337e-04
## ASV0290     -5.280999e-04 -5.552226e-04 -5.835537e-04 -6.131185e-04
## ASV0231      3.571395e-03  3.716895e-03  3.867499e-03  4.023330e-03
## ASV0185      1.508737e-03  1.612811e-03  1.723888e-03  1.842388e-03
## ASV2330      9.543487e-04  9.897717e-04  1.026209e-03  1.063676e-03
## ASV3119     -1.549621e-03 -1.630786e-03 -1.716181e-03 -1.806007e-03
## ASV2368     -1.858616e-03 -1.946276e-03 -2.038030e-03 -2.134065e-03
## ASV0122     -1.129046e-03 -1.168225e-03 -1.208320e-03 -1.249329e-03
## ASV1044      2.678626e-03  2.808799e-03  2.945137e-03  3.087904e-03
## ASV0160     -2.656689e-03 -2.741327e-03 -2.827255e-03 -2.914405e-03
## ASV0326      2.117386e-03  2.206114e-03  2.298073e-03  2.393341e-03
## ASV1388      3.626337e-03  3.775567e-03  3.930166e-03  4.090281e-03
## ASV0792      3.903301e-03  4.053486e-03  4.208206e-03  4.367517e-03
## ASV0036     -2.788835e-03 -2.911850e-03 -3.039781e-03 -3.172776e-03
## ASV2125      4.226527e-03  4.399298e-03  4.578117e-03  4.763123e-03
## ASV1075      9.317673e-04  9.760904e-04  1.022468e-03  1.070988e-03
## ASV0390      1.100461e-03  1.161364e-03  1.225744e-03  1.293795e-03
## ASV3790     -3.566355e-03 -3.720579e-03 -3.880889e-03 -4.047485e-03
## ASV1535     -4.055702e-04 -4.286597e-04 -4.530783e-04 -4.788954e-04
## ASV0263      7.252459e-04  7.560818e-04  7.881010e-04  8.213411e-04
## ASV0675      6.209350e-03  6.494279e-03  6.791663e-03  7.101982e-03
## ASV3348      6.864365e-04  7.221451e-04  7.597281e-04  7.992793e-04
## ASV0058     -5.235973e-03 -5.444903e-03 -5.660704e-03 -5.883500e-03
## ASV4142      1.278240e-03  1.327243e-03  1.377711e-03  1.429663e-03
## ASV0059     -4.472232e-03 -4.648395e-03 -4.830153e-03 -5.017590e-03
## ASV0013     -9.587080e-03 -9.979646e-03 -1.038611e-02 -1.080683e-02
## ASV0033     -3.066013e-03 -3.202962e-03 -3.345550e-03 -3.493963e-03
## ASV4354     -1.143523e-03 -1.187503e-03 -1.232925e-03 -1.279826e-03
## ASV0022     -3.206559e-03 -3.348245e-03 -3.495626e-03 -3.648877e-03
## ASV0134     -9.138007e-04 -9.593219e-04 -1.007062e-03 -1.057123e-03
## ASV0415     -3.204624e-04 -3.206797e-04 -3.200577e-04 -3.185307e-04
## ASV10103    -2.184935e-03 -2.279269e-03 -2.377293e-03 -2.479122e-03
## ASV1613      3.189205e-03  3.310831e-03  3.436018e-03  3.564794e-03
## ASV0135      2.510996e-04  2.826206e-04  3.169340e-04  3.542345e-04
## ASV0469     -3.959323e-03 -4.111208e-03 -4.267810e-03 -4.429215e-03
## ASV0471      2.743680e-03  2.859695e-03  2.980120e-03  3.105096e-03
## ASV0451     -9.358065e-04 -9.839172e-04 -1.034455e-03 -1.087529e-03
## ASV0747      1.267944e-03  1.330217e-03  1.395404e-03  1.463617e-03
## ASV1314     -1.919399e-03 -2.015287e-03 -2.116035e-03 -2.221886e-03
## ASV0425     -4.250747e-03 -4.400965e-03 -4.554779e-03 -4.712171e-03
## ASV0559     -2.450726e-03 -2.541481e-03 -2.635004e-03 -2.731368e-03
## ASV0148     -2.550998e-03 -2.636586e-03 -2.723741e-03 -2.812397e-03
## ASV0129     -1.011094e-03 -1.030677e-03 -1.049266e-03 -1.066716e-03
## ASV1072      1.194519e-03  1.232084e-03  1.270102e-03  1.308526e-03
## ASV2390      8.467445e-04  8.727364e-04  8.989480e-04  9.253327e-04
## ASV0548      3.213613e-03  3.351975e-03  3.495742e-03  3.645085e-03
## ASV0168     -4.443609e-03 -4.617738e-03 -4.797541e-03 -4.983141e-03
## ASV0066     -3.354442e-03 -3.487519e-03 -3.624911e-03 -3.766692e-03
## ASV0468     -1.292318e-03 -1.346832e-03 -1.403449e-03 -1.462242e-03
## ASV0172     -2.916755e-04 -2.834126e-04 -2.733490e-04 -2.613376e-04
## ASV0236     -1.203577e-03 -1.225759e-03 -1.246740e-03 -1.266362e-03
## ASV0250      7.869131e-04  8.530590e-04  9.241940e-04  1.000637e-03
## ASV0338      7.922338e-05  9.623166e-05  1.146949e-04  1.346881e-04
## ASV0450     -1.012764e-05 -1.046627e-05 -1.084942e-05 -1.128744e-05
## ASV0377      3.799168e-03  3.955988e-03  4.118414e-03  4.286582e-03
## ASV1022      1.103675e-03  1.152147e-03  1.202651e-03  1.255269e-03
## ASV6174     -2.395944e-04 -2.491608e-04 -2.591023e-04 -2.694354e-04
## ASV0786      3.316656e-04  3.414345e-04  3.513000e-04  3.612512e-04
## ASV0053     -4.619541e-03 -4.812473e-03 -5.012483e-03 -5.219762e-03
## ASV0697     -1.095223e-03 -1.130273e-03 -1.165872e-03 -1.201993e-03
## ASV0785      3.419796e-03  3.561929e-03  3.709261e-03  3.861938e-03
## ASV1967     -2.002481e-03 -2.075183e-03 -2.149872e-03 -2.226567e-03
## ASV0385     -8.387950e-04 -8.641470e-04 -8.897840e-04 -9.156794e-04
## ASV0295      3.854563e-04  4.199829e-04  4.572299e-04  4.973786e-04
## ASV0072     -3.248560e-03 -3.363130e-03 -3.480284e-03 -3.599975e-03
## ASV0157     -1.153590e-03 -1.182571e-03 -1.211024e-03 -1.238807e-03
## ASV0501      1.938042e-03  2.031216e-03  2.128721e-03  2.230736e-03
## ASV10729    -2.890760e-03 -3.014884e-03 -3.143801e-03 -3.277652e-03
## ASV1470      1.211408e-03  1.255902e-03  1.301559e-03  1.348376e-03
## ASV0050     -8.840040e-03 -9.191395e-03 -9.554339e-03 -9.929101e-03
## ASV0411     -6.400843e-05 -5.843353e-05 -5.204879e-05 -4.479487e-05
## ASV0549      1.984057e-03  2.078556e-03  2.177455e-03  2.280944e-03
## ASV0184      1.083644e-03  1.130303e-03  1.178881e-03  1.229453e-03
## ASV0705      1.383518e-03  1.444335e-03  1.507512e-03  1.573109e-03
## ASV1715      3.321236e-03  3.462668e-03  3.609543e-03  3.762030e-03
## ASV0603      4.615746e-04  4.852521e-04  5.102384e-04  5.366135e-04
## ASV0826      9.475051e-04  9.803022e-04  1.013823e-03  1.048059e-03
## ASV0034     -3.832412e-03 -3.975942e-03 -4.123445e-03 -4.274935e-03
## ASV0838      8.085363e-04  8.378872e-04  8.678738e-04  8.984689e-04
## ASV0614     -2.230908e-03 -2.317651e-03 -2.407088e-03 -2.499254e-03
## ASV0014     -8.614534e-03 -8.959523e-03 -9.316132e-03 -9.684611e-03
## ASV0585     -5.895036e-04 -6.150566e-04 -6.415723e-04 -6.690716e-04
## ASV0016     -8.826025e-03 -9.180436e-03 -9.546859e-03 -9.925557e-03
## ASV5394     -2.359183e-03 -2.459225e-03 -2.563005e-03 -2.670622e-03
## ASV0666      1.888762e-03  1.963648e-03  2.040970e-03  2.120772e-03
## ASV2085      3.747912e-04  3.730007e-04  3.699721e-04  3.656061e-04
## ASV0003     -7.992072e-03 -8.309227e-03 -8.636854e-03 -8.975166e-03
## ASV0346      2.492628e-04  2.775853e-04  3.081662e-04  3.411354e-04
## ASV0267     -1.036817e-03 -1.066580e-03 -1.096457e-03 -1.126393e-03
## ASV0353      2.204078e-03  2.316056e-03  2.433651e-03  2.557120e-03
## ASV2419      2.216951e-03  2.303512e-03  2.392868e-03  2.485075e-03
## ASV0447      1.558455e-03  1.642772e-03  1.731501e-03  1.824837e-03
## ASV0654      3.798403e-03  3.962305e-03  4.132468e-03  4.309057e-03
## ASV0151      8.899368e-04  9.433541e-04  1.000052e-03  1.060219e-03
## ASV0065     -3.257486e-03 -3.387508e-03 -3.521801e-03 -3.660442e-03
## ASV0527      2.383494e-03  2.480315e-03  2.580488e-03  2.684088e-03
## ASV4055     -1.063029e-03 -1.115466e-03 -1.170549e-03 -1.228417e-03
## ASV0166     -2.504467e-03 -2.595422e-03 -2.688767e-03 -2.784512e-03
## ASV0417     -2.236721e-03 -2.324409e-03 -2.414965e-03 -2.508451e-03
## ASV0078     -1.653404e-03 -1.709518e-03 -1.766607e-03 -1.824608e-03
## ASV0322     -2.023622e-03 -2.093820e-03 -2.165485e-03 -2.238576e-03
## ASV0156     -2.798650e-03 -2.906710e-03 -3.018178e-03 -3.133120e-03
## ASV0648     -2.861249e-03 -2.987538e-03 -3.118987e-03 -3.255774e-03
## ASV0407      3.342704e-04  3.542683e-04  3.754681e-04  3.979360e-04
## ASV2030     -4.517018e-04 -4.666638e-04 -4.820703e-04 -4.979464e-04
## ASV0300      1.916916e-03  2.011634e-03  2.110867e-03  2.214802e-03
## ASV1150     -7.224168e-05 -6.871561e-05 -6.454886e-05 -5.968754e-05
## ASV0958      2.031037e-03  2.134824e-03  2.244024e-03  2.358919e-03
## ASV0216     -2.533281e-03 -2.626140e-03 -2.721696e-03 -2.820005e-03
## ASV0446      4.418879e-03  4.622765e-03  4.835486e-03  5.057362e-03
## ASV0367     -1.322891e-03 -1.376530e-03 -1.432056e-03 -1.489518e-03
## ASV0200     -2.551789e-03 -2.659572e-03 -2.771479e-03 -2.887641e-03
## ASV0334     -8.062273e-04 -8.181001e-04 -8.289799e-04 -8.387665e-04
## ASV1311      1.683698e-03  1.748675e-03  1.815620e-03  1.884558e-03
## ASV0458      1.885899e-03  1.963185e-03  2.043274e-03  2.126244e-03
## ASV1371      7.845109e-05  8.258797e-05  8.693061e-05  9.148647e-05
## ASV0418      2.373049e-03  2.473347e-03  2.577509e-03  2.685663e-03
## ASV0004      2.758949e-03  2.871948e-03  2.988950e-03  3.110056e-03
## ASV1943      1.915449e-03  1.990441e-03  2.067912e-03  2.147916e-03
## ASV1495     -7.925927e-04 -8.395911e-04 -8.894055e-04 -9.421934e-04
## ASV0901     -3.449421e-03 -3.606152e-03 -3.769697e-03 -3.940328e-03
## ASV0628      1.683281e-03  1.744056e-03  1.806269e-03  1.869895e-03
## ASV0400      6.759900e-04  7.002712e-04  7.250931e-04  7.504383e-04
## ASV0116     -2.780060e-03 -2.911403e-03 -3.048768e-03 -3.192407e-03
## ASV0788      2.049727e-03  2.136194e-03  2.225899e-03  2.318932e-03
## ASV0117      1.562303e-03  1.640018e-03  1.721579e-03  1.807165e-03
## ASV3137      3.274776e-04  3.399135e-04  3.527346e-04  3.659499e-04
## ASV0001      2.965088e-03  3.070459e-03  3.178375e-03  3.288821e-03
## ASV1651      1.996225e-03  2.069285e-03  2.144409e-03  2.221630e-03
## ASV1692      2.688823e-03  2.814721e-03  2.946282e-03  3.083733e-03
## ASV0660      1.057782e-03  1.085855e-03  1.113637e-03  1.141017e-03
## ASV0508      7.470156e-05  7.439440e-05  7.389972e-05  7.320752e-05
## ASV1660     -1.157361e-03 -1.212790e-03 -1.270705e-03 -1.331195e-03
## ASV0233      6.759361e-04  7.108797e-04  7.476851e-04  7.864513e-04
## ASV1343     -2.507863e-03 -2.617371e-03 -2.731320e-03 -2.849866e-03
## ASV0209      1.930369e-03  1.997843e-03  2.066928e-03  2.137623e-03
## ASV0193     -2.652251e-03 -2.751925e-03 -2.854531e-03 -2.960113e-03
## ASV0357      1.224332e-04  1.423699e-04  1.642684e-04  1.882809e-04
## ASV0198      6.603257e-04  6.901441e-04  7.212905e-04  7.538264e-04
## ASV0007      2.811018e-03  2.910953e-03  3.013306e-03  3.118065e-03
## ASV1772     -2.821508e-04 -2.908285e-04 -2.994768e-04 -3.080545e-04
## ASV0009      2.628784e-03  2.721103e-03  2.815565e-03  2.912150e-03
## ASV0006      8.174356e-04  8.337628e-04  8.494235e-04  8.643223e-04
## ASV0011     -3.565226e-03 -3.723214e-03 -3.887726e-03 -4.058996e-03
## ASV0015      2.326499e-03  2.421721e-03  2.520272e-03  2.622226e-03
## ASV0017      2.448191e-03  2.547975e-03  2.651242e-03  2.758075e-03
## ASV0235     -2.054996e-03 -2.144196e-03 -2.236896e-03 -2.333203e-03
## ASV0382      7.003924e-04  7.435536e-04  7.891022e-04  8.371270e-04
## ASV2357      3.084941e-03  3.218732e-03  3.357914e-03  3.502682e-03
## ASV0567     -2.073537e-03 -2.157274e-03 -2.244071e-03 -2.334034e-03
## ASV0165      2.361564e-03  2.459347e-03  2.560674e-03  2.665637e-03
## ASV0005      4.505901e-03  4.679635e-03  4.858602e-03  5.042858e-03
## ASV0384      3.507965e-05  5.006589e-05  6.675743e-05  8.529831e-05
## ASV0002      1.219761e-03  1.280277e-03  1.343796e-03  1.410461e-03
## ASV3017      2.551220e-03  2.646843e-03  2.745240e-03  2.846445e-03
## ASV0091      1.174140e-03  1.227540e-03  1.283203e-03  1.341210e-03
## ASV0186     -2.956551e-03 -3.082358e-03 -3.212867e-03 -3.348198e-03
## ASV0370      3.576699e-04  3.759520e-04  3.952146e-04  4.155149e-04
## ASV0018      4.742934e-03  4.928435e-03  5.119755e-03  5.316978e-03
## ASV1377      4.114310e-03  4.275184e-03  4.441222e-03  4.612524e-03
## ASV0019      4.755092e-03  4.941418e-03  5.133624e-03  5.331797e-03
## ASV0023     -3.378875e-05 -5.215715e-05 -7.238884e-05 -9.460448e-05
## ASV2194      1.784699e-03  1.867096e-03  1.953181e-03  2.043107e-03
## ASV1155      1.216917e-05  2.203209e-05  3.293754e-05  4.495403e-05
## ASV0510     -1.387549e-03 -1.425971e-03 -1.464513e-03 -1.503113e-03
## ASV2371     -1.528641e-03 -1.581448e-03 -1.635493e-03 -1.690772e-03
## ASV0024     -2.752182e-04 -3.037323e-04 -3.344891e-04 -3.676205e-04
## ASV2452      2.040629e-03  2.110948e-03  2.182728e-03  2.255937e-03
## ASV2332      4.535139e-04  4.859816e-04  5.205176e-04  5.572258e-04
## ASV2591      4.341213e-04  4.648882e-04  4.975483e-04  5.321883e-04
## ASV0521      3.517356e-03  3.678991e-03  3.847728e-03  4.023847e-03
## ASV5542      1.147282e-03  1.200961e-03  1.256964e-03  1.315372e-03
## ASV0336     -1.466992e-03 -1.526726e-03 -1.588582e-03 -1.652619e-03
## ASV10102     2.340207e-03  2.442323e-03  2.548451e-03  2.658709e-03
## ASV16823    -1.442610e-03 -1.491111e-03 -1.540693e-03 -1.591355e-03
## ASV3104      1.441865e-03  1.490317e-03  1.539849e-03  1.590458e-03
## ASV0781      7.855243e-04  8.155055e-04  8.463966e-04  8.782147e-04
## ASV10899     1.145573e-03  1.207824e-03  1.273396e-03  1.342445e-03
## ASV11222    -1.441640e-03 -1.490092e-03 -1.539626e-03 -1.590238e-03
## ASV11327    -1.440895e-03 -1.489299e-03 -1.538782e-03 -1.589342e-03
## ASV12458    -1.440152e-03 -1.488508e-03 -1.537940e-03 -1.588446e-03
## ASV1636     -1.147158e-03 -1.183859e-03 -1.221231e-03 -1.259263e-03
## ASV1890     -1.512985e-03 -1.568362e-03 -1.625414e-03 -1.684182e-03
## ASV2898      3.518259e-03  3.653814e-03  3.793550e-03  3.937534e-03
## ASV8328      1.062735e-04  1.275579e-04  1.507934e-04  1.761074e-04
## ASV0709     -2.907875e-03 -3.020804e-03 -3.137241e-03 -3.257239e-03
## ASV0856      6.339653e-04  6.665311e-04  7.007231e-04  7.366127e-04
## ASV0909     -8.001234e-04 -8.117872e-04 -8.223914e-04 -8.318218e-04
## ASV0937     -2.500577e-03 -2.611476e-03 -2.727124e-03 -2.847718e-03
## ASV11390    -1.438713e-03 -1.486980e-03 -1.536320e-03 -1.586730e-03
## ASV11966     1.114429e-03  1.169968e-03  1.228145e-03  1.289065e-03
## ASV12990     4.900738e-04  5.102963e-04  5.312046e-04  5.528132e-04
## ASV14797     1.597858e-03  1.655193e-03  1.714007e-03  1.774309e-03
## ASV14904    -1.438773e-03 -1.487057e-03 -1.536416e-03 -1.586846e-03
## ASV15304     7.314943e-04  7.723793e-04  8.154348e-04  8.607566e-04
## ASV16696    -1.438385e-03 -1.486655e-03 -1.536001e-03 -1.586419e-03
## ASV1690      1.185317e-03  1.245003e-03  1.307449e-03  1.372746e-03
## ASV2029      4.651212e-03  4.837472e-03  5.030070e-03  5.229157e-03
## ASV2834      2.636524e-03  2.749145e-03  2.866138e-03  2.987639e-03
## ASV4003      1.135476e-03  1.200159e-03  1.268507e-03  1.340714e-03
## ASV4064      1.936055e-03  2.021376e-03  2.110093e-03  2.202310e-03
## ASV4294      9.252673e-04  9.770681e-04  1.031750e-03  1.089461e-03
## ASV4609      1.036993e-05  1.390692e-05  1.777910e-05  2.200963e-05
## ASV6283     -1.439301e-03 -1.487684e-03 -1.537155e-03 -1.587711e-03
## ASV6491     -1.438558e-03 -1.486893e-03 -1.536312e-03 -1.586815e-03
## ASV7453      9.946175e-04  1.048633e-03  1.105474e-03  1.165265e-03
## ASV7959      4.325321e-04  4.625647e-04  4.944999e-04  5.284374e-04
## ASV8219      1.438529e-03  1.486887e-03  1.536335e-03  1.586870e-03
## ASV8547     -1.437786e-03 -1.486096e-03 -1.535493e-03 -1.585975e-03
## ASV9319      1.308854e-03  1.368964e-03  1.431715e-03  1.497216e-03
## ASV9382     -1.437537e-03 -1.485841e-03 -1.535234e-03 -1.585713e-03
## ASV11516    -1.436795e-03 -1.485051e-03 -1.534393e-03 -1.584819e-03
## ASV14377    -1.436053e-03 -1.484262e-03 -1.533553e-03 -1.583926e-03
## ASV1867      2.701805e-03  2.820331e-03  2.943612e-03  3.071803e-03
## ASV1895     -4.694501e-04 -4.848644e-04 -5.006750e-04 -5.168958e-04
## ASV3168      9.600516e-04  9.928466e-04  1.026241e-03  1.060209e-03
## ASV4449      1.932567e-03  2.004721e-03  2.079099e-03  2.155753e-03
## ASV6596      1.595772e-03  1.678111e-03  1.764681e-03  1.855686e-03
## ASV7492     -2.882301e-04 -2.858427e-04 -2.824438e-04 -2.779558e-04
## ASV9854     -6.907491e-04 -7.121519e-04 -7.339298e-04 -7.560760e-04
## ASV6296      1.434956e-03  1.483114e-03  1.532354e-03  1.582676e-03
## ASV4201      1.021020e-03  1.082690e-03  1.147981e-03  1.217083e-03
## ASV0552      4.565671e-03  4.768060e-03  4.978684e-03  5.197812e-03
## ASV3671     -1.105698e-04 -1.063969e-04 -1.016129e-04 -9.618944e-05
## ASV3529     -4.868868e-05 -3.839321e-05 -2.702395e-05 -1.452562e-05
## ASV1060      1.197846e-03  1.254490e-03  1.313849e-03  1.376059e-03
## ASV0239     -2.015896e-03 -2.081621e-03 -2.148492e-03 -2.216466e-03
## ASV5711     -1.978499e-03 -2.051354e-03 -2.126343e-03 -2.203502e-03
## ASV4152     -2.810064e-03 -2.921675e-03 -3.037067e-03 -3.156327e-03
## ASV1461      2.241720e-03  2.317672e-03  2.395216e-03  2.474332e-03
## ASV2877      2.028362e-03  2.106366e-03  2.186696e-03  2.269376e-03
## ASV0012      1.854191e-03  1.942538e-03  2.034978e-03  2.131683e-03
## ASV9823      4.308446e-04  4.415541e-04  4.521115e-04  4.624775e-04
## ASV0008      1.975451e-03  2.067813e-03  2.164361e-03  2.265268e-03
## ASV7832     -1.682945e-03 -1.748584e-03 -1.816427e-03 -1.886531e-03
## ASV1915      2.768723e-04  2.926308e-04  3.091286e-04  3.263808e-04
## ASV0055      1.221240e-03  1.270063e-03  1.320470e-03  1.372483e-03
## ASV0032      2.767471e-03  2.871286e-03  2.978133e-03  3.088055e-03
## ASV2977     -2.357853e-03 -2.450950e-03 -2.547142e-03 -2.646496e-03
## ASV0466      2.208351e-03  2.286724e-03  2.367023e-03  2.449243e-03
## ASV3866      2.788652e-03  2.910923e-03  3.038204e-03  3.170680e-03
## ASV0040      3.838027e-03  4.011687e-03  4.192760e-03  4.381523e-03
## ASV0496     -5.186507e-04 -5.548739e-04 -5.934774e-04 -6.345933e-04
## ASV0052      4.124651e-03  4.287350e-03  4.455287e-03  4.628550e-03
## ASV3828     -2.500443e-03 -2.600305e-03 -2.703729e-03 -2.810827e-03
## ASV1930      1.639172e-03  1.705073e-03  1.773094e-03  1.843261e-03
## ASV2126      2.615802e-03  2.720875e-03  2.829498e-03  2.941748e-03
## ASV0793      1.967199e-03  2.064321e-03  2.166064e-03  2.272617e-03
## ASV0299     -8.131939e-04 -8.351927e-04 -8.573629e-04 -8.796965e-04
## ASV0208      2.824009e-03  2.956854e-03  3.095803e-03  3.241120e-03
## ASV0511     -9.250113e-04 -9.441942e-04 -9.627717e-04 -9.806590e-04
## ASV1123     -1.464530e-03 -1.511411e-03 -1.559084e-03 -1.607521e-03
## ASV0099     -8.577910e-04 -8.852103e-04 -9.128007e-04 -9.404853e-04
## ASV0752     -3.442358e-04 -3.637081e-04 -3.841868e-04 -4.057119e-04
## ASV0883      1.182444e-04  1.267726e-04  1.358369e-04  1.454629e-04
## ASV0683      2.482938e-03  2.597093e-03  2.716226e-03  2.840526e-03
## ASV4117     -2.532627e-03 -2.634085e-03 -2.739137e-03 -2.847887e-03
## ASV2172      1.015207e-03  1.058262e-03  1.102973e-03  1.149394e-03
## ASV0330     -1.854566e-03 -1.933346e-03 -2.015105e-03 -2.099930e-03
## ASV0728      1.915416e-03  2.002735e-03  2.093727e-03  2.188519e-03
## ASV0499      3.775920e-03  3.952279e-03  4.136639e-03  4.329335e-03
## ASV0120     -3.701280e-03 -3.851259e-03 -4.006303e-03 -4.166508e-03
## ASV1446      5.990045e-05  5.113899e-05  4.120420e-05  3.000010e-05
## ASV17171    -2.443501e-03 -2.543290e-03 -2.646772e-03 -2.754067e-03
## ASV0533      8.476137e-04  8.891667e-04  9.327422e-04  9.784331e-04
## ASV2495     -1.153861e-03 -1.209529e-03 -1.267934e-03 -1.329206e-03
## ASV5582      6.714053e-04  6.896149e-04  7.078359e-04  7.260329e-04
## ASV1488      9.204610e-04  9.629480e-04  1.007240e-03  1.053396e-03
## ASV0682      2.616103e-03  2.737319e-03  2.863923e-03  2.996127e-03
## ASV0068     -3.847183e-04 -4.107574e-04 -4.383747e-04 -4.676388e-04
## ASV1987     -1.591562e-03 -1.671891e-03 -1.756207e-03 -1.844695e-03
## ASV0035     -2.150107e-05 -4.605762e-05 -7.350084e-05 -1.040717e-04
## ASV7192     -1.459319e-03 -1.509590e-03 -1.560972e-03 -1.613451e-03
## ASV0873      5.480248e-05  4.986441e-05  4.435227e-05  3.823796e-05
## ASV4749     -2.684687e-04 -2.986675e-04 -3.313903e-04 -3.668012e-04
## ASV2174      1.327581e-03  1.371050e-03  1.415420e-03  1.460693e-03
## ASV1476     -1.468888e-03 -1.534405e-03 -1.602765e-03 -1.674083e-03
## ASV0740     -3.759389e-03 -3.931301e-03 -4.110685e-03 -4.297828e-03
## ASV0170      7.402344e-04  7.719984e-04  8.050333e-04  8.393846e-04
## ASV2466     -3.114609e-03 -3.246580e-03 -3.383755e-03 -3.526321e-03
## ASV1709      2.315148e-03  2.407706e-03  2.503426e-03  2.602383e-03
## ASV6170     -2.326729e-03 -2.428308e-03 -2.533958e-03 -2.643813e-03
## ASV3673      2.676753e-03  2.794240e-03  2.916482e-03  3.043641e-03
## ASV1745      2.092579e-04  2.183006e-04  2.276715e-04  2.373758e-04
##                                                                    
## (Intercept) -9.018224e-04 -9.963290e-04 -1.099392e-03 -1.211618e-03
## ASV1236      1.895293e-03  1.962304e-03  2.031021e-03  2.101452e-03
## ASV0421     -3.444779e-03 -3.568987e-03 -3.696460e-03 -3.827219e-03
## ASV0691     -2.696046e-03 -2.781909e-03 -2.869406e-03 -2.958523e-03
## ASV0899      1.349685e-04  1.453688e-04  1.562325e-04  1.675536e-04
## ASV1004      3.915784e-03  4.056216e-03  4.200205e-03  4.347754e-03
## ASV1041     -2.639961e-03 -2.732940e-03 -2.828045e-03 -2.925249e-03
## ASV1058      3.672234e-03  3.806798e-03  3.945114e-03  4.087229e-03
## ASV12542     9.778794e-04  1.007855e-03  1.038326e-03  1.069286e-03
## ASV1294      4.421333e-03  4.589496e-03  4.762732e-03  4.941117e-03
## ASV13113     1.954027e-03  2.046650e-03  2.143576e-03  2.244996e-03
## ASV1318      3.721529e-03  3.856974e-03  3.996052e-03  4.138788e-03
## ASV2269     -1.107491e-03 -1.147193e-03 -1.187874e-03 -1.229530e-03
## ASV2542      2.870794e-03  2.998660e-03  3.131850e-03  3.270553e-03
## ASV2660     -2.034670e-03 -2.103912e-03 -2.174686e-03 -2.246983e-03
## ASV2737     -2.072663e-04 -2.180126e-04 -2.291897e-04 -2.408005e-04
## ASV2840      2.630841e-03  2.716145e-03  2.802948e-03  2.891204e-03
## ASV3053      1.240339e-04  1.279875e-04  1.320781e-04  1.363172e-04
## ASV3077      8.604560e-04  8.913020e-04  9.230138e-04  9.556085e-04
## ASV3134      3.852666e-03  4.031959e-03  4.219371e-03  4.415250e-03
## ASV3140      1.577075e-03  1.644112e-03  1.713631e-03  1.785696e-03
## ASV3579      9.013019e-04  9.517543e-04  1.004990e-03  1.061143e-03
## ASV6119     -1.106287e-03 -1.145927e-03 -1.186546e-03 -1.228141e-03
## ASV7557     -1.105485e-03 -1.145066e-03 -1.185622e-03 -1.227151e-03
## ASV8422      5.497420e-04  5.678862e-04  5.864692e-04  6.054998e-04
## ASV1086     -2.744331e-04 -2.836594e-04 -2.931476e-04 -3.029086e-04
## ASV1310      2.189395e-03  2.271667e-03  2.356231e-03  2.443095e-03
## ASV15750    -4.777550e-04 -4.924140e-04 -5.072230e-04 -5.221615e-04
## ASV16905    -1.105204e-03 -1.144770e-03 -1.185312e-03 -1.226826e-03
## ASV2033      2.557900e-03  2.672977e-03  2.792811e-03  2.917556e-03
## ASV2089      7.670308e-04  7.947041e-04  8.230555e-04  8.520802e-04
## ASV2127      3.083649e-03  3.198547e-03  3.316753e-03  3.438310e-03
## ASV2725      3.236554e-03  3.345953e-03  3.457705e-03  3.571787e-03
## ASV2804     -1.105308e-03 -1.144899e-03 -1.185470e-03 -1.227017e-03
## ASV3075      2.355769e-03  2.452679e-03  2.553303e-03  2.657778e-03
## ASV3327      2.447890e-03  2.556802e-03  2.670211e-03  2.788273e-03
## ASV3342      2.530155e-03  2.636843e-03  2.747537e-03  2.862353e-03
## ASV3532     -2.282675e-03 -2.379870e-03 -2.480886e-03 -2.585859e-03
## ASV3600      2.855568e-03  2.975146e-03  3.099199e-03  3.227859e-03
## ASV4013      2.207261e-03  2.290801e-03  2.376799e-03  2.465282e-03
## ASV4136      2.066473e-03  2.140409e-03  2.216335e-03  2.294275e-03
## ASV4195      1.104321e-03  1.143847e-03  1.184348e-03  1.225822e-03
## ASV4407     -1.103522e-03 -1.142988e-03 -1.183427e-03 -1.224834e-03
## ASV4717     -2.221850e-05 -2.571958e-05 -2.942059e-05 -3.332070e-05
## ASV6794      1.033701e-03  1.068420e-03  1.104033e-03  1.140561e-03
## ASV8324     -1.103149e-03 -1.142586e-03 -1.182994e-03 -1.224369e-03
## ASV8981     -1.221542e-04 -1.176159e-04 -1.122047e-04 -1.058518e-04
## ASV9859      1.267180e-03  1.335074e-03  1.406688e-03  1.482221e-03
## ASV0936     -1.798193e-03 -1.866593e-03 -1.937069e-03 -2.009655e-03
## ASV12683    -2.509831e-04 -2.625091e-04 -2.744498e-04 -2.868081e-04
## ASV1293      2.534427e-03  2.625459e-03  2.718879e-03  2.814706e-03
## ASV13055    -2.034003e-04 -2.072471e-04 -2.108983e-04 -2.143280e-04
## ASV17063    -1.102563e-03 -1.142004e-03 -1.182421e-03 -1.223814e-03
## ASV2228      1.101765e-03  1.141147e-03  1.181502e-03  1.222829e-03
## ASV2769     -5.806863e-05 -5.367438e-05 -4.871735e-05 -4.316896e-05
## ASV2803      4.468939e-04  4.604629e-04  4.742753e-04  4.883322e-04
## ASV2896      1.620190e-03  1.692825e-03  1.768749e-03  1.848124e-03
## ASV3062      7.129571e-04  7.529901e-04  7.952278e-04  8.397746e-04
## ASV3107      1.903749e-03  1.984551e-03  2.068486e-03  2.155660e-03
## ASV3265      3.274414e-03  3.390720e-03  3.509943e-03  3.632092e-03
## ASV3666     -1.151413e-04 -1.214779e-04 -1.281855e-04 -1.352861e-04
## ASV4497      7.925000e-04  8.215876e-04  8.514829e-04  8.821943e-04
## ASV6914     -4.403111e-04 -4.584279e-04 -4.771728e-04 -4.965598e-04
## ASV0576     -3.609240e-03 -3.728279e-03 -3.849846e-03 -3.973935e-03
## ASV0673      1.302894e-03  1.361174e-03  1.421661e-03  1.484397e-03
## ASV0772      1.294373e-03  1.347050e-03  1.401639e-03  1.458199e-03
## ASV0862     -7.634367e-04 -7.823574e-04 -8.011368e-04 -8.197304e-04
## ASV0898      1.299342e-03  1.360396e-03  1.424067e-03  1.490437e-03
## ASV0910      2.684870e-03  2.808541e-03  2.937536e-03  3.072047e-03
## ASV0964     -1.332555e-03 -1.376586e-03 -1.421456e-03 -1.467145e-03
## ASV10059     1.313974e-03  1.377686e-03  1.444424e-03  1.514320e-03
## ASV10263    -1.107108e-03 -1.146954e-03 -1.187812e-03 -1.229684e-03
## ASV1088      1.485635e-03  1.558178e-03  1.634260e-03  1.714047e-03
## ASV1101      2.005771e-03  2.080323e-03  2.156785e-03  2.235139e-03
## ASV1183      1.367440e-03  1.423319e-03  1.481161e-03  1.541016e-03
## ASV11956     3.677725e-04  3.772695e-04  3.868336e-04  3.964618e-04
## ASV12774    -2.359352e-04 -2.474184e-04 -2.594157e-04 -2.719456e-04
## ASV1321      8.448781e-04  8.924422e-04  9.425869e-04  9.954288e-04
## ASV13793    -1.106149e-03 -1.145924e-03 -1.186707e-03 -1.228499e-03
## ASV14482    -1.649774e-04 -1.727921e-04 -1.808710e-04 -1.892126e-04
## ASV15483     9.176336e-04  9.576740e-04  9.993065e-04  1.042581e-03
## ASV2062      5.236304e-03  5.442816e-03  5.656091e-03  5.876263e-03
## ASV2132      2.619996e-03  2.734281e-03  2.853134e-03  2.976704e-03
## ASV2413      3.200884e-03  3.320348e-03  3.443349e-03  3.569946e-03
## ASV2490      1.959597e-03  2.025779e-03  2.093393e-03  2.162427e-03
## ASV2594      1.290060e-03  1.346428e-03  1.405260e-03  1.466669e-03
## ASV2822     -1.108146e-03 -1.148113e-03 -1.189106e-03 -1.231129e-03
## ASV2863      1.892823e-03  1.960638e-03  2.030268e-03  2.101733e-03
## ASV2910      2.444854e-03  2.531224e-03  2.619790e-03  2.710565e-03
## ASV2980      8.779092e-04  9.077601e-04  9.382275e-04  9.693003e-04
## ASV3307      1.106828e-03  1.146698e-03  1.187589e-03  1.229502e-03
## ASV3474      2.216373e-03  2.319384e-03  2.426857e-03  2.538948e-03
## ASV3502      3.935541e-03  4.094756e-03  4.259581e-03  4.430171e-03
## ASV4236      1.722425e-03  1.780283e-03  1.839358e-03  1.899638e-03
## ASV4842     -6.249594e-04 -6.477583e-04 -6.711140e-04 -6.950216e-04
## ASV4894     -1.108259e-03 -1.148265e-03 -1.189303e-03 -1.231378e-03
## ASV5290      1.477012e-03  1.535180e-03  1.595159e-03  1.656972e-03
## ASV5501      2.888576e-04  3.018537e-04  3.154673e-04  3.297316e-04
## ASV5795      1.116286e-03  1.166126e-03  1.218003e-03  1.271982e-03
## ASV5987     -1.108937e-03 -1.149013e-03 -1.190128e-03 -1.232286e-03
## ASV6267     -1.108127e-03 -1.148142e-03 -1.189193e-03 -1.231283e-03
## ASV6862      1.948286e-03  2.012467e-03  2.078036e-03  2.144994e-03
## ASV7145      3.424939e-04  3.542792e-04  3.664546e-04  3.790399e-04
## ASV7673     -1.107824e-03 -1.147816e-03 -1.188842e-03 -1.230907e-03
## ASV7789      7.181264e-04  7.600327e-04  8.043624e-04  8.512394e-04
## ASV7809      1.287024e-05  2.034705e-05  2.854563e-05  3.750654e-05
## ASV8002     -1.107840e-03 -1.147867e-03 -1.188933e-03 -1.231045e-03
## ASV8205      7.299416e-04  7.614479e-04  7.942527e-04  8.284057e-04
## ASV9155     -8.124501e-04 -8.407079e-04 -8.696138e-04 -8.991641e-04
## ASV9221      5.825026e-05  6.967040e-05  8.215990e-05  9.578855e-05
## ASV9311     -1.107172e-03 -1.147171e-03 -1.188213e-03 -1.230302e-03
## ASV9557     -1.106363e-03 -1.146303e-03 -1.187280e-03 -1.229299e-03
## ASV9936     -1.105556e-03 -1.145435e-03 -1.186348e-03 -1.228299e-03
## ASV1445      2.964573e-03  3.092245e-03  3.224952e-03  3.362861e-03
## ASV4232      2.731966e-03  2.861284e-03  2.996694e-03  3.138476e-03
## ASV6479      2.891595e-04  3.142528e-04  3.412055e-04  3.701291e-04
## ASV0142     -5.403103e-03 -5.591951e-03 -5.785420e-03 -5.983524e-03
## ASV0378     -1.601905e-03 -1.648200e-03 -1.694739e-03 -1.741440e-03
## ASV1122      3.910280e-03  4.077187e-03  4.250461e-03  4.430285e-03
## ASV0123     -5.272700e-03 -5.455985e-03 -5.643671e-03 -5.835764e-03
## ASV2064      4.377449e-04  4.482181e-04  4.586090e-04  4.688959e-04
## ASV4459     -5.852894e-04 -6.057341e-04 -6.267012e-04 -6.481991e-04
## ASV0448      1.469512e-03  1.546715e-03  1.627849e-03  1.713086e-03
## ASV0397      2.817682e-03  2.933639e-03  3.053735e-03  3.178074e-03
## ASV0485      3.783877e-03  3.934855e-03  4.091077e-03  4.252686e-03
## ASV1566      3.268520e-03  3.401204e-03  3.538463e-03  3.680403e-03
## ASV1365      2.148900e-03  2.237235e-03  2.328643e-03  2.423186e-03
## ASV1065      4.385477e-03  4.566733e-03  4.754578e-03  4.949196e-03
## ASV0722     -4.040112e-05 -4.082450e-05 -4.125708e-05 -4.170811e-05
## ASV12660    -1.750907e-03 -1.811232e-03 -1.872993e-03 -1.936195e-03
## ASV0223     -3.093450e-05 -2.915177e-05 -2.700478e-05 -2.445522e-05
## ASV0229      2.101440e-03  2.194899e-03  2.292264e-03  2.393680e-03
## ASV0877     -5.350939e-04 -5.492388e-04 -5.634703e-04 -5.777813e-04
## ASV0983      3.734986e-03  3.877065e-03  4.023483e-03  4.174313e-03
## ASV0626     -8.343955e-04 -8.501451e-04 -8.653795e-04 -8.800456e-04
## ASV4146     -1.824500e-04 -1.892211e-04 -1.963008e-04 -2.037186e-04
## ASV4175     -2.431234e-03 -2.529422e-03 -2.630966e-03 -2.735940e-03
## ASV2082     -4.270166e-04 -4.567645e-04 -4.885423e-04 -5.224715e-04
## ASV2272      1.904143e-03  1.988695e-03  2.076763e-03  2.168471e-03
## ASV2245     -2.176367e-03 -2.266962e-03 -2.360875e-03 -2.458199e-03
## ASV0590     -1.665777e-03 -1.749674e-03 -1.837634e-03 -1.929824e-03
## ASV0217     -1.025205e-03 -1.028270e-03 -1.028914e-03 -1.026944e-03
## ASV0416      1.509556e-03  1.551880e-03  1.594434e-03  1.637153e-03
## ASV1056      2.729376e-03  2.855166e-03  2.986245e-03  3.122777e-03
## ASV7777     -2.130147e-03 -2.218606e-03 -2.310382e-03 -2.405584e-03
## ASV0455      5.205227e-04  5.443642e-04  5.690912e-04  5.947123e-04
## ASV0604      7.710171e-04  8.146679e-04  8.606150e-04  9.089529e-04
## ASV6100     -1.996821e-03 -2.081237e-03 -2.168942e-03 -2.260055e-03
## ASV11359    -2.117640e-03 -2.200832e-03 -2.286689e-03 -2.375257e-03
## ASV6604      1.704886e-03  1.781776e-03  1.861938e-03  1.945492e-03
## ASV5004     -1.240374e-03 -1.289643e-03 -1.340609e-03 -1.393323e-03
## ASV1483     -1.171546e-03 -1.219073e-03 -1.268280e-03 -1.319213e-03
## ASV9773     -2.527425e-03 -2.632526e-03 -2.741552e-03 -2.854627e-03
## ASV4059      4.434899e-04  4.705468e-04  4.991842e-04  5.294780e-04
## ASV1193      4.041655e-03  4.205510e-03  4.375064e-03  4.550459e-03
## ASV4610     -2.248577e-05 -1.150905e-05  4.807382e-07  1.352419e-05
## ASV0742     -9.907739e-04 -1.010214e-03 -1.029051e-03 -1.047215e-03
## ASV1502     -1.913860e-04 -2.060258e-04 -2.216237e-04 -2.382263e-04
## ASV0195     -6.471036e-04 -6.809634e-04 -7.164684e-04 -7.536828e-04
## ASV1213      1.006916e-03  1.036081e-03  1.065452e-03  1.094984e-03
## ASV1648     -1.851560e-03 -1.928296e-03 -2.007941e-03 -2.090597e-03
## ASV6984     -1.434952e-03 -1.496772e-03 -1.561121e-03 -1.628101e-03
## ASV0396     -3.214274e-04 -3.058871e-04 -2.880185e-04 -2.676823e-04
## ASV4297      1.804410e-03  1.866922e-03  1.930945e-03  1.996486e-03
## ASV2622      4.291182e-03  4.448149e-03  4.609533e-03  4.775397e-03
## ASV3512      1.086023e-03  1.147357e-03  1.212209e-03  1.280769e-03
## ASV2411      1.864805e-03  1.950922e-03  2.040766e-03  2.134471e-03
## ASV2291     -6.335165e-04 -6.692430e-04 -7.069447e-04 -7.467159e-04
## ASV0807      2.413449e-03  2.531999e-03  2.655994e-03  2.785631e-03
## ASV1292      9.808877e-04  1.018097e-03  1.056522e-03  1.096201e-03
## ASV1035      3.801573e-04  3.921680e-04  4.044907e-04  4.171390e-04
## ASV0070     -6.388269e-04 -6.427758e-04 -6.452195e-04 -6.460102e-04
## ASV0255      4.275702e-04  4.418347e-04  4.561801e-04  4.705557e-04
## ASV0057     -4.027482e-03 -4.154336e-03 -4.283029e-03 -4.413445e-03
## ASV0077     -2.971304e-04 -2.913525e-04 -2.841581e-04 -2.754465e-04
## ASV0625      4.271198e-03  4.420043e-03  4.572416e-03  4.728304e-03
## ASV2464      1.974638e-03  2.040737e-03  2.108303e-03  2.177331e-03
## ASV1315      4.733930e-03  4.948270e-03  5.171664e-03  5.404430e-03
## ASV2673      3.569036e-03  3.737188e-03  3.913045e-03  4.096935e-03
## ASV2161      1.502187e-03  1.574240e-03  1.649674e-03  1.728637e-03
## ASV0337     -1.936274e-03 -2.010181e-03 -2.086291e-03 -2.164630e-03
## ASV7680     -2.459301e-03 -2.562577e-03 -2.669745e-03 -2.780923e-03
## ASV0611      5.665304e-03  5.918612e-03  6.182679e-03  6.457917e-03
## ASV3118     -1.879235e-03 -1.960437e-03 -2.044823e-03 -2.132496e-03
## ASV1284      1.981360e-03  2.067274e-03  2.156595e-03  2.249433e-03
## ASV0889      1.364189e-03  1.418431e-03  1.474597e-03  1.532749e-03
## ASV4649     -1.484775e-03 -1.545239e-03 -1.607846e-03 -1.672654e-03
## ASV1108     -2.231844e-03 -2.337836e-03 -2.448695e-03 -2.564619e-03
## ASV0738      4.637824e-04  5.152576e-04  5.708645e-04  6.308563e-04
## ASV0473      3.261381e-04  3.415277e-04  3.576488e-04  3.745342e-04
## ASV0598     -1.727297e-03 -1.780125e-03 -1.833660e-03 -1.887858e-03
## ASV0429      3.257349e-03  3.381231e-03  3.508798e-03  3.640098e-03
## ASV1549      4.017485e-03  4.207435e-03  4.406020e-03  4.613586e-03
## ASV1203      2.531752e-03  2.631508e-03  2.734497e-03  2.840776e-03
## ASV4532      4.355073e-05  4.402291e-05  4.457397e-05  4.522688e-05
## ASV0274     -2.137567e-03 -2.205651e-03 -2.274938e-03 -2.345401e-03
## ASV0163     -2.989845e-03 -3.081793e-03 -3.175077e-03 -3.269634e-03
## ASV1298      1.237245e-03  1.277894e-03  1.319501e-03  1.362089e-03
## ASV9424     -3.356588e-03 -3.502173e-03 -3.653616e-03 -3.811123e-03
## ASV0412      4.713197e-03  4.898282e-03  5.089428e-03  5.286762e-03
## ASV0284      1.843226e-03  1.904268e-03  1.966514e-03  2.029935e-03
## ASV0620     -1.915372e-03 -2.004776e-03 -2.098062e-03 -2.195367e-03
## ASV0153     -3.754700e-03 -3.922383e-03 -4.096919e-03 -4.278527e-03
## ASV0498      8.971573e-04  9.536645e-04  1.013289e-03  1.076144e-03
## ASV0097      2.799847e-03  2.931244e-03  3.068620e-03  3.212223e-03
## ASV0104     -1.107179e-02 -1.151438e-02 -1.197189e-02 -1.244466e-02
## ASV1282      2.041005e-03  2.126647e-03  2.215360e-03  2.307208e-03
## ASV3883     -1.292625e-03 -1.350908e-03 -1.411516e-03 -1.474509e-03
## ASV0801      1.400941e-03  1.469052e-03  1.540333e-03  1.614914e-03
## ASV1611     -4.573693e-03 -4.771092e-03 -4.976283e-03 -5.189520e-03
## ASV0227     -1.974987e-03 -2.072184e-03 -2.173946e-03 -2.280456e-03
## ASV0833      2.092154e-03  2.193213e-03  2.298818e-03  2.409130e-03
## ASV0718      4.105793e-03  4.276068e-03  4.452508e-03  4.635270e-03
## ASV1139      1.009497e-03  1.029609e-03  1.048896e-03  1.067239e-03
## ASV0766     -9.705084e-04 -1.004496e-03 -1.039326e-03 -1.075006e-03
## ASV2091      4.711440e-03  4.874561e-03  5.041543e-03  5.212384e-03
## ASV1238      4.373134e-05  6.172655e-05  8.143142e-05  1.029449e-04
## ASV9193     -8.071827e-04 -8.532025e-04 -9.016968e-04 -9.527710e-04
## ASV0290     -6.439396e-04 -6.760357e-04 -7.094214e-04 -7.441070e-04
## ASV0231      4.184510e-03  4.351163e-03  4.523409e-03  4.701369e-03
## ASV0185      1.968753e-03  2.103441e-03  2.246932e-03  2.399726e-03
## ASV2330      1.102187e-03  1.141757e-03  1.182402e-03  1.224137e-03
## ASV3119     -1.900477e-03 -1.999806e-03 -2.104219e-03 -2.213950e-03
## ASV2368     -2.234576e-03 -2.339767e-03 -2.449849e-03 -2.565042e-03
## ASV0122     -1.291249e-03 -1.334078e-03 -1.377813e-03 -1.422449e-03
## ASV1044      3.237372e-03  3.393823e-03  3.557546e-03  3.728836e-03
## ASV0160     -3.002704e-03 -3.092076e-03 -3.182438e-03 -3.273707e-03
## ASV0326      2.491996e-03  2.594115e-03  2.699773e-03  2.809043e-03
## ASV1388      4.256060e-03  4.427653e-03  4.605212e-03  4.788890e-03
## ASV0792      4.531468e-03  4.700102e-03  4.873460e-03  5.051576e-03
## ASV0036     -3.310981e-03 -3.454541e-03 -3.603602e-03 -3.758305e-03
## ASV2125      4.954455e-03  5.152250e-03  5.356642e-03  5.567762e-03
## ASV1075      1.121740e-03  1.174816e-03  1.230312e-03  1.288326e-03
## ASV0390      1.365722e-03  1.441738e-03  1.522071e-03  1.606953e-03
## ASV3790     -4.220567e-03 -4.400342e-03 -4.587019e-03 -4.780808e-03
## ASV1535     -5.061824e-04 -5.350133e-04 -5.654640e-04 -5.976123e-04
## ASV0263      8.558405e-04  8.916386e-04  9.287754e-04  9.672921e-04
## ASV0675      7.425731e-03  7.763418e-03  8.115562e-03  8.482694e-03
## ASV3348      8.408957e-04  8.846786e-04  9.307330e-04  9.791680e-04
## ASV0058     -6.113409e-03 -6.350544e-03 -6.595011e-03 -6.846913e-03
## ASV4142      1.483120e-03  1.538100e-03  1.594623e-03  1.652708e-03
## ASV0059     -5.210782e-03 -5.409801e-03 -5.614711e-03 -5.825571e-03
## ASV0013     -1.124216e-02 -1.169244e-02 -1.215804e-02 -1.263929e-02
## ASV0033     -3.648387e-03 -3.809012e-03 -3.976026e-03 -4.149619e-03
## ASV4354     -1.328247e-03 -1.378228e-03 -1.429811e-03 -1.483040e-03
## ASV0022     -3.808171e-03 -3.973684e-03 -4.145588e-03 -4.324055e-03
## ASV0134     -1.109610e-03 -1.164631e-03 -1.222300e-03 -1.282738e-03
## ASV0415     -3.160314e-04 -3.124906e-04 -3.078381e-04 -3.020021e-04
## ASV10103    -2.584873e-03 -2.694662e-03 -2.808609e-03 -2.926831e-03
## ASV1613      3.697183e-03  3.833207e-03  3.972877e-03  4.116204e-03
## ASV0135      3.947264e-04  4.386241e-04  4.861520e-04  5.375447e-04
## ASV0469     -4.595512e-03 -4.766787e-03 -4.943129e-03 -5.124624e-03
## ASV0471      3.234765e-03  3.369274e-03  3.508774e-03  3.653420e-03
## ASV0451     -1.143250e-03 -1.201731e-03 -1.263089e-03 -1.327442e-03
## ASV0747      1.534970e-03  1.609579e-03  1.687559e-03  1.769027e-03
## ASV1314     -2.333096e-03 -2.449931e-03 -2.572671e-03 -2.701606e-03
## ASV0425     -4.873120e-03 -5.037598e-03 -5.205572e-03 -5.377004e-03
## ASV0559     -2.830650e-03 -2.932933e-03 -3.038304e-03 -3.146857e-03
## ASV0148     -2.902479e-03 -2.993906e-03 -3.086588e-03 -3.180425e-03
## ASV0129     -1.082873e-03 -1.097574e-03 -1.110648e-03 -1.121914e-03
## ASV1072      1.347301e-03  1.386369e-03  1.425670e-03  1.465139e-03
## ASV2390      9.518398e-04  9.784150e-04  1.005000e-03  1.031533e-03
## ASV0548      3.800177e-03  3.961193e-03  4.128311e-03  4.301711e-03
## ASV0168     -5.174661e-03 -5.372224e-03 -5.575957e-03 -5.785983e-03
## ASV0066     -3.912928e-03 -4.063685e-03 -4.219023e-03 -4.378998e-03
## ASV0468     -1.523286e-03 -1.586661e-03 -1.652448e-03 -1.720732e-03
## ASV0172     -2.472249e-04 -2.308506e-04 -2.120475e-04 -1.906420e-04
## ASV0236     -1.284458e-03 -1.300854e-03 -1.315371e-03 -1.327819e-03
## ASV0250      1.082723e-03  1.170800e-03  1.265233e-03  1.366403e-03
## ASV0338      1.562868e-04  1.795667e-04  2.046039e-04  2.314742e-04
## ASV0450     -1.179253e-05 -1.237888e-05 -1.306302e-05 -1.386396e-05
## ASV0377      4.460629e-03  4.640689e-03  4.826895e-03  5.019376e-03
## ASV1022      1.310086e-03  1.367190e-03  1.426671e-03  1.488627e-03
## ASV6174     -2.801775e-04 -2.913467e-04 -3.029619e-04 -3.150424e-04
## ASV0786      3.712764e-04  3.813637e-04  3.915006e-04  4.016740e-04
## ASV0053     -5.434502e-03 -5.656893e-03 -5.887128e-03 -6.125398e-03
## ASV0697     -1.238605e-03 -1.275673e-03 -1.313163e-03 -1.351036e-03
## ASV0785      4.020107e-03  4.183919e-03  4.353525e-03  4.529081e-03
## ASV1967     -2.305287e-03 -2.386049e-03 -2.468869e-03 -2.553763e-03
## ASV0385     -9.418055e-04 -9.681335e-04 -9.946338e-04 -1.021276e-03
## ASV0295      5.406196e-04  5.871523e-04  6.371855e-04  6.909375e-04
## ASV0072     -3.722151e-03 -3.846748e-03 -3.973694e-03 -4.102909e-03
## ASV0157     -1.265764e-03 -1.291728e-03 -1.316518e-03 -1.339942e-03
## ASV0501      2.337440e-03  2.449019e-03  2.565661e-03  2.687559e-03
## ASV10729    -3.416584e-03 -3.560742e-03 -3.710271e-03 -3.865320e-03
## ASV1470      1.396347e-03  1.445464e-03  1.495716e-03  1.547089e-03
## ASV0050     -1.031590e-02 -1.071497e-02 -1.112650e-02 -1.155073e-02
## ASV0411     -3.661050e-05 -2.743276e-05 -1.719726e-05 -5.838414e-06
## ASV0549      2.389219e-03  2.502483e-03  2.620946e-03  2.744822e-03
## ASV0184      1.282099e-03  1.336904e-03  1.393953e-03  1.453337e-03
## ASV0705      1.641187e-03  1.711802e-03  1.785012e-03  1.860871e-03
## ASV1715      3.920302e-03  4.084534e-03  4.254906e-03  4.431596e-03
## ASV0603      5.644624e-04  5.938754e-04  6.249487e-04  6.577844e-04
## ASV0826      1.082997e-03  1.118625e-03  1.154928e-03  1.191889e-03
## ASV0034     -4.430418e-03 -4.589893e-03 -4.753353e-03 -4.920783e-03
## ASV0838      9.296405e-04  9.613512e-04  9.935582e-04  1.026213e-03
## ASV0614     -2.594184e-03 -2.691908e-03 -2.792453e-03 -2.895842e-03
## ASV0014     -1.006521e-02 -1.045817e-02 -1.086374e-02 -1.128217e-02
## ASV0585     -6.975744e-04 -7.270988e-04 -7.576615e-04 -7.892772e-04
## ASV0016     -1.031679e-02 -1.072083e-02 -1.113793e-02 -1.156833e-02
## ASV5394     -2.782172e-03 -2.897753e-03 -3.017458e-03 -3.141381e-03
## ASV0666      2.203095e-03  2.287979e-03  2.375462e-03  2.465582e-03
## ASV2085      3.598002e-04  3.524485e-04  3.434418e-04  3.326680e-04
## ASV0003     -9.324373e-03 -9.684682e-03 -1.005630e-02 -1.043942e-02
## ASV0346      3.766265e-04  4.147761e-04  4.557242e-04  4.996134e-04
## ASV0267     -1.156331e-03 -1.186212e-03 -1.215973e-03 -1.245554e-03
## ASV0353      2.686727e-03  2.822747e-03  2.965460e-03  3.115156e-03
## ASV2419      2.580189e-03  2.678266e-03  2.779360e-03  2.883525e-03
## ASV0447      1.922980e-03  2.026137e-03  2.134517e-03  2.248333e-03
## ASV0654      4.492239e-03  4.682178e-03  4.879034e-03  5.082967e-03
## ASV0151      1.124055e-03  1.191766e-03  1.263567e-03  1.339685e-03
## ASV0065     -3.803501e-03 -3.951048e-03 -4.103147e-03 -4.259859e-03
## ASV0527      2.791190e-03  2.901870e-03  3.016200e-03  3.134252e-03
## ASV4055     -1.289215e-03 -1.353095e-03 -1.420219e-03 -1.490756e-03
## ASV0166     -2.882661e-03 -2.983218e-03 -3.086183e-03 -3.191551e-03
## ASV0417     -2.604929e-03 -2.704464e-03 -2.807118e-03 -2.912956e-03
## ASV0078     -1.883450e-03 -1.943053e-03 -2.003331e-03 -2.064183e-03
## ASV0322     -2.313049e-03 -2.388852e-03 -2.465931e-03 -2.544223e-03
## ASV0156     -3.251601e-03 -3.373685e-03 -3.499439e-03 -3.628927e-03
## ASV0648     -3.398081e-03 -3.546092e-03 -3.699995e-03 -3.859982e-03
## ASV0407      4.217412e-04  4.469556e-04  4.736541e-04  5.019145e-04
## ASV2030     -5.143201e-04 -5.312227e-04 -5.486895e-04 -5.667593e-04
## ASV0300      2.323627e-03  2.437535e-03  2.556722e-03  2.681387e-03
## ASV1150     -5.407503e-05 -4.765205e-05 -4.035661e-05 -3.212410e-05
## ASV0958      2.479801e-03  2.606977e-03  2.740767e-03  2.881507e-03
## ASV0216     -2.921126e-03 -3.025122e-03 -3.132059e-03 -3.242006e-03
## ASV0446      5.288720e-03  5.529890e-03  5.781210e-03  6.043020e-03
## ASV0367     -1.548968e-03 -1.610456e-03 -1.674037e-03 -1.739762e-03
## ASV0200     -3.008191e-03 -3.133266e-03 -3.263006e-03 -3.397552e-03
## ASV0334     -8.473572e-04 -8.546468e-04 -8.605283e-04 -8.648930e-04
## ASV1311      1.955507e-03  2.028485e-03  2.103509e-03  2.180591e-03
## ASV0458      2.212178e-03  2.301156e-03  2.393262e-03  2.488580e-03
## ASV1371      9.626291e-05  1.012672e-04  1.065062e-04  1.119868e-04
## ASV0418      2.797940e-03  2.914475e-03  3.035407e-03  3.160876e-03
## ASV0004      3.235365e-03  3.364977e-03  3.498994e-03  3.637514e-03
## ASV1943      2.230511e-03  2.315750e-03  2.403689e-03  2.494383e-03
## ASV1495     -9.981196e-04 -1.057356e-03 -1.120082e-03 -1.186483e-03
## ASV0901     -4.118324e-03 -4.303974e-03 -4.497575e-03 -4.699434e-03
## ASV0628      1.934902e-03  2.001251e-03  2.068897e-03  2.137788e-03
## ASV0400      7.762863e-04  8.026125e-04  8.293885e-04  8.565815e-04
## ASV0116     -3.342580e-03 -3.499553e-03 -3.663604e-03 -3.835014e-03
## ASV0788      2.415385e-03  2.515348e-03  2.618912e-03  2.726170e-03
## ASV0117      1.896962e-03  1.991162e-03  2.089965e-03  2.193576e-03
## ASV3137      3.795690e-04  3.936023e-04  4.080608e-04  4.229564e-04
## ASV0001      3.401779e-03  3.517226e-03  3.635132e-03  3.755466e-03
## ASV1651      2.300982e-03  2.382499e-03  2.466217e-03  2.552174e-03
## ASV1692      3.227306e-03  3.377242e-03  3.533787e-03  3.697191e-03
## ASV0660      1.167874e-03  1.194076e-03  1.219483e-03  1.243944e-03
## ASV0508      7.230790e-05  7.119098e-05  6.984697e-05  6.826608e-05
## ASV1660     -1.394352e-03 -1.460267e-03 -1.529030e-03 -1.600734e-03
## ASV0233      8.272821e-04  8.702863e-04  9.155779e-04  9.632761e-04
## ASV1343     -2.973171e-03 -3.101400e-03 -3.234723e-03 -3.373315e-03
## ASV0209      2.209924e-03  2.283826e-03  2.359322e-03  2.436405e-03
## ASV0193     -3.068711e-03 -3.180366e-03 -3.295117e-03 -3.413004e-03
## ASV0357      2.145683e-04  2.433013e-04  2.746601e-04  3.088349e-04
## ASV0198      7.878167e-04  8.233296e-04  8.604370e-04  8.992146e-04
## ASV0007      3.225211e-03  3.334724e-03  3.446578e-03  3.560742e-03
## ASV1772     -3.165152e-04 -3.248069e-04 -3.328711e-04 -3.406427e-04
## ASV0009      3.010834e-03  3.111589e-03  3.214384e-03  3.319180e-03
## ASV0006      8.783600e-04  8.914327e-04  9.034329e-04  9.142494e-04
## ASV0011     -4.237259e-03 -4.422758e-03 -4.615741e-03 -4.816461e-03
## ASV0015      2.727658e-03  2.836640e-03  2.949245e-03  3.065541e-03
## ASV0017      2.868554e-03  2.982762e-03  3.100777e-03  3.222677e-03
## ASV0235     -2.433228e-03 -2.537083e-03 -2.644881e-03 -2.756737e-03
## ASV0382      8.877148e-04  9.409500e-04  9.969137e-04  1.055683e-03
## ASV2357      3.653235e-03  3.809778e-03  3.972522e-03  4.141684e-03
## ASV0567     -2.427272e-03 -2.523903e-03 -2.624047e-03 -2.727832e-03
## ASV0165      2.774334e-03  2.886859e-03  3.003310e-03  3.123783e-03
## ASV0005      5.232453e-03  5.427430e-03  5.627824e-03  5.833665e-03
## ASV0384      1.058423e-04  1.285533e-04  1.536059e-04  1.811861e-04
## ASV0002      1.480417e-03  1.553817e-03  1.630819e-03  1.711584e-03
## ASV3017      2.950494e-03  3.057420e-03  3.167253e-03  3.280026e-03
## ASV0091      1.401638e-03  1.464567e-03  1.530077e-03  1.598249e-03
## ASV0186     -3.488470e-03 -3.633797e-03 -3.784295e-03 -3.940073e-03
## ASV0370      4.369138e-04  4.594760e-04  4.832708e-04  5.083713e-04
## ASV0018      5.520184e-03  5.729447e-03  5.944834e-03  6.166407e-03
## ASV1377      4.789185e-03  4.971300e-03  5.158962e-03  5.352264e-03
## ASV0019      5.536022e-03  5.746376e-03  5.962935e-03  6.185765e-03
## ASV0023     -1.189285e-04 -1.454887e-04 -1.744163e-04 -2.058449e-04
## ASV2194      2.137032e-03  2.235119e-03  2.337539e-03  2.444463e-03
## ASV1155      5.815206e-05  7.260398e-05  8.838384e-05  1.055672e-04
## ASV0510     -1.541706e-03 -1.580226e-03 -1.618606e-03 -1.656776e-03
## ASV2371     -1.747276e-03 -1.804997e-03 -1.863923e-03 -1.924042e-03
## ASV0024     -4.032620e-04 -4.415530e-04 -4.826362e-04 -5.266572e-04
## ASV2452      2.330537e-03  2.406487e-03  2.483739e-03  2.562245e-03
## ASV2332      5.962133e-04  6.375897e-04  6.814672e-04  7.279603e-04
## ASV2591      5.688964e-04  6.077617e-04  6.488747e-04  6.923262e-04
## ASV0521      4.207638e-03  4.399397e-03  4.599429e-03  4.808048e-03
## ASV5542      1.376268e-03  1.439738e-03  1.505867e-03  1.574745e-03
## ASV0336     -1.718898e-03 -1.787482e-03 -1.858435e-03 -1.931823e-03
## ASV10102     2.773217e-03  2.892095e-03  3.015461e-03  3.143434e-03
## ASV16823    -1.643092e-03 -1.695900e-03 -1.749772e-03 -1.804703e-03
## ASV3104      1.642139e-03  1.694888e-03  1.748700e-03  1.803567e-03
## ASV0781      9.109772e-04  9.447024e-04  9.794095e-04  1.015119e-03
## ASV10899     1.415137e-03  1.491639e-03  1.572128e-03  1.656783e-03
## ASV11222    -1.641925e-03 -1.694683e-03 -1.748506e-03 -1.803388e-03
## ASV11327    -1.640973e-03 -1.693673e-03 -1.747435e-03 -1.802253e-03
## ASV12458    -1.640022e-03 -1.692664e-03 -1.746365e-03 -1.801119e-03
## ASV1636     -1.297944e-03 -1.337262e-03 -1.377206e-03 -1.417764e-03
## ASV1890     -1.744712e-03 -1.807051e-03 -1.871249e-03 -1.937358e-03
## ASV2898      4.085831e-03  4.238507e-03  4.395624e-03  4.557243e-03
## ASV8328      2.036323e-04  2.335063e-04  2.658730e-04  3.008813e-04
## ASV0709     -3.380851e-03 -3.508127e-03 -3.639114e-03 -3.773860e-03
## ASV0856      7.742735e-04  8.137809e-04  8.552123e-04  8.986467e-04
## ASV0909     -8.399598e-04 -8.466823e-04 -8.518618e-04 -8.553668e-04
## ASV0937     -2.973463e-03 -3.104569e-03 -3.241258e-03 -3.383759e-03
## ASV11390    -1.638205e-03 -1.690740e-03 -1.744331e-03 -1.798971e-03
## ASV11966     1.352837e-03  1.419571e-03  1.489381e-03  1.562380e-03
## ASV12990     5.751367e-04  5.981903e-04  6.219894e-04  6.465497e-04
## ASV14797     1.836108e-03  1.899412e-03  1.964229e-03  2.030570e-03
## ASV14904    -1.638345e-03 -1.690907e-03 -1.744528e-03 -1.799200e-03
## ASV15304     9.084426e-04  9.585927e-04  1.011309e-03  1.066696e-03
## ASV16696    -1.637906e-03 -1.690458e-03 -1.744069e-03 -1.798734e-03
## ASV1690      1.440990e-03  1.512272e-03  1.586685e-03  1.664319e-03
## ASV2029      5.434882e-03  5.647395e-03  5.866846e-03  6.093386e-03
## ASV2834      3.113788e-03  3.244729e-03  3.380604e-03  3.521559e-03
## ASV4003      1.416982e-03  1.497522e-03  1.582554e-03  1.672307e-03
## ASV4064      2.298132e-03  2.397666e-03  2.501019e-03  2.608299e-03
## ASV4294      1.150355e-03  1.214591e-03  1.282335e-03  1.353759e-03
## ASV4609      2.662297e-05  3.164491e-05  3.710262e-05  4.302472e-05
## ASV6283     -1.639350e-03 -1.692070e-03 -1.745865e-03 -1.800733e-03
## ASV6491     -1.638399e-03 -1.691060e-03 -1.744795e-03 -1.799598e-03
## ASV7453      1.228136e-03  1.294218e-03  1.363647e-03  1.436560e-03
## ASV7959      5.644801e-04  6.027347e-04  6.433110e-04  6.863225e-04
## ASV8219      1.638491e-03  1.691196e-03  1.744980e-03  1.799840e-03
## ASV8547     -1.637541e-03 -1.690187e-03 -1.743910e-03 -1.798705e-03
## ASV9319      1.565579e-03  1.636924e-03  1.711371e-03  1.789048e-03
## ASV9382     -1.637276e-03 -1.689922e-03 -1.743647e-03 -1.798446e-03
## ASV11516    -1.636327e-03 -1.688914e-03 -1.742578e-03 -1.797313e-03
## ASV14377    -1.635378e-03 -1.687907e-03 -1.741510e-03 -1.796181e-03
## ASV1867      3.205064e-03  3.343555e-03  3.487443e-03  3.636894e-03
## ASV1895     -5.335425e-04 -5.506328e-04 -5.681858e-04 -5.862233e-04
## ASV3168      1.094721e-03  1.129746e-03  1.165250e-03  1.201196e-03
## ASV4449      2.234734e-03  2.316097e-03  2.399898e-03  2.486192e-03
## ASV6596      1.951339e-03  2.051858e-03  2.157471e-03  2.268415e-03
## ASV7492     -2.722983e-04 -2.653883e-04 -2.571399e-04 -2.474649e-04
## ASV9854     -7.785829e-04 -8.014426e-04 -8.246464e-04 -8.481852e-04
## ASV6296      1.634078e-03  1.686557e-03  1.740110e-03  1.794734e-03
## ASV4201      1.290192e-03  1.367510e-03  1.449249e-03  1.535627e-03
## ASV0552      5.425712e-03  5.662658e-03  5.908922e-03  6.164778e-03
## ASV3671     -9.009859e-05 -8.331371e-05 -7.580942e-05 -6.756194e-05
## ASV3529     -8.427890e-07  1.407981e-05  3.029709e-05  4.786329e-05
## ASV1060      1.441261e-03  1.509605e-03  1.581250e-03  1.656360e-03
## ASV0239     -2.285496e-03 -2.355534e-03 -2.426524e-03 -2.498409e-03
## ASV5711     -2.282867e-03 -2.364475e-03 -2.448363e-03 -2.534566e-03
## ASV4152     -3.279543e-03 -3.406803e-03 -3.538193e-03 -3.673799e-03
## ASV1461      2.554997e-03  2.637186e-03  2.720871e-03  2.806024e-03
## ASV2877      2.354427e-03  2.441865e-03  2.531704e-03  2.623956e-03
## ASV0012      2.232830e-03  2.338601e-03  2.449184e-03  2.564770e-03
## ASV9823      4.726107e-04  4.824676e-04  4.920032e-04  5.011707e-04
## ASV0008      2.370714e-03  2.480881e-03  2.595960e-03  2.716144e-03
## ASV7832     -1.958954e-03 -2.033755e-03 -2.110991e-03 -2.190722e-03
## ASV1915      3.444007e-04  3.631994e-04  3.827860e-04  4.031668e-04
## ASV0055      1.426121e-03  1.481402e-03  1.538341e-03  1.596946e-03
## ASV0032      3.201093e-03  3.317289e-03  3.436682e-03  3.559314e-03
## ASV2977     -2.749077e-03 -2.854949e-03 -2.964175e-03 -3.076816e-03
## ASV0466      2.533375e-03  2.619404e-03  2.707315e-03  2.797085e-03
## ASV3866      3.308545e-03  3.451998e-03  3.601245e-03  3.756500e-03
## ASV0040      4.578256e-03  4.783249e-03  4.996794e-03  5.219192e-03
## ASV0496     -6.783580e-04 -7.249130e-04 -7.744039e-04 -8.269811e-04
## ASV0052      4.807228e-03  4.991401e-03  5.181151e-03  5.376553e-03
## ASV3828     -2.921716e-03 -3.036515e-03 -3.155350e-03 -3.278349e-03
## ASV1930      1.915601e-03  1.990136e-03  2.066887e-03  2.145872e-03
## ASV2126      3.057702e-03  3.177436e-03  3.301025e-03  3.428542e-03
## ASV0793      2.384177e-03  2.500942e-03  2.623115e-03  2.750906e-03
## ASV0299     -9.021879e-04 -9.248352e-04 -9.476398e-04 -9.706073e-04
## ASV0208      3.393081e-03  3.551969e-03  3.718079e-03  3.891716e-03
## ASV0511     -9.977691e-04 -1.014013e-03 -1.029300e-03 -1.043540e-03
## ASV1123     -1.656692e-03 -1.706565e-03 -1.757107e-03 -1.808280e-03
## ASV0099     -9.681785e-04 -9.957855e-04 -1.023202e-03 -1.050313e-03
## ASV0752     -4.283242e-04 -4.520651e-04 -4.769765e-04 -5.031006e-04
## ASV0883      1.556769e-04  1.665053e-04  1.779752e-04  1.901141e-04
## ASV0683      2.970189e-03  3.105415e-03  3.246410e-03  3.393383e-03
## ASV4117     -2.960444e-03 -3.076918e-03 -3.197421e-03 -3.322068e-03
## ASV2172      1.197583e-03  1.247596e-03  1.299494e-03  1.353338e-03
## ASV0330     -2.187909e-03 -2.279132e-03 -2.373687e-03 -2.471667e-03
## ASV0728      2.287238e-03  2.390017e-03  2.496987e-03  2.608285e-03
## ASV0499      4.530714e-03  4.741136e-03  4.960971e-03  5.190600e-03
## ASV0120     -4.331967e-03 -4.502772e-03 -4.679007e-03 -4.860755e-03
## ASV1446      1.742459e-05  3.369253e-06 -1.228107e-05 -2.964855e-05
## ASV17171    -2.865302e-03 -2.980605e-03 -3.100108e-03 -3.223947e-03
## ASV0533      1.026336e-03  1.076552e-03  1.129183e-03  1.184337e-03
## ASV2495     -1.393483e-03 -1.460906e-03 -1.531623e-03 -1.605786e-03
## ASV5582      7.441693e-04  7.622068e-04  7.801055e-04  7.978240e-04
## ASV1488      1.101473e-03  1.151532e-03  1.203630e-03  1.257825e-03
## ASV0682      3.134153e-03  3.278225e-03  3.428575e-03  3.585440e-03
## ASV0068     -4.986184e-04 -5.313815e-04 -5.659954e-04 -6.025259e-04
## ASV1987     -1.937543e-03 -2.034949e-03 -2.137116e-03 -2.244255e-03
## ASV0035     -1.380264e-04 -1.756372e-04 -2.171930e-04 -2.629995e-04
## ASV7192     -1.667004e-03 -1.721609e-03 -1.777238e-03 -1.833861e-03
## ASV0873      3.149368e-05  2.409216e-05  1.600678e-05  7.211781e-06
## ASV4749     -4.050714e-04 -4.463793e-04 -4.909103e-04 -5.388570e-04
## ASV2174      1.506872e-03  1.553964e-03  1.601975e-03  1.650917e-03
## ASV1476     -1.748480e-03 -1.826081e-03 -1.907013e-03 -1.991407e-03
## ASV0740     -4.493025e-03 -4.696581e-03 -4.908803e-03 -5.130011e-03
## ASV0170      8.750993e-04  9.122256e-04  9.508134e-04  9.909136e-04
## ASV2466     -3.674473e-03 -3.828411e-03 -3.988341e-03 -4.154477e-03
## ASV1709      2.704652e-03  2.810304e-03  2.919412e-03  3.032049e-03
## ASV6170     -2.758011e-03 -2.876690e-03 -2.999991e-03 -3.128059e-03
## ASV3673      3.175880e-03  3.313366e-03  3.456267e-03  3.604755e-03
## ASV1745      2.474183e-04  2.578031e-04  2.685334e-04  2.796113e-04
##                                                                    
## (Intercept) -1.333640e-03 -1.466114e-03 -1.609724e-03 -1.741446e-03
## ASV1236      2.173605e-03  2.247488e-03  2.323107e-03  2.371124e-03
## ASV0421     -3.961283e-03 -4.098668e-03 -4.239391e-03 -4.339618e-03
## ASV0691     -3.049249e-03 -3.141573e-03 -3.235484e-03 -3.288439e-03
## ASV0899      1.793237e-04  1.915313e-04  2.041620e-04  2.157685e-04
## ASV1004      4.498861e-03  4.653522e-03  4.811726e-03  4.920917e-03
## ASV1041     -3.024522e-03 -3.125829e-03 -3.229128e-03 -3.295498e-03
## ASV1058      4.233185e-03  4.383027e-03  4.536795e-03  4.655907e-03
## ASV12542     1.100729e-03  1.132649e-03  1.165044e-03  1.182230e-03
## ASV1294      5.124728e-03  5.313637e-03  5.507917e-03  5.660954e-03
## ASV13113     2.351102e-03  2.462097e-03  2.578190e-03  2.701766e-03
## ASV1318      4.285202e-03  4.435314e-03  4.589140e-03  4.698783e-03
## ASV2269     -1.272157e-03 -1.315746e-03 -1.360290e-03 -1.389698e-03
## ASV2542      3.414966e-03  3.565289e-03  3.721725e-03  3.876026e-03
## ASV2660     -2.320792e-03 -2.396103e-03 -2.472902e-03 -2.523630e-03
## ASV2737     -2.528468e-04 -2.653285e-04 -2.782439e-04 -2.938656e-04
## ASV2840      2.980862e-03  3.071868e-03  3.164165e-03  3.219203e-03
## ASV3053      1.407178e-04  1.452945e-04  1.500631e-04  1.557236e-04
## ASV3077      9.891042e-04  1.023520e-03  1.058876e-03  1.089137e-03
## ASV3134      4.619951e-03  4.833845e-03  5.057315e-03  5.289865e-03
## ASV3140      1.860368e-03  1.937711e-03  2.017784e-03  2.090383e-03
## ASV3579      1.120350e-03  1.182753e-03  1.248495e-03  1.324941e-03
## ASV6119     -1.270708e-03 -1.314241e-03 -1.358731e-03 -1.390335e-03
## ASV7557     -1.269647e-03 -1.313105e-03 -1.357515e-03 -1.390430e-03
## ASV8422      6.249874e-04  6.449426e-04  6.653767e-04  6.757400e-04
## ASV1086     -3.129546e-04 -3.232991e-04 -3.339568e-04 -3.450135e-04
## ASV1310      2.532261e-03  2.623726e-03  2.717483e-03  2.787733e-03
## ASV15750    -5.372079e-04 -5.523385e-04 -5.675287e-04 -5.762998e-04
## ASV16905    -1.269308e-03 -1.312751e-03 -1.357149e-03 -1.390858e-03
## ASV2033      3.047368e-03  3.182404e-03  3.322822e-03  3.457063e-03
## ASV2089      8.817719e-04  9.121230e-04  9.431243e-04  9.648186e-04
## ASV2127      3.563255e-03  3.691626e-03  3.823457e-03  3.926605e-03
## ASV2725      3.688174e-03  3.806839e-03  3.927751e-03  4.002963e-03
## ASV2804     -1.269537e-03 -1.313024e-03 -1.357471e-03 -1.391095e-03
## ASV3075      2.766249e-03  2.878866e-03  2.995785e-03  3.103639e-03
## ASV3327      2.911145e-03  3.038987e-03  3.171965e-03  3.299265e-03
## ASV3342      2.981409e-03  3.104824e-03  3.232719e-03  3.349875e-03
## ASV3532     -2.694929e-03 -2.808241e-03 -2.925949e-03 -3.040608e-03
## ASV3600      3.361258e-03  3.499533e-03  3.642817e-03  3.771943e-03
## ASV4013      2.556274e-03  2.649795e-03  2.745866e-03  2.821087e-03
## ASV4136      2.374253e-03  2.456294e-03  2.540423e-03  2.604572e-03
## ASV4195      1.268264e-03  1.311670e-03  1.356032e-03  1.391375e-03
## ASV4407     -1.267206e-03 -1.310537e-03 -1.354819e-03 -1.391439e-03
## ASV4717     -3.741779e-05 -4.170832e-05 -4.618724e-05 -5.768058e-05
## ASV6794      1.178028e-03  1.216461e-03  1.255885e-03  1.280137e-03
## ASV8324     -1.266708e-03 -1.310003e-03 -1.354249e-03 -1.391726e-03
## ASV8981     -9.848555e-05 -9.003147e-05 -8.041230e-05 -6.548933e-05
## ASV9859      1.561881e-03  1.645883e-03  1.734456e-03  1.833658e-03
## ASV0936     -2.084383e-03 -2.161287e-03 -2.240399e-03 -2.303223e-03
## ASV12683    -2.995860e-04 -3.127839e-04 -3.264014e-04 -3.415859e-04
## ASV1293      2.912953e-03  3.013634e-03  3.116763e-03  3.194319e-03
## ASV13055    -2.175089e-04 -2.204124e-04 -2.230090e-04 -2.255522e-04
## ASV17063    -1.266179e-03 -1.309512e-03 -1.353806e-03 -1.391967e-03
## ASV2228      1.265123e-03  1.308381e-03  1.352596e-03  1.392012e-03
## ASV2769     -3.700125e-05 -3.018716e-05 -2.270069e-05 -1.537945e-05
## ASV2803      5.026356e-04  5.171881e-04  5.319934e-04  5.363118e-04
## ASV2896      1.931116e-03  2.017904e-03  2.108674e-03  2.199787e-03
## ASV3062      8.867378e-04  9.362275e-04  9.883559e-04  1.044689e-03
## ASV3107      2.246176e-03  2.340143e-03  2.437671e-03  2.529199e-03
## ASV3265      3.757169e-03  3.885174e-03  4.016104e-03  4.116268e-03
## ASV3666     -1.428026e-04 -1.507591e-04 -1.591806e-04 -1.735410e-04
## ASV4497      9.137297e-04  9.460967e-04  9.793027e-04  1.003456e-03
## ASV6914     -5.166024e-04 -5.373145e-04 -5.587094e-04 -5.806744e-04
## ASV0576     -4.100541e-03 -4.229659e-03 -4.361282e-03 -4.448792e-03
## ASV0673      1.549424e-03  1.616781e-03  1.686502e-03  1.753413e-03
## ASV0772      1.516789e-03  1.577471e-03  1.640307e-03  1.698048e-03
## ASV0862     -8.380926e-04 -8.561772e-04 -8.739375e-04 -8.822338e-04
## ASV0898      1.559590e-03  1.631606e-03  1.706567e-03  1.777578e-03
## ASV0910      3.212266e-03  3.358391e-03  3.510620e-03  3.666148e-03
## ASV0964     -1.513632e-03 -1.560894e-03 -1.608907e-03 -1.645339e-03
## ASV10059     1.587510e-03  1.664135e-03  1.744338e-03  1.829118e-03
## ASV10263    -1.272570e-03 -1.316469e-03 -1.361380e-03 -1.392598e-03
## ASV1088      1.797709e-03  1.885422e-03  1.977369e-03  2.075906e-03
## ASV1101      2.315359e-03  2.397415e-03  2.481270e-03  2.546712e-03
## ASV1183      1.602935e-03  1.666969e-03  1.733167e-03  1.791155e-03
## ASV11956     4.061523e-04  4.159039e-04  4.257169e-04  4.282967e-04
## ASV12774    -2.850265e-04 -2.986772e-04 -3.129167e-04 -3.277900e-04
## ASV1321      1.051087e-03  1.109684e-03  1.171342e-03  1.242603e-03
## ASV13793    -1.271300e-03 -1.315109e-03 -1.359924e-03 -1.392656e-03
## ASV14482    -1.978141e-04 -2.066721e-04 -2.157817e-04 -2.223523e-04
## ASV15483     1.087547e-03  1.134257e-03  1.182760e-03  1.227958e-03
## ASV2062      6.103469e-03  6.337841e-03  6.579509e-03  6.795278e-03
## ASV2132      3.105140e-03  3.238597e-03  3.377228e-03  3.506636e-03
## ASV2413      3.700198e-03  3.834162e-03  3.971899e-03  4.092868e-03
## ASV2490      2.232869e-03  2.304702e-03  2.377911e-03  2.431317e-03
## ASV2594      1.530775e-03  1.597704e-03  1.667587e-03  1.744441e-03
## ASV2822     -1.274183e-03 -1.318269e-03 -1.363387e-03 -1.392788e-03
## ASV2863      2.175055e-03  2.250254e-03  2.327350e-03  2.388090e-03
## ASV2910      2.803563e-03  2.898797e-03  2.996278e-03  3.067266e-03
## ASV2980      1.000966e-03  1.033212e-03  1.066023e-03  1.084744e-03
## ASV3307      1.272440e-03  1.316403e-03  1.361390e-03  1.392856e-03
## ASV3474      2.655811e-03  2.777603e-03  2.904481e-03  3.034908e-03
## ASV3502      4.606683e-03  4.789278e-03  4.978120e-03  5.149177e-03
## ASV4236      1.961110e-03  2.023759e-03  2.087570e-03  2.147557e-03
## ASV4842     -7.194747e-04 -7.444660e-04 -7.699870e-04 -7.808084e-04
## ASV4894     -1.274492e-03 -1.318647e-03 -1.363843e-03 -1.392941e-03
## ASV5290      1.720635e-03  1.786165e-03  1.853573e-03  1.907237e-03
## ASV5501      3.446814e-04  3.603538e-04  3.767876e-04  4.035809e-04
## ASV5795      1.328125e-03  1.386500e-03  1.447170e-03  1.511334e-03
## ASV5987     -1.275492e-03 -1.319748e-03 -1.365055e-03 -1.393036e-03
## ASV6267     -1.274415e-03 -1.318593e-03 -1.363817e-03 -1.393073e-03
## ASV6862      2.213345e-03  2.283090e-03  2.354234e-03  2.407025e-03
## ASV7145      3.920563e-04  4.055264e-04  4.194745e-04  4.404384e-04
## ASV7673     -1.274013e-03 -1.318162e-03 -1.363357e-03 -1.393201e-03
## ASV7789      9.007921e-04  9.531529e-04  1.008458e-03  1.079030e-03
## ASV7809      4.727087e-05  5.788001e-05  6.937550e-05  9.078029e-05
## ASV8002     -1.274206e-03 -1.318420e-03 -1.363689e-03 -1.393353e-03
## ASV8205      8.639582e-04  9.009625e-04  9.394728e-04  9.780972e-04
## ASV9155     -9.293545e-04 -9.601800e-04 -9.916348e-04 -1.009930e-03
## ASV9221      1.106288e-04  1.267557e-04  1.442468e-04  1.734753e-04
## ASV9311     -1.273441e-03 -1.317636e-03 -1.362889e-03 -1.393651e-03
## ASV9557     -1.272366e-03 -1.316483e-03 -1.361653e-03 -1.393734e-03
## ASV9936     -1.271292e-03 -1.315331e-03 -1.360419e-03 -1.393823e-03
## ASV1445      3.506143e-03  3.654972e-03  3.809526e-03  3.959898e-03
## ASV4232      3.286924e-03  3.442341e-03  3.605043e-03  3.779057e-03
## ASV6479      4.011393e-04  4.343565e-04  4.699050e-04  5.219623e-04
## ASV0142     -6.186269e-03 -6.393663e-03 -6.605707e-03 -6.771620e-03
## ASV0378     -1.788218e-03 -1.834983e-03 -1.881639e-03 -1.910699e-03
## ASV1122      4.616846e-03  4.810331e-03  5.010927e-03  5.205523e-03
## ASV0123     -6.032263e-03 -6.233165e-03 -6.438464e-03 -6.603837e-03
## ASV2064      4.790568e-04  4.890698e-04  4.989130e-04  5.171539e-04
## ASV4459     -6.702369e-04 -6.928248e-04 -7.159739e-04 -7.228895e-04
## ASV0448      1.802604e-03  1.896586e-03  1.995218e-03  2.088498e-03
## ASV0397      3.306764e-03  3.439909e-03  3.577614e-03  3.688848e-03
## ASV0485      4.419832e-03  4.592665e-03  4.771339e-03  4.925246e-03
## ASV1566      3.827125e-03  3.978734e-03  4.135331e-03  4.280711e-03
## ASV1365      2.520923e-03  2.621912e-03  2.726206e-03  2.824310e-03
## ASV1065      5.150771e-03  5.359490e-03  5.575540e-03  5.772475e-03
## ASV0722     -4.218850e-05 -4.271097e-05 -4.329021e-05 -4.788240e-05
## ASV12660    -2.000838e-03 -2.066924e-03 -2.134451e-03 -2.179364e-03
## ASV0223     -2.146178e-05 -1.798002e-05 -1.396223e-05 -1.190958e-05
## ASV0229      2.499295e-03  2.609260e-03  2.723732e-03  2.830024e-03
## ASV0877     -5.921659e-04 -6.066197e-04 -6.211398e-04 -6.336727e-04
## ASV0983      4.329630e-03  4.489505e-03  4.654009e-03  4.792202e-03
## ASV0626     -8.940904e-04 -9.074621e-04 -9.201097e-04 -9.262637e-04
## ASV4146     -2.115077e-04 -2.197053e-04 -2.283532e-04 -2.418283e-04
## ASV4175     -2.844417e-03 -2.956470e-03 -3.072170e-03 -3.177807e-03
## ASV2082     -5.586786e-04 -5.972952e-04 -6.384578e-04 -6.841219e-04
## ASV2272      2.263948e-03  2.363321e-03  2.466721e-03  2.570188e-03
## ASV2245     -2.559029e-03 -2.663460e-03 -2.771589e-03 -2.875730e-03
## ASV0590     -2.026417e-03 -2.127587e-03 -2.233512e-03 -2.344109e-03
## ASV0217     -1.022162e-03 -1.014362e-03 -1.003338e-03 -9.662162e-04
## ASV0416      1.679970e-03  1.722813e-03  1.765607e-03  1.786313e-03
## ASV1056      3.264929e-03  3.412862e-03  3.566742e-03  3.714407e-03
## ASV7777     -2.504326e-03 -2.606724e-03 -2.712900e-03 -2.816926e-03
## ASV0455      6.212336e-04  6.486583e-04  6.769864e-04  7.084769e-04
## ASV0604      9.597774e-04  1.013186e-03  1.069277e-03  1.124315e-03
## ASV6100     -2.354696e-03 -2.452993e-03 -2.555077e-03 -2.658614e-03
## ASV11359    -2.466580e-03 -2.560701e-03 -2.657660e-03 -2.748916e-03
## ASV6604      2.032564e-03  2.123280e-03  2.217772e-03  2.306846e-03
## ASV5004     -1.447834e-03 -1.504196e-03 -1.562464e-03 -1.623758e-03
## ASV1483     -1.371920e-03 -1.426446e-03 -1.482841e-03 -1.541068e-03
## ASV9773     -2.971880e-03 -3.093440e-03 -3.219444e-03 -3.349370e-03
## ASV4059      5.615061e-04  5.953477e-04  6.310835e-04  6.703488e-04
## ASV1193      4.731831e-03  4.919321e-03  5.113068e-03  5.283316e-03
## ASV4610      2.766020e-05  4.292559e-05  5.935467e-05  7.930444e-05
## ASV0742     -1.064634e-03 -1.081239e-03 -1.096957e-03 -1.104843e-03
## ASV1502     -2.558810e-04 -2.746359e-04 -2.945398e-04 -3.239441e-04
## ASV0195     -7.926724e-04 -8.335044e-04 -8.762473e-04 -9.233486e-04
## ASV1213      1.124630e-03  1.154339e-03  1.184060e-03  1.214234e-03
## ASV1648     -2.176372e-03 -2.265376e-03 -2.357727e-03 -2.453570e-03
## ASV6984     -1.697819e-03 -1.770386e-03 -1.845918e-03 -1.932527e-03
## ASV0396     -2.447376e-04 -2.190428e-04 -1.904561e-04 -1.337468e-04
## ASV4297      2.063548e-03  2.132134e-03  2.202248e-03  2.250070e-03
## ASV2622      4.945802e-03  5.120808e-03  5.300476e-03  5.449099e-03
## ASV3512      1.353238e-03  1.429824e-03  1.510744e-03  1.598019e-03
## ASV2411      2.232170e-03  2.333998e-03  2.440091e-03  2.552245e-03
## ASV2291     -7.886536e-04 -8.328569e-04 -8.794277e-04 -9.200621e-04
## ASV0807      2.921110e-03  3.062632e-03  3.210399e-03  3.362784e-03
## ASV1292      1.137173e-03  1.179479e-03  1.223162e-03  1.271631e-03
## ASV1035      4.301284e-04  4.434759e-04  4.572004e-04  4.722176e-04
## ASV0070     -6.449926e-04 -6.420040e-04 -6.368743e-04 -6.114352e-04
## ASV0255      4.849038e-04  4.991596e-04  5.132506e-04  5.245047e-04
## ASV0057     -4.545456e-03 -4.678924e-03 -4.813701e-03 -4.906361e-03
## ASV0077     -2.651152e-04 -2.530594e-04 -2.391734e-04 -2.125052e-04
## ASV0625      4.887694e-03  5.050564e-03  5.216889e-03  5.358426e-03
## ASV2464      2.247817e-03  2.319755e-03  2.393138e-03  2.455418e-03
## ASV1315      5.646891e-03  5.899376e-03  6.162217e-03  6.422191e-03
## ASV2673      4.289195e-03  4.490174e-03  4.700234e-03  4.914144e-03
## ASV2161      1.811279e-03  1.897759e-03  1.988238e-03  2.081989e-03
## ASV0337     -2.245224e-03 -2.328097e-03 -2.413271e-03 -2.482735e-03
## ASV7680     -2.896235e-03 -3.015803e-03 -3.139754e-03 -3.264646e-03
## ASV0611      6.744754e-03  7.043628e-03  7.354992e-03  7.665006e-03
## ASV3118     -2.223557e-03 -2.318110e-03 -2.416260e-03 -2.513506e-03
## ASV1284      2.345897e-03  2.446099e-03  2.550150e-03  2.668906e-03
## ASV0889      1.592951e-03  1.655270e-03  1.719779e-03  1.777065e-03
## ASV4649     -1.739722e-03 -1.809110e-03 -1.880877e-03 -1.953833e-03
## ASV1108     -2.685816e-03 -2.812498e-03 -2.944881e-03 -3.087826e-03
## ASV0738      6.954963e-04  7.650584e-04  8.398270e-04  9.426432e-04
## ASV0473      3.922176e-04  4.107336e-04  4.301178e-04  4.551012e-04
## ASV0598     -1.942669e-03 -1.998042e-03 -2.053923e-03 -2.086702e-03
## ASV0429      3.775175e-03  3.914073e-03  4.056831e-03  4.179514e-03
## ASV1549      4.830488e-03  5.057089e-03  5.293758e-03  5.539900e-03
## ASV1203      2.950403e-03  3.063432e-03  3.179915e-03  3.292417e-03
## ASV4532      4.600780e-05  4.694626e-05  4.807551e-05  4.684646e-05
## ASV0274     -2.417014e-03 -2.489748e-03 -2.563574e-03 -2.610105e-03
## ASV0163     -3.365404e-03 -3.462321e-03 -3.560316e-03 -3.638962e-03
## ASV1298      1.405680e-03  1.450301e-03  1.495983e-03  1.539732e-03
## ASV9424     -3.974910e-03 -4.145196e-03 -4.322206e-03 -4.508048e-03
## ASV0412      5.490408e-03  5.700488e-03  5.917121e-03  6.108990e-03
## ASV0284      2.094501e-03  2.160178e-03  2.226926e-03  2.280128e-03
## ASV0620     -2.296830e-03 -2.402592e-03 -2.512794e-03 -2.632904e-03
## ASV0153     -4.467425e-03 -4.663830e-03 -4.867961e-03 -5.053328e-03
## ASV0498      1.142341e-03  1.211989e-03  1.285193e-03  1.374589e-03
## ASV0097      3.362308e-03  3.519136e-03  3.682977e-03  3.857998e-03
## ASV0104     -1.293300e-02 -1.343724e-02 -1.395770e-02 -1.440612e-02
## ASV1282      2.402252e-03  2.500552e-03  2.602164e-03  2.692747e-03
## ASV3883     -1.539944e-03 -1.607877e-03 -1.678358e-03 -1.755078e-03
## ASV0801      1.692933e-03  1.774529e-03  1.859849e-03  1.960766e-03
## ASV1611     -5.411063e-03 -5.641177e-03 -5.880129e-03 -6.127147e-03
## ASV0227     -2.391904e-03 -2.508484e-03 -2.630396e-03 -2.753599e-03
## ASV0833      2.524314e-03  2.644536e-03  2.769962e-03  2.898222e-03
## ASV0718      4.824510e-03  5.020384e-03  5.223046e-03  5.417873e-03
## ASV1139      1.084513e-03  1.100586e-03  1.115319e-03  1.120820e-03
## ASV0766     -1.111542e-03 -1.148941e-03 -1.187210e-03 -1.225335e-03
## ASV2091      5.387079e-03  5.565619e-03  5.747993e-03  5.891669e-03
## ASV1238      1.263676e-04  1.518017e-04  1.793502e-04  2.135469e-04
## ASV9193     -1.006532e-03 -1.063086e-03 -1.122544e-03 -1.206229e-03
## ASV0290     -7.800974e-04 -8.173918e-04 -8.559834e-04 -9.006540e-04
## ASV0231      4.885161e-03  5.074902e-03  5.270705e-03  5.460895e-03
## ASV0185      2.562343e-03  2.735324e-03  2.919229e-03  3.149437e-03
## ASV2330      1.266980e-03  1.310947e-03  1.356058e-03  1.389025e-03
## ASV3119     -2.329237e-03 -2.450328e-03 -2.577477e-03 -2.721911e-03
## ASV2368     -2.685578e-03 -2.811696e-03 -2.943643e-03 -3.098034e-03
## ASV0122     -1.467983e-03 -1.514412e-03 -1.561733e-03 -1.585148e-03
## ASV1044      3.908000e-03  4.095349e-03  4.291204e-03  4.495219e-03
## ASV0160     -3.365795e-03 -3.458611e-03 -3.552062e-03 -3.610441e-03
## ASV0326      2.921997e-03  3.038705e-03  3.159230e-03  3.253897e-03
## ASV1388      4.978842e-03  5.175225e-03  5.378198e-03  5.559574e-03
## ASV0792      5.234478e-03  5.422188e-03  5.614723e-03  5.792762e-03
## ASV0036     -3.918789e-03 -4.085190e-03 -4.257640e-03 -4.410214e-03
## ASV2125      5.785740e-03  6.010700e-03  6.242763e-03  6.450159e-03
## ASV1075      1.348958e-03  1.412313e-03  1.478495e-03  1.542987e-03
## ASV0390      1.696633e-03  1.791368e-03  1.891428e-03  2.011635e-03
## ASV3790     -4.981927e-03 -5.190594e-03 -5.407030e-03 -5.626740e-03
## ASV1535     -6.315380e-04 -6.673223e-04 -7.050481e-04 -7.546084e-04
## ASV0263      1.007231e-03  1.048635e-03  1.091547e-03  1.141778e-03
## ASV0675      8.865356e-03  9.264104e-03  9.679500e-03  1.011131e-02
## ASV3348      1.030097e-03  1.083636e-03  1.139908e-03  1.188814e-03
## ASV0058     -7.106344e-03 -7.373390e-03 -7.648131e-03 -7.886968e-03
## ASV4142      1.712375e-03  1.773641e-03  1.836527e-03  1.892048e-03
## ASV0059     -6.042431e-03 -6.265336e-03 -6.494320e-03 -6.696242e-03
## ASV0013     -1.313657e-02 -1.365022e-02 -1.418059e-02 -1.465836e-02
## ASV0033     -4.329979e-03 -4.517295e-03 -4.711752e-03 -4.897429e-03
## ASV4354     -1.537959e-03 -1.594614e-03 -1.653053e-03 -1.709971e-03
## ASV0022     -4.509253e-03 -4.701348e-03 -4.900503e-03 -5.093572e-03
## ASV0134     -1.346067e-03 -1.412416e-03 -1.481922e-03 -1.554873e-03
## ASV0415     -2.949101e-04 -2.864886e-04 -2.766633e-04 -2.540282e-04
## ASV10103    -3.049450e-03 -3.176585e-03 -3.308355e-03 -3.449650e-03
## ASV1613      4.263188e-03  4.413825e-03  4.568105e-03  4.701277e-03
## ASV0135      5.930476e-04  6.529162e-04  7.174171e-04  8.009218e-04
## ASV0469     -5.311360e-03 -5.503426e-03 -5.700910e-03 -5.885275e-03
## ASV0471      3.803370e-03  3.958790e-03  4.119847e-03  4.280401e-03
## ASV0451     -1.394913e-03 -1.465623e-03 -1.539698e-03 -1.613382e-03
## ASV0747      1.854100e-03  1.942894e-03  2.035526e-03  2.131846e-03
## ASV1314     -2.837041e-03 -2.979291e-03 -3.128688e-03 -3.297003e-03
## ASV0425     -5.551851e-03 -5.730065e-03 -5.911593e-03 -6.056502e-03
## ASV0559     -3.258691e-03 -3.373916e-03 -3.492644e-03 -3.602882e-03
## ASV0148     -3.275310e-03 -3.371128e-03 -3.467753e-03 -3.535306e-03
## ASV0129     -1.131183e-03 -1.138258e-03 -1.142931e-03 -1.119980e-03
## ASV1072      1.504707e-03  1.544303e-03  1.583852e-03  1.608189e-03
## ASV2390      1.057948e-03  1.084175e-03  1.110141e-03  1.119552e-03
## ASV0548      4.481575e-03  4.668086e-03  4.861430e-03  5.041613e-03
## ASV0168     -6.002430e-03 -6.225427e-03 -6.455101e-03 -6.666779e-03
## ASV0066     -4.543660e-03 -4.713054e-03 -4.887221e-03 -5.038967e-03
## ASV0468     -1.791603e-03 -1.865153e-03 -1.941478e-03 -2.025210e-03
## ASV0172     -1.664538e-04 -1.392964e-04 -1.089768e-04 -5.983648e-05
## ASV0236     -1.338006e-03 -1.345728e-03 -1.350781e-03 -1.333961e-03
## ASV0250      1.474706e-03  1.590553e-03  1.714372e-03  1.867470e-03
## ASV0338      2.602527e-04  2.910138e-04  3.238310e-04  3.597562e-04
## ASV0450     -1.480359e-05 -1.590688e-05 -1.720223e-05 -1.684725e-05
## ASV0377      5.218261e-03  5.423671e-03  5.635728e-03  5.839020e-03
## ASV1022      1.553153e-03  1.620354e-03  1.690336e-03  1.769069e-03
## ASV6174     -3.276083e-04 -3.406800e-04 -3.542783e-04 -3.719783e-04
## ASV0786      4.118708e-04  4.220772e-04  4.322793e-04  4.421916e-04
## ASV0053     -6.371894e-03 -6.626806e-03 -6.890323e-03 -7.140194e-03
## ASV0697     -1.389251e-03 -1.427768e-03 -1.466541e-03 -1.495445e-03
## ASV0785      4.710742e-03  4.898670e-03  5.093026e-03  5.275679e-03
## ASV1967     -2.640743e-03 -2.729823e-03 -2.821014e-03 -2.898336e-03
## ASV0385     -1.048030e-03 -1.074864e-03 -1.101747e-03 -1.119034e-03
## ASV0295      7.486359e-04  8.105178e-04  8.768299e-04  9.585234e-04
## ASV0072     -4.234302e-03 -4.367773e-03 -4.503213e-03 -4.613165e-03
## ASV0157     -1.361790e-03 -1.381841e-03 -1.399857e-03 -1.395353e-03
## ASV0501      2.814906e-03  2.947901e-03  3.086744e-03  3.233976e-03
## ASV10729    -4.026034e-03 -4.192562e-03 -4.365049e-03 -4.539728e-03
## ASV1470      1.599566e-03  1.653124e-03  1.707741e-03  1.753583e-03
## ASV0050     -1.198783e-02 -1.243802e-02 -1.290148e-02 -1.333208e-02
## ASV0411      6.710224e-06  2.051561e-05  3.564478e-05  5.765573e-05
## ASV0549      2.874336e-03  3.009715e-03  3.151196e-03  3.292304e-03
## ASV0184      1.515149e-03  1.579486e-03  1.646448e-03  1.719445e-03
## ASV0705      1.939430e-03  2.020738e-03  2.104843e-03  2.186846e-03
## ASV1715      4.614789e-03  4.804670e-03  5.001427e-03  5.199986e-03
## ASV0603      6.924906e-04  7.291822e-04  7.679809e-04  8.159578e-04
## ASV0826      1.229492e-03  1.267716e-03  1.306540e-03  1.336316e-03
## ASV0034     -5.092157e-03 -5.267446e-03 -5.446609e-03 -5.610270e-03
## ASV0838      1.059259e-03  1.092635e-03  1.126272e-03  1.160411e-03
## ASV0614     -3.002097e-03 -3.111233e-03 -3.223262e-03 -3.325491e-03
## ASV0014     -1.171367e-02 -1.215850e-02 -1.261688e-02 -1.306128e-02
## ASV0585     -8.219583e-04 -8.557151e-04 -8.905548e-04 -9.226341e-04
## ASV0016     -1.201231e-02 -1.247010e-02 -1.294195e-02 -1.341357e-02
## ASV5394     -3.269610e-03 -3.402232e-03 -3.539329e-03 -3.670967e-03
## ASV0666      2.558372e-03  2.653866e-03  2.752094e-03  2.850828e-03
## ASV2085      3.200119e-04  3.053556e-04  2.885785e-04  2.641236e-04
## ASV0003     -1.083425e-02 -1.124098e-02 -1.165981e-02 -1.208962e-02
## ASV0346      5.465890e-04  5.967981e-04  6.503901e-04  7.037309e-04
## ASV0267     -1.274889e-03 -1.303914e-03 -1.332564e-03 -1.363732e-03
## ASV0353      3.272133e-03  3.436695e-03  3.609154e-03  3.793480e-03
## ASV2419      2.990814e-03  3.101278e-03  3.214969e-03  3.325835e-03
## ASV0447      2.367802e-03  2.493146e-03  2.624588e-03  2.760617e-03
## ASV0654      5.294131e-03  5.512677e-03  5.738750e-03  5.958101e-03
## ASV0151      1.420352e-03  1.505812e-03  1.596317e-03  1.688497e-03
## ASV0065     -4.421241e-03 -4.587345e-03 -4.758217e-03 -4.916727e-03
## ASV0527      3.256096e-03  3.381802e-03  3.511436e-03  3.642207e-03
## ASV4055     -1.564884e-03 -1.642792e-03 -1.724677e-03 -1.811807e-03
## ASV0166     -3.299319e-03 -3.409477e-03 -3.522015e-03 -3.629444e-03
## ASV0417     -3.022040e-03 -3.134436e-03 -3.250209e-03 -3.364433e-03
## ASV0078     -2.125504e-03 -2.187176e-03 -2.249069e-03 -2.300987e-03
## ASV0322     -2.623660e-03 -2.704168e-03 -2.785669e-03 -2.863322e-03
## ASV0156     -3.762215e-03 -3.899369e-03 -4.040453e-03 -4.180778e-03
## ASV0648     -4.026249e-03 -4.198991e-03 -4.378411e-03 -4.566028e-03
## ASV0407      5.318176e-04  5.634472e-04  5.968900e-04  6.334139e-04
## ASV2030     -5.854755e-04 -6.048859e-04 -6.250431e-04 -6.440390e-04
## ASV0300      2.811732e-03  2.947962e-03  3.090280e-03  3.235270e-03
## ASV1150     -2.288738e-05 -1.257682e-05 -1.120465e-06  9.431794e-06
## ASV0958      3.029546e-03  3.185249e-03  3.348996e-03  3.527234e-03
## ASV0216     -3.355040e-03 -3.471242e-03 -3.590697e-03 -3.713472e-03
## ASV0446      6.315666e-03  6.599494e-03  6.894857e-03  7.199439e-03
## ASV0367     -1.807686e-03 -1.877865e-03 -1.950355e-03 -2.023681e-03
## ASV0200     -3.537049e-03 -3.681645e-03 -3.831488e-03 -3.980140e-03
## ASV0334     -8.676312e-04 -8.686323e-04 -8.677856e-04 -8.680712e-04
## ASV1311      2.259740e-03  2.340964e-03  2.424265e-03  2.515462e-03
## ASV0458      2.587193e-03  2.689189e-03  2.794651e-03  2.897522e-03
## ASV1371      1.177153e-04  1.236979e-04  1.299399e-04  1.358677e-04
## ASV0418      3.291028e-03  3.426013e-03  3.565983e-03  3.712459e-03
## ASV0004      3.780636e-03  3.928457e-03  4.081074e-03  4.219115e-03
## ASV1943      2.587884e-03  2.684248e-03  2.783525e-03  2.871288e-03
## ASV1495     -1.256755e-03 -1.331099e-03 -1.409725e-03 -1.490276e-03
## ASV0901     -4.909865e-03 -5.129195e-03 -5.357757e-03 -5.586776e-03
## ASV0628      2.207864e-03  2.279057e-03  2.351291e-03  2.420737e-03
## ASV0400      8.841539e-04  9.120632e-04  9.402611e-04  9.667999e-04
## ASV0116     -4.014075e-03 -4.201084e-03 -4.396346e-03 -4.598795e-03
## ASV0788      2.837212e-03  2.952128e-03  3.071007e-03  3.189398e-03
## ASV0117      2.302208e-03  2.416081e-03  2.535420e-03  2.661988e-03
## ASV3137      4.383024e-04  4.541130e-04  4.704043e-04  4.839299e-04
## ASV0001      3.878191e-03  4.003265e-03  4.130641e-03  4.252576e-03
## ASV1651      2.640410e-03  2.730967e-03  2.823889e-03  2.918363e-03
## ASV1692      3.867714e-03  4.045618e-03  4.231173e-03  4.421419e-03
## ASV0660      1.267300e-03  1.289377e-03  1.309994e-03  1.330940e-03
## ASV0508      6.643855e-05  6.435451e-05  6.200399e-05  5.520990e-05
## ASV1660     -1.675470e-03 -1.753330e-03 -1.834405e-03 -1.916095e-03
## ASV0233      1.013505e-03  1.066396e-03  1.122084e-03  1.181078e-03
## ASV1343     -3.517354e-03 -3.667024e-03 -3.822514e-03 -3.980105e-03
## ASV0209      2.515066e-03  2.595295e-03  2.677080e-03  2.760234e-03
## ASV0193     -3.534064e-03 -3.658337e-03 -3.785860e-03 -3.920438e-03
## ASV0357      3.460263e-04  3.864456e-04  4.303150e-04  4.817655e-04
## ASV0198      9.397420e-04  9.821031e-04  1.026386e-03  1.072783e-03
## ASV0007      3.677181e-03  3.795857e-03  3.916727e-03  4.035876e-03
## ASV1772     -3.480489e-04 -3.550092e-04 -3.614342e-04 -3.645450e-04
## ASV0009      3.425939e-03  3.534616e-03  3.645162e-03  3.757261e-03
## ASV0006      9.237675e-04  9.318695e-04  9.384348e-04  9.432938e-04
## ASV0011     -5.025175e-03 -5.242145e-03 -5.467638e-03 -5.702757e-03
## ASV0015      3.185595e-03  3.309473e-03  3.437236e-03  3.557306e-03
## ASV0017      3.348540e-03  3.478439e-03  3.612448e-03  3.744192e-03
## ASV0235     -2.872768e-03 -2.993091e-03 -3.117826e-03 -3.245743e-03
## ASV0382      1.117330e-03  1.181922e-03  1.249517e-03  1.314547e-03
## ASV2357      4.317488e-03  4.500165e-03  4.689951e-03  4.886995e-03
## ASV0567     -2.835389e-03 -2.946860e-03 -3.062390e-03 -3.184842e-03
## ASV0165      3.248376e-03  3.377187e-03  3.510313e-03  3.644484e-03
## ASV0005      6.044974e-03  6.261762e-03  6.484034e-03  6.704884e-03
## ASV0384      2.114914e-04  2.447315e-04  2.811291e-04  3.227708e-04
## ASV0002      1.796280e-03  1.885079e-03  1.978158e-03  2.069290e-03
## ASV3017      3.395767e-03  3.514507e-03  3.636271e-03  3.759049e-03
## ASV0091      1.669163e-03  1.742898e-03  1.819533e-03  1.900192e-03
## ASV0186     -4.101238e-03 -4.267891e-03 -4.440131e-03 -4.618784e-03
## ASV0370      5.348559e-04  5.628074e-04  5.923142e-04  6.284484e-04
## ASV0018      6.394223e-03  6.628328e-03  6.868767e-03  7.113996e-03
## ASV1377      5.551295e-03  5.756142e-03  5.966892e-03  6.182863e-03
## ASV0019      6.414928e-03  6.650478e-03  6.892466e-03  7.146913e-03
## ASV0023     -2.399111e-04 -2.767531e-04 -3.165109e-04 -3.477745e-04
## ASV2194      2.556072e-03  2.672550e-03  2.794085e-03  2.918516e-03
## ASV1155      1.242310e-04  1.444533e-04  1.663133e-04  1.761614e-04
## ASV0510     -1.694667e-03 -1.732211e-03 -1.769335e-03 -1.816462e-03
## ASV2371     -1.985336e-03 -2.047789e-03 -2.111379e-03 -2.166899e-03
## ASV0024     -5.737642e-04 -6.241077e-04 -6.778399e-04 -7.252313e-04
## ASV2452      2.641952e-03  2.722801e-03  2.804733e-03  2.892647e-03
## ASV2332      7.771856e-04  8.292619e-04  8.843097e-04  9.507513e-04
## ASV2591      7.382077e-04  7.866110e-04  8.376279e-04  9.008623e-04
## ASV0521      5.025574e-03  5.252338e-03  5.488677e-03  5.734873e-03
## ASV5542      1.646459e-03  1.721101e-03  1.798761e-03  1.888920e-03
## ASV0336     -2.007715e-03 -2.086183e-03 -2.167299e-03 -2.253800e-03
## ASV10102     3.276132e-03  3.413670e-03  3.556163e-03  3.708091e-03
## ASV16823    -1.860684e-03 -1.917709e-03 -1.975767e-03 -2.020124e-03
## ASV3104      1.859482e-03  1.916437e-03  1.974424e-03  2.020038e-03
## ASV0781      1.051851e-03  1.089631e-03  1.128482e-03  1.172881e-03
## ASV10899     1.745789e-03  1.839337e-03  1.937623e-03  2.047381e-03
## ASV11222    -1.859321e-03 -1.916299e-03 -1.974312e-03 -2.019944e-03
## ASV11327    -1.858120e-03 -1.915028e-03 -1.972970e-03 -2.019883e-03
## ASV12458    -1.856920e-03 -1.913759e-03 -1.971629e-03 -2.019830e-03
## ASV1636     -1.458925e-03 -1.500678e-03 -1.543012e-03 -1.584539e-03
## ASV1890     -2.005435e-03 -2.075537e-03 -2.147728e-03 -2.214441e-03
## ASV2898      4.723425e-03  4.894230e-03  5.069714e-03  5.252456e-03
## ASV8328      3.386860e-04  3.794472e-04  4.233303e-04  4.778423e-04
## ASV0709     -3.912406e-03 -4.054795e-03 -4.201066e-03 -4.356767e-03
## ASV0856      9.441650e-04  9.918497e-04  1.041785e-03  1.097501e-03
## ASV0909     -8.570619e-04 -8.568079e-04 -8.544622e-04 -8.560527e-04
## ASV0937     -3.532309e-03 -3.687154e-03 -3.848551e-03 -4.008368e-03
## ASV11390    -1.854652e-03 -1.911366e-03 -1.969105e-03 -2.019700e-03
## ASV11966     1.638685e-03  1.718414e-03  1.801687e-03  1.892624e-03
## ASV12990     6.718876e-04  6.980201e-04  7.249646e-04  7.588076e-04
## ASV14797     2.098441e-03  2.167854e-03  2.238817e-03  2.317991e-03
## ASV14904    -1.854918e-03 -1.911673e-03 -1.969457e-03 -2.019640e-03
## ASV15304     1.124859e-03  1.185905e-03  1.249943e-03  1.323978e-03
## ASV16696    -1.854446e-03 -1.911197e-03 -1.968979e-03 -2.019625e-03
## ASV1690      1.745265e-03  1.829609e-03  1.917436e-03  2.009093e-03
## ASV2029      6.327166e-03  6.568336e-03  6.817046e-03  7.079068e-03
## ASV2834      3.667741e-03  3.819298e-03  3.976379e-03  4.139728e-03
## ASV4003      1.767021e-03  1.866945e-03  1.972338e-03  2.089278e-03
## ASV4064      2.719614e-03  2.835073e-03  2.954786e-03  3.084726e-03
## ASV4294      1.429042e-03  1.508369e-03  1.591932e-03  1.684614e-03
## ASV4609      4.944126e-05  5.638379e-05  6.388537e-05  8.317475e-05
## ASV6283     -1.856666e-03 -1.913660e-03 -1.971708e-03 -2.019611e-03
## ASV6491     -1.855465e-03 -1.912389e-03 -1.970365e-03 -2.019622e-03
## ASV7453      1.513096e-03  1.593398e-03  1.677610e-03  1.772891e-03
## ASV7959      7.318861e-04  7.801220e-04  8.311542e-04  8.958349e-04
## ASV8219      1.855770e-03  1.912766e-03  1.970821e-03  2.019659e-03
## ASV8547     -1.854569e-03 -1.911495e-03 -1.969478e-03 -2.019685e-03
## ASV9319      1.870086e-03  1.954625e-03  2.042805e-03  2.142966e-03
## ASV9382     -1.854316e-03 -1.911252e-03 -1.969247e-03 -2.019721e-03
## ASV11516    -1.853117e-03 -1.909982e-03 -1.967905e-03 -2.019755e-03
## ASV14377    -1.851918e-03 -1.908714e-03 -1.966564e-03 -2.019790e-03
## ASV1867      3.792078e-03  3.953168e-03  4.120341e-03  4.297384e-03
## ASV1895     -6.047687e-04 -6.238480e-04 -6.434898e-04 -6.650911e-04
## ASV3168      1.237545e-03  1.274257e-03  1.311288e-03  1.354315e-03
## ASV4449      2.575040e-03  2.666502e-03  2.760642e-03  2.852699e-03
## ASV6596      2.384934e-03  2.507280e-03  2.635713e-03  2.772422e-03
## ASV7492     -2.362728e-04 -2.234705e-04 -2.089631e-04 -1.903759e-04
## ASV9854     -8.720491e-04 -8.962278e-04 -9.207106e-04 -9.391998e-04
## ASV6296      1.850423e-03  1.907174e-03  1.964980e-03  2.019930e-03
## ASV4201      1.626870e-03  1.723211e-03  1.824892e-03  1.933466e-03
## ASV0552      6.430501e-03  6.706364e-03  6.992639e-03  7.288423e-03
## ASV3671     -5.854935e-05 -4.875188e-05 -3.815221e-05 -2.157526e-05
## ASV3529      6.683173e-05  8.725450e-05  1.091821e-04  1.353769e-04
## ASV1060      1.735109e-03  1.817682e-03  1.904269e-03  1.993750e-03
## ASV0239     -2.571128e-03 -2.644615e-03 -2.718802e-03 -2.797091e-03
## ASV5711     -2.623121e-03 -2.714063e-03 -2.807428e-03 -2.898888e-03
## ASV4152     -3.813706e-03 -3.957995e-03 -4.106748e-03 -4.258760e-03
## ASV1461      2.892617e-03  2.980617e-03  3.069995e-03  3.171177e-03
## ASV2877      2.718625e-03  2.815715e-03  2.915223e-03  3.021192e-03
## ASV0012      2.685555e-03  2.811741e-03  2.943531e-03  3.074038e-03
## ASV9823      5.099216e-04  5.182064e-04  5.259743e-04  5.382909e-04
## ASV0008      2.841633e-03  2.972629e-03  3.109340e-03  3.249643e-03
## ASV7832     -2.273010e-03 -2.357914e-03 -2.445496e-03 -2.533534e-03
## ASV1915      4.243453e-04  4.463219e-04  4.690939e-04  4.906894e-04
## ASV0055      1.657227e-03  1.719186e-03  1.782822e-03  1.847157e-03
## ASV0032      3.685225e-03  3.814456e-03  3.947050e-03  4.090151e-03
## ASV2977     -3.192932e-03 -3.312579e-03 -3.435813e-03 -3.564837e-03
## ASV0466      2.888690e-03  2.982099e-03  3.077278e-03  3.181054e-03
## ASV3866      3.917985e-03  4.085929e-03  4.260572e-03  4.445703e-03
## ASV0040      5.450747e-03  5.691771e-03  5.942576e-03  6.207295e-03
## ASV0496     -8.827991e-04 -9.420167e-04 -1.004797e-03 -1.067658e-03
## ASV0052      5.577678e-03  5.784595e-03  5.997365e-03  6.222931e-03
## ASV3828     -3.405647e-03 -3.537382e-03 -3.673697e-03 -3.817398e-03
## ASV1930      2.227105e-03  2.310598e-03  2.396362e-03  2.484316e-03
## ASV2126      3.560060e-03  3.695652e-03  3.835385e-03  3.985032e-03
## ASV0793      2.884526e-03  3.024191e-03  3.170119e-03  3.320137e-03
## ASV0299     -9.937485e-04 -1.017079e-03 -1.040622e-03 -1.070018e-03
## ASV0208      4.073196e-03  4.262845e-03  4.461001e-03  4.666538e-03
## ASV0511     -1.056638e-03 -1.068505e-03 -1.079046e-03 -1.098603e-03
## ASV1123     -1.860046e-03 -1.912363e-03 -1.965188e-03 -2.026221e-03
## ASV0099     -1.076993e-03 -1.103107e-03 -1.128505e-03 -1.156074e-03
## ASV0752     -5.304804e-04 -5.591590e-04 -5.891801e-04 -6.214916e-04
## ASV0883      2.029496e-04  2.165096e-04  2.308222e-04  2.503997e-04
## ASV0683      3.546548e-03  3.706124e-03  3.872334e-03  4.044117e-03
## ASV4117     -3.450976e-03 -3.584266e-03 -3.722058e-03 -3.866476e-03
## ASV2172      1.409191e-03  1.467117e-03  1.527183e-03  1.591413e-03
## ASV0330     -2.573164e-03 -2.678270e-03 -2.787081e-03 -2.900764e-03
## ASV0728      2.724047e-03  2.844414e-03  2.969526e-03  3.102088e-03
## ASV0499      5.430416e-03  5.680824e-03  5.942239e-03  6.213789e-03
## ASV0120     -5.048093e-03 -5.241092e-03 -5.439820e-03 -5.651353e-03
## ASV1446     -4.886276e-05 -7.006100e-05 -9.338871e-05 -1.195601e-04
## ASV17171    -3.352265e-03 -3.485205e-03 -3.622916e-03 -3.767133e-03
## ASV0533      1.242125e-03  1.302662e-03  1.366064e-03  1.429076e-03
## ASV2495     -1.683551e-03 -1.765080e-03 -1.850539e-03 -1.937481e-03
## ASV5582      8.153196e-04  8.325479e-04  8.494634e-04  8.724126e-04
## ASV1488      1.314174e-03  1.372732e-03  1.433556e-03  1.499509e-03
## ASV0682      3.749061e-03  3.919687e-03  4.097569e-03  4.282375e-03
## ASV0068     -6.410368e-04 -6.815896e-04 -7.242428e-04 -7.678767e-04
## ASV1987     -2.356586e-03 -2.474332e-03 -2.597727e-03 -2.727202e-03
## ASV0035     -3.133806e-04 -3.686781e-04 -4.292530e-04 -4.900974e-04
## ASV7192     -1.891442e-03 -1.949943e-03 -2.009320e-03 -2.070596e-03
## ASV0873     -2.317562e-06 -1.260472e-05 -2.367175e-05 -3.537339e-05
## ASV4749     -5.904188e-04 -6.458025e-04 -7.052215e-04 -7.629319e-04
## ASV2174      1.700802e-03  1.751649e-03  1.803480e-03  1.864154e-03
## ASV1476     -2.079397e-03 -2.171121e-03 -2.266720e-03 -2.365274e-03
## ASV0740     -5.360530e-03 -5.600691e-03 -5.850832e-03 -6.110436e-03
## ASV0170      1.032579e-03  1.075863e-03  1.120821e-03  1.166845e-03
## ASV2466     -4.327039e-03 -4.506255e-03 -4.692358e-03 -4.889772e-03
## ASV1709      3.148285e-03  3.268188e-03  3.391828e-03  3.523739e-03
## ASV6170     -3.261036e-03 -3.399071e-03 -3.542310e-03 -3.689010e-03
## ASV3673      3.759005e-03  3.919192e-03  4.085495e-03  4.259050e-03
## ASV1745      2.910381e-04  3.028139e-04  3.149374e-04  3.279686e-04
##                                                                    
## (Intercept) -1.910857e-03 -2.089692e-03 -2.282404e-03 -2.489773e-03
## ASV1236      2.452292e-03  2.532113e-03  2.613575e-03  2.696807e-03
## ASV0421     -4.482538e-03 -4.630664e-03 -4.782130e-03 -4.936888e-03
## ASV0691     -3.382001e-03 -3.478618e-03 -3.576795e-03 -3.676485e-03
## ASV0899      2.302457e-04  2.437439e-04  2.575147e-04  2.715778e-04
## ASV1004      5.082827e-03  5.248474e-03  5.417464e-03  5.589770e-03
## ASV1041     -3.401490e-03 -3.508331e-03 -3.616856e-03 -3.727048e-03
## ASV1058      4.814791e-03  4.978444e-03  5.146130e-03  5.317872e-03
## ASV12542     1.213155e-03  1.246106e-03  1.279557e-03  1.313453e-03
## ASV1294      5.864518e-03  6.072735e-03  6.286470e-03  6.505821e-03
## ASV13113     2.827575e-03  2.960157e-03  3.098756e-03  3.243573e-03
## ASV1318      4.860183e-03  5.022896e-03  5.189218e-03  5.359250e-03
## ASV2269     -1.439021e-03 -1.485989e-03 -1.533774e-03 -1.582488e-03
## ASV2542      4.045919e-03  4.221439e-03  4.403864e-03  4.593454e-03
## ASV2660     -2.605197e-03 -2.685531e-03 -2.767231e-03 -2.850384e-03
## ASV2737     -3.109338e-04 -3.256391e-04 -3.407157e-04 -3.562573e-04
## ASV2840      3.311532e-03  3.405353e-03  3.500178e-03  3.595926e-03
## ASV3053      1.582895e-04  1.634516e-04  1.689171e-04  1.746258e-04
## ASV3077      1.124130e-03  1.161904e-03  1.200722e-03  1.240551e-03
## ASV3134      5.532164e-03  5.786395e-03  6.051846e-03  6.328923e-03
## ASV3140      2.177815e-03  2.265953e-03  2.356988e-03  2.451042e-03
## ASV3579      1.395883e-03  1.472370e-03  1.552784e-03  1.637216e-03
## ASV6119     -1.438573e-03 -1.485432e-03 -1.533162e-03 -1.581818e-03
## ASV7557     -1.438519e-03 -1.485363e-03 -1.533087e-03 -1.581737e-03
## ASV8422      6.947230e-04  7.159539e-04  7.377114e-04  7.599712e-04
## ASV1086     -3.548292e-04 -3.664649e-04 -3.784918e-04 -3.909024e-04
## ASV1310      2.883825e-03  2.982517e-03  3.083322e-03  3.186190e-03
## ASV15750    -5.931911e-04 -6.083422e-04 -6.234495e-04 -6.385172e-04
## ASV16905    -1.438407e-03 -1.485212e-03 -1.532932e-03 -1.581578e-03
## ASV2033      3.606641e-03  3.762851e-03  3.924967e-03  4.093131e-03
## ASV2089      9.981597e-04  1.030598e-03  1.063642e-03  1.097286e-03
## ASV2127      4.063918e-03  4.204556e-03  4.348721e-03  4.496438e-03
## ASV2725      4.125107e-03  4.249946e-03  4.376797e-03  4.505623e-03
## ASV2804     -1.438369e-03 -1.485152e-03 -1.532875e-03 -1.581526e-03
## ASV3075      3.228543e-03  3.358715e-03  3.493853e-03  3.634142e-03
## ASV3327      3.441321e-03  3.589731e-03  3.743865e-03  3.903902e-03
## ASV3342      3.486956e-03  3.627984e-03  3.773948e-03  3.924964e-03
## ASV3532     -3.168438e-03 -3.300064e-03 -3.436792e-03 -3.578795e-03
## ASV3600      3.923674e-03  4.081400e-03  4.244577e-03  4.413354e-03
## ASV4013      2.920636e-03  3.022944e-03  3.127753e-03  3.235073e-03
## ASV4136      2.692752e-03  2.782326e-03  2.874110e-03  2.968118e-03
## ASV4195      1.438363e-03  1.485123e-03  1.532857e-03  1.581522e-03
## ASV4407     -1.438367e-03 -1.485123e-03 -1.532861e-03 -1.581530e-03
## ASV4717     -6.378229e-05 -6.912427e-05 -7.469641e-05 -8.044579e-05
## ASV6794      1.320273e-03  1.362163e-03  1.405106e-03  1.449182e-03
## ASV8324     -1.438399e-03 -1.485149e-03 -1.532900e-03 -1.581584e-03
## ASV8981     -5.407839e-05 -4.049841e-05 -2.553779e-05 -9.051858e-06
## ASV9859      1.931833e-03  2.035864e-03  2.145420e-03  2.260820e-03
## ASV0936     -2.385309e-03 -2.470182e-03 -2.557266e-03 -2.646651e-03
## ASV12683    -3.564947e-04 -3.712375e-04 -3.864640e-04 -4.020932e-04
## ASV1293      3.301509e-03  3.410562e-03  3.522144e-03  3.636202e-03
## ASV13055    -2.282268e-04 -2.298029e-04 -2.310613e-04 -2.318858e-04
## ASV17063    -1.438511e-03 -1.485255e-03 -1.533037e-03 -1.581753e-03
## ASV2228      1.438535e-03  1.485279e-03  1.533066e-03  1.581788e-03
## ASV2769     -7.307925e-06  2.025361e-06  1.196391e-05  2.261255e-05
## ASV2803      5.506619e-04  5.658694e-04  5.812420e-04  5.968814e-04
## ASV2896      2.298885e-03  2.402962e-03  2.511823e-03  2.625782e-03
## ASV3062      1.101988e-03  1.162678e-03  1.226353e-03  1.293213e-03
## ASV3107      2.633415e-03  2.741782e-03  2.854065e-03  2.970452e-03
## ASV3265      4.251459e-03  4.389406e-03  4.530207e-03  4.673839e-03
## ASV3666     -1.835928e-04 -1.937480e-04 -2.045931e-04 -2.160529e-04
## ASV4497      1.037674e-03  1.073104e-03  1.109279e-03  1.146319e-03
## ASV6914     -6.036875e-04 -6.269888e-04 -6.511386e-04 -6.760315e-04
## ASV0576     -4.583669e-03 -4.720957e-03 -4.860679e-03 -5.002891e-03
## ASV0673      1.827164e-03  1.903433e-03  1.982112e-03  2.063224e-03
## ASV0772      1.764797e-03  1.834279e-03  1.906075e-03  1.980354e-03
## ASV0862     -8.990824e-04 -9.156466e-04 -9.316496e-04 -9.471468e-04
## ASV0898      1.857930e-03  1.941261e-03  2.027857e-03  2.117715e-03
## ASV0910      3.830614e-03  4.001922e-03  4.180074e-03  4.365319e-03
## ASV0964     -1.694308e-03 -1.744113e-03 -1.794467e-03 -1.845451e-03
## ASV10059     1.916751e-03  2.008708e-03  2.104761e-03  2.205174e-03
## ASV10263    -1.438841e-03 -1.485613e-03 -1.533465e-03 -1.582252e-03
## ASV1088      2.176873e-03  2.282723e-03  2.393592e-03  2.509686e-03
## ASV1101      2.632548e-03  2.720101e-03  2.809133e-03  2.899599e-03
## ASV1183      1.861303e-03  1.933337e-03  2.007826e-03  2.084688e-03
## ASV11956     4.379703e-04  4.479894e-04  4.579996e-04  4.681154e-04
## ASV12774    -3.433205e-04 -3.591792e-04 -3.758147e-04 -3.931193e-04
## ASV1321      1.310727e-03  1.382571e-03  1.457888e-03  1.536888e-03
## ASV13793    -1.438959e-03 -1.485748e-03 -1.533619e-03 -1.582425e-03
## ASV14482    -2.317457e-04 -2.409789e-04 -2.505145e-04 -2.602140e-04
## ASV15483     1.279660e-03  1.333698e-03  1.389620e-03  1.447597e-03
## ASV2062      7.050179e-03  7.312456e-03  7.582458e-03  7.860282e-03
## ASV2132      3.654975e-03  3.809056e-03  3.968797e-03  4.134434e-03
## ASV2413      4.237592e-03  4.386314e-03  4.538992e-03  4.695753e-03
## ASV2490      2.506400e-03  2.582612e-03  2.660119e-03  2.738882e-03
## ASV2594      1.821225e-03  1.901639e-03  1.985556e-03  2.073256e-03
## ASV2822     -1.439072e-03 -1.485880e-03 -1.533771e-03 -1.582596e-03
## ASV2863      2.468468e-03  2.550236e-03  2.634056e-03  2.719828e-03
## ASV2910      3.168006e-03  3.271089e-03  3.376349e-03  3.483906e-03
## ASV2980      1.117882e-03  1.151066e-03  1.184813e-03  1.218961e-03
## ASV3307      1.439157e-03  1.485982e-03  1.533888e-03  1.582725e-03
## ASV3474      3.171880e-03  3.314675e-03  3.463068e-03  3.617288e-03
## ASV3502      5.349807e-03  5.557158e-03  5.771370e-03  5.992676e-03
## ASV4236      2.213951e-03  2.281534e-03  2.350208e-03  2.420041e-03
## ASV4842     -8.062800e-04 -8.318340e-04 -8.578970e-04 -8.843160e-04
## ASV4894     -1.439228e-03 -1.486071e-03 -1.533989e-03 -1.582838e-03
## ASV5290      1.977414e-03  2.049543e-03  2.123477e-03  2.199275e-03
## ASV5501      4.224782e-04  4.425967e-04  4.636260e-04  4.857435e-04
## ASV5795      1.576873e-03  1.645092e-03  1.715784e-03  1.789117e-03
## ASV5987     -1.439296e-03 -1.486157e-03 -1.534086e-03 -1.582948e-03
## ASV6267     -1.439318e-03 -1.486186e-03 -1.534119e-03 -1.582984e-03
## ASV6862      2.480650e-03  2.555564e-03  2.631906e-03  2.709726e-03
## ASV7145      4.563976e-04  4.730242e-04  4.902505e-04  5.082094e-04
## ASV7673     -1.439365e-03 -1.486248e-03 -1.534190e-03 -1.583066e-03
## ASV7789      1.141499e-03  1.207578e-03  1.277166e-03  1.350520e-03
## ASV7809      1.048598e-04  1.201171e-04  1.363883e-04  1.538223e-04
## ASV8002     -1.439428e-03 -1.486332e-03 -1.534286e-03 -1.583175e-03
## ASV8205      1.020136e-03  1.063880e-03  1.109329e-03  1.156635e-03
## ASV9155     -1.041357e-03 -1.073290e-03 -1.105813e-03 -1.138809e-03
## ASV9221      1.949298e-04  2.180138e-04  2.427902e-04  2.694430e-04
## ASV9311     -1.439525e-03 -1.486462e-03 -1.534437e-03 -1.583349e-03
## ASV9557     -1.439553e-03 -1.486500e-03 -1.534482e-03 -1.583401e-03
## ASV9936     -1.439583e-03 -1.486540e-03 -1.534528e-03 -1.583455e-03
## ASV1445      4.126318e-03  4.298815e-03  4.477760e-03  4.663395e-03
## ASV4232      3.958164e-03  4.145416e-03  4.341370e-03  4.546460e-03
## ASV6479      5.641985e-04  6.087892e-04  6.562849e-04  7.069012e-04
## ASV0142     -6.991598e-03 -7.215522e-03 -7.444049e-03 -7.677205e-03
## ASV0378     -1.956824e-03 -2.002164e-03 -2.046987e-03 -2.091230e-03
## ASV1122      5.420710e-03  5.643141e-03  5.873386e-03  6.111678e-03
## ASV0123     -6.817125e-03 -7.033921e-03 -7.255047e-03 -7.480521e-03
## ASV2064      5.285845e-04  5.393685e-04  5.500118e-04  5.605718e-04
## ASV4459     -7.450714e-04 -7.682519e-04 -7.919617e-04 -8.161464e-04
## ASV0448      2.194797e-03  2.306889e-03  2.424293e-03  2.547155e-03
## ASV0397      3.832828e-03  3.982191e-03  4.136397e-03  4.295492e-03
## ASV0485      5.113595e-03  5.308593e-03  5.509997e-03  5.717929e-03
## ASV1566      4.447217e-03  4.618522e-03  4.795163e-03  4.977271e-03
## ASV1365      2.935397e-03  3.049548e-03  3.167164e-03  3.288319e-03
## ASV1065      6.001761e-03  6.238905e-03  6.484040e-03  6.737320e-03
## ASV0722     -4.998231e-05 -5.159079e-05 -5.337394e-05 -5.540662e-05
## ASV12660    -2.247074e-03 -2.317163e-03 -2.388622e-03 -2.461399e-03
## ASV0223     -7.997154e-06 -2.610028e-06  3.509640e-06  1.038552e-05
## ASV0229      2.951938e-03  3.079581e-03  3.212318e-03  3.350284e-03
## ASV0877     -6.478629e-04 -6.624875e-04 -6.772019e-04 -6.919877e-04
## ASV0983      4.964152e-03  5.141021e-03  5.322707e-03  5.509259e-03
## ASV0626     -9.373970e-04 -9.477577e-04 -9.572661e-04 -9.658719e-04
## ASV4146     -2.509871e-04 -2.614360e-04 -2.725739e-04 -2.844440e-04
## ASV4175     -3.298910e-03 -3.424593e-03 -3.554111e-03 -3.687495e-03
## ASV2082     -7.318401e-04 -7.817923e-04 -8.348949e-04 -8.913220e-04
## ASV2272      2.682632e-03  2.798851e-03  2.919633e-03  3.045130e-03
## ASV2245     -2.989825e-03 -3.108695e-03 -3.231591e-03 -3.358596e-03
## ASV0590     -2.460802e-03 -2.582032e-03 -2.708754e-03 -2.841167e-03
## ASV0217     -9.489934e-04 -9.269716e-04 -9.009575e-04 -8.707494e-04
## ASV0416      1.826644e-03  1.867608e-03  1.908149e-03  1.948165e-03
## ASV1056      3.880318e-03  4.051961e-03  4.230117e-03  4.414936e-03
## ASV7777     -2.929334e-03 -3.046932e-03 -3.168785e-03 -3.295034e-03
## ASV0455      7.370999e-04  7.676798e-04  7.990611e-04  8.312187e-04
## ASV0604      1.186040e-03  1.250324e-03  1.317665e-03  1.388164e-03
## ASV6100     -2.767164e-03 -2.881036e-03 -2.999228e-03 -3.121901e-03
## ASV11359    -2.849554e-03 -2.954322e-03 -3.061986e-03 -3.172578e-03
## ASV6604      2.409560e-03  2.515600e-03  2.625938e-03  2.740707e-03
## ASV5004     -1.684696e-03 -1.748903e-03 -1.815222e-03 -1.883734e-03
## ASV1483     -1.599944e-03 -1.661944e-03 -1.725956e-03 -1.792044e-03
## ASV9773     -3.483219e-03 -3.623221e-03 -3.768210e-03 -3.918360e-03
## ASV4059      7.108773e-04  7.529112e-04  7.971931e-04  8.437925e-04
## ASV1193      5.489185e-03  5.700635e-03  5.918799e-03  6.143806e-03
## ASV4610      9.931667e-05  1.192424e-04  1.404145e-04  1.628335e-04
## ASV0742     -1.118361e-03 -1.131127e-03 -1.142769e-03 -1.153248e-03
## ASV1502     -3.452072e-04 -3.689034e-04 -3.938921e-04 -4.202361e-04
## ASV0195     -9.718140e-04 -1.021021e-03 -1.072471e-03 -1.126231e-03
## ASV1213      1.243128e-03  1.272714e-03  1.302063e-03  1.331139e-03
## ASV1648     -2.551696e-03 -2.654686e-03 -2.761492e-03 -2.872287e-03
## ASV6984     -2.013682e-03 -2.099344e-03 -2.188494e-03 -2.281304e-03
## ASV0396     -9.955422e-05 -6.086145e-05 -1.877770e-05  2.683141e-05
## ASV4297      2.322906e-03  2.396528e-03  2.471669e-03  2.548328e-03
## ASV2622      5.637535e-03  5.829889e-03  6.027122e-03  6.229296e-03
## ASV3512      1.689198e-03  1.784650e-03  1.885429e-03  1.991775e-03
## ASV2411      2.666342e-03  2.785801e-03  2.910009e-03  3.039109e-03
## ASV2291     -9.724593e-04 -1.026190e-03 -1.082718e-03 -1.142113e-03
## ASV0807      3.522096e-03  3.688999e-03  3.862867e-03  4.043901e-03
## ASV1292      1.317292e-03  1.365722e-03  1.415731e-03  1.467403e-03
## ASV1035      4.859489e-04  5.011674e-04  5.168637e-04  5.330870e-04
## ASV0070     -6.025051e-04 -5.893208e-04 -5.732866e-04 -5.541822e-04
## ASV0255      5.362176e-04  5.487689e-04  5.606999e-04  5.719159e-04
## ASV0057     -5.042648e-03 -5.178406e-03 -5.314762e-03 -5.451508e-03
## ASV0077     -1.961142e-04 -1.760828e-04 -1.538730e-04 -1.293658e-04
## ASV0625      5.530076e-03  5.705278e-03  5.883738e-03  6.065431e-03
## ASV2464      2.529719e-03  2.606962e-03  2.685589e-03  2.765627e-03
## ASV1315      6.706227e-03  7.000957e-03  7.307336e-03  7.625682e-03
## ASV2673      5.143344e-03  5.382445e-03  5.632167e-03  5.892914e-03
## ASV2161      2.181770e-03  2.285344e-03  2.393653e-03  2.506862e-03
## ASV0337     -2.572557e-03 -2.663817e-03 -2.757459e-03 -2.853471e-03
## ASV7680     -3.396312e-03 -3.533718e-03 -3.675944e-03 -3.823167e-03
## ASV0611      8.002478e-03  8.353160e-03  8.718227e-03  9.098166e-03
## ASV3118     -2.617509e-03 -2.726409e-03 -2.839230e-03 -2.956118e-03
## ASV1284      2.780898e-03  2.897592e-03  3.018542e-03  3.143883e-03
## ASV0889      1.846486e-03  1.917753e-03  1.991561e-03  2.067980e-03
## ASV4649     -2.029393e-03 -2.108412e-03 -2.189993e-03 -2.274238e-03
## ASV1108     -3.231464e-03 -3.382317e-03 -3.539733e-03 -3.703987e-03
## ASV0738      1.028447e-03  1.121477e-03  1.220936e-03  1.327178e-03
## ASV0473      4.756834e-04  4.981263e-04  5.215653e-04  5.460690e-04
## ASV0598     -2.142503e-03 -2.198391e-03 -2.254496e-03 -2.310761e-03
## ASV0429      4.329711e-03  4.482907e-03  4.640066e-03  4.801199e-03
## ASV1549      5.797709e-03  6.066497e-03  6.346861e-03  6.639187e-03
## ASV1203      3.415192e-03  3.541874e-03  3.672144e-03  3.806067e-03
## ASV4532      4.945206e-05  5.156851e-05  5.411204e-05  5.711410e-05
## ASV0274     -2.686016e-03 -2.761753e-03 -2.838479e-03 -2.916154e-03
## ASV0163     -3.739168e-03 -3.839414e-03 -3.940485e-03 -4.042300e-03
## ASV1298      1.587156e-03  1.636404e-03  1.686880e-03  1.738669e-03
## ASV9424     -4.698452e-03 -4.897160e-03 -5.103519e-03 -5.317834e-03
## ASV0412      6.336390e-03  6.571423e-03  6.813354e-03  7.062313e-03
## ASV0284      2.347481e-03  2.416393e-03  2.486122e-03  2.556632e-03
## ASV0620     -2.751692e-03 -2.876158e-03 -3.005604e-03 -3.140210e-03
## ASV0153     -5.271846e-03 -5.498136e-03 -5.732861e-03 -5.976194e-03
## ASV0498      1.454411e-03  1.538997e-03  1.627443e-03  1.719848e-03
## ASV0097      4.035878e-03  4.222496e-03  4.417230e-03  4.620407e-03
## ASV0104     -1.495529e-02 -1.552044e-02 -1.610277e-02 -1.670256e-02
## ASV1282      2.800472e-03  2.911032e-03  3.025018e-03  3.142423e-03
## ASV3883     -1.830037e-03 -1.908517e-03 -1.989678e-03 -2.073586e-03
## ASV0801      2.054127e-03  2.152162e-03  2.254535e-03  2.361458e-03
## ASV1611     -6.383771e-03 -6.650778e-03 -6.927690e-03 -7.214831e-03
## ASV0227     -2.886977e-03 -3.025576e-03 -3.170332e-03 -3.321436e-03
## ASV0833      3.034620e-03  3.176146e-03  3.323525e-03  3.476895e-03
## ASV0718      5.633055e-03  5.855945e-03  6.086140e-03  6.323793e-03
## ASV1139      1.131988e-03  1.141675e-03  1.149404e-03  1.155048e-03
## ASV0766     -1.265265e-03 -1.306339e-03 -1.348312e-03 -1.391231e-03
## ASV2091      6.080689e-03  6.272468e-03  6.467972e-03  6.667175e-03
## ASV1238      2.457493e-04  2.799670e-04  3.166876e-04  3.559614e-04
## ASV9193     -1.272001e-03 -1.341823e-03 -1.414970e-03 -1.491568e-03
## ASV0290     -9.415447e-04 -9.839687e-04 -1.027568e-03 -1.072306e-03
## ASV0231      5.668093e-03  5.882146e-03  6.102645e-03  6.329715e-03
## ASV0185      3.357434e-03  3.579326e-03  3.814610e-03  4.063963e-03
## ASV2330      1.436237e-03  1.484105e-03  1.533191e-03  1.583499e-03
## ASV3119     -2.861581e-03 -3.009045e-03 -3.163642e-03 -3.325697e-03
## ASV2368     -3.243060e-03 -3.395386e-03 -3.554688e-03 -3.721308e-03
## ASV0122     -1.633679e-03 -1.682253e-03 -1.731692e-03 -1.781971e-03
## ASV1044      4.708649e-03  4.931646e-03  5.164471e-03  5.407469e-03
## ASV0160     -3.704284e-03 -3.797332e-03 -3.890601e-03 -3.983978e-03
## ASV0326      3.380694e-03  3.510844e-03  3.644942e-03  3.783001e-03
## ASV1388      5.775070e-03  5.996907e-03  6.225890e-03  6.462176e-03
## ASV0792      5.993972e-03  6.200105e-03  6.411032e-03  6.626762e-03
## ASV0036     -4.593489e-03 -4.782668e-03 -4.978238e-03 -5.180265e-03
## ASV2125      6.695327e-03  6.947268e-03  7.206650e-03  7.473547e-03
## ASV1075      1.615196e-03  1.690185e-03  1.768457e-03  1.850101e-03
## ASV0390      2.123679e-03  2.242398e-03  2.367672e-03  2.499854e-03
## ASV3790     -5.858503e-03 -6.099268e-03 -6.348658e-03 -6.606945e-03
## ASV1535     -7.964039e-04 -8.411129e-04 -8.881092e-04 -9.375069e-04
## ASV0263      1.187960e-03  1.236190e-03  1.286126e-03  1.337852e-03
## ASV0675      1.056108e-02  1.102949e-02  1.151684e-02  1.202373e-02
## ASV3348      1.250511e-03  1.314840e-03  1.382391e-03  1.453269e-03
## ASV0058     -8.175408e-03 -8.470772e-03 -8.773943e-03 -9.084936e-03
## ASV4142      1.958483e-03  2.025640e-03  2.094473e-03  2.164980e-03
## ASV0059     -6.936187e-03 -7.181440e-03 -7.432748e-03 -7.690082e-03
## ASV0013     -1.521994e-02 -1.579814e-02 -1.639425e-02 -1.700859e-02
## ASV0033     -5.105808e-03 -5.321485e-03 -5.544956e-03 -5.776359e-03
## ASV4354     -1.771723e-03 -1.835856e-03 -1.901964e-03 -1.970132e-03
## ASV0022     -5.306600e-03 -5.526796e-03 -5.754598e-03 -5.990104e-03
## ASV0134     -1.631417e-03 -1.711200e-03 -1.794763e-03 -1.882253e-03
## ASV0415     -2.412651e-04 -2.262782e-04 -2.095903e-04 -1.911047e-04
## ASV10103    -3.591005e-03 -3.737805e-03 -3.889711e-03 -4.046878e-03
## ASV1613      4.861900e-03  5.025502e-03  5.192592e-03  5.363101e-03
## ASV0135      8.755416e-04  9.563106e-04  1.042876e-03  1.135583e-03
## ASV0469     -6.093572e-03 -6.306897e-03 -6.525980e-03 -6.750899e-03
## ASV0471      4.453388e-03  4.632052e-03  4.817093e-03  5.008687e-03
## ASV0451     -1.694297e-03 -1.778649e-03 -1.866853e-03 -1.958998e-03
## ASV0747      2.232219e-03  2.336601e-03  2.445239e-03  2.558206e-03
## ASV1314     -3.461928e-03 -3.635555e-03 -3.817784e-03 -4.009045e-03
## ASV0425     -6.243466e-03 -6.432622e-03 -6.624802e-03 -6.819935e-03
## ASV0559     -3.729535e-03 -3.859342e-03 -3.993248e-03 -4.131393e-03
## ASV0148     -3.632459e-03 -3.729063e-03 -3.825844e-03 -3.922616e-03
## ASV0129     -1.118765e-03 -1.113614e-03 -1.105127e-03 -1.093044e-03
## ASV1072      1.646767e-03  1.685080e-03  1.722995e-03  1.760460e-03
## ASV2390      1.144192e-03  1.167865e-03  1.190928e-03  1.213261e-03
## ASV0548      5.248157e-03  5.461677e-03  5.682724e-03  5.911464e-03
## ASV0168     -6.909775e-03 -7.158898e-03 -7.415197e-03 -7.678789e-03
## ASV0066     -5.221520e-03 -5.408363e-03 -5.599997e-03 -5.796398e-03
## ASV0468     -2.107721e-03 -2.193574e-03 -2.282662e-03 -2.375143e-03
## ASV0172     -2.255141e-05  1.921742e-05  6.498531e-05  1.149891e-04
## ASV0236     -1.333059e-03 -1.328008e-03 -1.319412e-03 -1.307026e-03
## ASV0250      2.009019e-03  2.160599e-03  2.322049e-03  2.493893e-03
## ASV0338      3.963410e-04  4.355235e-04  4.770053e-04  5.208634e-04
## ASV0450     -1.872546e-05 -2.059097e-05 -2.280233e-05 -2.538476e-05
## ASV0377      6.063664e-03  6.295404e-03  6.534156e-03  6.780033e-03
## ASV1022      1.845314e-03  1.924862e-03  2.007676e-03  2.093907e-03
## ASV6174     -3.869158e-04 -4.026835e-04 -4.190777e-04 -4.361420e-04
## ASV0786      4.523454e-04  4.626591e-04  4.729210e-04  4.831389e-04
## ASV0053     -7.420415e-03 -7.709384e-03 -8.007640e-03 -8.315336e-03
## ASV0697     -1.534547e-03 -1.573288e-03 -1.612096e-03 -1.650896e-03
## ASV0785      5.482555e-03  5.696043e-03  5.916603e-03  6.144401e-03
## ASV1967     -2.993076e-03 -3.090204e-03 -3.189478e-03 -3.290932e-03
## ASV0385     -1.145854e-03 -1.172233e-03 -1.198552e-03 -1.224757e-03
## ASV0295      1.034617e-03  1.116342e-03  1.203570e-03  1.296617e-03
## ASV0072     -4.751115e-03 -4.890032e-03 -5.030318e-03 -5.171797e-03
## ASV0157     -1.407543e-03 -1.416502e-03 -1.422258e-03 -1.424467e-03
## ASV0501      3.385032e-03  3.542873e-03  3.707384e-03  3.878786e-03
## ASV10729    -4.724153e-03 -4.915197e-03 -5.112742e-03 -5.316963e-03
## ASV1470      1.809774e-03  1.866658e-03  1.924434e-03  1.983035e-03
## ASV0050     -1.382055e-02 -1.432208e-02 -1.483744e-02 -1.536677e-02
## ASV0411      7.560531e-05  9.539759e-05  1.167610e-04  1.397753e-04
## ASV0549      3.446248e-03  3.606893e-03  3.774622e-03  3.949677e-03
## ASV0184      1.792281e-03  1.868210e-03  1.947219e-03  2.029453e-03
## ASV0705      2.276046e-03  2.368439e-03  2.463742e-03  2.562003e-03
## ASV1715      5.410927e-03  5.629166e-03  5.855050e-03  6.088762e-03
## ASV0603      8.596826e-04  9.061197e-04  9.552305e-04  1.007197e-03
## ASV0826      1.375864e-03  1.415867e-03  1.456346e-03  1.497286e-03
## ASV0034     -5.796168e-03 -5.985375e-03 -6.178163e-03 -6.374429e-03
## ASV0838      1.194260e-03  1.228332e-03  1.262301e-03  1.296090e-03
## ASV0614     -3.442649e-03 -3.562833e-03 -3.685885e-03 -3.811818e-03
## ASV0014     -1.354664e-02 -1.404569e-02 -1.455913e-02 -1.508718e-02
## ASV0585     -9.594190e-04 -9.971271e-04 -1.035902e-03 -1.075712e-03
## ASV0016     -1.391438e-02 -1.442960e-02 -1.495987e-02 -1.550540e-02
## ASV5394     -3.816365e-03 -3.966526e-03 -4.121357e-03 -4.280936e-03
## ASV0666      2.954578e-03  3.061188e-03  3.170631e-03  3.282945e-03
## ASV2085      2.429942e-04  2.189762e-04  1.923520e-04  1.629694e-04
## ASV0003     -1.253424e-02 -1.299129e-02 -1.346129e-02 -1.394439e-02
## ASV0346      7.636829e-04  8.277302e-04  8.957013e-04  9.677657e-04
## ASV0267     -1.391917e-03 -1.419353e-03 -1.446197e-03 -1.472374e-03
## ASV0353      3.982641e-03  4.180942e-03  4.388458e-03  4.605550e-03
## ASV2419      3.445965e-03  3.569256e-03  3.695945e-03  3.826058e-03
## ASV0447      2.904303e-03  3.055019e-03  3.212714e-03  3.377637e-03
## ASV0654      6.198632e-03  6.447008e-03  6.703393e-03  6.967883e-03
## ASV0151      1.789676e-03  1.896694e-03  2.009832e-03  2.129405e-03
## ASV0065     -5.096270e-03 -5.280397e-03 -5.469361e-03 -5.663168e-03
## ASV0527      3.779881e-03  3.921638e-03  4.067583e-03  4.217765e-03
## ASV4055     -1.902344e-03 -1.997633e-03 -2.097797e-03 -2.203118e-03
## ASV0166     -3.746694e-03 -3.866078e-03 -3.987792e-03 -4.111807e-03
## ASV0417     -3.487221e-03 -3.613298e-03 -3.743027e-03 -3.876457e-03
## ASV0078     -2.362378e-03 -2.423349e-03 -2.483891e-03 -2.543801e-03
## ASV0322     -2.946606e-03 -3.030628e-03 -3.115293e-03 -3.200519e-03
## ASV0156     -4.330062e-03 -4.483307e-03 -4.640783e-03 -4.802548e-03
## ASV0648     -4.759433e-03 -4.960309e-03 -5.168685e-03 -5.384798e-03
## ASV0407      6.706220e-04  7.099541e-04  7.514734e-04  7.952615e-04
## ASV2030     -6.661795e-04 -6.893062e-04 -7.134793e-04 -7.387986e-04
## ASV0300      3.389979e-03  3.551520e-03  3.719955e-03  3.895504e-03
## ASV1150      2.310324e-05  3.807191e-05  5.446964e-05  7.235371e-05
## ASV0958      3.708590e-03  3.899340e-03  4.099827e-03  4.310532e-03
## ASV0216     -3.840352e-03 -3.970508e-03 -4.104381e-03 -4.242088e-03
## ASV0446      7.518478e-03  7.850184e-03  8.194799e-03  8.552688e-03
## ASV0367     -2.101018e-03 -2.180716e-03 -2.262975e-03 -2.347838e-03
## ASV0200     -4.140530e-03 -4.306493e-03 -4.478300e-03 -4.656090e-03
## ASV0334     -8.639695e-04 -8.575581e-04 -8.489110e-04 -8.379359e-04
## ASV1311      2.603554e-03  2.693872e-03  2.786313e-03  2.880878e-03
## ASV0458      3.010103e-03  3.126458e-03  3.246642e-03  3.370760e-03
## ASV1371      1.425549e-04  1.494961e-04  1.567140e-04  1.641959e-04
## ASV0418      3.863099e-03  4.019283e-03  4.181117e-03  4.348793e-03
## ASV0004      4.380238e-03  4.546035e-03  4.716871e-03  4.892806e-03
## ASV1943      2.976100e-03  3.083733e-03  3.194490e-03  3.308386e-03
## ASV1495     -1.577853e-03 -1.670280e-03 -1.767886e-03 -1.870900e-03
## ASV0901     -5.834076e-03 -6.091516e-03 -6.359557e-03 -6.638556e-03
## ASV0628      2.494624e-03  2.569160e-03  2.644330e-03  2.719989e-03
## ASV0400      9.952637e-04  1.023878e-03  1.052505e-03  1.081078e-03
## ASV0116     -4.811034e-03 -5.032441e-03 -5.263337e-03 -5.504040e-03
## ASV0788      3.316509e-03  3.447679e-03  3.583157e-03  3.723041e-03
## ASV0117      2.792937e-03  2.930228e-03  3.073952e-03  3.224383e-03
## ASV3137      5.011554e-04  5.187936e-04  5.369989e-04  5.557848e-04
## ASV0001      4.384436e-03  4.518269e-03  4.654212e-03  4.792189e-03
## ASV1651      3.016402e-03  3.116892e-03  3.219993e-03  3.325760e-03
## ASV1692      4.622771e-03  4.832672e-03  5.051334e-03  5.279061e-03
## ASV0660      1.348457e-03  1.364001e-03  1.377288e-03  1.388096e-03
## ASV0508      5.214842e-05  4.862430e-05  4.478245e-05  4.058611e-05
## ASV1660     -2.003730e-03 -2.094828e-03 -2.189478e-03 -2.287782e-03
## ASV0233      1.242816e-03  1.307858e-03  1.376301e-03  1.448323e-03
## ASV1343     -4.147640e-03 -4.321588e-03 -4.502138e-03 -4.689514e-03
## ASV0209      2.845620e-03  2.932387e-03  3.020711e-03  3.110571e-03
## ASV0193     -4.055180e-03 -4.193316e-03 -4.334899e-03 -4.479985e-03
## ASV0357      5.333720e-04  5.892400e-04  6.495560e-04  7.146136e-04
## ASV0198      1.121272e-03  1.171914e-03  1.224867e-03  1.280248e-03
## ASV0007      4.161167e-03  4.288409e-03  4.417673e-03  4.548890e-03
## ASV1772     -3.693330e-04 -3.731833e-04 -3.760204e-04 -3.776844e-04
## ASV0009      3.871754e-03  3.987913e-03  4.105764e-03  4.225235e-03
## ASV0006      9.468580e-04  9.483622e-04  9.478689e-04  9.452435e-04
## ASV0011     -5.946204e-03 -6.198971e-03 -6.461386e-03 -6.733726e-03
## ASV0015      3.692216e-03  3.830901e-03  3.973610e-03  4.120367e-03
## ASV0017      3.886190e-03  4.032300e-03  4.182739e-03  4.337548e-03
## ASV0235     -3.379638e-03 -3.518329e-03 -3.661929e-03 -3.810571e-03
## ASV0382      1.387663e-03  1.464005e-03  1.543467e-03  1.626069e-03
## ASV2357      5.091841e-03  5.304462e-03  5.525211e-03  5.754346e-03
## ASV0567     -3.309334e-03 -3.438416e-03 -3.572237e-03 -3.710994e-03
## ASV0165      3.786653e-03  3.933425e-03  4.084935e-03  4.241294e-03
## ASV0005      6.938081e-03  7.176598e-03  7.420555e-03  7.669902e-03
## ASV0384      3.663167e-04  4.138436e-04  4.655628e-04  5.217821e-04
## ASV0002      2.170752e-03  2.276931e-03  2.388068e-03  2.504339e-03
## ASV3017      3.886963e-03  4.017839e-03  4.151835e-03  4.288972e-03
## ASV0091      1.982970e-03  2.068900e-03  2.158032e-03  2.250449e-03
## ASV0186     -4.802484e-03 -4.992078e-03 -5.187598e-03 -5.389100e-03
## ASV0370      6.615352e-04  6.965000e-04  7.334295e-04  7.724374e-04
## ASV0018      7.367483e-03  7.627326e-03  7.893640e-03  8.166423e-03
## ASV1377      6.405980e-03  6.635158e-03  6.870590e-03  7.112351e-03
## ASV0019      7.402681e-03  7.665022e-03  7.934010e-03  8.209652e-03
## ASV0023     -3.927328e-04 -4.410116e-04 -4.926928e-04 -5.479204e-04
## ASV2194      3.050533e-03  3.188166e-03  3.331642e-03  3.481168e-03
## ASV1155      2.008652e-04  2.274116e-04  2.558992e-04  2.864131e-04
## ASV0510     -1.853201e-03 -1.889403e-03 -1.924947e-03 -1.959771e-03
## ASV2371     -2.232995e-03 -2.299906e-03 -2.367891e-03 -2.436924e-03
## ASV0024     -7.854078e-04 -8.493851e-04 -9.173115e-04 -9.893455e-04
## ASV2452      2.976816e-03  3.061975e-03  3.147968e-03  3.234721e-03
## ASV2332      1.011806e-03  1.076386e-03  1.144386e-03  1.215922e-03
## ASV2591      9.570133e-04  1.016398e-03  1.078720e-03  1.144060e-03
## ASV0521      5.991445e-03  6.258621e-03  6.536813e-03  6.826391e-03
## ASV5542      1.972870e-03  2.060349e-03  2.151207e-03  2.245534e-03
## ASV0336     -2.340660e-03 -2.430538e-03 -2.523417e-03 -2.619406e-03
## ASV10102     3.861002e-03  4.019282e-03  4.182963e-03  4.352146e-03
## ASV16823    -2.080411e-03 -2.141220e-03 -2.203048e-03 -2.265890e-03
## ASV3104      2.080387e-03  2.141192e-03  2.203015e-03  2.265851e-03
## ASV0781      1.214216e-03  1.256777e-03  1.300551e-03  1.345574e-03
## ASV10899     2.155616e-03  2.269462e-03  2.388871e-03  2.514059e-03
## ASV11222    -2.080355e-03 -2.141155e-03 -2.202972e-03 -2.265801e-03
## ASV11327    -2.080329e-03 -2.141125e-03 -2.202936e-03 -2.265760e-03
## ASV12458    -2.080303e-03 -2.141094e-03 -2.202901e-03 -2.265719e-03
## ASV1636     -1.628504e-03 -1.672781e-03 -1.717634e-03 -1.763064e-03
## ASV1890     -2.291700e-03 -2.370617e-03 -2.451942e-03 -2.535768e-03
## ASV2898      5.437942e-03  5.628275e-03  5.823556e-03  6.023846e-03
## ASV8328      5.279662e-04  5.823070e-04  6.404668e-04  7.026333e-04
## ASV0709     -4.511064e-03 -4.669586e-03 -4.832148e-03 -4.998776e-03
## ASV0856      1.152159e-03  1.209498e-03  1.269438e-03  1.332067e-03
## ASV0909     -8.494684e-04 -8.404836e-04 -8.288309e-04 -8.143531e-04
## ASV0937     -4.183575e-03 -4.365788e-03 -4.555640e-03 -4.753435e-03
## ASV11390    -2.080223e-03 -2.141001e-03 -2.202794e-03 -2.265596e-03
## ASV11966     1.983057e-03  2.077724e-03  2.176415e-03  2.279250e-03
## ASV12990     7.871678e-04  8.168003e-04  8.473163e-04  8.787279e-04
## ASV14797     2.392228e-03  2.468307e-03  2.546002e-03  2.625321e-03
## ASV14904    -2.080180e-03 -2.140951e-03 -2.202736e-03 -2.265530e-03
## ASV15304     1.394093e-03  1.467990e-03  1.545327e-03  1.626215e-03
## ASV16696    -2.080147e-03 -2.140913e-03 -2.202693e-03 -2.265480e-03
## ASV1690      2.103323e-03  2.201757e-03  2.303952e-03  2.409970e-03
## ASV2029      7.343791e-03  7.616576e-03  7.897535e-03  8.186810e-03
## ASV2834      4.308720e-03  4.483537e-03  4.664505e-03  4.851778e-03
## ASV4003      2.205945e-03  2.329462e-03  2.459580e-03  2.596611e-03
## ASV4064      3.213409e-03  3.346940e-03  3.485194e-03  3.628286e-03
## ASV4294      1.777054e-03  1.874651e-03  1.977311e-03  2.085254e-03
## ASV4609      9.186599e-05  1.018082e-04  1.124752e-04  1.239065e-04
## ASV6283     -2.080083e-03 -2.140839e-03 -2.202609e-03 -2.265386e-03
## ASV6491     -2.080062e-03 -2.140816e-03 -2.202582e-03 -2.265356e-03
## ASV7453      1.865321e-03  1.962516e-03  2.064237e-03  2.170631e-03
## ASV7959      9.529394e-04  1.013750e-03  1.077921e-03  1.145594e-03
## ASV8219      2.080029e-03  2.140778e-03  2.202540e-03  2.265309e-03
## ASV8547     -2.080012e-03 -2.140759e-03 -2.202520e-03 -2.265286e-03
## ASV9319      2.239059e-03  2.339612e-03  2.444466e-03  2.553796e-03
## ASV9382     -2.079994e-03 -2.140738e-03 -2.202496e-03 -2.265260e-03
## ASV11516    -2.079981e-03 -2.140723e-03 -2.202480e-03 -2.265243e-03
## ASV14377    -2.079970e-03 -2.140711e-03 -2.202467e-03 -2.265229e-03
## ASV1867      4.477484e-03  4.664303e-03  4.857961e-03  5.058649e-03
## ASV1895     -6.860834e-04 -7.077370e-04 -7.300963e-04 -7.532045e-04
## ASV3168      1.392064e-03  1.430244e-03  1.468587e-03  1.507041e-03
## ASV4449      2.952600e-03  3.054989e-03  3.160323e-03  3.268676e-03
## ASV6596      2.913836e-03  3.062275e-03  3.217933e-03  3.381115e-03
## ASV7492     -1.725087e-04 -1.523091e-04 -1.300127e-04 -1.055155e-04
## ASV9854     -9.642060e-04 -9.891546e-04 -1.014334e-03 -1.039732e-03
## ASV6296      2.079939e-03  2.140677e-03  2.202431e-03  2.265191e-03
## ASV4201      2.046402e-03  2.165644e-03  2.291267e-03  2.423553e-03
## ASV0552      7.596362e-03  7.915477e-03  8.246063e-03  8.588379e-03
## ASV3671     -9.143882e-06  4.351663e-06  1.872245e-05  3.397500e-05
## ASV3529      1.604741e-04  1.874110e-04  2.160563e-04  2.464526e-04
## ASV1060      2.088930e-03  2.188702e-03  2.293341e-03  2.403098e-03
## ASV0239     -2.872855e-03 -2.949042e-03 -3.025641e-03 -3.102558e-03
## ASV5711     -2.997074e-03 -3.097584e-03 -3.200630e-03 -3.306241e-03
## ASV4152     -4.416856e-03 -4.579402e-03 -4.746709e-03 -4.918840e-03
## ASV1461      3.264069e-03  3.358298e-03  3.453833e-03  3.550638e-03
## ASV2877      3.125950e-03  3.233120e-03  3.342685e-03  3.454624e-03
## ASV0012      3.217091e-03  3.366272e-03  3.521867e-03  3.684083e-03
## ASV9823      5.452152e-04  5.516822e-04  5.574697e-04  5.625312e-04
## ASV0008      3.398250e-03  3.553166e-03  3.714658e-03  3.882943e-03
## ASV7832     -2.626586e-03 -2.722367e-03 -2.821058e-03 -2.922715e-03
## ASV1915      5.148178e-04  5.398121e-04  5.655534e-04  5.920223e-04
## ASV0055      1.914093e-03  1.982634e-03  2.052798e-03  2.124548e-03
## ASV0032      4.230142e-03  4.373703e-03  4.520850e-03  4.671632e-03
## ASV2977     -3.695772e-03 -3.830274e-03 -3.968570e-03 -4.110694e-03
## ASV0466      3.280310e-03  3.381186e-03  3.483690e-03  3.587763e-03
## ASV3866      4.634836e-03  4.831447e-03  5.035827e-03  5.248268e-03
## ASV0040      6.479031e-03  6.761529e-03  7.055155e-03  7.360234e-03
## ASV0496     -1.137859e-03 -1.212069e-03 -1.290513e-03 -1.373378e-03
## ASV0052      6.448185e-03  6.679516e-03  6.916958e-03  7.160547e-03
## ASV3828     -3.963544e-03 -4.114693e-03 -4.271057e-03 -4.432806e-03
## ASV1930      2.574648e-03  2.667374e-03  2.762399e-03  2.859720e-03
## ASV2126      4.133858e-03  4.287042e-03  4.444677e-03  4.606830e-03
## ASV0793      3.479129e-03  3.645029e-03  3.818105e-03  3.998589e-03
## ASV0299     -1.094611e-03 -1.119425e-03 -1.144627e-03 -1.170279e-03
## ASV0208      4.882760e-03  5.108466e-03  5.344134e-03  5.590159e-03
## ASV0511     -1.107096e-03 -1.114101e-03 -1.119475e-03 -1.123152e-03
## ASV1123     -2.080568e-03 -2.135301e-03 -2.190376e-03 -2.245744e-03
## ASV0099     -1.179896e-03 -1.202608e-03 -1.223929e-03 -1.243660e-03
## ASV0752     -6.544008e-04 -6.888322e-04 -7.247973e-04 -7.623435e-04
## ASV0883      2.666843e-04  2.838562e-04  3.019304e-04  3.209389e-04
## ASV0683      4.224233e-03  4.411629e-03  4.606581e-03  4.809327e-03
## ASV4117     -4.013789e-03 -4.165956e-03 -4.323139e-03 -4.485463e-03
## ASV2172      1.656059e-03  1.723158e-03  1.792690e-03  1.864733e-03
## ASV0330     -3.017361e-03 -3.138011e-03 -3.262769e-03 -3.391738e-03
## ASV0728      3.237397e-03  3.377924e-03  3.523813e-03  3.675217e-03
## ASV0499      6.498354e-03  6.795255e-03  7.104926e-03  7.427833e-03
## ASV0120     -5.862342e-03 -6.079356e-03 -6.302358e-03 -6.531392e-03
## ASV1446     -1.476517e-04 -1.783772e-04 -2.119067e-04 -2.484352e-04
## ASV17171    -3.914940e-03 -4.067978e-03 -4.226428e-03 -4.390455e-03
## ASV0533      1.498294e-03  1.570721e-03  1.646484e-03  1.725723e-03
## ASV2495     -2.031040e-03 -2.129052e-03 -2.231684e-03 -2.339117e-03
## ASV5582      8.890416e-04  9.052456e-04  9.209651e-04  9.361488e-04
## ASV1488      1.565343e-03  1.633584e-03  1.704324e-03  1.777610e-03
## ASV0682      4.475524e-03  4.676723e-03  4.886221e-03  5.104300e-03
## ASV0068     -8.148992e-04 -8.642239e-04 -9.158631e-04 -9.698605e-04
## ASV1987     -2.862630e-03 -3.004487e-03 -3.153005e-03 -3.308457e-03
## ASV0035     -5.619951e-04 -6.402653e-04 -7.254188e-04 -8.179199e-04
## ASV7192     -2.131695e-03 -2.193477e-03 -2.255923e-03 -2.318963e-03
## ASV0873     -4.805214e-05 -6.163130e-05 -7.607103e-05 -9.138788e-05
## ASV4749     -8.306232e-04 -9.030057e-04 -9.803118e-04 -1.062794e-03
## ASV2174      1.918542e-03  1.974172e-03  2.030964e-03  2.088975e-03
## ASV1476     -2.468905e-03 -2.576829e-03 -2.689204e-03 -2.806176e-03
## ASV0740     -6.381541e-03 -6.663725e-03 -6.957315e-03 -7.262680e-03
## ASV0170      1.215287e-03  1.265545e-03  1.317704e-03  1.371830e-03
## ASV2466     -5.090612e-03 -5.299139e-03 -5.515576e-03 -5.740190e-03
## ASV1709      3.655438e-03  3.791019e-03  3.930613e-03  4.074273e-03
## ASV6170     -3.842956e-03 -4.002549e-03 -4.167935e-03 -4.339263e-03
## ASV3673      4.438215e-03  4.624058e-03  4.816753e-03  5.016484e-03
## ASV1745      3.407451e-04  3.539614e-04  3.675131e-04  3.813906e-04
##                                                                    
## (Intercept) -2.712601e-03 -2.951702e-03 -3.207913e-03 -3.482082e-03
## ASV1236      2.781797e-03  2.868550e-03  2.957068e-03  3.047353e-03
## ASV0421     -5.094956e-03 -5.256344e-03 -5.421061e-03 -5.589118e-03
## ASV0691     -3.777694e-03 -3.880422e-03 -3.984673e-03 -4.090453e-03
## ASV0899      2.858978e-04  3.004420e-04  3.151759e-04  3.300632e-04
## ASV1004      5.765358e-03  5.944191e-03  6.126227e-03  6.311422e-03
## ASV1041     -3.838840e-03 -3.952164e-03 -4.066951e-03 -4.183130e-03
## ASV1058      5.493713e-03  5.673692e-03  5.857847e-03  6.046217e-03
## ASV12542     1.347805e-03  1.382621e-03  1.417908e-03  1.453678e-03
## ASV1294      6.730844e-03  6.961599e-03  7.198142e-03  7.440529e-03
## ASV13113     3.394864e-03  3.552887e-03  3.717905e-03  3.890190e-03
## ASV1318      5.532982e-03  5.710416e-03  5.891551e-03  6.076384e-03
## ASV2269     -1.632099e-03 -1.682593e-03 -1.733953e-03 -1.786161e-03
## ASV2542      4.790429e-03  4.995015e-03  5.207442e-03  5.427941e-03
## ASV2660     -2.934962e-03 -3.020953e-03 -3.108345e-03 -3.197126e-03
## ASV2737     -3.722394e-04 -3.886522e-04 -4.054842e-04 -4.227223e-04
## ASV2840      3.692532e-03  3.789929e-03  3.888047e-03  3.986815e-03
## ASV3053      1.806150e-04  1.869083e-04  1.935310e-04  2.005095e-04
## ASV3077      1.281427e-03  1.323377e-03  1.366427e-03  1.410607e-03
## ASV3134      6.618092e-03  6.919820e-03  7.234590e-03  7.562898e-03
## ASV3140      2.548157e-03  2.648385e-03  2.751777e-03  2.858383e-03
## ASV3579      1.725827e-03  1.818765e-03  1.916178e-03  2.018214e-03
## ASV6119     -1.631369e-03 -1.681801e-03 -1.733101e-03 -1.785251e-03
## ASV7557     -1.631283e-03 -1.681711e-03 -1.733006e-03 -1.785154e-03
## ASV8422      7.827633e-04  8.061045e-04  8.300130e-04  8.545077e-04
## ASV1086     -4.037327e-04 -4.170052e-04 -4.307444e-04 -4.449755e-04
## ASV1310      3.291078e-03  3.397932e-03  3.506690e-03  3.617283e-03
## ASV15750    -6.534996e-04 -6.683669e-04 -6.830883e-04 -6.976321e-04
## ASV16905    -1.631123e-03 -1.681554e-03 -1.732857e-03 -1.785018e-03
## ASV2033      4.267504e-03  4.448231e-03  4.635459e-03  4.829332e-03
## ASV2089      1.131499e-03  1.166266e-03  1.201570e-03  1.237394e-03
## ASV2127      4.647724e-03  4.802599e-03  4.961081e-03  5.123183e-03
## ASV2725      4.636386e-03  4.769046e-03  4.903558e-03  5.039880e-03
## ASV2804     -1.631079e-03 -1.681520e-03 -1.732838e-03 -1.785019e-03
## ASV3075      3.779782e-03  3.930972e-03  4.087919e-03  4.250836e-03
## ASV3327      4.070024e-03  4.242402e-03  4.421213e-03  4.606631e-03
## ASV3342      4.081147e-03  4.242621e-03  4.409511e-03  4.581942e-03
## ASV3532     -3.726252e-03 -3.879365e-03 -4.038342e-03 -4.203399e-03
## ASV3600      4.587872e-03  4.768265e-03  4.954665e-03  5.147203e-03
## ASV4013      3.344902e-03  3.457230e-03  3.572041e-03  3.689315e-03
## ASV4136      3.064366e-03  3.162888e-03  3.263715e-03  3.366880e-03
## ASV4195      1.631090e-03  1.681553e-03  1.732897e-03  1.785112e-03
## ASV4407     -1.631104e-03 -1.681573e-03 -1.732926e-03 -1.785150e-03
## ASV4717     -8.634860e-05 -9.239269e-05 -9.856360e-05 -1.048458e-04
## ASV6794      1.494438e-03  1.540917e-03  1.588662e-03  1.637720e-03
## ASV8324     -1.631176e-03 -1.681667e-03 -1.733046e-03 -1.785301e-03
## ASV8981      9.055182e-06  2.886713e-05  5.046961e-05  7.394854e-05
## ASV9859      2.382359e-03  2.510336e-03  2.645061e-03  2.786855e-03
## ASV0936     -2.738376e-03 -2.832465e-03 -2.928945e-03 -3.027840e-03
## ASV12683    -4.181066e-04 -4.344966e-04 -4.512529e-04 -4.683643e-04
## ASV1293      3.752737e-03  3.871760e-03  3.993279e-03  4.117305e-03
## ASV13055    -2.322333e-04 -2.320710e-04 -2.313643e-04 -2.300780e-04
## ASV17063    -1.631382e-03 -1.681916e-03 -1.733344e-03 -1.785655e-03
## ASV2228      1.631423e-03  1.681965e-03  1.733401e-03  1.785720e-03
## ASV2769      3.398704e-05  4.609102e-05  5.892583e-05  7.248883e-05
## ASV2803      6.128038e-04  6.290184e-04  6.455368e-04  6.623717e-04
## ASV2896      2.745100e-03  2.870044e-03  3.000896e-03  3.137953e-03
## ASV3062      1.363384e-03  1.436981e-03  1.514122e-03  1.594923e-03
## ASV3107      3.091064e-03  3.216019e-03  3.345440e-03  3.479445e-03
## ASV3265      4.820283e-03  4.969517e-03  5.121518e-03  5.276260e-03
## ASV3666     -2.281512e-04 -2.409200e-04 -2.543904e-04 -2.685944e-04
## ASV4497      1.184236e-03  1.223035e-03  1.262724e-03  1.303312e-03
## ASV6914     -7.016744e-04 -7.280815e-04 -7.552651e-04 -7.832379e-04
## ASV0576     -5.147600e-03 -5.294815e-03 -5.444543e-03 -5.596798e-03
## ASV0673      2.146785e-03  2.232805e-03  2.321292e-03  2.412248e-03
## ASV0772      2.057193e-03  2.136664e-03  2.218841e-03  2.303799e-03
## ASV0862     -9.621031e-04 -9.764811e-04 -9.902464e-04 -1.003367e-03
## ASV0898      2.210902e-03  2.307487e-03  2.407536e-03  2.511112e-03
## ASV0910      4.557870e-03  4.757942e-03  4.965750e-03  5.181512e-03
## ASV0964     -1.897041e-03 -1.949210e-03 -2.001929e-03 -2.055174e-03
## ASV10059     2.310121e-03  2.419773e-03  2.534312e-03  2.653920e-03
## ASV10263    -1.631961e-03 -1.682585e-03 -1.734114e-03 -1.786535e-03
## ASV1088      2.631224e-03  2.758430e-03  2.891532e-03  3.030766e-03
## ASV1101      2.991421e-03  3.084509e-03  3.178768e-03  3.274094e-03
## ASV1183      2.163972e-03  2.245733e-03  2.330022e-03  2.416892e-03
## ASV11956     4.783480e-04  4.887081e-04  4.992092e-04  5.098663e-04
## ASV12774    -4.111106e-04 -4.298091e-04 -4.492337e-04 -4.694036e-04
## ASV1321      1.619698e-03  1.706445e-03  1.797255e-03  1.892253e-03
## ASV13793    -1.632156e-03 -1.682802e-03 -1.734354e-03 -1.786800e-03
## ASV14482    -2.700635e-04 -2.800492e-04 -2.901548e-04 -3.003628e-04
## ASV15483     1.507683e-03  1.569932e-03  1.634399e-03  1.701142e-03
## ASV2062      8.146041e-03  8.439841e-03  8.741787e-03  9.051978e-03
## ASV2132      4.306123e-03  4.484020e-03  4.668280e-03  4.859059e-03
## ASV2413      4.856659e-03  5.021773e-03  5.191158e-03  5.364880e-03
## ASV2490      2.818879e-03  2.900088e-03  2.982486e-03  3.066048e-03
## ASV2594      2.164914e-03  2.260711e-03  2.360837e-03  2.465489e-03
## ASV2822     -1.632347e-03 -1.683016e-03 -1.734593e-03 -1.787066e-03
## ASV2863      2.807575e-03  2.897319e-03  2.989079e-03  3.082877e-03
## ASV2910      3.593774e-03  3.705968e-03  3.820506e-03  3.937408e-03
## ASV2980      1.253491e-03  1.288378e-03  1.323597e-03  1.359122e-03
## ASV3307      1.632490e-03  1.683175e-03  1.734768e-03  1.787260e-03
## ASV3474      3.777480e-03  3.943787e-03  4.116351e-03  4.295310e-03
## ASV3502      6.221266e-03  6.457335e-03  6.701082e-03  6.952716e-03
## ASV4236      2.491018e-03  2.563129e-03  2.636366e-03  2.710719e-03
## ASV4842     -9.110748e-04 -9.381516e-04 -9.655225e-04 -9.931627e-04
## ASV4894     -1.632617e-03 -1.683317e-03 -1.734928e-03 -1.787439e-03
## ASV5290      2.276930e-03  2.356436e-03  2.437785e-03  2.520966e-03
## ASV5501      5.090014e-04  5.334595e-04  5.591807e-04  5.862307e-04
## ASV5795      1.865151e-03  1.943946e-03  2.025562e-03  2.110059e-03
## ASV5987     -1.632741e-03 -1.683457e-03 -1.735086e-03 -1.787617e-03
## ASV6267     -1.632782e-03 -1.683503e-03 -1.735137e-03 -1.787676e-03
## ASV6862      2.789035e-03  2.869851e-03  2.952192e-03  3.036079e-03
## ASV7145      5.269349e-04  5.464686e-04  5.668542e-04  5.881371e-04
## ASV7673     -1.632875e-03 -1.683610e-03 -1.735261e-03 -1.787818e-03
## ASV7789      1.427796e-03  1.509160e-03  1.594780e-03  1.684829e-03
## ASV7809      1.724544e-04  1.923267e-04  2.134808e-04  2.359567e-04
## ASV8002     -1.633000e-03 -1.683753e-03 -1.735425e-03 -1.788008e-03
## ASV8205      1.205856e-03  1.257059e-03  1.310311e-03  1.365678e-03
## ASV9155     -1.172273e-03 -1.206187e-03 -1.240536e-03 -1.275301e-03
## ASV9221      2.980601e-04  3.287403e-04  3.615853e-04  3.966984e-04
## ASV9311     -1.633202e-03 -1.683987e-03 -1.735698e-03 -1.788325e-03
## ASV9557     -1.633262e-03 -1.684057e-03 -1.735779e-03 -1.788420e-03
## ASV9936     -1.633324e-03 -1.684130e-03 -1.735864e-03 -1.788520e-03
## ASV1445      4.855916e-03  5.055528e-03  5.262440e-03  5.476863e-03
## ASV4232      4.761080e-03  4.985645e-03  5.220584e-03  5.466338e-03
## ASV6479      7.607838e-04  8.180916e-04  8.789867e-04  9.436351e-04
## ASV0142     -7.914981e-03 -8.157369e-03 -8.404361e-03 -8.655944e-03
## ASV0378     -2.134780e-03 -2.177523e-03 -2.219349e-03 -2.260142e-03
## ASV1122      6.358199e-03  6.613133e-03  6.876665e-03  7.148976e-03
## ASV0123     -7.710320e-03 -7.944427e-03 -8.182819e-03 -8.425475e-03
## ASV2064      5.710368e-04  5.814056e-04  5.916797e-04  6.018632e-04
## ASV4459     -8.408263e-04 -8.660125e-04 -8.917177e-04 -9.179565e-04
## ASV0448      2.675678e-03  2.810061e-03  2.950502e-03  3.097203e-03
## ASV0397      4.459575e-03  4.628739e-03  4.803073e-03  4.982667e-03
## ASV0485      5.932566e-03  6.154078e-03  6.382640e-03  6.618430e-03
## ASV1566      5.164935e-03  5.358250e-03  5.557311e-03  5.762208e-03
## ASV1365      3.413041e-03  3.541357e-03  3.673291e-03  3.808860e-03
## ASV1065      6.998936e-03  7.269071e-03  7.547907e-03  7.835625e-03
## ASV0722     -5.771408e-05 -6.033411e-05 -6.330765e-05 -6.667906e-05
## ASV12660    -2.535495e-03 -2.610902e-03 -2.687613e-03 -2.765619e-03
## ASV0223      1.809203e-05  2.669828e-05  3.627764e-05  4.690761e-05
## ASV0229      3.493660e-03  3.642623e-03  3.797353e-03  3.958034e-03
## ASV0877     -7.068627e-04 -7.218399e-04 -7.369355e-04 -7.521692e-04
## ASV0983      5.700740e-03  5.897208e-03  6.098716e-03  6.305317e-03
## ASV0626     -9.735464e-04 -9.802598e-04 -9.859863e-04 -9.907043e-04
## ASV4146     -2.971325e-04 -3.107238e-04 -3.253105e-04 -3.409937e-04
## ASV4175     -3.824810e-03 -3.966110e-03 -4.111444e-03 -4.260861e-03
## ASV2082     -9.512266e-04 -1.014776e-03 -1.082141e-03 -1.153495e-03
## ASV2272      3.175472e-03  3.310797e-03  3.451240e-03  3.596938e-03
## ASV2245     -3.489820e-03 -3.625362e-03 -3.765326e-03 -3.909812e-03
## ASV0590     -2.979460e-03 -3.123831e-03 -3.274480e-03 -3.431608e-03
## ASV0217     -8.361274e-04 -7.968757e-04 -7.527776e-04 -7.036165e-04
## ASV0416      1.987568e-03  2.026256e-03  2.064124e-03  2.101063e-03
## ASV1056      4.606557e-03  4.805118e-03  5.010753e-03  5.223590e-03
## ASV7777     -3.425841e-03 -3.561361e-03 -3.701759e-03 -3.847207e-03
## ASV0455      8.641330e-04  8.977710e-04  9.320951e-04  9.670627e-04
## ASV0604      1.461919e-03  1.539034e-03  1.619611e-03  1.703756e-03
## ASV6100     -3.249228e-03 -3.381382e-03 -3.518539e-03 -3.660887e-03
## ASV11359    -3.286128e-03 -3.402657e-03 -3.522180e-03 -3.644712e-03
## ASV6604      2.860044e-03  2.984091e-03  3.112993e-03  3.246894e-03
## ASV5004     -1.954516e-03 -2.027641e-03 -2.103188e-03 -2.181236e-03
## ASV1483     -1.860262e-03 -1.930659e-03 -2.003285e-03 -2.078189e-03
## ASV9773     -4.073843e-03 -4.234823e-03 -4.401473e-03 -4.573969e-03
## ASV4059      8.927885e-04  9.442641e-04  9.983007e-04  1.054979e-03
## ASV1193      6.375778e-03  6.614841e-03  6.861117e-03  7.114723e-03
## ASV4610      1.865003e-04  2.114161e-04  2.375757e-04  2.649673e-04
## ASV0742     -1.162515e-03 -1.170520e-03 -1.177218e-03 -1.182569e-03
## ASV1502     -4.479883e-04 -4.771944e-04 -5.079003e-04 -5.401508e-04
## ASV0195     -1.182373e-03 -1.240980e-03 -1.302133e-03 -1.365918e-03
## ASV1213      1.359879e-03  1.388212e-03  1.416067e-03  1.443367e-03
## ASV1648     -2.987229e-03 -3.106475e-03 -3.230191e-03 -3.358549e-03
## ASV6984     -2.377935e-03 -2.478552e-03 -2.583323e-03 -2.692429e-03
## ASV0396      7.609414e-05  1.291296e-04  1.860519e-04  2.469691e-04
## ASV4297      2.626503e-03  2.706196e-03  2.787408e-03  2.870138e-03
## ASV2622      6.436475e-03  6.648725e-03  6.866114e-03  7.088711e-03
## ASV3512      2.103960e-03  2.222267e-03  2.346992e-03  2.478442e-03
## ASV2411      3.173230e-03  3.312497e-03  3.457028e-03  3.606937e-03
## ASV2291     -1.204479e-03 -1.269923e-03 -1.338557e-03 -1.410490e-03
## ASV0807      4.232300e-03  4.428258e-03  4.631968e-03  4.843623e-03
## ASV1292      1.520808e-03  1.576012e-03  1.633088e-03  1.692110e-03
## ASV1035      5.498742e-04  5.672610e-04  5.852862e-04  6.039906e-04
## ASV0070     -5.317929e-04 -5.059024e-04 -4.762874e-04 -4.427181e-04
## ASV0255      5.822892e-04  5.916752e-04  5.999173e-04  6.068462e-04
## ASV0057     -5.588432e-03 -5.725315e-03 -5.861929e-03 -5.998035e-03
## ASV0077     -1.024597e-04 -7.306123e-05 -4.108017e-05 -6.431221e-06
## ASV0625      6.250306e-03  6.438302e-03  6.629356e-03  6.823396e-03
## ASV2464      2.847073e-03  2.929917e-03  3.014151e-03  3.099767e-03
## ASV1315      7.956329e-03  8.299615e-03  8.655878e-03  9.025449e-03
## ASV2673      6.165114e-03  6.449210e-03  6.745655e-03  7.054914e-03
## ASV2161      2.625158e-03  2.748739e-03  2.877806e-03  3.012566e-03
## ASV0337     -2.951863e-03 -3.052649e-03 -3.155841e-03 -3.261450e-03
## ASV7680     -3.975527e-03 -4.133159e-03 -4.296202e-03 -4.464794e-03
## ASV0611      9.493493e-03  9.904743e-03  1.033246e-02  1.077719e-02
## ASV3118     -3.077182e-03 -3.202528e-03 -3.332262e-03 -3.466491e-03
## ASV1284      3.273719e-03  3.408153e-03  3.547284e-03  3.691206e-03
## ASV0889      2.147106e-03  2.229036e-03  2.313877e-03  2.401737e-03
## ASV4649     -2.361212e-03 -2.450978e-03 -2.543599e-03 -2.639139e-03
## ASV1108     -3.875325e-03 -4.053997e-03 -4.240252e-03 -4.434346e-03
## ASV0738      1.440553e-03  1.561419e-03  1.690148e-03  1.827123e-03
## ASV0473      5.716812e-04  5.984436e-04  6.263994e-04  6.555927e-04
## ASV0598     -2.367114e-03 -2.423477e-03 -2.479771e-03 -2.535914e-03
## ASV0429      4.966328e-03  5.135474e-03  5.308657e-03  5.485892e-03
## ASV1549      6.943873e-03  7.261322e-03  7.591936e-03  7.936118e-03
## ASV1203      3.943676e-03  4.085000e-03  4.230062e-03  4.378882e-03
## ASV4532      6.063514e-05  6.474490e-05  6.951884e-05  7.503900e-05
## ASV0274     -2.994753e-03 -3.074256e-03 -3.154643e-03 -3.235901e-03
## ASV0163     -4.144789e-03 -4.247879e-03 -4.351498e-03 -4.455575e-03
## ASV1298      1.791839e-03  1.846457e-03  1.902600e-03  1.960351e-03
## ASV9424     -5.540372e-03 -5.771404e-03 -6.011210e-03 -6.260072e-03
## ASV0412      7.318405e-03  7.581727e-03  7.852375e-03  8.130438e-03
## ASV0284      2.627856e-03  2.699722e-03  2.772148e-03  2.845047e-03
## ASV0620     -3.280129e-03 -3.425509e-03 -3.576504e-03 -3.733262e-03
## ASV0153     -6.228320e-03 -6.489423e-03 -6.759677e-03 -7.039247e-03
## ASV0498      1.816281e-03  1.916798e-03  2.021445e-03  2.130260e-03
## ASV0097      4.832337e-03  5.053331e-03  5.283707e-03  5.523786e-03
## ASV0104     -1.732008e-02 -1.795561e-02 -1.860943e-02 -1.928178e-02
## ASV1282      3.263263e-03  3.387549e-03  3.515285e-03  3.646466e-03
## ASV3883     -2.160271e-03 -2.249752e-03 -2.342044e-03 -2.437152e-03
## ASV0801      2.473109e-03  2.589669e-03  2.711327e-03  2.838275e-03
## ASV1611     -7.512493e-03 -7.820966e-03 -8.140543e-03 -8.471518e-03
## ASV0227     -3.479114e-03 -3.643595e-03 -3.815114e-03 -3.993911e-03
## ASV0833      3.636421e-03  3.802265e-03  3.974589e-03  4.153550e-03
## ASV0718      6.569039e-03  6.822003e-03  7.082809e-03  7.351572e-03
## ASV1139      1.158442e-03  1.159412e-03  1.157783e-03  1.153373e-03
## ASV0766     -1.435114e-03 -1.479977e-03 -1.525838e-03 -1.572717e-03
## ASV2091      6.870053e-03  7.076582e-03  7.286733e-03  7.500481e-03
## ASV1238      3.978787e-04  4.425295e-04  4.899997e-04  5.403719e-04
## ASV9193     -1.571720e-03 -1.655523e-03 -1.743072e-03 -1.834455e-03
## ASV0290     -1.118125e-03 -1.164962e-03 -1.212740e-03 -1.261373e-03
## ASV0231      6.563450e-03  6.803937e-03  7.051258e-03  7.305490e-03
## ASV0185      4.328071e-03  4.607637e-03  4.903385e-03  5.216059e-03
## ASV2330      1.635055e-03  1.687890e-03  1.742035e-03  1.797527e-03
## ASV3119     -3.495510e-03 -3.673386e-03 -3.859636e-03 -4.054578e-03
## ASV2368     -3.895567e-03 -4.077790e-03 -4.268319e-03 -4.467502e-03
## ASV0122     -1.833095e-03 -1.885072e-03 -1.937916e-03 -1.991643e-03
## ASV1044      5.661000e-03  5.925431e-03  6.201135e-03  6.488489e-03
## ASV0160     -4.077365e-03 -4.170667e-03 -4.263793e-03 -4.356652e-03
## ASV0326      3.925053e-03  4.071131e-03  4.221259e-03  4.375456e-03
## ASV1388      6.705925e-03  6.957301e-03  7.216468e-03  7.483588e-03
## ASV0792      6.847272e-03  7.072537e-03  7.302522e-03  7.537186e-03
## ASV0036     -5.388828e-03 -5.603995e-03 -5.825820e-03 -6.054346e-03
## ASV2125      7.748041e-03  8.030202e-03  8.320097e-03  8.617780e-03
## ASV1075      1.935235e-03  2.023981e-03  2.116460e-03  2.212797e-03
## ASV0390      2.639292e-03  2.786348e-03  2.941397e-03  3.104829e-03
## ASV3790     -6.874368e-03 -7.151162e-03 -7.437565e-03 -7.733815e-03
## ASV1535     -9.893939e-04 -1.043856e-03 -1.100977e-03 -1.160840e-03
## ASV0263      1.391420e-03  1.446887e-03  1.504308e-03  1.563741e-03
## ASV0675      1.255079e-02  1.309861e-02  1.366782e-02  1.425904e-02
## ASV3348      1.527615e-03  1.605575e-03  1.687298e-03  1.772937e-03
## ASV0058     -9.403772e-03 -9.730462e-03 -1.006501e-02 -1.040739e-02
## ASV4142      2.237181e-03  2.311099e-03  2.386758e-03  2.464181e-03
## ASV0059     -7.953418e-03 -8.222724e-03 -8.497956e-03 -8.779060e-03
## ASV0013     -1.764149e-02 -1.829329e-02 -1.896429e-02 -1.965482e-02
## ASV0033     -6.015849e-03 -6.263575e-03 -6.519674e-03 -6.784277e-03
## ASV4354     -2.040416e-03 -2.112871e-03 -2.187554e-03 -2.264522e-03
## ASV0022     -6.233426e-03 -6.484667e-03 -6.743917e-03 -7.011251e-03
## ASV0134     -1.973848e-03 -2.069737e-03 -2.170116e-03 -2.275192e-03
## ASV0415     -1.707442e-04 -1.484334e-04 -1.240974e-04 -9.766189e-05
## ASV10103    -4.209424e-03 -4.377464e-03 -4.551108e-03 -4.730466e-03
## ASV1613      5.536973e-03  5.714142e-03  5.894536e-03  6.078075e-03
## ASV0135      1.234762e-03  1.340755e-03  1.453916e-03  1.574607e-03
## ASV0469     -6.981745e-03 -7.218612e-03 -7.461594e-03 -7.710790e-03
## ASV0471      5.207041e-03  5.412366e-03  5.624883e-03  5.844820e-03
## ASV0451     -2.055209e-03 -2.155608e-03 -2.260318e-03 -2.369460e-03
## ASV0747      2.675602e-03  2.797518e-03  2.924045e-03  3.055266e-03
## ASV1314     -4.209755e-03 -4.420343e-03 -4.641256e-03 -4.872955e-03
## ASV0425     -7.017948e-03 -7.218770e-03 -7.422329e-03 -7.628552e-03
## ASV0559     -4.273949e-03 -4.421101e-03 -4.573046e-03 -4.729993e-03
## ASV0148     -4.019200e-03 -4.115405e-03 -4.211032e-03 -4.305874e-03
## ASV0129     -1.077112e-03 -1.057068e-03 -1.032646e-03 -1.003573e-03
## ASV1072      1.797394e-03  1.833713e-03  1.869332e-03  1.904171e-03
## ASV2390      1.234770e-03  1.255358e-03  1.274929e-03  1.293380e-03
## ASV0548      6.148086e-03  6.392778e-03  6.645726e-03  6.907120e-03
## ASV0168     -7.949813e-03 -8.228411e-03 -8.514729e-03 -8.808913e-03
## ASV0066     -5.997556e-03 -6.203454e-03 -6.414064e-03 -6.629346e-03
## ASV0468     -2.471151e-03 -2.570824e-03 -2.674309e-03 -2.781761e-03
## ASV0172      1.694559e-04  2.286168e-04  2.927069e-04  3.619654e-04
## ASV0236     -1.290617e-03 -1.269952e-03 -1.244796e-03 -1.214913e-03
## ASV0250      2.676654e-03  2.870872e-03  3.077100e-03  3.295908e-03
## ASV0338      5.671597e-04  6.159525e-04  6.672970e-04  7.212453e-04
## ASV0450     -2.839094e-05 -3.187975e-05 -3.591577e-05 -4.056988e-05
## ASV0377      7.033114e-03  7.293474e-03  7.561176e-03  7.836274e-03
## ASV1022      2.183691e-03  2.277167e-03  2.374477e-03  2.475772e-03
## ASV6174     -4.538971e-04 -4.723618e-04 -4.915530e-04 -5.114854e-04
## ASV0786      4.933016e-04  5.033977e-04  5.134165e-04  5.233476e-04
## ASV0053     -8.632641e-03 -8.959721e-03 -9.296738e-03 -9.643847e-03
## ASV0697     -1.689633e-03 -1.728253e-03 -1.766703e-03 -1.804927e-03
## ASV0785      6.379621e-03  6.622453e-03  6.873091e-03  7.131736e-03
## ASV1967     -3.394576e-03 -3.500418e-03 -3.608467e-03 -3.718729e-03
## ASV0385     -1.250823e-03 -1.276725e-03 -1.302443e-03 -1.327957e-03
## ASV0295      1.395786e-03  1.501387e-03  1.613740e-03  1.733171e-03
## ASV0072     -5.314294e-03 -5.457629e-03 -5.601609e-03 -5.746033e-03
## ASV0157     -1.422784e-03 -1.416847e-03 -1.406274e-03 -1.390665e-03
## ASV0501      4.057288e-03  4.243092e-03  4.436403e-03  4.637422e-03
## ASV10729    -5.527998e-03 -5.745983e-03 -5.971050e-03 -6.203327e-03
## ASV1470      2.042408e-03  2.102497e-03  2.163236e-03  2.224559e-03
## ASV0050     -1.591021e-02 -1.646787e-02 -1.703987e-02 -1.762632e-02
## ASV0411      1.644966e-04  1.909761e-04  2.192598e-04  2.493874e-04
## ASV0549      4.132329e-03  4.322853e-03  4.521530e-03  4.728648e-03
## ASV0184      2.115034e-03  2.204092e-03  2.296756e-03  2.393161e-03
## ASV0705      2.663243e-03  2.767479e-03  2.874721e-03  2.984972e-03
## ASV1715      6.330498e-03  6.580453e-03  6.838826e-03  7.105815e-03
## ASV0603      1.062187e-03  1.120379e-03  1.181956e-03  1.247114e-03
## ASV0826      1.538656e-03  1.580427e-03  1.622565e-03  1.665036e-03
## ASV0034     -6.574077e-03 -6.777003e-03 -6.983095e-03 -7.192230e-03
## ASV0838      1.329581e-03  1.362647e-03  1.395150e-03  1.426943e-03
## ASV0614     -3.940617e-03 -4.072261e-03 -4.206723e-03 -4.343969e-03
## ASV0014     -1.563002e-02 -1.618786e-02 -1.676087e-02 -1.734923e-02
## ASV0585     -1.116540e-03 -1.158365e-03 -1.201159e-03 -1.244892e-03
## ASV0016     -1.606643e-02 -1.664316e-02 -1.723581e-02 -1.784457e-02
## ASV5394     -4.445305e-03 -4.614496e-03 -4.788530e-03 -4.967415e-03
## ASV0666      3.398151e-03  3.516264e-03  3.637300e-03  3.761271e-03
## ASV2085      1.306936e-04  9.538907e-05  5.691838e-05  1.514266e-05
## ASV0003     -1.444078e-02 -1.495063e-02 -1.547409e-02 -1.601134e-02
## ASV0346      1.044074e-03  1.124776e-03  1.210021e-03  1.299955e-03
## ASV0267     -1.497829e-03 -1.522513e-03 -1.546380e-03 -1.569389e-03
## ASV0353      4.832572e-03  5.069878e-03  5.317829e-03  5.576790e-03
## ASV2419      3.959631e-03  4.096696e-03  4.237279e-03  4.381406e-03
## ASV0447      3.550027e-03  3.730122e-03  3.918164e-03  4.114394e-03
## ASV0654      7.240586e-03  7.521599e-03  7.811010e-03  8.108902e-03
## ASV0151      2.255719e-03  2.389088e-03  2.529836e-03  2.678293e-03
## ASV0065     -5.861827e-03 -6.065340e-03 -6.273704e-03 -6.486911e-03
## ASV0527      4.372238e-03  4.531050e-03  4.694246e-03  4.861869e-03
## ASV4055     -2.313868e-03 -2.430332e-03 -2.552808e-03 -2.681611e-03
## ASV0166     -4.238102e-03 -4.366654e-03 -4.497438e-03 -4.630429e-03
## ASV0417     -4.013657e-03 -4.154694e-03 -4.299638e-03 -4.448561e-03
## ASV0078     -2.602881e-03 -2.660917e-03 -2.717684e-03 -2.772944e-03
## ASV0322     -3.286200e-03 -3.372228e-03 -3.458489e-03 -3.544869e-03
## ASV0156     -4.968676e-03 -5.139240e-03 -5.314320e-03 -5.493993e-03
## ASV0648     -5.608862e-03 -5.841092e-03 -6.081705e-03 -6.330917e-03
## ASV0407      8.414214e-04  8.900590e-04  9.412832e-04  9.952057e-04
## ASV2030     -7.653544e-04 -7.932437e-04 -8.225706e-04 -8.534460e-04
## ASV0300      4.078373e-03  4.268763e-03  4.466872e-03  4.672897e-03
## ASV1150      9.180109e-05  1.128895e-04  1.356964e-04  1.602986e-04
## ASV0958      4.531935e-03  4.764535e-03  5.008848e-03  5.265407e-03
## ASV0216     -4.383765e-03 -4.529557e-03 -4.679624e-03 -4.834132e-03
## ASV0446      8.924202e-03  9.309688e-03  9.709490e-03  1.012395e-02
## ASV0367     -2.435369e-03 -2.525631e-03 -2.618691e-03 -2.714613e-03
## ASV0200     -4.840024e-03 -5.030260e-03 -5.226963e-03 -5.430294e-03
## ASV0334     -8.245344e-04 -8.086111e-04 -7.900748e-04 -7.688385e-04
## ASV1311      2.977554e-03  3.076324e-03  3.177166e-03  3.280053e-03
## ASV0458      3.498903e-03  3.631161e-03  3.767625e-03  3.908385e-03
## ASV1371      1.719413e-04  1.799492e-04  1.882169e-04  1.967409e-04
## ASV0418      4.522488e-03  4.702385e-03  4.888669e-03  5.081531e-03
## ASV0004      5.073913e-03  5.260260e-03  5.451914e-03  5.648935e-03
## ASV1943      3.425464e-03  3.545768e-03  3.669339e-03  3.796216e-03
## ASV1495     -1.979574e-03 -2.094170e-03 -2.214955e-03 -2.342204e-03
## ASV0901     -6.928893e-03 -7.230962e-03 -7.545162e-03 -7.871902e-03
## ASV0628      2.795996e-03  2.872198e-03  2.948430e-03  3.024513e-03
## ASV0400      1.109506e-03  1.137690e-03  1.165520e-03  1.192877e-03
## ASV0116     -5.754888e-03 -6.016223e-03 -6.288389e-03 -6.571736e-03
## ASV0788      3.867414e-03  4.016357e-03  4.169949e-03  4.328267e-03
## ASV0117      3.381785e-03  3.546430e-03  3.718594e-03  3.898558e-03
## ASV3137      5.751810e-04  5.952214e-04  6.159440e-04  6.373911e-04
## ASV0001      4.932136e-03  5.073984e-03  5.217663e-03  5.363102e-03
## ASV1651      3.434266e-03  3.545588e-03  3.659811e-03  3.777027e-03
## ASV1692      5.516152e-03  5.762913e-03  6.019653e-03  6.286687e-03
## ASV0660      1.396178e-03  1.401277e-03  1.403122e-03  1.401432e-03
## ASV0508      3.601756e-05  3.105801e-05  2.568648e-05  1.987976e-05
## ASV1660     -2.389822e-03 -2.495677e-03 -2.605422e-03 -2.719129e-03
## ASV0233      1.524095e-03  1.603800e-03  1.687624e-03  1.775761e-03
## ASV1343     -4.883932e-03 -5.085613e-03 -5.294782e-03 -5.511670e-03
## ASV0209      3.201955e-03  3.294851e-03  3.389244e-03  3.485123e-03
## ASV0193     -4.628619e-03 -4.780844e-03 -4.936706e-03 -5.096251e-03
## ASV0357      7.847064e-04  8.601402e-04  9.412334e-04  1.028317e-03
## ASV0198      1.338174e-03  1.398763e-03  1.462142e-03  1.528439e-03
## ASV0007      4.681997e-03  4.816932e-03  4.953630e-03  5.092023e-03
## ASV1772     -3.780147e-04 -3.768368e-04 -3.739606e-04 -3.691797e-04
## ASV0009      4.346264e-03  4.468784e-03  4.592729e-03  4.718033e-03
## ASV0006      9.403594e-04  9.330907e-04  9.233125e-04  9.109016e-04
## ASV0011     -7.016278e-03 -7.309336e-03 -7.613193e-03 -7.928144e-03
## ASV0015      4.271202e-03  4.426140e-03  4.585200e-03  4.748395e-03
## ASV0017      4.496776e-03  4.660466e-03  4.828658e-03  5.001383e-03
## ASV0235     -3.964387e-03 -4.123509e-03 -4.288072e-03 -4.458213e-03
## ASV0382      1.711808e-03  1.800670e-03  1.892626e-03  1.987630e-03
## ASV2357      5.992142e-03  6.238880e-03  6.494843e-03  6.760324e-03
## ASV0567     -3.854882e-03 -4.004102e-03 -4.158865e-03 -4.319390e-03
## ASV0165      4.402606e-03  4.568975e-03  4.740504e-03  4.917300e-03
## ASV0005      7.924593e-03  8.184568e-03  8.449758e-03  8.720085e-03
## ASV0384      5.828136e-04  6.489857e-04  7.206442e-04  7.981522e-04
## ASV0002      2.625936e-03  2.753053e-03  2.885885e-03  3.024628e-03
## ASV3017      4.429273e-03  4.572759e-03  4.719454e-03  4.869378e-03
## ASV0091      2.346214e-03  2.445391e-03  2.548037e-03  2.654203e-03
## ASV0186     -5.596639e-03 -5.810259e-03 -6.029994e-03 -6.255867e-03
## ASV0370      8.136463e-04  8.571852e-04  9.031897e-04  9.518021e-04
## ASV0018      8.445674e-03  8.731383e-03  9.023531e-03  9.322091e-03
## ASV1377      7.360513e-03  7.615149e-03  7.876328e-03  8.144118e-03
## ASV0019      8.491961e-03  8.780938e-03  9.076578e-03  9.378869e-03
## ASV0023     -6.068296e-04 -6.695533e-04 -7.362211e-04 -8.069588e-04
## ASV2194      3.636957e-03  3.799227e-03  3.968200e-03  4.144100e-03
## ASV1155      3.190347e-04  3.538462e-04  3.909290e-04  4.303643e-04
## ASV0510     -1.993812e-03 -2.027011e-03 -2.059313e-03 -2.090664e-03
## ASV2371     -2.506972e-03 -2.578001e-03 -2.649975e-03 -2.722852e-03
## ASV0024     -1.065638e-03 -1.146336e-03 -1.231586e-03 -1.321529e-03
## ASV2452      3.322160e-03  3.410211e-03  3.498798e-03  3.587847e-03
## ASV2332      1.291117e-03  1.370092e-03  1.452968e-03  1.539865e-03
## ASV2591      1.212502e-03  1.284127e-03  1.359014e-03  1.437240e-03
## ASV0521      7.127740e-03  7.441250e-03  7.767322e-03  8.106361e-03
## ASV5542      2.343425e-03  2.444975e-03  2.550280e-03  2.659435e-03
## ASV0336     -2.718606e-03 -2.821125e-03 -2.927075e-03 -3.036579e-03
## ASV10102     4.526927e-03  4.707398e-03  4.893644e-03  5.085746e-03
## ASV16823    -2.329737e-03 -2.394582e-03 -2.460415e-03 -2.527230e-03
## ASV3104      2.329692e-03  2.394529e-03  2.460354e-03  2.527160e-03
## ASV0781      1.391887e-03  1.439534e-03  1.488564e-03  1.539028e-03
## ASV10899     2.645250e-03  2.782672e-03  2.926556e-03  3.077137e-03
## ASV11222    -2.329634e-03 -2.394462e-03 -2.460277e-03 -2.527071e-03
## ASV11327    -2.329587e-03 -2.394408e-03 -2.460215e-03 -2.527000e-03
## ASV12458    -2.329539e-03 -2.394353e-03 -2.460153e-03 -2.526930e-03
## ASV1636     -1.809068e-03 -1.855646e-03 -1.902801e-03 -1.950536e-03
## ASV1890     -2.622186e-03 -2.711292e-03 -2.803193e-03 -2.897996e-03
## ASV2898      6.229206e-03  6.439693e-03  6.655370e-03  6.876297e-03
## ASV8328      7.690018e-04  8.397719e-04  9.151473e-04  9.953355e-04
## ASV0709     -5.169498e-03 -5.344336e-03 -5.523314e-03 -5.706452e-03
## ASV0856      1.397474e-03  1.465750e-03  1.536983e-03  1.611262e-03
## ASV0909     -7.968914e-04 -7.762847e-04 -7.523708e-04 -7.249858e-04
## ASV0937     -4.959483e-03 -5.174104e-03 -5.397627e-03 -5.630391e-03
## ASV11390    -2.329399e-03 -2.394193e-03 -2.459971e-03 -2.526723e-03
## ASV11966     2.386354e-03  2.497850e-03  2.613860e-03  2.734506e-03
## ASV12990     9.110560e-04  9.443222e-04  9.785485e-04  1.013758e-03
## ASV14797     2.706282e-03  2.788901e-03  2.873200e-03  2.959198e-03
## ASV14904    -2.329322e-03 -2.394106e-03 -2.459871e-03 -2.526610e-03
## ASV15304     1.710767e-03  1.799096e-03  1.891315e-03  1.987535e-03
## ASV16696    -2.329267e-03 -2.394043e-03 -2.459801e-03 -2.526532e-03
## ASV1690      2.519872e-03  2.633715e-03  2.751547e-03  2.873412e-03
## ASV2029      8.484547e-03  8.790889e-03  9.105976e-03  9.429947e-03
## ASV2834      5.045508e-03  5.245842e-03  5.452929e-03  5.666915e-03
## ASV4003      2.740883e-03  2.892734e-03  3.052514e-03  3.220588e-03
## ASV4064      3.776330e-03  3.929441e-03  4.087735e-03  4.251327e-03
## ASV4294      2.198711e-03  2.317917e-03  2.443114e-03  2.574549e-03
## ASV4609      1.361447e-04  1.492331e-04  1.632164e-04  1.781405e-04
## ASV6283     -2.329160e-03 -2.393923e-03 -2.459667e-03 -2.526383e-03
## ASV6491     -2.329127e-03 -2.393887e-03 -2.459626e-03 -2.526338e-03
## ASV7453      2.281850e-03  2.398043e-03  2.519360e-03  2.645951e-03
## ASV7959      1.216916e-03  1.292037e-03  1.371109e-03  1.454289e-03
## ASV8219      2.329075e-03  2.393829e-03  2.459563e-03  2.526269e-03
## ASV8547     -2.329050e-03 -2.393802e-03 -2.459534e-03 -2.526237e-03
## ASV9319      2.667782e-03  2.786611e-03  2.910480e-03  3.039588e-03
## ASV9382     -2.329021e-03 -2.393771e-03 -2.459500e-03 -2.526201e-03
## ASV11516    -2.329003e-03 -2.393751e-03 -2.459479e-03 -2.526179e-03
## ASV14377    -2.328987e-03 -2.393735e-03 -2.459463e-03 -2.526162e-03
## ASV1867      5.266561e-03  5.481896e-03  5.704853e-03  5.935637e-03
## ASV1895     -7.771061e-04 -8.018483e-04 -8.274815e-04 -8.540586e-04
## ASV3168      1.545555e-03  1.584079e-03  1.622558e-03  1.660941e-03
## ASV4449      3.380125e-03  3.494752e-03  3.612641e-03  3.733881e-03
## ASV6596      3.552130e-03  3.731296e-03  3.918939e-03  4.115390e-03
## ASV7492     -7.871351e-05 -4.950282e-05 -1.777910e-05  1.656177e-05
## ASV9854     -1.065331e-03 -1.091117e-03 -1.117073e-03 -1.143183e-03
## ASV6296      2.328949e-03  2.393696e-03  2.459425e-03  2.526126e-03
## ASV4201      2.562792e-03  2.709276e-03  2.863308e-03  3.025198e-03
## ASV0552      8.942667e-03  9.309165e-03  9.688098e-03  1.007968e-02
## ASV3671      5.010925e-05  6.712023e-05  8.499827e-05  1.037285e-04
## ASV3529      2.786376e-04  3.126453e-04  3.485054e-04  3.862437e-04
## ASV1060      2.518228e-03  2.638996e-03  2.765684e-03  2.898581e-03
## ASV0239     -3.179704e-03 -3.256984e-03 -3.334304e-03 -3.411562e-03
## ASV5711     -3.414449e-03 -3.525284e-03 -3.638775e-03 -3.754953e-03
## ASV4152     -5.095858e-03 -5.277822e-03 -5.464788e-03 -5.656804e-03
## ASV1461      3.648683e-03  3.747942e-03  3.848386e-03  3.949991e-03
## ASV2877      3.568905e-03  3.685489e-03  3.804331e-03  3.925379e-03
## ASV0012      3.853137e-03  4.029249e-03  4.212637e-03  4.403522e-03
## ASV9823      5.668193e-04  5.702874e-04  5.728910e-04  5.745873e-04
## ASV0008      4.058246e-03  4.240795e-03  4.430818e-03  4.628546e-03
## ASV7832     -3.027400e-03 -3.135175e-03 -3.246099e-03 -3.360233e-03
## ASV1915      6.191929e-04  6.470343e-04  6.755108e-04  7.045817e-04
## ASV0055      2.197845e-03  2.272644e-03  2.348890e-03  2.426519e-03
## ASV0032      4.826102e-03  4.984324e-03  5.146361e-03  5.312286e-03
## ASV2977     -4.256683e-03 -4.406566e-03 -4.560371e-03 -4.718119e-03
## ASV0466      3.693342e-03  3.800358e-03  3.908739e-03  4.018404e-03
## ASV3866      5.469070e-03  5.698544e-03  5.937014e-03  6.184816e-03
## ASV0040      7.677099e-03  8.006087e-03  8.347534e-03  8.701773e-03
## ASV0496     -1.460848e-03 -1.553109e-03 -1.650347e-03 -1.752754e-03
## ASV0052      7.410319e-03  7.666305e-03  7.928531e-03  8.197018e-03
## ASV3828     -4.600116e-03 -4.773174e-03 -4.952171e-03 -5.137306e-03
## ASV1930      2.959333e-03  3.061229e-03  3.165399e-03  3.271828e-03
## ASV2126      4.773563e-03  4.944933e-03  5.120997e-03  5.301807e-03
## ASV0793      4.186719e-03  4.382735e-03  4.586881e-03  4.799401e-03
## ASV0299     -1.196449e-03 -1.223219e-03 -1.250681e-03 -1.278938e-03
## ASV0208      5.846945e-03  6.114909e-03  6.394478e-03  6.686089e-03
## ASV0511     -1.125053e-03 -1.125106e-03 -1.123241e-03 -1.119393e-03
## ASV1123     -2.301346e-03 -2.357121e-03 -2.413002e-03 -2.468922e-03
## ASV0099     -1.261579e-03 -1.277448e-03 -1.291014e-03 -1.302010e-03
## ASV0752     -8.015175e-04 -8.423661e-04 -8.849367e-04 -9.292765e-04
## ASV0883      3.409126e-04  3.618822e-04  3.838782e-04  4.069306e-04
## ASV0683      5.020109e-03  5.239166e-03  5.466742e-03  5.703079e-03
## ASV4117     -4.653062e-03 -4.826071e-03 -5.004627e-03 -5.188866e-03
## ASV2172      1.939366e-03  2.016667e-03  2.096716e-03  2.179594e-03
## ASV0330     -3.525019e-03 -3.662719e-03 -3.804943e-03 -3.951801e-03
## ASV0728      3.832291e-03  3.995194e-03  4.164084e-03  4.339124e-03
## ASV0499      7.764453e-03  8.115272e-03  8.480786e-03  8.861496e-03
## ASV0120     -6.766490e-03 -7.007674e-03 -7.254958e-03 -7.508346e-03
## ASV1446     -2.881661e-04 -3.313135e-04 -3.781028e-04 -4.287716e-04
## ASV17171    -4.560234e-03 -4.735942e-03 -4.917764e-03 -5.105885e-03
## ASV0533      1.808572e-03  1.895168e-03  1.985649e-03  2.080154e-03
## ASV2495     -2.451538e-03 -2.569136e-03 -2.692106e-03 -2.820641e-03
## ASV5582      9.507425e-04  9.646904e-04  9.779349e-04  9.904164e-04
## ASV1488      1.853489e-03  1.932002e-03  2.013189e-03  2.097085e-03
## ASV0682      5.331231e-03  5.567289e-03  5.812751e-03  6.067891e-03
## ASV0068     -1.026249e-03 -1.085053e-03 -1.146290e-03 -1.209971e-03
## ASV1987     -3.471122e-03 -3.641284e-03 -3.819238e-03 -4.005283e-03
## ASV0035     -9.182512e-04 -1.026917e-03 -1.144445e-03 -1.271383e-03
## ASV7192     -2.382525e-03 -2.446535e-03 -2.510911e-03 -2.575570e-03
## ASV0873     -1.075933e-04 -1.246954e-04 -1.426996e-04 -1.616077e-04
## ASV4749     -1.150705e-03 -1.244302e-03 -1.343848e-03 -1.449613e-03
## ASV2174      2.148268e-03  2.208913e-03  2.270992e-03  2.334594e-03
## ASV1476     -2.927898e-03 -3.054526e-03 -3.186213e-03 -3.323118e-03
## ASV0740     -7.580198e-03 -7.910244e-03 -8.253203e-03 -8.609459e-03
## ASV0170      1.427986e-03  1.486239e-03  1.546655e-03  1.609305e-03
## ASV2466     -5.973259e-03 -6.215067e-03 -6.465906e-03 -6.726075e-03
## ASV1709      4.222052e-03  4.374004e-03  4.530176e-03  4.690616e-03
## ASV6170     -4.516683e-03 -4.700345e-03 -4.890396e-03 -5.086984e-03
## ASV3673      5.223438e-03  5.437797e-03  5.659747e-03  5.889470e-03
## ASV1745      3.955827e-04  4.100759e-04  4.248536e-04  4.398968e-04
##                                                                    
## (Intercept) -3.775073e-03 -4.087765e-03 -4.421048e-03 -4.775823e-03
## ASV1236      3.139406e-03  3.233231e-03  3.328827e-03  3.426197e-03
## ASV0421     -5.760526e-03 -5.935299e-03 -6.113448e-03 -6.294988e-03
## ASV0691     -4.197768e-03 -4.306629e-03 -4.417047e-03 -4.529035e-03
## ASV0899      3.450660e-04  3.601456e-04  3.752625e-04  3.903770e-04
## ASV1004      6.499730e-03  6.691100e-03  6.885482e-03  7.082820e-03
## ASV1041     -4.300627e-03 -4.419366e-03 -4.539268e-03 -4.660257e-03
## ASV1058      6.238842e-03  6.435761e-03  6.637013e-03  6.842638e-03
## ASV12542     1.489943e-03  1.526718e-03  1.564019e-03  1.601864e-03
## ASV1294      7.688816e-03  7.943056e-03  8.203301e-03  8.469605e-03
## ASV13113     4.070021e-03  4.257683e-03  4.453469e-03  4.657678e-03
## ASV1318      6.264913e-03  6.457131e-03  6.653033e-03  6.852614e-03
## ASV2269     -1.839200e-03 -1.893051e-03 -1.947696e-03 -2.003115e-03
## ASV2542      5.656746e-03  5.894091e-03  6.140211e-03  6.395342e-03
## ASV2660     -3.287285e-03 -3.378812e-03 -3.471698e-03 -3.565935e-03
## ASV2737     -4.403524e-04 -4.583590e-04 -4.767262e-04 -4.954372e-04
## ASV2840      4.086164e-03  4.186023e-03  4.286324e-03  4.386997e-03
## ASV3053      2.078714e-04  2.156453e-04  2.238600e-04  2.325450e-04
## ASV3077      1.455944e-03  1.502468e-03  1.550210e-03  1.599200e-03
## ASV3134      7.905250e-03  8.262164e-03  8.634171e-03  9.021812e-03
## ASV3140      2.968251e-03  3.081427e-03  3.197954e-03  3.317874e-03
## ASV3579      2.125015e-03  2.236724e-03  2.353477e-03  2.475407e-03
## ASV6119     -1.838237e-03 -1.892041e-03 -1.946649e-03 -2.002046e-03
## ASV7557     -1.838138e-03 -1.891943e-03 -1.946555e-03 -2.001957e-03
## ASV8422      8.796084e-04  9.053351e-04  9.317084e-04  9.587490e-04
## ASV1086     -4.597249e-04 -4.750193e-04 -4.908861e-04 -5.073531e-04
## ASV1310      3.729635e-03  3.843663e-03  3.959273e-03  4.076366e-03
## ASV15750    -7.119661e-04 -7.260581e-04 -7.398757e-04 -7.533862e-04
## ASV16905    -1.838024e-03 -1.891859e-03 -1.946511e-03 -2.001966e-03
## ASV2033      5.029992e-03  5.237578e-03  5.452226e-03  5.674070e-03
## ASV2089      1.273720e-03  1.310531e-03  1.347808e-03  1.385535e-03
## ASV2127      5.288919e-03  5.458298e-03  5.631328e-03  5.808012e-03
## ASV2725      5.177968e-03  5.317780e-03  5.459272e-03  5.602403e-03
## ASV2804     -1.838051e-03 -1.891919e-03 -1.946611e-03 -2.002114e-03
## ASV3075      4.419944e-03  4.595467e-03  4.777637e-03  4.966691e-03
## ASV3327      4.798831e-03  4.997992e-03  5.204288e-03  5.417897e-03
## ASV3342      4.760039e-03  4.943927e-03  5.133731e-03  5.329577e-03
## ASV3532     -4.374764e-03 -4.552670e-03 -4.737362e-03 -4.929095e-03
## ASV3600      5.346010e-03  5.551214e-03  5.762940e-03  5.981312e-03
## ASV4013      3.809027e-03  3.931147e-03  4.055640e-03  4.182466e-03
## ASV4136      3.472417e-03  3.580361e-03  3.690750e-03  3.803620e-03
## ASV4195      1.838183e-03  1.892100e-03  1.946849e-03  2.002418e-03
## ASV4407     -1.838233e-03 -1.892163e-03 -1.946927e-03 -2.002515e-03
## ASV4717     -1.112226e-04 -1.176764e-04 -1.241886e-04 -1.307393e-04
## ASV6794      1.688139e-03  1.739969e-03  1.793261e-03  1.848070e-03
## ASV8324     -1.838421e-03 -1.892392e-03 -1.947205e-03 -2.002847e-03
## ASV8981      9.938979e-05  1.268789e-04  1.565010e-04  1.883403e-04
## ASV9859      2.936053e-03  3.092999e-03  3.258050e-03  3.431576e-03
## ASV0936     -3.129175e-03 -3.232973e-03 -3.339257e-03 -3.448048e-03
## ASV12683    -4.858187e-04 -5.036028e-04 -5.217023e-04 -5.401013e-04
## ASV1293      4.243848e-03  4.372918e-03  4.504527e-03  4.638686e-03
## ASV13055    -2.281764e-04 -2.256228e-04 -2.223800e-04 -2.184093e-04
## ASV17063    -1.838837e-03 -1.892878e-03 -1.947766e-03 -2.003489e-03
## ASV2228      1.838912e-03  1.892964e-03  1.947863e-03  2.003597e-03
## ASV2769      8.677334e-05  1.017685e-04  1.174595e-04  1.338271e-04
## ASV2803      6.795367e-04  6.970472e-04  7.149198e-04  7.331727e-04
## ASV2896      3.281524e-03  3.431936e-03  3.589530e-03  3.754664e-03
## ASV3062      1.679500e-03  1.767967e-03  1.860438e-03  1.957024e-03
## ASV3107      3.618157e-03  3.761696e-03  3.910185e-03  4.063743e-03
## ASV3265      5.433714e-03  5.593848e-03  5.756627e-03  5.922015e-03
## ASV3666     -2.835642e-04 -2.993323e-04 -3.159310e-04 -3.333923e-04
## ASV4497      1.344804e-03  1.387211e-03  1.430540e-03  1.474802e-03
## ASV6914     -8.120122e-04 -8.416004e-04 -8.720141e-04 -9.032645e-04
## ASV0576     -5.751595e-03 -5.908948e-03 -6.068879e-03 -6.231410e-03
## ASV0673      2.505674e-03  2.601569e-03  2.699927e-03  2.800741e-03
## ASV0772      2.391618e-03  2.482373e-03  2.576147e-03  2.673020e-03
## ASV0862     -1.015815e-03 -1.027564e-03 -1.038591e-03 -1.048880e-03
## ASV0898      2.618278e-03  2.729093e-03  2.843613e-03  2.961894e-03
## ASV0910      5.405447e-03  5.637777e-03  5.878724e-03  6.128513e-03
## ASV0964     -2.108917e-03 -2.163133e-03 -2.217797e-03 -2.272888e-03
## ASV10059     2.778785e-03  2.909100e-03  3.045062e-03  3.186874e-03
## ASV10263    -1.839838e-03 -1.894010e-03 -1.949037e-03 -2.004906e-03
## ASV1088      3.176371e-03  3.328593e-03  3.487684e-03  3.653898e-03
## ASV1101      3.370377e-03  3.467499e-03  3.565336e-03  3.663756e-03
## ASV1183      2.506398e-03  2.598592e-03  2.693529e-03  2.791261e-03
## ASV11956     5.206960e-04  5.317172e-04  5.429505e-04  5.544187e-04
## ASV12774    -4.903378e-04 -5.120549e-04 -5.345732e-04 -5.579100e-04
## ASV1321      1.991562e-03  2.095305e-03  2.203600e-03  2.316566e-03
## ASV13793    -1.840128e-03 -1.894326e-03 -1.949379e-03 -2.005274e-03
## ASV14482    -3.106549e-04 -3.210109e-04 -3.314097e-04 -3.418286e-04
## ASV15483     1.770218e-03  1.841684e-03  1.915601e-03  1.992029e-03
## ASV2062      9.370510e-03  9.697471e-03  1.003295e-02  1.037702e-02
## ASV2132      5.056510e-03  5.260785e-03  5.472036e-03  5.690412e-03
## ASV2413      5.543002e-03  5.725592e-03  5.912716e-03  6.104441e-03
## ASV2490      3.150751e-03  3.236570e-03  3.323484e-03  3.411466e-03
## ASV2594      2.574873e-03  2.689200e-03  2.808690e-03  2.933572e-03
## ASV2822     -1.840423e-03 -1.894653e-03 -1.949740e-03 -2.005671e-03
## ASV2863      3.178734e-03  3.276672e-03  3.376712e-03  3.478877e-03
## ASV2910      4.056694e-03  4.178388e-03  4.302514e-03  4.429100e-03
## ASV2980      1.394926e-03  1.430982e-03  1.467262e-03  1.503736e-03
## ASV3307      1.840637e-03  1.894888e-03  1.950000e-03  2.005958e-03
## ASV3474      4.480794e-03  4.672932e-03  4.871845e-03  5.077648e-03
## ASV3502      7.212447e-03  7.480493e-03  7.757080e-03  8.042437e-03
## ASV4236      2.786181e-03  2.862747e-03  2.940413e-03  3.019176e-03
## ASV4842     -1.021046e-03 -1.049146e-03 -1.077435e-03 -1.105882e-03
## ASV4894     -1.840839e-03 -1.895115e-03 -1.950255e-03 -2.006247e-03
## ASV5290      2.605966e-03  2.692770e-03  2.781360e-03  2.871720e-03
## ASV5501      6.146774e-04  6.445917e-04  6.760466e-04  7.091180e-04
## ASV5795      2.197492e-03  2.287918e-03  2.381390e-03  2.477957e-03
## ASV5987     -1.841040e-03 -1.895344e-03 -1.950516e-03 -2.006545e-03
## ASV6267     -1.841107e-03 -1.895421e-03 -1.950604e-03 -2.006646e-03
## ASV6862      3.121534e-03  3.208583e-03  3.297250e-03  3.387565e-03
## ASV7145      6.103642e-04  6.335836e-04  6.578452e-04  6.831996e-04
## ASV7673     -1.841271e-03 -1.895609e-03 -1.950821e-03 -2.006897e-03
## ASV7789      1.779480e-03  1.878911e-03  1.983300e-03  2.092829e-03
## ASV7809      2.597933e-04  2.850277e-04  3.116955e-04  3.398297e-04
## ASV8002     -1.841491e-03 -1.895864e-03 -1.951118e-03 -2.007243e-03
## ASV8205      1.423230e-03  1.483035e-03  1.545162e-03  1.609679e-03
## ASV9155     -1.310465e-03 -1.346010e-03 -1.381917e-03 -1.418168e-03
## ASV9221      4.341853e-04  4.741535e-04  5.167125e-04  5.619732e-04
## ASV9311     -1.841860e-03 -1.896296e-03 -1.951622e-03 -2.007832e-03
## ASV9557     -1.841972e-03 -1.896426e-03 -1.951774e-03 -2.008009e-03
## ASV9936     -1.842088e-03 -1.896561e-03 -1.951933e-03 -2.008194e-03
## ASV1445      5.699013e-03  5.929107e-03  6.167365e-03  6.414008e-03
## ASV4232      5.723364e-03  5.992136e-03  6.273137e-03  6.566867e-03
## ASV6479      1.012205e-03  1.084870e-03  1.161802e-03  1.243179e-03
## ASV0142     -8.912108e-03 -9.172840e-03 -9.438125e-03 -9.707951e-03
## ASV0378     -2.299786e-03 -2.338166e-03 -2.375164e-03 -2.410663e-03
## ASV1122      7.430243e-03  7.720642e-03  8.020345e-03  8.329520e-03
## ASV0123     -8.672369e-03 -8.923475e-03 -9.178766e-03 -9.438213e-03
## ASV2064      6.119630e-04  6.219890e-04  6.319544e-04  6.418758e-04
## ASV4459     -9.447454e-04 -9.721027e-04 -1.000049e-03 -1.028607e-03
## ASV0448      3.250365e-03  3.410191e-03  3.576883e-03  3.750644e-03
## ASV0397      5.167607e-03  5.357978e-03  5.553865e-03  5.755347e-03
## ASV0485      6.861629e-03  7.112422e-03  7.370997e-03  7.637543e-03
## ASV1566      5.973033e-03  6.189873e-03  6.412817e-03  6.641950e-03
## ASV1365      3.948077e-03  4.090949e-03  4.237476e-03  4.387653e-03
## ASV1065      8.132402e-03  8.438416e-03  8.753838e-03  9.078838e-03
## ASV0722     -7.049633e-05 -7.481122e-05 -7.967934e-05 -8.516025e-05
## ASV12660    -2.844912e-03 -2.925485e-03 -3.007331e-03 -3.090442e-03
## ASV0223      5.866977e-05  7.164979e-05  8.593748e-05  1.016267e-04
## ASV0229      4.124853e-03  4.298001e-03  4.477673e-03  4.664065e-03
## ASV0877     -7.675636e-04 -7.831448e-04 -7.989425e-04 -8.149898e-04
## ASV0983      6.517060e-03  6.733993e-03  6.956160e-03  7.183602e-03
## ASV0626     -9.943968e-04 -9.970512e-04 -9.986601e-04 -9.992209e-04
## ASV4146     -3.578832e-04 -3.760981e-04 -3.957672e-04 -4.170296e-04
## ASV4175     -4.414405e-03 -4.572117e-03 -4.734036e-03 -4.900195e-03
## ASV2082     -1.229015e-03 -1.308880e-03 -1.393271e-03 -1.482372e-03
## ASV2272      3.748025e-03  3.904634e-03  4.066897e-03  4.234943e-03
## ASV2245     -4.058926e-03 -4.212772e-03 -4.371456e-03 -4.535086e-03
## ASV0590     -3.595419e-03 -3.766117e-03 -3.943911e-03 -4.129008e-03
## ASV0217     -6.491761e-04 -5.892412e-04 -5.235977e-04 -4.520334e-04
## ASV0416      2.136961e-03  2.171700e-03  2.205160e-03  2.237214e-03
## ASV1056      5.443752e-03  5.671356e-03  5.906512e-03  6.149323e-03
## ASV7777     -3.997882e-03 -4.153973e-03 -4.315673e-03 -4.483188e-03
## ASV0455      1.002626e-03  1.038731e-03  1.075318e-03  1.112325e-03
## ASV0604      1.791574e-03  1.883169e-03  1.978648e-03  2.078117e-03
## ASV6100     -3.808618e-03 -3.961934e-03 -4.121043e-03 -4.286163e-03
## ASV11359    -3.770264e-03 -3.898841e-03 -4.030448e-03 -4.165084e-03
## ASV6604      3.385941e-03  3.530278e-03  3.680054e-03  3.835414e-03
## ASV5004     -2.261871e-03 -2.345182e-03 -2.431260e-03 -2.520204e-03
## ASV1483     -2.155420e-03 -2.235026e-03 -2.317055e-03 -2.401552e-03
## ASV9773     -4.752494e-03 -4.937237e-03 -5.128389e-03 -5.326150e-03
## ASV4059      1.114376e-03  1.176571e-03  1.241635e-03  1.309641e-03
## ASV1193      7.375776e-03  7.644386e-03  7.920660e-03  8.204698e-03
## ASV4610      2.935725e-04  3.233657e-04  3.543141e-04  3.863771e-04
## ASV0742     -1.186538e-03 -1.189097e-03 -1.190220e-03 -1.189890e-03
## ASV1502     -5.739900e-04 -6.094605e-04 -6.466035e-04 -6.854585e-04
## ASV0195     -1.432422e-03 -1.501733e-03 -1.573943e-03 -1.649148e-03
## ASV1213      1.470033e-03  1.495985e-03  1.521136e-03  1.545400e-03
## ASV1648     -3.491730e-03 -3.629921e-03 -3.773319e-03 -3.922128e-03
## ASV6984     -2.806054e-03 -2.924395e-03 -3.047653e-03 -3.176041e-03
## ASV0396      3.119820e-04  3.811840e-04  4.546597e-04  5.324846e-04
## ASV4297      2.954389e-03  3.040161e-03  3.127455e-03  3.216272e-03
## ASV2622      7.316590e-03  7.549822e-03  7.788483e-03  8.032651e-03
## ASV3512      2.616932e-03  2.762790e-03  2.916355e-03  3.077978e-03
## ASV2411      3.762334e-03  3.923320e-03  4.089989e-03  4.262427e-03
## ASV2291     -1.485832e-03 -1.564693e-03 -1.647182e-03 -1.733409e-03
## ASV0807      5.063409e-03  5.291513e-03  5.528117e-03  5.773400e-03
## ASV1292      1.753157e-03  1.816314e-03  1.881666e-03  1.949307e-03
## ASV1035      6.234177e-04  6.436134e-04  6.646259e-04  6.865054e-04
## ASV0070     -4.049586e-04 -3.627671e-04 -3.158961e-04 -2.640929e-04
## ASV0255      6.122787e-04  6.160175e-04  6.178505e-04  6.175504e-04
## ASV0057     -6.133383e-03 -6.267713e-03 -6.400755e-03 -6.532230e-03
## ASV0077      3.096526e-05  7.118219e-05  1.142848e-04  1.603295e-04
## ASV0625      7.020349e-03  7.220133e-03  7.422661e-03  7.627842e-03
## ASV2464      3.186755e-03  3.275107e-03  3.364814e-03  3.455866e-03
## ASV1315      9.408659e-03  9.805834e-03  1.021729e-02  1.064335e-02
## ASV2673      7.377467e-03  7.713801e-03  8.064420e-03  8.429836e-03
## ASV2161      3.153227e-03  3.300004e-03  3.453114e-03  3.612779e-03
## ASV0337     -3.369487e-03 -3.479960e-03 -3.592879e-03 -3.708253e-03
## ASV7680     -4.639073e-03 -4.819179e-03 -5.005249e-03 -5.197421e-03
## ASV0611      1.123951e-02  1.171999e-02  1.221921e-02  1.273776e-02
## ASV3118     -3.605317e-03 -3.748845e-03 -3.897177e-03 -4.050412e-03
## ASV1284      3.840013e-03  3.993789e-03  4.152616e-03  4.316571e-03
## ASV0889      2.492733e-03  2.586985e-03  2.684620e-03  2.785772e-03
## ASV4649     -2.737662e-03 -2.839230e-03 -2.943906e-03 -3.051752e-03
## ASV1108     -4.636536e-03 -4.847079e-03 -5.066237e-03 -5.294270e-03
## ASV0738      1.972737e-03  2.127396e-03  2.291519e-03  2.465534e-03
## ASV0473      6.860686e-04  7.178732e-04  7.510538e-04  7.856590e-04
## ASV0598     -2.591819e-03 -2.647394e-03 -2.702547e-03 -2.757177e-03
## ASV0429      5.667196e-03  5.852579e-03  6.042052e-03  6.235625e-03
## ASV1549      8.294274e-03  8.666803e-03  9.054103e-03  9.456567e-03
## ASV1203      4.531472e-03  4.687842e-03  4.847992e-03  5.011919e-03
## ASV4532      8.139439e-05  8.868124e-05  9.700345e-05  1.064729e-04
## ASV0274     -3.318016e-03 -3.400981e-03 -3.484789e-03 -3.569443e-03
## ASV0163     -4.560039e-03 -4.664822e-03 -4.769854e-03 -4.875068e-03
## ASV1298      2.019800e-03  2.081048e-03  2.144200e-03  2.209373e-03
## ASV9424     -6.518282e-03 -6.786136e-03 -7.063937e-03 -7.351994e-03
## ASV0412      8.416002e-03  8.709148e-03  9.009951e-03  9.318482e-03
## ASV0284      2.918327e-03  2.991887e-03  3.065616e-03  3.139399e-03
## ASV0620     -3.895937e-03 -4.064679e-03 -4.239640e-03 -4.420970e-03
## ASV0153     -7.328289e-03 -7.626949e-03 -7.935360e-03 -8.253642e-03
## ASV0498      2.243268e-03  2.360479e-03  2.481895e-03  2.607501e-03
## ASV0097      5.773894e-03  6.034361e-03  6.305517e-03  6.587697e-03
## ASV0104     -1.997292e-02 -2.068309e-02 -2.141252e-02 -2.216144e-02
## ASV1282      3.781080e-03  3.919106e-03  4.060513e-03  4.205260e-03
## ASV3883     -2.535075e-03 -2.635803e-03 -2.739315e-03 -2.845583e-03
## ASV0801      2.970712e-03  3.108842e-03  3.252873e-03  3.403021e-03
## ASV1611     -8.814183e-03 -9.168832e-03 -9.535758e-03 -9.915253e-03
## ASV0227     -4.180230e-03 -4.374322e-03 -4.576444e-03 -4.786856e-03
## ASV0833      4.339306e-03  4.532010e-03  4.731812e-03  4.938860e-03
## ASV0718      7.628401e-03  7.913397e-03  8.206655e-03  8.508261e-03
## ASV1139      1.145997e-03  1.135466e-03  1.121589e-03  1.104168e-03
## ASV0766     -1.620634e-03 -1.669611e-03 -1.719673e-03 -1.770843e-03
## ASV2091      7.717796e-03  7.938651e-03  8.163016e-03  8.390863e-03
## ASV1238      5.937240e-04  6.501296e-04  7.096566e-04  7.723671e-04
## ASV9193     -1.929759e-03 -2.029062e-03 -2.132437e-03 -2.239952e-03
## ASV0290     -1.310763e-03 -1.360803e-03 -1.411372e-03 -1.462338e-03
## ASV0231      7.566701e-03  7.834955e-03  8.110304e-03  8.392797e-03
## ASV0185      5.546421e-03  5.895255e-03  6.263361e-03  6.651558e-03
## ASV2330      1.854403e-03  1.912707e-03  1.972482e-03  2.033779e-03
## ASV3119     -4.258536e-03 -4.471840e-03 -4.694825e-03 -4.927831e-03
## ASV2368     -4.675701e-03 -4.893289e-03 -5.120649e-03 -5.358175e-03
## ASV0122     -2.046275e-03 -2.101837e-03 -2.158364e-03 -2.215895e-03
## ASV1044      6.787878e-03  7.099691e-03  7.424320e-03  7.762162e-03
## ASV0160     -4.449157e-03 -4.541225e-03 -4.632778e-03 -4.723742e-03
## ASV0326      4.533733e-03  4.696098e-03  4.862547e-03  5.033072e-03
## ASV1388      7.758826e-03  8.042345e-03  8.334310e-03  8.634883e-03
## ASV0792      7.776481e-03  8.020352e-03  8.268739e-03  8.521573e-03
## ASV0036     -6.289602e-03 -6.531599e-03 -6.780335e-03 -7.035787e-03
## ASV2125      8.923297e-03  9.236682e-03  9.557959e-03  9.887142e-03
## ASV1075      2.313117e-03  2.417548e-03  2.526220e-03  2.639261e-03
## ASV0390      3.277047e-03  3.458468e-03  3.649526e-03  3.850666e-03
## ASV3790     -8.040150e-03 -8.356809e-03 -8.684030e-03 -9.022052e-03
## ASV1535     -1.223526e-03 -1.289112e-03 -1.357673e-03 -1.429278e-03
## ASV0263      1.625244e-03  1.688876e-03  1.754700e-03  1.822775e-03
## ASV0675      1.487288e-02  1.550996e-02  1.617091e-02  1.685633e-02
## ASV3348      1.862649e-03  1.956597e-03  2.054944e-03  2.157862e-03
## ASV0058     -1.075760e-02 -1.111560e-02 -1.148135e-02 -1.185480e-02
## ASV4142      2.543397e-03  2.624435e-03  2.707324e-03  2.792100e-03
## ASV0059     -9.065970e-03 -9.358612e-03 -9.656898e-03 -9.960733e-03
## ASV0013     -2.036519e-02 -2.109570e-02 -2.184666e-02 -2.261836e-02
## ASV0033     -7.057502e-03 -7.339457e-03 -7.630237e-03 -7.929923e-03
## ASV4354     -2.343830e-03 -2.425533e-03 -2.509686e-03 -2.596340e-03
## ASV0022     -7.286729e-03 -7.570397e-03 -7.862280e-03 -8.162385e-03
## ASV0134     -2.385184e-03 -2.500322e-03 -2.620848e-03 -2.747016e-03
## ASV0415     -6.905382e-05 -3.820118e-05 -5.033240e-06  3.051933e-05
## ASV10103    -4.915643e-03 -5.106739e-03 -5.303851e-03 -5.507070e-03
## ASV1613      6.264670e-03  6.454225e-03  6.646633e-03  6.841783e-03
## ASV0135      1.703202e-03  1.840086e-03  1.985651e-03  2.140302e-03
## ASV0469     -7.966297e-03 -8.228216e-03 -8.496647e-03 -8.771696e-03
## ASV0471      6.072414e-03  6.307910e-03  6.551564e-03  6.803638e-03
## ASV0451     -2.483155e-03 -2.601519e-03 -2.724667e-03 -2.852712e-03
## ASV0747      3.191260e-03  3.332098e-03  3.477848e-03  3.628568e-03
## ASV1314     -5.115916e-03 -5.370630e-03 -5.637604e-03 -5.917359e-03
## ASV0425     -7.837365e-03 -8.048695e-03 -8.262471e-03 -8.478623e-03
## ASV0559     -4.892160e-03 -5.059783e-03 -5.233107e-03 -5.412389e-03
## ASV0148     -4.399713e-03 -4.492324e-03 -4.583471e-03 -4.672910e-03
## ASV0129     -9.695698e-04 -9.303534e-04 -8.856366e-04 -8.351284e-04
## ASV1072      1.938148e-03  1.971183e-03  2.003201e-03  2.034128e-03
## ASV2390      1.310612e-03  1.326523e-03  1.341009e-03  1.353970e-03
## ASV0548      7.177147e-03  7.455994e-03  7.743846e-03  8.040889e-03
## ASV0168     -9.111116e-03 -9.421493e-03 -9.740203e-03 -1.006741e-02
## ASV0066     -6.849253e-03 -7.073724e-03 -7.302686e-03 -7.536056e-03
## ASV0468     -2.893339e-03 -3.009215e-03 -3.129566e-03 -3.254577e-03
## ASV0172      4.366347e-04  5.169604e-04  6.031904e-04  6.955748e-04
## ASV0236     -1.180068e-03 -1.140026e-03 -1.094557e-03 -1.043431e-03
## ASV0250      3.527877e-03  3.773606e-03  4.033704e-03  4.308793e-03
## ASV0338      7.778455e-04  8.371423e-04  8.991762e-04  9.639839e-04
## ASV0450     -4.591959e-05 -5.204928e-05 -5.905050e-05 -6.702215e-05
## ASV0377      8.118810e-03  8.408816e-03  8.706309e-03  9.011296e-03
## ASV1022      2.581203e-03  2.690928e-03  2.805110e-03  2.923916e-03
## ASV6174     -5.321702e-04 -5.536154e-04 -5.758246e-04 -5.987965e-04
## ASV0786      5.331814e-04  5.429086e-04  5.525208e-04  5.620102e-04
## ASV0053     -1.000120e-02 -1.036894e-02 -1.074721e-02 -1.113614e-02
## ASV0697     -1.842874e-03 -1.880492e-03 -1.917729e-03 -1.954539e-03
## ASV0785      7.398596e-03  7.673886e-03  7.957830e-03  8.250660e-03
## ASV1967     -3.831210e-03 -3.945917e-03 -4.062853e-03 -4.182022e-03
## ASV0385     -1.353252e-03 -1.378314e-03 -1.403136e-03 -1.427713e-03
## ASV0295      1.860014e-03  1.994610e-03  2.137308e-03  2.288461e-03
## ASV0072     -5.890691e-03 -6.035365e-03 -6.179827e-03 -6.323842e-03
## ASV0157     -1.369596e-03 -1.342627e-03 -1.309294e-03 -1.269114e-03
## ASV0501      4.846346e-03  5.063370e-03  5.288683e-03  5.522470e-03
## ASV10729    -6.442937e-03 -6.690001e-03 -6.944632e-03 -7.206939e-03
## ASV1470      2.286392e-03  2.348655e-03  2.411264e-03  2.474127e-03
## ASV0050     -1.822731e-02 -1.884292e-02 -1.947321e-02 -2.011825e-02
## ASV0411      2.813915e-04  3.152959e-04  3.511153e-04  3.888534e-04
## ASV0549      4.944496e-03  5.169371e-03  5.403573e-03  5.647404e-03
## ASV0184      2.493442e-03  2.597740e-03  2.706196e-03  2.818953e-03
## ASV0705      3.098229e-03  3.214482e-03  3.333714e-03  3.455898e-03
## ASV1715      7.381617e-03  7.666430e-03  7.960451e-03  8.263875e-03
## ASV0603      1.316054e-03  1.388986e-03  1.466131e-03  1.547716e-03
## ASV0826      1.707805e-03  1.750835e-03  1.794086e-03  1.837520e-03
## ASV0034     -7.404279e-03 -7.619104e-03 -7.836558e-03 -8.056489e-03
## ASV0838      1.457867e-03  1.487754e-03  1.516425e-03  1.543687e-03
## ASV0614     -4.483962e-03 -4.626656e-03 -4.771999e-03 -4.919935e-03
## ASV0014     -1.795313e-02 -1.857272e-02 -1.920817e-02 -1.985962e-02
## ASV0585     -1.289527e-03 -1.335020e-03 -1.381325e-03 -1.428387e-03
## ASV0016     -1.846965e-02 -1.911122e-02 -1.976948e-02 -2.044460e-02
## ASV5394     -5.151150e-03 -5.339717e-03 -5.533083e-03 -5.731200e-03
## ASV0666      3.888187e-03  4.018057e-03  4.150887e-03  4.286681e-03
## ASV2085     -3.007822e-05 -7.888566e-05 -1.314222e-04 -1.878315e-04
## ASV0003     -1.656252e-02 -1.712780e-02 -1.770731e-02 -1.830120e-02
## ASV0346      1.394722e-03  1.494467e-03  1.599327e-03  1.709440e-03
## ASV0267     -1.591510e-03 -1.612714e-03 -1.632987e-03 -1.652320e-03
## ASV0353      5.847127e-03  6.129209e-03  6.423407e-03  6.730091e-03
## ASV2419      4.529095e-03  4.680361e-03  4.835214e-03  4.993655e-03
## ASV0447      4.319054e-03  4.532388e-03  4.754640e-03  4.986053e-03
## ASV0654      8.415348e-03  8.730410e-03  9.054144e-03  9.386596e-03
## ASV0151      2.834797e-03  2.999695e-03  3.173340e-03  3.356090e-03
## ASV0065     -6.704943e-03 -6.927779e-03 -7.155390e-03 -7.387742e-03
## ASV0527      5.033956e-03  5.210541e-03  5.391653e-03  5.577317e-03
## ASV4055     -2.817071e-03 -2.959534e-03 -3.109363e-03 -3.266939e-03
## ASV0166     -4.765602e-03 -4.902933e-03 -5.042397e-03 -5.183969e-03
## ASV0417     -4.601533e-03 -4.758629e-03 -4.919922e-03 -5.085488e-03
## ASV0078     -2.826445e-03 -2.877923e-03 -2.927103e-03 -2.973694e-03
## ASV0322     -3.631249e-03 -3.717509e-03 -3.803527e-03 -3.889179e-03
## ASV0156     -5.678342e-03 -5.867452e-03 -6.061413e-03 -6.260316e-03
## ASV0648     -6.588943e-03 -6.856000e-03 -7.132302e-03 -7.418064e-03
## ASV0407      1.051941e-03  1.111608e-03  1.174326e-03  1.240218e-03
## ASV2030     -8.859876e-04 -9.203203e-04 -9.565757e-04 -9.948928e-04
## ASV0300      4.887027e-03  5.109446e-03  5.340331e-03  5.579852e-03
## ASV1150      1.867721e-04  2.151913e-04  2.456283e-04  2.781526e-04
## ASV0958      5.534762e-03  5.817480e-03  6.114147e-03  6.425364e-03
## ASV0216     -4.993264e-03 -5.157213e-03 -5.326186e-03 -5.500403e-03
## ASV0446      1.055339e-02  1.099816e-02  1.145855e-02  1.193490e-02
## ASV0367     -2.813468e-03 -2.915323e-03 -3.020251e-03 -3.128324e-03
## ASV0200     -5.640418e-03 -5.857501e-03 -6.081708e-03 -6.313206e-03
## ASV0334     -7.448208e-04 -7.179455e-04 -6.881426e-04 -6.553491e-04
## ASV1311      3.384953e-03  3.491830e-03  3.600640e-03  3.711337e-03
## ASV0458      4.053530e-03  4.203150e-03  4.357333e-03  4.516165e-03
## ASV1371      2.055159e-04  2.145355e-04  2.237919e-04  2.332755e-04
## ASV0418      5.281162e-03  5.487759e-03  5.701524e-03  5.922658e-03
## ASV0004      5.851379e-03  6.059297e-03  6.272735e-03  6.491734e-03
## ASV1943      3.926439e-03  4.060043e-03  4.197065e-03  4.337537e-03
## ASV1495     -2.476201e-03 -2.617232e-03 -2.765595e-03 -2.921591e-03
## ASV0901     -8.211597e-03 -8.564672e-03 -8.931560e-03 -9.312700e-03
## ASV0628      3.100255e-03  3.175448e-03  3.249869e-03  3.323282e-03
## ASV0400      1.219630e-03  1.245639e-03  1.270750e-03  1.294797e-03
## ASV0116     -6.866616e-03 -7.173385e-03 -7.492399e-03 -7.824017e-03
## ASV0788      4.491386e-03  4.659378e-03  4.832315e-03  5.010263e-03
## ASV0117      4.086610e-03  4.283041e-03  4.488145e-03  4.702221e-03
## ASV3137      6.596103e-04  6.826547e-04  7.065838e-04  7.314637e-04
## ASV0001      5.510228e-03  5.658968e-03  5.809249e-03  5.960996e-03
## ASV1651      3.897333e-03  4.020839e-03  4.147662e-03  4.277928e-03
## ASV1692      6.564334e-03  6.852915e-03  7.152757e-03  7.464192e-03
## ASV0660      1.395915e-03  1.386267e-03  1.372173e-03  1.353309e-03
## ASV0508      1.361198e-05  6.854202e-06 -4.260242e-07 -8.265165e-06
## ASV1660     -2.836864e-03 -2.958689e-03 -3.084661e-03 -3.214829e-03
## ASV0233      1.868412e-03  1.965786e-03  2.068098e-03  2.175571e-03
## ASV1343     -5.736512e-03 -5.969546e-03 -6.211017e-03 -6.461174e-03
## ASV0209      3.582472e-03  3.681281e-03  3.781533e-03  3.883217e-03
## ASV0193     -5.259528e-03 -5.426584e-03 -5.597470e-03 -5.772240e-03
## ASV0357      1.121737e-03  1.221848e-03  1.329023e-03  1.443643e-03
## ASV0198      1.597790e-03  1.670332e-03  1.746208e-03  1.825566e-03
## ASV0007      5.232043e-03  5.373621e-03  5.516689e-03  5.661178e-03
## ASV1772     -3.622703e-04 -3.529901e-04 -3.410775e-04 -3.262505e-04
## ASV0009      4.844626e-03  4.972443e-03  5.101416e-03  5.231479e-03
## ASV0006      8.957371e-04  8.777008e-04  8.566783e-04  8.325589e-04
## ASV0011     -8.254485e-03 -8.592513e-03 -8.942525e-03 -9.304816e-03
## ASV0015      4.915729e-03  5.087199e-03  5.262796e-03  5.442500e-03
## ASV0017      5.178670e-03  5.360539e-03  5.547004e-03  5.738071e-03
## ASV0235     -4.634073e-03 -4.815794e-03 -5.003522e-03 -5.197406e-03
## ASV0382      2.085620e-03  2.186514e-03  2.290212e-03  2.396596e-03
## ASV2357      7.035618e-03  7.321024e-03  7.616847e-03  7.923393e-03
## ASV0567     -4.485904e-03 -4.658644e-03 -4.837852e-03 -5.023781e-03
## ASV0165      5.099468e-03  5.287113e-03  5.480343e-03  5.679265e-03
## ASV0005      8.995460e-03  9.275785e-03  9.560951e-03  9.850841e-03
## ASV0384      8.818907e-04  9.722591e-04  1.069676e-03  1.174577e-03
## ASV0002      3.169481e-03  3.320639e-03  3.478299e-03  3.642654e-03
## ASV3017      5.022552e-03  5.178999e-03  5.338738e-03  5.501792e-03
## ASV0091      2.763936e-03  2.877272e-03  2.994244e-03  3.114874e-03
## ASV0186     -6.487890e-03 -6.726060e-03 -6.970364e-03 -7.220774e-03
## ASV0370      1.003172e-03  1.057454e-03  1.114813e-03  1.175416e-03
## ASV0018      9.627029e-03  9.938300e-03  1.025585e-02  1.057963e-02
## ASV1377      8.418582e-03  8.699784e-03  8.987785e-03  9.282642e-03
## ASV0019      9.687790e-03  1.000331e-02  1.032541e-02  1.065402e-02
## ASV0023     -8.818876e-04 -9.611233e-04 -1.044776e-03 -1.132948e-03
## ASV2194      4.327156e-03  4.517597e-03  4.715656e-03  4.921566e-03
## ASV1155      4.722327e-04  5.166139e-04  5.635872e-04  6.132308e-04
## ASV0510     -2.121014e-03 -2.150319e-03 -2.178537e-03 -2.205630e-03
## ASV2371     -2.796593e-03 -2.871153e-03 -2.946485e-03 -3.022542e-03
## ASV0024     -1.416303e-03 -1.516041e-03 -1.620868e-03 -1.730907e-03
## ASV2452      3.677281e-03  3.767027e-03  3.857011e-03  3.947163e-03
## ASV2332      1.630900e-03  1.726190e-03  1.825849e-03  1.929990e-03
## ASV2591      1.518877e-03  1.603997e-03  1.692667e-03  1.784950e-03
## ASV0521      8.458779e-03  8.824996e-03  9.205437e-03  9.600532e-03
## ASV5542      2.772537e-03  2.889681e-03  3.010965e-03  3.136483e-03
## ASV0336     -3.149763e-03 -3.266765e-03 -3.387729e-03 -3.512810e-03
## ASV10102     5.283777e-03  5.487804e-03  5.697886e-03  5.914075e-03
## ASV16823    -2.595017e-03 -2.663771e-03 -2.733483e-03 -2.804147e-03
## ASV3104      2.594937e-03  2.663679e-03  2.733379e-03  2.804029e-03
## ASV0781      1.590982e-03  1.644486e-03  1.699605e-03  1.756407e-03
## ASV10899     3.234655e-03  3.399349e-03  3.571466e-03  3.751251e-03
## ASV11222    -2.594836e-03 -2.663564e-03 -2.733248e-03 -2.803882e-03
## ASV11327    -2.594755e-03 -2.663473e-03 -2.733145e-03 -2.803766e-03
## ASV12458    -2.594675e-03 -2.663383e-03 -2.733044e-03 -2.803653e-03
## ASV1636     -1.998856e-03 -2.047770e-03 -2.097288e-03 -2.147423e-03
## ASV1890     -2.995820e-03 -3.096787e-03 -3.201029e-03 -3.308683e-03
## ASV2898      7.102538e-03  7.334160e-03  7.571229e-03  7.813818e-03
## ASV8328      1.080548e-03  1.171000e-03  1.266908e-03  1.368493e-03
## ASV0709     -5.893769e-03 -6.085282e-03 -6.281007e-03 -6.480957e-03
## ASV0856      1.688676e-03  1.769313e-03  1.853259e-03  1.940598e-03
## ASV0909     -6.939651e-04 -6.591431e-04 -6.203538e-04 -5.774309e-04
## ASV0937     -5.872746e-03 -6.125046e-03 -6.387660e-03 -6.660959e-03
## ASV11390    -2.594442e-03 -2.663121e-03 -2.732751e-03 -2.803325e-03
## ASV11966     2.859909e-03  2.990189e-03  3.125464e-03  3.265850e-03
## ASV12990     1.049976e-03  1.087226e-03  1.125535e-03  1.164929e-03
## ASV14797     3.046921e-03  3.136393e-03  3.227643e-03  3.320701e-03
## ASV14904    -2.594315e-03 -2.662977e-03 -2.732589e-03 -2.803145e-03
## ASV15304     2.087867e-03  2.192420e-03  2.301303e-03  2.414622e-03
## ASV16696    -2.594227e-03 -2.662880e-03 -2.732482e-03 -2.803027e-03
## ASV1690      2.999349e-03  3.129388e-03  3.263553e-03  3.401862e-03
## ASV2029      9.762938e-03  1.010508e-02  1.045650e-02  1.081733e-02
## ASV2834      5.887940e-03  6.116146e-03  6.351668e-03  6.594638e-03
## ASV4003      3.397334e-03  3.583143e-03  3.778420e-03  3.983586e-03
## ASV4064      4.420333e-03  4.594871e-03  4.775060e-03  4.961017e-03
## ASV4294      2.712475e-03  2.857150e-03  3.008838e-03  3.167808e-03
## ASV4609      1.940523e-04  2.109998e-04  2.290318e-04  2.481977e-04
## ASV6283     -2.594063e-03 -2.662698e-03 -2.732282e-03 -2.802808e-03
## ASV6491     -2.594013e-03 -2.662645e-03 -2.732224e-03 -2.802745e-03
## ASV7453      2.777960e-03  2.915533e-03  3.058810e-03  3.207929e-03
## ASV7959      1.541737e-03  1.633613e-03  1.730085e-03  1.831320e-03
## ASV8219      2.593939e-03  2.662564e-03  2.732138e-03  2.802653e-03
## ASV8547     -2.593904e-03 -2.662527e-03 -2.732099e-03 -2.802612e-03
## ASV9319      3.174144e-03  3.314365e-03  3.460473e-03  3.612698e-03
## ASV9382     -2.593866e-03 -2.662486e-03 -2.732056e-03 -2.802567e-03
## ASV11516    -2.593843e-03 -2.662463e-03 -2.732032e-03 -2.802544e-03
## ASV14377    -2.593826e-03 -2.662446e-03 -2.732015e-03 -2.802528e-03
## ASV1867      6.174457e-03  6.421523e-03  6.677051e-03  6.941259e-03
## ASV1895     -8.816357e-04 -9.102715e-04 -9.400276e-04 -9.709681e-04
## ASV3168      1.699172e-03  1.737198e-03  1.774966e-03  1.812421e-03
## ASV4449      3.858562e-03  3.986780e-03  4.118635e-03  4.254230e-03
## ASV6596      4.320987e-03  4.536077e-03  4.761008e-03  4.996136e-03
## ASV7492      5.362341e-05  9.350853e-05  1.363185e-04  1.821531e-04
## ASV9854     -1.169430e-03 -1.195798e-03 -1.222271e-03 -1.248830e-03
## ASV6296      2.593792e-03  2.662417e-03  2.731992e-03  2.802514e-03
## ASV4201      3.195262e-03  3.373822e-03  3.561208e-03  3.757756e-03
## ASV0552      1.048411e-02  1.090158e-02  1.133226e-02  1.177631e-02
## ASV3671      1.232908e-04  1.436592e-04  1.648018e-04  1.866805e-04
## ASV3529      4.258811e-04  4.674336e-04  5.109122e-04  5.563224e-04
## ASV1060      3.037994e-03  3.184238e-03  3.337647e-03  3.498564e-03
## ASV0239     -3.488657e-03 -3.565483e-03 -3.641930e-03 -3.717888e-03
## ASV5711     -3.873846e-03 -3.995483e-03 -4.119889e-03 -4.247092e-03
## ASV4152     -5.853918e-03 -6.056170e-03 -6.263593e-03 -6.476218e-03
## ASV1461      4.052732e-03  4.156589e-03  4.261541e-03  4.367572e-03
## ASV2877      4.048574e-03  4.173849e-03  4.301130e-03  4.430334e-03
## ASV0012      4.602122e-03  4.808652e-03  5.023330e-03  5.246365e-03
## ASV9823      5.753366e-04  5.751020e-04  5.738505e-04  5.715529e-04
## ASV0008      4.834207e-03  5.048029e-03  5.270239e-03  5.501062e-03
## ASV7832     -3.477638e-03 -3.598373e-03 -3.722497e-03 -3.850070e-03
## ASV1915      7.342012e-04  7.643185e-04  7.948773e-04  8.258163e-04
## ASV0055      2.505459e-03  2.585626e-03  2.666924e-03  2.749246e-03
## ASV0032      5.482175e-03  5.656114e-03  5.834196e-03  6.016520e-03
## ASV2977     -4.879828e-03 -5.045509e-03 -5.215170e-03 -5.388810e-03
## ASV0466      4.129269e-03  4.241243e-03  4.354230e-03  4.468127e-03
## ASV3866      6.442299e-03  6.709825e-03  6.987771e-03  7.276527e-03
## ASV0040      9.069137e-03  9.449955e-03  9.844555e-03  1.025326e-02
## ASV0496     -1.860521e-03 -1.973840e-03 -2.092904e-03 -2.217906e-03
## ASV0052      8.471783e-03  8.752836e-03  9.040187e-03  9.333836e-03
## ASV3828     -5.328786e-03 -5.526827e-03 -5.731651e-03 -5.943491e-03
## ASV1930      3.380503e-03  3.491407e-03  3.604520e-03  3.719823e-03
## ASV2126      5.487413e-03  5.677861e-03  5.873195e-03  6.073453e-03
## ASV0793      5.020544e-03  5.250558e-03  5.489694e-03  5.738207e-03
## ASV0299     -1.308108e-03 -1.338317e-03 -1.369709e-03 -1.402439e-03
## ASV0208      6.990192e-03  7.307244e-03  7.637715e-03  7.982085e-03
## ASV0511     -1.113505e-03 -1.105523e-03 -1.095400e-03 -1.083094e-03
## ASV1123     -2.524808e-03 -2.580583e-03 -2.636165e-03 -2.691469e-03
## ASV0099     -1.310154e-03 -1.315147e-03 -1.316676e-03 -1.314411e-03
## ASV0752     -9.754332e-04 -1.023455e-03 -1.073389e-03 -1.125284e-03
## ASV0883      4.310693e-04  4.563235e-04  4.827221e-04  5.102931e-04
## ASV0683      5.948418e-03  6.203000e-03  6.467063e-03  6.740839e-03
## ASV4117     -5.378930e-03 -5.574958e-03 -5.777091e-03 -5.985472e-03
## ASV2172      2.265384e-03  2.354171e-03  2.446039e-03  2.541075e-03
## ASV0330     -4.103405e-03 -4.259867e-03 -4.421305e-03 -4.587838e-03
## ASV0728      4.520478e-03  4.708311e-03  4.902792e-03  5.104093e-03
## ASV0499      9.257913e-03  9.670552e-03  1.009993e-02  1.054658e-02
## ASV0120     -7.767836e-03 -8.033416e-03 -8.305063e-03 -8.582746e-03
## ASV1446     -4.835694e-04 -5.427584e-04 -6.066137e-04 -6.754240e-04
## ASV17171    -5.300496e-03 -5.501792e-03 -5.709971e-03 -5.925236e-03
## ASV0533      2.178825e-03  2.281803e-03  2.389230e-03  2.501247e-03
## ASV2495     -2.954936e-03 -3.095188e-03 -3.241593e-03 -3.394347e-03
## ASV5582      1.002073e-03  1.012842e-03  1.022655e-03  1.031445e-03
## ASV1488      2.183724e-03  2.273133e-03  2.365338e-03  2.460358e-03
## ASV0682      6.332986e-03  6.608308e-03  6.894129e-03  7.190718e-03
## ASV0068     -1.276096e-03 -1.344655e-03 -1.415629e-03 -1.488988e-03
## ASV1987     -4.199726e-03 -4.402880e-03 -4.615065e-03 -4.836607e-03
## ASV0035     -1.408304e-03 -1.555801e-03 -1.714491e-03 -1.885012e-03
## ASV7192     -2.640420e-03 -2.705369e-03 -2.770318e-03 -2.835166e-03
## ASV0873     -1.814186e-04 -2.021273e-04 -2.237252e-04 -2.461997e-04
## ASV4749     -1.561872e-03 -1.680902e-03 -1.806987e-03 -1.940416e-03
## ASV2174      2.399820e-03  2.466784e-03  2.535608e-03  2.606432e-03
## ASV1476     -3.465395e-03 -3.613201e-03 -3.766691e-03 -3.926022e-03
## ASV0740     -8.979401e-03 -9.363418e-03 -9.761902e-03 -1.017524e-02
## ASV0170      1.674258e-03  1.741588e-03  1.811371e-03  1.883681e-03
## ASV2466     -6.995879e-03 -7.275630e-03 -7.565648e-03 -7.866256e-03
## ASV1709      4.855365e-03  5.024461e-03  5.197941e-03  5.375836e-03
## ASV6170     -5.290253e-03 -5.500347e-03 -5.717407e-03 -5.941570e-03
## ASV3673      6.127149e-03  6.372963e-03  6.627091e-03  6.889709e-03
## ASV1745      4.551835e-04  4.706883e-04  4.863824e-04  5.022335e-04
##                                                                    
## (Intercept) -5.153001e-03 -5.553503e-03 -5.978256e-03 -6.428196e-03
## ASV1236      3.525345e-03  3.626272e-03  3.728983e-03  3.833485e-03
## ASV0421     -6.479934e-03 -6.668305e-03 -6.860118e-03 -7.055394e-03
## ASV0691     -4.642608e-03 -4.757782e-03 -4.874573e-03 -4.993000e-03
## ASV0899      4.054494e-04  4.204409e-04  4.353139e-04  4.500323e-04
## ASV1004      7.283059e-03  7.486142e-03  7.692008e-03  7.900598e-03
## ASV1041     -4.782251e-03 -4.905172e-03 -5.028940e-03 -5.153476e-03
## ASV1058      7.052673e-03  7.267160e-03  7.486135e-03  7.709639e-03
## ASV12542     1.640275e-03  1.679273e-03  1.718882e-03  1.759127e-03
## ASV1294      8.742020e-03  9.020597e-03  9.305390e-03  9.596451e-03
## ASV13113     4.870613e-03  5.092587e-03  5.323916e-03  5.564921e-03
## ASV1318      7.055867e-03  7.262786e-03  7.473365e-03  7.687600e-03
## ASV2269     -2.059291e-03 -2.116206e-03 -2.173843e-03 -2.232187e-03
## ASV2542      6.659719e-03  6.933579e-03  7.217155e-03  7.510681e-03
## ASV2660     -3.661517e-03 -3.758441e-03 -3.856705e-03 -3.956310e-03
## ASV2737     -5.144750e-04 -5.338222e-04 -5.534617e-04 -5.733763e-04
## ASV2840      4.487973e-03  4.589186e-03  4.690570e-03  4.792060e-03
## ASV3053      2.417298e-04  2.514440e-04  2.617167e-04  2.725765e-04
## ASV3077      1.649469e-03  1.701047e-03  1.753964e-03  1.808251e-03
## ASV3134      9.425639e-03  9.846212e-03  1.028410e-02  1.073989e-02
## ASV3140      3.441229e-03  3.568056e-03  3.698392e-03  3.832270e-03
## ASV3579      2.602642e-03  2.735301e-03  2.873500e-03  3.017343e-03
## ASV6119     -2.058215e-03 -2.115143e-03 -2.172816e-03 -2.231223e-03
## ASV7557     -2.058135e-03 -2.115076e-03 -2.172767e-03 -2.231194e-03
## ASV8422      9.864782e-04  1.014917e-03  1.044087e-03  1.074009e-03
## ASV1086     -5.244481e-04 -5.421994e-04 -5.606350e-04 -5.797830e-04
## ASV1310      4.194834e-03  4.314560e-03  4.435422e-03  4.557286e-03
## ASV15750    -7.665571e-04 -7.793557e-04 -7.917492e-04 -8.037044e-04
## ASV16905    -2.058211e-03 -2.115232e-03 -2.173019e-03 -2.231559e-03
## ASV2033      5.903240e-03  6.139865e-03  6.384069e-03  6.635976e-03
## ASV2089      1.423694e-03  1.462268e-03  1.501240e-03  1.540592e-03
## ASV2127      5.988354e-03  6.172352e-03  6.360002e-03  6.551297e-03
## ASV2725      5.747133e-03  5.893422e-03  6.041235e-03  6.190537e-03
## ASV2804     -2.058416e-03 -2.115504e-03 -2.173367e-03 -2.231991e-03
## ASV3075      5.162869e-03  5.366420e-03  5.577595e-03  5.796649e-03
## ASV3327      5.638996e-03  5.867761e-03  6.104368e-03  6.348995e-03
## ASV3342      5.531589e-03  5.739891e-03  5.954606e-03  6.175855e-03
## ASV3532     -5.128133e-03 -5.334750e-03 -5.549229e-03 -5.771866e-03
## ASV3600      6.206451e-03  6.438477e-03  6.677504e-03  6.923646e-03
## ASV4013      4.311579e-03  4.442929e-03  4.576461e-03  4.712115e-03
## ASV4136      3.919010e-03  4.036962e-03  4.157514e-03  4.280708e-03
## ASV4195      2.058796e-03  2.115970e-03  2.173927e-03  2.232655e-03
## ASV4407     -2.058912e-03 -2.116108e-03 -2.174089e-03 -2.232841e-03
## ASV4717     -1.373078e-04 -1.438718e-04 -1.504076e-04 -1.568897e-04
## ASV6794      1.904450e-03  1.962458e-03  2.022155e-03  2.083601e-03
## ASV8324     -2.059305e-03 -2.116567e-03 -2.174620e-03 -2.233448e-03
## ASV8981      2.224805e-04  2.590040e-04  2.979924e-04  3.395259e-04
## ASV9859      3.613958e-03  3.805591e-03  4.006882e-03  4.218250e-03
## ASV0936     -3.559368e-03 -3.673239e-03 -3.789680e-03 -3.908715e-03
## ASV12683    -5.587829e-04 -5.777282e-04 -5.969164e-04 -6.163247e-04
## ASV1293      4.775406e-03  4.914701e-03  5.056583e-03  5.201065e-03
## ASV13055    -2.136710e-04 -2.081237e-04 -2.017240e-04 -1.944262e-04
## ASV17063    -2.060032e-03 -2.117381e-03 -2.175520e-03 -2.234433e-03
## ASV2228      2.060152e-03  2.117513e-03  2.175663e-03  2.234585e-03
## ASV2769      1.508483e-04  1.684963e-04  1.867406e-04  2.055473e-04
## ASV2803      7.518263e-04  7.709029e-04  7.904269e-04  8.104256e-04
## ASV2896      3.927715e-03  4.109076e-03  4.299161e-03  4.498402e-03
## ASV3062      2.057833e-03  2.162973e-03  2.272549e-03  2.386661e-03
## ASV3107      4.222492e-03  4.386552e-03  4.556042e-03  4.731081e-03
## ASV3265      6.089971e-03  6.260451e-03  6.433409e-03  6.608796e-03
## ASV3666     -3.517472e-04 -3.710257e-04 -3.912566e-04 -4.124667e-04
## ASV4497      1.520007e-03  1.566169e-03  1.613301e-03  1.661421e-03
## ASV6914     -9.353618e-04 -9.683151e-04 -1.002133e-03 -1.036821e-03
## ASV0576     -6.396564e-03 -6.564371e-03 -6.734861e-03 -6.908067e-03
## ASV0673      2.904002e-03  3.009697e-03  3.117814e-03  3.228339e-03
## ASV0772      2.773075e-03  2.876397e-03  2.983072e-03  3.093189e-03
## ASV0862     -1.058417e-03 -1.067193e-03 -1.075204e-03 -1.082453e-03
## ASV0898      3.083987e-03  3.209941e-03  3.339805e-03  3.473625e-03
## ASV0910      6.387371e-03  6.655524e-03  6.933205e-03  7.220643e-03
## ASV0964     -2.328382e-03 -2.384261e-03 -2.440507e-03 -2.497104e-03
## ASV10059     3.334744e-03  3.488885e-03  3.649515e-03  3.816859e-03
## ASV10263    -2.061601e-03 -2.119104e-03 -2.177399e-03 -2.236466e-03
## ASV1088      3.827498e-03  4.008747e-03  4.197916e-03  4.395277e-03
## ASV1101      3.762622e-03  3.861791e-03  3.961113e-03  4.060433e-03
## ASV1183      2.891842e-03  2.995324e-03  3.101760e-03  3.211200e-03
## ASV11956     5.661468e-04  5.781621e-04  5.904940e-04  6.031743e-04
## ASV12774    -5.820822e-04 -6.071055e-04 -6.329946e-04 -6.597635e-04
## ASV1321      2.434315e-03  2.556959e-03  2.684606e-03  2.817357e-03
## ASV13793    -2.061994e-03 -2.119522e-03 -2.177840e-03 -2.236930e-03
## ASV14482    -3.522433e-04 -3.626283e-04 -3.729565e-04 -3.832000e-04
## ASV15483     2.071032e-03  2.152674e-03  2.237022e-03  2.324144e-03
## ASV2062      1.072977e-02  1.109125e-02  1.146154e-02  1.184069e-02
## ASV2132      5.916058e-03  6.149119e-03  6.389736e-03  6.638046e-03
## ASV2413      6.300837e-03  6.501972e-03  6.707918e-03  6.918746e-03
## ASV2490      3.500495e-03  3.590546e-03  3.681598e-03  3.773629e-03
## ASV2594      3.064081e-03  3.200461e-03  3.342961e-03  3.491841e-03
## ASV2822     -2.062431e-03 -2.120003e-03 -2.178371e-03 -2.237517e-03
## ASV2863      3.583188e-03  3.689668e-03  3.798338e-03  3.909222e-03
## ASV2910      4.558177e-03  4.689780e-03  4.823944e-03  4.960710e-03
## ASV2980      1.540377e-03  1.577153e-03  1.614037e-03  1.650997e-03
## ASV3307      2.062749e-03  2.120357e-03  2.178767e-03  2.237964e-03
## ASV3474      5.290451e-03  5.510354e-03  5.737451e-03  5.971828e-03
## ASV3502      8.336803e-03  8.640421e-03  8.953544e-03  9.276429e-03
## ASV4236      3.099035e-03  3.179992e-03  3.262047e-03  3.345206e-03
## ASV4842     -1.134460e-03 -1.163136e-03 -1.191880e-03 -1.220663e-03
## ASV4894     -2.063076e-03 -2.120729e-03 -2.179192e-03 -2.238453e-03
## ASV5290      2.963828e-03  3.057664e-03  3.153206e-03  3.250433e-03
## ASV5501      7.438837e-04  7.804238e-04  8.188200e-04  8.591554e-04
## ASV5795      2.577668e-03  2.680567e-03  2.786697e-03  2.896095e-03
## ASV5987     -2.063418e-03 -2.121122e-03 -2.179646e-03 -2.238979e-03
## ASV6267     -2.063534e-03 -2.121257e-03 -2.179803e-03 -2.239163e-03
## ASV6862      3.479557e-03  3.573259e-03  3.668705e-03  3.765928e-03
## ASV7145      7.096986e-04  7.373947e-04  7.663405e-04  7.965889e-04
## ASV7673     -2.063825e-03 -2.121595e-03 -2.180196e-03 -2.239619e-03
## ASV7789      2.207678e-03  2.328032e-03  2.454072e-03  2.585983e-03
## ASV7809      3.694614e-04  4.006187e-04  4.333267e-04  4.676069e-04
## ASV8002     -2.064229e-03 -2.122066e-03 -2.180748e-03 -2.240266e-03
## ASV8205      1.676655e-03  1.746157e-03  1.818250e-03  1.892998e-03
## ASV9155     -1.454745e-03 -1.491630e-03 -1.528805e-03 -1.566255e-03
## ASV9221      6.100481e-04  6.610509e-04  7.150960e-04  7.722988e-04
## ASV9311     -2.064917e-03 -2.122870e-03 -2.181685e-03 -2.241358e-03
## ASV9557     -2.065123e-03 -2.123111e-03 -2.181965e-03 -2.241683e-03
## ASV9936     -2.065339e-03 -2.123361e-03 -2.182255e-03 -2.242018e-03
## ASV1445      6.669262e-03  6.933352e-03  7.206505e-03  7.488948e-03
## ASV4232      6.873841e-03  7.194586e-03  7.529643e-03  7.879566e-03
## ASV6479      1.329180e-03  1.419983e-03  1.515770e-03  1.616721e-03
## ASV0142     -9.982300e-03 -1.026116e-02 -1.054451e-02 -1.083233e-02
## ASV0378     -2.444548e-03 -2.476702e-03 -2.507011e-03 -2.535362e-03
## ASV1122      8.648329e-03  8.976933e-03  9.315484e-03  9.664131e-03
## ASV0123     -9.701784e-03 -9.969449e-03 -1.024117e-02 -1.051693e-02
## ASV2064      6.517731e-04  6.616701e-04  6.715939e-04  6.815755e-04
## ASV4459     -1.057801e-03 -1.087659e-03 -1.118211e-03 -1.149490e-03
## ASV0448      3.931675e-03  4.120176e-03  4.316347e-03  4.520382e-03
## ASV0397      5.962505e-03  6.175415e-03  6.394153e-03  6.618790e-03
## ASV0485      7.912254e-03  8.195327e-03  8.486962e-03  8.787360e-03
## ASV1566      6.877355e-03  7.119115e-03  7.367310e-03  7.622019e-03
## ASV1365      4.541467e-03  4.698902e-03  4.859933e-03  5.024530e-03
## ASV1065      9.413580e-03  9.758226e-03  1.011293e-02  1.047784e-02
## ASV0722     -9.131746e-05 -9.821853e-05 -1.059351e-04 -1.145431e-04
## ASV12660    -3.174815e-03 -3.260443e-03 -3.347322e-03 -3.435451e-03
## ASV0223      1.188155e-04  1.376056e-04  1.581029e-04  1.804165e-04
## ASV0229      4.857377e-03  5.057815e-03  5.265584e-03  5.480893e-03
## ASV0877     -8.313236e-04 -8.479845e-04 -8.650168e-04 -8.824685e-04
## ASV0983      7.416359e-03  7.654466e-03  7.897957e-03  8.146861e-03
## ASV0626     -9.987364e-04 -9.972150e-04 -9.946703e-04 -9.911215e-04
## ASV4146     -4.400347e-04 -4.649429e-04 -4.919259e-04 -5.211667e-04
## ASV4175     -5.070625e-03 -5.245354e-03 -5.424403e-03 -5.607792e-03
## ASV2082     -1.576368e-03 -1.675445e-03 -1.779789e-03 -1.889588e-03
## ASV2272      4.408897e-03  4.588883e-03  4.775021e-03  4.967429e-03
## ASV2245     -4.703768e-03 -4.877612e-03 -5.056729e-03 -5.241229e-03
## ASV0590     -4.321618e-03 -4.521953e-03 -4.730226e-03 -4.946652e-03
## ASV0217     -3.743382e-04 -2.903043e-04 -1.997269e-04 -1.024044e-04
## ASV0416      2.267732e-03  2.296578e-03  2.323614e-03  2.348692e-03
## ASV1056      6.399888e-03  6.658296e-03  6.924629e-03  7.198964e-03
## ASV7777     -4.656731e-03 -4.836524e-03 -5.022801e-03 -5.215805e-03
## ASV0455      1.149679e-03  1.187305e-03  1.225122e-03  1.263043e-03
## ASV0604      2.181682e-03  2.289453e-03  2.401536e-03  2.518042e-03
## ASV6100     -4.457521e-03 -4.635350e-03 -4.819895e-03 -5.011408e-03
## ASV11359    -4.302745e-03 -4.443423e-03 -4.587105e-03 -4.733776e-03
## ASV6604      3.996503e-03  4.163467e-03  4.336450e-03  4.515594e-03
## ASV5004     -2.612113e-03 -2.707093e-03 -2.805254e-03 -2.906708e-03
## ASV1483     -2.488562e-03 -2.578130e-03 -2.670295e-03 -2.765097e-03
## ASV9773     -5.530725e-03 -5.742323e-03 -5.961162e-03 -6.187460e-03
## ASV4059      1.380655e-03  1.454742e-03  1.531961e-03  1.612366e-03
## ASV1193      8.496598e-03  8.796450e-03  9.104338e-03  9.420341e-03
## ASV4610      4.195066e-04  4.536463e-04  4.887323e-04  5.246926e-04
## ASV0742     -1.188096e-03 -1.184833e-03 -1.180103e-03 -1.173913e-03
## ASV1502     -7.260632e-04 -7.684529e-04 -8.126605e-04 -8.587162e-04
## ASV0195     -1.727444e-03 -1.808932e-03 -1.893715e-03 -1.981903e-03
## ASV1213      1.568685e-03  1.590897e-03  1.611939e-03  1.631710e-03
## ASV1648     -4.076560e-03 -4.236837e-03 -4.403188e-03 -4.575850e-03
## ASV6984     -3.309778e-03 -3.449094e-03 -3.594226e-03 -3.745421e-03
## ASV0396      6.147239e-04  7.014319e-04  7.926512e-04  8.884119e-04
## ASV4297      3.306614e-03  3.398482e-03  3.491879e-03  3.586807e-03
## ASV2622      8.282408e-03  8.537835e-03  8.799019e-03  9.066049e-03
## ASV3512      3.248022e-03  3.426860e-03  3.614879e-03  3.812477e-03
## ASV2411      4.440709e-03  4.624901e-03  4.815055e-03  5.011212e-03
## ASV2291     -1.823480e-03 -1.917504e-03 -2.015585e-03 -2.117827e-03
## ASV0807      6.027537e-03  6.290699e-03  6.563054e-03  6.844763e-03
## ASV1292      2.019330e-03  2.091837e-03  2.166929e-03  2.244713e-03
## ASV1035      7.093046e-04  7.330781e-04  7.578823e-04  7.837754e-04
## ASV0070     -2.070999e-04 -1.446550e-04 -7.649193e-05 -2.340935e-06
## ASV0255      6.148737e-04  6.095607e-04  6.013345e-04  5.899010e-04
## ASV0057     -6.661848e-03 -6.789311e-03 -6.914312e-03 -7.036534e-03
## ASV0077      2.093629e-04  2.614202e-04  3.165245e-04  3.746850e-04
## ASV0625      7.835578e-03  8.045766e-03  8.258297e-03  8.473057e-03
## ASV2464      3.548254e-03  3.641968e-03  3.737000e-03  3.833340e-03
## ASV1315      1.108431e-02  1.154047e-02  1.201211e-02  1.249952e-02
## ASV2673      8.810575e-03  9.207174e-03  9.620181e-03  1.005016e-02
## ASV2161      3.779222e-03  3.952670e-03  4.133353e-03  4.321501e-03
## ASV0337     -3.826089e-03 -3.946397e-03 -4.069184e-03 -4.194458e-03
## ASV7680     -5.395832e-03 -5.600616e-03 -5.811906e-03 -6.029831e-03
## ASV0611      1.327624e-02  1.383527e-02  1.441544e-02  1.501738e-02
## ASV3118     -4.208649e-03 -4.371983e-03 -4.540507e-03 -4.714309e-03
## ASV1284      4.485721e-03  4.660130e-03  4.839853e-03  5.024935e-03
## ASV0889      2.890581e-03  2.999193e-03  3.111763e-03  3.228451e-03
## ASV4649     -3.162828e-03 -3.277193e-03 -3.394906e-03 -3.516024e-03
## ASV1108     -5.531440e-03 -5.778009e-03 -6.034235e-03 -6.300379e-03
## ASV0738      2.649885e-03  2.845025e-03  3.051422e-03  3.269552e-03
## ASV0473      8.217390e-04  8.593457e-04  8.985327e-04  9.393562e-04
## ASV0598     -2.811183e-03 -2.864457e-03 -2.916889e-03 -2.968361e-03
## ASV0429      6.433305e-03  6.635099e-03  6.841013e-03  7.051052e-03
## ASV1549      9.874583e-03  1.030853e-02  1.075877e-02  1.122567e-02
## ASV1203      5.179613e-03  5.351055e-03  5.526221e-03  5.705080e-03
## ASV4532      1.172096e-04  1.293425e-04  1.430092e-04  1.583567e-04
## ASV0274     -3.654945e-03 -3.741308e-03 -3.828546e-03 -3.916682e-03
## ASV0163     -4.980399e-03 -5.085784e-03 -5.191160e-03 -5.296467e-03
## ASV1298      2.276692e-03  2.346291e-03  2.418316e-03  2.492919e-03
## ASV9424     -7.650619e-03 -7.960134e-03 -8.280862e-03 -8.613132e-03
## ASV0412      9.634806e-03  9.958982e-03  1.029106e-02  1.063110e-02
## ASV0284      3.213108e-03  3.286610e-03  3.359759e-03  3.432399e-03
## ASV0620     -4.608819e-03 -4.803338e-03 -5.004674e-03 -5.212974e-03
## ASV0153     -8.581900e-03 -8.920225e-03 -9.268691e-03 -9.627353e-03
## ASV0498      2.737267e-03  2.871149e-03  3.009086e-03  3.151002e-03
## ASV0097      6.881237e-03  7.186471e-03  7.503736e-03  7.833368e-03
## ASV0104     -2.293005e-02 -2.371856e-02 -2.452717e-02 -2.535604e-02
## ASV1282      4.353297e-03  4.504563e-03  4.658987e-03  4.816487e-03
## ASV3883     -2.954567e-03 -3.066216e-03 -3.180468e-03 -3.297246e-03
## ASV0801      3.559505e-03  3.722552e-03  3.892391e-03  4.069260e-03
## ASV1611     -1.030761e-02 -1.071310e-02 -1.113203e-02 -1.156466e-02
## ASV0227     -5.005826e-03 -5.233627e-03 -5.470541e-03 -5.716852e-03
## ASV0833      5.153295e-03  5.375258e-03  5.604882e-03  5.842296e-03
## ASV0718      8.818290e-03  9.136812e-03  9.463883e-03  9.799552e-03
## ASV1139      1.083008e-03  1.057906e-03  1.028661e-03  9.950699e-04
## ASV0766     -1.823148e-03 -1.876616e-03 -1.931274e-03 -1.987155e-03
## ASV2091      8.622163e-03  8.856890e-03  9.095017e-03  9.336517e-03
## ASV1238      8.383168e-04  9.075544e-04  9.801211e-04  1.056050e-03
## ASV9193     -2.351665e-03 -2.467627e-03 -2.587882e-03 -2.712462e-03
## ASV0290     -1.513560e-03 -1.564884e-03 -1.616142e-03 -1.667159e-03
## ASV0231      8.682472e-03  8.979358e-03  9.283477e-03  9.594839e-03
## ASV0185      7.060684e-03  7.491594e-03  7.945159e-03  8.422266e-03
## ASV2330      2.096651e-03  2.161153e-03  2.227347e-03  2.295298e-03
## ASV3119     -5.171204e-03 -5.425293e-03 -5.690454e-03 -5.967045e-03
## ASV2368     -5.606272e-03 -5.865355e-03 -6.135849e-03 -6.418189e-03
## ASV0122     -2.274476e-03 -2.334162e-03 -2.395017e-03 -2.457113e-03
## ASV1044      8.113620e-03  8.479098e-03  8.859003e-03  9.253745e-03
## ASV0160     -4.814049e-03 -4.903636e-03 -4.992448e-03 -5.080435e-03
## ASV0326      5.207654e-03  5.386269e-03  5.568882e-03  5.755447e-03
## ASV1388      8.944229e-03  9.262507e-03  9.589880e-03  9.926506e-03
## ASV0792      8.778781e-03  9.040281e-03  9.305987e-03  9.575807e-03
## ASV0036     -7.297914e-03 -7.566656e-03 -7.841932e-03 -8.123638e-03
## ASV2125      1.022423e-02  1.056921e-02  1.092206e-02  1.128273e-02
## ASV1075      2.756803e-03  2.878978e-03  3.005919e-03  3.137759e-03
## ASV0390      4.062350e-03  4.285054e-03  4.519268e-03  4.765496e-03
## ASV3790     -9.371109e-03 -9.731437e-03 -1.010327e-02 -1.048684e-02
## ASV1535     -1.503994e-03 -1.581882e-03 -1.662997e-03 -1.747389e-03
## ASV0263      1.893165e-03  1.965934e-03  2.041147e-03  2.118868e-03
## ASV0675      1.756683e-02  1.830302e-02  1.906549e-02  1.985482e-02
## ASV3348      2.265521e-03  2.378099e-03  2.495775e-03  2.618734e-03
## ASV0058     -1.223587e-02 -1.262449e-02 -1.302058e-02 -1.342404e-02
## ASV4142      2.878798e-03  2.967457e-03  3.058119e-03  3.150827e-03
## ASV0059     -1.027001e-02 -1.058460e-02 -1.090440e-02 -1.122924e-02
## ASV0013     -2.341108e-02 -2.422510e-02 -2.506070e-02 -2.591814e-02
## ASV0033     -8.238580e-03 -8.556261e-03 -8.882996e-03 -9.218803e-03
## ASV4354     -2.685547e-03 -2.777353e-03 -2.871803e-03 -2.968938e-03
## ASV0022     -8.470701e-03 -8.787191e-03 -9.111799e-03 -9.444441e-03
## ASV0134     -2.879097e-03 -3.017372e-03 -3.162140e-03 -3.313716e-03
## ASV0415      6.852439e-05  1.090482e-04  1.521555e-04  1.979093e-04
## ASV10103    -5.716482e-03 -5.932166e-03 -6.154195e-03 -6.382637e-03
## ASV1613      7.039554e-03  7.239818e-03  7.442437e-03  7.647270e-03
## ASV0135      2.304454e-03  2.478528e-03  2.662956e-03  2.858182e-03
## ASV0469     -9.053466e-03 -9.342067e-03 -9.637606e-03 -9.940195e-03
## ASV0471      7.064409e-03  7.334161e-03  7.613189e-03  7.901798e-03
## ASV0451     -2.985763e-03 -3.123924e-03 -3.267297e-03 -3.415978e-03
## ASV0747      3.784310e-03  3.945119e-03  4.111032e-03  4.282077e-03
## ASV1314     -6.210432e-03 -6.517375e-03 -6.838754e-03 -7.175149e-03
## ASV0425     -8.697081e-03 -8.917781e-03 -9.140658e-03 -9.365655e-03
## ASV0559     -5.597901e-03 -5.789927e-03 -5.988762e-03 -6.194715e-03
## ASV0148     -4.760390e-03 -4.845651e-03 -4.928422e-03 -5.008429e-03
## ASV0129     -7.785354e-04 -7.155618e-04 -6.459109e-04 -5.692853e-04
## ASV1072      2.063894e-03  2.092437e-03  2.119697e-03  2.145623e-03
## ASV2390      1.365302e-03  1.374906e-03  1.382681e-03  1.388531e-03
## ASV0548      8.347307e-03  8.663282e-03  8.988994e-03  9.324621e-03
## ASV0168     -1.040328e-02 -1.074798e-02 -1.110169e-02 -1.146460e-02
## ASV0066     -7.773737e-03 -8.015617e-03 -8.261573e-03 -8.511464e-03
## ASV0468     -3.384446e-03 -3.519377e-03 -3.659584e-03 -3.805294e-03
## ASV0172      7.943655e-04  8.998153e-04  1.012178e-03  1.131707e-03
## ASV0236     -9.864252e-04 -9.233195e-04 -8.539012e-04 -7.779648e-04
## ASV0250      4.599509e-03  4.906497e-03  5.230416e-03  5.571933e-03
## ASV0338      1.031598e-03  1.102046e-03  1.175353e-03  1.251537e-03
## ASV0450     -7.607068e-05 -8.631022e-05 -9.786264e-05 -1.108576e-04
## ASV0377      9.323766e-03  9.643697e-03  9.971048e-03  1.030576e-02
## ASV1022      3.047518e-03  3.176092e-03  3.309819e-03  3.448886e-03
## ASV6174     -6.225243e-04 -6.469950e-04 -6.721883e-04 -6.980764e-04
## ASV0786      5.713701e-04  5.805944e-04  5.896783e-04  5.986180e-04
## ASV0053     -1.153584e-02 -1.194645e-02 -1.236806e-02 -1.280078e-02
## ASV0697     -1.990875e-03 -2.026696e-03 -2.061964e-03 -2.096647e-03
## ASV0785      8.552616e-03  8.863952e-03  9.184929e-03  9.515823e-03
## ASV1967     -4.303427e-03 -4.427070e-03 -4.552950e-03 -4.681068e-03
## ASV0385     -1.452044e-03 -1.476131e-03 -1.499985e-03 -1.523615e-03
## ASV0295      2.448428e-03  2.617573e-03  2.796264e-03  2.984874e-03
## ASV0072     -6.467169e-03 -6.609560e-03 -6.750759e-03 -6.890508e-03
## ASV0157     -1.221581e-03 -1.166168e-03 -1.102328e-03 -1.029490e-03
## ASV0501      5.764911e-03  6.016180e-03  6.276442e-03  6.545858e-03
## ASV10729    -7.477026e-03 -7.754990e-03 -8.040920e-03 -8.334903e-03
## ASV1470      2.537147e-03  2.600221e-03  2.663241e-03  2.726090e-03
## ASV0050     -2.077807e-02 -2.145271e-02 -2.214218e-02 -2.284648e-02
## ASV0411      4.285021e-04  4.700400e-04  5.134312e-04  5.586239e-04
## ASV0549      5.901171e-03  6.165183e-03  6.439749e-03  6.725182e-03
## ASV0184      2.936158e-03  3.057956e-03  3.184497e-03  3.315929e-03
## ASV0705      3.581002e-03  3.708981e-03  3.839784e-03  3.973351e-03
## ASV1715      8.576898e-03  8.899714e-03  9.232513e-03  9.575485e-03
## ASV0603      1.633977e-03  1.725158e-03  1.821513e-03  1.923301e-03
## ASV0826      1.881094e-03  1.924763e-03  1.968482e-03  2.012204e-03
## ASV0034     -8.278737e-03 -8.503133e-03 -8.729505e-03 -8.957675e-03
## ASV0838      1.569340e-03  1.593169e-03  1.614952e-03  1.634454e-03
## ASV0614     -5.070398e-03 -5.223319e-03 -5.378621e-03 -5.536219e-03
## ASV0014     -2.052722e-02 -2.121110e-02 -2.191139e-02 -2.262820e-02
## ASV0585     -1.476147e-03 -1.524541e-03 -1.573498e-03 -1.622940e-03
## ASV0016     -2.113673e-02 -2.184605e-02 -2.257270e-02 -2.331682e-02
## ASV5394     -5.934001e-03 -6.141401e-03 -6.353292e-03 -6.569548e-03
## ASV0666      4.425443e-03  4.567173e-03  4.711871e-03  4.859535e-03
## ASV2085     -2.482583e-04 -3.128485e-04 -3.817489e-04 -4.551076e-04
## ASV0003     -1.890960e-02 -1.953266e-02 -2.017050e-02 -2.082325e-02
## ASV0346      1.824939e-03  1.945953e-03  2.072608e-03  2.205026e-03
## ASV0267     -1.670715e-03 -1.688187e-03 -1.704762e-03 -1.720478e-03
## ASV0353      7.049630e-03  7.382393e-03  7.728747e-03  8.089053e-03
## ASV2419      5.155682e-03  5.321285e-03  5.490445e-03  5.663138e-03
## ASV0447      5.226873e-03  5.477345e-03  5.737713e-03  6.008224e-03
## ASV0654      9.727803e-03  1.007780e-02  1.043660e-02  1.080421e-02
## ASV0151      3.548312e-03  3.750377e-03  3.962662e-03  4.185549e-03
## ASV0065     -7.624794e-03 -7.866501e-03 -8.112810e-03 -8.363666e-03
## ASV0527      5.767553e-03  5.962377e-03  6.161799e-03  6.365825e-03
## ASV4055     -3.432662e-03 -3.606950e-03 -3.790241e-03 -3.982993e-03
## ASV0166     -5.327627e-03 -5.473350e-03 -5.621118e-03 -5.770916e-03
## ASV0417     -5.255405e-03 -5.429753e-03 -5.608613e-03 -5.792069e-03
## ASV0078     -3.017396e-03 -3.057894e-03 -3.094863e-03 -3.127967e-03
## ASV0322     -3.974343e-03 -4.058893e-03 -4.142708e-03 -4.225666e-03
## ASV0156     -6.464258e-03 -6.673340e-03 -6.887666e-03 -7.107349e-03
## ASV0648     -7.713497e-03 -8.018812e-03 -8.334217e-03 -8.659918e-03
## ASV0407      1.309411e-03  1.382033e-03  1.458215e-03  1.538090e-03
## ASV2030     -1.035417e-03 -1.078302e-03 -1.123705e-03 -1.171794e-03
## ASV0300      5.828171e-03  6.085438e-03  6.351796e-03  6.627373e-03
## ASV1150      3.128301e-04  3.497226e-04  3.888869e-04  4.303739e-04
## ASV0958      6.751748e-03  7.093934e-03  7.452571e-03  7.828325e-03
## ASV0216     -5.680098e-03 -5.865520e-03 -6.056934e-03 -6.254617e-03
## ASV0446      1.242749e-02  1.293662e-02  1.346256e-02  1.400560e-02
## ASV0367     -3.239615e-03 -3.354200e-03 -3.472154e-03 -3.593555e-03
## ASV0200     -6.552161e-03 -6.798740e-03 -7.053109e-03 -7.315433e-03
## ASV0334     -6.195089e-04 -5.805739e-04 -5.385042e-04 -4.932686e-04
## ASV1311      3.823866e-03  3.938167e-03  4.054174e-03  4.171811e-03
## ASV0458      4.679734e-03  4.848125e-03  5.021422e-03  5.199707e-03
## ASV1371      2.429754e-04  2.528786e-04  2.629709e-04  2.732360e-04
## ASV0418      6.151369e-03  6.387867e-03  6.632365e-03  6.885078e-03
## ASV0004      6.716329e-03  6.946547e-03  7.182410e-03  7.423933e-03
## ASV1943      4.481490e-03  4.628956e-03  4.779963e-03  4.934538e-03
## ASV1495     -3.085526e-03 -3.257715e-03 -3.438474e-03 -3.628126e-03
## ASV0901     -9.708537e-03 -1.011953e-02 -1.054613e-02 -1.098880e-02
## ASV0628      3.395432e-03  3.466050e-03  3.534847e-03  3.601520e-03
## ASV0400      1.317601e-03  1.338969e-03  1.358694e-03  1.376553e-03
## ASV0116     -8.168598e-03 -8.526500e-03 -8.898082e-03 -9.283700e-03
## ASV0788      5.193288e-03  5.381456e-03  5.574828e-03  5.773465e-03
## ASV0117      4.925572e-03  5.158503e-03  5.401320e-03  5.654333e-03
## ASV3137      7.573680e-04  7.843783e-04  8.125850e-04  8.420880e-04
## ASV0001      6.114138e-03  6.268603e-03  6.424322e-03  6.581228e-03
## ASV1651      4.411775e-03  4.549350e-03  4.690814e-03  4.836341e-03
## ASV1692      7.787554e-03  8.123182e-03  8.471420e-03  8.832616e-03
## ASV0660      1.329339e-03  1.299918e-03  1.264692e-03  1.223298e-03
## ASV0508     -1.670423e-05 -2.578932e-05 -3.557225e-05 -4.611118e-05
## ASV1660     -3.349236e-03 -3.487917e-03 -3.630899e-03 -3.778200e-03
## ASV0233      2.288435e-03  2.406926e-03  2.531292e-03  2.661784e-03
## ASV1343     -6.720270e-03 -6.988564e-03 -7.266317e-03 -7.553799e-03
## ASV0209      3.986317e-03  4.090820e-03  4.196711e-03  4.303976e-03
## ASV0193     -5.950947e-03 -6.133646e-03 -6.320396e-03 -6.511253e-03
## ASV0357      1.566107e-03  1.696824e-03  1.836217e-03  1.984723e-03
## ASV0198      1.908555e-03  1.995329e-03  2.086044e-03  2.180861e-03
## ASV0007      5.807019e-03  5.954146e-03  6.102494e-03  6.252000e-03
## ASV1772     -3.082054e-04 -2.866157e-04 -2.611313e-04 -2.313772e-04
## ASV0009      5.362568e-03  5.494621e-03  5.627580e-03  5.761388e-03
## ASV0006      8.052370e-04  7.746120e-04  7.405891e-04  7.030800e-04
## ASV0011     -9.679681e-03 -1.006741e-02 -1.046830e-02 -1.088262e-02
## ASV0015      5.626283e-03  5.814109e-03  6.005931e-03  6.201690e-03
## ASV0017      5.933739e-03  6.133999e-03  6.338831e-03  6.548209e-03
## ASV0235     -5.397598e-03 -5.604255e-03 -5.817539e-03 -6.037615e-03
## ASV0382      2.505522e-03  2.616827e-03  2.730325e-03  2.845806e-03
## ASV2357      8.240972e-03  8.569895e-03  8.910471e-03  9.263012e-03
## ASV0567     -5.216691e-03 -5.416850e-03 -5.624533e-03 -5.840019e-03
## ASV0165      5.883990e-03  6.094626e-03  6.311286e-03  6.534083e-03
## ASV0005      1.014533e-02  1.044427e-02  1.074752e-02  1.105493e-02
## ASV0384      1.287421e-03  1.408683e-03  1.538860e-03  1.678468e-03
## ASV0002      3.813897e-03  3.992218e-03  4.177801e-03  4.370829e-03
## ASV3017      5.668182e-03  5.837929e-03  6.011055e-03  6.187582e-03
## ASV0091      3.239173e-03  3.367145e-03  3.498780e-03  3.634057e-03
## ASV0186     -7.477249e-03 -7.739731e-03 -8.008149e-03 -8.282415e-03
## ASV0370      1.239442e-03  1.307071e-03  1.378494e-03  1.453906e-03
## ASV0018      1.090956e-02  1.124557e-02  1.158758e-02  1.193550e-02
## ASV1377      9.584413e-03  9.893152e-03  1.020891e-02  1.053175e-02
## ASV0019      1.098912e-02  1.133063e-02  1.167851e-02  1.203267e-02
## ASV0023     -1.225736e-03 -1.323227e-03 -1.425501e-03 -1.532626e-03
## ASV2194      5.135561e-03  5.357877e-03  5.588749e-03  5.828412e-03
## ASV1155      6.656223e-04  7.208386e-04  7.789559e-04  8.400499e-04
## ASV0510     -2.231566e-03 -2.256315e-03 -2.279854e-03 -2.302162e-03
## ASV2371     -3.099272e-03 -3.176626e-03 -3.254547e-03 -3.332983e-03
## ASV0024     -1.846270e-03 -1.967062e-03 -2.093383e-03 -2.225319e-03
## ASV2452      4.037414e-03  4.127696e-03  4.217946e-03  4.308105e-03
## ASV2332      2.038720e-03  2.152145e-03  2.270367e-03  2.393483e-03
## ASV2591      1.880905e-03  1.980589e-03  2.084052e-03  2.191341e-03
## ASV0521      1.001072e-02  1.043644e-02  1.087815e-02  1.133629e-02
## ASV5542      3.266331e-03  3.400606e-03  3.539401e-03  3.682811e-03
## ASV0336     -3.642174e-03 -3.775996e-03 -3.914465e-03 -4.057780e-03
## ASV10102     6.136415e-03  6.364938e-03  6.599670e-03  6.840626e-03
## ASV16823    -2.875757e-03 -2.948308e-03 -3.021797e-03 -3.096218e-03
## ASV3104      2.875624e-03  2.948160e-03  3.021630e-03  3.096032e-03
## ASV0781      1.814968e-03  1.875364e-03  1.937679e-03  2.002000e-03
## ASV10899     3.938953e-03  4.134824e-03  4.339115e-03  4.552077e-03
## ASV11222    -2.875459e-03 -2.947974e-03 -3.021423e-03 -3.095802e-03
## ASV11327    -2.875329e-03 -2.947829e-03 -3.021262e-03 -3.095624e-03
## ASV12458    -2.875203e-03 -2.947689e-03 -3.021106e-03 -3.095451e-03
## ASV1636     -2.198189e-03 -2.249605e-03 -2.301690e-03 -2.354467e-03
## ASV1890     -3.419895e-03 -3.534820e-03 -3.653620e-03 -3.776465e-03
## ASV2898      8.062001e-03  8.315857e-03  8.575467e-03  8.840919e-03
## ASV8328      1.475976e-03  1.589581e-03  1.709533e-03  1.836056e-03
## ASV0709     -6.685146e-03 -6.893587e-03 -7.106290e-03 -7.323267e-03
## ASV0856      2.031413e-03  2.125786e-03  2.223795e-03  2.325516e-03
## ASV0909     -5.302084e-04 -4.785201e-04 -4.222005e-04 -3.610851e-04
## ASV0937     -6.945327e-03 -7.241152e-03 -7.548831e-03 -7.868766e-03
## ASV11390    -2.874838e-03 -2.947285e-03 -3.020660e-03 -3.094961e-03
## ASV11966     3.411460e-03  3.562406e-03  3.718795e-03  3.880732e-03
## ASV12990     1.205435e-03  1.247083e-03  1.289899e-03  1.333913e-03
## ASV14797     3.415597e-03  3.512366e-03  3.611045e-03  3.711670e-03
## ASV14904    -2.874637e-03 -2.947061e-03 -3.020412e-03 -3.094687e-03
## ASV15304     2.532481e-03  2.654980e-03  2.782218e-03  2.914290e-03
## ASV16696    -2.874508e-03 -2.946921e-03 -3.020260e-03 -3.094522e-03
## ASV1690      3.544323e-03  3.690940e-03  3.841706e-03  3.996607e-03
## ASV2029      1.118768e-02  1.156768e-02  1.195742e-02  1.235702e-02
## ASV2834      6.845182e-03  7.103423e-03  7.369478e-03  7.643454e-03
## ASV4003      4.199075e-03  4.425338e-03  4.662840e-03  4.912063e-03
## ASV4064      5.152865e-03  5.350724e-03  5.554718e-03  5.764972e-03
## ASV4294      3.334331e-03  3.508684e-03  3.691147e-03  3.882003e-03
## ASV4609      2.685476e-04  2.901318e-04  3.130009e-04  3.372055e-04
## ASV6283     -2.874270e-03 -2.946662e-03 -3.019980e-03 -3.094221e-03
## ASV6491     -2.874202e-03 -2.946590e-03 -3.019903e-03 -3.094139e-03
## ASV7453      3.363024e-03  3.524224e-03  3.691652e-03  3.865428e-03
## ASV7959      1.937490e-03  2.048769e-03  2.165334e-03  2.287363e-03
## ASV8219      2.874104e-03  2.946487e-03  3.019796e-03  3.094028e-03
## ASV8547     -2.874062e-03 -2.946443e-03 -3.019750e-03 -3.093982e-03
## ASV9319      3.771281e-03  3.936465e-03  4.108505e-03  4.287663e-03
## ASV9382     -2.874016e-03 -2.946395e-03 -3.019703e-03 -3.093935e-03
## ASV11516    -2.873993e-03 -2.946374e-03 -3.019683e-03 -3.093917e-03
## ASV14377    -2.873978e-03 -2.946361e-03 -3.019673e-03 -3.093910e-03
## ASV1867      7.214370e-03  7.496612e-03  7.788217e-03  8.089419e-03
## ASV1895     -1.003160e-03 -1.036673e-03 -1.071578e-03 -1.107950e-03
## ASV3168      1.849509e-03  1.886178e-03  1.922374e-03  1.958047e-03
## ASV4449      4.393675e-03  4.537080e-03  4.684565e-03  4.836250e-03
## ASV6596      5.241821e-03  5.498426e-03  5.766319e-03  6.045866e-03
## ASV7492      2.311097e-04  2.832832e-04  3.387653e-04  3.976441e-04
## ASV9854     -1.275461e-03 -1.302146e-03 -1.328871e-03 -1.355619e-03
## ASV6296      2.873975e-03  2.946371e-03  3.019700e-03  3.093959e-03
## ASV4201      3.963808e-03  4.179712e-03  4.405821e-03  4.642494e-03
## ASV0552      1.223386e-02  1.270504e-02  1.318993e-02  1.368862e-02
## ASV3671      2.092509e-04  2.324616e-04  2.562550e-04  2.805660e-04
## ASV3529      6.036638e-04  6.529303e-04  7.041099e-04  7.571839e-04
## ASV1060      3.667350e-03  3.844378e-03  4.030036e-03  4.224728e-03
## ASV0239     -3.793242e-03 -3.867874e-03 -3.941665e-03 -4.014490e-03
## ASV5711     -4.377118e-03 -4.509989e-03 -4.645729e-03 -4.784361e-03
## ASV4152     -6.694068e-03 -6.917160e-03 -7.145504e-03 -7.379107e-03
## ASV1461      4.474666e-03  4.582809e-03  4.691993e-03  4.802207e-03
## ASV2877      4.561370e-03  4.694139e-03  4.828533e-03  4.964437e-03
## ASV0012      5.477968e-03  5.718341e-03  5.967684e-03  6.226189e-03
## ASV9823      5.681847e-04  5.637265e-04  5.581641e-04  5.514896e-04
## ASV0008      5.740718e-03  5.989427e-03  6.247401e-03  6.514848e-03
## ASV7832     -3.981149e-03 -4.115792e-03 -4.254054e-03 -4.395991e-03
## ASV1915      8.570689e-04  8.885634e-04  9.202230e-04  9.519658e-04
## ASV0055      2.832472e-03  2.916469e-03  3.001090e-03  3.086171e-03
## ASV0032      6.203199e-03  6.394354e-03  6.590117e-03  6.790632e-03
## ASV2977     -5.566427e-03 -5.748008e-03 -5.933539e-03 -6.122999e-03
## ASV0466      4.582826e-03  4.698215e-03  4.814175e-03  4.930580e-03
## ASV3866      7.576496e-03  7.888099e-03  8.211770e-03  8.547959e-03
## ASV0040      1.067637e-02  1.111422e-02  1.156709e-02  1.203529e-02
## ASV0496     -2.349041e-03 -2.486501e-03 -2.630478e-03 -2.781163e-03
## ASV0052      9.633782e-03  9.940020e-03  1.025254e-02  1.057133e-02
## ASV3828     -6.162585e-03 -6.389184e-03 -6.623545e-03 -6.865938e-03
## ASV1930      3.837294e-03  3.956909e-03  4.078643e-03  4.202470e-03
## ASV2126      6.278673e-03  6.488885e-03  6.704118e-03  6.924395e-03
## ASV0793      5.996353e-03  6.264388e-03  6.542574e-03  6.831174e-03
## ASV0299     -1.436676e-03 -1.472605e-03 -1.510424e-03 -1.550349e-03
## ASV0208      8.340840e-03  8.714479e-03  9.103507e-03  9.508438e-03
## ASV0511     -1.068573e-03 -1.051810e-03 -1.032785e-03 -1.011487e-03
## ASV1123     -2.746403e-03 -2.800870e-03 -2.854768e-03 -2.907988e-03
## ASV0099     -1.308007e-03 -1.297101e-03 -1.281318e-03 -1.260264e-03
## ASV0752     -1.179190e-03 -1.235154e-03 -1.293226e-03 -1.353456e-03
## ASV0883      5.390642e-04  5.690623e-04  6.003137e-04  6.328440e-04
## ASV0683      7.024560e-03  7.318449e-03  7.622724e-03  7.937594e-03
## ASV4117     -6.200243e-03 -6.421547e-03 -6.649528e-03 -6.884328e-03
## ASV2172      2.639365e-03  2.740998e-03  2.846062e-03  2.954646e-03
## ASV0330     -4.759590e-03 -4.936687e-03 -5.119262e-03 -5.307449e-03
## ASV0728      5.312387e-03  5.527852e-03  5.750667e-03  5.981015e-03
## ASV0499      1.101103e-02  1.149380e-02  1.199542e-02  1.251643e-02
## ASV0120     -8.866426e-03 -9.156049e-03 -9.451556e-03 -9.752874e-03
## ASV1446     -7.494913e-04 -8.291319e-04 -9.146760e-04 -1.006468e-03
## ASV17171    -6.147791e-03 -6.377843e-03 -6.615603e-03 -6.861283e-03
## ASV0533      2.617995e-03  2.739612e-03  2.866235e-03  2.997998e-03
## ASV2495     -3.553645e-03 -3.719679e-03 -3.892641e-03 -4.072718e-03
## ASV5582      1.039139e-03  1.045662e-03  1.050935e-03  1.054877e-03
## ASV1488      2.558208e-03  2.658900e-03  2.762439e-03  2.868827e-03
## ASV0682      7.498338e-03  7.817249e-03  8.147704e-03  8.489947e-03
## ASV0068     -1.564692e-03 -1.642689e-03 -1.722913e-03 -1.805290e-03
## ASV1987     -5.067837e-03 -5.309091e-03 -5.560711e-03 -5.823041e-03
## ASV0035     -2.068025e-03 -2.264214e-03 -2.474282e-03 -2.698955e-03
## ASV7192     -2.899805e-03 -2.964127e-03 -3.028018e-03 -3.091363e-03
## ASV0873     -2.695341e-04 -2.937075e-04 -3.186947e-04 -3.444656e-04
## ASV4749     -2.081480e-03 -2.230474e-03 -2.387697e-03 -2.553450e-03
## ASV2174      2.679403e-03  2.754686e-03  2.832458e-03  2.912910e-03
## ASV1476     -4.091348e-03 -4.262821e-03 -4.440593e-03 -4.624813e-03
## ASV0740     -1.060384e-02 -1.104807e-02 -1.150833e-02 -1.198501e-02
## ASV0170      1.958600e-03  2.036209e-03  2.116592e-03  2.199835e-03
## ASV2466     -8.177784e-03 -8.500568e-03 -8.834947e-03 -9.181264e-03
## ASV1709      5.558172e-03  5.744975e-03  5.936263e-03  6.132054e-03
## ASV6170     -6.172974e-03 -6.411748e-03 -6.658021e-03 -6.911916e-03
## ASV3673      7.160989e-03  7.441100e-03  7.730207e-03  8.028471e-03
## ASV1745      5.182055e-04  5.342581e-04  5.503469e-04  5.664228e-04
##                                                                    
## (Intercept) -6.904263e-03 -7.407402e-03 -7.938562e-03 -8.498693e-03
## ASV1236      3.939782e-03  4.047885e-03  4.157804e-03  4.269549e-03
## ASV0421     -7.254154e-03 -7.456424e-03 -7.662229e-03 -7.871597e-03
## ASV0691     -5.113080e-03 -5.234834e-03 -5.358279e-03 -5.483434e-03
## ASV0899      4.645623e-04  4.788727e-04  4.929357e-04  5.067269e-04
## ASV1004      8.111851e-03  8.325704e-03  8.542095e-03  8.760960e-03
## ASV1041     -5.278702e-03 -5.404540e-03 -5.530916e-03 -5.657755e-03
## ASV1058      7.937708e-03  8.170380e-03  8.407692e-03  8.649680e-03
## ASV12542     1.800035e-03  1.841635e-03  1.883954e-03  1.927026e-03
## ASV1294      9.893835e-03  1.019760e-02  1.050780e-02  1.082449e-02
## ASV13113     5.815931e-03  6.077276e-03  6.349292e-03  6.632320e-03
## ASV1318      7.905487e-03  8.127023e-03  8.352207e-03  8.581041e-03
## ASV2269     -2.291223e-03 -2.350939e-03 -2.411322e-03 -2.472363e-03
## ASV2542      7.814386e-03  8.128497e-03  8.453240e-03  8.788833e-03
## ASV2660     -4.057258e-03 -4.159556e-03 -4.263212e-03 -4.368236e-03
## ASV2737     -5.935494e-04 -6.139644e-04 -6.346052e-04 -6.554557e-04
## ASV2840      4.893596e-03  4.995115e-03  5.096561e-03  5.197878e-03
## ASV3053      2.840515e-04  2.961688e-04  3.089549e-04  3.224357e-04
## ASV3077      1.863937e-03  1.921050e-03  1.979618e-03  2.039670e-03
## ASV3134      1.121417e-02  1.170752e-02  1.222055e-02  1.275388e-02
## ASV3140      3.969722e-03  4.110777e-03  4.255460e-03  4.403794e-03
## ASV3579      3.166928e-03  3.322343e-03  3.483667e-03  3.650968e-03
## ASV6119     -2.290349e-03 -2.350185e-03 -2.410719e-03 -2.471940e-03
## ASV7557     -2.290347e-03 -2.350213e-03 -2.410781e-03 -2.472039e-03
## ASV8422      1.104705e-03  1.136198e-03  1.168510e-03  1.201666e-03
## ASV1086     -5.996717e-04 -6.203293e-04 -6.417845e-04 -6.640667e-04
## ASV1310      4.680014e-03  4.803460e-03  4.927470e-03  5.051884e-03
## ASV15750    -8.151875e-04 -8.261637e-04 -8.365968e-04 -8.464486e-04
## ASV16905    -2.290841e-03 -2.350851e-03 -2.411578e-03 -2.473007e-03
## ASV2033      6.895708e-03  7.163383e-03  7.439121e-03  7.723040e-03
## ASV2089      1.580308e-03  1.620369e-03  1.660757e-03  1.701450e-03
## ASV2127      6.746229e-03  6.944783e-03  7.146944e-03  7.352692e-03
## ASV2725      6.341296e-03  6.493485e-03  6.647080e-03  6.802062e-03
## ASV2804     -2.291366e-03 -2.351477e-03 -2.412310e-03 -2.473849e-03
## ASV3075      6.023841e-03  6.259434e-03  6.503693e-03  6.756885e-03
## ASV3327      6.601817e-03  6.863011e-03  7.132754e-03  7.411223e-03
## ASV3342      6.403760e-03  6.638437e-03  6.880004e-03  7.128572e-03
## ASV3532     -6.002963e-03 -6.242834e-03 -6.491803e-03 -6.750200e-03
## ASV3600      7.177011e-03  7.437708e-03  7.705839e-03  7.981505e-03
## ASV4013      4.849826e-03  4.989526e-03  5.131144e-03  5.274603e-03
## ASV4136      4.406585e-03  4.535186e-03  4.666551e-03  4.800718e-03
## ASV4195      2.292139e-03  2.352365e-03  2.413314e-03  2.474970e-03
## ASV4407     -2.292350e-03 -2.352601e-03 -2.413575e-03 -2.475253e-03
## ASV4717     -1.632909e-04 -1.695815e-04 -1.757296e-04 -1.817005e-04
## ASV6794      2.146859e-03  2.211996e-03  2.279078e-03  2.348177e-03
## ASV8324     -2.293038e-03 -2.353371e-03 -2.414428e-03 -2.476188e-03
## ASV8981      3.836838e-04  4.305440e-04  4.801830e-04  5.326760e-04
## ASV9859      4.440129e-03  4.672966e-03  4.917220e-03  5.173364e-03
## ASV0936     -4.030363e-03 -4.154648e-03 -4.281592e-03 -4.411219e-03
## ASV12683    -6.359278e-04 -6.556978e-04 -6.756039e-04 -6.956126e-04
## ASV1293      5.348159e-03  5.497879e-03  5.650238e-03  5.805249e-03
## ASV13055    -1.861818e-04 -1.769397e-04 -1.666453e-04 -1.552407e-04
## ASV17063    -2.294100e-03 -2.354500e-03 -2.415611e-03 -2.477409e-03
## ASV2228      2.294260e-03  2.354666e-03  2.415781e-03  2.477580e-03
## ASV2769      2.248792e-04  2.446963e-04  2.649555e-04  2.856109e-04
## ASV2803      8.309285e-04  8.519681e-04  8.735792e-04  8.957991e-04
## ASV2896      4.707255e-03  4.926193e-03  5.155714e-03  5.396339e-03
## ASV3062      2.505410e-03  2.628890e-03  2.757195e-03  2.890410e-03
## ASV3107      4.911785e-03  5.098271e-03  5.290650e-03  5.489035e-03
## ASV3265      6.786559e-03  6.966643e-03  7.148986e-03  7.333528e-03
## ASV3666     -4.346807e-04 -4.579215e-04 -4.822097e-04 -5.075636e-04
## ASV4497      1.710546e-03  1.760697e-03  1.811897e-03  1.864170e-03
## ASV6914     -1.072384e-03 -1.108827e-03 -1.146153e-03 -1.184361e-03
## ASV0576     -7.084025e-03 -7.262775e-03 -7.444358e-03 -7.628815e-03
## ASV0673      3.341259e-03  3.456558e-03  3.574222e-03  3.694239e-03
## ASV0772      3.206837e-03  3.324106e-03  3.445089e-03  3.569878e-03
## ASV0862     -1.088947e-03 -1.094698e-03 -1.099725e-03 -1.104051e-03
## ASV0898      3.611442e-03  3.753301e-03  3.899242e-03  4.049306e-03
## ASV0910      7.518073e-03  7.825731e-03  8.143854e-03  8.472682e-03
## ASV0964     -2.554040e-03 -2.611304e-03 -2.668887e-03 -2.726783e-03
## ASV10059     3.991148e-03  4.172616e-03  4.361505e-03  4.558063e-03
## ASV10263    -2.296284e-03 -2.356832e-03 -2.418088e-03 -2.480030e-03
## ASV1088      4.601106e-03  4.815685e-03  5.039295e-03  5.272221e-03
## ASV1101      4.159590e-03  4.258422e-03  4.356759e-03  4.454427e-03
## ASV1183      3.323697e-03  3.439300e-03  3.558061e-03  3.680029e-03
## ASV11956     6.162364e-04  6.297158e-04  6.436491e-04  6.580740e-04
## ASV12774    -6.874252e-04 -7.159922e-04 -7.454767e-04 -7.758910e-04
## ASV1321      2.955312e-03  3.098562e-03  3.247195e-03  3.401290e-03
## ASV13793    -2.296773e-03 -2.357349e-03 -2.418639e-03 -2.480624e-03
## ASV14482    -3.933298e-04 -4.033166e-04 -4.131311e-04 -4.227444e-04
## ASV15483     2.414113e-03  2.507000e-03  2.602881e-03  2.701833e-03
## ASV2062      1.222876e-02  1.262578e-02  1.303179e-02  1.344684e-02
## ASV2132      6.894182e-03  7.158273e-03  7.430443e-03  7.710810e-03
## ASV2413      7.134528e-03  7.355339e-03  7.581250e-03  7.812337e-03
## ASV2490      3.866618e-03  3.960545e-03  4.055391e-03  4.151141e-03
## ASV2594      3.647365e-03  3.809804e-03  3.979435e-03  4.156539e-03
## ASV2822     -2.297426e-03 -2.358080e-03 -2.419464e-03 -2.481564e-03
## ASV2863      4.022342e-03  4.137723e-03  4.255391e-03  4.375373e-03
## ASV2910      5.100123e-03  5.242228e-03  5.387075e-03  5.534718e-03
## ASV2980      1.688007e-03  1.725038e-03  1.762066e-03  1.799067e-03
## ASV3307      2.297935e-03  2.358665e-03  2.420144e-03  2.482361e-03
## ASV3474      6.213559e-03  6.462711e-03  6.719340e-03  6.983491e-03
## ASV3502      9.609342e-03  9.952557e-03  1.030635e-02  1.067102e-02
## ASV4236      3.429473e-03  3.514855e-03  3.601360e-03  3.688996e-03
## ASV4842     -1.249453e-03 -1.278223e-03 -1.306944e-03 -1.335591e-03
## ASV4894     -2.298499e-03 -2.359320e-03 -2.420906e-03 -2.483252e-03
## ASV5290      3.349320e-03  3.449844e-03  3.551981e-03  3.655709e-03
## ASV5501      9.015138e-04  9.459797e-04  9.926373e-04  1.041571e-03
## ASV5795      3.008794e-03  3.124824e-03  3.244207e-03  3.366962e-03
## ASV5987     -2.299111e-03 -2.360033e-03 -2.421740e-03 -2.484228e-03
## ASV6267     -2.299327e-03 -2.360288e-03 -2.422041e-03 -2.484582e-03
## ASV6862      3.864966e-03  3.965855e-03  4.068635e-03  4.173344e-03
## ASV7145      8.281919e-04  8.612012e-04  8.956672e-04  9.316391e-04
## ASV7673     -2.299857e-03 -2.360904e-03 -2.422756e-03 -2.485410e-03
## ASV7789      2.723945e-03  2.868142e-03  3.018752e-03  3.175952e-03
## ASV7809      5.034771e-04  5.409509e-04  5.800375e-04  6.207418e-04
## ASV8002     -2.300615e-03 -2.361792e-03 -2.423794e-03 -2.486620e-03
## ASV8205      1.970465e-03  2.050710e-03  2.133789e-03  2.219757e-03
## ASV9155     -1.603963e-03 -1.641917e-03 -1.680102e-03 -1.718507e-03
## ASV9221      8.327750e-04  8.966410e-04  9.640133e-04  1.035009e-03
## ASV9311     -2.301885e-03 -2.363265e-03 -2.425497e-03 -2.488581e-03
## ASV9557     -2.302260e-03 -2.363697e-03 -2.425993e-03 -2.489148e-03
## ASV9936     -2.302648e-03 -2.364142e-03 -2.426502e-03 -2.489728e-03
## ASV1445      7.780910e-03  8.082619e-03  8.394305e-03  8.716194e-03
## ASV4232      8.244922e-03  8.626290e-03  9.024263e-03  9.439444e-03
## ASV6479      1.723017e-03  1.834839e-03  1.952366e-03  2.075776e-03
## ASV0142     -1.112461e-02 -1.142133e-02 -1.172247e-02 -1.202801e-02
## ASV0378     -2.561644e-03 -2.585747e-03 -2.607566e-03 -2.626998e-03
## ASV1122      1.002302e-02  1.039227e-02  1.077204e-02  1.116243e-02
## ASV0123     -1.079667e-02 -1.108037e-02 -1.136799e-02 -1.165949e-02
## ASV2064      6.916500e-04  7.018563e-04  7.122381e-04  7.228434e-04
## ASV4459     -1.181531e-03 -1.214372e-03 -1.248051e-03 -1.282609e-03
## ASV0448      4.732476e-03  4.952817e-03  5.181591e-03  5.418976e-03
## ASV0397      6.849396e-03  7.086038e-03  7.328779e-03  7.577679e-03
## ASV0485      9.096728e-03  9.415271e-03  9.743199e-03  1.008072e-02
## ASV1566      7.883319e-03  8.151287e-03  8.425997e-03  8.707523e-03
## ASV1365      5.192657e-03  5.364272e-03  5.539328e-03  5.717772e-03
## ASV1065      1.085311e-02  1.123887e-02  1.163525e-02  1.204237e-02
## ASV0722     -1.241227e-04 -1.347585e-04 -1.465401e-04 -1.595617e-04
## ASV12660    -3.524828e-03 -3.615451e-03 -3.707322e-03 -3.800440e-03
## ASV0223      2.046588e-04  2.309451e-04  2.593926e-04  2.901204e-04
## ASV0229      5.703956e-03  5.934986e-03  6.174199e-03  6.421815e-03
## ASV0877     -9.003913e-04 -9.188403e-04 -9.378739e-04 -9.575536e-04
## ASV0983      8.401206e-03  8.661013e-03  8.926304e-03  9.197093e-03
## ASV0626     -9.865935e-04 -9.811163e-04 -9.747253e-04 -9.674610e-04
## ASV4146     -5.528597e-04 -5.872111e-04 -6.244386e-04 -6.647712e-04
## ASV4175     -5.795534e-03 -5.987639e-03 -6.184111e-03 -6.384948e-03
## ASV2082     -2.005027e-03 -2.126294e-03 -2.253573e-03 -2.387049e-03
## ASV2272      5.166217e-03  5.371497e-03  5.583372e-03  5.801943e-03
## ASV2245     -5.431225e-03 -5.626828e-03 -5.828152e-03 -6.035311e-03
## ASV0590     -5.171447e-03 -5.404829e-03 -5.647018e-03 -5.898238e-03
## ASV0217      1.861648e-06  1.132656e-04  2.319979e-04  3.582448e-04
## ASV0416      2.371661e-03  2.392366e-03  2.410641e-03  2.426318e-03
## ASV1056      7.481369e-03  7.771908e-03  8.070635e-03  8.377600e-03
## ASV7777     -5.415791e-03 -5.623025e-03 -5.837784e-03 -6.060357e-03
## ASV0455      1.300974e-03  1.338816e-03  1.376467e-03  1.413816e-03
## ASV0604      2.639079e-03  2.764758e-03  2.895192e-03  3.030493e-03
## ASV6100     -5.210151e-03 -5.416394e-03 -5.630418e-03 -5.852513e-03
## ASV11359    -4.883415e-03 -5.035997e-03 -5.191493e-03 -5.349869e-03
## ASV6604      4.701040e-03  4.892927e-03  5.091393e-03  5.296571e-03
## ASV5004     -3.011575e-03 -3.119975e-03 -3.232034e-03 -3.347880e-03
## ASV1483     -2.862572e-03 -2.962751e-03 -3.065664e-03 -3.171335e-03
## ASV9773     -6.421447e-03 -6.663352e-03 -6.913413e-03 -7.171872e-03
## ASV4059      1.696008e-03  1.782929e-03  1.873169e-03  1.966758e-03
## ASV1193      9.744528e-03  1.007696e-02  1.041770e-02  1.076680e-02
## ASV4610      5.614475e-04  5.989096e-04  6.369842e-04  6.755691e-04
## ASV0742     -1.166279e-03 -1.157222e-03 -1.146769e-03 -1.134953e-03
## ASV1502     -9.066467e-04 -9.564756e-04 -1.008223e-03 -1.061903e-03
## ASV0195     -2.073607e-03 -2.168943e-03 -2.268032e-03 -2.371000e-03
## ASV1213      1.650106e-03  1.667018e-03  1.682335e-03  1.695941e-03
## ASV1648     -4.755069e-03 -4.941099e-03 -5.134201e-03 -5.334646e-03
## ASV6984     -3.902935e-03 -4.067032e-03 -4.237984e-03 -4.416074e-03
## ASV0396      9.887308e-04  1.093611e-03  1.203039e-03  1.316990e-03
## ASV4297      3.683268e-03  3.781266e-03  3.880806e-03  3.981890e-03
## ASV2622      9.339017e-03  9.618020e-03  9.903158e-03  1.019453e-02
## ASV3512      4.020067e-03  4.238072e-03  4.466930e-03  4.707090e-03
## ASV2411      5.213397e-03  5.421621e-03  5.635878e-03  5.856144e-03
## ASV2291     -2.224334e-03 -2.335204e-03 -2.450538e-03 -2.570429e-03
## ASV0807      7.135985e-03  7.436873e-03  7.747575e-03  8.068234e-03
## ASV1292      2.325301e-03  2.408805e-03  2.495343e-03  2.585034e-03
## ASV1035      8.108170e-04  8.390683e-04  8.685913e-04  8.994495e-04
## ASV0070      7.807086e-05  1.650189e-04  2.587808e-04  3.596358e-04
## ASV0255      5.749480e-04  5.561454e-04  5.331444e-04  5.055777e-04
## ASV0057     -7.155654e-03 -7.271340e-03 -7.383254e-03 -7.491049e-03
## ASV0077      4.358962e-04  5.001360e-04  5.673650e-04  6.375247e-04
## ASV0625      8.689924e-03  8.908774e-03  9.129475e-03  9.351890e-03
## ASV2464      3.930977e-03  4.029901e-03  4.130104e-03  4.231574e-03
## ASV1315      1.300295e-02  1.352265e-02  1.405886e-02  1.461179e-02
## ASV2673      1.049767e-02  1.096330e-02  1.144764e-02  1.195129e-02
## ASV2161      4.517347e-03  4.721123e-03  4.933062e-03  5.153396e-03
## ASV0337     -4.322229e-03 -4.452503e-03 -4.585290e-03 -4.720598e-03
## ASV7680     -6.254516e-03 -6.486085e-03 -6.724654e-03 -6.970335e-03
## ASV0611      1.564172e-02  1.628908e-02  1.696008e-02  1.765536e-02
## ASV3118     -4.893476e-03 -5.078090e-03 -5.268227e-03 -5.463961e-03
## ASV1284      5.215415e-03  5.411323e-03  5.612678e-03  5.819493e-03
## ASV0889      3.349426e-03  3.474863e-03  3.604947e-03  3.739870e-03
## ASV4649     -3.640599e-03 -3.768685e-03 -3.900331e-03 -4.035584e-03
## ASV1108     -6.576696e-03 -6.863441e-03 -7.160864e-03 -7.469211e-03
## ASV0738      3.499909e-03  3.742995e-03  3.999328e-03  4.269435e-03
## ASV0473      9.818748e-04  1.026150e-03  1.072248e-03  1.120237e-03
## ASV0598     -3.018752e-03 -3.067937e-03 -3.115784e-03 -3.162156e-03
## ASV0429      7.265222e-03  7.483527e-03  7.705976e-03  7.932574e-03
## ASV1549      1.170958e-02  1.221081e-02  1.272969e-02  1.326650e-02
## ASV1203      5.887591e-03  6.073706e-03  6.263370e-03  6.456520e-03
## ASV4532      1.755414e-04  1.947292e-04  2.160961e-04  2.398275e-04
## ASV0274     -4.005746e-03 -4.095773e-03 -4.186806e-03 -4.278896e-03
## ASV0163     -5.401648e-03 -5.506647e-03 -5.611409e-03 -5.715883e-03
## ASV1298      2.570269e-03  2.650539e-03  2.733920e-03  2.820610e-03
## ASV9424     -8.957279e-03 -9.313642e-03 -9.682563e-03 -1.006439e-02
## ASV0412      1.097912e-02  1.133518e-02  1.169930e-02  1.207150e-02
## ASV0284      3.504366e-03  3.575483e-03  3.645561e-03  3.714401e-03
## ASV0620     -5.428386e-03 -5.651053e-03 -5.881119e-03 -6.118726e-03
## ASV0153     -9.996249e-03 -1.037539e-02 -1.076479e-02 -1.116440e-02
## ASV0498      3.296803e-03  3.446378e-03  3.599598e-03  3.756315e-03
## ASV0097      8.175699e-03  8.531059e-03  8.899778e-03  9.282177e-03
## ASV0104     -2.620534e-02 -2.707523e-02 -2.796584e-02 -2.887731e-02
## ASV1282      4.976968e-03  5.140325e-03  5.306440e-03  5.475183e-03
## ASV3883     -3.416464e-03 -3.538020e-03 -3.661799e-03 -3.787671e-03
## ASV0801      4.253401e-03  4.445059e-03  4.644487e-03  4.851942e-03
## ASV1611     -1.201128e-02 -1.247215e-02 -1.294754e-02 -1.343771e-02
## ASV0227     -5.972855e-03 -6.238850e-03 -6.515144e-03 -6.802053e-03
## ASV0833      6.087624e-03  6.340985e-03  6.602490e-03  6.872244e-03
## ASV0718      1.014386e-02  1.049682e-02  1.085846e-02  1.122879e-02
## ASV1139      9.569267e-04  9.140266e-04  8.661646e-04  8.131360e-04
## ASV0766     -2.044287e-03 -2.102704e-03 -2.162438e-03 -2.223525e-03
## ASV2091      9.581367e-03  9.829543e-03  1.008102e-02  1.033579e-02
## ASV1238      1.135366e-03  1.218086e-03  1.304215e-03  1.393751e-03
## ASV9193     -2.841392e-03 -2.974687e-03 -3.112351e-03 -3.254377e-03
## ASV0290     -1.717746e-03 -1.767706e-03 -1.816829e-03 -1.864897e-03
## ASV0231      9.913447e-03  1.023929e-02  1.057236e-02  1.091262e-02
## ASV0185      8.923818e-03  9.450735e-03  1.000395e-02  1.058441e-02
## ASV2330      2.365073e-03  2.436747e-03  2.510394e-03  2.586095e-03
## ASV3119     -6.255427e-03 -6.555966e-03 -6.869031e-03 -7.194993e-03
## ASV2368     -6.712819e-03 -7.020191e-03 -7.340767e-03 -7.675015e-03
## ASV0122     -2.520534e-03 -2.585372e-03 -2.651734e-03 -2.719736e-03
## ASV1044      9.663734e-03  1.008938e-02  1.053111e-02  1.098932e-02
## ASV0160     -5.167555e-03 -5.253771e-03 -5.339056e-03 -5.423388e-03
## ASV0326      5.945913e-03  6.140213e-03  6.338274e-03  6.540009e-03
## ASV1388      1.027254e-02  1.062815e-02  1.099347e-02  1.136866e-02
## ASV0792      9.849644e-03  1.012739e-02  1.040895e-02  1.069421e-02
## ASV0036     -8.411645e-03 -8.705804e-03 -9.005937e-03 -9.311840e-03
## ASV2125      1.165118e-02  1.202733e-02  1.241110e-02  1.280239e-02
## ASV1075      3.274632e-03  3.416672e-03  3.564012e-03  3.716786e-03
## ASV0390      5.024257e-03  5.296085e-03  5.581525e-03  5.881139e-03
## ASV3790     -1.088237e-02 -1.129010e-02 -1.171024e-02 -1.214302e-02
## ASV1535     -1.835101e-03 -1.926170e-03 -2.020624e-03 -2.118486e-03
## ASV0263      2.199165e-03  2.282104e-03  2.367754e-03  2.456185e-03
## ASV0675      2.067159e-02  2.151635e-02  2.238965e-02  2.329201e-02
## ASV3348      2.747161e-03  2.881246e-03  3.021180e-03  3.167157e-03
## ASV0058     -1.383476e-02 -1.425263e-02 -1.467751e-02 -1.510928e-02
## ASV4142      3.245630e-03  3.342577e-03  3.441723e-03  3.543122e-03
## ASV0059     -1.155900e-02 -1.189351e-02 -1.223260e-02 -1.257610e-02
## ASV0013     -2.679767e-02 -2.769954e-02 -2.862398e-02 -2.957123e-02
## ASV0033     -9.563678e-03 -9.917597e-03 -1.028052e-02 -1.065237e-02
## ASV4354     -3.068795e-03 -3.171406e-03 -3.276797e-03 -3.384992e-03
## ASV0022     -9.785008e-03 -1.013337e-02 -1.048935e-02 -1.085276e-02
## ASV0134     -3.472430e-03 -3.638629e-03 -3.812678e-03 -3.994961e-03
## ASV0415      2.463710e-04  2.976003e-04  3.516555e-04  4.085932e-04
## ASV10103    -6.617549e-03 -6.858986e-03 -7.106989e-03 -7.361597e-03
## ASV1613      7.854167e-03  8.062970e-03  8.273516e-03  8.485637e-03
## ASV0135      3.064652e-03  3.282827e-03  3.513172e-03  3.756159e-03
## ASV0469     -1.024995e-02 -1.056697e-02 -1.089139e-02 -1.122332e-02
## ASV0471      8.200306e-03  8.509042e-03  8.828343e-03  9.158560e-03
## ASV0451     -3.570061e-03 -3.729631e-03 -3.894771e-03 -4.065555e-03
## ASV0747      4.458276e-03  4.639642e-03  4.826178e-03  5.017882e-03
## ASV1314     -7.527158e-03 -7.895389e-03 -8.280468e-03 -8.683031e-03
## ASV0425     -9.592714e-03 -9.821786e-03 -1.005282e-02 -1.028578e-02
## ASV0559     -6.408105e-03 -6.629263e-03 -6.858529e-03 -7.096255e-03
## ASV0148     -5.085386e-03 -5.159000e-03 -5.228974e-03 -5.294999e-03
## ASV0129     -4.853877e-04 -3.939221e-04 -2.945944e-04 -1.871128e-04
## ASV1072      2.170169e-03  2.193299e-03  2.214985e-03  2.235210e-03
## ASV2390      1.392358e-03  1.394071e-03  1.393580e-03  1.390796e-03
## ASV0548      9.670340e-03  1.002632e-02  1.039274e-02  1.076976e-02
## ASV0168     -1.183688e-02 -1.221872e-02 -1.261034e-02 -1.301191e-02
## ASV0066     -8.765137e-03 -9.022420e-03 -9.283129e-03 -9.547058e-03
## ASV0468     -3.956740e-03 -4.114169e-03 -4.277837e-03 -4.448012e-03
## ASV0172      1.258656e-03  1.393277e-03  1.535824e-03  1.686544e-03
## ASV0236     -6.953126e-04 -6.057564e-04 -5.091181e-04 -4.052305e-04
## ASV0250      5.931724e-03  6.310474e-03  6.708877e-03  7.127633e-03
## ASV0338      1.330615e-03  1.412597e-03  1.497489e-03  1.585296e-03
## ASV0450     -1.254323e-04 -1.417318e-04 -1.599080e-04 -1.801202e-04
## ASV0377      1.064777e-02  1.099698e-02  1.135328e-02  1.171655e-02
## ASV1022      3.593483e-03  3.743805e-03  3.900053e-03  4.062431e-03
## ASV6174     -7.246229e-04 -7.517820e-04 -7.794978e-04 -8.077038e-04
## ASV0786      6.074112e-04  6.160566e-04  6.245548e-04  6.329078e-04
## ASV0053     -1.324469e-02 -1.369988e-02 -1.416642e-02 -1.464436e-02
## ASV0697     -2.130716e-03 -2.164151e-03 -2.196939e-03 -2.229074e-03
## ASV0785      9.856921e-03  1.020852e-02  1.057095e-02  1.094452e-02
## ASV1967     -4.811423e-03 -4.944010e-03 -5.078828e-03 -5.215872e-03
## ASV0385     -1.547041e-03 -1.570283e-03 -1.593366e-03 -1.616320e-03
## ASV0295      3.183777e-03  3.393348e-03  3.613967e-03  3.846010e-03
## ASV0072     -7.028545e-03 -7.164601e-03 -7.298409e-03 -7.429698e-03
## ASV0157     -9.470615e-04 -8.544290e-04 -7.509562e-04 -6.359851e-04
## ASV0501      6.824581e-03  7.112755e-03  7.410517e-03  7.717996e-03
## ASV10729    -8.637014e-03 -8.947326e-03 -9.265901e-03 -9.592798e-03
## ASV1470      2.788646e-03  2.850781e-03  2.912360e-03  2.973240e-03
## ASV0050     -2.356560e-02 -2.429952e-02 -2.504819e-02 -2.581155e-02
## ASV0411      6.055491e-04  6.541191e-04  7.042264e-04  7.557417e-04
## ASV0549      7.021792e-03  7.329891e-03  7.649786e-03  7.981784e-03
## ASV0184      3.452404e-03  3.594071e-03  3.741082e-03  3.893588e-03
## ASV0705      4.109609e-03  4.248478e-03  4.389866e-03  4.533671e-03
## ASV1715      9.928818e-03  1.029269e-02  1.066730e-02  1.105280e-02
## ASV0603      2.030791e-03  2.144257e-03  2.263981e-03  2.390254e-03
## ASV0826      2.055879e-03  2.099454e-03  2.142876e-03  2.186088e-03
## ASV0034     -9.187460e-03 -9.418672e-03 -9.651119e-03 -9.884609e-03
## ASV0838      1.651429e-03  1.665622e-03  1.676769e-03  1.684595e-03
## ASV0614     -5.696024e-03 -5.857939e-03 -6.021863e-03 -6.187686e-03
## ASV0014     -2.336163e-02 -2.411180e-02 -2.487877e-02 -2.566264e-02
## ASV0585     -1.672788e-03 -1.722953e-03 -1.773342e-03 -1.823860e-03
## ASV0016     -2.407854e-02 -2.485799e-02 -2.565528e-02 -2.647050e-02
## ASV5394     -6.790016e-03 -7.014521e-03 -7.242860e-03 -7.474803e-03
## ASV0666      5.010163e-03  5.163752e-03  5.320296e-03  5.479793e-03
## ASV2085     -5.330737e-04 -6.157978e-04 -7.034315e-04 -7.961282e-04
## ASV0003     -2.149102e-02 -2.217394e-02 -2.287210e-02 -2.358563e-02
## ASV0346      2.343324e-03  2.487615e-03  2.638008e-03  2.794609e-03
## ASV0267     -1.735389e-03 -1.749564e-03 -1.763087e-03 -1.776058e-03
## ASV0353      8.463670e-03  8.852949e-03  9.257236e-03  9.676868e-03
## ASV2419      5.839327e-03  6.018970e-03  6.202014e-03  6.388394e-03
## ASV0447      6.289125e-03  6.580661e-03  6.883080e-03  7.196630e-03
## ASV0654      1.118066e-02  1.156592e-02  1.196000e-02  1.236288e-02
## ASV0151      4.419424e-03  4.664678e-03  4.921704e-03  5.190900e-03
## ASV0065     -8.619008e-03 -8.878771e-03 -9.142885e-03 -9.411277e-03
## ASV0527      6.574455e-03  6.787684e-03  7.005502e-03  7.227893e-03
## ASV4055     -4.185687e-03 -4.398824e-03 -4.622928e-03 -4.858548e-03
## ASV0166     -5.922728e-03 -6.076544e-03 -6.232356e-03 -6.390162e-03
## ASV0417     -5.980207e-03 -6.173114e-03 -6.370883e-03 -6.573606e-03
## ASV0078     -3.156858e-03 -3.181178e-03 -3.200558e-03 -3.214622e-03
## ASV0322     -4.307645e-03 -4.388529e-03 -4.468202e-03 -4.546554e-03
## ASV0156     -7.332503e-03 -7.563250e-03 -7.799718e-03 -8.042039e-03
## ASV0648     -8.996116e-03 -9.343012e-03 -9.700800e-03 -1.006967e-02
## ASV0407      1.621792e-03  1.709459e-03  1.801227e-03  1.897237e-03
## ASV2030     -1.222740e-03 -1.276722e-03 -1.333925e-03 -1.394537e-03
## ASV0300      6.912288e-03  7.206644e-03  7.510532e-03  7.824025e-03
## ASV1150      4.742280e-04  5.204860e-04  5.691763e-04  6.203178e-04
## ASV0958      8.221875e-03  8.633914e-03  9.065150e-03  9.516303e-03
## ASV0216     -6.458863e-03 -6.669983e-03 -6.888302e-03 -7.114161e-03
## ASV0446      1.456597e-02  1.514392e-02  1.573968e-02  1.635346e-02
## ASV0367     -3.718481e-03 -3.847011e-03 -3.979224e-03 -4.115199e-03
## ASV0200     -7.585875e-03 -7.864598e-03 -8.151761e-03 -8.447523e-03
## ASV0334     -4.448452e-04 -3.932222e-04 -3.383976e-04 -2.803805e-04
## ASV1311      4.290999e-03  4.411649e-03  4.533664e-03  4.656941e-03
## ASV0458      5.383064e-03  5.571572e-03  5.765310e-03  5.964357e-03
## ASV1371      2.836559e-04  2.942107e-04  3.048789e-04  3.156370e-04
## ASV0418      7.146225e-03  7.416027e-03  7.694709e-03  7.982497e-03
## ASV0004      7.671125e-03  7.923985e-03  8.182506e-03  8.446672e-03
## ASV1943      5.092706e-03  5.254493e-03  5.419922e-03  5.589014e-03
## ASV1495     -3.826996e-03 -4.035415e-03 -4.253714e-03 -4.482227e-03
## ASV0901     -1.144802e-02 -1.192426e-02 -1.241800e-02 -1.292972e-02
## ASV0628      3.665743e-03  3.727177e-03  3.785460e-03  3.840211e-03
## ASV0400      1.392310e-03  1.405709e-03  1.416483e-03  1.424343e-03
## ASV0116     -9.683708e-03 -1.009846e-02 -1.052829e-02 -1.097356e-02
## ASV0788      5.977428e-03  6.186778e-03  6.401575e-03  6.621881e-03
## ASV0117      5.917852e-03  6.192188e-03  6.477652e-03  6.774555e-03
## ASV3137      8.729976e-04  9.054348e-04  9.395326e-04  9.754364e-04
## ASV0001      6.739256e-03  6.898346e-03  7.058440e-03  7.219486e-03
## ASV1651      4.986114e-03  5.140334e-03  5.299214e-03  5.462983e-03
## ASV1692      9.207121e-03  9.595294e-03  9.997496e-03  1.041410e-02
## ASV0660      1.175365e-03  1.120516e-03  1.058366e-03  9.885246e-04
## ASV0508     -5.747130e-05 -6.972549e-05 -8.295511e-05 -9.725070e-05
## ASV1660     -3.929829e-03 -4.085785e-03 -4.246055e-03 -4.410615e-03
## ASV0233      2.798663e-03  2.942198e-03  3.092667e-03  3.250353e-03
## ASV1343     -7.851281e-03 -8.159041e-03 -8.477362e-03 -8.806531e-03
## ASV0209      4.412598e-03  4.522563e-03  4.633854e-03  4.746455e-03
## ASV0193     -6.706280e-03 -6.905538e-03 -7.109090e-03 -7.317000e-03
## ASV0357      2.142791e-03  2.310884e-03  2.489478e-03  2.679060e-03
## ASV0198      2.279939e-03  2.383442e-03  2.491534e-03  2.604379e-03
## ASV0007      6.402603e-03  6.554247e-03  6.706877e-03  6.860443e-03
## ASV1772     -1.969522e-04 -1.574282e-04 -1.123487e-04 -6.122806e-05
## ASV0009      5.895994e-03  6.031349e-03  6.167411e-03  6.304142e-03
## ASV0006      6.620033e-04  6.172848e-04  5.688582e-04  5.166654e-04
## ASV0011     -1.131067e-02 -1.175271e-02 -1.220902e-02 -1.267986e-02
## ASV0015      6.401320e-03  6.604741e-03  6.811863e-03  7.022583e-03
## ASV0017      6.762096e-03  6.980444e-03  7.203196e-03  7.430283e-03
## ASV0235     -6.264654e-03 -6.498834e-03 -6.740338e-03 -6.989356e-03
## ASV0382      2.963033e-03  3.081748e-03  3.201663e-03  3.322467e-03
## ASV2357      9.627826e-03  1.000522e-02  1.039549e-02  1.079893e-02
## ASV0567     -6.063598e-03 -6.295562e-03 -6.536210e-03 -6.785842e-03
## ASV0165      6.763132e-03  6.998552e-03  7.240463e-03  7.488989e-03
## ASV0005      1.136634e-02  1.168156e-02  1.200043e-02  1.232275e-02
## ASV0384      1.828043e-03  1.988144e-03  2.159346e-03  2.342249e-03
## ASV0002      4.571475e-03  4.779911e-03  4.996299e-03  5.220792e-03
## ASV3017      6.367532e-03  6.550928e-03  6.737791e-03  6.928145e-03
## ASV0091      3.772943e-03  3.915388e-03  4.061330e-03  4.210689e-03
## ASV0186     -8.562427e-03 -8.848066e-03 -9.139195e-03 -9.435663e-03
## ASV0370      1.533508e-03  1.617506e-03  1.706113e-03  1.799545e-03
## ASV0018      1.228923e-02  1.264867e-02  1.301371e-02  1.338423e-02
## ASV1377      1.086170e-02  1.119883e-02  1.154318e-02  1.189480e-02
## ASV0019      1.239305e-02  1.275956e-02  1.313212e-02  1.351064e-02
## ASV0023     -1.644662e-03 -1.761660e-03 -1.883656e-03 -2.010679e-03
## ASV2194      6.077098e-03  6.335041e-03  6.602469e-03  6.879609e-03
## ASV1155      9.041956e-04  9.714681e-04  1.041942e-03  1.115692e-03
## ASV0510     -2.323224e-03 -2.343028e-03 -2.361567e-03 -2.378837e-03
## ASV2371     -3.411877e-03 -3.491172e-03 -3.570812e-03 -3.650740e-03
## ASV0024     -2.362952e-03 -2.506349e-03 -2.655571e-03 -2.810666e-03
## ASV2452      4.398115e-03  4.487924e-03  4.577483e-03  4.666747e-03
## ASV2332      2.521585e-03  2.654761e-03  2.793092e-03  2.936655e-03
## ASV2591      2.302498e-03  2.417558e-03  2.536554e-03  2.659509e-03
## ASV0521      1.181133e-02  1.230373e-02  1.281396e-02  1.334248e-02
## ASV5542      3.830929e-03  3.983848e-03  4.141661e-03  4.304457e-03
## ASV0336     -4.206155e-03 -4.359819e-03 -4.519012e-03 -4.683995e-03
## ASV10102     7.087810e-03  7.341216e-03  7.600828e-03  7.866617e-03
## ASV16823    -3.171571e-03 -3.247853e-03 -3.325066e-03 -3.403211e-03
## ASV3104      3.171364e-03  3.247625e-03  3.324814e-03  3.402934e-03
## ASV0781      2.068419e-03  2.137032e-03  2.207940e-03  2.281247e-03
## ASV10899     4.773965e-03  5.005030e-03  5.245525e-03  5.495700e-03
## ASV11222    -3.171108e-03 -3.247342e-03 -3.324502e-03 -3.402591e-03
## ASV11327    -3.170912e-03 -3.247125e-03 -3.324264e-03 -3.402331e-03
## ASV12458    -3.170722e-03 -3.246917e-03 -3.324037e-03 -3.402082e-03
## ASV1636     -2.407961e-03 -2.462201e-03 -2.517215e-03 -2.573038e-03
## ASV1890     -3.903535e-03 -4.035018e-03 -4.171113e-03 -4.312027e-03
## ASV2898      9.112305e-03  9.389725e-03  9.673281e-03  9.963086e-03
## ASV8328      1.969374e-03  2.109709e-03  2.257283e-03  2.412314e-03
## ASV0709     -7.544529e-03 -7.770086e-03 -7.999950e-03 -8.234133e-03
## ASV0856      2.431020e-03  2.540377e-03  2.653653e-03  2.770910e-03
## ASV0909     -2.950098e-04 -2.238123e-04 -1.473314e-04 -6.540757e-05
## ASV0937     -8.201364e-03 -8.547036e-03 -8.906199e-03 -9.279268e-03
## ASV11390    -3.170184e-03 -3.246329e-03 -3.323395e-03 -3.401385e-03
## ASV11966     4.048318e-03  4.221649e-03  4.400818e-03  4.585912e-03
## ASV12990     1.379153e-03  1.425647e-03  1.473424e-03  1.522511e-03
## ASV14797     3.814281e-03  3.918919e-03  4.025625e-03  4.134442e-03
## ASV14904    -3.169883e-03 -3.245999e-03 -3.323035e-03 -3.400993e-03
## ASV15304     3.051287e-03  3.193298e-03  3.340404e-03  3.492686e-03
## ASV16696    -3.169706e-03 -3.245809e-03 -3.322831e-03 -3.400776e-03
## ASV1690      4.155623e-03  4.318722e-03  4.485867e-03  4.657011e-03
## ASV2029      1.276657e-02  1.318616e-02  1.361589e-02  1.405583e-02
## ASV2834      7.925457e-03  8.215580e-03  8.513911e-03  8.820529e-03
## ASV4003      5.173506e-03  5.447684e-03  5.735130e-03  6.036394e-03
## ASV4064      5.981612e-03  6.204770e-03  6.434575e-03  6.671164e-03
## ASV4294      4.081537e-03  4.290036e-03  4.507788e-03  4.735081e-03
## ASV4609      3.627961e-04  3.898228e-04  4.183352e-04  4.483821e-04
## ASV6283     -3.169382e-03 -3.245462e-03 -3.322463e-03 -3.400384e-03
## ASV6491     -3.169296e-03 -3.245373e-03 -3.322369e-03 -3.400287e-03
## ASV7453      4.045663e-03  4.232463e-03  4.425926e-03  4.626142e-03
## ASV7959      2.415041e-03  2.548550e-03  2.688077e-03  2.833812e-03
## ASV8219      3.169182e-03  3.245256e-03  3.322251e-03  3.400169e-03
## ASV8547     -3.169136e-03 -3.245210e-03 -3.322207e-03 -3.400127e-03
## ASV9319      4.474207e-03  4.668415e-03  4.870572e-03  5.080970e-03
## ASV9382     -3.169089e-03 -3.245166e-03 -3.322166e-03 -3.400090e-03
## ASV11516    -3.169075e-03 -3.245156e-03 -3.322160e-03 -3.400091e-03
## ASV14377    -3.169073e-03 -3.245159e-03 -3.322170e-03 -3.400108e-03
## ASV1867      8.400460e-03  8.721586e-03  9.053047e-03  9.395098e-03
## ASV1895     -1.145865e-03 -1.185401e-03 -1.226639e-03 -1.269661e-03
## ASV3168      1.993144e-03  2.027616e-03  2.061414e-03  2.094490e-03
## ASV4449      4.992262e-03  5.152734e-03  5.317802e-03  5.487608e-03
## ASV6596      6.337439e-03  6.641407e-03  6.958139e-03  7.288003e-03
## ASV7492      4.600034e-04  5.259225e-04  5.954754e-04  6.687304e-04
## ASV9854     -1.382377e-03 -1.409132e-03 -1.435870e-03 -1.462581e-03
## ASV6296      3.169146e-03  3.245261e-03  3.322306e-03  3.400283e-03
## ASV4201      4.890096e-03  5.148994e-03  5.419563e-03  5.702179e-03
## ASV0552      1.420116e-02  1.472756e-02  1.526785e-02  1.582198e-02
## ASV3671      3.053229e-04  3.304468e-04  3.558519e-04  3.814454e-04
## ASV3529      8.121275e-04  8.689096e-04  9.274921e-04  9.878307e-04
## ASV1060      4.428872e-03  4.642902e-03  4.867269e-03  5.102438e-03
## ASV0239     -4.086224e-03 -4.156739e-03 -4.225901e-03 -4.293577e-03
## ASV5711     -4.925904e-03 -5.070379e-03 -5.217802e-03 -5.368192e-03
## ASV4152     -7.617965e-03 -7.862070e-03 -8.111408e-03 -8.365957e-03
## ASV1461      4.913447e-03  5.025707e-03  5.138985e-03  5.253281e-03
## ASV2877      5.101726e-03  5.240265e-03  5.379913e-03  5.520519e-03
## ASV0012      6.494044e-03  6.771426e-03  7.058506e-03  7.355446e-03
## ASV9823      5.437010e-04  5.348031e-04  5.248079e-04  5.137342e-04
## ASV0008      6.791970e-03  7.078961e-03  7.376009e-03  7.683294e-03
## ASV7832     -4.541657e-03 -4.691104e-03 -4.844385e-03 -5.001548e-03
## ASV1915      9.837051e-04  1.015350e-03  1.046803e-03  1.077966e-03
## ASV0055      3.171535e-03  3.256986e-03  3.342314e-03  3.427286e-03
## ASV0032      6.996057e-03  7.206565e-03  7.422339e-03  7.643583e-03
## ASV2977     -6.316359e-03 -6.513587e-03 -6.714646e-03 -6.919492e-03
## ASV0466      5.047301e-03  5.164205e-03  5.281152e-03  5.398000e-03
## ASV3866      8.897130e-03  9.259765e-03  9.636359e-03  1.002743e-02
## ASV0040      1.251908e-02  1.301876e-02  1.353457e-02  1.406676e-02
## ASV0496     -2.938743e-03 -3.103406e-03 -3.275333e-03 -3.454705e-03
## ASV0052      1.089637e-02  1.122764e-02  1.156513e-02  1.190880e-02
## ASV3828     -7.116638e-03 -7.375935e-03 -7.644126e-03 -7.921519e-03
## ASV1930      4.328364e-03  4.456297e-03  4.586239e-03  4.718162e-03
## ASV2126      7.149737e-03  7.380159e-03  7.615672e-03  7.856282e-03
## ASV0793      7.130453e-03  7.440681e-03  7.762130e-03  8.095075e-03
## ASV0299     -1.592606e-03 -1.637443e-03 -1.685117e-03 -1.735904e-03
## ASV0208      9.929791e-03  1.036809e-02  1.082388e-02  1.129769e-02
## ASV0511     -9.879108e-04 -9.620609e-04 -9.339492e-04 -9.035954e-04
## ASV1123     -2.960413e-03 -3.011923e-03 -3.062387e-03 -3.111669e-03
## ASV0099     -1.233532e-03 -1.200698e-03 -1.161325e-03 -1.114958e-03
## ASV0752     -1.415894e-03 -1.480590e-03 -1.547596e-03 -1.616963e-03
## ASV0883      6.666782e-04  7.018407e-04  7.383552e-04  7.762453e-04
## ASV0683      8.263260e-03  8.599912e-03  8.947727e-03  9.306870e-03
## ASV4117     -7.126091e-03 -7.374958e-03 -7.631072e-03 -7.894573e-03
## ASV2172      3.066841e-03  3.182736e-03  3.302423e-03  3.425993e-03
## ASV0330     -5.501390e-03 -5.701232e-03 -5.907127e-03 -6.119233e-03
## ASV0728      6.219085e-03  6.465067e-03  6.719157e-03  6.981554e-03
## ASV0499      1.305736e-02  1.361871e-02  1.420102e-02  1.480479e-02
## ASV0120     -1.005992e-02 -1.037261e-02 -1.069083e-02 -1.101447e-02
## ASV1446     -1.104869e-03 -1.210251e-03 -1.323004e-03 -1.443531e-03
## ASV17171    -7.115097e-03 -7.377258e-03 -7.647981e-03 -7.927482e-03
## ASV0533      3.135031e-03  3.277459e-03  3.425402e-03  3.578976e-03
## ASV2495     -4.260094e-03 -4.454948e-03 -4.657454e-03 -4.867779e-03
## ASV5582      1.057401e-03  1.058416e-03  1.057827e-03  1.055533e-03
## ASV1488      2.978058e-03  3.090124e-03  3.205009e-03  3.322693e-03
## ASV0682      8.844217e-03  9.210740e-03  9.589733e-03  9.981403e-03
## ASV0068     -1.889730e-03 -1.976134e-03 -2.064389e-03 -2.154369e-03
## ASV1987     -6.096432e-03 -6.381235e-03 -6.677805e-03 -6.986499e-03
## ASV0035     -2.938979e-03 -3.195120e-03 -3.468162e-03 -3.758909e-03
## ASV7192     -3.154044e-03 -3.215939e-03 -3.276929e-03 -3.336889e-03
## ASV0873     -3.709859e-04 -3.982162e-04 -4.261122e-04 -4.546246e-04
## ASV4749     -2.728037e-03 -2.911764e-03 -3.104939e-03 -3.307871e-03
## ASV2174      2.996249e-03  3.082697e-03  3.172488e-03  3.265874e-03
## ASV1476     -4.815629e-03 -5.013187e-03 -5.217627e-03 -5.429090e-03
## ASV0740     -1.247849e-02 -1.298915e-02 -1.351736e-02 -1.406348e-02
## ASV0170      2.286029e-03  2.375268e-03  2.467646e-03  2.563264e-03
## ASV2466     -9.539867e-03 -9.911104e-03 -1.029533e-02 -1.069289e-02
## ASV1709      6.332360e-03  6.537190e-03  6.746551e-03  6.960445e-03
## ASV6170     -7.173552e-03 -7.443044e-03 -7.720501e-03 -8.006025e-03
## ASV3673      8.336048e-03  8.653089e-03  8.979739e-03  9.316136e-03
## ASV1745      5.824326e-04  5.983181e-04  6.140163e-04  6.294596e-04
##                                                                    
## (Intercept) -9.088748e-03 -9.709677e-03 -1.036243e-02 -1.104796e-02
## ASV1236      4.383135e-03  4.498575e-03  4.615885e-03  4.735081e-03
## ASV0421     -8.084560e-03 -8.301151e-03 -8.521406e-03 -8.745367e-03
## ASV0691     -5.610317e-03 -5.738944e-03 -5.869332e-03 -6.001494e-03
## ASV0899      5.202261e-04  5.334174e-04  5.462898e-04  5.588369e-04
## ASV1004      8.982238e-03  9.205864e-03  9.431777e-03  9.659916e-03
## ASV1041     -5.784987e-03 -5.912542e-03 -6.040352e-03 -6.168353e-03
## ASV1058      8.896377e-03  9.147818e-03  9.404034e-03  9.665055e-03
## ASV12542     1.970881e-03  2.015554e-03  2.061081e-03  2.107498e-03
## ASV1294      1.114774e-02  1.147761e-02  1.181416e-02  1.215747e-02
## ASV13113     6.926703e-03  7.232788e-03  7.550923e-03  7.881462e-03
## ASV1318      8.813526e-03  9.049664e-03  9.289462e-03  9.532923e-03
## ASV2269     -2.534052e-03 -2.596379e-03 -2.659337e-03 -2.722916e-03
## ASV2542      9.135490e-03  9.493419e-03  9.862822e-03  1.024389e-02
## ASV2660     -4.474641e-03 -4.582441e-03 -4.691651e-03 -4.802286e-03
## ASV2737     -6.764994e-04 -6.977193e-04 -7.190972e-04 -7.406132e-04
## ASV2840      5.299014e-03  5.399919e-03  5.500546e-03  5.600852e-03
## ASV3053      3.366365e-04  3.515826e-04  3.672993e-04  3.838124e-04
## ASV3077      2.101231e-03  2.164329e-03  2.228991e-03  2.295242e-03
## ASV3134      1.330810e-02  1.388384e-02  1.448172e-02  1.510236e-02
## ASV3140      4.555796e-03  4.711480e-03  4.870853e-03  5.033918e-03
## ASV3579      3.824303e-03  4.003722e-03  4.189260e-03  4.380943e-03
## ASV6119     -2.533836e-03 -2.596393e-03 -2.659597e-03 -2.723429e-03
## ASV7557     -2.533975e-03 -2.596574e-03 -2.659820e-03 -2.723694e-03
## ASV8422      1.235691e-03  1.270613e-03  1.306462e-03  1.343269e-03
## ASV1086     -6.872057e-04 -7.112327e-04 -7.361802e-04 -7.620820e-04
## ASV1310      5.176537e-03  5.301257e-03  5.425868e-03  5.550190e-03
## ASV15750    -8.556783e-04 -8.642420e-04 -8.720919e-04 -8.791764e-04
## ASV16905    -2.535123e-03 -2.597909e-03 -2.661344e-03 -2.725404e-03
## ASV2033      8.015258e-03  8.315897e-03  8.625076e-03  8.942921e-03
## ASV2089      1.742428e-03  1.783666e-03  1.825138e-03  1.866814e-03
## ASV2127      7.562003e-03  7.774852e-03  7.991207e-03  8.211035e-03
## ASV2725      6.958415e-03  7.116132e-03  7.275208e-03  7.435645e-03
## ASV2804     -2.536076e-03 -2.598970e-03 -2.662509e-03 -2.726667e-03
## ASV3075      7.019279e-03  7.291145e-03  7.572751e-03  7.864366e-03
## ASV3327      7.698597e-03  7.995054e-03  8.300774e-03  8.615935e-03
## ASV3342      7.384253e-03  7.647152e-03  7.917373e-03  8.195015e-03
## ASV3532     -7.018366e-03 -7.296651e-03 -7.585410e-03 -7.885009e-03
## ASV3600      8.264803e-03  8.555828e-03  8.854668e-03  9.161411e-03
## ASV4013      5.419827e-03  5.566734e-03  5.715241e-03  5.865264e-03
## ASV4136      4.937726e-03  5.077609e-03  5.220403e-03  5.366138e-03
## ASV4195      2.537309e-03  2.600311e-03  2.663948e-03  2.728193e-03
## ASV4407     -2.537613e-03 -2.600631e-03 -2.664282e-03 -2.728536e-03
## ASV4717     -1.874568e-04 -1.929584e-04 -1.981629e-04 -2.030255e-04
## ASV6794      2.419365e-03  2.492717e-03  2.568309e-03  2.646219e-03
## ASV8324     -2.538629e-03 -2.601725e-03 -2.665448e-03 -2.729770e-03
## ASV8981      5.880957e-04  6.465129e-04  7.079950e-04  7.726054e-04
## ASV9859      5.441883e-03  5.723278e-03  6.018057e-03  6.326742e-03
## ASV0936     -4.543553e-03 -4.678621e-03 -4.816447e-03 -4.957057e-03
## ASV12683    -7.156875e-04 -7.357897e-04 -7.558784e-04 -7.759107e-04
## ASV1293      5.962927e-03  6.123286e-03  6.286342e-03  6.452113e-03
## ASV13055    -1.426648e-04 -1.288534e-04 -1.137393e-04 -9.725314e-05
## ASV17063    -2.539868e-03 -2.602960e-03 -2.666658e-03 -2.730934e-03
## ASV2228      2.540037e-03  2.603125e-03  2.666818e-03  2.731087e-03
## ASV2769      3.066134e-04  3.279110e-04  3.494483e-04  3.711659e-04
## ASV2803      9.186674e-04  9.422249e-04  9.665140e-04  9.915771e-04
## ASV2896      5.648610e-03  5.913095e-03  6.190384e-03  6.481093e-03
## ASV3062      3.028621e-03  3.171903e-03  3.320328e-03  3.473961e-03
## ASV3107      5.693534e-03  5.904250e-03  6.121284e-03  6.344731e-03
## ASV3265      7.520202e-03  7.708939e-03  7.899665e-03  8.092304e-03
## ASV3666     -5.339999e-04 -5.615336e-04 -5.901783e-04 -6.199473e-04
## ASV4497      1.917542e-03  1.972040e-03  2.027691e-03  2.084524e-03
## ASV6914     -1.223454e-03 -1.263433e-03 -1.304298e-03 -1.346053e-03
## ASV0576     -7.816193e-03 -8.006537e-03 -8.199893e-03 -8.396308e-03
## ASV0673      3.816596e-03  3.941285e-03  4.068297e-03  4.197629e-03
## ASV0772      3.698566e-03  3.831244e-03  3.968005e-03  4.108936e-03
## ASV0862     -1.107704e-03 -1.110716e-03 -1.113124e-03 -1.114967e-03
## ASV0898      4.203536e-03  4.361973e-03  4.524663e-03  4.691653e-03
## ASV0910      8.812456e-03  9.163420e-03  9.525819e-03  9.899897e-03
## ASV0964     -2.784987e-03 -2.843495e-03 -2.902304e-03 -2.961412e-03
## ASV10059     4.762540e-03  4.975194e-03  5.196286e-03  5.426082e-03
## ASV10263    -2.542638e-03 -2.605889e-03 -2.669765e-03 -2.734251e-03
## ASV1088      5.514750e-03  5.767170e-03  6.029769e-03  6.302834e-03
## ASV1101      4.551251e-03  4.647052e-03  4.741646e-03  4.834851e-03
## ASV1183      3.805258e-03  3.933799e-03  4.065709e-03  4.201044e-03
## ASV11956     6.730283e-04  6.885501e-04  7.046769e-04  7.214450e-04
## ASV12774    -8.072482e-04 -8.395622e-04 -8.728487e-04 -9.071249e-04
## ASV1321      3.560920e-03  3.726151e-03  3.897037e-03  4.073627e-03
## ASV13793    -2.543288e-03 -2.606615e-03 -2.670593e-03 -2.735212e-03
## ASV14482    -4.321291e-04 -4.412590e-04 -4.501103e-04 -4.586615e-04
## ASV15483     2.803933e-03  2.909263e-03  3.017903e-03  3.129938e-03
## ASV2062      1.387094e-02  1.430411e-02  1.474637e-02  1.519772e-02
## ASV2132      7.999485e-03  8.296574e-03  8.602174e-03  8.916377e-03
## ASV2413      8.048673e-03  8.290332e-03  8.537387e-03  8.789912e-03
## ASV2490      4.247777e-03  4.345286e-03  4.443657e-03  4.542879e-03
## ASV2594      4.341402e-03  4.534315e-03  4.735570e-03  4.945462e-03
## ASV2822     -2.544369e-03 -2.607869e-03 -2.672056e-03 -2.736928e-03
## ASV2863      4.497698e-03  4.622396e-03  4.749502e-03  4.879050e-03
## ASV2910      5.685212e-03  5.838617e-03  5.994994e-03  6.154411e-03
## ASV2980      1.836021e-03  1.872910e-03  1.909720e-03  1.946441e-03
## ASV3307      2.545309e-03  2.608984e-03  2.673382e-03  2.738505e-03
## ASV3474      7.255197e-03  7.534481e-03  7.821354e-03  8.115814e-03
## ASV3502      1.104685e-02  1.143414e-02  1.183321e-02  1.224437e-02
## ASV4236      3.777771e-03  3.867695e-03  3.958776e-03  4.051025e-03
## ASV4842     -1.364141e-03 -1.392573e-03 -1.420868e-03 -1.449010e-03
## ASV4894     -2.546353e-03 -2.610205e-03 -2.674811e-03 -2.740171e-03
## ASV5290      3.761002e-03  3.867839e-03  3.976198e-03  4.086058e-03
## ASV5501      1.092863e-03  1.146596e-03  1.202851e-03  1.261710e-03
## ASV5795      3.493101e-03  3.622630e-03  3.755551e-03  3.891858e-03
## ASV5987     -2.547493e-03 -2.611537e-03 -2.676361e-03 -2.741968e-03
## ASV6267     -2.547909e-03 -2.612025e-03 -2.676930e-03 -2.742630e-03
## ASV6862      4.280022e-03  4.388709e-03  4.499446e-03  4.612273e-03
## ASV7145      9.691647e-04  1.008290e-03  1.049061e-03  1.091521e-03
## ASV7673     -2.548867e-03 -2.613128e-03 -2.678195e-03 -2.744074e-03
## ASV7789      3.339920e-03  3.510830e-03  3.688852e-03  3.874159e-03
## ASV7809      6.630640e-04  7.070005e-04  7.525434e-04  7.996815e-04
## ASV8002     -2.550273e-03 -2.614755e-03 -2.680069e-03 -2.746220e-03
## ASV8205      2.308665e-03  2.400562e-03  2.495494e-03  2.593505e-03
## ASV9155     -1.757121e-03 -1.795933e-03 -1.834932e-03 -1.874107e-03
## ASV9221      1.109747e-03  1.188345e-03  1.270925e-03  1.357610e-03
## ASV9311     -2.552522e-03 -2.617320e-03 -2.682979e-03 -2.749501e-03
## ASV9557     -2.553166e-03 -2.618048e-03 -2.683797e-03 -2.750415e-03
## ASV9936     -2.553822e-03 -2.618786e-03 -2.684623e-03 -2.751333e-03
## ASV1445      9.048515e-03  9.391495e-03  9.745360e-03  1.011034e-02
## ASV4232      9.872449e-03  1.032390e-02  1.079444e-02  1.128472e-02
## ASV6479      2.205248e-03  2.340958e-03  2.483080e-03  2.631788e-03
## ASV0142     -1.233794e-02 -1.265224e-02 -1.297088e-02 -1.329386e-02
## ASV0378     -2.643944e-03 -2.658312e-03 -2.670011e-03 -2.678959e-03
## ASV1122      1.156357e-02  1.197556e-02  1.239851e-02  1.283252e-02
## ASV0123     -1.195484e-02 -1.225399e-02 -1.255691e-02 -1.286356e-02
## ASV2064      7.337255e-04  7.449427e-04  7.565592e-04  7.686446e-04
## ASV4459     -1.318090e-03 -1.354536e-03 -1.391989e-03 -1.430491e-03
## ASV0448      5.665145e-03  5.920263e-03  6.184485e-03  6.457958e-03
## ASV0397      7.832793e-03  8.094172e-03  8.361862e-03  8.635904e-03
## ASV0485      1.042805e-02  1.078540e-02  1.115298e-02  1.153100e-02
## ASV1566      8.995939e-03  9.291318e-03  9.593733e-03  9.903257e-03
## ASV1365      5.899549e-03  6.084598e-03  6.272856e-03  6.464258e-03
## ASV1065      1.246034e-02  1.288928e-02  1.332927e-02  1.378040e-02
## ASV0722     -1.739228e-04 -1.897281e-04 -2.070874e-04 -2.261157e-04
## ASV12660    -3.894807e-03 -3.990424e-03 -4.087292e-03 -4.185413e-03
## ASV0223      3.232486e-04  3.588974e-04  3.971874e-04  4.382382e-04
## ASV0229      6.678053e-03  6.943132e-03  7.217276e-03  7.500708e-03
## ASV0877     -9.779439e-04 -9.991120e-04 -1.021128e-03 -1.044065e-03
## ASV0983      9.473392e-03  9.755210e-03  1.004255e-02  1.033541e-02
## ASV0626     -9.593686e-04 -9.504980e-04 -9.409038e-04 -9.306448e-04
## ASV4146     -7.084493e-04 -7.557247e-04 -8.068602e-04 -8.621303e-04
## ASV4175     -6.590144e-03 -6.799686e-03 -7.013557e-03 -7.231733e-03
## ASV2082     -2.526905e-03 -2.673321e-03 -2.826476e-03 -2.986543e-03
## ASV2272      6.027305e-03  6.259552e-03  6.498768e-03  6.745036e-03
## ASV2245     -6.248417e-03 -6.467583e-03 -6.692925e-03 -6.924556e-03
## ASV0590     -6.158713e-03 -6.428670e-03 -6.708338e-03 -6.997950e-03
## ASV0217      4.921882e-04  6.340057e-04  7.838705e-04  9.419520e-04
## ASV0416      2.439220e-03  2.449163e-03  2.455956e-03  2.459402e-03
## ASV1056      8.692847e-03  9.016413e-03  9.348330e-03  9.688626e-03
## ASV7777     -6.291047e-03 -6.530168e-03 -6.778049e-03 -7.035035e-03
## ASV0455      1.450747e-03  1.487142e-03  1.522876e-03  1.557819e-03
## ASV0604      3.170775e-03  3.316153e-03  3.466743e-03  3.622663e-03
## ASV6100     -6.082975e-03 -6.322115e-03 -6.570250e-03 -6.827709e-03
## ASV11359    -5.511087e-03 -5.675105e-03 -5.841877e-03 -6.011353e-03
## ASV6604      5.508594e-03  5.727591e-03  5.953686e-03  6.187002e-03
## ASV5004     -3.467645e-03 -3.591466e-03 -3.719482e-03 -3.851836e-03
## ASV1483     -3.279782e-03 -3.391022e-03 -3.505063e-03 -3.621911e-03
## ASV9773     -7.438975e-03 -7.714974e-03 -8.000125e-03 -8.294690e-03
## ASV4059      2.063721e-03  2.164074e-03  2.267827e-03  2.374979e-03
## ASV1193      1.112428e-02  1.149018e-02  1.186453e-02  1.224734e-02
## ASV4610      7.145551e-04  7.538259e-04  7.932585e-04  8.327230e-04
## ASV0742     -1.121815e-03 -1.107400e-03 -1.091759e-03 -1.074948e-03
## ASV1502     -1.117529e-03 -1.175108e-03 -1.234643e-03 -1.296134e-03
## ASV0195     -2.477979e-03 -2.589105e-03 -2.704517e-03 -2.824363e-03
## ASV1213      1.707717e-03  1.717540e-03  1.725285e-03  1.730823e-03
## ASV1648     -5.542710e-03 -5.758678e-03 -5.982842e-03 -6.215502e-03
## ASV6984     -4.601592e-03 -4.794837e-03 -4.996118e-03 -5.205753e-03
## ASV0396      1.435419e-03  1.558268e-03  1.685461e-03  1.816905e-03
## ASV4297      4.084524e-03  4.188713e-03  4.294462e-03  4.401777e-03
## ASV2622      1.049225e-02  1.079643e-02  1.110717e-02  1.142461e-02
## ASV3512      4.959016e-03  5.223184e-03  5.500081e-03  5.790211e-03
## ASV2411      6.082378e-03  6.314519e-03  6.552486e-03  6.796176e-03
## ASV2291     -2.694971e-03 -2.824253e-03 -2.958360e-03 -3.097372e-03
## ASV0807      8.398988e-03  8.739968e-03  9.091303e-03  9.453114e-03
## ASV1292      2.678000e-03  2.774367e-03  2.874263e-03  2.977817e-03
## ASV1035      9.317071e-04  9.654294e-04  1.000683e-03  1.037534e-03
## ASV0070      4.678644e-04  5.837483e-04  7.075697e-04  8.396112e-04
## ASV0255      4.730596e-04  4.351857e-04  3.915337e-04  3.416638e-04
## ASV0057     -7.594375e-03 -7.692875e-03 -7.786187e-03 -7.873945e-03
## ASV0077      7.105366e-04  7.863012e-04  8.646964e-04  9.455770e-04
## ASV0625      9.575877e-03  9.801290e-03  1.002798e-02  1.025579e-02
## ASV2464      4.334303e-03  4.438281e-03  4.543502e-03  4.649958e-03
## ASV1315      1.518164e-02  1.576859e-02  1.637280e-02  1.699439e-02
## ASV2673      1.247486e-02  1.301896e-02  1.358424e-02  1.417130e-02
## ASV2161      5.382354e-03  5.620164e-03  5.867048e-03  6.123226e-03
## ASV0337     -4.858435e-03 -4.998808e-03 -5.141723e-03 -5.287184e-03
## ASV7680     -7.223237e-03 -7.483460e-03 -7.751099e-03 -8.026242e-03
## ASV0611      1.837555e-02  1.912128e-02  1.989316e-02  2.069184e-02
## ASV3118     -5.665362e-03 -5.872492e-03 -6.085413e-03 -6.304180e-03
## ASV1284      6.031768e-03  6.249495e-03  6.472657e-03  6.701226e-03
## ASV0889      3.879829e-03  4.025032e-03  4.175692e-03  4.332030e-03
## ASV4649     -4.174490e-03 -4.317090e-03 -4.463424e-03 -4.613531e-03
## ASV1108     -7.788724e-03 -8.119642e-03 -8.462197e-03 -8.816615e-03
## ASV0738      4.553859e-03  4.853154e-03  5.167889e-03  5.498644e-03
## ASV0473      1.170192e-03  1.222194e-03  1.276328e-03  1.332690e-03
## ASV0598     -3.206912e-03 -3.249903e-03 -3.290976e-03 -3.329974e-03
## ASV0429      8.163331e-03  8.398258e-03  8.637366e-03  8.880671e-03
## ASV1549      1.382153e-02  1.439502e-02  1.498720e-02  1.559827e-02
## ASV1203      6.653082e-03  6.852977e-03  7.056115e-03  7.262401e-03
## ASV4532      2.661184e-04  2.951736e-04  3.272067e-04  3.624404e-04
## ASV0274     -4.372101e-03 -4.466488e-03 -4.562131e-03 -4.659110e-03
## ASV0163     -5.820019e-03 -5.923769e-03 -6.027087e-03 -6.129925e-03
## ASV1298      2.910823e-03  3.004785e-03  3.102736e-03  3.204929e-03
## ASV9424     -1.045948e-02 -1.086818e-02 -1.129085e-02 -1.172787e-02
## ASV0412      1.245180e-02  1.284022e-02  1.323677e-02  1.364145e-02
## ASV0284      3.781791e-03  3.847508e-03  3.911316e-03  3.972967e-03
## ASV0620     -6.364016e-03 -6.617127e-03 -6.878198e-03 -7.147366e-03
## ASV0153     -1.157417e-02 -1.199404e-02 -1.242390e-02 -1.286362e-02
## ASV0498      3.916367e-03  4.079570e-03  4.245725e-03  4.414613e-03
## ASV0097      9.678575e-03  1.008929e-02  1.051461e-02  1.095486e-02
## ASV0104     -2.980975e-02 -3.076324e-02 -3.173789e-02 -3.273376e-02
## ASV1282      5.646412e-03  5.819972e-03  5.995695e-03  6.173399e-03
## ASV3883     -3.915493e-03 -4.045105e-03 -4.176334e-03 -4.308991e-03
## ASV0801      5.067686e-03  5.291986e-03  5.525114e-03  5.767347e-03
## ASV1611     -1.394291e-02 -1.446338e-02 -1.499938e-02 -1.555114e-02
## ASV0227     -7.099899e-03 -7.409012e-03 -7.729731e-03 -8.062401e-03
## ASV0833      7.150348e-03  7.436891e-03  7.731958e-03  8.035625e-03
## ASV0718      1.160778e-02  1.199543e-02  1.239171e-02  1.279657e-02
## ASV1139      7.547373e-04  6.907667e-04  6.210245e-04  5.453134e-04
## ASV0766     -2.286001e-03 -2.349902e-03 -2.415268e-03 -2.482138e-03
## ASV2091      1.059381e-02  1.085509e-02  1.111959e-02  1.138731e-02
## ASV1238      1.486681e-03  1.582980e-03  1.682615e-03  1.785541e-03
## ASV9193     -3.400751e-03 -3.551445e-03 -3.706425e-03 -3.865644e-03
## ASV0290     -1.911684e-03 -1.956954e-03 -2.000463e-03 -2.041964e-03
## ASV0231      1.126005e-02  1.161459e-02  1.197619e-02  1.234480e-02
## ASV0185      1.119307e-02  1.183091e-02  1.249891e-02  1.319807e-02
## ASV2330      2.663933e-03  2.743993e-03  2.826364e-03  2.911136e-03
## ASV3119     -7.534226e-03 -7.887107e-03 -8.254015e-03 -8.635331e-03
## ASV2368     -8.023412e-03 -8.386440e-03 -8.764588e-03 -9.158349e-03
## ASV0122     -2.789507e-03 -2.861190e-03 -2.934941e-03 -3.010931e-03
## ASV1044      1.146442e-02  1.195683e-02  1.246695e-02  1.299518e-02
## ASV0160     -5.506752e-03 -5.589141e-03 -5.670555e-03 -5.750997e-03
## ASV0326      6.745319e-03  6.954096e-03  7.166214e-03  7.381539e-03
## ASV1388      1.175386e-02  1.214923e-02  1.255489e-02  1.297099e-02
## ASV0792      1.098304e-02  1.127534e-02  1.157098e-02  1.186984e-02
## ASV0036     -9.623285e-03 -9.940011e-03 -1.026173e-02 -1.058813e-02
## ASV2125      1.320107e-02  1.360702e-02  1.402007e-02  1.444005e-02
## ASV1075      3.875127e-03  4.039164e-03  4.209029e-03  4.384850e-03
## ASV0390      6.195499e-03  6.525192e-03  6.870818e-03  7.232986e-03
## ASV3790     -1.258865e-02 -1.304735e-02 -1.351933e-02 -1.400479e-02
## ASV1535     -2.219770e-03 -2.324482e-03 -2.432621e-03 -2.544176e-03
## ASV0263      2.547468e-03  2.641673e-03  2.738873e-03  2.839144e-03
## ASV0675      2.422395e-02  2.518594e-02  2.617846e-02  2.720194e-02
## ASV3348      3.319372e-03  3.478022e-03  3.643304e-03  3.815414e-03
## ASV0058     -1.554777e-02 -1.599285e-02 -1.644434e-02 -1.690207e-02
## ASV4142      3.646835e-03  3.752923e-03  3.861450e-03  3.972484e-03
## ASV0059     -1.292382e-02 -1.327558e-02 -1.363118e-02 -1.399040e-02
## ASV0013     -3.054149e-02 -3.153498e-02 -3.255188e-02 -3.359240e-02
## ASV0033     -1.103306e-02 -1.142249e-02 -1.182051e-02 -1.222697e-02
## ASV4354     -3.496005e-03 -3.609846e-03 -3.726519e-03 -3.846018e-03
## ASV0022     -1.122339e-02 -1.160096e-02 -1.198519e-02 -1.237576e-02
## ASV0134     -4.185877e-03 -4.385848e-03 -4.595312e-03 -4.814728e-03
## ASV0415      4.684690e-04  5.313370e-04  5.972505e-04  6.662620e-04
## ASV10103    -7.622838e-03 -7.890732e-03 -8.165293e-03 -8.446526e-03
## ASV1613      8.699159e-03  8.913903e-03  9.129685e-03  9.346320e-03
## ASV0135      4.012270e-03  4.281992e-03  4.565818e-03  4.864247e-03
## ASV0469     -1.156288e-02 -1.191018e-02 -1.226534e-02 -1.262849e-02
## ASV0471      9.500055e-03  9.853201e-03  1.021838e-02  1.059599e-02
## ASV0451     -4.242053e-03 -4.424327e-03 -4.612433e-03 -4.806422e-03
## ASV0747      5.214741e-03  5.416737e-03  5.623843e-03  5.836027e-03
## ASV1314     -9.103730e-03 -9.543231e-03 -1.000221e-02 -1.048136e-02
## ASV0425     -1.052063e-02 -1.075733e-02 -1.099587e-02 -1.123621e-02
## ASV0559     -7.342802e-03 -7.598536e-03 -7.863835e-03 -8.139080e-03
## ASV0148     -5.356761e-03 -5.413940e-03 -5.466209e-03 -5.513232e-03
## ASV0129     -7.118934e-05  5.346004e-05  1.871142e-04  3.300461e-04
## ASV1072      2.253966e-03  2.271259e-03  2.287105e-03  2.301534e-03
## ASV2390      1.385636e-03  1.378019e-03  1.367870e-03  1.355116e-03
## ASV0548      1.115755e-02  1.155626e-02  1.196606e-02  1.238708e-02
## ASV0168     -1.342365e-02 -1.384577e-02 -1.427849e-02 -1.472202e-02
## ASV0066     -9.813987e-03 -1.008368e-02 -1.035587e-02 -1.063030e-02
## ASV0468     -4.624973e-03 -4.809011e-03 -5.000427e-03 -5.199534e-03
## ASV0172      1.845687e-03  2.013497e-03  2.190217e-03  2.376085e-03
## ASV0236     -2.939389e-04 -1.751013e-04 -4.858985e-05  8.570833e-05
## ASV0250      7.567447e-03  8.029031e-03  8.513098e-03  9.020367e-03
## ASV0338      1.676016e-03  1.769644e-03  1.866173e-03  1.965589e-03
## ASV0450     -2.025342e-04 -2.273218e-04 -2.546608e-04 -2.847338e-04
## ASV0377      1.208664e-02  1.246337e-02  1.284657e-02  1.323603e-02
## ASV1022      4.231149e-03  4.406421e-03  4.588465e-03  4.777505e-03
## ASV6174     -8.363218e-04 -8.652615e-04 -8.944191e-04 -9.236774e-04
## ASV0786      6.411195e-04  6.491958e-04  6.571445e-04  6.649753e-04
## ASV0053     -1.513375e-02 -1.563464e-02 -1.614706e-02 -1.667102e-02
## ASV0697     -2.260559e-03 -2.291407e-03 -2.321645e-03 -2.351308e-03
## ASV0785      1.132959e-02  1.172651e-02  1.213568e-02  1.255748e-02
## ASV1967     -5.355136e-03 -5.496614e-03 -5.640300e-03 -5.786183e-03
## ASV0385     -1.639178e-03 -1.661976e-03 -1.684753e-03 -1.707551e-03
## ASV0295      4.089855e-03  4.345880e-03  4.614456e-03  4.895956e-03
## ASV0072     -7.558200e-03 -7.683645e-03 -7.805768e-03 -7.924308e-03
## ASV0157     -5.088362e-04 -3.688081e-04 -2.151786e-04 -4.720448e-05
## ASV0501      8.035313e-03  8.362580e-03  8.699900e-03  9.047371e-03
## ASV10729    -9.928067e-03 -1.027175e-02 -1.062389e-02 -1.098451e-02
## ASV1470      3.033274e-03  3.092307e-03  3.150176e-03  3.206716e-03
## ASV0050     -2.658952e-02 -2.738203e-02 -2.818896e-02 -2.901019e-02
## ASV0411      8.085131e-04  8.623644e-04  9.170936e-04  9.724712e-04
## ASV0549      8.326186e-03  8.683289e-03  9.053382e-03  9.436746e-03
## ASV0184      4.051739e-03  4.215687e-03  4.385582e-03  4.561573e-03
## ASV0705      4.679779e-03  4.828066e-03  4.978396e-03  5.130622e-03
## ASV1715      1.144938e-02  1.185720e-02  1.227642e-02  1.270721e-02
## ASV0603      2.523368e-03  2.663625e-03  2.811330e-03  2.966792e-03
## ASV0826      2.229030e-03  2.271641e-03  2.313857e-03  2.355611e-03
## ASV0034     -1.011894e-02 -1.035393e-02 -1.058937e-02 -1.082507e-02
## ASV0838      1.688819e-03  1.689150e-03  1.685292e-03  1.676942e-03
## ASV0614     -6.355294e-03 -6.524567e-03 -6.695379e-03 -6.867598e-03
## ASV0014     -2.646347e-02 -2.728132e-02 -2.811624e-02 -2.896826e-02
## ASV0585     -1.874403e-03 -1.924866e-03 -1.975138e-03 -2.025107e-03
## ASV0016     -2.730376e-02 -2.815515e-02 -2.902472e-02 -2.991255e-02
## ASV5394     -7.710092e-03 -7.948437e-03 -8.189518e-03 -8.432978e-03
## ASV0666      5.642236e-03  5.807622e-03  5.975945e-03  6.147201e-03
## ASV2085     -8.940424e-04 -9.973302e-04 -1.106149e-03 -1.220659e-03
## ASV0003     -2.431463e-02 -2.505919e-02 -2.581942e-02 -2.659540e-02
## ASV0346      2.957517e-03  3.126830e-03  3.302640e-03  3.485036e-03
## ASV0267     -1.788598e-03 -1.800843e-03 -1.812953e-03 -1.825104e-03
## ASV0353      1.011217e-02  1.056346e-02  1.103105e-02  1.151522e-02
## ASV2419      6.578036e-03  6.770855e-03  6.966751e-03  7.165616e-03
## ASV0447      7.521561e-03  7.858122e-03  8.206565e-03  8.567143e-03
## ASV0654      1.277454e-02  1.319497e-02  1.362412e-02  1.406198e-02
## ASV0151      5.472665e-03  5.767400e-03  6.075508e-03  6.397391e-03
## ASV0065     -9.683873e-03 -9.960594e-03 -1.024136e-02 -1.052609e-02
## ASV0527      7.454834e-03  7.686301e-03  7.922258e-03  8.162669e-03
## ASV4055     -5.106257e-03 -5.366651e-03 -5.640352e-03 -5.928011e-03
## ASV0166     -6.549962e-03 -6.711762e-03 -6.875572e-03 -7.041408e-03
## ASV0417     -6.781382e-03 -6.994311e-03 -7.212496e-03 -7.436047e-03
## ASV0078     -3.222984e-03 -3.225249e-03 -3.221017e-03 -3.209881e-03
## ASV0322     -4.623478e-03 -4.698870e-03 -4.772634e-03 -4.844678e-03
## ASV0156     -8.290353e-03 -8.544807e-03 -8.805552e-03 -9.072749e-03
## ASV0648     -1.044982e-02 -1.084142e-02 -1.124465e-02 -1.165969e-02
## ASV0407      1.997626e-03  2.102534e-03  2.212101e-03  2.326464e-03
## ASV2030     -1.458755e-03 -1.526778e-03 -1.598811e-03 -1.675062e-03
## ASV0300      8.147183e-03  8.480047e-03  8.822640e-03  9.174967e-03
## ASV1150      6.739191e-04  7.299777e-04  7.884788e-04  8.493946e-04
## ASV0958      9.988103e-03  1.048129e-02  1.099662e-02  1.153485e-02
## ASV0216     -7.347916e-03 -7.589939e-03 -7.840618e-03 -8.100356e-03
## ASV0446      1.698546e-02  1.763584e-02  1.830478e-02  1.899243e-02
## ASV0367     -4.255017e-03 -4.398756e-03 -4.546494e-03 -4.698310e-03
## ASV0200     -8.752036e-03 -9.065450e-03 -9.387910e-03 -9.719556e-03
## ASV0334     -2.191911e-04 -1.548613e-04 -8.743484e-05 -1.696812e-05
## ASV1311      4.781365e-03  4.906815e-03  5.033160e-03  5.160259e-03
## ASV0458      6.168788e-03  6.378680e-03  6.594106e-03  6.815139e-03
## ASV1371      3.264598e-04  3.373206e-04  3.481910e-04  3.590416e-04
## ASV0418      8.279620e-03  8.586311e-03  8.902802e-03  9.229330e-03
## ASV0004      8.716459e-03  8.991836e-03  9.272760e-03  9.559181e-03
## ASV1943      5.761790e-03  5.938272e-03  6.118477e-03  6.302425e-03
## ASV1495     -4.721288e-03 -4.971234e-03 -5.232399e-03 -5.505118e-03
## ASV0901     -1.345991e-02 -1.400905e-02 -1.457763e-02 -1.516615e-02
## ASV0628      3.891031e-03  3.937499e-03  3.979175e-03  4.015598e-03
## ASV0400      1.428985e-03  1.430089e-03  1.427314e-03  1.420302e-03
## ASV0116     -1.143459e-02 -1.191170e-02 -1.240523e-02 -1.291548e-02
## ASV0788      6.847759e-03  7.079277e-03  7.316504e-03  7.559515e-03
## ASV0117      7.083207e-03  7.403914e-03  7.736983e-03  8.082716e-03
## ASV3137      1.013305e-03  1.053312e-03  1.095645e-03  1.140509e-03
## ASV0001      7.381433e-03  7.544240e-03  7.707868e-03  7.872284e-03
## ASV1651      5.631885e-03  5.806181e-03  5.986147e-03  6.172080e-03
## ASV1692      1.084547e-02  1.129200e-02  1.175407e-02  1.223207e-02
## ASV0660      9.105989e-04  8.241907e-04  7.289000e-04  6.243255e-04
## ASV0508     -1.127128e-04 -1.294526e-04 -1.475929e-04 -1.672685e-04
## ASV1660     -4.579429e-03 -4.752448e-03 -4.929609e-03 -5.110834e-03
## ASV0233      3.415552e-03  3.588566e-03  3.769704e-03  3.959286e-03
## ASV1343     -9.146842e-03 -9.498593e-03 -9.862088e-03 -1.023764e-02
## ASV0209      4.860347e-03  4.975513e-03  5.091934e-03  5.209592e-03
## ASV0193     -7.529334e-03 -7.746157e-03 -7.967535e-03 -8.193535e-03
## ASV0357      2.880133e-03  3.093210e-03  3.318815e-03  3.557487e-03
## ASV0198      2.722141e-03  2.844984e-03  2.973070e-03  3.106559e-03
## ASV0007      7.014901e-03  7.170208e-03  7.326330e-03  7.483237e-03
## ASV1772     -3.550322e-06  6.123181e-05  1.336978e-04  2.144602e-04
## ASV0009      6.441509e-03  6.579488e-03  6.718057e-03  6.857206e-03
## ASV0006      4.606571e-04  4.007928e-04  3.370413e-04  2.693809e-04
## ASV0011     -1.316547e-02 -1.366610e-02 -1.418199e-02 -1.471335e-02
## ASV0015      7.236786e-03  7.454343e-03  7.675113e-03  7.898941e-03
## ASV0017      7.661624e-03  7.897128e-03  8.136691e-03  8.380194e-03
## ASV0235     -7.246085e-03 -7.510730e-03 -7.783505e-03 -8.064634e-03
## ASV0382      3.443819e-03  3.565355e-03  3.686679e-03  3.807372e-03
## ASV2357      1.121584e-02  1.164647e-02  1.209111e-02  1.255000e-02
## ASV0567     -7.044766e-03 -7.313289e-03 -7.591721e-03 -7.880372e-03
## ASV0165      7.744258e-03  8.006403e-03  8.275560e-03  8.551873e-03
## ASV0005      1.264832e-02  1.297695e-02  1.330844e-02  1.364255e-02
## ASV0384      2.537469e-03  2.745645e-03  2.967433e-03  3.203511e-03
## ASV0002      5.453538e-03  5.694673e-03  5.944324e-03  6.202607e-03
## ASV3017      7.122012e-03  7.319415e-03  7.520376e-03  7.724919e-03
## ASV0091      4.363369e-03  4.519256e-03  4.678217e-03  4.840098e-03
## ASV0186     -9.737302e-03 -1.004393e-02 -1.035534e-02 -1.067132e-02
## ASV0370      1.898023e-03  2.001775e-03  2.111028e-03  2.226015e-03
## ASV0018      1.376011e-02  1.414124e-02  1.452747e-02  1.491869e-02
## ASV1377      1.225373e-02  1.262003e-02  1.299373e-02  1.337489e-02
## ASV0019      1.389503e-02  1.428519e-02  1.468101e-02  1.508240e-02
## ASV0023     -2.142744e-03 -2.279855e-03 -2.422005e-03 -2.569173e-03
## ASV2194      7.166682e-03  7.463908e-03  7.771498e-03  8.089659e-03
## ASV1155      1.192794e-03  1.273323e-03  1.357355e-03  1.444967e-03
## ASV0510     -2.394837e-03 -2.409569e-03 -2.423039e-03 -2.435254e-03
## ASV2371     -3.730898e-03 -3.811232e-03 -3.891686e-03 -3.972205e-03
## ASV0024     -2.971673e-03 -3.138619e-03 -3.311519e-03 -3.490379e-03
## ASV2452      4.755676e-03  4.844234e-03  4.932390e-03  5.020117e-03
## ASV2332      3.085521e-03  3.239752e-03  3.399405e-03  3.564530e-03
## ASV2591      2.786445e-03  2.917375e-03  3.052307e-03  3.191242e-03
## ASV0521      1.388978e-02  1.445633e-02  1.504262e-02  1.564914e-02
## ASV5542      4.472328e-03  4.645362e-03  4.823647e-03  5.007270e-03
## ASV0336     -4.855040e-03 -5.032440e-03 -5.216503e-03 -5.407556e-03
## ASV10102     8.138543e-03  8.416553e-03  8.700585e-03  8.990561e-03
## ASV16823    -3.482292e-03 -3.562313e-03 -3.643280e-03 -3.725203e-03
## ASV3104      3.481988e-03  3.561980e-03  3.642917e-03  3.724807e-03
## ASV0781      2.357063e-03  2.435497e-03  2.516666e-03  2.600688e-03
## ASV10899     5.755805e-03  6.026086e-03  6.306787e-03  6.598148e-03
## ASV11222    -3.481611e-03 -3.561567e-03 -3.642466e-03 -3.724315e-03
## ASV11327    -3.481327e-03 -3.561258e-03 -3.642130e-03 -3.723951e-03
## ASV12458    -3.481056e-03 -3.560964e-03 -3.641812e-03 -3.723606e-03
## ASV1636     -2.629705e-03 -2.687254e-03 -2.745724e-03 -2.805161e-03
## ASV1890     -4.457976e-03 -4.609187e-03 -4.765895e-03 -4.928345e-03
## ASV2898      1.025926e-02  1.056192e-02  1.087121e-02  1.118726e-02
## ASV8328      2.575018e-03  2.745603e-03  2.924277e-03  3.111238e-03
## ASV0709     -8.472647e-03 -8.715506e-03 -8.962726e-03 -9.214326e-03
## ASV0856      2.892203e-03  3.017587e-03  3.147109e-03  3.280813e-03
## ASV0909      2.211662e-05  1.153965e-04  2.145848e-04  3.198317e-04
## ASV0937     -9.666663e-03 -1.006880e-02 -1.048610e-02 -1.091898e-02
## ASV11390    -3.480300e-03 -3.560146e-03 -3.640929e-03 -3.722655e-03
## ASV11966     4.777013e-03  4.974198e-03  5.177538e-03  5.387096e-03
## ASV12990     1.572933e-03  1.624716e-03  1.677882e-03  1.732454e-03
## ASV14797     4.245414e-03  4.358585e-03  4.473997e-03  4.591695e-03
## ASV14904    -3.479876e-03 -3.559688e-03 -3.640434e-03 -3.722124e-03
## ASV15304     3.650215e-03  3.813061e-03  3.981286e-03  4.154947e-03
## ASV16696    -3.479645e-03 -3.559443e-03 -3.640176e-03 -3.721852e-03
## ASV1690      4.832101e-03  5.011072e-03  5.193854e-03  5.380369e-03
## ASV2029      1.450604e-02  1.496660e-02  1.543755e-02  1.591895e-02
## ASV2834      9.135503e-03  9.458893e-03  9.790748e-03  1.013111e-02
## ASV4003      6.352047e-03  6.682677e-03  7.028891e-03  7.391319e-03
## ASV4064      6.914674e-03  7.165245e-03  7.423024e-03  7.688159e-03
## ASV4294      4.972204e-03  5.219444e-03  5.477084e-03  5.745408e-03
## ASV4609      4.800116e-04  5.132707e-04  5.482053e-04  5.848601e-04
## ASV6283     -3.479231e-03 -3.559006e-03 -3.639716e-03 -3.721368e-03
## ASV6491     -3.479130e-03 -3.558902e-03 -3.639610e-03 -3.721261e-03
## ASV7453      4.833194e-03  5.047156e-03  5.268094e-03  5.496065e-03
## ASV7959      2.985946e-03  3.144671e-03  3.310183e-03  3.482678e-03
## ASV8219      3.479014e-03  3.558789e-03  3.639501e-03  3.721158e-03
## ASV8547     -3.478974e-03 -3.558753e-03 -3.639470e-03 -3.721132e-03
## ASV9319      5.299912e-03  5.527706e-03  5.764670e-03  6.011128e-03
## ASV9382     -3.478942e-03 -3.558727e-03 -3.639452e-03 -3.721124e-03
## ASV11516    -3.478950e-03 -3.558744e-03 -3.639479e-03 -3.721162e-03
## ASV14377    -3.478976e-03 -3.558781e-03 -3.639527e-03 -3.721224e-03
## ASV1867      9.748000e-03  1.011202e-02  1.048743e-02  1.087450e-02
## ASV1895     -1.314549e-03 -1.361389e-03 -1.410267e-03 -1.461269e-03
## ASV3168      2.126798e-03  2.158293e-03  2.188931e-03  2.218671e-03
## ASV4449      5.662300e-03  5.842028e-03  6.026950e-03  6.217227e-03
## ASV6596      7.631363e-03  7.988578e-03  8.360005e-03  8.745989e-03
## ASV7492      7.457496e-04  8.265881e-04  9.112939e-04  9.999071e-04
## ASV9854     -1.489255e-03 -1.515884e-03 -1.542461e-03 -1.568982e-03
## ASV6296      3.479197e-03  3.559052e-03  3.639856e-03  3.721617e-03
## ASV4201      5.997226e-03  6.305087e-03  6.626152e-03  6.960814e-03
## ASV0552      1.638990e-02  1.697152e-02  1.756673e-02  1.817539e-02
## ASV3671      4.071275e-04  4.327919e-04  4.583257e-04  4.836097e-04
## ASV3529      1.049874e-03  1.113566e-03  1.178842e-03  1.245631e-03
## ASV1060      5.348890e-03  5.607125e-03  5.877655e-03  6.161013e-03
## ASV0239     -4.359630e-03 -4.423917e-03 -4.486296e-03 -4.546620e-03
## ASV5711     -5.521561e-03 -5.677924e-03 -5.837291e-03 -5.999673e-03
## ASV4152     -8.625689e-03 -8.890570e-03 -9.160561e-03 -9.435616e-03
## ASV1461      5.368595e-03  5.484930e-03  5.602287e-03  5.720670e-03
## ASV2877      5.661924e-03  5.803960e-03  5.946452e-03  6.089218e-03
## ASV0012      7.662398e-03  7.979504e-03  8.306895e-03  8.644691e-03
## ASV9823      5.016086e-04  4.884650e-04  4.743451e-04  4.592982e-04
## ASV0008      8.000984e-03  8.329240e-03  8.668213e-03  9.018040e-03
## ASV7832     -5.162643e-03 -5.327716e-03 -5.496810e-03 -5.669969e-03
## ASV1915      1.108733e-03  1.138998e-03  1.168647e-03  1.197567e-03
## ASV0055      3.511655e-03  3.595153e-03  3.677490e-03  3.758359e-03
## ASV0032      7.870514e-03  8.103365e-03  8.342390e-03  8.587858e-03
## ASV2977     -7.128078e-03 -7.340349e-03 -7.556250e-03 -7.775718e-03
## ASV0466      5.514600e-03  5.630803e-03  5.746457e-03  5.861404e-03
## ASV3866      1.043349e-02  1.085510e-02  1.129282e-02  1.174721e-02
## ASV0040      1.461557e-02  1.518122e-02  1.576391e-02  1.636384e-02
## ASV0496     -3.641698e-03 -3.836480e-03 -4.039218e-03 -4.250070e-03
## ASV0052      1.225862e-02  1.261458e-02  1.297663e-02  1.334474e-02
## ASV3828     -8.208433e-03 -8.505199e-03 -8.812156e-03 -9.129656e-03
## ASV1930      4.852034e-03  4.987825e-03  5.125503e-03  5.265036e-03
## ASV2126      8.101993e-03  8.352801e-03  8.608701e-03  8.869681e-03
## ASV0793      8.439799e-03  8.796585e-03  9.165726e-03  9.547517e-03
## ASV0299     -1.790096e-03 -1.847996e-03 -1.909926e-03 -1.976221e-03
## ASV0208      1.179007e-02  1.230155e-02  1.283270e-02  1.338406e-02
## ASV0511     -8.710276e-04 -8.362821e-04 -7.994031e-04 -7.604429e-04
## ASV1123     -3.159624e-03 -3.206097e-03 -3.250929e-03 -3.293949e-03
## ASV0099     -1.061133e-03 -9.993674e-04 -9.291686e-04 -8.500302e-04
## ASV0752     -1.688744e-03 -1.762991e-03 -1.839759e-03 -1.919101e-03
## ASV0883      8.155340e-04  8.562443e-04  8.983991e-04  9.420216e-04
## ASV0683      9.677490e-03  1.005972e-02  1.045368e-02  1.085946e-02
## ASV4117     -8.165601e-03 -8.444294e-03 -8.730789e-03 -9.025222e-03
## ASV2172      3.553538e-03  3.685153e-03  3.820930e-03  3.960966e-03
## ASV0330     -6.337718e-03 -6.562753e-03 -6.794522e-03 -7.033213e-03
## ASV0728      7.252463e-03  7.532095e-03  7.820665e-03  8.118395e-03
## ASV0499      1.543052e-02  1.607870e-02  1.674980e-02  1.744429e-02
## ASV0120     -1.134340e-02 -1.167749e-02 -1.201659e-02 -1.236055e-02
## ASV1446     -1.572250e-03 -1.709595e-03 -1.856013e-03 -2.011964e-03
## ASV17171    -8.215974e-03 -8.513668e-03 -8.820774e-03 -9.137497e-03
## ASV0533      3.738286e-03  3.903432e-03  4.074506e-03  4.251588e-03
## ASV2495     -5.086085e-03 -5.312524e-03 -5.547242e-03 -5.790375e-03
## ASV5582      1.051428e-03  1.045400e-03  1.037331e-03  1.027098e-03
## ASV1488      3.443151e-03  3.566351e-03  3.692259e-03  3.820833e-03
## ASV0682      1.038594e-02  1.080352e-02  1.123431e-02  1.167846e-02
## ASV0068     -2.245940e-03 -2.338954e-03 -2.433254e-03 -2.528672e-03
## ASV1987     -7.307672e-03 -7.641684e-03 -7.988890e-03 -8.349646e-03
## ASV0035     -4.068180e-03 -4.396812e-03 -4.745656e-03 -5.115576e-03
## ASV7192     -3.395696e-03 -3.453228e-03 -3.509361e-03 -3.563974e-03
## ASV0873     -4.836991e-04 -5.132761e-04 -5.432905e-04 -5.736722e-04
## ASV4749     -3.520868e-03 -3.744241e-03 -3.978298e-03 -4.223349e-03
## ASV2174      3.363122e-03  3.464511e-03  3.570337e-03  3.680911e-03
## ASV1476     -5.647713e-03 -5.873628e-03 -6.106967e-03 -6.347854e-03
## ASV0740     -1.462789e-02 -1.521094e-02 -1.581296e-02 -1.643430e-02
## ASV0170      2.662227e-03  2.764641e-03  2.870618e-03  2.980276e-03
## ASV2466     -1.110414e-02 -1.152942e-02 -1.196909e-02 -1.242350e-02
## ASV1709      7.178873e-03  7.401831e-03  7.629316e-03  7.861319e-03
## ASV6170     -8.299714e-03 -8.601660e-03 -8.911946e-03 -9.230653e-03
## ASV3673      9.662413e-03  1.001870e-02  1.038510e-02  1.076174e-02
## ASV1745      6.445755e-04  6.592869e-04  6.735119e-04  6.871645e-04
##                                                                    
## (Intercept) -1.176721e-02 -1.252112e-02 -1.331063e-02 -1.413666e-02
## ASV1236      4.856179e-03  4.979194e-03  5.104141e-03  5.231033e-03
## ASV0421     -8.973077e-03 -9.204583e-03 -9.439936e-03 -9.679191e-03
## ASV0691     -6.135444e-03 -6.271192e-03 -6.408747e-03 -6.548115e-03
## ASV0899      5.710579e-04  5.829573e-04  5.945452e-04  6.058379e-04
## ASV1004      9.890218e-03  1.012262e-02  1.035708e-02  1.059352e-02
## ASV1041     -6.296481e-03 -6.424678e-03 -6.552883e-03 -6.681041e-03
## ASV1058      9.930910e-03  1.020163e-02  1.047722e-02  1.075773e-02
## ASV12542     2.154846e-03  2.203166e-03  2.252501e-03  2.302897e-03
## ASV1294      1.250760e-02  1.286463e-02  1.322864e-02  1.359971e-02
## ASV13113     8.224757e-03  8.581164e-03  8.951039e-03  9.334740e-03
## ASV1318      9.780054e-03  1.003086e-02  1.028535e-02  1.054353e-02
## ASV2269     -2.787105e-03 -2.851893e-03 -2.917267e-03 -2.983209e-03
## ASV2542      1.063681e-02  1.104175e-02  1.145889e-02  1.188836e-02
## ASV2660     -4.914362e-03 -5.027895e-03 -5.142898e-03 -5.259386e-03
## ASV2737     -7.622456e-04 -7.839702e-04 -8.057606e-04 -8.275874e-04
## ASV2840      5.700797e-03  5.800345e-03  5.899462e-03  5.998119e-03
## ASV3053      4.011486e-04  4.193352e-04  4.384003e-04  4.583732e-04
## ASV3077      2.363111e-03  2.432624e-03  2.503809e-03  2.576693e-03
## ASV3134      1.574639e-02  1.641443e-02  1.710711e-02  1.782506e-02
## ASV3140      5.200670e-03  5.371098e-03  5.545183e-03  5.722900e-03
## ASV3579      4.578788e-03  4.782799e-03  4.992968e-03  5.209277e-03
## ASV6119     -2.787872e-03 -2.852900e-03 -2.918490e-03 -2.984611e-03
## ASV7557     -2.788175e-03 -2.853238e-03 -2.918856e-03 -2.984999e-03
## ASV8422      1.381069e-03  1.419900e-03  1.459801e-03  1.500814e-03
## ASV1086     -7.889733e-04 -8.168903e-04 -8.458703e-04 -8.759508e-04
## ASV1310      5.674037e-03  5.797222e-03  5.919553e-03  6.040839e-03
## ASV15750    -8.854394e-04 -8.908205e-04 -8.952552e-04 -8.986746e-04
## ASV16905    -2.790066e-03 -2.855299e-03 -2.921074e-03 -2.987357e-03
## ASV2033      9.269557e-03  9.605116e-03  9.949729e-03  1.030354e-02
## ASV2089      1.908662e-03  1.950650e-03  1.992742e-03  2.034902e-03
## ASV2127      8.434300e-03  8.660959e-03  8.890970e-03  9.124284e-03
## ASV2725      7.597453e-03  7.760647e-03  7.925247e-03  8.091282e-03
## ASV2804     -2.791416e-03 -2.856725e-03 -2.922562e-03 -2.988894e-03
## ASV3075      8.166255e-03  8.478679e-03  8.801897e-03  9.136158e-03
## ASV3327      8.940719e-03  9.275305e-03  9.619872e-03  9.974598e-03
## ASV3342      8.480175e-03  8.772947e-03  9.073419e-03  9.381681e-03
## ASV3532     -8.195822e-03 -8.518230e-03 -8.852623e-03 -9.199400e-03
## ASV3600      9.476139e-03  9.798927e-03  1.012985e-02  1.046897e-02
## ASV4013      6.016717e-03  6.169513e-03  6.323562e-03  6.478777e-03
## ASV4136      5.514845e-03  5.666552e-03  5.821287e-03  5.979075e-03
## ASV4195      2.793018e-03  2.858391e-03  2.924282e-03  2.990660e-03
## ASV4407     -2.793365e-03 -2.858738e-03 -2.924625e-03 -2.990997e-03
## ASV4717     -2.075002e-04 -2.115399e-04 -2.150973e-04 -2.181256e-04
## ASV6794      2.726524e-03  2.809304e-03  2.894637e-03  2.982598e-03
## ASV8324     -2.794663e-03 -2.860096e-03 -2.926040e-03 -2.992469e-03
## ASV8981      8.404027e-04  9.114396e-04  9.857616e-04  1.063407e-03
## ASV9859      6.649865e-03  6.987967e-03  7.341597e-03  7.711313e-03
## ASV0936     -5.100475e-03 -5.246726e-03 -5.395830e-03 -5.547807e-03
## ASV12683    -7.958432e-04 -8.156318e-04 -8.352327e-04 -8.546026e-04
## ASV1293      6.620620e-03  6.791885e-03  6.965937e-03  7.142805e-03
## ASV13055    -7.932342e-05 -5.987732e-05 -3.884092e-05 -1.613951e-05
## ASV17063    -2.795760e-03 -2.861110e-03 -2.926959e-03 -2.993285e-03
## ASV2228      2.795907e-03  2.861254e-03  2.927103e-03  2.993434e-03
## ASV2769      3.930007e-04  4.148855e-04  4.367487e-04  4.585149e-04
## ASV2803      1.017457e-03  1.044194e-03  1.071830e-03  1.100404e-03
## ASV2896      6.785861e-03  7.105355e-03  7.440264e-03  7.791306e-03
## ASV3062      3.632858e-03  3.797068e-03  3.966631e-03  4.141578e-03
## ASV3107      6.574683e-03  6.811223e-03  7.054430e-03  7.304378e-03
## ASV3265      8.286775e-03  8.482996e-03  8.680878e-03  8.880331e-03
## ASV3666     -6.508529e-04 -6.829078e-04 -7.161240e-04 -7.505137e-04
## ASV4497      2.142564e-03  2.201840e-03  2.262375e-03  2.324197e-03
## ASV6914     -1.388702e-03 -1.432250e-03 -1.476704e-03 -1.522075e-03
## ASV0576     -8.595828e-03 -8.798497e-03 -9.004361e-03 -9.213461e-03
## ASV0673      4.329281e-03  4.463254e-03  4.599559e-03  4.738207e-03
## ASV0772      4.254126e-03  4.403660e-03  4.557620e-03  4.716086e-03
## ASV0862     -1.116289e-03 -1.117134e-03 -1.117552e-03 -1.117593e-03
## ASV0898      4.862993e-03  5.038738e-03  5.218947e-03  5.403683e-03
## ASV0910      1.028590e-02  1.068409e-02  1.109470e-02  1.151800e-02
## ASV0964     -3.020815e-03 -3.080514e-03 -3.140504e-03 -3.200784e-03
## ASV10059     5.664853e-03  5.912873e-03  6.170421e-03  6.437784e-03
## ASV10263    -2.799330e-03 -2.864991e-03 -2.931224e-03 -2.998022e-03
## ASV1088      6.586655e-03  6.881516e-03  7.187703e-03  7.505497e-03
## ASV1101      4.926479e-03  5.016344e-03  5.104259e-03  5.190035e-03
## ASV1183      4.339864e-03  4.482229e-03  4.628205e-03  4.777855e-03
## ASV11956     7.388899e-04  7.570455e-04  7.759446e-04  7.956188e-04
## ASV12774    -9.424101e-04 -9.787252e-04 -1.016093e-03 -1.054537e-03
## ASV1321      4.255959e-03  4.444062e-03  4.637954e-03  4.837646e-03
## ASV13793    -2.800465e-03 -2.866347e-03 -2.932856e-03 -2.999992e-03
## ASV14482    -4.668933e-04 -4.747893e-04 -4.823348e-04 -4.895175e-04
## ASV15483     3.245453e-03  3.364535e-03  3.487277e-03  3.613773e-03
## ASV2062      1.565816e-02  1.612768e-02  1.660627e-02  1.709390e-02
## ASV2132      9.239265e-03  9.570915e-03  9.911393e-03  1.026076e-02
## ASV2413      9.047979e-03  9.311662e-03  9.581033e-03  9.856165e-03
## ASV2490      4.642944e-03  4.743846e-03  4.845581e-03  4.948147e-03
## ASV2594      5.164289e-03  5.392350e-03  5.629947e-03  5.877383e-03
## ASV2822     -2.802483e-03 -2.868720e-03 -2.935643e-03 -3.003255e-03
## ASV2863      5.011077e-03  5.145622e-03  5.282723e-03  5.422420e-03
## ASV2910      6.316936e-03  6.482644e-03  6.651615e-03  6.823934e-03
## ASV2980      1.983064e-03  2.019583e-03  2.055995e-03  2.092296e-03
## ASV3307      2.804353e-03  2.870931e-03  2.938244e-03  3.006297e-03
## ASV3474      8.417850e-03  8.727437e-03  9.044543e-03  9.369121e-03
## ASV3502      1.266795e-02  1.310427e-02  1.355369e-02  1.401654e-02
## ASV4236      4.144452e-03  4.239068e-03  4.334883e-03  4.431910e-03
## ASV4842     -1.476984e-03 -1.504777e-03 -1.532377e-03 -1.559771e-03
## ASV4894     -2.806290e-03 -2.873171e-03 -2.940820e-03 -3.009241e-03
## ASV5290      4.197404e-03  4.310219e-03  4.424493e-03  4.540218e-03
## ASV5501      1.323252e-03  1.387557e-03  1.454706e-03  1.524778e-03
## ASV5795      4.031539e-03  4.174578e-03  4.320953e-03  4.470638e-03
## ASV5987     -2.808363e-03 -2.875550e-03 -2.943534e-03 -3.012318e-03
## ASV6267     -2.809127e-03 -2.876427e-03 -2.944534e-03 -3.013451e-03
## ASV6862      4.727233e-03  4.844366e-03  4.963715e-03  5.085321e-03
## ASV7145      1.135713e-03  1.181680e-03  1.229465e-03  1.279110e-03
## ASV7673     -2.810767e-03 -2.878279e-03 -2.946613e-03 -3.015772e-03
## ASV7789      4.066919e-03  4.267300e-03  4.475469e-03  4.691591e-03
## ASV7809      8.484003e-04  8.986824e-04  9.505075e-04  1.003852e-03
## ASV8002     -2.813211e-03 -2.881045e-03 -2.949725e-03 -3.019254e-03
## ASV8205      2.694635e-03  2.798923e-03  2.906406e-03  3.017118e-03
## ASV9155     -1.913445e-03 -1.952932e-03 -1.992552e-03 -2.032288e-03
## ASV9221      1.448524e-03  1.543796e-03  1.643556e-03  1.747936e-03
## ASV9311     -2.816889e-03 -2.885144e-03 -2.954267e-03 -3.024256e-03
## ASV9557     -2.817903e-03 -2.886261e-03 -2.955490e-03 -3.025589e-03
## ASV9936     -2.818918e-03 -2.887376e-03 -2.956707e-03 -3.026909e-03
## ASV1445      1.048664e-02  1.087451e-02  1.127415e-02  1.168578e-02
## ASV4232      1.179539e-02  1.232712e-02  1.288057e-02  1.345644e-02
## ASV6479      2.787251e-03  2.949639e-03  3.119115e-03  3.295841e-03
## ASV0142     -1.362116e-02 -1.395277e-02 -1.428866e-02 -1.462883e-02
## ASV0378     -2.685079e-03 -2.688301e-03 -2.688562e-03 -2.685805e-03
## ASV1122      1.327768e-02  1.373406e-02  1.420175e-02  1.468081e-02
## ASV0123     -1.317390e-02 -1.348790e-02 -1.380552e-02 -1.412671e-02
## ASV2064      7.812742e-04  7.945286e-04  8.084934e-04  8.232585e-04
## ASV4459     -1.470086e-03 -1.510814e-03 -1.552717e-03 -1.595834e-03
## ASV0448      6.740818e-03  7.033191e-03  7.335190e-03  7.646917e-03
## ASV0397      8.916333e-03  9.203179e-03  9.496467e-03  9.796217e-03
## ASV0485      1.191967e-02  1.231919e-02  1.272979e-02  1.315166e-02
## ASV1566      1.021996e-02  1.054393e-02  1.087522e-02  1.121392e-02
## ASV1365      6.658733e-03  6.856213e-03  7.056624e-03  7.259892e-03
## ASV1065      1.424273e-02  1.471635e-02  1.520129e-02  1.569759e-02
## ASV0722     -2.469325e-04 -2.696615e-04 -2.944300e-04 -3.213678e-04
## ASV12660    -4.284790e-03 -4.385426e-03 -4.487326e-03 -4.590498e-03
## ASV0223      4.821689e-04  5.290974e-04  5.791404e-04  6.324133e-04
## ASV0229      7.793651e-03  8.096333e-03  8.408981e-03  8.731826e-03
## ASV0877     -1.068000e-03 -1.093012e-03 -1.119186e-03 -1.146610e-03
## ASV0983      1.063379e-02  1.093769e-02  1.124708e-02  1.156196e-02
## ASV0626     -9.197841e-04 -9.083890e-04 -8.965312e-04 -8.842864e-04
## ASV4146     -9.218209e-04 -9.862296e-04 -1.055666e-03 -1.130453e-03
## ASV4175     -7.454188e-03 -7.680888e-03 -7.911801e-03 -8.146888e-03
## ASV2082     -3.153691e-03 -3.328085e-03 -3.509880e-03 -3.699224e-03
## ASV2272      6.998431e-03  7.259021e-03  7.526870e-03  7.802031e-03
## ASV2245     -7.162592e-03 -7.407149e-03 -7.658347e-03 -7.916306e-03
## ASV0590     -7.297738e-03 -7.607938e-03 -7.928786e-03 -8.260518e-03
## ASV0217      1.108416e-03  1.283423e-03  1.467134e-03  1.659703e-03
## ASV0416      2.459297e-03  2.455431e-03  2.447587e-03  2.435543e-03
## ASV1056      1.003732e-02  1.039444e-02  1.075998e-02  1.113397e-02
## ASV7777     -7.301485e-03 -7.577777e-03 -7.864306e-03 -8.161486e-03
## ASV0455      1.591842e-03  1.624809e-03  1.656585e-03  1.687034e-03
## ASV0604      3.784029e-03  3.950960e-03  4.123574e-03  4.301988e-03
## ASV6100     -7.094831e-03 -7.371968e-03 -7.659482e-03 -7.957749e-03
## ASV11359    -6.183483e-03 -6.358214e-03 -6.535489e-03 -6.715256e-03
## ASV6604      6.427657e-03  6.675762e-03  6.931427e-03  7.194754e-03
## ASV5004     -3.988676e-03 -4.130152e-03 -4.276420e-03 -4.427638e-03
## ASV1483     -3.741565e-03 -3.864021e-03 -3.989268e-03 -4.117291e-03
## ASV9773     -8.598936e-03 -8.913135e-03 -9.237564e-03 -9.572505e-03
## ASV4059      2.485522e-03  2.599435e-03  2.716689e-03  2.837244e-03
## ASV1193      1.263859e-02  1.303829e-02  1.344642e-02  1.386294e-02
## ASV4610      8.720830e-04  9.111956e-04  9.499123e-04  9.880789e-04
## ASV0742     -1.057027e-03 -1.038061e-03 -1.018120e-03 -9.972740e-04
## ASV1502     -1.359574e-03 -1.424957e-03 -1.492269e-03 -1.561494e-03
## ASV0195     -2.948792e-03 -3.077960e-03 -3.212025e-03 -3.351151e-03
## ASV1213      1.734023e-03  1.734749e-03  1.732867e-03  1.728238e-03
## ASV1648     -6.456966e-03 -6.707546e-03 -6.967563e-03 -7.237344e-03
## ASV6984     -5.424068e-03 -5.651398e-03 -5.888090e-03 -6.134496e-03
## ASV0396      1.952491e-03  2.092093e-03  2.235566e-03  2.382749e-03
## ASV4297      4.510662e-03  4.621122e-03  4.733163e-03  4.846788e-03
## ASV2622      1.174885e-02  1.208004e-02  1.241829e-02  1.276374e-02
## ASV3512      6.094084e-03  6.412228e-03  6.745178e-03  7.093484e-03
## ASV2411      7.045468e-03  7.300216e-03  7.560253e-03  7.825389e-03
## ASV2291     -3.241365e-03 -3.390409e-03 -3.544568e-03 -3.703900e-03
## ASV0807      9.825518e-03  1.020863e-02  1.060254e-02  1.100737e-02
## ASV1292      3.085163e-03  3.196434e-03  3.311768e-03  3.431300e-03
## ASV1035      1.076050e-03  1.116301e-03  1.158354e-03  1.202279e-03
## ASV0070      9.801555e-04  1.129485e-03  1.287881e-03  1.455625e-03
## ASV0255      2.851183e-04  2.214231e-04  1.500874e-04  7.060440e-05
## ASV0057     -7.955778e-03 -8.031316e-03 -8.100182e-03 -8.162001e-03
## ASV0077      1.028773e-03  1.114089e-03  1.201302e-03  1.290163e-03
## ASV0625      1.048456e-02  1.071413e-02  1.094434e-02  1.117501e-02
## ASV2464      4.757645e-03  4.866561e-03  4.976703e-03  5.088074e-03
## ASV1315      1.763350e-02  1.829019e-02  1.896452e-02  1.965654e-02
## ASV2673      1.478081e-02  1.541339e-02  1.606971e-02  1.675040e-02
## ASV2161      6.388909e-03  6.664303e-03  6.949604e-03  7.245001e-03
## ASV0337     -5.435196e-03 -5.585757e-03 -5.738866e-03 -5.894516e-03
## ASV7680     -8.308972e-03 -8.599363e-03 -8.897481e-03 -9.203383e-03
## ASV0611      2.151791e-02  2.237199e-02  2.325468e-02  2.416657e-02
## ASV3118     -6.528844e-03 -6.759453e-03 -6.996050e-03 -7.238673e-03
## ASV1284      6.935169e-03  7.174439e-03  7.418984e-03  7.668742e-03
## ASV0889      4.494273e-03  4.662656e-03  4.837418e-03  5.018805e-03
## ASV4649     -4.767444e-03 -4.925198e-03 -5.086823e-03 -5.252346e-03
## ASV1108     -9.183117e-03 -9.561919e-03 -9.953228e-03 -1.035724e-02
## ASV0738      5.846012e-03  6.210602e-03  6.593031e-03  6.993932e-03
## ASV0473      1.391380e-03  1.452510e-03  1.516201e-03  1.582584e-03
## ASV0598     -3.366730e-03 -3.401074e-03 -3.432829e-03 -3.461814e-03
## ASV0429      9.128191e-03  9.379948e-03  9.635967e-03  9.896279e-03
## ASV1549      1.622839e-02  1.687772e-02  1.754635e-02  1.823436e-02
## ASV1203      7.471728e-03  7.683984e-03  7.899046e-03  8.116785e-03
## ASV4532      4.011054e-04  4.434408e-04  4.896928e-04  5.401146e-04
## ASV0274     -4.757517e-03 -4.857448e-03 -4.959009e-03 -5.062314e-03
## ASV0163     -6.232242e-03 -6.333993e-03 -6.435137e-03 -6.535630e-03
## ASV1298      3.311634e-03  3.423134e-03  3.539728e-03  3.661731e-03
## ASV9424     -1.217959e-02 -1.264639e-02 -1.312865e-02 -1.362674e-02
## ASV0412      1.405426e-02  1.447522e-02  1.490431e-02  1.534153e-02
## ASV0284      4.032200e-03  4.088741e-03  4.142306e-03  4.192593e-03
## ASV0620     -7.424768e-03 -7.710540e-03 -8.004814e-03 -8.307723e-03
## ASV0153     -1.331305e-02 -1.377200e-02 -1.424025e-02 -1.471757e-02
## ASV0498      4.586001e-03  4.759637e-03  4.935253e-03  5.112565e-03
## ASV0097      1.141031e-02  1.188125e-02  1.236795e-02  1.287067e-02
## ASV0104     -3.375090e-02 -3.478935e-02 -3.584913e-02 -3.693027e-02
## ASV1282      6.352891e-03  6.533965e-03  6.716402e-03  6.899971e-03
## ASV3883     -4.442870e-03 -4.577751e-03 -4.713397e-03 -4.849555e-03
## ASV0801      6.018966e-03  6.280255e-03  6.551505e-03  6.833008e-03
## ASV1611     -1.611887e-02 -1.670281e-02 -1.730317e-02 -1.792015e-02
## ASV0227     -8.407378e-03 -8.765024e-03 -9.135713e-03 -9.519827e-03
## ASV0833      8.347960e-03  8.669021e-03  8.998861e-03  9.337521e-03
## ASV0718      1.320995e-02  1.363180e-02  1.406203e-02  1.450056e-02
## ASV1139      4.634394e-04  3.752113e-04  2.804413e-04  1.789449e-04
## ASV0766     -2.550556e-03 -2.620566e-03 -2.692212e-03 -2.765543e-03
## ASV2091      1.165822e-02  1.193232e-02  1.220959e-02  1.249001e-02
## ASV1238      1.891702e-03  2.001033e-03  2.113458e-03  2.228892e-03
## ASV9193     -4.029048e-03 -4.196573e-03 -4.368147e-03 -4.543689e-03
## ASV0290     -2.081199e-03 -2.117909e-03 -2.151829e-03 -2.182692e-03
## ASV0231      1.272034e-02  1.310275e-02  1.349194e-02  1.388783e-02
## ASV0185      1.392939e-02  1.469390e-02  1.549261e-02  1.632657e-02
## ASV2330      2.998400e-03  3.088250e-03  3.180778e-03  3.276079e-03
## ASV3119     -9.031437e-03 -9.442717e-03 -9.869556e-03 -1.031234e-02
## ASV2368     -9.568219e-03 -9.994698e-03 -1.043829e-02 -1.089948e-02
## ASV0122     -3.089345e-03 -3.170385e-03 -3.254268e-03 -3.341227e-03
## ASV1044      1.354193e-02  1.410758e-02  1.469252e-02  1.529713e-02
## ASV0160     -5.830480e-03 -5.909020e-03 -5.986638e-03 -6.063360e-03
## ASV0326      7.599920e-03  7.821193e-03  8.045182e-03  8.271694e-03
## ASV1388      1.339765e-02  1.383499e-02  1.428315e-02  1.474222e-02
## ASV0792      1.217180e-02  1.247673e-02  1.278450e-02  1.309499e-02
## ASV0036     -1.091887e-02 -1.125356e-02 -1.159181e-02 -1.193318e-02
## ASV2125      1.486678e-02  1.530004e-02  1.573960e-02  1.618521e-02
## ASV1075      4.566752e-03  4.754860e-03  4.949296e-03  5.150179e-03
## ASV0390      7.612319e-03  8.009446e-03  8.425010e-03  8.859658e-03
## ASV3790     -1.450395e-02 -1.501698e-02 -1.554410e-02 -1.608549e-02
## ASV1535     -2.659129e-03 -2.777454e-03 -2.899115e-03 -3.024069e-03
## ASV0263      2.942559e-03  3.049195e-03  3.159128e-03  3.272435e-03
## ASV0675      2.825680e-02  2.934342e-02  3.046217e-02  3.161337e-02
## ASV3348      3.994551e-03  4.180909e-03  4.374683e-03  4.576067e-03
## ASV0058     -1.736586e-02 -1.783552e-02 -1.831086e-02 -1.879166e-02
## ASV4142      4.086093e-03  4.202351e-03  4.321331e-03  4.443110e-03
## ASV0059     -1.435303e-02 -1.471885e-02 -1.508764e-02 -1.545916e-02
## ASV0013     -3.465670e-02 -3.574495e-02 -3.685730e-02 -3.799391e-02
## ASV0033     -1.264167e-02 -1.306441e-02 -1.349495e-02 -1.393304e-02
## ASV4354     -3.968334e-03 -4.093446e-03 -4.221327e-03 -4.351943e-03
## ASV0022     -1.277231e-02 -1.317444e-02 -1.358172e-02 -1.399371e-02
## ASV0134     -5.044573e-03 -5.285347e-03 -5.537566e-03 -5.801770e-03
## ASV0415      7.384232e-04  8.137853e-04  8.923991e-04  9.743155e-04
## ASV10103    -8.734426e-03 -9.028983e-03 -9.330176e-03 -9.637978e-03
## ASV1613      9.563619e-03  9.781391e-03  9.999445e-03  1.021759e-02
## ASV0135      5.177782e-03  5.506931e-03  5.852205e-03  6.214115e-03
## ASV0469     -1.299974e-02 -1.337921e-02 -1.376702e-02 -1.416329e-02
## ASV0471      1.098643e-02  1.139011e-02  1.180747e-02  1.223894e-02
## ASV0451     -5.006334e-03 -5.212207e-03 -5.424069e-03 -5.641945e-03
## ASV0747      6.053249e-03  6.275466e-03  6.502630e-03  6.734690e-03
## ASV1314     -1.098138e-02 -1.150299e-02 -1.204691e-02 -1.261387e-02
## ASV0425     -1.147835e-02 -1.172228e-02 -1.196801e-02 -1.221552e-02
## ASV0559     -8.424659e-03 -8.720963e-03 -9.028389e-03 -9.347335e-03
## ASV0148     -5.554670e-03 -5.590175e-03 -5.619397e-03 -5.641978e-03
## ASV0129      4.825219e-04  6.448002e-04  8.171308e-04  9.997542e-04
## ASV1072      2.314591e-03  2.326334e-03  2.336835e-03  2.346182e-03
## ASV2390      1.339690e-03  1.321526e-03  1.300568e-03  1.276761e-03
## ASV0548      1.281949e-02  1.326341e-02  1.371900e-02  1.418637e-02
## ASV0168     -1.517658e-02 -1.564241e-02 -1.611975e-02 -1.660883e-02
## ASV0066     -1.090665e-02 -1.118463e-02 -1.146389e-02 -1.174409e-02
## ASV0468     -5.406656e-03 -5.622126e-03 -5.846289e-03 -6.079497e-03
## ASV0172      2.571334e-03  2.776195e-03  2.990889e-03  3.215635e-03
## ASV0236      2.278903e-04  3.780361e-04  5.362083e-04  7.024505e-04
## ASV0250      9.551557e-03  1.010739e-02  1.068857e-02  1.129583e-02
## ASV0338      2.067879e-03  2.173026e-03  2.281007e-03  2.391802e-03
## ASV0450     -3.177283e-04 -3.538357e-04 -3.932509e-04 -4.361714e-04
## ASV0377      1.363151e-02  1.403276e-02  1.443951e-02  1.485146e-02
## ASV1022      4.973769e-03  5.177488e-03  5.388897e-03  5.608236e-03
## ASV6174     -9.529045e-04 -9.819529e-04 -1.010659e-03 -1.038843e-03
## ASV0786      6.727001e-04  6.803326e-04  6.878884e-04  6.953845e-04
## ASV0053     -1.720652e-02 -1.775357e-02 -1.831216e-02 -1.888226e-02
## ASV0697     -2.380446e-03 -2.409127e-03 -2.437430e-03 -2.465455e-03
## ASV0785      1.299234e-02  1.344068e-02  1.390298e-02  1.437970e-02
## ASV1967     -5.934255e-03 -6.084505e-03 -6.236920e-03 -6.391484e-03
## ASV0385     -1.730411e-03 -1.753380e-03 -1.776500e-03 -1.799816e-03
## ASV0295      5.190744e-03  5.499180e-03  5.821617e-03  6.158399e-03
## ASV0072     -8.039010e-03 -8.149626e-03 -8.255919e-03 -8.357663e-03
## ASV0157      1.358777e-04  3.348512e-04  5.505179e-04  7.836983e-04
## ASV0501      9.405079e-03  9.773105e-03  1.015152e-02  1.054039e-02
## ASV10729    -1.135365e-02 -1.173131e-02 -1.211752e-02 -1.251229e-02
## ASV1470      3.261751e-03  3.315102e-03  3.366583e-03  3.416005e-03
## ASV0050     -2.984558e-02 -3.069498e-02 -3.155821e-02 -3.243509e-02
## ASV0411      1.028239e-03  1.084109e-03  1.139761e-03  1.194842e-03
## ASV0549      9.833654e-03  1.024437e-02  1.066913e-02  1.110818e-02
## ASV0184      4.743809e-03  4.932435e-03  5.127599e-03  5.329443e-03
## ASV0705      5.284584e-03  5.440110e-03  5.597016e-03  5.755105e-03
## ASV1715      1.314972e-02  1.360409e-02  1.407046e-02  1.454898e-02
## ASV0603      3.130323e-03  3.302240e-03  3.482859e-03  3.672498e-03
## ASV0826      2.396831e-03  2.437446e-03  2.477379e-03  2.516549e-03
## ASV0034     -1.106084e-02 -1.129648e-02 -1.153182e-02 -1.176667e-02
## ASV0838      1.663792e-03  1.645529e-03  1.621839e-03  1.592404e-03
## ASV0614     -7.041089e-03 -7.215708e-03 -7.391307e-03 -7.567733e-03
## ASV0014     -2.983741e-02 -3.072371e-02 -3.162718e-02 -3.254780e-02
## ASV0585     -2.074656e-03 -2.123668e-03 -2.172023e-03 -2.219603e-03
## ASV0016     -3.081870e-02 -3.174321e-02 -3.268611e-02 -3.364743e-02
## ASV5394     -8.678429e-03 -8.925445e-03 -9.173559e-03 -9.422269e-03
## ASV0666      6.321385e-03  6.498493e-03  6.678521e-03  6.861466e-03
## ASV2085     -1.341019e-03 -1.467393e-03 -1.599942e-03 -1.738831e-03
## ASV0003     -2.738723e-02 -2.819500e-02 -2.901879e-02 -2.985870e-02
## ASV0346      3.674105e-03  3.869930e-03  4.072590e-03  4.282163e-03
## ASV0267     -1.837498e-03 -1.850357e-03 -1.863928e-03 -1.878482e-03
## ASV0353      1.201624e-02  1.253439e-02  1.306989e-02  1.362296e-02
## ASV2419      7.367325e-03  7.571743e-03  7.778722e-03  7.988096e-03
## ASV0447      8.940109e-03  9.325721e-03  9.724236e-03  1.013591e-02
## ASV0654      1.450851e-02  1.496368e-02  1.542747e-02  1.589985e-02
## ASV0151      6.733452e-03  7.084093e-03  7.449713e-03  7.830711e-03
## ASV0065     -1.081470e-02 -1.110711e-02 -1.140325e-02 -1.170302e-02
## ASV0527      8.407489e-03  8.656669e-03  8.910153e-03  9.167881e-03
## ASV4055     -6.230303e-03 -6.547929e-03 -6.881621e-03 -7.232135e-03
## ASV0166     -7.209292e-03 -7.379251e-03 -7.551317e-03 -7.725531e-03
## ASV0417     -7.665077e-03 -7.899702e-03 -8.140046e-03 -8.386240e-03
## ASV0078     -3.191429e-03 -3.165245e-03 -3.130910e-03 -3.088002e-03
## ASV0322     -4.914915e-03 -4.983264e-03 -5.049650e-03 -5.114004e-03
## ASV0156     -9.346564e-03 -9.627170e-03 -9.914747e-03 -1.020948e-02
## ASV0648     -1.208670e-02 -1.252585e-02 -1.297729e-02 -1.344116e-02
## ASV0407      2.445761e-03  2.570127e-03  2.699696e-03  2.834597e-03
## ASV2030     -1.755744e-03 -1.841071e-03 -1.931259e-03 -2.026527e-03
## ASV0300      9.537013e-03  9.908741e-03  1.029009e-02  1.068099e-02
## ASV1150      9.126837e-04  9.782901e-04  1.046143e-03  1.116155e-03
## ASV0958      1.209675e-02  1.268309e-02  1.329465e-02  1.393220e-02
## ASV0216     -8.369570e-03 -8.648692e-03 -8.938169e-03 -9.238460e-03
## ASV0446      1.969890e-02  2.042432e-02  2.116877e-02  2.193233e-02
## ASV0367     -4.854279e-03 -5.014476e-03 -5.178973e-03 -5.347843e-03
## ASV0200     -1.006052e-02 -1.041094e-02 -1.077092e-02 -1.114057e-02
## ASV0334      5.646998e-05  1.327977e-04  2.119200e-04  2.937288e-04
## ASV1311      5.287960e-03  5.416101e-03  5.544510e-03  5.673002e-03
## ASV0458      7.041849e-03  7.274306e-03  7.512578e-03  7.756729e-03
## ASV1371      3.698418e-04  3.805604e-04  3.911661e-04  4.016274e-04
## ASV0418      9.566133e-03  9.913452e-03  1.027153e-02  1.064061e-02
## ASV0004      9.851039e-03  1.014826e-02  1.045078e-02  1.075850e-02
## ASV1943      6.490133e-03  6.681619e-03  6.876902e-03  7.076000e-03
## ASV1495     -5.789721e-03 -6.086538e-03 -6.395895e-03 -6.718112e-03
## ASV0901     -1.577508e-02 -1.640492e-02 -1.705615e-02 -1.772925e-02
## ASV0628      4.046285e-03  4.070734e-03  4.088422e-03  4.098805e-03
## ASV0400      1.408678e-03  1.392047e-03  1.369993e-03  1.342085e-03
## ASV0116     -1.344275e-02 -1.398732e-02 -1.454948e-02 -1.512949e-02
## ASV0788      7.808393e-03  8.063225e-03  8.324108e-03  8.591149e-03
## ASV0117      8.441411e-03  8.813361e-03  9.198855e-03  9.598175e-03
## ASV3137      1.188125e-03  1.238732e-03  1.292589e-03  1.349973e-03
## ASV0001      8.037462e-03  8.203383e-03  8.370033e-03  8.537406e-03
## ASV1651      6.364290e-03  6.563109e-03  6.768887e-03  6.981992e-03
## ASV1692      1.272642e-02  1.323753e-02  1.376581e-02  1.431171e-02
## ASV0660      5.100656e-04  3.857196e-04  2.508890e-04  1.051785e-04
## ASV0508     -1.886271e-04 -2.118302e-04 -2.370532e-04 -2.644864e-04
## ASV1660     -5.296031e-03 -5.485091e-03 -5.677888e-03 -5.874280e-03
## ASV0233      4.157642e-03  4.365109e-03  4.582032e-03  4.808769e-03
## ASV1343     -1.062556e-02 -1.102617e-02 -1.143980e-02 -1.186679e-02
## ASV0209      5.328467e-03  5.448541e-03  5.569794e-03  5.692208e-03
## ASV0193     -8.424220e-03 -8.659655e-03 -8.899900e-03 -9.145015e-03
## ASV0357      3.809773e-03  4.076233e-03  4.357434e-03  4.653956e-03
## ASV0198      3.245608e-03  3.390371e-03  3.540997e-03  3.697631e-03
## ASV0007      7.640903e-03  7.799311e-03  7.958447e-03  8.118307e-03
## ASV1772      3.041652e-04  4.034936e-04  5.131613e-04  6.339197e-04
## ASV0009      6.996927e-03  7.137224e-03  7.278106e-03  7.419590e-03
## ASV0006      1.977997e-04  1.222956e-04  4.287631e-05 -4.044069e-05
## ASV0011     -1.526040e-02 -1.582333e-02 -1.640231e-02 -1.699752e-02
## ASV0015      8.125660e-03  8.355086e-03  8.587022e-03  8.821260e-03
## ASV0017      8.627510e-03  8.878496e-03  9.132997e-03  9.390844e-03
## ASV0235     -8.354349e-03 -8.652894e-03 -8.960522e-03 -9.277499e-03
## ASV0382      3.926985e-03  4.045041e-03  4.161037e-03  4.274445e-03
## ASV2357      1.302338e-02  1.351147e-02  1.401446e-02  1.453253e-02
## ASV0567     -8.179552e-03 -8.489567e-03 -8.810721e-03 -9.143315e-03
## ASV0165      8.835489e-03  9.126565e-03  9.425263e-03  9.731754e-03
## ASV0005      1.397909e-02  1.431782e-02  1.465852e-02  1.500096e-02
## ASV0384      3.454574e-03  3.721334e-03  4.004521e-03  4.304883e-03
## ASV0002      6.469626e-03  6.745475e-03  7.030236e-03  7.323977e-03
## ASV3017      7.933065e-03  8.144837e-03  8.360255e-03  8.579342e-03
## ASV0091      5.004727e-03  5.171907e-03  5.341420e-03  5.513024e-03
## ASV0186     -1.099163e-02 -1.131604e-02 -1.164428e-02 -1.197607e-02
## ASV0370      2.346973e-03  2.474140e-03  2.607756e-03  2.748064e-03
## ASV0018      1.531474e-02  1.571548e-02  1.612079e-02  1.653050e-02
## ASV1377      1.376355e-02  1.415976e-02  1.456356e-02  1.497502e-02
## ASV0019      1.548924e-02  1.590142e-02  1.631884e-02  1.674138e-02
## ASV0023     -2.721329e-03 -2.878428e-03 -3.040417e-03 -3.207230e-03
## ASV2194      8.418593e-03  8.758492e-03  9.109540e-03  9.471916e-03
## ASV1155      1.536238e-03  1.631246e-03  1.730073e-03  1.832800e-03
## ASV0510     -2.446222e-03 -2.455955e-03 -2.464461e-03 -2.471753e-03
## ASV2371     -4.052738e-03 -4.133235e-03 -4.213646e-03 -4.293926e-03
## ASV0024     -3.675194e-03 -3.865948e-03 -4.062614e-03 -4.265159e-03
## ASV2452      5.107391e-03  5.194193e-03  5.280510e-03  5.366328e-03
## ASV2332      3.735170e-03  3.911361e-03  4.093131e-03  4.280502e-03
## ASV2591      3.334175e-03  3.481096e-03  3.631987e-03  3.786825e-03
## ASV0521      1.627638e-02  1.692484e-02  1.759500e-02  1.828738e-02
## ASV5542      5.196318e-03  5.390878e-03  5.591034e-03  5.796871e-03
## ASV0336     -5.605945e-03 -5.812034e-03 -6.026206e-03 -6.248865e-03
## ASV10102     9.286392e-03  9.587977e-03  9.895202e-03  1.020794e-02
## ASV16823    -3.808091e-03 -3.891955e-03 -3.976808e-03 -4.062666e-03
## ASV3104      3.807660e-03  3.891486e-03  3.976300e-03  4.062114e-03
## ASV0781      2.687682e-03  2.777773e-03  2.871083e-03  2.967739e-03
## ASV10899     6.900407e-03  7.213794e-03  7.538538e-03  7.874859e-03
## ASV11222    -3.807124e-03 -3.890904e-03 -3.975667e-03 -4.061427e-03
## ASV11327    -3.806730e-03 -3.890477e-03 -3.975206e-03 -4.060930e-03
## ASV12458    -3.806358e-03 -3.890076e-03 -3.974774e-03 -4.060464e-03
## ASV1636     -2.865607e-03 -2.927112e-03 -2.989724e-03 -3.053495e-03
## ASV1890     -5.096792e-03 -5.271499e-03 -5.452740e-03 -5.640795e-03
## ASV2898      1.151024e-02  1.184029e-02  1.217758e-02  1.252231e-02
## ASV8328      3.306678e-03  3.510784e-03  3.723730e-03  3.945684e-03
## ASV0709     -9.470326e-03 -9.730750e-03 -9.995624e-03 -1.026498e-02
## ASV0856      3.418737e-03  3.560913e-03  3.707370e-03  3.858129e-03
## ASV0909      4.312844e-04  5.490867e-04  6.733795e-04  8.042996e-04
## ASV0937     -1.136783e-02 -1.183307e-02 -1.231508e-02 -1.281425e-02
## ASV11390    -3.805334e-03 -3.888976e-03 -3.973593e-03 -4.059198e-03
## ASV11966     5.602932e-03  5.825096e-03  6.053631e-03  6.288575e-03
## ASV12990     1.788449e-03  1.845884e-03  1.904774e-03  1.965128e-03
## ASV14797     4.711722e-03  4.834120e-03  4.958930e-03  5.086190e-03
## ASV14904    -3.804765e-03 -3.888369e-03 -3.972946e-03 -4.058512e-03
## ASV15304     4.334094e-03  4.518771e-03  4.709015e-03  4.904857e-03
## ASV16696    -3.804479e-03 -3.888069e-03 -3.972633e-03 -4.058185e-03
## ASV1690      5.570529e-03  5.764239e-03  5.961398e-03  6.161895e-03
## ASV2029      1.641083e-02  1.691323e-02  1.742616e-02  1.794965e-02
## ASV2834      1.048000e-02  1.083743e-02  1.120341e-02  1.157792e-02
## ASV4003      7.770609e-03  8.167433e-03  8.582484e-03  9.016477e-03
## ASV4064      7.960804e-03  8.241117e-03  8.529261e-03  8.825405e-03
## ASV4294      6.024693e-03  6.315213e-03  6.617236e-03  6.931024e-03
## ASV4609      6.232783e-04  6.635015e-04  7.055695e-04  7.495206e-04
## ASV6283     -3.803973e-03 -3.887539e-03 -3.972080e-03 -4.057608e-03
## ASV6491     -3.803864e-03 -3.887430e-03 -3.971970e-03 -4.057499e-03
## ASV7453      5.731116e-03  5.973286e-03  6.222603e-03  6.479088e-03
## ASV7959      3.662354e-03  3.849412e-03  4.044050e-03  4.246472e-03
## ASV8219      3.803768e-03  3.887343e-03  3.971895e-03  4.057437e-03
## ASV8547     -3.803749e-03 -3.887332e-03 -3.971892e-03 -4.057445e-03
## ASV9319      6.267415e-03  6.533873e-03  6.810851e-03  7.098707e-03
## ASV9382     -3.803753e-03 -3.887349e-03 -3.971925e-03 -4.057496e-03
## ASV11516    -3.803804e-03 -3.887414e-03 -3.972007e-03 -4.057595e-03
## ASV14377    -3.803880e-03 -3.887507e-03 -3.972118e-03 -4.057727e-03
## ASV1867      1.127351e-02  1.168475e-02  1.210852e-02  1.254510e-02
## ASV1895     -1.514484e-03 -1.569999e-03 -1.627905e-03 -1.688289e-03
## ASV3168      2.247473e-03  2.275299e-03  2.302114e-03  2.327883e-03
## ASV4449      6.413026e-03  6.614518e-03  6.821879e-03  7.035289e-03
## ASV6596      9.146871e-03  9.562979e-03  9.994631e-03  1.044213e-02
## ASV7492      1.092459e-03  1.188973e-03  1.289463e-03  1.393931e-03
## ASV9854     -1.595444e-03 -1.621848e-03 -1.648196e-03 -1.674493e-03
## ASV6296      3.804346e-03  3.888053e-03  3.972753e-03  4.058460e-03
## ASV4201      7.309468e-03  7.672512e-03  8.050349e-03  8.443382e-03
## ASV0552      1.879731e-02  1.943228e-02  2.008005e-02  2.074034e-02
## ASV3671      5.085187e-04  5.329218e-04  5.566825e-04  5.796593e-04
## ASV3529      1.313857e-03  1.383439e-03  1.454288e-03  1.526310e-03
## ASV1060      6.457747e-03  6.768420e-03  7.093616e-03  7.433932e-03
## ASV0239     -4.604740e-03 -4.660502e-03 -4.713751e-03 -4.764327e-03
## ASV5711     -6.165077e-03 -6.333509e-03 -6.504974e-03 -6.679475e-03
## ASV4152     -9.715682e-03 -1.000070e-02 -1.029062e-02 -1.058536e-02
## ASV1461      5.840083e-03  5.960528e-03  6.082010e-03  6.204529e-03
## ASV2877      6.232066e-03  6.374799e-03  6.517213e-03  6.659096e-03
## ASV0012      8.993000e-03  9.351920e-03  9.721537e-03  1.010192e-02
## ASV9823      4.433810e-04  4.266575e-04  4.091985e-04  3.910816e-04
## ASV0008      9.378852e-03  9.750766e-03  1.013389e-02  1.052831e-02
## ASV7832     -5.847232e-03 -6.028638e-03 -6.214222e-03 -6.404018e-03
## ASV1915      1.225640e-03  1.252746e-03  1.278763e-03  1.303569e-03
## ASV0055      3.837428e-03  3.914348e-03  3.988743e-03  4.060220e-03
## ASV0032      8.840058e-03  9.099300e-03  9.365910e-03  9.640238e-03
## ASV2977     -7.998690e-03 -8.225097e-03 -8.454868e-03 -8.687932e-03
## ASV0466      5.975490e-03  6.088556e-03  6.200445e-03  6.311000e-03
## ASV3866      1.221887e-02  1.270839e-02  1.321640e-02  1.374353e-02
## ASV0040      1.698118e-02  1.761608e-02  1.826869e-02  1.893913e-02
## ASV0496     -4.469188e-03 -4.696716e-03 -4.932788e-03 -5.177532e-03
## ASV0052      1.371887e-02  1.409899e-02  1.448506e-02  1.487704e-02
## ASV3828     -9.458064e-03 -9.797752e-03 -1.014911e-02 -1.051253e-02
## ASV1930      5.406391e-03  5.549535e-03  5.694434e-03  5.841053e-03
## ASV2126      9.135725e-03  9.406813e-03  9.682920e-03  9.964015e-03
## ASV0793      9.942262e-03  1.035027e-02  1.077186e-02  1.120737e-02
## ASV0299     -2.047230e-03 -2.123316e-03 -2.204854e-03 -2.292234e-03
## ASV0208      1.395619e-02  1.454963e-02  1.516495e-02  1.580270e-02
## ASV0511     -7.194614e-04 -6.765263e-04 -6.317120e-04 -5.850999e-04
## ASV1123     -3.334978e-03 -3.373827e-03 -3.410299e-03 -3.444186e-03
## ASV0099     -7.614338e-04 -6.628496e-04 -5.537367e-04 -4.335440e-04
## ASV0752     -2.001074e-03 -2.085733e-03 -2.173134e-03 -2.263334e-03
## ASV0883      9.871356e-04  1.033766e-03  1.081937e-03  1.131678e-03
## ASV0683      1.127714e-02  1.170677e-02  1.214838e-02  1.260199e-02
## ASV4117     -9.327726e-03 -9.638433e-03 -9.957473e-03 -1.028498e-02
## ASV2172      4.105356e-03  4.254199e-03  4.407595e-03  4.565647e-03
## ASV0330     -7.279026e-03 -7.532171e-03 -7.792865e-03 -8.061338e-03
## ASV0728      8.425515e-03  8.742258e-03  9.068869e-03  9.405596e-03
## ASV0499      1.816260e-02  1.890516e-02  1.967237e-02  2.046461e-02
## ASV0120     -1.270918e-02 -1.306231e-02 -1.341975e-02 -1.378128e-02
## ASV1446     -2.177922e-03 -2.354376e-03 -2.541825e-03 -2.740779e-03
## ASV17171    -9.464038e-03 -9.800594e-03 -1.014735e-02 -1.050450e-02
## ASV0533      4.434749e-03  4.624049e-03  4.819536e-03  5.021245e-03
## ASV2495     -6.042049e-03 -6.302378e-03 -6.571468e-03 -6.849410e-03
## ASV5582      1.014567e-03  9.996000e-04  9.820499e-04  9.617608e-04
## ASV1488      3.952027e-03  4.085791e-03  4.222071e-03  4.360808e-03
## ASV0682      1.213609e-02  1.260731e-02  1.309221e-02  1.359087e-02
## ASV0068     -2.625032e-03 -2.722151e-03 -2.819839e-03 -2.917901e-03
## ASV1987     -8.724306e-03 -9.113218e-03 -9.516728e-03 -9.935177e-03
## ASV0035     -5.507449e-03 -5.922161e-03 -6.360608e-03 -6.823691e-03
## ASV7192     -3.616949e-03 -3.668169e-03 -3.717522e-03 -3.764897e-03
## ASV0873     -6.043451e-04 -6.352278e-04 -6.662331e-04 -6.972679e-04
## ASV4749     -4.479700e-03 -4.747656e-03 -5.027518e-03 -5.319585e-03
## ASV2174      3.796553e-03  3.917601e-03  4.044401e-03  4.177311e-03
## ASV1476     -6.596414e-03 -6.852766e-03 -7.117026e-03 -7.389307e-03
## ASV0740     -1.707528e-02 -1.773622e-02 -1.841742e-02 -1.911918e-02
## ASV0170      3.093736e-03  3.211123e-03  3.332569e-03  3.458210e-03
## ASV2466     -1.289296e-02 -1.337783e-02 -1.387842e-02 -1.439505e-02
## ASV1709      8.097834e-03  8.338850e-03  8.584358e-03  8.834347e-03
## ASV6170     -9.557851e-03 -9.893605e-03 -1.023797e-02 -1.059101e-02
## ASV3673      1.114872e-02  1.154613e-02  1.195405e-02  1.237257e-02
## ASV1745      7.001542e-04  7.123870e-04  7.237651e-04  7.341873e-04
##                                                                    
## (Intercept) -1.500015e-02 -1.590200e-02 -1.684313e-02 -1.782443e-02
## ASV1236      5.359884e-03  5.490704e-03  5.623505e-03  5.758296e-03
## ASV0421     -9.922407e-03 -1.016965e-02 -1.042098e-02 -1.067647e-02
## ASV0691     -6.689298e-03 -6.832297e-03 -6.977109e-03 -7.123725e-03
## ASV0899      6.168574e-04  6.276322e-04  6.381972e-04  6.485937e-04
## ASV1004      1.083189e-02  1.107214e-02  1.131421e-02  1.155806e-02
## ASV1041     -6.809099e-03 -6.937004e-03 -7.064707e-03 -7.192161e-03
## ASV1058      1.104316e-02  1.133352e-02  1.162884e-02  1.192912e-02
## ASV12542     2.354403e-03  2.407068e-03  2.460944e-03  2.516085e-03
## ASV1294      1.397792e-02  1.436336e-02  1.475611e-02  1.515628e-02
## ASV13113     9.732622e-03  1.014504e-02  1.057235e-02  1.101490e-02
## ASV1318      1.080540e-02  1.107098e-02  1.134027e-02  1.161327e-02
## ASV2269     -3.049704e-03 -3.116731e-03 -3.184267e-03 -3.252288e-03
## ASV2542      1.233032e-02  1.278489e-02  1.325218e-02  1.373231e-02
## ASV2660     -5.377371e-03 -5.496863e-03 -5.617873e-03 -5.740408e-03
## ASV2737     -8.494189e-04 -8.712207e-04 -8.929560e-04 -9.145853e-04
## ASV2840      6.096290e-03  6.193951e-03  6.291083e-03  6.387671e-03
## ASV3053      4.792834e-04  5.011612e-04  5.240371e-04  5.479418e-04
## ASV3077      2.651303e-03  2.727665e-03  2.805805e-03  2.885747e-03
## ASV3134      1.856889e-02  1.933923e-02  2.013669e-02  2.096188e-02
## ASV3140      5.904217e-03  6.089093e-03  6.277482e-03  6.469330e-03
## ASV3579      5.431696e-03  5.660184e-03  5.894688e-03  6.135142e-03
## ASV6119     -3.051233e-03 -3.118320e-03 -3.185837e-03 -3.253744e-03
## ASV7557     -3.051634e-03 -3.118726e-03 -3.186238e-03 -3.254132e-03
## ASV8422      1.542983e-03  1.586353e-03  1.630969e-03  1.676879e-03
## ASV1086     -9.071696e-04 -9.395635e-04 -9.731683e-04 -1.008018e-03
## ASV1310      6.160883e-03  6.279488e-03  6.396457e-03  6.511591e-03
## ASV15750    -9.010064e-04 -9.021749e-04 -9.021014e-04 -9.007050e-04
## ASV16905    -3.054114e-03 -3.121310e-03 -3.188908e-03 -3.256874e-03
## ASV2033      1.066668e-02  1.103930e-02  1.142155e-02  1.181359e-02
## ASV2089      2.077093e-03  2.119278e-03  2.161423e-03  2.203491e-03
## ASV2127      9.360854e-03  9.600625e-03  9.843545e-03  1.008956e-02
## ASV2725      8.258785e-03  8.427798e-03  8.598367e-03  8.770544e-03
## ASV2804     -3.055688e-03 -3.122910e-03 -3.190526e-03 -3.258506e-03
## ASV3075      9.481705e-03  9.838772e-03  1.020758e-02  1.058834e-02
## ASV3327      1.033966e-02  1.071523e-02  1.110148e-02  1.149857e-02
## ASV3342      9.697818e-03  1.002192e-02  1.035406e-02  1.069433e-02
## ASV3532     -9.558967e-03 -9.931742e-03 -1.031815e-02 -1.071862e-02
## ASV3600      1.081634e-02  1.117201e-02  1.153604e-02  1.190844e-02
## ASV4013      6.635066e-03  6.792339e-03  6.950505e-03  7.109474e-03
## ASV4136      6.139941e-03  6.303911e-03  6.471008e-03  6.641258e-03
## ASV4195      3.057496e-03  3.124762e-03  3.192431e-03  3.260480e-03
## ASV4407     -3.057825e-03 -3.125082e-03 -3.192743e-03 -3.260787e-03
## ASV4717     -2.205790e-04 -2.224132e-04 -2.235859e-04 -2.240566e-04
## ASV6794      3.073262e-03  3.166702e-03  3.262988e-03  3.362186e-03
## ASV8324     -3.059354e-03 -3.126673e-03 -3.194403e-03 -3.262523e-03
## ASV8981      1.144404e-03  1.228774e-03  1.316526e-03  1.407661e-03
## ASV9859      8.097676e-03  8.501255e-03  8.922621e-03  9.362347e-03
## ASV0936     -5.702674e-03 -5.860444e-03 -6.021129e-03 -6.184737e-03
## ASV12683    -8.736992e-04 -8.924812e-04 -9.109084e-04 -9.289411e-04
## ASV1293      7.322527e-03  7.505142e-03  7.690696e-03  7.879238e-03
## ASV13055     8.302364e-06  3.456095e-05  6.271354e-05  9.283889e-05
## ASV17063    -3.060068e-03 -3.127288e-03 -3.194930e-03 -3.262978e-03
## ASV2228      3.060230e-03  3.127473e-03  3.195150e-03  3.263247e-03
## ASV2769      4.801052e-04  5.014374e-04  5.224270e-04  5.429877e-04
## ASV2803      1.129954e-03  1.160516e-03  1.192125e-03  1.224818e-03
## ASV2896      8.159226e-03  8.544797e-03  8.948822e-03  9.372132e-03
## ASV3062      4.321932e-03  4.507707e-03  4.698910e-03  4.895537e-03
## ASV3107      7.561132e-03  7.824754e-03  8.095299e-03  8.372819e-03
## ASV3265      9.081258e-03  9.283562e-03  9.487139e-03  9.691883e-03
## ASV3666     -7.860884e-04 -8.228587e-04 -8.608339e-04 -9.000213e-04
## ASV4497      2.387328e-03  2.451793e-03  2.517616e-03  2.584821e-03
## ASV6914     -1.568372e-03 -1.615607e-03 -1.663793e-03 -1.712940e-03
## ASV0576     -9.425839e-03 -9.641534e-03 -9.860584e-03 -1.008302e-02
## ASV0673      4.879218e-03  5.022617e-03  5.168434e-03  5.316709e-03
## ASV0772      4.879134e-03  5.046839e-03  5.219273e-03  5.396506e-03
## ASV0862     -1.117310e-03 -1.116758e-03 -1.115996e-03 -1.115086e-03
## ASV0898      5.593016e-03  5.787018e-03  5.985770e-03  6.189357e-03
## ASV0910      1.195423e-02  1.240365e-02  1.286651e-02  1.334309e-02
## ASV0964     -3.261353e-03 -3.322210e-03 -3.383355e-03 -3.444788e-03
## ASV10059     6.715251e-03  7.003118e-03  7.301689e-03  7.611274e-03
## ASV10263    -3.065379e-03 -3.133289e-03 -3.201748e-03 -3.270753e-03
## ASV1088      7.835176e-03  8.177014e-03  8.531280e-03  8.898236e-03
## ASV1101      5.273486e-03  5.354427e-03  5.432676e-03  5.508051e-03
## ASV1183      4.931247e-03  5.088449e-03  5.249530e-03  5.414557e-03
## ASV11956     8.160987e-04  8.374143e-04  8.595947e-04  8.826687e-04
## ASV12774    -1.094083e-03 -1.134755e-03 -1.176580e-03 -1.219584e-03
## ASV1321      5.043140e-03  5.254427e-03  5.471490e-03  5.694306e-03
## ASV13793    -3.067757e-03 -3.136152e-03 -3.205182e-03 -3.274851e-03
## ASV14482    -4.963262e-04 -5.027514e-04 -5.087845e-04 -5.144182e-04
## ASV15483     3.744123e-03  3.878431e-03  4.016807e-03  4.159366e-03
## ASV2062      1.759054e-02  1.809615e-02  1.861069e-02  1.913410e-02
## ASV2132      1.061908e-02  1.098638e-02  1.136273e-02  1.174814e-02
## ASV2413      1.013713e-02  1.042401e-02  1.071687e-02  1.101578e-02
## ASV2490      5.051545e-03  5.155777e-03  5.260848e-03  5.366766e-03
## ASV2594      6.134961e-03  6.402987e-03  6.681767e-03  6.971608e-03
## ASV2822     -3.071560e-03 -3.140563e-03 -3.210269e-03 -3.280680e-03
## ASV2863      5.564751e-03  5.709755e-03  5.857470e-03  6.007932e-03
## ASV2910      6.999692e-03  7.178988e-03  7.361927e-03  7.548623e-03
## ASV2980      2.128486e-03  2.164563e-03  2.200527e-03  2.236377e-03
## ASV3307      3.075094e-03  3.144641e-03  3.214943e-03  3.286002e-03
## ASV3474      9.701119e-03  1.004047e-02  1.038710e-02  1.074094e-02
## ASV3502      1.449318e-02  1.498397e-02  1.548929e-02  1.600951e-02
## ASV4236      4.530162e-03  4.629651e-03  4.730392e-03  4.832399e-03
## ASV4842     -1.586948e-03 -1.613895e-03 -1.640600e-03 -1.667050e-03
## ASV4894     -3.078439e-03 -3.148417e-03 -3.219178e-03 -3.290724e-03
## ASV5290      4.657393e-03  4.776018e-03  4.896102e-03  5.017658e-03
## ASV5501      1.597852e-03  1.674010e-03  1.753331e-03  1.835892e-03
## ASV5795      4.623599e-03  4.779798e-03  4.939192e-03  5.101729e-03
## ASV5987     -3.081907e-03 -3.152302e-03 -3.223505e-03 -3.295519e-03
## ASV6267     -3.083181e-03 -3.153728e-03 -3.225092e-03 -3.297276e-03
## ASV6862      5.209226e-03  5.335471e-03  5.464097e-03  5.595143e-03
## ASV7145      1.330655e-03  1.384144e-03  1.439615e-03  1.497109e-03
## ASV7673     -3.085757e-03 -3.156571e-03 -3.228215e-03 -3.300691e-03
## ASV7789      4.915831e-03  5.148349e-03  5.389305e-03  5.638855e-03
## ASV7809      1.058691e-03  1.114994e-03  1.172726e-03  1.231851e-03
## ASV8002     -3.089633e-03 -3.160863e-03 -3.232945e-03 -3.305883e-03
## ASV8205      3.131091e-03  3.248351e-03  3.368922e-03  3.492825e-03
## ASV9155     -2.072121e-03 -2.112031e-03 -2.152000e-03 -2.192005e-03
## ASV9221      1.857072e-03  1.971100e-03  2.090159e-03  2.214387e-03
## ASV9311     -3.095112e-03 -3.166835e-03 -3.239425e-03 -3.312884e-03
## ASV9557     -3.096556e-03 -3.168391e-03 -3.241095e-03 -3.314669e-03
## ASV9936     -3.097981e-03 -3.169922e-03 -3.242732e-03 -3.316413e-03
## ASV1445      1.210960e-02  1.254584e-02  1.299468e-02  1.345631e-02
## ASV4232      1.405541e-02  1.467816e-02  1.532539e-02  1.599778e-02
## ASV6479      3.479970e-03  3.671654e-03  3.871033e-03  4.078242e-03
## ASV0142     -1.497326e-02 -1.532194e-02 -1.567486e-02 -1.603200e-02
## ASV0378     -2.679982e-03 -2.671051e-03 -2.658976e-03 -2.643729e-03
## ASV1122      1.517129e-02  1.567325e-02  1.618672e-02  1.671174e-02
## ASV0123     -1.445144e-02 -1.477968e-02 -1.511138e-02 -1.544649e-02
## ASV2064      8.389173e-04  8.555663e-04  8.733037e-04  8.922294e-04
## ASV4459     -1.640207e-03 -1.685877e-03 -1.732886e-03 -1.781276e-03
## ASV0448      7.968462e-03  8.299903e-03  8.641303e-03  8.992715e-03
## ASV0397      1.010244e-02  1.041516e-02  1.073437e-02  1.106009e-02
## ASV0485      1.358501e-02  1.403005e-02  1.448697e-02  1.495599e-02
## ASV1566      1.156010e-02  1.191383e-02  1.227519e-02  1.264423e-02
## ASV1365      7.465942e-03  7.674697e-03  7.886079e-03  8.100010e-03
## ASV1065      1.620530e-02  1.672443e-02  1.725499e-02  1.779699e-02
## ASV0722     -3.506065e-04 -3.822789e-04 -4.165180e-04 -4.534562e-04
## ASV12660    -4.694952e-03 -4.800703e-03 -4.907767e-03 -5.016169e-03
## ASV0223      6.890300e-04  7.491024e-04  8.127402e-04  8.800505e-04
## ASV0229      9.065104e-03  9.409052e-03  9.763912e-03  1.012993e-02
## ASV0877     -1.175380e-03 -1.205595e-03 -1.237362e-03 -1.270793e-03
## ASV0983      1.188231e-02  1.220811e-02  1.253934e-02  1.287598e-02
## ASV0626     -8.717344e-04 -8.589591e-04 -8.460477e-04 -8.330911e-04
## ASV4146     -1.210924e-03 -1.297427e-03 -1.390319e-03 -1.489971e-03
## ASV4175     -8.386112e-03 -8.629432e-03 -8.876809e-03 -9.128204e-03
## ASV2082     -3.896258e-03 -4.101108e-03 -4.313894e-03 -4.534722e-03
## ASV2272      8.084553e-03  8.374472e-03  8.671821e-03  8.976622e-03
## ASV2245     -8.181151e-03 -8.453006e-03 -8.732002e-03 -9.018270e-03
## ASV0590     -8.603372e-03 -8.957585e-03 -9.323396e-03 -9.701042e-03
## ASV0217      1.861287e-03  2.072035e-03  2.292099e-03  2.521627e-03
## ASV0416      2.419072e-03  2.397938e-03  2.371902e-03  2.340719e-03
## ASV1056      1.151639e-02  1.190727e-02  1.230659e-02  1.271437e-02
## ASV7777     -8.469753e-03 -8.789561e-03 -9.121388e-03 -9.465732e-03
## ASV0455      1.716017e-03  1.743396e-03  1.769035e-03  1.792793e-03
## ASV0604      4.486320e-03  4.676685e-03  4.873199e-03  5.075976e-03
## ASV6100     -8.267157e-03 -8.588104e-03 -8.921003e-03 -9.266278e-03
## ASV11359    -6.897456e-03 -7.082036e-03 -7.268939e-03 -7.458109e-03
## ASV6604      7.465843e-03  7.744788e-03  8.031680e-03  8.326607e-03
## ASV5004     -4.583971e-03 -4.745584e-03 -4.912645e-03 -5.085326e-03
## ASV1483     -4.248068e-03 -4.381575e-03 -4.517777e-03 -4.656635e-03
## ASV9773     -9.918247e-03 -1.027508e-02 -1.064330e-02 -1.102320e-02
## ASV4059      2.961049e-03  3.088042e-03  3.218150e-03  3.351289e-03
## ASV1193      1.428780e-02  1.472095e-02  1.516234e-02  1.561187e-02
## ASV4610      1.025536e-03  1.062121e-03  1.097668e-03  1.132008e-03
## ASV0742     -9.755979e-04 -9.531660e-04 -9.300531e-04 -9.063330e-04
## ASV1502     -1.632611e-03 -1.705597e-03 -1.780421e-03 -1.857051e-03
## ASV0195     -3.495505e-03 -3.645262e-03 -3.800597e-03 -3.961693e-03
## ASV1213      1.720722e-03  1.710175e-03  1.696454e-03  1.679411e-03
## ASV1648     -7.517221e-03 -7.807530e-03 -8.108611e-03 -8.420805e-03
## ASV6984     -6.390977e-03 -6.657904e-03 -6.935652e-03 -7.224605e-03
## ASV0396      2.533464e-03  2.687513e-03  2.844681e-03  3.004737e-03
## ASV4297      4.962001e-03  5.078805e-03  5.197204e-03  5.317200e-03
## ASV2622      1.311653e-02  1.347680e-02  1.384469e-02  1.422035e-02
## ASV3512      7.457705e-03  7.838411e-03  8.236184e-03  8.651614e-03
## ASV2411      8.095413e-03  8.370087e-03  8.649155e-03  8.932333e-03
## ASV2291     -3.868458e-03 -4.038288e-03 -4.213431e-03 -4.393921e-03
## ASV0807      1.142320e-02  1.185011e-02  1.228820e-02  1.273753e-02
## ASV1292      3.555169e-03  3.683512e-03  3.816466e-03  3.954165e-03
## ASV1035      1.248142e-03  1.296012e-03  1.345954e-03  1.398032e-03
## ASV0070      1.632994e-03  1.820265e-03  2.017709e-03  2.225596e-03
## ASV0255     -1.754814e-05 -1.149076e-04 -2.220255e-04 -3.394672e-04
## ASV0057     -8.216399e-03 -8.263000e-03 -8.301435e-03 -8.331334e-03
## ASV0077      1.380391e-03  1.471676e-03  1.563675e-03  1.656015e-03
## ASV0625      1.140598e-02  1.163708e-02  1.186813e-02  1.209896e-02
## ASV2464      5.200675e-03  5.314512e-03  5.429590e-03  5.545917e-03
## ASV1315      2.036622e-02  2.109356e-02  2.183847e-02  2.260087e-02
## ASV2673      1.745612e-02  1.818753e-02  1.894528e-02  1.973002e-02
## ASV2161      7.550672e-03  7.866785e-03  8.193495e-03  8.530947e-03
## ASV0337     -6.052701e-03 -6.213406e-03 -6.376614e-03 -6.542305e-03
## ASV7680     -9.517118e-03 -9.838725e-03 -1.016823e-02 -1.050566e-02
## ASV0611      2.510824e-02  2.608027e-02  2.708319e-02  2.811756e-02
## ASV3118     -7.487357e-03 -7.742132e-03 -8.003024e-03 -8.270056e-03
## ASV1284      7.923645e-03  8.183615e-03  8.448568e-03  8.718416e-03
## ASV0889      5.207069e-03  5.402465e-03  5.605254e-03  5.815702e-03
## ASV4649     -5.421794e-03 -5.595190e-03 -5.772553e-03 -5.953902e-03
## ASV1108     -1.077416e-02 -1.120417e-02 -1.164744e-02 -1.210415e-02
## ASV0738      7.413949e-03  7.853737e-03  8.313963e-03  8.795304e-03
## ASV0473      1.651801e-03  1.724006e-03  1.799367e-03  1.878063e-03
## ASV0598     -3.487838e-03 -3.510707e-03 -3.530219e-03 -3.546166e-03
## ASV0429      1.016092e-02  1.042993e-02  1.070335e-02  1.098125e-02
## ASV1549      1.894180e-02  1.966867e-02  2.041493e-02  2.118052e-02
## ASV1203      8.337061e-03  8.559729e-03  8.784634e-03  9.011614e-03
## ASV4532      5.949658e-04  6.545113e-04  7.190207e-04  7.887672e-04
## ASV0274     -5.167486e-03 -5.274654e-03 -5.383958e-03 -5.495546e-03
## ASV0163     -6.635432e-03 -6.734501e-03 -6.832794e-03 -6.930269e-03
## ASV1298      3.789474e-03  3.923305e-03  4.063586e-03  4.210697e-03
## ASV9424     -1.414104e-02 -1.467194e-02 -1.521982e-02 -1.578508e-02
## ASV0412      1.578688e-02  1.624036e-02  1.670197e-02  1.717169e-02
## ASV0284      4.239292e-03  4.282075e-03  4.320603e-03  4.354524e-03
## ASV0620     -8.619401e-03 -8.939976e-03 -9.269578e-03 -9.608333e-03
## ASV0153     -1.520369e-02 -1.569829e-02 -1.620104e-02 -1.671159e-02
## ASV0498      5.291273e-03  5.471064e-03  5.651609e-03  5.832568e-03
## ASV0097      1.338966e-02  1.392514e-02  1.447735e-02  1.504648e-02
## ASV0104     -3.803274e-02 -3.915654e-02 -4.030163e-02 -4.146795e-02
## ASV1282      7.084429e-03  7.269525e-03  7.454995e-03  7.640566e-03
## ASV3883     -4.985954e-03 -5.122307e-03 -5.258309e-03 -5.393640e-03
## ASV0801      7.125058e-03  7.427952e-03  7.741988e-03  8.067466e-03
## ASV1611     -1.855395e-02 -1.920478e-02 -1.987280e-02 -2.055822e-02
## ASV0227     -9.917758e-03 -1.032991e-02 -1.075670e-02 -1.119855e-02
## ASV0833      9.685036e-03  1.004143e-02  1.040672e-02  1.078092e-02
## ASV0718      1.494729e-02  1.540209e-02  1.586486e-02  1.633544e-02
## ASV1139      7.054066e-05 -4.494936e-05 -1.677003e-04 -2.978844e-04
## ASV0766     -2.840608e-03 -2.917458e-03 -2.996147e-03 -3.076731e-03
## ASV2091      1.277357e-02  1.306026e-02  1.335005e-02  1.364293e-02
## ASV1238      2.347241e-03  2.468404e-03  2.592271e-03  2.718725e-03
## ASV9193     -4.723112e-03 -4.906322e-03 -5.093219e-03 -5.283696e-03
## ASV0290     -2.210228e-03 -2.234167e-03 -2.254239e-03 -2.270176e-03
## ASV0231      1.429032e-02  1.469932e-02  1.511474e-02  1.553647e-02
## ASV0185      1.719681e-02  1.810438e-02  1.905034e-02  2.003573e-02
## ASV2330      3.374244e-03  3.475365e-03  3.579531e-03  3.686830e-03
## ASV3119     -1.077145e-02 -1.124727e-02 -1.174019e-02 -1.225058e-02
## ASV2368     -1.137878e-02 -1.187668e-02 -1.239366e-02 -1.293021e-02
## ASV0122     -3.431516e-03 -3.525403e-03 -3.623179e-03 -3.725151e-03
## ASV1044      1.592177e-02  1.656681e-02  1.723259e-02  1.791945e-02
## ASV0160     -6.139214e-03 -6.214233e-03 -6.288449e-03 -6.361896e-03
## ASV0326      8.500525e-03  8.731455e-03  8.964253e-03  9.198671e-03
## ASV1388      1.521233e-02  1.569356e-02  1.618602e-02  1.668979e-02
## ASV0792      1.340806e-02  1.372359e-02  1.404146e-02  1.436153e-02
## ASV0036     -1.227721e-02 -1.262339e-02 -1.297122e-02 -1.332015e-02
## ASV2125      1.663661e-02  1.709349e-02  1.755556e-02  1.802248e-02
## ASV1075      5.357626e-03  5.571752e-03  5.792667e-03  6.020479e-03
## ASV0390      9.314045e-03  9.788831e-03  1.028468e-02  1.080226e-02
## ASV3790     -1.664133e-02 -1.721178e-02 -1.779703e-02 -1.839723e-02
## ASV1535     -3.152263e-03 -3.283637e-03 -3.418123e-03 -3.555644e-03
## ASV0263      3.389194e-03  3.509481e-03  3.633371e-03  3.760941e-03
## ASV0675      3.279731e-02  3.401427e-02  3.526446e-02  3.654808e-02
## ASV3348      4.785250e-03  5.002420e-03  5.227762e-03  5.461453e-03
## ASV0058     -1.927772e-02 -1.976882e-02 -2.026473e-02 -2.076522e-02
## ASV4142      4.567768e-03  4.695387e-03  4.826051e-03  4.959847e-03
## ASV0059     -1.583317e-02 -1.620943e-02 -1.658769e-02 -1.696770e-02
## ASV0013     -3.915490e-02 -4.034041e-02 -4.155057e-02 -4.278549e-02
## ASV0033     -1.437837e-02 -1.483065e-02 -1.528955e-02 -1.575470e-02
## ASV4354     -4.485247e-03 -4.621188e-03 -4.759703e-03 -4.900722e-03
## ASV0022     -1.440988e-02 -1.482972e-02 -1.525264e-02 -1.567806e-02
## ASV0134     -6.078518e-03 -6.368390e-03 -6.671986e-03 -6.989928e-03
## ASV0415      1.059585e-03  1.148259e-03  1.240388e-03  1.336024e-03
## ASV10103    -9.952353e-03 -1.027326e-02 -1.060064e-02 -1.093443e-02
## ASV1613      1.043564e-02  1.065340e-02  1.087070e-02  1.108736e-02
## ASV0135      6.593175e-03  6.989898e-03  7.404797e-03  7.838383e-03
## ASV0469     -1.456814e-02 -1.498167e-02 -1.540400e-02 -1.583525e-02
## ASV0471      1.268496e-02  1.314599e-02  1.362250e-02  1.411494e-02
## ASV0451     -5.865853e-03 -6.095806e-03 -6.331816e-03 -6.573886e-03
## ASV0747      6.971596e-03  7.213295e-03  7.459737e-03  7.710876e-03
## ASV1314     -1.320461e-02 -1.381990e-02 -1.446048e-02 -1.512712e-02
## ASV0425     -1.246485e-02 -1.271600e-02 -1.296900e-02 -1.322388e-02
## ASV0559     -9.678201e-03 -1.002139e-02 -1.037730e-02 -1.074633e-02
## ASV0148     -5.657556e-03 -5.665765e-03 -5.666232e-03 -5.658584e-03
## ASV0129      1.192900e-03  1.396788e-03  1.611623e-03  1.837600e-03
## ASV1072      2.354479e-03  2.361846e-03  2.368416e-03  2.374342e-03
## ASV2390      1.250057e-03  1.220414e-03  1.187793e-03  1.152162e-03
## ASV0548      1.466566e-02  1.515699e-02  1.566047e-02  1.617621e-02
## ASV0168     -1.710989e-02 -1.762319e-02 -1.814898e-02 -1.868751e-02
## ASV0066     -1.202485e-02 -1.230579e-02 -1.258649e-02 -1.286653e-02
## ASV0468     -6.322111e-03 -6.574501e-03 -6.837040e-03 -7.110109e-03
## ASV0172      3.450640e-03  3.696108e-03  3.952230e-03  4.219190e-03
## ASV0236      8.767870e-04  1.059222e-03  1.249738e-03  1.448298e-03
## ASV0250      1.192986e-02  1.259139e-02  1.328110e-02  1.399967e-02
## ASV0338      2.505383e-03  2.621724e-03  2.740793e-03  2.862560e-03
## ASV0450     -4.827967e-04 -5.333275e-04 -5.879648e-04 -6.469091e-04
## ASV0377      1.526829e-02  1.568965e-02  1.611518e-02  1.654447e-02
## ASV1022      5.835746e-03  6.071673e-03  6.316263e-03  6.569766e-03
## ASV6174     -1.066306e-03 -1.092834e-03 -1.118191e-03 -1.142125e-03
## ASV0786      7.028397e-04  7.102739e-04  7.177083e-04  7.251650e-04
## ASV0053     -1.946385e-02 -2.005689e-02 -2.066133e-02 -2.127713e-02
## ASV0697     -2.493321e-03 -2.521166e-03 -2.549152e-03 -2.577463e-03
## ASV0785      1.487135e-02  1.537845e-02  1.590155e-02  1.644122e-02
## ASV1967     -6.548182e-03 -6.706992e-03 -6.867892e-03 -7.030857e-03
## ASV0385     -1.823371e-03 -1.847206e-03 -1.871361e-03 -1.895869e-03
## ASV0295      6.509860e-03  6.876322e-03  7.258098e-03  7.655482e-03
## ASV0072     -8.454644e-03 -8.546668e-03 -8.633555e-03 -8.715147e-03
## ASV0157      1.035230e-03  1.305969e-03  1.596783e-03  1.908560e-03
## ASV0501      1.093977e-02  1.134972e-02  1.177027e-02  1.220148e-02
## ASV10729    -1.291561e-02 -1.332748e-02 -1.374790e-02 -1.417687e-02
## ASV1470      3.463173e-03  3.507887e-03  3.549944e-03  3.589138e-03
## ASV0050     -3.332541e-02 -3.422896e-02 -3.514549e-02 -3.607476e-02
## ASV0411      1.248963e-03  1.301702e-03  1.352597e-03  1.401151e-03
## ASV0549      1.156174e-02  1.203000e-02  1.251316e-02  1.301136e-02
## ASV0184      5.538109e-03  5.753736e-03  5.976460e-03  6.206416e-03
## ASV0705      5.914167e-03  6.073978e-03  6.234302e-03  6.394887e-03
## ASV1715      1.503976e-02  1.554293e-02  1.605860e-02  1.658687e-02
## ASV0603      3.871473e-03  4.080098e-03  4.298687e-03  4.527545e-03
## ASV0826      2.554873e-03  2.592265e-03  2.628634e-03  2.663887e-03
## ASV0034     -1.200086e-02 -1.223423e-02 -1.246664e-02 -1.269792e-02
## ASV0838      1.556905e-03  1.515024e-03  1.466443e-03  1.410848e-03
## ASV0614     -7.744828e-03 -7.922427e-03 -8.100360e-03 -8.278451e-03
## ASV0014     -3.348557e-02 -3.444048e-02 -3.541249e-02 -3.640158e-02
## ASV0585     -2.266289e-03 -2.311963e-03 -2.356510e-03 -2.399821e-03
## ASV0016     -3.462719e-02 -3.562540e-02 -3.664207e-02 -3.767718e-02
## ASV5394     -9.671030e-03 -9.919252e-03 -1.016631e-02 -1.041151e-02
## ASV0666      7.047322e-03  7.236086e-03  7.427753e-03  7.622316e-03
## ASV2085     -1.884224e-03 -2.036288e-03 -2.195188e-03 -2.361092e-03
## ASV0003     -3.071480e-02 -3.158717e-02 -3.247592e-02 -3.338111e-02
## ASV0346      4.498725e-03  4.722351e-03  4.953115e-03  5.191090e-03
## ASV0267     -1.894318e-03 -1.911758e-03 -1.931153e-03 -1.952883e-03
## ASV0353      1.419380e-02  1.478259e-02  1.538946e-02  1.601454e-02
## ASV2419      8.199690e-03  8.413313e-03  8.628760e-03  8.845810e-03
## ASV0447      1.056102e-02  1.099981e-02  1.145255e-02  1.191953e-02
## ASV0654      1.638079e-02  1.687028e-02  1.736831e-02  1.787488e-02
## ASV0151      8.227481e-03  8.640413e-03  9.069895e-03  9.516308e-03
## ASV0065     -1.200635e-02 -1.231318e-02 -1.262342e-02 -1.293701e-02
## ASV0527      9.429784e-03  9.695791e-03  9.965824e-03  1.023980e-02
## ASV4055     -7.600259e-03 -7.986805e-03 -8.392616e-03 -8.818563e-03
## ASV0166     -7.901939e-03 -8.080592e-03 -8.261550e-03 -8.444878e-03
## ASV0417     -8.638418e-03 -8.896726e-03 -9.161313e-03 -9.432339e-03
## ASV0078     -3.036101e-03 -2.974785e-03 -2.903636e-03 -2.822237e-03
## ASV0322     -5.176262e-03 -5.236366e-03 -5.294264e-03 -5.349906e-03
## ASV0156     -1.051157e-02 -1.082121e-02 -1.113861e-02 -1.146399e-02
## ASV0648     -1.391762e-02 -1.440679e-02 -1.490880e-02 -1.542377e-02
## ASV0407      2.974960e-03  3.120908e-03  3.272560e-03  3.430032e-03
## ASV2030     -2.127093e-03 -2.233177e-03 -2.344997e-03 -2.462768e-03
## ASV0300      1.108133e-02  1.149099e-02  1.190980e-02  1.233761e-02
## ASV1150      1.188223e-03  1.262229e-03  1.338035e-03  1.415488e-03
## ASV0958      1.459652e-02  1.528841e-02  1.600863e-02  1.675795e-02
## ASV0216     -9.550037e-03 -9.873383e-03 -1.020899e-02 -1.055738e-02
## ASV0446      2.271507e-02  2.351701e-02  2.433820e-02  2.517863e-02
## ASV0367     -5.521152e-03 -5.698965e-03 -5.881344e-03 -6.068348e-03
## ASV0200     -1.152001e-02 -1.190931e-02 -1.230857e-02 -1.271785e-02
## ASV0334      3.781027e-04  4.649067e-04  5.539925e-04  6.451984e-04
## ASV1311      5.801380e-03  5.929436e-03  6.056946e-03  6.183676e-03
## ASV0458      8.006823e-03  8.262921e-03  8.525081e-03  8.793360e-03
## ASV1371      4.119138e-04  4.219957e-04  4.318453e-04  4.414370e-04
## ASV0418      1.102093e-02  1.141275e-02  1.181630e-02  1.223185e-02
## ASV0004      1.107133e-02  1.138915e-02  1.171187e-02  1.203934e-02
## ASV1943      7.278932e-03  7.485718e-03  7.696379e-03  7.910937e-03
## ASV1495     -7.053505e-03 -7.402384e-03 -7.765049e-03 -8.141796e-03
## ASV0901     -1.842472e-02 -1.914301e-02 -1.988461e-02 -2.064998e-02
## ASV0628      4.101318e-03  4.095377e-03  4.080377e-03  4.055693e-03
## ASV0400      1.307869e-03  1.266873e-03  1.218607e-03  1.162558e-03
## ASV0116     -1.572758e-02 -1.634401e-02 -1.697897e-02 -1.763268e-02
## ASV0788      8.864466e-03  9.144190e-03  9.430467e-03  9.723461e-03
## ASV0117      1.001160e-02  1.043938e-02  1.088180e-02  1.133909e-02
## ASV3137      1.411184e-03  1.476541e-03  1.546388e-03  1.621091e-03
## ASV0001      8.705502e-03  8.874331e-03  9.043905e-03  9.214246e-03
## ASV1651      7.202813e-03  7.431757e-03  7.669252e-03  7.915743e-03
## ASV1692      1.487566e-02  1.545813e-02  1.605958e-02  1.668049e-02
## ASV0660     -5.180319e-05 -2.204415e-04 -4.011153e-04 -5.941956e-04
## ASV0508     -2.943354e-04 -3.268219e-04 -3.621839e-04 -4.006763e-04
## ASV1660     -6.074105e-03 -6.277184e-03 -6.483316e-03 -6.692282e-03
## ASV0233      5.045684e-03  5.293154e-03  5.551562e-03  5.821305e-03
## ASV1343     -1.230748e-02 -1.276221e-02 -1.323134e-02 -1.371523e-02
## ASV0209      5.815765e-03  5.940447e-03  6.066241e-03  6.193132e-03
## ASV0193     -9.395054e-03 -9.650067e-03 -9.910099e-03 -1.017519e-02
## ASV0357      4.966385e-03  5.295314e-03  5.641345e-03  6.005084e-03
## ASV0198      3.860412e-03  4.029471e-03  4.204936e-03  4.386922e-03
## ASV0007      8.278891e-03  8.440206e-03  8.602266e-03  8.765088e-03
## ASV1772      7.665558e-04  9.118934e-04  1.070792e-03  1.244149e-03
## ASV0009      7.561702e-03  7.704474e-03  7.847947e-03  7.992168e-03
## ASV0006     -1.276283e-04 -2.186502e-04 -3.134613e-04 -4.120084e-04
## ASV0011     -1.760911e-02 -1.823719e-02 -1.888190e-02 -1.954331e-02
## ASV0015      9.057574e-03  9.295727e-03  9.535467e-03  9.776532e-03
## ASV0017      9.651858e-03  9.915846e-03  1.018260e-02  1.045191e-02
## ASV0235     -9.604102e-03 -9.940621e-03 -1.028736e-02 -1.064463e-02
## ASV0382      4.384706e-03  4.491238e-03  4.593433e-03  4.690659e-03
## ASV2357      1.506584e-02  1.561450e-02  1.617861e-02  1.675824e-02
## ASV0567     -9.487641e-03 -9.843986e-03 -1.021262e-02 -1.059382e-02
## ASV0165      1.004622e-02  1.036884e-02  1.069983e-02  1.103938e-02
## ASV0005      1.534490e-02  1.569010e-02  1.603633e-02  1.638335e-02
## ASV0384      4.623180e-03  4.960189e-03  5.316698e-03  5.693507e-03
## ASV0002      7.626756e-03  7.938617e-03  8.259596e-03  8.589713e-03
## ASV3017      8.802116e-03  9.028597e-03  9.258802e-03  9.492747e-03
## ASV0091      5.686453e-03  5.861417e-03  6.037597e-03  6.214652e-03
## ASV0186     -1.231113e-02 -1.264916e-02 -1.298985e-02 -1.333288e-02
## ASV0370      2.895309e-03  3.049735e-03  3.211589e-03  3.381118e-03
## ASV0018      1.694447e-02  1.736256e-02  1.778460e-02  1.821045e-02
## ASV1377      1.539417e-02  1.582108e-02  1.625579e-02  1.669836e-02
## ASV0019      1.716893e-02  1.760137e-02  1.803858e-02  1.848045e-02
## ASV0023     -3.378792e-03 -3.555018e-03 -3.735816e-03 -3.921085e-03
## ASV2194      9.845786e-03  1.023131e-02  1.062863e-02  1.103788e-02
## ASV1155      1.939512e-03  2.050295e-03  2.165239e-03  2.284434e-03
## ASV0510     -2.477839e-03 -2.482727e-03 -2.486423e-03 -2.488929e-03
## ASV2371     -4.374032e-03 -4.453923e-03 -4.533562e-03 -4.612916e-03
## ASV0024     -4.473537e-03 -4.687698e-03 -4.907582e-03 -5.133127e-03
## ASV2452      5.451640e-03  5.536440e-03  5.620725e-03  5.704494e-03
## ASV2332      4.473489e-03  4.672100e-03  4.876334e-03  5.086188e-03
## ASV2591      3.945580e-03  4.108215e-03  4.274688e-03  4.444951e-03
## ASV0521      1.900248e-02  1.974081e-02  2.050288e-02  2.128921e-02
## ASV5542      6.008474e-03  6.225927e-03  6.449317e-03  6.678727e-03
## ASV0336     -6.480432e-03 -6.721349e-03 -6.972076e-03 -7.233092e-03
## ASV10102     1.052605e-02  1.084938e-02  1.117777e-02  1.151104e-02
## ASV16823    -4.149544e-03 -4.237459e-03 -4.326432e-03 -4.416481e-03
## ASV3104      4.148946e-03  4.236812e-03  4.325731e-03  4.415723e-03
## ASV0781      3.067868e-03  3.171597e-03  3.279052e-03  3.390360e-03
## ASV10899     8.222973e-03  8.583089e-03  8.955408e-03  9.340124e-03
## ASV11222    -4.148200e-03 -4.236003e-03 -4.324854e-03 -4.414772e-03
## ASV11327    -4.147664e-03 -4.235426e-03 -4.324232e-03 -4.414103e-03
## ASV12458    -4.147163e-03 -4.234887e-03 -4.323654e-03 -4.413482e-03
## ASV1636     -3.118479e-03 -3.184731e-03 -3.252309e-03 -3.321270e-03
## ASV1890     -5.835955e-03 -6.038516e-03 -6.248785e-03 -6.467075e-03
## ASV2898      1.287465e-02  1.323480e-02  1.360298e-02  1.397939e-02
## ASV8328      4.176802e-03  4.417228e-03  4.667096e-03  4.926526e-03
## ASV0709     -1.053885e-02 -1.081728e-02 -1.110030e-02 -1.138797e-02
## ASV0856      4.013206e-03  4.172613e-03  4.336354e-03  4.504427e-03
## ASV0909      9.419805e-04  1.086552e-03  1.238139e-03  1.396863e-03
## ASV0937     -1.333096e-02 -1.386554e-02 -1.441835e-02 -1.498970e-02
## ASV11390    -4.145807e-03 -4.233435e-03 -4.322100e-03 -4.411821e-03
## ASV11966     6.529955e-03  6.777791e-03  7.032095e-03  7.292869e-03
## ASV12990     2.026955e-03  2.090256e-03  2.155033e-03  2.221278e-03
## ASV14797     5.215938e-03  5.348209e-03  5.483035e-03  5.620444e-03
## ASV14904    -4.145081e-03 -4.232668e-03 -4.321294e-03 -4.410976e-03
## ASV15304     5.106318e-03  5.313412e-03  5.526147e-03  5.744520e-03
## ASV16696    -4.144741e-03 -4.232316e-03 -4.320928e-03 -4.410599e-03
## ASV1690      6.365615e-03  6.572431e-03  6.782214e-03  6.994825e-03
## ASV2029      1.848369e-02  1.902830e-02  1.958345e-02  2.014912e-02
## ASV2834      1.196095e-02  1.235244e-02  1.275236e-02  1.316061e-02
## ASV4003      9.470151e-03  9.944268e-03  1.043962e-02  1.095700e-02
## ASV4064      9.129725e-03  9.442400e-03  9.763618e-03  1.009357e-02
## ASV4294      7.256829e-03  7.594899e-03  7.945469e-03  8.308765e-03
## ASV4609      7.953908e-04  8.432139e-04  8.930216e-04  9.448431e-04
## ASV6283     -4.144140e-03 -4.231692e-03 -4.320282e-03 -4.409930e-03
## ASV6491     -4.144031e-03 -4.231584e-03 -4.320177e-03 -4.409828e-03
## ASV7453      6.742750e-03  7.013590e-03  7.291597e-03  7.576753e-03
## ASV7959      4.456879e-03  4.675472e-03  4.902455e-03  5.138028e-03
## ASV8219      4.143985e-03  4.231556e-03  4.320170e-03  4.409846e-03
## ASV8547     -4.144005e-03 -4.231590e-03 -4.320218e-03 -4.409911e-03
## ASV9319      7.397809e-03  7.708531e-03  8.031255e-03  8.366373e-03
## ASV9382     -4.144076e-03 -4.231684e-03 -4.320339e-03 -4.410062e-03
## ASV11516    -4.144196e-03 -4.231826e-03 -4.320506e-03 -4.410256e-03
## ASV14377    -4.144351e-03 -4.232006e-03 -4.320713e-03 -4.410494e-03
## ASV1867      1.299479e-02  1.345789e-02  1.393472e-02  1.442557e-02
## ASV1895     -1.751243e-03 -1.816855e-03 -1.885215e-03 -1.956413e-03
## ASV3168      2.352573e-03  2.376155e-03  2.398600e-03  2.419880e-03
## ASV4449      7.254932e-03  7.480996e-03  7.713673e-03  7.953159e-03
## ASV6596      1.090578e-02  1.138584e-02  1.188257e-02  1.239621e-02
## ASV7492      1.502371e-03  1.614765e-03  1.731083e-03  1.851285e-03
## ASV9854     -1.700747e-03 -1.726968e-03 -1.753172e-03 -1.779376e-03
## ASV6296      4.145191e-03  4.232965e-03  4.321803e-03  4.411727e-03
## ASV4201      8.852019e-03  9.276669e-03  9.717746e-03  1.017566e-02
## ASV0552      2.141283e-02  2.209718e-02  2.279300e-02  2.349986e-02
## ASV3671      6.017062e-04  6.226726e-04  6.424041e-04  6.607428e-04
## ASV3529      1.599407e-03  1.673473e-03  1.748400e-03  1.824074e-03
## ASV1060      7.789984e-03  8.162405e-03  8.551845e-03  8.958970e-03
## ASV0239     -4.812067e-03 -4.856805e-03 -4.898371e-03 -4.936591e-03
## ASV5711     -6.857012e-03 -7.037585e-03 -7.221193e-03 -7.407833e-03
## ASV4152     -1.088486e-02 -1.118904e-02 -1.149784e-02 -1.181116e-02
## ASV1461      6.328087e-03  6.452681e-03  6.578307e-03  6.704958e-03
## ASV2877      6.800231e-03  6.940395e-03  7.079360e-03  7.216892e-03
## ASV0012      1.049314e-02  1.089525e-02  1.130827e-02  1.173226e-02
## ASV9823      3.723901e-04  3.532125e-04  3.336421e-04  3.137754e-04
## ASV0008      1.093412e-02  1.135139e-02  1.178018e-02  1.222054e-02
## ASV7832     -6.598055e-03 -6.796364e-03 -6.998969e-03 -7.205894e-03
## ASV1915      1.327037e-03  1.349042e-03  1.369457e-03  1.388156e-03
## ASV0055      4.128359e-03  4.192722e-03  4.252843e-03  4.308239e-03
## ASV0032      9.922650e-03  1.021354e-02  1.051331e-02  1.082239e-02
## ASV2977     -8.924213e-03 -9.163637e-03 -9.406128e-03 -9.651612e-03
## ASV0466      6.420065e-03  6.527487e-03  6.633117e-03  6.736810e-03
## ASV3866      1.429041e-02  1.485771e-02  1.544607e-02  1.605619e-02
## ASV0040      1.962750e-02  2.033391e-02  2.105841e-02  2.180108e-02
## ASV0496     -5.431062e-03 -5.693484e-03 -5.964890e-03 -6.245359e-03
## ASV0052      1.527488e-02  1.567854e-02  1.608797e-02  1.650312e-02
## ASV3828     -1.088843e-02 -1.127723e-02 -1.167935e-02 -1.209526e-02
## ASV1930      5.989358e-03  6.139310e-03  6.290874e-03  6.444009e-03
## ASV2126      1.025006e-02  1.054103e-02  1.083686e-02  1.113751e-02
## ASV0793      1.165712e-02  1.212148e-02  1.260079e-02  1.309544e-02
## ASV0299     -2.385856e-03 -2.486132e-03 -2.593483e-03 -2.708342e-03
## ASV0208      1.646341e-02  1.714765e-02  1.785595e-02  1.858884e-02
## ASV0511     -5.367777e-04 -4.868391e-04 -4.353828e-04 -3.825127e-04
## ASV1123     -3.475271e-03 -3.503327e-03 -3.528117e-03 -3.549392e-03
## ASV0099     -3.017105e-04 -1.576661e-04 -8.324804e-07  1.693768e-04
## ASV0752     -2.356391e-03 -2.452362e-03 -2.551305e-03 -2.653277e-03
## ASV0883      1.183016e-03  1.235984e-03  1.290616e-03  1.346950e-03
## ASV0683      1.306756e-02  1.354506e-02  1.403440e-02  1.453549e-02
## ASV4117     -1.062107e-02 -1.096588e-02 -1.131952e-02 -1.168213e-02
## ASV2172      4.728459e-03  4.896140e-03  5.068801e-03  5.246558e-03
## ASV0330     -8.337831e-03 -8.622595e-03 -8.915893e-03 -9.218000e-03
## ASV0728      9.752697e-03  1.011044e-02  1.047910e-02  1.085895e-02
## ASV0499      2.128222e-02  2.212552e-02  2.299480e-02  2.389033e-02
## ASV0120     -1.414669e-02 -1.451574e-02 -1.488819e-02 -1.526378e-02
## ASV1446     -2.951761e-03 -3.175302e-03 -3.411943e-03 -3.662230e-03
## ASV17171    -1.087220e-02 -1.125063e-02 -1.163994e-02 -1.204027e-02
## ASV0533      5.229198e-03  5.443403e-03  5.663853e-03  5.890530e-03
## ASV2495     -7.136285e-03 -7.432162e-03 -7.737092e-03 -8.051119e-03
## ASV5582      9.385682e-04  9.122977e-04  8.827652e-04  8.497759e-04
## ASV1488      4.501940e-03  4.645403e-03  4.791129e-03  4.939049e-03
## ASV0682      1.410333e-02  1.462961e-02  1.516971e-02  1.572362e-02
## ASV0068     -3.016139e-03 -3.114354e-03 -3.212345e-03 -3.309915e-03
## ASV1987     -1.036890e-02 -1.081822e-02 -1.128346e-02 -1.176493e-02
## ASV0035     -7.312319e-03 -7.827402e-03 -8.369850e-03 -8.940572e-03
## ASV7192     -3.810192e-03 -3.853308e-03 -3.894154e-03 -3.932645e-03
## ASV0873     -7.282330e-04 -7.590234e-04 -7.895275e-04 -8.196277e-04
## ASV4749     -5.624152e-03 -5.941508e-03 -6.271937e-03 -6.615717e-03
## ASV2174      4.316699e-03  4.462941e-03  4.616418e-03  4.777519e-03
## ASV1476     -7.669718e-03 -7.958366e-03 -8.255354e-03 -8.560783e-03
## ASV0740     -1.984176e-02 -2.058545e-02 -2.135049e-02 -2.213711e-02
## ASV0170      3.588191e-03  3.722658e-03  3.861767e-03  4.005679e-03
## ASV2466     -1.492802e-02 -1.547763e-02 -1.604415e-02 -1.662784e-02
## ASV1709      9.088809e-03  9.347735e-03  9.611117e-03  9.878952e-03
## ASV6170     -1.095275e-02 -1.132324e-02 -1.170251e-02 -1.209057e-02
## ASV3673      1.280175e-02  1.324166e-02  1.369233e-02  1.415382e-02
## ASV1745      7.435498e-04  7.517463e-04  7.586683e-04  7.642059e-04
##                                                                    
## (Intercept) -0.0188468117 -0.0199111443 -0.0210183070 -0.0221715616
## ASV1236      0.0058950839  0.0060338754  0.0061746752  0.0063444081
## ASV0421     -0.0109361995 -0.0112002406 -0.0114686765 -0.0117295481
## ASV0691     -0.0072721355 -0.0074223251 -0.0075742747 -0.0077191410
## ASV0899      0.0006588697  0.0006690796  0.0006792844  0.0006984152
## ASV1004      0.0118036365  0.0120508910  0.0122997805  0.0125496420
## ASV1041     -0.0073193208 -0.0074461440 -0.0075725902 -0.0077076560
## ASV1058      0.0122343534  0.0125445531  0.0128597098  0.0131771291
## ASV12542     0.0025725480  0.0026303892  0.0026896686  0.0027386512
## ASV1294      0.0155639541  0.0159792384  0.0164022345  0.0168401796
## ASV13113     0.0114730439  0.0119471186  0.0124374660  0.0129375288
## ASV1318      0.0118899956  0.0121704514  0.0124546440  0.0127619066
## ASV2269     -0.0033207662 -0.0033896717 -0.0034589714 -0.0035535976
## ASV2542      0.0142253511  0.0147313892  0.0152504825  0.0157892233
## ASV2660     -0.0058644742 -0.0059900766 -0.0061172169 -0.0062662634
## ASV2737     -0.0009360668 -0.0009573566 -0.0009784081 -0.0010179012
## ASV2840      0.0064837003  0.0065791627  0.0066740519  0.0067662176
## ASV3053      0.0005729056  0.0005989589  0.0006261312  0.0006405446
## ASV3077      0.0029675154  0.0030511299  0.0031366104  0.0032146748
## ASV3134      0.0218154063  0.0226978530  0.0236098080  0.0245470437
## ASV3140      0.0066645767  0.0068631545  0.0070649903  0.0072822609
## ASV3579      0.0063814705  0.0066335856  0.0068913888  0.0071444405
## ASV6119     -0.0033220018 -0.0033905675 -0.0034593984 -0.0035407839
## ASV7557     -0.0033223682 -0.0033909058 -0.0034597042 -0.0035392190
## ASV8422      0.0017241284  0.0017727636  0.0018228296  0.0018676076
## ASV1086     -0.0010441446 -0.0010815768 -0.0011203399 -0.0011566099
## ASV1310      0.0066246923  0.0067355623  0.0068440037  0.0069475054
## ASV15750    -0.0008979023 -0.0008936085 -0.0008877379 -0.0008856969
## ASV16905    -0.0033251703 -0.0033937641 -0.0034626220 -0.0035365454
## ASV2033      0.0122155719  0.0126276639  0.0130500342  0.0134819175
## ASV2089      0.0022454519  0.0022872741  0.0023289309  0.0023732414
## ASV2127      0.0103386010  0.0105906189  0.0108455492  0.0111031215
## ASV2725      0.0089443901  0.0091199702  0.0092973565  0.0094770327
## ASV2804     -0.0033268178 -0.0033954343 -0.0034643293 -0.0035358576
## ASV3075      0.0109812548  0.0113864966  0.0118042337  0.0122336565
## ASV3327      0.0119066701  0.0123259333  0.0127565106  0.0131994742
## ASV3342      0.0110428096  0.0113995857  0.0117647413  0.0121398086
## ASV3532     -0.0111336018 -0.0115635381 -0.0120088869 -0.0124719567
## ASV3600      0.0122892466  0.0126784705  0.0130761166  0.0134824903
## ASV4013      0.0072691550  0.0074294580  0.0075902943  0.0077533225
## ASV4136      0.0068146848  0.0069913137  0.0071711698  0.0073556660
## ASV4195      0.0033288862  0.0033976315  0.0034666990  0.0035356096
## ASV4407     -0.0033291935 -0.0033979444 -0.0034670245 -0.0035356663
## ASV4717     -0.0002237875 -0.0002227424 -0.0002208873 -0.0002164364
## ASV6794      0.0034643616  0.0035695760  0.0036778884  0.0037928497
## ASV8324     -0.0033310154 -0.0033998634 -0.0034690511 -0.0035365487
## ASV8981      0.0015021700  0.0016000330  0.0017012215  0.0018072622
## ASV9859      0.0098210120  0.0102991912  0.0107974619  0.0113161699
## ASV0936     -0.0063512740 -0.0065207437 -0.0066931486 -0.0068723692
## ASV12683    -0.0009465403 -0.0009636669 -0.0009802812 -0.0009937966
## ASV1293      0.0080708234  0.0082655099  0.0084633603  0.0086649835
## ASV13055     0.0001250177  0.0001593330  0.0001958712  0.0002362090
## ASV17063    -0.0033314185 -0.0034002373 -0.0034694207 -0.0035377245
## ASV2228      0.0033317528  0.0034006548  0.0034699417  0.0035379348
## ASV2769      0.0005630324  0.0005824739  0.0006012254  0.0006211547
## ASV2803      0.0012586273  0.0012935889  0.0013297375  0.0013704362
## ASV2896      0.0098155924  0.0102800996  0.0107665840  0.0112792332
## ASV3062      0.0050975808  0.0053050244  0.0055178453  0.0057387982
## ASV3107      0.0086573590  0.0089489621  0.0092476673  0.0095571741
## ASV3265      0.0098976831  0.0101044247  0.0103119898  0.0105215153
## ASV3666     -0.0009404258 -0.0009820494 -0.0010248908 -0.0010650271
## ASV4497      0.0026534333  0.0027234791  0.0027949854  0.0028741060
## ASV6914     -0.0017630607 -0.0018141655 -0.0018662640 -0.0019144752
## ASV0576     -0.0103088867 -0.0105382060 -0.0107710108 -0.0110138454
## ASV0673      0.0054674865  0.0056208200  0.0057767701  0.0059342224
## ASV0772      0.0055786063  0.0057656393  0.0059576691  0.0061587757
## ASV0862     -0.0011140911 -0.0011130774 -0.0011121136 -0.0011176495
## ASV0898      0.0063978684  0.0066114028  0.0068300631  0.0070491395
## ASV0910      0.0138336294  0.0143384010  0.0148576655  0.0153930201
## ASV0964     -0.0035065118 -0.0035685290 -0.0036308431 -0.0036998795
## ASV10059     0.0079321898  0.0082647632  0.0086093270  0.0089717857
## ASV10263    -0.0033403003 -0.0034103869 -0.0034810101 -0.0035458560
## ASV1088      0.0092781396  0.0096712395  0.0100777765  0.0104974540
## ASV1101      0.0055803763  0.0056494772  0.0057151840  0.0057771540
## ASV1183      0.0055836007  0.0057567305  0.0059340170  0.0061083132
## ASV11956     0.0009066642  0.0009316086  0.0009575280  0.0009916748
## ASV12774    -0.0012637908 -0.0013092278 -0.0013559208 -0.0013957656
## ASV1321      0.0059228404  0.0061570511  0.0063968881  0.0066473392
## ASV13793    -0.0033451638 -0.0034161260 -0.0034877443 -0.0035505150
## ASV14482    -0.0005196460 -0.0005244627 -0.0005288646 -0.0005231012
## ASV15483     0.0043062298  0.0044575266  0.0046133904  0.0047841752
## ASV2062      0.0196663141  0.0202072668  0.0207568747  0.0213146014
## ASV2132      0.0121426569  0.0125463008  0.0129590934  0.0133904055
## ASV2413      0.0113208389  0.0116321087  0.0119496723  0.0122806048
## ASV2490      0.0054735387  0.0055811804  0.0056897059  0.0057996182
## ASV2594      0.0072728144  0.0075856915  0.0079105411  0.0082587423
## ASV2822     -0.0033518032 -0.0034236411 -0.0034961982 -0.0035572598
## ASV2863      0.0061611772  0.0063172394  0.0064761526  0.0066291821
## ASV2910      0.0077391983  0.0079337809  0.0081325089  0.0083470685
## ASV2980      0.0022721150  0.0023077402  0.0023432543  0.0023646343
## ASV3307      0.0033578240  0.0034304109  0.0035037665  0.0035637090
## ASV3474      0.0111018741  0.0114698199  0.0118446647  0.0122330592
## ASV3502      0.0165450122  0.0170961912  0.0176634403  0.0182542955
## ASV4236      0.0049356856  0.0050402649  0.0051461494  0.0052631754
## ASV4842     -0.0016932326 -0.0017191352 -0.0017447462 -0.0017547021
## ASV4894     -0.0033630591 -0.0034361844 -0.0035101029 -0.0035697109
## ASV5290      0.0051407024  0.0052652606  0.0053913613  0.0055265650
## ASV5501      0.0019217700  0.0020110403  0.0021037741  0.0022147155
## ASV5795      0.0052673509  0.0054359932  0.0056075821  0.0057952723
## ASV5987     -0.0033683466 -0.0034419893 -0.0035164514 -0.0035758253
## ASV6267     -0.0033702823 -0.0034441145 -0.0035187771 -0.0035781279
## ASV6862      0.0057286489  0.0058646503  0.0060031826  0.0061512252
## ASV7145      0.0015566630  0.0016183131  0.0016820930  0.0017628090
## ASV7673     -0.0033740010 -0.0034481490 -0.0035231405 -0.0035824158
## ASV7789      0.0058971515  0.0061643416  0.0064405686  0.0067410470
## ASV7809      0.0012923235  0.0013540959  0.0014171127  0.0014973375
## ASV8002     -0.0033796797 -0.0034543402 -0.0035298716 -0.0035889029
## ASV8205      0.0036200727  0.0037506741  0.0038846319  0.0040378765
## ASV9155     -0.0022320280 -0.0022720492 -0.0023120502 -0.0023342337
## ASV9221      0.0023439223  0.0024789050  0.0026194732  0.0027815043
## ASV9311     -0.0033872153 -0.0034624241 -0.0035385178 -0.0035979862
## ASV9557     -0.0033891159 -0.0034644419 -0.0035406544 -0.0036004896
## ASV9936     -0.0033909681 -0.0034664038 -0.0035427276 -0.0036029565
## ASV1445      0.0139309312  0.0144187070  0.0149198072  0.0154435423
## ASV4232      0.0166960184  0.0174208008  0.0181728035  0.0189624988
## ASV6479      0.0042934069  0.0045166458  0.0047480664  0.0050024326
## ASV0142     -0.0163933622 -0.0167589220 -0.0171286721 -0.0175136878
## ASV0378     -0.0026252915 -0.0026036486 -0.0025787946 -0.0025605265
## ASV1122      0.0172483032  0.0177964316  0.0183561133  0.0189374224
## ASV0123     -0.0157849943 -0.0161268343 -0.0164719725 -0.0168321632
## ASV2064      0.0009124435  0.0009340464  0.0009571379  0.0009973312
## ASV4459     -0.0018310911 -0.0018823748 -0.0019351719 -0.0019751266
## ASV0448      0.0093541764  0.0097257115  0.0101073304  0.0104865656
## ASV0397      0.0113922966  0.0117310027  0.0120761962  0.0124154185
## ASV0485      0.0154372862  0.0159310709  0.0164375340  0.0169453829
## ASV1566      0.0130210454  0.0134056919  0.0137982398  0.0142067553
## ASV1365      0.0083164115  0.0085352050  0.0087563131  0.0089890442
## ASV1065      0.0183504292  0.0189152842  0.0194915375  0.0200753060
## ASV0722     -0.0004932249 -0.0005359536 -0.0005817697 -0.0006435113
## ASV12660    -0.0051259346 -0.0052370962 -0.0053496908 -0.0054464431
## ASV0223      0.0009511366  0.0010260978  0.0011050281  0.0011737312
## ASV0229      0.0105073532  0.0108964385  0.0112974431  0.0116973688
## ASV0877     -0.0013060091 -0.0013431365 -0.0013823091 -0.0014139864
## ASV0983      0.0132180043  0.0135653815  0.0139180824  0.0142713369
## ASV0626     -0.0008201829 -0.0008074190 -0.0007948975 -0.0007783997
## ASV4146     -0.0015967641 -0.0017110889 -0.0018333450 -0.0019500376
## ASV4175     -0.0093835771 -0.0096428895 -0.0099061032 -0.0101592274
## ASV2082     -0.0047636865 -0.0050008712 -0.0052463472 -0.0055101224
## ASV2272      0.0092888864  0.0096086205  0.0099358205  0.0102784979
## ASV2245     -0.0093119417 -0.0096131527 -0.0099220378 -0.0102285043
## ASV0590     -0.0100907624 -0.0104927951 -0.0109073800 -0.0113418066
## ASV0217      0.0027607675  0.0030096657  0.0032684672  0.0035276296
## ASV0416      0.0023041351  0.0022618920  0.0022137229  0.0021508178
## ASV1056      0.0131305889  0.0135552626  0.0139883937  0.0144349510
## ASV7777     -0.0098231135 -0.0101940768 -0.0105791877 -0.0109711885
## ASV0455      0.0018145331  0.0018341161  0.0018514028  0.0018582932
## ASV0604      0.0052851306  0.0055007733  0.0057230144  0.0059547555
## ASV6100     -0.0096243644 -0.0099957074 -0.0103807643 -0.0107744620
## ASV11359    -0.0076494890 -0.0078430237 -0.0080386562 -0.0082311851
## ASV6604      0.0086296523  0.0089409000  0.0092604318  0.0095904685
## ASV5004     -0.0052637984 -0.0054482342 -0.0056388065 -0.0058324081
## ASV1483     -0.0047981029 -0.0049421268 -0.0050886456 -0.0052362473
## ASV9773     -0.0114150811 -0.0118192441 -0.0122359884 -0.0126651312
## ASV4059      0.0034873652  0.0036262718  0.0037678933  0.0039100255
## ASV1193      0.0160694591  0.0165350152  0.0170084269  0.0174933118
## ASV4610      0.0011649700  0.0011963840  0.0012260785  0.0012567662
## ASV0742     -0.0008820770 -0.0008573537 -0.0008322272 -0.0008114779
## ASV1502     -0.0019354472 -0.0020155671 -0.0020973629 -0.0021821297
## ASV0195     -0.0041287356 -0.0043019164 -0.0044814308 -0.0046696993
## ASV1213      0.0016588973  0.0016347618  0.0016068523  0.0015807273
## ASV1648     -0.0087444559 -0.0090799092 -0.0094275090 -0.0097923364
## ASV6984     -0.0075251512 -0.0078376859 -0.0081626087 -0.0085020407
## ASV0396      0.0031674273  0.0033324844  0.0034996211  0.0036636854
## ASV4297      0.0054387945  0.0055619890  0.0056867841  0.0058159167
## ASV2622      0.0146039410  0.0149956113  0.0153955231  0.0158075290
## ASV3512      0.0090853039  0.0095378610  0.0100099020  0.0104962321
## ASV2411      0.0092193187  0.0095097864  0.0098033896  0.0101011455
## ASV2291     -0.0045797872 -0.0047710533 -0.0049677359 -0.0051637232
## ASV0807      0.0131981660  0.0136701690  0.0141535868  0.0146456117
## ASV1292      0.0040967427  0.0042443298  0.0043970541  0.0045570167
## ASV1035      0.0014523085  0.0015088419  0.0015676892  0.0016296478
## ASV0070      0.0024441902  0.0026737504  0.0029145306  0.0031665948
## ASV0255     -0.0004678106 -0.0006076448 -0.0007595692 -0.0009201994
## ASV0057     -0.0083523373 -0.0083640878 -0.0083662378 -0.0083590062
## ASV0077      0.0017482858  0.0018400447  0.0019308134  0.0020205696
## ASV0625      0.0123293889  0.0125592415  0.0127883411  0.0130227870
## ASV2464      0.0056635026  0.0057823577  0.0059024956  0.0060290025
## ASV1315      0.0233806337  0.0241775884  0.0249915378  0.0258164218
## ASV2673      0.0205424018  0.0213830583  0.0222526275  0.0231481505
## ASV2161      0.0088792712  0.0092385841  0.0096089880  0.0099848438
## ASV0337     -0.0067104514 -0.0068810199 -0.0070539712 -0.0072234457
## ASV7680     -0.0108510137 -0.0112042899 -0.0115654748 -0.0119462838
## ASV0611      0.0291838988  0.0302827130  0.0314144927  0.0325726864
## ASV3118     -0.0085432450 -0.0088226070 -0.0091081549 -0.0094095844
## ASV1284      0.0089930630  0.0092724087  0.0095563498  0.0098491288
## ASV0889      0.0060340744  0.0062606430  0.0064956788  0.0067349941
## ASV4649     -0.0061392533 -0.0063286199 -0.0065220142 -0.0067278911
## ASV1108     -0.0125744577 -0.0130585185 -0.0135564811 -0.0140753111
## ASV0738      0.0092984468  0.0098240877  0.0103729313  0.0109445916
## ASV0473      0.0019602906  0.0020462581  0.0021361922  0.0022360214
## ASV0598     -0.0035583363 -0.0035665083 -0.0035704571 -0.0035751636
## ASV0429      0.0112636744  0.0115506997  0.0118424000  0.0121379286
## ASV1549      0.0219653366  0.0227692271  0.0235920101  0.0244310278
## ASV1203      0.0092404974  0.0094711086  0.0097032635  0.0099440458
## ASV4532      0.0008640266  0.0009450756  0.0010321908  0.0011208612
## ASV0274     -0.0056095740 -0.0057262062 -0.0058456160 -0.0059702050
## ASV0163     -0.0070268833 -0.0071225920 -0.0072173497 -0.0073117376
## ASV1298      0.0043650342  0.0045270113  0.0046970583  0.0048817738
## ASV9424     -0.0163680936 -0.0169692569 -0.0175889601 -0.0182377554
## ASV0412      0.0176495345  0.0181355000  0.0186295937  0.0191365019
## ASV0284      0.0043834713  0.0044070662  0.0044249166  0.0044426682
## ASV0620     -0.0099563699 -0.0103138118 -0.0106807832 -0.0110636931
## ASV0153     -0.0172295406 -0.0177544633 -0.0182859065 -0.0188211200
## ASV0498      0.0060135868  0.0061943018  0.0063743394  0.0065558534
## ASV0097      0.0156327213  0.0162362523  0.0168572245  0.0174988447
## ASV0104     -0.0426554587 -0.0438640730 -0.0450937105 -0.0463552618
## ASV1282      0.0078259570  0.0080108783  0.0081950330  0.0083674381
## ASV3883     -0.0055279610 -0.0056609160 -0.0057921328 -0.0059279909
## ASV0801      0.0084046837  0.0087539406  0.0091155334  0.0094995508
## ASV1611     -0.0212611837 -0.0219818775 -0.0227204592 -0.0234844649
## ASV0227     -0.0116559044 -0.0121292158 -0.0126189516 -0.0131213987
## ASV0833      0.0111640154  0.0115560076  0.0119568749  0.0123635719
## ASV0718      0.0168136879  0.0172994495  0.0177925492  0.0182937080
## ASV1139     -0.0004356713 -0.0005812285 -0.0007347216 -0.0008882912
## ASV0766     -0.0031592669 -0.0032438167 -0.0033304434 -0.0034297359
## ASV2091      0.0139388853  0.0142378868  0.0145399125  0.0148519373
## ASV1238      0.0028476458  0.0029789051  0.0031123721  0.0032325999
## ASV9193     -0.0054776446 -0.0056749509 -0.0058754993 -0.0060771460
## ASV0290     -0.0022817109 -0.0022885818 -0.0022905305 -0.0022872868
## ASV0231      0.0159644251  0.0163984927  0.0168385801  0.0172881886
## ASV0185      0.0210616323  0.0221290959  0.0232391878  0.0243884457
## ASV2330      0.0037973432  0.0039111509  0.0040283270  0.0041445898
## ASV3119     -0.0127788192 -0.0133252905 -0.0138903615 -0.0144786083
## ASV2368     -0.0134867891 -0.0140638536 -0.0146618453 -0.0152881869
## ASV0122     -0.0038316486 -0.0039430214 -0.0040596401 -0.0041816882
## ASV1044      0.0186277119  0.0193576881  0.0201096703  0.0208807290
## ASV0160     -0.0064346076 -0.0065066160 -0.0065779500 -0.0066506606
## ASV0326      0.0094344496  0.0096713171  0.0099089883  0.0101454446
## ASV1388      0.0172049645  0.0177316043  0.0182697814  0.0188238058
## ASV0792      0.0146836688  0.0150077555  0.0153336589  0.0156649960
## ASV0036     -0.0136696012 -0.0140189722 -0.0143676414 -0.0147142813
## ASV2125      0.0184939102  0.0189694776  0.0194487997  0.0199316873
## ASV1075      0.0062552946  0.0064972144  0.0067463368  0.0069985139
## ASV0390      0.0113422236  0.0119052484  0.0124919889  0.0131055326
## ASV3790     -0.0190125259 -0.0196430600 -0.0202889616 -0.0209576597
## ASV1535     -0.0036961170 -0.0038394510 -0.0039855495 -0.0041376785
## ASV0263      0.0038922639  0.0040274109  0.0041664514  0.0043160697
## ASV0675      0.0378652878  0.0392162005  0.0406009005  0.0420182922
## ASV3348      0.0057036697  0.0059545795  0.0062143445  0.0064772788
## ASV0058     -0.0212700487 -0.0217789765 -0.0222917489 -0.0228087031
## ASV4142      0.0050968645  0.0052371946  0.0053809317  0.0055293997
## ASV0059     -0.0173492024 -0.0177319380 -0.0181156420 -0.0184999686
## ASV0013     -0.0440452690 -0.0453300296 -0.0466398721 -0.0479851525
## ASV0033     -0.0162257293 -0.0167022435 -0.0171838226 -0.0176669898
## ASV4354     -0.0050441641 -0.0051899420 -0.0053379594 -0.0054929278
## ASV0022     -0.0161053174 -0.0165337551 -0.0169626649 -0.0173861296
## ASV0134     -0.0073228575 -0.0076714364 -0.0080363467 -0.0084148742
## ASV0415      0.0014352220  0.0015380350  0.0016445196  0.0017574581
## ASV10103    -0.0112745735 -0.0116209902 -0.0119735983 -0.0123404088
## ASV1613      0.0113032106  0.0115180884  0.0117318446  0.0119428729
## ASV0135      0.0082911604  0.0087636323  0.0092562939  0.0097730305
## ASV0469     -0.0162755191 -0.0167249131 -0.0171835351 -0.0176493694
## ASV0471      0.0146238179  0.0151496052  0.0156928027  0.0162503643
## ASV0451     -0.0068220228 -0.0070762275 -0.0073365027 -0.0075941738
## ASV0747      0.0079666713  0.0082270874  0.0084920997  0.0087524727
## ASV1314     -0.0158205967 -0.0165416752 -0.0172911358 -0.0180745082
## ASV0425     -0.0134806848 -0.0137394536 -0.0140002381 -0.0142689770
## ASV0559     -0.0111288767 -0.0115253422 -0.0119361151 -0.0123592169
## ASV0148     -0.0056424428 -0.0056174260 -0.0055831495 -0.0055438136
## ASV0129      0.0020748969  0.0023236797  0.0025840975  0.0028505046
## ASV1072      0.0023797918  0.0023849482  0.0023900116  0.0024065407
## ASV2390      0.0011134936  0.0010717669  0.0010269647  0.0009732733
## ASV0548      0.0167043290  0.0172449163  0.0177980703  0.0183612331
## ASV0168     -0.0192390682 -0.0198039078 -0.0203823084 -0.0209764059
## ASV0066     -0.0131454670 -0.0134228311 -0.0136981458 -0.0139695053
## ASV0468     -0.0073940905 -0.0076893714 -0.0079963381 -0.0083245584
## ASV0172      0.0044971592  0.0047862989  0.0050867575  0.0053971733
## ASV0236      0.0016548405  0.0018692827  0.0020915187  0.0023199302
## ASV0250      0.0147477955  0.0155261285  0.0163353203  0.0171750500
## ASV0338      0.0029869908  0.0031140492  0.0032436985  0.0033794407
## ASV0450     -0.0007103592 -0.0007785114 -0.0008515585 -0.0009247367
## ASV0377      0.0169771037  0.0174126405  0.0178506058  0.0182959890
## ASV1022      0.0068324321  0.0071045137  0.0073862629  0.0076832342
## ASV6174     -0.0011643637 -0.0011846162 -0.0012025720 -0.0012235142
## ASV0786      0.0007326668  0.0007402373  0.0007479002  0.0007608610
## ASV0053     -0.0219042404 -0.0225425999 -0.0231921542 -0.0238501268
## ASV0697     -0.0026063090 -0.0026359254 -0.0026665762 -0.0026936744
## ASV0785      0.0169980439  0.0175726459  0.0181656659  0.0187762729
## ASV1967     -0.0071958587 -0.0073628635 -0.0075318356 -0.0077072645
## ASV0385     -0.0019207600 -0.0019460583 -0.0019717802 -0.0019928002
## ASV0295      0.0080687562  0.0084981848  0.0089440143  0.0094123153
## ASV0072     -0.0087913081 -0.0088619262 -0.0089269172 -0.0089858774
## ASV0157      0.0022421981  0.0025986099  0.0029787203  0.0033876865
## ASV0501      0.0126433627  0.0130959650  0.0135593101  0.0140356568
## ASV10729    -0.0146143622 -0.0150603663 -0.0155148643 -0.0159870213
## ASV1470      0.0036252590  0.0036580967  0.0036874373  0.0037088472
## ASV0050     -0.0370164973 -0.0379704260 -0.0389362498 -0.0399170374
## ASV0411      0.0014468262  0.0014890480  0.0015272002  0.0015647840
## ASV0549      0.0135247505  0.0140534470  0.0145975362  0.0151505247
## ASV0184      0.0064437343  0.0066885451  0.0069409751  0.0072081926
## ASV0705      0.0065554703  0.0067157738  0.0068755067  0.0070394989
## ASV1715      0.0171278561  0.0176816349  0.0182482910  0.0188234240
## ASV0603      0.0047669759  0.0050172737  0.0052787256  0.0055573866
## ASV0826      0.0026979248  0.0027306478  0.0027619516  0.0027976822
## ASV0034     -0.0129279681 -0.0131566537 -0.0133838793 -0.0136054503
## ASV0838      0.0013479283  0.0012773796  0.0011989039  0.0011208847
## ASV0614     -0.0084565194 -0.0086343786 -0.0088118359 -0.0089952508
## ASV0014     -0.0374076883 -0.0384307798 -0.0394707938 -0.0405267156
## ASV0585     -0.0024417867 -0.0024823066 -0.0025212850 -0.0025524049
## ASV0016     -0.0387307174 -0.0398026684 -0.0408930005 -0.0419977131
## ASV5394     -0.0106541531 -0.0108934536 -0.0111285972 -0.0113677113
## ASV0666      0.0078197667  0.0080200972  0.0082232950  0.0084363655
## ASV2085     -0.0025341651 -0.0027145746 -0.0029024867 -0.0031028642
## ASV0003     -0.0343028342 -0.0352411782 -0.0361962271 -0.0371606226
## ASV0346      0.0054363507  0.0056889744  0.0059490396  0.0062226105
## ASV0267     -0.0019773545 -0.0020050054 -0.0020363031 -0.0020661119
## ASV0353      0.0166579153  0.0173196402  0.0179997386  0.0187024109
## ASV2419      0.0090642294  0.0092837703  0.0095041690  0.0097209943
## ASV0447      0.0124009991  0.0128972428  0.0134085366  0.0139388862
## ASV0654      0.0183899824  0.0189136489  0.0194459060  0.0199817106
## ASV0151      0.0099800296  0.0104614295  0.0109608730  0.0114859364
## ASV0065     -0.0132538840 -0.0135739948 -0.0138972878 -0.0142219784
## ASV0527      0.0105176177  0.0107991913  0.0110844128  0.0113719146
## ASV4055     -0.0092655450 -0.0097344889 -0.0102263503 -0.0107507545
## ASV0166     -0.0086306475 -0.0088189364 -0.0090098282 -0.0091988975
## ASV0417     -0.0097099751 -0.0099943988 -0.0102858003 -0.0105793829
## ASV0078     -0.0027301778 -0.0026270529 -0.0025124644 -0.0023834041
## ASV0322     -0.0054032495 -0.0054542545 -0.0055028843 -0.0055530730
## ASV0156     -0.0117975589 -0.0121395488 -0.0124901889 -0.0128440829
## ASV0648     -0.0159518026 -0.0164930019 -0.0170474577 -0.0176217455
## ASV0407      0.0035934329  0.0037628674  0.0039384325  0.0041129081
## ASV2030     -0.0025867069 -0.0027170239 -0.0028539278 -0.0030013731
## ASV0300      0.0127741939  0.0132193381  0.0136727852  0.0141390118
## ASV1150      0.0014944156  0.0015746306  0.0016559269  0.0017320402
## ASV0958      0.0175371510  0.0183469858  0.0191882063  0.0200675555
## ASV0216     -0.0109190426 -0.0112945152 -0.0116843225 -0.0120858562
## ASV0446      0.0260383056  0.0269172023  0.0278152868  0.0287370876
## ASV0367     -0.0062600300 -0.0064564395 -0.0066576215 -0.0068585960
## ASV0200     -0.0131371968 -0.0135666586 -0.0140062571 -0.0144493607
## ASV0334      0.0007383493  0.0008332566  0.0009297190  0.0010246959
## ASV1311      0.0063093770  0.0064337844  0.0065566208  0.0066802006
## ASV0458      0.0090678088  0.0093484779  0.0096354133  0.0099329399
## ASV1371      0.0004507481  0.0004597590  0.0004684545  0.0004710584
## ASV0418      0.0126596266  0.0130998943  0.0135528984  0.0140242016
## ASV0004      0.0123714588  0.0127080721  0.0130490416  0.0133924882
## ASV1943      0.0081294154  0.0083518399  0.0085782366  0.0087966668
## ASV1495     -0.0085329092 -0.0089386621 -0.0093593182 -0.0097898514
## ASV0901     -0.0214395696 -0.0222538416 -0.0230932345 -0.0239524042
## ASV0628      0.0040206826  0.0039746824  0.0039170121  0.0038425481
## ASV0400      0.0010981979  0.0010249756  0.0009423226  0.0008550170
## ASV0116     -0.0183053166 -0.0189970376 -0.0197079914 -0.0204363471
## ASV0788      0.0100233534  0.0103303457  0.0106446634  0.0109720831
## ASV0117      0.0118114921  0.0122992415  0.0128025534  0.0133243994
## ASV3137      0.0017010390  0.0017866468  0.0018783532  0.0019718387
## ASV0001      0.0093853829  0.0095573480  0.0097301806  0.0098977639
## ASV1651      0.0081716977  0.0084376011  0.0087139571  0.0089980994
## ASV1692      0.0173213529  0.0179826838  0.0186650023  0.0193717758
## ASV0660     -0.0008000443 -0.0010190132 -0.0012514428 -0.0014939667
## ASV0508     -0.0004425715 -0.0004881594 -0.0005377480 -0.0005988223
## ASV1660     -0.0069038417 -0.0071177349 -0.0073336792 -0.0075576709
## ASV0233      0.0061027889  0.0063964291  0.0067026536  0.0070237209
## ASV1343     -0.0142142597 -0.0147287941 -0.0152592217 -0.0158092255
## ASV0209      0.0063211086  0.0064501638  0.0065802930  0.0067083494
## ASV0193     -0.0104453640 -0.0107206504 -0.0110010594 -0.0112899172
## ASV0357      0.0063871427  0.0067881354  0.0072086790  0.0076534663
## ASV0198      0.0045755399  0.0047708909  0.0049730666  0.0051857837
## ASV0007      0.0089286990  0.0090931276  0.0092584085  0.0094180842
## ASV1772      0.0014328955  0.0016380016  0.0018604719  0.0021047505
## ASV0009      0.0081371914  0.0082830761  0.0084298877  0.0085711664
## ASV0006     -0.0005142307 -0.0006200615 -0.0007294285 -0.0008493746
## ASV0011     -0.0202215052 -0.0209165385 -0.0216284394 -0.0223540686
## ASV0015      0.0100186460  0.0102615214  0.0105048613  0.0107491038
## ASV0017      0.0107235433  0.0109972643  0.0112728268  0.0115498961
## ASV0235     -0.0110127643 -0.0113921045 -0.0117830072 -0.0121881336
## ASV0382      0.0047822588  0.0048675533  0.0049458414  0.0050202152
## ASV2357      0.0173534146  0.0179641279  0.0185903339  0.0192286384
## ASV0567     -0.0109878361 -0.0113949034 -0.0118152502 -0.0122519551
## ASV0165      0.0113877255  0.0117450885  0.0121117152  0.0124885348
## ASV0005      0.0167309055  0.0170787520  0.0174266392  0.0177677734
## ASV0384      0.0060914264  0.0065112751  0.0069538782  0.0074224921
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## ASV3017      0.0097304469  0.0099719129  0.0102171543  0.0104651501
## ASV0091      0.0063922122  0.0065698814  0.0067472368  0.0069264118
## ASV0186     -0.0136779144 -0.0140246242 -0.0143726617 -0.0147187159
## ASV0370      0.0035585688  0.0037441902  0.0039382303  0.0041402929
## ASV0018      0.0186399516  0.0190729406  0.0195092597  0.0199425546
## ASV1377      0.0171488530  0.0176073272  0.0180738465  0.0185471725
## ASV0019      0.0189268468  0.0193776614  0.0198327662  0.0202861456
## ASV0023     -0.0041107199 -0.0043046095 -0.0045026400 -0.0047099560
## ASV2194      0.0114591947  0.0118926757  0.0123384230  0.0127943915
## ASV1155      0.0024079750  0.0025359598  0.0026684895  0.0028066740
## ASV0510     -0.0024902430 -0.0024903579 -0.0024892607 -0.0024830294
## ASV2371     -0.0046919560 -0.0047706554 -0.0048489937 -0.0049277559
## ASV0024     -0.0053642634 -0.0056009206 -0.0058430254 -0.0060944178
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## ASV11516    -0.0045011002 -0.0045930630 -0.0046861718 -0.0047829299
## ASV14377    -0.0045013708 -0.0045933701 -0.0046865187 -0.0047827735
## ASV1867      0.0149307504  0.0154505773  0.0159853576  0.0165339514
## ASV1895     -0.0020305363 -0.0021076744 -0.0021879142 -0.0022709761
## ASV3168      0.0024399682  0.0024588413  0.0024764754  0.0024911839
## ASV4449      0.0081996506  0.0084533497  0.0087144595  0.0089845776
## ASV6596      0.0129269927  0.0134750998  0.0140407104  0.0146241675
## ASV7492      0.0019753157  0.0021031104  0.0022345893  0.0023691636
## ASV9854     -0.0018056015 -0.0018318746 -0.0018582246 -0.0018859583
## ASV6296      0.0045027606  0.0045949313  0.0046882670  0.0047824895
## ASV4201      0.0106508426  0.0111437032  0.0116546712  0.0121853554
## ASV0552      0.0242173233  0.0249448851  0.0256820274  0.0264309051
## ASV3671      0.0006775280  0.0006925963  0.0007057823  0.0007178559
## ASV3529      0.0019003776  0.0019771893  0.0020543839  0.0021329347
## ASV1060      0.0093844640  0.0098290259  0.0102933723  0.0107817115
## ASV0239     -0.0049712870 -0.0050022770 -0.0050293744 -0.0050490727
## ASV5711     -0.0075975017 -0.0077901946 -0.0079859068 -0.0081827667
## ASV4152     -0.0121289362 -0.0124510829 -0.0127775218 -0.0131076079
## ASV1461      0.0068326231  0.0069612882  0.0070909338  0.0072190777
## ASV2877      0.0073527546  0.0074867045  0.0076184968  0.0077487518
## ASV0012      0.0121672223  0.0126131765  0.0130701275  0.0135359319
## ASV9823      0.0002937117  0.0002735516  0.0002533958  0.0002307021
## ASV0008      0.0126725241  0.0131361542  0.0136114587  0.0140946154
## ASV7832     -0.0074171606 -0.0076327871 -0.0078527899 -0.0080754029
## ASV1915      0.0014050119  0.0014198975  0.0014326863  0.0014435744
## ASV0055      0.0043583984  0.0044027907  0.0044408606  0.0044679942
## ASV0032      0.0111412357  0.0114703150  0.0118101186  0.0121593371
## ASV2977     -0.0099000144 -0.0101512648 -0.0104052940 -0.0106613657
## ASV0466      0.0068384264  0.0069378316  0.0070348995  0.0071277411
## ASV3866      0.0166887302  0.0173443858  0.0180238484  0.0187287095
## ASV0040      0.0225619371  0.0233410176  0.0241383254  0.0249487798
## ASV0496     -0.0065349587 -0.0068337403 -0.0071417404 -0.0074631726
## ASV0052      0.0169239463  0.0173503872  0.0177823902  0.0182187812
## ASV3828     -0.0125254019 -0.0129702508 -0.0134302882 -0.0139027919
## ASV1930      0.0065986756  0.0067548302  0.0069124283  0.0070708556
## ASV2126      0.0114429261  0.0117530447  0.0120678007  0.0123877133
## ASV0793      0.0136058147  0.0141323106  0.0146753491  0.0152335469
## ASV0299     -0.0028311489 -0.0029623520 -0.0031024068 -0.0032522861
## ASV0208      0.0193468719  0.0201305587  0.0209404227  0.0217787643
## ASV0511     -0.0003283369 -0.0002729676 -0.0002165202 -0.0001627217
## ASV1123     -0.0035668963 -0.0035803609 -0.0035895086 -0.0035951829
## ASV0099      0.0003535551  0.0005523025  0.0007662248  0.0009931809
## ASV0752     -0.0027583337 -0.0028665319 -0.0029779261 -0.0030942073
## ASV0883      0.0014050276  0.0014648969  0.0015266101  0.0015913819
## ASV0683      0.0150481951  0.0155723522  0.0161077715  0.0166548502
## ASV4117     -0.0120538267 -0.0124347276 -0.0128249556 -0.0132209103
## ASV2172      0.0054295311  0.0056178454  0.0058116329  0.0060120855
## ASV0330     -0.0095292027 -0.0098497992 -0.0101800992 -0.0105193727
## ASV0728      0.0112502962  0.0116534328  0.0120686710  0.0124969014
## ASV0499      0.0248123183  0.0257609512  0.0267363735  0.0277371289
## ASV0120     -0.0156422242 -0.0160232405 -0.0164065196 -0.0167934102
## ASV1446     -0.0039267174 -0.0042059643 -0.0045005325 -0.0048130962
## ASV17171    -0.0124517540 -0.0128745046 -0.0133086263 -0.0137510815
## ASV0533      0.0061233971  0.0063624065  0.0066074950  0.0068635517
## ASV2495     -0.0083742666 -0.0087065485 -0.0090479621 -0.0093958183
## ASV5582      0.0008131241  0.0007725926  0.0007279523  0.0006799014
## ASV1488      0.0050890903  0.0052411822  0.0053952518  0.0055526251
## ASV0682      0.0162912848  0.0168726301  0.0174675584  0.0180799923
## ASV0068     -0.0034068699 -0.0035030222 -0.0035981917 -0.0036917491
## ASV1987     -0.0122629209 -0.0127777333 -0.0133096403 -0.0138609165
## ASV0035     -0.0095404739 -0.0101704542 -0.0108314020 -0.0115245538
## ASV7192     -0.0039687026 -0.0040022581 -0.0040332507 -0.0040590090
## ASV0873     -0.0008491998 -0.0008781128 -0.0009062293 -0.0009350239
## ASV4749     -0.0069731204 -0.0073444107 -0.0077298438 -0.0081323367
## ASV2174      0.0049466332  0.0051241531  0.0053104698  0.0055041754
## ASV1476     -0.0088747523 -0.0091973582 -0.0095286962 -0.0098656217
## ASV0740     -0.0229455469 -0.0237759982 -0.0246286566 -0.0255040825
## ASV0170      0.0041545609  0.0043085879  0.0044679410  0.0046335969
## ASV2466     -0.0172289592 -0.0178477265 -0.0184843525 -0.0191359270
## ASV1709      0.0101512371  0.0104279738  0.0107091675  0.0109912964
## ASV6170     -0.0124874564 -0.0128931691 -0.0133077157 -0.0137313213
## ASV3673      0.0146261511  0.0151093502  0.0156034305  0.0161085058
## ASV1745      0.0007682484  0.0007706842  0.0007714023  0.0007698066

stats::glm for first 500

library(stats)

logreg_500 <- stats::glm(as.factor(Clade) ~ . ,
                          data = lr_clr_df_500[,-1],
                          family = "binomial")
summary(logreg_500)
## 
## Call:
## stats::glm(formula = as.factor(Clade) ~ ., family = "binomial", 
##     data = lr_clr_df_500[, -1])
## 
## Coefficients: (265 not defined because of singularities)
##               Estimate Std. Error    z value Pr(>|z|)    
## (Intercept) -6.182e+14  4.777e+06 -129409473   <2e-16 ***
## ASV1236      2.123e+29  4.696e+21   45216417   <2e-16 ***
## ASV0421     -3.339e+27  1.465e+21   -2280171   <2e-16 ***
## ASV0691     -2.347e+29  1.391e+22  -16876329   <2e-16 ***
## ASV0899      8.814e+26  2.199e+21     400795   <2e-16 ***
## ASV1004     -2.385e+28  1.745e+21  -13664670   <2e-16 ***
## ASV1041      5.366e+28  2.882e+21   18619833   <2e-16 ***
## ASV1058      8.977e+27  3.905e+21    2298709   <2e-16 ***
## ASV12542    -1.419e+29  7.419e+21  -19121612   <2e-16 ***
## ASV1294      9.893e+28  3.717e+21   26612263   <2e-16 ***
## ASV13113     3.794e+26  2.713e+19   13987056   <2e-16 ***
## ASV1318      1.344e+28  6.788e+20   19804118   <2e-16 ***
## ASV2269      9.142e+29  1.136e+22   80453672   <2e-16 ***
## ASV2542     -1.046e+28  7.226e+20  -14478056   <2e-16 ***
## ASV2660     -4.561e+29  1.113e+22  -40975358   <2e-16 ***
## ASV2737     -5.419e+29  9.446e+21  -57372848   <2e-16 ***
## ASV2840      2.317e+28  1.073e+21   21589550   <2e-16 ***
## ASV3053     -2.367e+29  2.192e+22  -10801335   <2e-16 ***
## ASV3077      1.930e+29  2.405e+22    8025864   <2e-16 ***
## ASV3134      2.427e+27  1.338e+20   18140960   <2e-16 ***
## ASV3140      4.185e+28  6.432e+21    6506480   <2e-16 ***
## ASV3579      1.886e+27  2.159e+20    8737685   <2e-16 ***
## ASV6119             NA         NA         NA       NA    
## ASV7557             NA         NA         NA       NA    
## ASV8422             NA         NA         NA       NA    
## ASV1086             NA         NA         NA       NA    
## ASV1310      2.970e+28  1.276e+21   23272941   <2e-16 ***
## ASV15750    -2.470e+28  1.258e+22   -1963319   <2e-16 ***
## ASV16905            NA         NA         NA       NA    
## ASV2033     -4.788e+28  1.496e+21  -32006083   <2e-16 ***
## ASV2089             NA         NA         NA       NA    
## ASV2127      3.534e+28  9.440e+20   37438803   <2e-16 ***
## ASV2725      6.988e+28  5.268e+21   13265769   <2e-16 ***
## ASV2804             NA         NA         NA       NA    
## ASV3075     -5.219e+27  2.910e+20  -17937520   <2e-16 ***
## ASV3327     -1.048e+28  1.772e+21   -5913674   <2e-16 ***
## ASV3342     -3.801e+27  3.094e+20  -12286151   <2e-16 ***
## ASV3532     -4.181e+28  1.109e+21  -37707994   <2e-16 ***
## ASV3600     -1.582e+28  1.494e+21  -10590680   <2e-16 ***
## ASV4013     -1.305e+28  2.993e+21   -4360053   <2e-16 ***
## ASV4136     -5.014e+28  5.014e+21   -9998502   <2e-16 ***
## ASV4195             NA         NA         NA       NA    
## ASV4407             NA         NA         NA       NA    
## ASV4717             NA         NA         NA       NA    
## ASV6794             NA         NA         NA       NA    
## ASV8324             NA         NA         NA       NA    
## ASV8981     -4.721e+27  2.100e+21   -2247818   <2e-16 ***
## ASV9859      5.319e+28  1.443e+21   36871347   <2e-16 ***
## ASV0936     -2.145e+28  1.320e+21  -16249863   <2e-16 ***
## ASV12683            NA         NA         NA       NA    
## ASV1293      6.975e+28  2.252e+21   30969406   <2e-16 ***
## ASV13055            NA         NA         NA       NA    
## ASV17063            NA         NA         NA       NA    
## ASV2228             NA         NA         NA       NA    
## ASV2769      9.752e+28  5.801e+21   16810001   <2e-16 ***
## ASV2803     -4.597e+28  7.594e+21   -6053405   <2e-16 ***
## ASV2896     -5.741e+27  3.505e+20  -16379422   <2e-16 ***
## ASV3062             NA         NA         NA       NA    
## ASV3107      1.231e+27  4.917e+19   25035169   <2e-16 ***
## ASV3265      6.707e+28  3.244e+21   20674218   <2e-16 ***
## ASV3666             NA         NA         NA       NA    
## ASV4497      2.618e+29  9.038e+21   28962509   <2e-16 ***
## ASV6914             NA         NA         NA       NA    
## ASV0576      3.029e+29  8.855e+21   34202592   <2e-16 ***
## ASV0673     -5.720e+28  4.058e+21  -14096182   <2e-16 ***
## ASV0772     -1.056e+29  4.102e+21  -25731324   <2e-16 ***
## ASV0862             NA         NA         NA       NA    
## ASV0898             NA         NA         NA       NA    
## ASV0910      2.278e+27  6.738e+20    3381392   <2e-16 ***
## ASV0964             NA         NA         NA       NA    
## ASV10059    -5.227e+27  3.173e+20  -16472013   <2e-16 ***
## ASV10263            NA         NA         NA       NA    
## ASV1088     -7.048e+28  4.070e+21  -17314266   <2e-16 ***
## ASV1101             NA         NA         NA       NA    
## ASV1183      3.239e+28  7.980e+20   40588813   <2e-16 ***
## ASV11956            NA         NA         NA       NA    
## ASV12774            NA         NA         NA       NA    
## ASV1321             NA         NA         NA       NA    
## ASV13793            NA         NA         NA       NA    
## ASV14482            NA         NA         NA       NA    
## ASV15483            NA         NA         NA       NA    
## ASV2062             NA         NA         NA       NA    
## ASV2132     -2.823e+26  3.752e+20    -752486   <2e-16 ***
## ASV2413             NA         NA         NA       NA    
## ASV2490             NA         NA         NA       NA    
## ASV2594      3.183e+28  1.499e+21   21231791   <2e-16 ***
## ASV2822             NA         NA         NA       NA    
## ASV2863             NA         NA         NA       NA    
## ASV2910             NA         NA         NA       NA    
## ASV2980     -2.171e+29  1.041e+22  -20863040   <2e-16 ***
## ASV3307             NA         NA         NA       NA    
## ASV3474             NA         NA         NA       NA    
## ASV3502     -8.739e+28  2.316e+21  -37733169   <2e-16 ***
## ASV4236             NA         NA         NA       NA    
## ASV4842             NA         NA         NA       NA    
## ASV4894             NA         NA         NA       NA    
## ASV5290             NA         NA         NA       NA    
## ASV5501     -2.010e+29  9.903e+21  -20297043   <2e-16 ***
## ASV5795             NA         NA         NA       NA    
## ASV5987             NA         NA         NA       NA    
## ASV6267             NA         NA         NA       NA    
## ASV6862             NA         NA         NA       NA    
## ASV7145             NA         NA         NA       NA    
## ASV7673             NA         NA         NA       NA    
## ASV7789             NA         NA         NA       NA    
## ASV7809             NA         NA         NA       NA    
## ASV8002             NA         NA         NA       NA    
## ASV8205      1.775e+28  4.555e+20   38970818   <2e-16 ***
## ASV9155             NA         NA         NA       NA    
## ASV9221     -6.316e+28  1.748e+21  -36135509   <2e-16 ***
## ASV9311             NA         NA         NA       NA    
## ASV9557             NA         NA         NA       NA    
## ASV9936             NA         NA         NA       NA    
## ASV1445      3.810e+28  2.728e+21   13968030   <2e-16 ***
## ASV4232      3.112e+27  8.922e+19   34879002   <2e-16 ***
## ASV6479      1.468e+28  2.648e+20   55445127   <2e-16 ***
## ASV0142      7.254e+28  1.657e+22    4377911   <2e-16 ***
## ASV0378      5.466e+28  3.315e+21   16488059   <2e-16 ***
## ASV1122      3.969e+27  1.070e+21    3709293   <2e-16 ***
## ASV0123      4.459e+28  1.852e+22    2407393   <2e-16 ***
## ASV2064      2.092e+28  2.770e+21    7551052   <2e-16 ***
## ASV4459      4.558e+27  1.360e+21    3350420   <2e-16 ***
## ASV0448      2.299e+27  2.737e+20    8397314   <2e-16 ***
## ASV0397      2.408e+28  5.702e+20   42222914   <2e-16 ***
## ASV0485      2.246e+28  5.415e+20   41480237   <2e-16 ***
## ASV1566             NA         NA         NA       NA    
## ASV1365      5.600e+28  2.396e+21   23375779   <2e-16 ***
## ASV1065     -5.723e+28  2.710e+21  -21114691   <2e-16 ***
## ASV0722     -1.356e+28  1.172e+21  -11575594   <2e-16 ***
## ASV12660            NA         NA         NA       NA    
## ASV0223      1.167e+28  4.523e+20   25807199   <2e-16 ***
## ASV0229      8.896e+28  4.466e+21   19920205   <2e-16 ***
## ASV0877      4.314e+28  2.378e+21   18143859   <2e-16 ***
## ASV0983     -6.317e+28  2.285e+21  -27639533   <2e-16 ***
## ASV0626             NA         NA         NA       NA    
## ASV4146      6.781e+28  2.325e+21   29160987   <2e-16 ***
## ASV4175      2.575e+28  2.686e+21    9585611   <2e-16 ***
## ASV2082     -1.657e+29  2.670e+21  -62046598   <2e-16 ***
## ASV2272      1.038e+26  3.277e+20     316856   <2e-16 ***
## ASV2245      4.766e+28  2.042e+21   23340051   <2e-16 ***
## ASV0590             NA         NA         NA       NA    
## ASV0217      1.112e+28  7.966e+20   13958071   <2e-16 ***
## ASV0416     -7.986e+28  2.447e+21  -32640530   <2e-16 ***
## ASV1056     -1.781e+28  6.316e+20  -28192893   <2e-16 ***
## ASV7777     -2.463e+26  1.156e+19  -21300500   <2e-16 ***
## ASV0455      1.516e+28  7.165e+20   21158808   <2e-16 ***
## ASV0604             NA         NA         NA       NA    
## ASV6100     -9.919e+26  8.304e+19  -11945509   <2e-16 ***
## ASV11359    -1.265e+29  2.380e+21  -53159591   <2e-16 ***
## ASV6604     -5.807e+27  5.052e+20  -11493083   <2e-16 ***
## ASV5004      2.426e+28  1.352e+21   17939400   <2e-16 ***
## ASV1483      6.172e+28  3.116e+21   19804183   <2e-16 ***
## ASV9773      4.850e+25  4.268e+18   11362839   <2e-16 ***
## ASV4059      9.084e+27  3.578e+20   25387453   <2e-16 ***
## ASV1193      7.629e+27  2.837e+20   26886572   <2e-16 ***
## ASV4610             NA         NA         NA       NA    
## ASV0742             NA         NA         NA       NA    
## ASV1502     -1.837e+28  9.116e+20  -20152035   <2e-16 ***
## ASV0195     -2.859e+28  1.033e+21  -27665002   <2e-16 ***
## ASV1213      4.522e+28  9.431e+20   47949493   <2e-16 ***
## ASV1648      9.589e+27  5.457e+20   17570811   <2e-16 ***
## ASV6984      3.940e+27  2.007e+20   19631396   <2e-16 ***
## ASV0396     -1.719e+27  6.107e+20   -2814158   <2e-16 ***
## ASV4297             NA         NA         NA       NA    
## ASV2622      1.366e+28  8.335e+20   16393754   <2e-16 ***
## ASV3512     -5.475e+27  2.312e+20  -23676426   <2e-16 ***
## ASV2411             NA         NA         NA       NA    
## ASV2291             NA         NA         NA       NA    
## ASV0807     -3.063e+28  1.074e+21  -28510734   <2e-16 ***
## ASV1292     -1.912e+28  7.504e+20  -25480131   <2e-16 ***
## ASV1035             NA         NA         NA       NA    
## ASV0070     -6.381e+27  1.856e+20  -34377281   <2e-16 ***
## ASV0255      1.184e+28  3.753e+20   31542113   <2e-16 ***
## ASV0057      8.422e+27  2.387e+20   35278605   <2e-16 ***
## ASV0077     -1.780e+26  8.104e+19   -2195845   <2e-16 ***
## ASV0625      2.904e+28  7.410e+20   39186019   <2e-16 ***
## ASV2464             NA         NA         NA       NA    
## ASV1315     -1.790e+28  3.860e+20  -46372336   <2e-16 ***
## ASV2673      2.981e+27  1.837e+20   16224210   <2e-16 ***
## ASV2161      1.281e+28  2.781e+20   46065233   <2e-16 ***
## ASV0337     -1.000e+28  3.250e+20  -30777275   <2e-16 ***
## ASV7680     -1.920e+28  5.831e+20  -32923423   <2e-16 ***
## ASV0611      2.757e+27  5.656e+19   48735739   <2e-16 ***
## ASV3118      2.529e+28  1.253e+21   20181562   <2e-16 ***
## ASV1284      2.438e+27  4.725e+19   51590914   <2e-16 ***
## ASV0889             NA         NA         NA       NA    
## ASV4649     -1.995e+28  5.542e+20  -35992760   <2e-16 ***
## ASV1108     -9.317e+27  4.737e+20  -19666502   <2e-16 ***
## ASV0738     -1.579e+27  1.359e+20  -11620248   <2e-16 ***
## ASV0473      2.657e+26  5.867e+19    4527986   <2e-16 ***
## ASV0598             NA         NA         NA       NA    
## ASV0429     -7.983e+27  2.842e+20  -28083682   <2e-16 ***
## ASV1549     -2.087e+27  1.391e+20  -15003354   <2e-16 ***
## ASV1203      1.752e+28  4.371e+20   40078834   <2e-16 ***
## ASV4532     -4.181e+27  2.054e+20  -20359926   <2e-16 ***
## ASV0274      6.795e+27  6.302e+20   10782272   <2e-16 ***
## ASV0163     -1.173e+29  1.865e+21  -62904056   <2e-16 ***
## ASV1298      1.471e+28  3.990e+20   36868532   <2e-16 ***
## ASV9424      1.698e+28  4.790e+20   35445490   <2e-16 ***
## ASV0412     -8.239e+28  2.309e+21  -35680912   <2e-16 ***
## ASV0284      9.333e+27  4.238e+20   22021741   <2e-16 ***
## ASV0620             NA         NA         NA       NA    
## ASV0153     -1.249e+28  5.891e+20  -21195628   <2e-16 ***
## ASV0498     -8.692e+27  2.742e+20  -31695746   <2e-16 ***
## ASV0097     -6.180e+26  1.361e+20   -4539713   <2e-16 ***
## ASV0104     -1.141e+28  7.642e+20  -14930886   <2e-16 ***
## ASV1282     -2.869e+28  5.517e+20  -51997642   <2e-16 ***
## ASV3883      1.762e+28  5.415e+20   32545169   <2e-16 ***
## ASV0801     -8.597e+26  5.250e+20   -1637581   <2e-16 ***
## ASV1611     -2.056e+28  1.387e+21  -14823385   <2e-16 ***
## ASV0227      9.413e+27  3.081e+20   30552649   <2e-16 ***
## ASV0833             NA         NA         NA       NA    
## ASV0718     -4.782e+27  1.351e+20  -35405833   <2e-16 ***
## ASV1139             NA         NA         NA       NA    
## ASV0766     -8.412e+28  1.588e+21  -52986205   <2e-16 ***
## ASV2091      4.070e+28  5.984e+20   68007345   <2e-16 ***
## ASV1238      5.987e+28  1.132e+21   52891153   <2e-16 ***
## ASV9193             NA         NA         NA       NA    
## ASV0290      2.088e+28  7.344e+20   28425738   <2e-16 ***
## ASV0231      4.935e+27  9.224e+20    5349771   <2e-16 ***
## ASV0185     -7.025e+27  1.948e+20  -36054822   <2e-16 ***
## ASV2330             NA         NA         NA       NA    
## ASV3119      1.446e+26  1.068e+20    1354947   <2e-16 ***
## ASV2368      7.412e+27  3.163e+20   23435518   <2e-16 ***
## ASV0122      1.671e+27  1.164e+20   14359307   <2e-16 ***
## ASV1044      9.303e+27  3.893e+20   23898118   <2e-16 ***
## ASV0160     -1.088e+27  2.979e+20   -3651142   <2e-16 ***
## ASV0326      6.557e+26  4.740e+19   13835205   <2e-16 ***
## ASV1388      3.792e+26  1.103e+20    3438757   <2e-16 ***
## ASV0792             NA         NA         NA       NA    
## ASV0036      5.475e+28  1.409e+21   38858895   <2e-16 ***
## ASV2125     -9.065e+27  2.113e+20  -42906066   <2e-16 ***
## ASV1075      8.252e+26  5.722e+19   14420126   <2e-16 ***
## ASV0390      2.048e+27  6.864e+19   29835524   <2e-16 ***
## ASV3790      4.586e+27  2.213e+20   20717092   <2e-16 ***
## ASV1535      1.072e+28  6.519e+20   16451373   <2e-16 ***
## ASV0263             NA         NA         NA       NA    
## ASV0675     -2.488e+27  1.619e+20  -15367213   <2e-16 ***
## ASV3348     -2.007e+27  1.369e+20  -14660204   <2e-16 ***
## ASV0058     -2.883e+27  2.239e+20  -12873935   <2e-16 ***
## ASV4142             NA         NA         NA       NA    
## ASV0059     -1.589e+27  1.796e+20   -8846787   <2e-16 ***
## ASV0013      6.233e+27  2.914e+20   21391125   <2e-16 ***
## ASV0033     -5.537e+28  1.476e+21  -37506130   <2e-16 ***
## ASV4354             NA         NA         NA       NA    
## ASV0022      9.054e+27  5.160e+20   17545537   <2e-16 ***
## ASV0134     -7.203e+27  4.395e+20  -16387881   <2e-16 ***
## ASV0415     -1.414e+27  2.586e+20   -5468209   <2e-16 ***
## ASV10103            NA         NA         NA       NA    
## ASV1613      6.070e+27  1.581e+20   38403785   <2e-16 ***
## ASV0135      1.278e+27  6.775e+19   18869774   <2e-16 ***
## ASV0469             NA         NA         NA       NA    
## ASV0471     -3.420e+27  1.325e+20  -25813410   <2e-16 ***
## ASV0451      5.926e+26  3.528e+19   16798633   <2e-16 ***
## ASV0747     -7.054e+27  3.942e+20  -17892099   <2e-16 ***
## ASV1314      1.556e+26  8.248e+18   18869774   <2e-16 ***
## ASV0425             NA         NA         NA       NA    
## ASV0559      4.513e+27  9.349e+20    4826634   <2e-16 ***
## ASV0148     -4.526e+26  5.525e+19   -8192110   <2e-16 ***
## ASV0129     -2.615e+27  1.981e+20  -13201123   <2e-16 ***
## ASV1072     -1.449e+27  5.203e+19  -27856569   <2e-16 ***
## ASV2390             NA         NA         NA       NA    
## ASV0548      2.377e+27  9.340e+19   25450189   <2e-16 ***
## ASV0168     -2.959e+25  4.998e+18   -5920634   <2e-16 ***
## ASV0066      2.673e+25  3.366e+18    7940261   <2e-16 ***
## ASV0468     -7.060e+25  8.892e+18   -7940164   <2e-16 ***
## ASV0172      6.399e+27  2.033e+20   31474220   <2e-16 ***
## ASV0236     -5.418e+26  3.289e+20   -1647216   <2e-16 ***
## ASV0250     -4.886e+26  2.519e+19  -19396720   <2e-16 ***
## ASV0338     -3.011e+28  5.094e+20  -59112710   <2e-16 ***
## ASV0450     -1.248e+27  8.890e+19  -14034775   <2e-16 ***
## ASV0377             NA         NA         NA       NA    
## ASV1022     -3.247e+25  4.324e+18   -7508997   <2e-16 ***
## ASV6174             NA         NA         NA       NA    
## ASV0786             NA         NA         NA       NA    
## ASV0053     -1.927e+27  1.147e+20  -16798122   <2e-16 ***
## ASV0697      2.929e+26  2.437e+19   12018764   <2e-16 ***
## ASV0785      8.594e+26  3.969e+19   21653812   <2e-16 ***
## ASV1967      4.298e+26  3.208e+19   13398521   <2e-16 ***
## ASV0385     -6.202e+27  2.706e+20  -22921349   <2e-16 ***
## ASV0295      4.224e+25  5.618e+18    7517355   <2e-16 ***
## ASV0072      3.652e+25  1.285e+19    2842445   <2e-16 ***
## ASV0157      3.202e+27  9.898e+19   32348521   <2e-16 ***
## ASV0501     -3.149e+27  2.557e+20  -12313191   <2e-16 ***
## ASV10729    -6.200e+27  2.775e+20  -22343952   <2e-16 ***
## ASV1470             NA         NA         NA       NA    
## ASV0050      9.006e+27  9.169e+20    9822037   <2e-16 ***
## ASV0411     -2.283e+27  6.093e+19  -37475272   <2e-16 ***
## ASV0549      1.145e+27  2.141e+20    5347599   <2e-16 ***
## ASV0184     -1.297e+23  6.876e+15  -18869774   <2e-16 ***
## ASV0705     -6.517e+26  2.037e+19  -31995727   <2e-16 ***
## ASV1715      7.468e+27  3.808e+20   19609602   <2e-16 ***
## ASV0603     -4.350e+27  2.147e+20  -20259946   <2e-16 ***
## ASV0826             NA         NA         NA       NA    
## ASV0034     -3.742e+26  1.983e+19  -18869774   <2e-16 ***
## ASV0838     -1.531e+27  4.533e+19  -33776806   <2e-16 ***
## ASV0614     -3.183e+27  1.030e+20  -30898797   <2e-16 ***
## ASV0014      2.968e+28  8.689e+20   34161875   <2e-16 ***
## ASV0585             NA         NA         NA       NA    
## ASV0016     -4.066e+28  1.270e+21  -32002485   <2e-16 ***
## ASV5394      3.023e+27  7.408e+19   40810540   <2e-16 ***
## ASV0666             NA         NA         NA       NA    
## ASV2085             NA         NA         NA       NA    
## ASV0003      1.428e+28  1.028e+21   13899977   <2e-16 ***
## ASV0346      8.154e+27  1.422e+20   57340082   <2e-16 ***
## ASV0267     -6.634e+27  2.383e+20  -27837174   <2e-16 ***
## ASV0353      3.572e+27  2.568e+20   13909937   <2e-16 ***
## ASV2419      3.409e+27  1.263e+20   27001947   <2e-16 ***
## ASV0447             NA         NA         NA       NA    
## ASV0654             NA         NA         NA       NA    
## ASV0151     -1.549e+28  6.173e+20  -25101285   <2e-16 ***
## ASV0065     -1.081e+27  8.269e+19  -13071306   <2e-16 ***
## ASV0527      4.818e+27  2.354e+20   20466080   <2e-16 ***
## ASV4055             NA         NA         NA       NA    
## ASV0166             NA         NA         NA       NA    
## ASV0417     -1.481e+27  9.033e+19  -16397284   <2e-16 ***
## ASV0078     -1.887e+26  2.375e+19   -7945398   <2e-16 ***
## ASV0322             NA         NA         NA       NA    
## ASV0156      2.146e+27  8.488e+19   25276689   <2e-16 ***
## ASV0648             NA         NA         NA       NA    
## ASV0407      4.811e+25  2.550e+18   18869774   <2e-16 ***
## ASV2030             NA         NA         NA       NA    
## ASV0300      4.085e+27  1.235e+20   33074872   <2e-16 ***
## ASV1150      6.105e+27  2.181e+20   27991061   <2e-16 ***
## ASV0958     -2.792e+27  9.127e+19  -30590291   <2e-16 ***
## ASV0216             NA         NA         NA       NA    
## ASV0446     -6.499e+27  2.617e+20  -24838950   <2e-16 ***
## ASV0367             NA         NA         NA       NA    
## ASV0200             NA         NA         NA       NA    
## ASV0334             NA         NA         NA       NA    
## ASV1311             NA         NA         NA       NA    
## ASV0458             NA         NA         NA       NA    
## ASV1371             NA         NA         NA       NA    
## ASV0418             NA         NA         NA       NA    
## ASV0004     -4.320e+26  5.432e+19   -7951729   <2e-16 ***
## ASV1943             NA         NA         NA       NA    
## ASV1495     -1.750e+26  4.299e+18  -40697974   <2e-16 ***
## ASV0901             NA         NA         NA       NA    
## ASV0628             NA         NA         NA       NA    
## ASV0400             NA         NA         NA       NA    
## ASV0116             NA         NA         NA       NA    
## ASV0788      2.380e+27  1.088e+20   21867338   <2e-16 ***
## ASV0117     -7.036e+25  8.852e+18   -7948881   <2e-16 ***
## ASV3137             NA         NA         NA       NA    
## ASV0001             NA         NA         NA       NA    
## ASV1651      2.378e+27  1.143e+20   20799911   <2e-16 ***
## ASV1692             NA         NA         NA       NA    
## ASV0660             NA         NA         NA       NA    
## ASV0508             NA         NA         NA       NA    
## ASV1660             NA         NA         NA       NA    
## ASV0233             NA         NA         NA       NA    
## ASV1343             NA         NA         NA       NA    
## ASV0209             NA         NA         NA       NA    
## ASV0193             NA         NA         NA       NA    
## ASV0357      9.213e+27  3.578e+20   25753179   <2e-16 ***
## ASV0198             NA         NA         NA       NA    
## ASV0007             NA         NA         NA       NA    
## ASV1772             NA         NA         NA       NA    
## ASV0009             NA         NA         NA       NA    
## ASV0006             NA         NA         NA       NA    
## ASV0011             NA         NA         NA       NA    
## ASV0015             NA         NA         NA       NA    
## ASV0017             NA         NA         NA       NA    
## ASV0235             NA         NA         NA       NA    
## ASV0382     -8.099e+27  3.496e+20  -23164630   <2e-16 ***
## ASV2357             NA         NA         NA       NA    
## ASV0567             NA         NA         NA       NA    
## ASV0165             NA         NA         NA       NA    
## ASV0005             NA         NA         NA       NA    
## ASV0384             NA         NA         NA       NA    
## ASV0002             NA         NA         NA       NA    
## ASV3017             NA         NA         NA       NA    
## ASV0091             NA         NA         NA       NA    
## ASV0186             NA         NA         NA       NA    
## ASV0370             NA         NA         NA       NA    
## ASV0018             NA         NA         NA       NA    
## ASV1377             NA         NA         NA       NA    
## ASV0019             NA         NA         NA       NA    
## ASV0023             NA         NA         NA       NA    
## ASV2194             NA         NA         NA       NA    
## ASV1155             NA         NA         NA       NA    
## ASV0510             NA         NA         NA       NA    
## ASV2371             NA         NA         NA       NA    
## ASV0024             NA         NA         NA       NA    
## ASV2452             NA         NA         NA       NA    
## ASV2332             NA         NA         NA       NA    
## ASV2591             NA         NA         NA       NA    
## ASV0521             NA         NA         NA       NA    
## ASV5542             NA         NA         NA       NA    
## ASV0336             NA         NA         NA       NA    
## ASV10102            NA         NA         NA       NA    
## ASV16823            NA         NA         NA       NA    
## ASV3104             NA         NA         NA       NA    
## ASV0781             NA         NA         NA       NA    
## ASV10899            NA         NA         NA       NA    
## ASV11222            NA         NA         NA       NA    
## ASV11327            NA         NA         NA       NA    
## ASV12458            NA         NA         NA       NA    
## ASV1636             NA         NA         NA       NA    
## ASV1890             NA         NA         NA       NA    
## ASV2898             NA         NA         NA       NA    
## ASV8328             NA         NA         NA       NA    
## ASV0709             NA         NA         NA       NA    
## ASV0856             NA         NA         NA       NA    
## ASV0909             NA         NA         NA       NA    
## ASV0937             NA         NA         NA       NA    
## ASV11390            NA         NA         NA       NA    
## ASV11966            NA         NA         NA       NA    
## ASV12990            NA         NA         NA       NA    
## ASV14797            NA         NA         NA       NA    
## ASV14904            NA         NA         NA       NA    
## ASV15304            NA         NA         NA       NA    
## ASV16696            NA         NA         NA       NA    
## ASV1690             NA         NA         NA       NA    
## ASV2029             NA         NA         NA       NA    
## ASV2834             NA         NA         NA       NA    
## ASV4003             NA         NA         NA       NA    
## ASV4064             NA         NA         NA       NA    
## ASV4294             NA         NA         NA       NA    
## ASV4609             NA         NA         NA       NA    
## ASV6283             NA         NA         NA       NA    
## ASV6491             NA         NA         NA       NA    
## ASV7453             NA         NA         NA       NA    
## ASV7959             NA         NA         NA       NA    
## ASV8219             NA         NA         NA       NA    
## ASV8547             NA         NA         NA       NA    
## ASV9319             NA         NA         NA       NA    
## ASV9382             NA         NA         NA       NA    
## ASV11516            NA         NA         NA       NA    
## ASV14377            NA         NA         NA       NA    
## ASV1867             NA         NA         NA       NA    
## ASV1895             NA         NA         NA       NA    
## ASV3168             NA         NA         NA       NA    
## ASV4449             NA         NA         NA       NA    
## ASV6596             NA         NA         NA       NA    
## ASV7492             NA         NA         NA       NA    
## ASV9854             NA         NA         NA       NA    
## ASV6296             NA         NA         NA       NA    
## ASV4201             NA         NA         NA       NA    
## ASV0552             NA         NA         NA       NA    
## ASV3671             NA         NA         NA       NA    
## ASV3529             NA         NA         NA       NA    
## ASV1060             NA         NA         NA       NA    
## ASV0239             NA         NA         NA       NA    
## ASV5711             NA         NA         NA       NA    
## ASV4152             NA         NA         NA       NA    
## ASV1461             NA         NA         NA       NA    
## ASV2877             NA         NA         NA       NA    
## ASV0012             NA         NA         NA       NA    
## ASV9823             NA         NA         NA       NA    
## ASV0008             NA         NA         NA       NA    
## ASV7832             NA         NA         NA       NA    
## ASV1915             NA         NA         NA       NA    
## ASV0055             NA         NA         NA       NA    
## ASV0032             NA         NA         NA       NA    
## ASV2977             NA         NA         NA       NA    
## ASV0466             NA         NA         NA       NA    
## ASV3866             NA         NA         NA       NA    
## ASV0040             NA         NA         NA       NA    
## ASV0496             NA         NA         NA       NA    
## ASV0052             NA         NA         NA       NA    
## ASV3828             NA         NA         NA       NA    
## ASV1930             NA         NA         NA       NA    
## ASV2126             NA         NA         NA       NA    
## ASV0793             NA         NA         NA       NA    
## ASV0299             NA         NA         NA       NA    
## ASV0208             NA         NA         NA       NA    
## ASV0511             NA         NA         NA       NA    
## ASV1123             NA         NA         NA       NA    
## ASV0099             NA         NA         NA       NA    
## ASV0752             NA         NA         NA       NA    
## ASV0883             NA         NA         NA       NA    
## ASV0683             NA         NA         NA       NA    
## ASV4117             NA         NA         NA       NA    
## ASV2172             NA         NA         NA       NA    
## ASV0330             NA         NA         NA       NA    
## ASV0728             NA         NA         NA       NA    
## ASV0499             NA         NA         NA       NA    
## ASV0120             NA         NA         NA       NA    
## ASV1446             NA         NA         NA       NA    
## ASV17171            NA         NA         NA       NA    
## ASV0533             NA         NA         NA       NA    
## ASV2495             NA         NA         NA       NA    
## ASV5582             NA         NA         NA       NA    
## ASV1488             NA         NA         NA       NA    
## ASV0682             NA         NA         NA       NA    
## ASV0068             NA         NA         NA       NA    
## ASV1987             NA         NA         NA       NA    
## ASV0035             NA         NA         NA       NA    
## ASV7192             NA         NA         NA       NA    
## ASV0873             NA         NA         NA       NA    
## ASV4749             NA         NA         NA       NA    
## ASV2174             NA         NA         NA       NA    
## ASV1476             NA         NA         NA       NA    
## ASV0740             NA         NA         NA       NA    
## ASV0170             NA         NA         NA       NA    
## ASV2466             NA         NA         NA       NA    
## ASV1709             NA         NA         NA       NA    
## ASV6170             NA         NA         NA       NA    
## ASV3673             NA         NA         NA       NA    
## ASV1745             NA         NA         NA       NA    
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
## (Dispersion parameter for binomial family taken to be 1)
## 
##     Null deviance:  385.39  on 277  degrees of freedom
## Residual deviance: 4181.06  on  42  degrees of freedom
## AIC: 4653.1
## 
## Number of Fisher Scoring iterations: 7
  • The p-values above are all the same which is not good.

From PCA of Clade C, there were about 150 or so ASVs that contributed the most in Dimension 1

lr_clr_150 <- lr_clr_df[1:152] # sample id and Clade

logreg_150 <- stats::glm(as.factor(Clade) ~ . ,
                          data = lr_clr_150[,-1],
                          family = "binomial")

  • For these data, it is not possible to get a decent logistic regression model even when reducing the ASV columns to the minimum from PCA analysis.

  • The goal was to try and estimate or explain which ASVs might present the most impact for Clade C, but thes data from the t–SNE plot above and subsequent logistic modeling attempts do not produce a good model.

  • Please see the RandomForest.Rmd file for non-linear modeling.